首页 > 最新文献

Integrated Blood Pressure Control最新文献

英文 中文
Anthropometric Indexes for Predicting High Blood Pressure in Vietnamese Adults: A Cross-Sectional Study. 预测越南成人高血压的人体测量指标:一项横断面研究。
IF 2.2 Q2 Medicine Pub Date : 2020-12-01 eCollection Date: 2020-01-01 DOI: 10.2147/IBPC.S281996
Quan Nguyen Minh, Minh Hoang Nguyen Vo

Background: The rate of hypertension and obesity is increasing in Vietnamese society. This study aimed to focus on assessing the relationship between anthropometric indexes (body mass index (BMI), waist-to-height ratio (WHtR), waist-to-hip ratio (WHR)) and high blood pressure to determine which is the best predictor for high blood pressure among adults over 18 years in Vietnam.

Methods: A cross-sectional study of 1636 people was conducted. People who were over 18 years old, healthy or had hyperlipidemia and on the treatment were recruited. Patients with cancer, heart disease, diabetes, kidney disease, and hypertension were excluded. Information on demographics, smoking and drinking habits, weight, height, waist circumference, and blood pressure was collected. Areas under receiver operating characteristic curves (AUCs) were examined to determine the predictability of anthropometric indicators for high blood pressure in men and women. Logistic regression analysis, stratified by gender, was performed to examine the association between anthropometric indexes and high blood pressure.

Results: In this study, the percentage of people with high blood pressure was 10.51%. The AUC for the WHtR was significantly greater than for the BMI for both genders. Logistic regression demonstrated that only WHtR had a significant positive association with high blood pressure among women. The optimal WHtR cut-off value for predicting high blood pressure in men and women were 0.47 and 0.50, respectively.

Conclusion: Among the indicators analyzed in this study, WHtR was the best for the predicting of the presence of high blood pressure, in both men and women. However, WHtR could only explain the changes of high blood pressure in women.

背景:越南社会高血压和肥胖率呈上升趋势。本研究旨在重点评估人体测量指数(身体质量指数(BMI)、腰高比(WHtR)、腰臀比(WHR))与高血压之间的关系,以确定哪一个是越南18岁以上成年人高血压的最佳预测指标。方法:对1636人进行横断面研究。研究人员招募了年龄在18岁以上、健康或患有高脂血症并正在接受治疗的人。排除了癌症、心脏病、糖尿病、肾病和高血压患者。收集了人口统计、吸烟和饮酒习惯、体重、身高、腰围和血压等信息。检查受试者工作特征曲线(auc)下的区域,以确定男性和女性高血压人体测量指标的可预测性。采用Logistic回归分析,按性别分层,检验人体测量指标与高血压之间的关系。结果:本研究中高血压患者的比例为10.51%。无论男女,WHtR的AUC都明显大于BMI。Logistic回归显示,女性中只有WHtR与高血压有显著正相关。预测男性和女性高血压的最佳WHtR临界值分别为0.47和0.50。结论:在本研究分析的指标中,WHtR在男性和女性中都是预测高血压存在的最佳指标。然而,WHtR只能解释女性高血压的变化。
{"title":"Anthropometric Indexes for Predicting High Blood Pressure in Vietnamese Adults: A Cross-Sectional Study.","authors":"Quan Nguyen Minh,&nbsp;Minh Hoang Nguyen Vo","doi":"10.2147/IBPC.S281996","DOIUrl":"https://doi.org/10.2147/IBPC.S281996","url":null,"abstract":"<p><strong>Background: </strong>The rate of hypertension and obesity is increasing in Vietnamese society. This study aimed to focus on assessing the relationship between anthropometric indexes (body mass index (BMI), waist-to-height ratio (WHtR), waist-to-hip ratio (WHR)) and high blood pressure to determine which is the best predictor for high blood pressure among adults over 18 years in Vietnam.</p><p><strong>Methods: </strong>A cross-sectional study of 1636 people was conducted. People who were over 18 years old, healthy or had hyperlipidemia and on the treatment were recruited. Patients with cancer, heart disease, diabetes, kidney disease, and hypertension were excluded. Information on demographics, smoking and drinking habits, weight, height, waist circumference, and blood pressure was collected. Areas under receiver operating characteristic curves (AUCs) were examined to determine the predictability of anthropometric indicators for high blood pressure in men and women. Logistic regression analysis, stratified by gender, was performed to examine the association between anthropometric indexes and high blood pressure.</p><p><strong>Results: </strong>In this study, the percentage of people with high blood pressure was 10.51%. The AUC for the WHtR was significantly greater than for the BMI for both genders. Logistic regression demonstrated that only WHtR had a significant positive association with high blood pressure among women. The optimal WHtR cut-off value for predicting high blood pressure in men and women were 0.47 and 0.50, respectively.</p><p><strong>Conclusion: </strong>Among the indicators analyzed in this study, WHtR was the best for the predicting of the presence of high blood pressure, in both men and women. However, WHtR could only explain the changes of high blood pressure in women.</p>","PeriodicalId":45299,"journal":{"name":"Integrated Blood Pressure Control","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e8/2e/ibpc-13-181.PMC7718968.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38688461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Prevalence of Hypertension and Its Associated Factors Among Gimbi Town Residents, Ethiopia: A Community-Based Cross-Sectional Study. 埃塞俄比亚金比镇居民的高血压患病率及其相关因素:一项基于社区的横断面研究。
IF 1.5 Q3 PERIPHERAL VASCULAR DISEASE Pub Date : 2020-11-26 eCollection Date: 2020-01-01 DOI: 10.2147/IBPC.S277582
Birhanu Yadecha, Firew Tekle, Getahun Fetensa, Ashenafi Habte, Bisrat Zeleke

Background: Globally, sixty-two percent of cerebrovascular disease and forty-nine percent of ischemic heart disease are attributable to increased blood pressure. Half of the patients with stroke and heart disease were due to hypertension.

Objective: This study aimed to identify prevalence of hypertension and its associated factors in Gimbi town, Ethiopia.

Methods: We conducted a community-based cross-sectional study from May to June 2017 on 471 participants in Gimbi town, western Ethiopia. A systematic sampling method was used to recruit study participants. Data collectors used structured questionnaires to gather data through face to face interview. The standardized procedure followed to measure blood pressure and anthropometric measurements by trained extension health workers. We entered data into Epi-data and exported to SPSS version 20.00 for analysis. Variables having a P-value less than or equal to 0.05 were declared as statistically significant in multivariable analysis.

Results: Four hundred seventy-one participants were included with a response rate of 98.85%, and 248 (52.6%) were female. The prevalence of isolated systolic and diastolic hypertension was 9.55% and 9.3%, respectively. Of 157 (33.5%) hypertensive participants, 117 (24.8%) were newly diagnosed. Age 35-55 [AOR: 2.335 95% CI (1.360-4.009)], ≥55 [(AOR: 3.566 95% CI (1.288-9.876))], occupation, government employee [(AOR: 3.072 95% CI (1.458-6.474))], merchants [(AOR: 3.177 95% CI (1.290-7.824))], ever alcohol drinker [(AOR: 2.333 95% CI (1.320-4.122))], and family history of hypertension [(AOR: 6.642 95% CI (4.068-10.843))] were found to be predictor variables for hypertension.

Conclusion: The findings of this study indicated a hidden high prevalence of hypertension indicating the need for stakeholders' collaboration to design and implement a mobile blood pressure screening programs at the community level.

背景:全球有 62% 的脑血管疾病和 49% 的缺血性心脏病可归因于血压升高。在中风和心脏病患者中,有一半是由高血压引起的:本研究旨在确定埃塞俄比亚金比镇的高血压患病率及其相关因素:我们于 2017 年 5 月至 6 月在埃塞俄比亚西部金比镇对 471 名参与者进行了一项基于社区的横断面研究。研究采用系统抽样法招募参与者。数据收集人员使用结构化问卷,通过面对面访谈收集数据。经过培训的推广卫生工作者按照标准化程序测量血压和人体测量数据。我们将数据输入 Epi-data,并导出到 SPSS 20.00 版进行分析。在多变量分析中,P 值小于或等于 0.05 的变量被视为具有统计学意义:共纳入 471 名参与者,回复率为 98.85%,其中 248 人(52.6%)为女性。孤立的收缩期和舒张期高血压患病率分别为 9.55% 和 9.3%。在 157 名(33.5%)高血压患者中,有 117 名(24.8%)是新确诊的。年龄 35-55 [AOR: 2.335 95% CI (1.360-4.009)]、≥55 [(AOR: 3.566 95% CI (1.288-9.876))]、职业、政府雇员[(AOR: 3.072 95% CI (1.458-6.474))]、商人[(AOR: 3.177 95% CI (1.290-7.824))]、曾经酗酒[(AOR: 2.335 95% CI (1.360-4.009))]。824))]、曾经饮酒[(AOR:2.333 95% CI(1.320-4.122))]和高血压家族史[(AOR:6.642 95% CI(4.068-10.843))]被认为是高血压的预测变量:本研究的结果表明,高血压的发病率较高,这表明需要利益相关者合作,在社区层面设计和实施流动血压筛查计划。
{"title":"Prevalence of Hypertension and Its Associated Factors Among Gimbi Town Residents, Ethiopia: A Community-Based Cross-Sectional Study.","authors":"Birhanu Yadecha, Firew Tekle, Getahun Fetensa, Ashenafi Habte, Bisrat Zeleke","doi":"10.2147/IBPC.S277582","DOIUrl":"10.2147/IBPC.S277582","url":null,"abstract":"<p><strong>Background: </strong>Globally, sixty-two percent of cerebrovascular disease and forty-nine percent of ischemic heart disease are attributable to increased blood pressure. Half of the patients with stroke and heart disease were due to hypertension.</p><p><strong>Objective: </strong>This study aimed to identify prevalence of hypertension and its associated factors in Gimbi town, Ethiopia.</p><p><strong>Methods: </strong>We conducted a community-based cross-sectional study from May to June 2017 on 471 participants in Gimbi town, western Ethiopia. A systematic sampling method was used to recruit study participants. Data collectors used structured questionnaires to gather data through face to face interview. The standardized procedure followed to measure blood pressure and anthropometric measurements by trained extension health workers. We entered data into Epi-data and exported to SPSS version 20.00 for analysis. Variables having a P-value less than or equal to 0.05 were declared as statistically significant in multivariable analysis.</p><p><strong>Results: </strong>Four hundred seventy-one participants were included with a response rate of 98.85%, and 248 (52.6%) were female. The prevalence of isolated systolic and diastolic hypertension was 9.55% and 9.3%, respectively. Of 157 (33.5%) hypertensive participants, 117 (24.8%) were newly diagnosed. Age 35-55 [AOR: 2.335 95% CI (1.360-4.009)], ≥55 [(AOR: 3.566 95% CI (1.288-9.876))], occupation, government employee [(AOR: 3.072 95% CI (1.458-6.474))], merchants [(AOR: 3.177 95% CI (1.290-7.824))], ever alcohol drinker [(AOR: 2.333 95% CI (1.320-4.122))], and family history of hypertension [(AOR: 6.642 95% CI (4.068-10.843))] were found to be predictor variables for hypertension.</p><p><strong>Conclusion: </strong>The findings of this study indicated a hidden high prevalence of hypertension indicating the need for stakeholders' collaboration to design and implement a mobile blood pressure screening programs at the community level.</p>","PeriodicalId":45299,"journal":{"name":"Integrated Blood Pressure Control","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2020-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/83/87/ibpc-13-171.PMC7705951.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38673167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Matrix Metalloproteinases and Hypertension-Mediated Organ Damage: Current Insights. 基质金属蛋白酶和高血压介导的器官损伤:当前的见解。
IF 2.2 Q2 Medicine Pub Date : 2020-11-02 eCollection Date: 2020-01-01 DOI: 10.2147/IBPC.S223341
Valeria Bisogni, Alberto Cerasari, Giacomo Pucci, Gaetano Vaudo

Matrix metalloproteinases (MMPs) are important extracellular enzymes involved in many physiological and pathological processes. Changes in the activity and concentration of specific MMPs, as well as the unbalance with their inhibitors (tissue inhibitors of metalloproteinases - TIMPs), have been described as a part of the pathogenic cascade promoted by arterial hypertension. MMPs are able to degrade various protein substrates in the extracellular matrix, to influence endothelial cells function, vascular smooth muscle cells migration, proliferation and contraction, and to stimulate cardiomyocytes changes. All these processes can be activated by chronically elevated blood pressure values. Animal and human studies demonstrated the key function of MMPs in the pathogenesis of hypertension-mediated vascular, cardiac, and renal damage, besides age and blood pressure values. Thus, the role of MMPs as biomarkers of hypertension-mediated organ damage and potential pharmacological treatment targets to prevent further cardiovascular and renal complications in hypertensive population is increasingly supported. In this review, we aimed to describe the main scientific evidence about the behavior of MMPs in the development of vascular, cardiac, and renal damage in hypertensive patients.

基质金属蛋白酶(MMPs)是一种重要的细胞外酶,参与许多生理和病理过程。特异性MMPs活性和浓度的变化,以及与它们的抑制剂(组织金属蛋白酶抑制剂- TIMPs)的不平衡,已被描述为由动脉高血压促进的致病性级联反应的一部分。MMPs能够降解细胞外基质中的各种蛋白底物,影响内皮细胞功能,血管平滑肌细胞的迁移、增殖和收缩,刺激心肌细胞的变化。所有这些过程都可以被长期升高的血压值激活。动物和人体研究表明,除了年龄和血压值外,MMPs在高血压介导的血管、心脏和肾脏损害的发病机制中也起着关键作用。因此,MMPs作为高血压介导的器官损伤的生物标志物和潜在的药物治疗靶点在高血压人群中预防进一步的心血管和肾脏并发症的作用越来越得到支持。在这篇综述中,我们旨在描述MMPs在高血压患者血管、心脏和肾脏损害发展中的主要科学证据。
{"title":"Matrix Metalloproteinases and Hypertension-Mediated Organ Damage: Current Insights.","authors":"Valeria Bisogni,&nbsp;Alberto Cerasari,&nbsp;Giacomo Pucci,&nbsp;Gaetano Vaudo","doi":"10.2147/IBPC.S223341","DOIUrl":"https://doi.org/10.2147/IBPC.S223341","url":null,"abstract":"<p><p>Matrix metalloproteinases (MMPs) are important extracellular enzymes involved in many physiological and pathological processes. Changes in the activity and concentration of specific MMPs, as well as the unbalance with their inhibitors (tissue inhibitors of metalloproteinases - TIMPs), have been described as a part of the pathogenic cascade promoted by arterial hypertension. MMPs are able to degrade various protein substrates in the extracellular matrix, to influence endothelial cells function, vascular smooth muscle cells migration, proliferation and contraction, and to stimulate cardiomyocytes changes. All these processes can be activated by chronically elevated blood pressure values. Animal and human studies demonstrated the key function of MMPs in the pathogenesis of hypertension-mediated vascular, cardiac, and renal damage, besides age and blood pressure values. Thus, the role of MMPs as biomarkers of hypertension-mediated organ damage and potential pharmacological treatment targets to prevent further cardiovascular and renal complications in hypertensive population is increasingly supported. In this review, we aimed to describe the main scientific evidence about the behavior of MMPs in the development of vascular, cardiac, and renal damage in hypertensive patients.</p>","PeriodicalId":45299,"journal":{"name":"Integrated Blood Pressure Control","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2020-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/IBPC.S223341","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38590921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Adherence to Lifestyle Modifications and Associated Factors Among Adult Hypertensive Patients Attending Chronic Follow-Up Units of Dessie Referral Hospital, North East Ethiopia, 2020. 埃塞俄比亚东北部Dessie转诊医院慢性随访单元成年高血压患者生活方式改变依从性及相关因素
IF 2.2 Q2 Medicine Pub Date : 2020-10-23 eCollection Date: 2020-01-01 DOI: 10.2147/IBPC.S275575
Atsedemariam Andualem, Habtam Gelaye, Yitayish Damtie

Background: Hypertension is a major health problem throughout the world which affects over one billion people due to severe complications and inadequate control. Even though lifestyle modification is one of the most effective ways to prevent and control hypertension, only little emphasis has been given for it compared with treating hypertension with medication. Therefore, the aim of this study was to assess adherence to lifestyle modifications and associated factors among hypertensive patients attending Dessie referral hospital.

Materials and methods: Institutional-based cross-sectional study design was conducted among 301 hypertensive patients during May and June, 2020. The study participants were selected with a convenient sampling technique due to the COVID-19 pandemic. Data were collected using pre-tested and structured face to face interviewer-administered questionnaire and checked, cleaned and entered into Epi data version 4.4 and exported to SPSS version 25.0 software for analysis. The associations between independent variables and dependent variable were analyzed using binary logistic regression models.

Results: A total of 301 respondents participated in the study yielding a response of 100%. The overall adherence in this study was only 23.6%. Independent predictors of adherence to lifestyle modifications were divorced (AOR=0.35; 95% CI (0.13-0.94)) and widowed (AOR=0.27; 95% CI (0.10-0.75)), secondary school education (AOR=4.85; 95% CI (1.54-15.22)), no regular income (AOR=0.22; 95% CI (0.08-0.65)) or monthly income of ≥3000 ETB (AOR=5.58; 95% CI (2.46-12.66)), having co-morbidities (AOR=2.37; CI (1.23-4.57)), good knowledge about the disease (AOR=1.83; CI (0.92-3.65)) and good self-efficacy (AOR=3.64; CI (1.75-7.55)).

Conclusion and recommendations: The overall adherence to recommended lifestyle modifications was very low. The independent predictors were marital status, educational level, monthly income, having co-morbidities, knowledge and self-efficacy. Therefore, multifaceted and collaborative implementation of strategies about lifestyle modifications for hypertension prevention and control are needed to address barriers at the patient, provider, system and community levels.

背景:高血压是世界范围内的一个主要健康问题,由于严重并发症和控制不足,影响了超过10亿人。尽管改变生活方式是预防和控制高血压最有效的方法之一,但与药物治疗高血压相比,人们对它的重视程度却很少。因此,本研究的目的是评估在Dessie转诊医院就诊的高血压患者对生活方式改变的依从性及其相关因素。材料与方法:采用基于机构的横断面研究设计,于2020年5 - 6月对301例高血压患者进行研究。由于COVID-19大流行,采用方便的抽样技术选择了研究参与者。数据采用预测、结构化的面对面访谈问卷收集,经检查、清理后录入Epi数据4.4版,导出至SPSS 25.0版软件进行分析。采用二元logistic回归模型分析自变量与因变量之间的关系。结果:共有301名受访者参与了这项研究,并获得了100%的回应。本研究的总体依从性仅为23.6%。生活方式改变依从性的独立预测因子为离婚(AOR=0.35;95% CI(0.13-0.94))和丧偶(AOR=0.27;95% CI(0.10-0.75))、中学教育程度(AOR=4.85;95% CI(1.54-15.22)),无固定收入(AOR=0.22;95% CI(0.08-0.65))或月收入≥3000 ETB (AOR=5.58;95% CI(2.46-12.66)),有合并症(AOR=2.37;CI(1.23-4.57)),对疾病有良好的了解(AOR=1.83;CI(0.92-3.65))和良好的自我效能(AOR=3.64;CI(1.75 - -7.55))。结论和建议:对所建议的生活方式改变的总体依从性非常低。独立预测因子为婚姻状况、受教育程度、月收入、是否有合并症、知识和自我效能感。因此,需要多方协作实施改变生活方式以预防和控制高血压的策略,以解决患者、提供者、系统和社区层面的障碍。
{"title":"Adherence to Lifestyle Modifications and Associated Factors Among Adult Hypertensive Patients Attending Chronic Follow-Up Units of Dessie Referral Hospital, North East Ethiopia, 2020.","authors":"Atsedemariam Andualem,&nbsp;Habtam Gelaye,&nbsp;Yitayish Damtie","doi":"10.2147/IBPC.S275575","DOIUrl":"https://doi.org/10.2147/IBPC.S275575","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is a major health problem throughout the world which affects over one billion people due to severe complications and inadequate control. Even though lifestyle modification is one of the most effective ways to prevent and control hypertension, only little emphasis has been given for it compared with treating hypertension with medication. Therefore, the aim of this study was to assess adherence to lifestyle modifications and associated factors among hypertensive patients attending Dessie referral hospital.</p><p><strong>Materials and methods: </strong>Institutional-based cross-sectional study design was conducted among 301 hypertensive patients during May and June, 2020. The study participants were selected with a convenient sampling technique due to the COVID-19 pandemic. Data were collected using pre-tested and structured face to face interviewer-administered questionnaire and checked, cleaned and entered into Epi data version 4.4 and exported to SPSS version 25.0 software for analysis. The associations between independent variables and dependent variable were analyzed using binary logistic regression models.</p><p><strong>Results: </strong>A total of 301 respondents participated in the study yielding a response of 100%. The overall adherence in this study was only 23.6%. Independent predictors of adherence to lifestyle modifications were divorced (AOR=0.35; 95% CI (0.13-0.94)) and widowed (AOR=0.27; 95% CI (0.10-0.75)), secondary school education (AOR=4.85; 95% CI (1.54-15.22)), no regular income (AOR=0.22; 95% CI (0.08-0.65)) or monthly income of ≥3000 ETB (AOR=5.58; 95% CI (2.46-12.66)), having co-morbidities (AOR=2.37; CI (1.23-4.57)), good knowledge about the disease (AOR=1.83; CI (0.92-3.65)) and good self-efficacy (AOR=3.64; CI (1.75-7.55)).</p><p><strong>Conclusion and recommendations: </strong>The overall adherence to recommended lifestyle modifications was very low. The independent predictors were marital status, educational level, monthly income, having co-morbidities, knowledge and self-efficacy. Therefore, multifaceted and collaborative implementation of strategies about lifestyle modifications for hypertension prevention and control are needed to address barriers at the patient, provider, system and community levels.</p>","PeriodicalId":45299,"journal":{"name":"Integrated Blood Pressure Control","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2020-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/IBPC.S275575","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38544178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Epidemiology of Hypertension in Ethiopia: A Systematic Review. 埃塞俄比亚高血压流行病学:一项系统综述。
IF 2.2 Q2 Medicine Pub Date : 2020-10-15 eCollection Date: 2020-01-01 DOI: 10.2147/IBPC.S276089
Nanati Legese, Yohannes Tadiwos

Background: Hypertension is one of the leading causes of disease in the world. This study is a systematic review paper, intended to provide compressive evidence on the prevalence, distribution, determinants, and burden of hypertension in Ethiopia.

Methods: A quantitative epidemiological literature review was conducted by searching different articles in different databases, including PubMed, Cochrane, and Google scholar. The search involved population-based, hospital-based, and institution-based studies on hypertension conducted in Ethiopia. All data were extracted independently by two reviewers using data collection formats. Finally, this review included 22 studies.

Results: Different studies reported varied prevalence of hypertension because of the differences in participant's mean ages, source population, and study settings. Population-based studies revealed the prevalence of hypertension to be 9.3-30.3%, institution-based studies revealed 7-37%, whereas hospital-based studies revealed 13.2-18.8%. In studies included in this review, about 37-78% of hypertensive patients were not aware of their blood pressure condition. There was a high prevalence of hypertension in urban residents, and different factors were associated with hypertension, including being overweight, family history of hypertension, age, sex, diabetes mellitus, alcohol intake, physical inactivity, and obesity.

Conclusion and recommendation: Hypertension was substantially prevalent in Ethiopia, which calls for the implementation of timely and appropriate strategies for the prevention and control of the disease.

背景:高血压是世界上最主要的疾病之一。本研究是一篇系统综述论文,旨在提供关于埃塞俄比亚高血压患病率、分布、决定因素和负担的有力证据。方法:通过检索PubMed、Cochrane、Google scholar等不同数据库的不同文章,进行定量流行病学文献综述。检索包括在埃塞俄比亚进行的基于人群、基于医院和基于机构的高血压研究。所有数据均由两位审稿人使用数据收集格式独立提取。最后,本综述纳入了22项研究。结果:由于参与者的平均年龄、源人群和研究环境的差异,不同的研究报告了不同的高血压患病率。基于人群的研究显示高血压患病率为9.3-30.3%,基于机构的研究显示为7-37%,而基于医院的研究显示为13.2-18.8%。在本综述纳入的研究中,约37-78%的高血压患者没有意识到自己的血压状况。城市居民高血压患病率较高,与高血压相关的因素有:超重、高血压家族史、年龄、性别、糖尿病、饮酒、缺乏运动、肥胖等。结论和建议:高血压在埃塞俄比亚相当普遍,因此需要及时实施适当的战略,预防和控制这一疾病。
{"title":"Epidemiology of Hypertension in Ethiopia: A Systematic Review.","authors":"Nanati Legese,&nbsp;Yohannes Tadiwos","doi":"10.2147/IBPC.S276089","DOIUrl":"https://doi.org/10.2147/IBPC.S276089","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is one of the leading causes of disease in the world. This study is a systematic review paper, intended to provide compressive evidence on the prevalence, distribution, determinants, and burden of hypertension in Ethiopia.</p><p><strong>Methods: </strong>A quantitative epidemiological literature review was conducted by searching different articles in different databases, including PubMed, Cochrane, and Google scholar. The search involved population-based, hospital-based, and institution-based studies on hypertension conducted in Ethiopia. All data were extracted independently by two reviewers using data collection formats. Finally, this review included 22 studies.</p><p><strong>Results: </strong>Different studies reported varied prevalence of hypertension because of the differences in participant's mean ages, source population, and study settings. Population-based studies revealed the prevalence of hypertension to be 9.3-30.3%, institution-based studies revealed 7-37%, whereas hospital-based studies revealed 13.2-18.8%. In studies included in this review, about 37-78% of hypertensive patients were not aware of their blood pressure condition. There was a high prevalence of hypertension in urban residents, and different factors were associated with hypertension, including being overweight, family history of hypertension, age, sex, diabetes mellitus, alcohol intake, physical inactivity, and obesity.</p><p><strong>Conclusion and recommendation: </strong>Hypertension was substantially prevalent in Ethiopia, which calls for the implementation of timely and appropriate strategies for the prevention and control of the disease.</p>","PeriodicalId":45299,"journal":{"name":"Integrated Blood Pressure Control","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2020-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/IBPC.S276089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38546032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Aortic Stiffness and Diastolic Dysfunction in Sprague Dawley Rats Consuming Short-Term Fructose Plus High Salt Diet. 短期果糖加高盐饮食对大鼠主动脉僵硬和舒张功能障碍的影响。
IF 2.2 Q2 Medicine Pub Date : 2020-09-28 eCollection Date: 2020-01-01 DOI: 10.2147/IBPC.S257205
Dragana Komnenov, Peter E Levanovich, Natalia Perecki, Charles S Chung, Noreen F Rossi

Introduction: High fructose and salt consumption continues to be prevalent in western society. Existing studies show that a rat model reflecting a diet of fructose and salt consumed by the upper 20th percentile of the human population results in salt-sensitive hypertension mitigated by treatment with an antioxidant. We hypothesized that dietary fructose, rather than glucose, combined with high salt leads to aortic stiffening and decreased renal artery compliance. We also expect that daily supplementation with the antioxidant, 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (+T; Tempol), will ameliorate the increase in mean arterial pressure (MAP) and vascular changes.

Methods: Male Sprague Dawley rats were studied with either 20% fructose or 20% glucose in the drinking water and normal salt (0.4%) or high salt (4%) in the chow resulting in four dietary groups: fructose normal Fru+NS or high salt (Fru+HS) or glucose with normal (Glu+NS) or high salt (Glu+HS). Tempol (+T) was added to the drinking water in half of the rats in each group for 3 weeks.

Results: MAP was significantly elevated and the glucose:insulin ratio was depressed in the Fru+HS. Both parameters were normalized in Fru+HS+T. Plasma renin activity (PRA) and kidney tissue angiotensin II (Ang II) were not suppressed in the high salt groups. Pulse wave velocity (PWV), radial ascending strain, and distensibility coefficient of the ascending aorta were significantly decreased in Fru+HS rats and improved in the Fru+HS+T rats. No differences occurred in left ventricular systolic function, but the ratio of early (E) to late (A) transmitral filling velocities was decreased and renal resistive index (RRI) was higher in Fru+HS rats; antioxidant treatment did not change these indices.

Discussion: Thus, short-term consumption of high fructose plus high salt diet by rats results in modest hypertension, insulin resistance, diminished aortic and renal artery compliance, and left ventricular diastolic dysfunction. Antioxidant treatment ameliorates the blood pressure, insulin resistance and aortic stiffness, but not renal artery stiffness and left ventricular diastolic dysfunction.

引言:高果糖和高盐的摄入在西方社会仍然很普遍。现有的研究表明,一个大鼠模型反映了20百分位以上的人群摄入果糖和盐的饮食导致盐敏感性高血压,用抗氧化剂治疗可以减轻这种高血压。我们假设饮食中的果糖,而不是葡萄糖,结合高盐导致主动脉硬化和肾动脉顺应性降低。我们还期望每天补充抗氧化剂,4-羟基-2,2,6,6-四甲基哌啶-1-氧(+T;Tempol),将改善平均动脉压(MAP)升高和血管变化。方法:雄性斯普拉格·道利大鼠分别在饮水中添加20%果糖或20%葡萄糖,并在饲料中添加正常盐(0.4%)或高盐(4%),将其分为四组:果糖正常Fru+NS或高盐(Fru+HS)或葡萄糖正常(Glu+NS)或高盐(Glu+HS)。每组半数大鼠在饮水中加入天宝(+T),连续3周。结果:Fru+HS组MAP明显升高,葡萄糖胰岛素比明显降低。两个参数均归一化为Fru+HS+T。高盐组血浆肾素活性(PRA)和肾组织血管紧张素II (Ang II)未受抑制。Fru+HS大鼠的脉波速度(PWV)、径向上升应变、升主动脉扩张系数显著降低,Fru+HS+T大鼠的升主动脉扩张系数显著提高。Fru+HS大鼠左室收缩功能无差异,但早期(E)与晚期(A)递质充盈速度之比降低,肾阻力指数(RRI)升高;抗氧化处理对上述指标无明显影响。讨论:因此,大鼠短期食用高果糖加高盐饮食会导致中度高血压、胰岛素抵抗、主动脉和肾动脉顺应性降低以及左室舒张功能障碍。抗氧化治疗可改善血压、胰岛素抵抗和主动脉僵硬,但不能改善肾动脉僵硬和左心室舒张功能障碍。
{"title":"Aortic Stiffness and Diastolic Dysfunction in Sprague Dawley Rats Consuming Short-Term Fructose Plus High Salt Diet.","authors":"Dragana Komnenov,&nbsp;Peter E Levanovich,&nbsp;Natalia Perecki,&nbsp;Charles S Chung,&nbsp;Noreen F Rossi","doi":"10.2147/IBPC.S257205","DOIUrl":"https://doi.org/10.2147/IBPC.S257205","url":null,"abstract":"<p><strong>Introduction: </strong>High fructose and salt consumption continues to be prevalent in western society. Existing studies show that a rat model reflecting a diet of fructose and salt consumed by the upper 20th percentile of the human population results in salt-sensitive hypertension mitigated by treatment with an antioxidant. We hypothesized that dietary fructose, rather than glucose, combined with high salt leads to aortic stiffening and decreased renal artery compliance. We also expect that daily supplementation with the antioxidant, 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (+T; Tempol), will ameliorate the increase in mean arterial pressure (MAP) and vascular changes.</p><p><strong>Methods: </strong>Male Sprague Dawley rats were studied with either 20% fructose or 20% glucose in the drinking water and normal salt (0.4%) or high salt (4%) in the chow resulting in four dietary groups: fructose normal Fru+NS or high salt (Fru+HS) or glucose with normal (Glu+NS) or high salt (Glu+HS). Tempol (+T) was added to the drinking water in half of the rats in each group for 3 weeks.</p><p><strong>Results: </strong>MAP was significantly elevated and the glucose:insulin ratio was depressed in the Fru+HS. Both parameters were normalized in Fru+HS+T. Plasma renin activity (PRA) and kidney tissue angiotensin II (Ang II) were not suppressed in the high salt groups. Pulse wave velocity (PWV), radial ascending strain, and distensibility coefficient of the ascending aorta were significantly decreased in Fru+HS rats and improved in the Fru+HS+T rats. No differences occurred in left ventricular systolic function, but the ratio of early (E) to late (A) transmitral filling velocities was decreased and renal resistive index (RRI) was higher in Fru+HS rats; antioxidant treatment did not change these indices.</p><p><strong>Discussion: </strong>Thus, short-term consumption of high fructose plus high salt diet by rats results in modest hypertension, insulin resistance, diminished aortic and renal artery compliance, and left ventricular diastolic dysfunction. Antioxidant treatment ameliorates the blood pressure, insulin resistance and aortic stiffness, but not renal artery stiffness and left ventricular diastolic dysfunction.</p>","PeriodicalId":45299,"journal":{"name":"Integrated Blood Pressure Control","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/IBPC.S257205","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38595557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Approaches to the Management of Hypertension in Resource-Limited Settings: Strategies to Overcome the Hypertension Crisis in the Post-COVID Era. 资源有限环境下高血压管理的途径:克服后covid时代高血压危机的策略
IF 2.2 Q2 Medicine Pub Date : 2020-09-28 eCollection Date: 2020-01-01 DOI: 10.2147/IBPC.S261031
Jamario Skeete, Kenneth Connell, Pedro Ordunez, Donald J DiPette

The COVID-19 pandemic has changed most aspects of everyday life in both the non-medical and medical settings. In the medical world, the pandemic has altered how healthcare is delivered and has necessitated an aggressive and new coordinated public health approach to limit its spread and reduce its disease burden and socioeconomic impact. This pandemic has resulted in a staggering morbidity and mortality and massive economic and physical hardships. Meanwhile, non-communicable diseases such as hypertension, diabetes mellitus, and cardiovascular disease in general continue to cause significant disease burden globally in the background. Though presently receiving less attention in the public eye than the COVID-19 pandemic, the hypertension crisis cannot be separated from the minds of healthcare providers, policymakers and the general public, as it continues to wreak havoc, particularly in vulnerable populations in resource limited settings. On this background, many of the strategies being employed to combat the COVID-19 pandemic can be used to re-energize and galvanize the fight against hypertension and hopefully bring the public health crisis associated with uncontrolled hypertension to an end.

2019冠状病毒病大流行改变了非医疗和医疗环境中日常生活的大多数方面。在医学界,大流行改变了提供医疗保健的方式,需要采取积极和协调一致的新公共卫生办法,以限制其传播,减少疾病负担和社会经济影响。这一流行病造成了惊人的发病率和死亡率以及巨大的经济和物质困难。与此同时,高血压、糖尿病和一般心血管疾病等非传染性疾病继续在全球范围内造成重大疾病负担。尽管目前公众对高血压危机的关注程度不如COVID-19大流行,但高血压危机仍在医疗服务提供者、政策制定者和公众的脑海中挥之不去,因为它继续造成严重破坏,特别是在资源有限的环境中对弱势群体造成严重破坏。在此背景下,许多用于抗击COVID-19大流行的战略可用于重振和激励防治高血压的斗争,并有望结束与不受控制的高血压相关的公共卫生危机。
{"title":"Approaches to the Management of Hypertension in Resource-Limited Settings: Strategies to Overcome the Hypertension Crisis in the Post-COVID Era.","authors":"Jamario Skeete,&nbsp;Kenneth Connell,&nbsp;Pedro Ordunez,&nbsp;Donald J DiPette","doi":"10.2147/IBPC.S261031","DOIUrl":"https://doi.org/10.2147/IBPC.S261031","url":null,"abstract":"<p><p>The COVID-19 pandemic has changed most aspects of everyday life in both the non-medical and medical settings. In the medical world, the pandemic has altered how healthcare is delivered and has necessitated an aggressive and new coordinated public health approach to limit its spread and reduce its disease burden and socioeconomic impact. This pandemic has resulted in a staggering morbidity and mortality and massive economic and physical hardships. Meanwhile, non-communicable diseases such as hypertension, diabetes mellitus, and cardiovascular disease in general continue to cause significant disease burden globally in the background. Though presently receiving less attention in the public eye than the COVID-19 pandemic, the hypertension crisis cannot be separated from the minds of healthcare providers, policymakers and the general public, as it continues to wreak havoc, particularly in vulnerable populations in resource limited settings. On this background, many of the strategies being employed to combat the COVID-19 pandemic can be used to re-energize and galvanize the fight against hypertension and hopefully bring the public health crisis associated with uncontrolled hypertension to an end.</p>","PeriodicalId":45299,"journal":{"name":"Integrated Blood Pressure Control","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/IBPC.S261031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38595558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Admission and Inpatient Mortality of Hypertension Complications in Addis Ababa. 亚的斯亚贝巴高血压并发症的入院和住院死亡率。
IF 2.2 Q2 Medicine Pub Date : 2020-09-16 eCollection Date: 2020-01-01 DOI: 10.2147/IBPC.S268184
Abayneh Birlie Zeru, Mikyas Arega Muluneh

Background: The number of people with undiagnosed, untreated, and uncontrolled hypertension is higher in Ethiopia. This in turn increases the risk of developing complications and hospitalization. This study aimed to assess the prevalence of hypertension complication hospitalization among medical admissions and admission outcomes of hypertension complication patients in the medical ward of Saint Peter Specialized Hospital, Addis Ababa.

Methods: We used a hospital-based cross-sectional study. Data were collected by reviewing all medical ward admission logbook records from January 1st, 2018 to December 30th, 2019. An individual patient folder of 308 patients admitted due to hypertension complications was selected for further detailed investigation and then entered into Epi Data version 3.1 and exported to SPSS version 24 statistical software for analysis.

Results: Of the total 2728 medical admissions, 308 (11.3%) were patients with hypertension complications. Hypertension complications account for 308 (11.3%) of all medical admissions. Their mean age and length of hospital stay were 59.85 (± 16.36) years and 11.45 (± 11.48) days, respectively. Near to two-third of 196 (63.6%) of them were stroke patients followed by 76 (24.7%) heart disease. Fifty-two (16.9%) hypertension complication patients died at admission which accounts for 52 (14.6%) of all medical ward deaths. As age increases, the risk of death at admission increases by 6.5%. Similarly, the risk of death increased by three-fold for a month increase in the duration of anti-hypertensive drug discontinuation. Rural residents had a 3.5% lesser risk of death than urban patients.

Conclusion: Hypertension complications had a significant share of the medical ward mortality rate. Cerebrovascular and cardiovascular complications were common causes of hospitalization and inpatient death. Old age, urban residence, and prolonged duration of anti-hypertensive drug discontinuation increased the risk of death at admission.

背景:在埃塞俄比亚,未确诊、未治疗和未控制的高血压人数较高。这反过来又增加了发生并发症和住院的风险。本研究旨在评估亚的斯亚贝巴圣彼得专科医院内科病房高血压并发症住院的患病率和高血压并发症患者的入院结果。方法:我们采用以医院为基础的横断面研究。通过查阅2018年1月1日至2019年12月30日所有住院日志记录收集数据。选取308例因高血压合并症入院患者的个体患者文件夹进行进一步详细调查,输入Epi Data 3.1版,导出到SPSS 24版统计软件进行分析。结果:2728例住院患者中,合并高血压并发症308例(11.3%)。高血压并发症占所有住院病人的308例(11.3%)。患者平均年龄59.85(±16.36)岁,平均住院时间11.45(±11.48)天。196名患者中近三分之二(63.6%)是中风患者,其次是76名(24.7%)心脏病患者。入院时高血压并发症死亡52例(16.9%),占住院总死亡52例(14.6%)。随着年龄的增长,入院时的死亡风险增加6.5%。同样,停止服用降压药的时间每延长一个月,死亡风险增加三倍。农村居民的死亡风险比城市患者低3.5%。结论:高血压并发症在内科病房死亡率中占有重要的份额。脑血管和心血管并发症是住院和住院患者死亡的常见原因。老年、城市居住和抗高血压药物停药时间延长增加了入院时的死亡风险。
{"title":"Admission and Inpatient Mortality of Hypertension Complications in Addis Ababa.","authors":"Abayneh Birlie Zeru,&nbsp;Mikyas Arega Muluneh","doi":"10.2147/IBPC.S268184","DOIUrl":"https://doi.org/10.2147/IBPC.S268184","url":null,"abstract":"<p><strong>Background: </strong>The number of people with undiagnosed, untreated, and uncontrolled hypertension is higher in Ethiopia. This in turn increases the risk of developing complications and hospitalization. This study aimed to assess the prevalence of hypertension complication hospitalization among medical admissions and admission outcomes of hypertension complication patients in the medical ward of Saint Peter Specialized Hospital, Addis Ababa.</p><p><strong>Methods: </strong>We used a hospital-based cross-sectional study. Data were collected by reviewing all medical ward admission logbook records from January 1st, 2018 to December 30th, 2019. An individual patient folder of 308 patients admitted due to hypertension complications was selected for further detailed investigation and then entered into Epi Data version 3.1 and exported to SPSS version 24 statistical software for analysis.</p><p><strong>Results: </strong>Of the total 2728 medical admissions, 308 (11.3%) were patients with hypertension complications. Hypertension complications account for 308 (11.3%) of all medical admissions. Their mean age and length of hospital stay were 59.85 (± 16.36) years and 11.45 (± 11.48) days, respectively. Near to two-third of 196 (63.6%) of them were stroke patients followed by 76 (24.7%) heart disease. Fifty-two (16.9%) hypertension complication patients died at admission which accounts for 52 (14.6%) of all medical ward deaths. As age increases, the risk of death at admission increases by 6.5%. Similarly, the risk of death increased by three-fold for a month increase in the duration of anti-hypertensive drug discontinuation. Rural residents had a 3.5% lesser risk of death than urban patients.</p><p><strong>Conclusion: </strong>Hypertension complications had a significant share of the medical ward mortality rate. Cerebrovascular and cardiovascular complications were common causes of hospitalization and inpatient death. Old age, urban residence, and prolonged duration of anti-hypertensive drug discontinuation increased the risk of death at admission.</p>","PeriodicalId":45299,"journal":{"name":"Integrated Blood Pressure Control","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2020-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/IBPC.S268184","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38425707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Prevalence of Hypertensive Emergency and Associated Factors Among Hospitalized Patients with Hypertensive Crisis: A Retrospective Cross-Sectional Study. 住院高血压危象患者高血压急症患病率及相关因素:一项回顾性横断面研究
IF 2.2 Q2 Medicine Pub Date : 2020-08-18 eCollection Date: 2020-01-01 DOI: 10.2147/IBPC.S265183
Desilu Mahari Desta, Dawit Zewdu Wondafrash, Afewerki Gebremeskel Tsadik, Gebremicheal Gebreslassie Kasahun, Segen Tassew, Teklu Gebrehiwot, Solomon Weldegebreal Asgedom

Background: Hypertensive emergency (HE) is an acute stage of uncontrolled blood pressure which poses a substantial cardiovascular morbidity and mortality in developing countries. In our setting, the prevalence of HE and the characteristics of patients with a hypertensive crisis are not certainly known yet.

Objective: The study assessed the prevalence of hypertensive emergency and associated factors among hospitalized patients with hypertensive crisis.

Methods: A retrospective cross-sectional study was conducted by reviewing records of patients having a diagnosis of hypertensive crisis with systolic/diastolic blood pressure raised to more than 180/120 mmHg admitted to Ayder Comprehensive Specialized Hospital (ACSH) from September 2018 to August 2019. Patients' medical records with complete information were enrolled consecutively. Socio-demographic, clinical characteristics, and other related variables were collected using a structured data collection tool from patient medical records. Data were entered and analyzed using SPSS version 20. Logistic regression was employed to determine factors associated with HE.

Results: A total of 141 patients' records with a diagnosis of a hypertensive crisis were enrolled in the study; the majority were females 77 (54.6%) and residing in the urban setting 104 (73.8%). The mean age of the participants was 58.8 years. HE was found in 42 (29.8%) of patients. Intravenous Hydralazine 39 (27.7%) and oral calcium channel blocker 102 (72.3%) were the prescribed drugs for acute blood pressure reduction in the emergency setting. Surprisingly, patients who had no history of hypertension (adjusted odds ratio (AOR)=2.469; 95% confidence interval (CI): 0.176‒0.933) and female sex (AOR=2.494; 95% CI: 1.111‒5.596) were found to be independently associated factors with HE.

Conclusion: The prevalence of HE was found to account a significant proportion of patients. Hence, hypertensive patients should be strictly managed accordingly, and promoting screening programs could reduce the risk of target organ damage.

背景:高血压急症(HE)是血压不受控制的急性阶段,在发展中国家造成大量心血管疾病发病率和死亡率。在我们的环境中,HE的患病率和高血压危象患者的特征尚不清楚。目的:了解高血压危象住院患者的高血压急症发生率及相关因素。方法:回顾性分析2018年9月至2019年8月在艾德尔综合专科医院(ACSH)住院的收缩压/舒张压升高至180/120 mmHg以上的高血压危重患者的记录,进行横断面研究。连续入组信息完整的患者病历。使用结构化数据收集工具从患者病历中收集社会人口统计学、临床特征和其他相关变量。数据输入和分析使用SPSS版本20。采用Logistic回归确定与HE相关的因素。结果:共有141例诊断为高血压危象的患者被纳入研究;以女性77例(54.6%)为主,居住在城市104例(73.8%)。参与者的平均年龄为58.8岁。42例(29.8%)患者发现HE。静脉滴注肼39(27.7%)和口服钙通道阻滞剂102(72.3%)是急诊急性降压的处方药物。令人惊讶的是,没有高血压史的患者(调整优势比(AOR)=2.469;95%置信区间(CI): 0.176-0.933)和女性(AOR=2.494;95% CI: 1.111-5.596)是HE的独立相关因素。结论:HE患病率占患者的显著比例。因此,高血压患者应严格管理,并推广筛查计划,以降低靶器官损害的风险。
{"title":"Prevalence of Hypertensive Emergency and Associated Factors Among Hospitalized Patients with Hypertensive Crisis: A Retrospective Cross-Sectional Study.","authors":"Desilu Mahari Desta,&nbsp;Dawit Zewdu Wondafrash,&nbsp;Afewerki Gebremeskel Tsadik,&nbsp;Gebremicheal Gebreslassie Kasahun,&nbsp;Segen Tassew,&nbsp;Teklu Gebrehiwot,&nbsp;Solomon Weldegebreal Asgedom","doi":"10.2147/IBPC.S265183","DOIUrl":"https://doi.org/10.2147/IBPC.S265183","url":null,"abstract":"<p><strong>Background: </strong>Hypertensive emergency (HE) is an acute stage of uncontrolled blood pressure which poses a substantial cardiovascular morbidity and mortality in developing countries. In our setting, the prevalence of HE and the characteristics of patients with a hypertensive crisis are not certainly known yet.</p><p><strong>Objective: </strong>The study assessed the prevalence of hypertensive emergency and associated factors among hospitalized patients with hypertensive crisis.</p><p><strong>Methods: </strong>A retrospective cross-sectional study was conducted by reviewing records of patients having a diagnosis of hypertensive crisis with systolic/diastolic blood pressure raised to more than 180/120 mmHg admitted to Ayder Comprehensive Specialized Hospital (ACSH) from September 2018 to August 2019. Patients' medical records with complete information were enrolled consecutively. Socio-demographic, clinical characteristics, and other related variables were collected using a structured data collection tool from patient medical records. Data were entered and analyzed using SPSS version 20. Logistic regression was employed to determine factors associated with HE.</p><p><strong>Results: </strong>A total of 141 patients' records with a diagnosis of a hypertensive crisis were enrolled in the study; the majority were females 77 (54.6%) and residing in the urban setting 104 (73.8%). The mean age of the participants was 58.8 years. HE was found in 42 (29.8%) of patients. Intravenous Hydralazine 39 (27.7%) and oral calcium channel blocker 102 (72.3%) were the prescribed drugs for acute blood pressure reduction in the emergency setting. Surprisingly, patients who had no history of hypertension (adjusted odds ratio (AOR)=2.469; 95% confidence interval (CI): 0.176‒0.933) and female sex (AOR=2.494; 95% CI: 1.111‒5.596) were found to be independently associated factors with HE.</p><p><strong>Conclusion: </strong>The prevalence of HE was found to account a significant proportion of patients. Hence, hypertensive patients should be strictly managed accordingly, and promoting screening programs could reduce the risk of target organ damage.</p>","PeriodicalId":45299,"journal":{"name":"Integrated Blood Pressure Control","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2020-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/IBPC.S265183","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38359643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Resistant Hypertension: Where are We Now and Where Do We Go from Here? 抵抗性高血压:我们的现状与未来?
IF 1.5 Q3 PERIPHERAL VASCULAR DISEASE Pub Date : 2020-08-05 eCollection Date: 2020-01-01 DOI: 10.2147/IBPC.S223334
Mansur K Pathan, Debbie L Cohen

Resistant hypertension is an important subtype of hypertension that leads to an increased risk of cerebrovascular, cardiovascular, and kidney disease. The revised guidelines from the American College of Cardiology and American Heart Association now define resistant hypertension as blood pressure that remains above goal despite use of three maximally titrated anti-hypertensive medications including a diuretic or as a hypertensive patient who requires 4 or more agents for adequate BP control. These agents typically include a calcium-channel blocker, a renin-angiotensin system inhibitor, and a diuretic at maximal or maximally tolerated doses. As recognition of resistant hypertension increases, it is important to distinguish pseudo-resistant or apparent hypertension from true resistant hypertension. Etiologies of apparent resistant hypertension include measurement error and medication non-adherence. The prevalence of true resistant hypertension is likely much lower than reported in the literature when accounting for patients with apparent resistant hypertension. Evaluation of patients with true resistant hypertension includes screening for causes of secondary hypertension and interfering medications. Successful management of resistant hypertension includes lifestyle modification and optimization of medical therapy, often including the use of mineralocorticoid receptor antagonists. Looking ahead at developments in hypertension management, a slew of new device-based therapies are under active development. Of these, renal denervation is the closest to routine clinical application. Further study is needed before these devices can be recommended in the routine treatment of resistant hypertension.

抵抗性高血压是高血压的一个重要亚型,会导致脑血管、心血管和肾脏疾病的风险增加。美国心脏病学会和美国心脏协会修订后的指南现在将耐药性高血压定义为,尽管使用了包括利尿剂在内的三种最大剂量的抗高血压药物,血压仍高于目标值,或者高血压患者需要使用四种或更多药物才能充分控制血压。这些药物通常包括最大剂量或最大耐受剂量的钙通道阻滞剂、肾素-血管紧张素系统抑制剂和利尿剂。随着对抵抗性高血压认识的提高,必须将假性抵抗性高血压或表观高血压与真正的抵抗性高血压区分开来。表观抵抗性高血压的病因包括测量误差和不遵医嘱用药。如果将表面抵抗性高血压患者计算在内,真正抵抗性高血压的患病率可能比文献报道的要低得多。对真正的抵抗性高血压患者的评估包括筛查继发性高血压的病因和干扰药物。成功治疗抵抗性高血压的方法包括改变生活方式和优化药物治疗,通常包括使用矿物质皮质激素受体拮抗剂。展望高血压治疗的未来发展,一系列基于设备的新疗法正在积极开发中。其中,肾脏神经支配是最接近常规临床应用的疗法。在推荐将这些设备用于抵抗性高血压的常规治疗之前,还需要进一步的研究。
{"title":"Resistant Hypertension: Where are We Now and Where Do We Go from Here?","authors":"Mansur K Pathan, Debbie L Cohen","doi":"10.2147/IBPC.S223334","DOIUrl":"10.2147/IBPC.S223334","url":null,"abstract":"<p><p>Resistant hypertension is an important subtype of hypertension that leads to an increased risk of cerebrovascular, cardiovascular, and kidney disease. The revised guidelines from the American College of Cardiology and American Heart Association now define resistant hypertension as blood pressure that remains above goal despite use of three maximally titrated anti-hypertensive medications including a diuretic or as a hypertensive patient who requires 4 or more agents for adequate BP control. These agents typically include a calcium-channel blocker, a renin-angiotensin system inhibitor, and a diuretic at maximal or maximally tolerated doses. As recognition of resistant hypertension increases, it is important to distinguish pseudo-resistant or apparent hypertension from true resistant hypertension. Etiologies of apparent resistant hypertension include measurement error and medication non-adherence. The prevalence of true resistant hypertension is likely much lower than reported in the literature when accounting for patients with apparent resistant hypertension. Evaluation of patients with true resistant hypertension includes screening for causes of secondary hypertension and interfering medications. Successful management of resistant hypertension includes lifestyle modification and optimization of medical therapy, often including the use of mineralocorticoid receptor antagonists. Looking ahead at developments in hypertension management, a slew of new device-based therapies are under active development. Of these, renal denervation is the closest to routine clinical application. Further study is needed before these devices can be recommended in the routine treatment of resistant hypertension.</p>","PeriodicalId":45299,"journal":{"name":"Integrated Blood Pressure Control","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2020-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c6/47/ibpc-13-83.PMC7415451.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38269012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Integrated Blood Pressure Control
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1