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Navigating Cardiometabolic Health Behavior during the Pandemic: Strategies for Metabolic Syndrome Management. 在大流行病期间引导心脏代谢健康行为:代谢综合征管理策略。
IF 4.7 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-06-30 Epub Date: 2024-06-10 DOI: 10.7570/jomes24024
Junghyun Noh
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引用次数: 0
Alpha-Lipoic Acid Induces Adipose Tissue Browning through AMP-Activated Protein Kinase Signaling in Vivo and in Vitro. α-硫辛酸通过体内和体外 AMP 激活蛋白激酶信号诱导脂肪组织褐变
IF 4.7 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-06-30 Epub Date: 2024-05-03 DOI: 10.7570/jomes23048
Shieh-Yang Huang, Ming-Ting Chung, Ching-Wen Kung, Shu-Ying Chen, Yi-Wen Chen, Tong Pan, Pao-Yun Cheng, Hsin-Hsueh Shen, Yen-Mei Lee

Background: AMP-activated protein kinase (AMPK) is a key enzyme for cellular energy homeostasis and improves metabolic disorders. Brown and beige adipose tissues exert thermogenesis capacities to dissipate energy in the form of heat. Here, we investigated the beneficial effects of the antioxidant alpha-lipoic acid (ALA) in menopausal obesity and the underlying mechanisms.

Methods: Female Wistar rats (8 weeks old) were subjected to bilateral ovariectomy (Ovx) and divided into four groups: Sham (n=8), Ovx (n=11), Ovx+ALA2 (n=10), and Ovx+ALA3 (n=6) (ALA 200 and 300 mg/kg/day, respectively; gavage) for 8 weeks. 3T3-L1 cells were used for in vitro study.

Results: Rats receiving ALA2 and ALA3 treatment showed significantly lower levels of body weight and white adipose tissue (WAT) mass than those of the Ovx group. ALA improved plasma lipid profiles including triglycerides, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol. Hematoxylin & eosin staining of inguinal WAT showed that ALA treatment reduced Ovx-induced adipocyte size and enhanced uncoupling protein 1 (UCP1) expression. Moreover, plasma levels of irisin were markedly increased in ALA-treated Ovx rats. Protein expression of brown fat-specific markers including UCP1, PRDM16, and CIDEA was downregulated by Ovx but markedly increased by ALA. Phosphorylation of AMPK, its downstream acetyl-CoA carboxylase, and its upstream LKB1 were all significantly increased by ALA treatment. In 3T3-L1 cells, administration of ALA (100 and 250 μM) reduced lipid accumulation and enhanced oxygen consumption and UCP1 protein expression, while inhibition of AMPK by dorsomorphin (5 μM) significantly reversed these effects.

Conclusion: ALA improves estrogen deficiency-induced obesity via browning of WAT through AMPK signaling.

背景:AMP激活蛋白激酶(AMPK)是细胞能量平衡和改善代谢紊乱的关键酶。棕色和米色脂肪组织具有产热能力,能以热的形式耗散能量。在此,我们研究了抗氧化剂α-硫辛酸(ALA)对更年期肥胖的有益作用及其内在机制:方法:对雌性 Wistar 大鼠(8 周大)进行双侧卵巢切除术(Ovx),并将其分为四组:Sham (n=8), Ovx (n=11), Ovx+ALA2 (n=10), and Ovx+ALA3 (n=6) (ALA 200 and 300 mg/kg/day; gavage) for 8 weeks.体外研究使用 3T3-L1 细胞:结果:接受 ALA2 和 ALA3 治疗的大鼠的体重和白色脂肪组织(WAT)质量水平明显低于卵巢癌组。ALA改善了血浆脂质状况,包括甘油三酯、总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇。腹股沟 WAT 的苏木精和伊红染色显示,ALA 治疗减少了 Ovx 诱导的脂肪细胞体积,并增强了解偶联蛋白 1(UCP1)的表达。此外,经 ALA 处理的 Ovx 大鼠血浆中的鸢尾素水平明显升高。棕色脂肪特异性标志物(包括 UCP1、PRDM16 和 CIDEA)的蛋白表达受 Ovx 的影响而下调,但受 ALA 的影响而显著增加。ALA 处理后,AMPK、其下游乙酰-CoA 羧化酶和上游 LKB1 的磷酸化均显著增加。在 3T3-L1 细胞中,给予 ALA(100 和 250 μM)可减少脂质积累,提高耗氧量和 UCP1 蛋白表达,而用多索吗啡(5 μM)抑制 AMPK 可明显逆转这些效应:结论:ALA可通过AMPK信号转导使WAT褐变,从而改善雌激素缺乏诱导的肥胖。
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引用次数: 0
Muscle Quality as a Potential Diagnostic Marker of Advanced Liver Fibrosis in Patients with Non-alcoholic Fatty Liver Disease. 肌肉质量作为非酒精性脂肪肝患者晚期肝纤维化的潜在诊断指标
IF 4.7 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-06-30 Epub Date: 2024-05-13 DOI: 10.7570/jomes23072
Natsumi Oshida, Sechang Oh, Bokun Kim, Ikuru Miura, Naoyuki Hasegawa, Shoichi Komine, Tomonori Isobe, Junichi Shoda

Background: Muscle-liver crosstalk plays an important role in the development and progression of non-alcoholic fatty liver disease (NAFLD). The measurement of muscle echo-intensity during ultrasonography is a real-time, non-invasive method of assessing muscle quality. In this retrospective study, we investigated the significance of poor muscle quality (namely, a greater mass of non-contractile tissue, including intramuscular fat) as a risk factor for advanced liver fibrosis and considered whether it may represent a useful tool for the diagnosis of advanced liver fibrosis.

Methods: We analyzed data from 307 patients with NAFLD (143 men and 164 women) who visited the University of Tsukuba Hospital between 2017 and 2022. The patients were stratified into the following tertiles of muscle quality according to their muscle echo-intensity on ultrasonography: modest (84.1 arbitrary units [A.U.]), intermediate (97.4 A.U.), and poor (113.6 A.U.). We then investigated the relationships between muscle quality and risk factors for advanced liver fibrosis and calculated appropriate cutoff values.

Results: Patients with poor muscle quality showed a significant, 7.6-fold greater risk of liver fibrosis compared to those with modest muscle quality. Receiver operating characteristic curve analysis showed that muscle quality assessment was as accurate as the fibrosis-4 index and NAFLD fibrosis score in screening for liver fibrosis and superior to the assessment of muscle quantity and strength, respectively. Importantly, a muscle echo-intensity of ≥92.4 A.U. may represent a useful marker of advanced liver fibrosis.

Conclusion: Muscle quality may represent a useful means of identifying advanced liver fibrosis, and its assessment may become a useful screening tool in daily practice.

背景:肌肉与肝脏之间的相互影响在非酒精性脂肪肝(NAFLD)的发生和发展过程中起着重要作用。在超声波检查中测量肌肉回声强度是一种实时、无创的肌肉质量评估方法。在这项回顾性研究中,我们调查了肌肉质量差(即非收缩性组织(包括肌肉内脂肪)的质量较大)作为晚期肝纤维化风险因素的意义,并考虑了它是否可作为诊断晚期肝纤维化的有用工具:我们分析了2017年至2022年期间在筑波大学医院就诊的307名非酒精性脂肪肝患者(男性143人,女性164人)的数据。根据超声波检查的肌肉回声强度,将患者的肌肉质量分为以下三等分:中等(84.1 A.U.)、中等(97.4 A.U.)和较差(113.6 A.U.)。然后,我们研究了肌肉质量与晚期肝纤维化风险因素之间的关系,并计算出了适当的临界值:结果:与肌肉质量一般的患者相比,肌肉质量差的患者发生肝纤维化的风险明显高出7.6倍。接收者操作特征曲线分析表明,在筛查肝纤维化方面,肌肉质量评估与纤维化-4指数和非酒精性脂肪肝纤维化评分一样准确,并分别优于肌肉数量和力量评估。重要的是,肌肉回声强度≥92.4 A.U.可能是晚期肝纤维化的有效标志:肌肉质量可能是识别晚期肝纤维化的有效方法,其评估可能成为日常实践中的有用筛查工具。
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引用次数: 0
Association of Triglyceride Glucose-Derived Indices with Recurrent Events Following Atherosclerotic Cardiovascular Disease. 甘油三酯葡萄糖衍生指数与动脉粥样硬化性心血管疾病复发事件的关系
IF 4.7 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-06-30 Epub Date: 2024-05-08 DOI: 10.7570/jomes23055
Sha Li, Hui-Hui Liu, Yan Zhang, Meng Zhang, Hui-Wen Zhang, Cheng-Gang Zhu, Yuan-Lin Guo, Na-Qiong Wu, Rui-Xia Xu, Qian Dong, Ke-Fei Dou, Jie Qian, Jian-Jun Li

Background: Triglyceride glucose (TyG) and TyG-body mass index (TyG-BMI) are reliable surrogate indices of insulin resistance and used for risk stratification and outcome prediction in patients with atherosclerotic cardiovascular disease (ASCVD). Here, we inserted estimated average glucose (eAG) into the TyG (TyAG) and TyG-BMI (TyAG-BMI) as derived parameters and explored their clinical significance in cardiovascular risk prediction.

Methods: This was a population-based cohort study of 9,944 Chinese patients with ASCVD. The baseline admission fasting glucose and A1C-derived eAG values were recorded. Cardiovascular events (CVEs) that occurred during an average of 38.5 months of follow-up were recorded. We stratified the patients into four groups by quartiles of the parameters. Baseline data and outcomes were analyzed.

Results: Distribution of the TyAG and TyAG-BMI indices shifted slightly toward higher values (the right side) compared with TyG and TyG-BMI, respectively. The baseline levels of cardiovascular risk factors and coronary severity increased with quartile of TyG, TyAG, TyG-BMI, and TyAG-BMI (all P<0.001). The multivariate-adjusted hazard ratios for CVEs when the highest and lowest quartiles were compared from low to high were 1.02 (95% confidence interval [CI], 0.77 to 1.36; TyG), 1.29 (95% CI, 0.97 to 1.73; TyAG), 1.59 (95% CI, 1.01 to 2.58; TyG-BMI), and 1.91 (95% CI, 1.16 to 3.15; TyAG-BMI). The latter two showed statistical significance.

Conclusion: This study suggests that TyAG and TyAG-BMI exhibit more information than TyG and TyG-BMI in disease progression among patients with ASCVD. The TyAG-BMI index provided better predictive performance for CVEs than other parameters.

背景:甘油三酯葡萄糖(TyG)和TyG-体重指数(TyG-BMI)是胰岛素抵抗的可靠替代指标,可用于动脉粥样硬化性心血管疾病(ASCVD)患者的风险分层和结局预测。在这里,我们将估计平均血糖(eAG)作为衍生参数加入到TyG(TyAG)和TyG-BMI(TyAG-BMI)中,并探讨了它们在心血管风险预测中的临床意义:这是一项基于人群的队列研究,研究对象为9944名中国ASCVD患者。研究记录了基线入院空腹血糖和 A1C 导出的 eAG 值。记录了平均 38.5 个月随访期间发生的心血管事件 (CVE)。我们按照参数的四分位数将患者分为四组。对基线数据和结果进行了分析:结果:与TyG和TyG-BMI相比,TyAG和TyAG-BMI指数的分布分别向高值(右侧)轻微偏移。心血管危险因素和冠心病严重程度的基线水平随 TyG、TyAG、TyG-BMI 和 TyAG-BMI 的四分位数增加而增加(均为 PC结论:该研究表明,TyAG 和 TyAG-BMI 指数的基线水平和冠心病严重程度随 TyG 和 TyAG-BMI 的四分位数增加而增加:本研究表明,TyAG和TyAG-BMI比TyG和TyG-BMI更能反映ASCVD患者的疾病进展情况。与其他参数相比,TyAG-BMI 指数能更好地预测 CVE。
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引用次数: 0
Effects of Metabolic Dysfunction-Associated Steatotic Liver Disease on Bone Density and Fragility Fractures: Associations and Mechanisms. 代谢功能障碍相关性脂肪肝对骨密度和脆性骨折的影响:关联与机制
IF 4.7 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-06-30 Epub Date: 2024-05-14 DOI: 10.7570/jomes24004
Shaghayegh Khanmohammadi, Mohammad Shafi Kuchay

Metabolic dysfunction-associated steatotic liver disease (MASLD) has profound adverse effects on bone health and homeostasis. MASLD appears to be associated with changes in bone mineral density (BMD) and fracture rate. However, the data are ambiguous and conflicting. Although several studies have shown that children and adolescents with MASLD have decreased BMD, the data on the prevalence of fragility fractures among children are scarce. In adults, increasing evidence suggests that MASLD decreases BMD and increases the risk of fragility fractures, which appears to be due to deterioration of bone architecture in addition to a decrease in BMD. Effects of MASLD on bone health may also be age- and race-specific. MASLD does not seem to increase fracture risk in children and adolescents but increases the risk of fractures in elderly men, especially those of Asian origin. From a mechanistic perspective, bone remodeling is a continuous process between osteoblasts (bone-forming) and osteoclasts (bone-resorbing), with any imbalance resulting in metabolic bone disease. In individuals with MASLD, loss of anabolic insulin receptor signaling (insulin resistance) in osteoblasts and increased receptor activator of nuclear factor κB (RANK)/RANK ligand signaling in osteoclasts (proinflammatory cytokines) swings the pendulum toward accelerated bone loss. These processes are further complicated by the concomitant presence of obesity, type 2 diabetes mellitus, or sarcopenia in individuals with MASLD. This study reviews the current literature associated with the effects of MASLD on BMD and fragility fractures in children/adolescents and adults. This review also discusses the pathomechanisms that link MASLD with changes in BMD and fragility fractures.

代谢功能障碍相关性脂肪性肝病(MASLD)对骨骼健康和平衡有着深远的不利影响。代谢性脂肪肝似乎与骨矿物质密度(BMD)和骨折率的变化有关。然而,相关数据并不明确且相互矛盾。尽管多项研究表明,患有 MASLD 的儿童和青少年的骨密度会降低,但有关儿童脆性骨折发生率的数据却很少。在成人中,越来越多的证据表明,MASLD 会降低 BMD 并增加脆性骨折的风险,这似乎是由于除 BMD 降低外,骨结构也发生了退化。MASLD 对骨骼健康的影响可能还具有年龄和种族特异性。MASLD似乎不会增加儿童和青少年的骨折风险,但会增加老年男性,尤其是亚裔男性的骨折风险。从机理角度来看,骨重塑是成骨细胞(骨形成)和破骨细胞(骨吸收)之间的一个连续过程,任何失衡都会导致代谢性骨病。在 MASLD 患者中,成骨细胞中合成代谢胰岛素受体信号的缺失(胰岛素抵抗)和破骨细胞中核因子κB 受体激活剂(RANK)/RANK 配体(RANKL)信号的增加(促炎细胞因子)使钟摆摆动,加速骨质流失。如果 MASLD 患者同时患有肥胖症、2 型糖尿病或肌肉疏松症,这些过程就会变得更加复杂。本研究综述了与 MASLD 对儿童/青少年和成人 BMD 和脆性骨折的影响相关的现有文献。本综述还讨论了 MASLD 与 BMD 和脆性骨折变化之间的病理机制。
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引用次数: 0
Relationship between Change in Physical Activity and Risk of Metabolic Syndrome: A Prospective Cohort Study. 运动量变化与代谢综合征风险之间的关系:一项前瞻性队列研究
IF 4.7 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-06-30 Epub Date: 2024-06-10 DOI: 10.7570/jomes24007
Doo Yong Park, On Lee, Yong Ho Lee, Chung Gun Lee, Yeon Soo Kim

Background: This study investigates the relationship between changes in physical activity levels and risk of metabolic syndrome.

Methods: This study examined 1,686 adults aged 40 to 69 years from a community-based cohort study with complete 1st to 4th follow-up data between 2011 and 2020. Changes in physical activity were evaluated through baseline and follow-up surveys using physical activity questionnaires. Metabolic syndrome was diagnosed according to the International Diabetes Federation criteria. A survival analysis was conducted using a multivariate extended Cox regression model with a significance level set at P<0.05.

Results: Participants were divided into groups according to physical activity levels. The newly inactive group (vigorous physical activity ≤150 minutes at first follow-up) had a 36% increase in the hazard ratio (HR) for metabolic syndrome compared with the consistently inactive group (≤150 minutes at both baseline and first follow-up) (HR, 1.36; 95% confidence interval [CI], 1.04 to 1.79). The newly active group (walking ≤420 minutes per week at baseline and >420 minutes per week at first follow-up) had a 25% decrease in the HR for metabolic syndrome compared with the consistently inactive group (walking ≤420 minutes per week at both baseline and first follow-up) (HR, 0.75; 95% CI, 0.57 to 0.98).

Conclusion: Changes in physical activity levels are associated with risk of metabolic syndrome. These results provide important insights for future investigations into the link between physical activity changes and disease occurrence.

背景:本研究调查了体育锻炼水平的变化与代谢综合征风险之间的关系:本研究探讨了体育锻炼水平的变化与代谢综合征风险之间的关系:这项研究调查了 2,814 名 40 至 69 岁的成年人,他们来自一项社区队列研究,在 2011 年至 2020 年期间拥有完整的第 1 次至第 4 次随访数据。通过使用体力活动问卷进行基线调查和随访调查,评估了体力活动的变化。代谢综合征根据国际糖尿病联盟的标准进行诊断。采用多变量扩展 Cox 回归模型进行生存分析,显著性水平设定为 PResults:根据体力活动水平将参与者分为几组。新近不运动组(首次随访时剧烈运动时间≤150分钟)与持续不运动组(基线和首次随访时运动时间均≤150分钟)相比,代谢综合征的危险比(HR)增加了36%(HR,1.36;95%置信区间[CI],1.04至1.79)。新近活跃组(基线时每周步行时间≤420分钟,首次随访时每周步行时间大于420分钟)与持续不活跃组(基线时每周步行时间≤420分钟,首次随访时每周步行时间大于420分钟)相比,代谢综合征的HR下降了25%(HR,0.75;95% CI,0.57至0.98):结论:体力活动水平的变化与代谢综合征的风险有关。这些结果为今后研究体力活动变化与疾病发生之间的联系提供了重要启示。
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引用次数: 0
Association between Weight Change and Incidence of Dyslipidemia in Young Adults: A Retrospective Cohort Study of Korean Male Soldiers. 韩国一家三级医院减肥手术后的信息获取和满意度调查。
IF 5.2 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-03-30 Epub Date: 2024-01-22 DOI: 10.7570/jomes23056
Joon-Young Yoon, Won Ju Park, Hee Kyung Kim, Ho-Cheol Kang, Cheol-Kyu Park, Wonsuk Choi

Background: Recent lifestyle changes have increased the prevalence of dyslipidemia in Korea. Young men are known to have a low awareness of dyslipidemia and a lack of motivation to maintain their weight. However, the association between weight change and dyslipidemia in young adults has not been thoroughly examined.

Methods: Data from the Armed Forces Medical Command Defense Medical Information System database were used. In this study, 15,068 soldiers who underwent private and corporal health examinations between May 2020 and April 2022 were included. The difference in weights between the two different health examinations was used to quantify weight change. Four components of the lipid profile were used to assess dyslipidemia during the corporal health examination.

Results: After adjusting for relevant covariates, weight gain was associated with increased risk of dyslipidemia (adjusted odds ratio [OR], 1.38 [95% confidence interval, CI, 1.15 to 1.64] for the 5% to 10% weight gain group; and OR, 2.02 [95% CI, 1.59 to 2.55] for the ≥10% weight gain group), whereas weight loss was associated with decreased risk (adjusted OR, 0.82 [95% CI, 0.68 to 0.98] for the 5% to 10% weight loss group; and OR, 0.38 [95% CI, 0.27 to 0.53] for the ≥10% weight loss group). In subgroup analysis based on the participants' baseline body mass index, smoking status, regular exercise habits, and hypertension status, there were no significant differences between the subgroups.

Conclusion: Weight change was associated with dyslipidemia in Korean male soldiers. The findings suggest that limiting weight gain in young adults by encouraging a healthy lifestyle may help prevent dyslipidemia.

背景:近年来生活方式的改变增加了韩国血脂异常的发病率。众所周知,年轻男性对血脂异常认识不足,缺乏保持体重的动力。然而,有关青壮年体重变化与血脂异常之间的关系尚未得到深入研究:方法:使用武装部队医学司令部国防医学信息系统数据库中的数据。在这项研究中,纳入了在 2020 年 5 月至 2022 年 4 月期间接受私人体检和体格检查的 15,068 名士兵。两次不同体检之间的体重差异被用来量化体重变化。血脂概况的四个组成部分用于评估体格健康检查期间的血脂异常:结果:在对相关协变量进行调整后,体重增加与血脂异常风险增加有关(体重增加 5%至 10%组的调整赔率[OR]为 1.38 [95% 置信区间,CI,1.15 至 1.64];体重增加≥10%组的调整赔率为 2.02 [95% CI,1.59 至 2.55])。55]),而体重减轻则与风险降低有关(体重减轻 5% 至 10% 组的调整 OR 值为 0.82 [95% CI,0.68 至 0.98];体重减轻 ≥10% 组的 OR 值为 0.38 [95% CI,0.27 至 0.53])。根据参与者的基线体重指数、吸烟状况、定期运动习惯和高血压状况进行的亚组分析显示,亚组之间没有显著差异:结论:韩国男兵的体重变化与血脂异常有关。研究结果表明,通过鼓励健康的生活方式来限制青壮年体重增加可能有助于预防血脂异常。
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引用次数: 0
Effects of a 2-Week Kinect-Based Mixed-Reality Exercise Program on Prediabetes: A Pilot Trial during COVID-19. 基于 Kinect 的两周混合现实运动计划对糖尿病前期的影响:COVID-19 期间的试点试验。
IF 5.2 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-03-30 Epub Date: 2024-01-11 DOI: 10.7570/jomes23040
So Young Ahn, Si Woo Lee, Hye Jung Shin, Won Jae Lee, Jun Hyeok Kim, Hyun-Jun Kim, Wook Song

Background: Pre-diabetes can develop into type 2 diabetes mellitus, but can prevented by regular exercise. However, the outcomes when combining unsupervised Kinect-based mixed-reality (KMR) exercise with continuous glucose monitoring (CGM) remain unclear. Therefore, this single-arm pilot trial examined changes in blood glucose (BG) concentrations over 672 hours (4 weeks), including a 2-week period of KMR exercise and CGM in individuals with pre-diabetes.

Methods: This was a pre-and post-treatment case-control study with nine participants. General questionnaires were administered and body composition, fasting BG concentrations, and 2-hour oral glucose tolerance test (2-OGTT) results were measured pre-and post-treatment. Weekly average glucose concentrations, hyperglycemia rate, hypoglycemia rate, average glucose concentration over time, amount of physical activity, amount of food intake, and pre- and postprandial BG (immediately and 30, 60, 90, and 120 minutes after lunch) were measured over 4 weeks (pre-test, exercise, and post -test weeks). Glucose concentrations were measured before exercising, between sets, and 30 and 60 minutes after exercise during the 2 weeks of unsupervised exercise (3 days/week).

Results: In all participants, body mass index (27.16±2.92 kg/m2), fasting BG (108.00±7.19 mg/dL), 2-OGTT (162.56±18.12 mg/dL), hyperglycemia rate (P=0.040), and 90-minute postprandial BG (P=0.035) were significantly reduced during the 2 exercise weeks, and the 2-OGTT result (P=0.044) and diastolic blood pressure (DBP) (P=0.046) were significantly reduced at the post -test as compared with the pre-test.

Conclusion: This study found that 2 weeks of unsupervised KMR exercise reduced 2-OGTT, DBP, hyperglycemia rate, and 90-minute postprandial BG concentration. We believed this effect could be identified more clearly in studies involving a larger number of participants and longer durations of exercise.

背景:糖尿病前期可发展为 2 型糖尿病,但可通过定期锻炼加以预防。然而,将基于 Kinect 的无监督混合现实(KMR)运动与连续血糖监测(CGM)相结合的结果仍不清楚。因此,这项单臂试验研究了糖尿病前期患者在 672 小时(4 周)内血糖浓度的变化,包括为期 2 周的 KMR 运动和 CGM:这是一项治疗前后的病例对照研究,共有 9 名参与者。研究人员进行了一般问卷调查,并测量了治疗前后的身体成分、空腹血糖浓度和 2 小时口服葡萄糖耐量试验 (2-OGTT) 结果。在 4 周内(测试前、运动周和测试后)测量每周平均血糖浓度、高血糖发生率、低血糖发生率、随时间变化的平均血糖浓度、运动量、食物摄入量以及餐前和餐后血糖(午餐后 30、60、90 和 120 分钟)。在两周的无监督运动期间(每周 3 天),测量了运动前、运动间歇以及运动后 30 和 60 分钟的血糖浓度:所有参与者的体重指数(27.16±2.92 kg/m²)、空腹血糖(108.00±7.19 mg/dL)、2-OGTT(162.56±18.12 mg/dL)、高血糖率(P=0.040)和餐后 90 分钟血糖(P=0.035)在2周的运动过程中明显降低,2-OGTT结果(P=0.044)和舒张压(DBP)(P=0.046)在测试后较测试前明显降低.结论:本研究发现,2 周的无监督 KMR 运动可降低 2-OGTT、DBP、高血糖率和 90 分钟餐后血糖浓度。我们相信,在参与人数更多和运动时间更长的研究中,这种效果会更加明显。
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引用次数: 0
Survey of Information Acquisition and Satisfaction after Bariatric Surgery at a Tertiary Hospital in Korea. 韩国一家三级医院减肥手术后的信息获取和满意度调查。
IF 5.2 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-03-30 Epub Date: 2024-01-12 DOI: 10.7570/jomes23028
Seul-Gi Oh, Seong-A Jeong, Chang Seok Ko, Sa-Hong Min, Chung Sik Gong, In-Seob Lee, Beom Su Kim, Jeong Hwan Yook, Moon-Won Yoo

Background: To determine how patients who underwent bariatric surgery at a tertiary hospital in Korea first considered and then decided to get the surgery and identify information gaps among patients and healthcare professionals.

Methods: This study included 21 patients who underwent bariatric surgery to treat morbid obesity (body mass index [BMI] ≥35 or ≥30 kg/m2 together with obesity-related comorbidities) between August 2020 and February 2022. A telephone interview was conducted with the patients after at least 6 months had elapsed since the surgery. We asked how the patients decided to undergo bariatric surgery. We also inquired about their satisfaction with and concerns about the surgery.

Results: Seventy-one percent of the patients were introduced to bariatric surgery following a recommendation from healthcare professionals, acquaintances, or social media. Most of the patients (52%) decided to undergo bariatric surgery based on recommendations from healthcare professionals in non-surgical departments. Satisfaction with the information provided differed among the patients. Post-surgical concerns were related to postoperative symptoms, weight regain, and psychological illness.

Conclusion: Efforts are needed to raise awareness about bariatric surgery among healthcare professionals and the public. Tailored pre- and postoperative consultation may improve quality of life after bariatric surgery.

背景:在韩国一家三级甲等医院接受减肥手术的患者是如何开始考虑并决定接受手术的?目的:确定在韩国一家三级医院接受减肥手术的患者最初是如何考虑和决定接受手术的,并找出患者和医护人员之间的信息差距:本研究纳入了2020年8月至2022年2月期间接受减肥手术治疗病态肥胖(体重指数[BMI]≥35 kg/m2或≥30 kg/m2并伴有肥胖相关合并症)的21名患者。手术后至少 6 个月后,我们对患者进行了电话访谈。我们询问了患者是如何决定接受减肥手术的。我们还询问了他们对手术的满意度和担忧:71%的患者是在医护人员、熟人或社交媒体的推荐下接受减肥手术的。大多数患者(52%)是在非手术部门医护人员的推荐下决定接受减肥手术的。患者对所提供信息的满意度各不相同。手术后的担忧与术后症状、体重反弹和心理疾病有关:结论:需要努力提高医护人员和公众对减肥手术的认识。有针对性的术前和术后咨询可提高减肥手术后的生活质量。
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引用次数: 0
Obesity in Children and Adolescents: 2022 Update of Clinical Practice Guidelines for Obesity by the Korean Society for the Study of Obesity. 儿童和青少年肥胖症:韩国肥胖症研究学会 2022 年肥胖症临床实践指南更新版。
IF 5.2 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-03-30 Epub Date: 2024-01-09 DOI: 10.7570/jomes23060
Eungu Kang, Yong Hee Hong, Jaehyun Kim, Sochung Chung, Kyoung-Kon Kim, Ji-Hee Haam, Bom Taeck Kim, Eun Mi Kim, Jung Hwan Park, Sang Youl Rhee, Jee-Hyun Kang, Young-Jun Rhie

The prevalence of obesity in children and adolescents has been gradually increasing in recent years and has become a major health problem. Childhood obesity can readily progress to adult obesity. It is associated with obesity-related comorbidities, such as type 2 diabetes mellitus, hypertension, obstructive sleep apnea, non-alcoholic fatty liver disease, and the risk factor for cardiovascular disease. It is important to make an accurate assessment of overweight and obesity in children and adolescents with consideration of growth and development. Childhood obesity can then be prevented and treated using an appropriate treatment goal and safe and effective treatment strategies. This article summarizes the clinical practice guidelines for obesity in children and adolescents that are included in the 8th edition of the Clinical Practice Guidelines for Obesity of the Korean Society for the Study of Obesity.

近年来,儿童和青少年肥胖症的发病率逐渐上升,已成为一个主要的健康问题。儿童肥胖症很容易发展成为成人肥胖症。它与肥胖相关的并发症,如 2 型糖尿病、高血压、阻塞性睡眠呼吸暂停、非酒精性脂肪肝和心血管疾病的危险因素有关。对儿童和青少年的超重和肥胖进行准确评估非常重要,同时要考虑到生长和发育情况。然后,可以通过适当的治疗目标和安全有效的治疗策略来预防和治疗儿童肥胖症。本文总结了韩国肥胖症研究学会肥胖症临床实践指南第八版中关于儿童和青少年肥胖症的临床实践指南。
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引用次数: 0
期刊
Journal of Obesity & Metabolic Syndrome
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