Pub Date : 2022-11-14DOI: 10.1186/s41120-022-00064-3
Inn H. Yuk, T. Koulis, Nidhi Doshi, Kathrin Gregoritza, Constanze Hediger, Vanessa Lebouc-Haefliger, Jamie Giddings, T. Khan
{"title":"Formulation mitigations for particle formation induced by enzymatic hydrolysis of polysorbate 20 in protein-based drug products: insights from a full-factorial longitudinal study","authors":"Inn H. Yuk, T. Koulis, Nidhi Doshi, Kathrin Gregoritza, Constanze Hediger, Vanessa Lebouc-Haefliger, Jamie Giddings, T. Khan","doi":"10.1186/s41120-022-00064-3","DOIUrl":"https://doi.org/10.1186/s41120-022-00064-3","url":null,"abstract":"","PeriodicalId":453,"journal":{"name":"AAPS Open","volume":"22 1","pages":"1-22"},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86804734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.1186/s41120-022-00063-4
C. Becker, M. Boettcher, Uwe Muenster, Stephanie Loewen, M. Lobmeyer, W. Mueck
{"title":"Results from in vitro and in vivo studies evaluating the bioavailability, effects of food, and administration as crushed tablet suspension on vericiguat pharmacokinetics","authors":"C. Becker, M. Boettcher, Uwe Muenster, Stephanie Loewen, M. Lobmeyer, W. Mueck","doi":"10.1186/s41120-022-00063-4","DOIUrl":"https://doi.org/10.1186/s41120-022-00063-4","url":null,"abstract":"","PeriodicalId":453,"journal":{"name":"AAPS Open","volume":"37 1","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84856821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-10DOI: 10.1186/s41120-022-00062-5
Jonathan Chun
{"title":"Stability of levothyroxine tablets in blister packaging versus bottles and vials under simulated in-use conditions","authors":"Jonathan Chun","doi":"10.1186/s41120-022-00062-5","DOIUrl":"https://doi.org/10.1186/s41120-022-00062-5","url":null,"abstract":"","PeriodicalId":453,"journal":{"name":"AAPS Open","volume":"2 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2022-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72609576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.1186/s41120-022-00059-0
S. Cullen, Emma Walsh, V. Gervasi, Dikshitkumar Khamar, T. McCoy
{"title":"Technical transfer and commercialisation of lyophilised biopharmaceuticals — application of lyophiliser characterisation and comparability","authors":"S. Cullen, Emma Walsh, V. Gervasi, Dikshitkumar Khamar, T. McCoy","doi":"10.1186/s41120-022-00059-0","DOIUrl":"https://doi.org/10.1186/s41120-022-00059-0","url":null,"abstract":"","PeriodicalId":453,"journal":{"name":"AAPS Open","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75720358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.1186/s41120-022-00060-7
M. Alvi, Azka Yaqoob, K. Rehman, Syed Muhammad Shoaib, M. Akash
{"title":"PLGA-based nanoparticles for the treatment of cancer: current strategies and perspectives","authors":"M. Alvi, Azka Yaqoob, K. Rehman, Syed Muhammad Shoaib, M. Akash","doi":"10.1186/s41120-022-00060-7","DOIUrl":"https://doi.org/10.1186/s41120-022-00060-7","url":null,"abstract":"","PeriodicalId":453,"journal":{"name":"AAPS Open","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82435002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-27DOI: 10.1186/s41120-022-00061-6
Christopher J. Kemper, D. Behnam, S. Brothers, C. Wahlestedt, C. Volmar, Daniel Bennett, M. Hayward
{"title":"Correction: Safety and pharmacokinetics of a highly bioavailable resveratrol preparation (JOTROL TM)","authors":"Christopher J. Kemper, D. Behnam, S. Brothers, C. Wahlestedt, C. Volmar, Daniel Bennett, M. Hayward","doi":"10.1186/s41120-022-00061-6","DOIUrl":"https://doi.org/10.1186/s41120-022-00061-6","url":null,"abstract":"","PeriodicalId":453,"journal":{"name":"AAPS Open","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73864381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-23DOI: 10.1186/s41120-022-00057-2
Alex W. Jacobitz, Wilfredo Rodezno, Neeraj J. Agrawal
{"title":"Utilizing cross-product prior knowledge to rapidly de-risk chemical liabilities in therapeutic antibody candidates","authors":"Alex W. Jacobitz, Wilfredo Rodezno, Neeraj J. Agrawal","doi":"10.1186/s41120-022-00057-2","DOIUrl":"https://doi.org/10.1186/s41120-022-00057-2","url":null,"abstract":"","PeriodicalId":453,"journal":{"name":"AAPS Open","volume":"223 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73018176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-11DOI: 10.1186/s41120-022-00056-3
Svend Poulsen, L. Jørgensen, P. Galle
{"title":"Heat pre-treatment can abolish anti-drug antibody interference in ligand binding pharmacokinetic assays","authors":"Svend Poulsen, L. Jørgensen, P. Galle","doi":"10.1186/s41120-022-00056-3","DOIUrl":"https://doi.org/10.1186/s41120-022-00056-3","url":null,"abstract":"","PeriodicalId":453,"journal":{"name":"AAPS Open","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83391238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-04DOI: 10.1186/s41120-022-00052-7
Xiaofeng Wang, K. Jamil
{"title":"Pharmacokinetic and pharmacodynamic analyses of terlipressin in patients with hepatorenal syndrome","authors":"Xiaofeng Wang, K. Jamil","doi":"10.1186/s41120-022-00052-7","DOIUrl":"https://doi.org/10.1186/s41120-022-00052-7","url":null,"abstract":"","PeriodicalId":453,"journal":{"name":"AAPS Open","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75837753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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