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Expression of autophagy and apoptosis during orthodontic tooth movement alveolar bone remodeling in rats with varied periodontal conditions 不同牙周条件大鼠正畸牙运动过程中自噬和细胞凋亡的表达
IF 1.9 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-10-03 DOI: 10.1016/j.ortho.2025.101076
Yidan Zhang, Bowen Xu, Chuhan Peng, Linna Bai, Kai Yang

Objective

Orthodontic treatment in periodontitis patients is challenging due to unpredictable bone remodeling and tissue damage. Therefore, this study aimed to investigate the effects of orthodontic force on periodontal ligament cell autophagy, apoptosis, and bone remodeling under various inflammatory states using a rat orthodontic tooth movement (OTM) model.

Material and methods

Seventy-five male Sprague – Dawley rats were used to establish OTM models for the periodontal health, active periodontitis, and stable periodontitis groups. Orthodontic force was applied at twelve weeks of age, with rats euthanized on days 0, 1, 3, 7, and 14 after force application. Microcomputed tomography quantified the OTM distance, alveolar bone crest resorption, and trabecular bone microarchitecture parameters. Immunohistochemistry and tartrate-resistant acid phosphatase staining evaluated the expression levels of inflammation, autophagy, apoptosis, osteogenesis, and osteoclast numbers in the periodontal ligament.

Results

The active periodontitis group exhibited the greatest OTM distance, alveolar bone resorption, and osteoclast activity, along with consistently high inflammatory factor expression. In this group, autophagy-related proteins increased on the tension side but decreased on the compression side, while apoptotic protein expression significantly rose. Osteokine levels were low, with an earlier peak decline observed in the active periodontitis group. The periodontal health group maintained high osteogenic activity, and the stable periodontitis group fell in between the two.

Conclusions

The inflammatory microenvironment in active periodontitis interacts with orthodontic force to disrupt the protective autophagy-apoptosis balance, coinciding with increased tissue destruction. Healthy, stable periodontium shows adaptive remodeling, emphasizing the importance of controlling inflammation before orthodontic treatment. This animal experimental procedure complies with the ARRIVE guidelines, and this research was approved by the Animal Ethics and Welfare Committee of the School of Stomatology, Capital Medical University (No̊ KQYY-202207-005).
目的牙周炎患者的骨重塑和组织损伤难以预测,正畸治疗具有挑战性。因此,本研究旨在通过大鼠正畸牙齿运动(OTM)模型,探讨正畸力对不同炎症状态下牙周韧带细胞自噬、细胞凋亡和骨重塑的影响。材料与方法雄性Sprague - Dawley大鼠75只,分别建立牙周健康组、活动性牙周炎组和稳定性牙周炎组的OTM模型。在12周龄时施加正畸力,在施加正畸力后的第0、1、3、7和14天对大鼠实施安乐死。微计算机断层扫描量化了OTM距离、牙槽骨嵴吸收和骨小梁微结构参数。免疫组织化学和抗酒石酸酸性磷酸酶染色评估牙周韧带炎症、自噬、凋亡、成骨和破骨细胞的表达水平。结果活动性牙周炎组牙外膜距离、牙槽骨吸收、破骨细胞活性最大,炎症因子表达持续高。在该组中,自噬相关蛋白在张力侧升高,而在压缩侧降低,而凋亡蛋白的表达明显升高。骨因子水平较低,在活动性牙周炎组中观察到较早的峰值下降。牙周健康组保持较高的成骨活性,而稳定牙周炎组介于两者之间。结论活动性牙周炎的炎症微环境与正畸力相互作用,破坏保护性自噬-细胞凋亡平衡,导致组织破坏增加。健康、稳定的牙周组织表现出适应性重塑,强调了在正畸治疗前控制炎症的重要性。本动物实验程序符合ARRIVE指南,并经首都医科大学口腔医学院动物伦理与福利委员会批准(No∶KQYY-202207-005)。
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引用次数: 0
Effect of varying thicknesses and temperature changes on shape memory behaviour in 3D DPA versus thermoformed clear aligner materials: An in vitro study 不同厚度和温度变化对3D DPA与热成型透明对准材料形状记忆行为的影响:一项体外研究
IF 1.9 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-10-03 DOI: 10.1016/j.ortho.2025.101073
Venkata Durga Mahendra Tivanani, Swetha Reddy Dalli, Praveen Kumar Varma Datla, Anoosha Manda, Sai Keerthi Velagala, Padma Priya Cv

Background

The present study evaluated the shape memory behaviour of TA-28 compared to PET-G at different thicknesses and temperatures.

Methods

Two materials were tested: thermoformed CA Pro (PET-G) and 3D-printed TA-28 (Graphy, Korea), in 0.5 mm and 0.75 mm thicknesses. A total of 160 aligner strips were fabricated and tested for shape recovery at 30 °C, 37 °C, 40 °C, and 80 °C. Each strip was bent at 100 °C and recovery was measured over 60 minutes using a protractor-based template.

Results

TA-28 exhibited significantly higher shape recovery than PET-G at all temperatures (P  0.001). Recovery increased with temperature and was greatest for the 0.5 mm TA-28 samples. At 37 °C, TA-28 reached up to 60.7% recovery within 60 minutes, while PET-G showed negligible change. Three-way ANOVA revealed significant interactions among material, thickness, and temperature (P = 0.005).

Conclusion

TA-28 aligners demonstrate superior shape memory properties compared to PET-G, particularly at body temperature. TA-28 samples with 0.5 mm thickness recovered faster and to a greater extent, offering more consistent force delivery.

Clinical significance

Directly 3D-printed TA-28 aligners may enhance treatment predictability, reduce patient discomfort, and provide sustained orthodontic force due to their temperature-responsive shape recovery. These findings support the use of smart materials in future orthodontic aligner design.
本研究评估了TA-28与PET-G在不同厚度和温度下的形状记忆行为。方法测试两种材料:热成型CA Pro (PET-G)和3d打印TA-28(韩国,Graphy),厚度分别为0.5 mm和0.75 mm。共制作了160个对准器条带,并在30°C, 37°C, 40°C和80°C下测试了形状恢复。每个条带在100°C下弯曲,使用量角器为基础的模板在60分钟内测量恢复。结果在不同温度下,sta -28的形状恢复明显高于PET-G (P≤0.001)。回收率随温度升高而增加,其中0.5 mm TA-28样品的回收率最高。37℃时,TA-28在60分钟内的回收率高达60.7%,而PET-G的变化可以忽略不计。三因素方差分析显示,材料、厚度和温度之间存在显著的相互作用(P = 0.005)。结论与PET-G相比,ta -28矫正剂具有更好的形状记忆性能,特别是在体温下。0.5 mm厚度的TA-28样品恢复得更快,在更大程度上,提供更一致的力传递。直接3d打印TA-28矫正器可以提高治疗的可预测性,减少患者的不适,并且由于其温度响应形状恢复而提供持续的正畸力。这些发现支持了智能材料在未来正畸矫正器设计中的应用。
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引用次数: 0
Comparison of mechanical properties of in-house manufactured fully customized lingual brackets versus prefabricated brackets: An in vitro study 内部制造的完全定制舌托与预制舌托的机械性能比较:一项体外研究。
IF 1.9 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-30 DOI: 10.1016/j.ortho.2025.101067
Pedro Graziani Olímpio Pereira , Silvio Augusto Bellini-Pereira , Aron Aliaga-Del Castillo , Karina Maria Salvatore Freitas , Marcos Roberto de Freitas , Daniela Garib , Guilherme Janson

Objective

This in vitro study aimed to compare the mechanical properties of fully customized lingual brackets (FCLBs) designed and manufactured in-house using open-source software with two commercially prefabricated lingual brackets.

Material and methods

The FCLBs were designed with Liberteeth 3D, a plug-in within the open-source software Blender 3D. The .stl files of the brackets were printed using a direct laser metal sintering machine. The comparison groups included prefabricated In-Ovation® L (IOL) and New STb™ brackets (STb). The sample included 24 lingual brackets, eight per group. The groups were compared in vitro regarding static and kinetic friction using a universal testing machine, and slot size and surface roughness were evaluated through scanning electron microscopy and non-contact laser profilometry. Intergroup comparisons were performed using Kruskal-Wallis and One-way Analysis of Variance tests.

Results

No differences in static and kinetic friction were found. All tested brackets showed slight deviations in slot sizes compared to the manufacturer's prescription. IOL brackets demonstrated a significantly smaller slot size in both height (MD: −32.17; CI: −56.66, −19.71; P = 0.001) and width (MD: −137.31; CI: −188.46, −105.17; P < 0.001) compared with STb brackets. The FCLBs presented significantly greater surface slot roughness compared with the In-Ovation® (MD: −0.41; CI: −0.49, −0.34; P < 0.001) and New STb™ (MD: −0.39; CI: −0.47, −0.32; P < 0.001) brackets.

Conclusions

The design and manufacture of FCLBs using open-source software is feasible. However, the sintering and surface polishing processes require improvement to achieve optimal clinical outcomes in a future clinical perspective.
目的:本体外研究旨在比较使用开源软件自行设计和制造的完全定制舌托(fclb)与两种商业预制舌托的力学性能。材料和方法:fclb是用开源软件Blender 3D中的插件Liberteeth 3D设计的。的。采用直接激光金属烧结机打印支架的STL文件。对照组包括预制In-Ovation®L (IOL)和New STb™托槽(STb)。样本包括24个舌托,每组8个。在体外用万能试验机比较各组的静摩擦和动摩擦,并通过扫描电子显微镜和非接触激光轮廓术评估狭缝尺寸和表面粗糙度。组间比较采用Kruskal-Wallis检验和单向方差分析检验。结果:静摩擦和动摩擦无明显差异。所有测试的托架显示槽大小与制造商的处方略有偏差。IOL托架在高度(MD: -32.17; CI: -56.66, -19.71; P=0.001)和宽度(MD: -137.31; CI: -188.46, -105.17; P)上的缝隙尺寸均显著减小。结论:采用开源软件设计制造fclb是可行的。然而,烧结和表面抛光工艺需要改进,以达到最佳的临床效果,在未来的临床前景。
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引用次数: 0
Non-surgical treatment of severe anterior open bite, hyperdivergent pattern, and posterior crossbite in an adult with atrophy of the mandibular first molar extraction site: A case report 成人下颌第一磨牙拔牙部位萎缩,严重前牙开咬、超分化、后牙合的非手术治疗1例。
IF 1.9 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-29 DOI: 10.1016/j.ortho.2025.101072
Ahmed S. Khalil, Sherief H. Abdel-Haffiez
Anterior open bite presents a significant challenge in orthodontic treatment due to its multifactorial aetiology. Managing such cases in adult patients is further complicated when additional factors, such as posterior crossbite, are present. Space closure in an atrophic edentulous ridge poses an added challenge due to reduced alveolar bone width and the risk of periodontal compromise. The diagnostic and treatment details of the present case were documented in accordance with the CARE guidelines for clinical case reporting. This case report describes the successful non-surgical management of an 18-year-old female with severe anterior open bite, hyperdivergent facial morphology, bilateral posterior crossbite, and an atrophic mandibular first molar extraction site with a mesially and lingually tipped second molar. The patient declined orthognathic surgery, leading to the consideration of a comprehensive orthodontic approach in conjunction with Miniscrew-Assisted Rapid Palatal Expansion (MARPE) for transverse correction, skeletal anchorage for maxillary molar intrusion, and fixed orthodontic appliances for space closure and molar uprighting. Treatment resulted in a functional occlusion with Class I molar and canine relationships, normal overjet and overbite, and stable transverse correction. The patient received satisfactory facial aesthetics with a harmonious smile and was pleased with the results. The integration of skeletal anchorage enabled effective vertical and transverse correction in an adult patient without orthognathic surgery. Controlled uprighting with intrusion allowed for proper alignment of a tipped mandibular molar, followed by successful protraction across an atrophic ridge.
由于其多因素的病因,前开咬在正畸治疗中提出了一个重大的挑战。在成人患者中,当存在其他因素(如后牙合)时,处理此类病例变得更加复杂。由于牙槽骨宽度的减少和牙周损害的风险,萎缩无牙嵴的间隙闭合带来了额外的挑战。本病例的诊断和治疗细节按照CARE临床病例报告指南进行了记录。本病例报告描述了一名18岁女性的成功非手术治疗,她患有严重的前牙开咬,面部形态超发散,双侧后牙合,下颌第一磨牙拔牙处萎缩,第二磨牙中端和舌端。患者拒绝了正颌手术,导致考虑综合正畸入路,结合mini - crew- assisted Rapid Palatal Expansion (MARPE)进行横向矫正,骨骼支具用于上颌磨牙侵入,固定正畸器具用于间隙关闭和磨牙直立。治疗结果为ⅰ类磨牙和犬齿关系的功能性咬合,正常的覆盖和覆盖咬合,以及稳定的横向矫正。患者接受了满意的面部美容,微笑和谐,并对结果感到满意。骨骼锚固的整合使成人患者在没有正颌手术的情况下进行了有效的垂直和横向矫正。控制直立与侵入允许适当对准下颌尖磨牙,随后通过萎缩脊成功的延伸。
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引用次数: 0
Interdisciplinary management of a skeletal class II, hyperdivergent patient accompanied by multiple missing teeth and severe overeruption with orthodontic assisted space redistribution and implant restoration 1例伴有多颗缺牙和严重萌牙的II类骨超发散患者的跨学科治疗,正畸辅助间隙重新分配和种植体修复。
IF 1.9 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-29 DOI: 10.1016/j.ortho.2025.101062
Tianyi Xie, Boxi Yan
Long-term absence of posterior teeth often leads to significant overeruption of the antagonists, posing a substantial challenge for restorative treatment planning. This case report presents an interdisciplinary approach for a skeletal class II, hyperdivergent patient accompanied by missing maxillary second premolars (15,25), left maxillary second molar (27), mandibular first and second molars (36,37,46,47) and severe overeruption of maxillary first molars (16,17). The maxillary first molars were intruded using both buccal and palatal miniscrews while the existing maxillary spaces were closed. In the mandible, the existing spaces were strategically redistributed through the substitution of third molars for missing second molars, complemented by implant-supported restoration of the first molars. After 35 months of active treatment, well-aligned dentition, ideal intercuspation, and a notably improved facial profile were achieved, which remained stable during the 17 months follow-up. Overeruption resulting from long-standing absence of opposing teeth can be effectively managed through orthodontic intrusion with temporary anchorage devices. The strategic use of existing third molars for space redistribution offers a cost-effective, biologically conservative solution that preserves natural dentition.
后牙长期缺失往往导致拮抗剂明显过度生长,对修复治疗计划提出了实质性的挑战。本病例报告介绍了一种跨学科的方法来治疗骨骼II类,伴有上颌第二前磨牙缺失(15,25),左侧上颌第二磨牙缺失(27),下颌第一和第二磨牙缺失(36,37,46,47)和上颌第一磨牙严重过度萌出(16,17)的超发散患者。上颌第一磨牙在上颌间隙闭合的同时,用颊和腭的微钉侵入第一磨牙。在下颌骨,通过第三磨牙替代缺失的第二磨牙,并辅以种植体修复第一磨牙,策略性地重新分配现有的空间。经过35个月的积极治疗,牙列排列良好,间断理想,面部轮廓明显改善,并在17个月的随访中保持稳定。由于对牙长期缺失导致的溢牙可以通过正畸侵入和临时支抗装置有效地处理。策略性地使用现有的第三磨牙进行空间重新分配提供了一种经济有效的、生物保守的解决方案,可以保护自然牙列。
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引用次数: 0
Mandibular symphysis dimensions among various craniofacial patterns: A systematic review and meta-analysis 不同颅面形态的下颌联合尺寸:系统回顾和荟萃分析
IF 1.9 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-26 DOI: 10.1016/j.ortho.2025.101065
Muhammad Saood , Qasim Khalid , Wajiha Abbas , Umer Hussain , Marium Jamil , Umar Hussain , Alessandra Campobasso , Junad Khan

Objectives

To evaluate and synthesize the available evidence on mandibular symphysis dimensions across different sagittal and vertical craniofacial skeletal patterns.

Methods

Eligibility criteria: cross sectional studies comparing mandibular symphysis dimensions among individuals with different sagittal and vertical skeletal patterns. Information sources: unrestricted literature search of six databases (PubMed, Scopus, Web of Science, LILACs, Cochrane and Google Scholar) was conducted up to April 2025 without language restriction. Risk of bias: the quality assessment of the included studies was conducted using Joanna Briggs Institute tool. Synthesis of results: random-effects meta-analyses were performed using mean differences (MDs) and 95% confidence intervals (CIs). Heterogeneity was assessed using I2 and Tau2 statistics. Subgroup analyses were conducted based on ethnicity, imaging modality, and risk of bias. Publication bias was evaluated.

Results

Included studies: twenty-three cross-sectional studies involving 3313 participants (40.35% male) were included. Synthesis of results: class III subjects showed significantly greater symphysis area (MD = 2.37[1.33, 3.41]), height (MD = 0.75[0.27, 1.22]), and convexity (MD = 3.59[0.69, 6.49]) compared to Class I. Hyperdivergent individuals had increased symphysis height (MD = 1.31[0.53, 2.1]) and reduced width (MD = –1.25[–2.37,–0.12]), while hypodivergent individuals showed reduced height (MD = –0.68[–1.34,–0.03]) and increased width (MD = 1.42[0.41, 2.42]). Subgroup analyses revealed ethnicity and risk of bias as significant modifiers, particularly in Class II and vertical pattern comparisons. No significant publication bias was detected.

Discussion

Limitations of evidence: the inclusion of mostly retrospective studies, presence of growing individuals, inadequate control for confounders, inconsistent age and sex reporting, and limited outcome data restricted the strength and scope of the meta-analysis. Interpretation: symphysis dimensions vary by skeletal pattern, with vertical growth type showing stronger associations than sagittal class.

Registration

PROPSERO (CRD420251049382).
目的评价和综合不同矢状面和垂直面颅骨形态下下颌联合尺寸的现有证据。方法:采用横断面研究比较不同矢状和垂直骨型个体的下颌联合尺寸。信息来源:截至2025年4月,对PubMed、Scopus、Web of Science、LILACs、Cochrane和谷歌Scholar六个数据库进行无限制文献检索,无语言限制。偏倚风险:采用Joanna Briggs Institute工具对纳入研究进行质量评估。结果综合:随机效应荟萃分析采用平均差异(md)和95%置信区间(ci)进行。采用I2和Tau2统计量评估异质性。亚组分析基于种族、成像方式和偏倚风险。评价发表偏倚。结果纳入研究:纳入23项横断面研究,涉及3313名受试者(40.35%为男性)。综合结果:III类受试者联合面积(MD = 2.37[1.33, 3.41])、高度(MD = 0.75[0.27, 1.22])和凸度(MD = 3.59[0.69, 6.49])明显大于i类受试者。高发散个体联合高度(MD = 1.31[0.53, 2.1])增加,联合宽度(MD = -1.25[-2.37, -0.12])减小,低发散个体联合高度(MD = -0.68[-1.34, -0.03])降低,联合宽度(MD = 1.42[0.41, 2.42])增加。亚组分析显示,种族和偏倚风险是重要的修饰因素,特别是在II类和垂直模式比较中。未发现显著的发表偏倚。证据的局限性:纳入的大多是回顾性研究,个体的增长,对混杂因素的控制不足,年龄和性别报告不一致,有限的结果数据限制了meta分析的强度和范围。解释:联合的尺寸因骨骼类型而异,垂直生长类型比矢状生长类型有更强的相关性。RegistrationPROPSERO (CRD420251049382)。
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引用次数: 0
Outcomes assessed in clinical trials concerning orthodontic retention: A scoping review 评估正畸固位临床试验的结果:一项范围综述
IF 1.9 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-25 DOI: 10.1016/j.ortho.2025.101059
Dalya Al-Moghrabi , Sarah Abu Arqub , Lina Alfadil , Nada A. Al-shehri , Selena H.M. Tee , Padhraig S. Fleming

Objectives

To assess outcomes and outcome measurement tools used in randomized controlled trials (RCTs) concerning orthodontic retention, and to evaluate the study and sample characteristics.

Methods

A comprehensive search was undertaken to identify RCTs concerning orthodontic retention in participants of any age, published up to May 17th, 2025. Primary and secondary outcomes were grouped into main domains with associated outcome measurement tool recorded. Data relating to sample characteristics, type of intervention, dropout rate, study setting and duration, and recall intervals were obtained.

Results

Of 1526 papers identified, 129 were included. Dental alignment (n = 38) and arch width changes (n = 30) were the most prevalent primary and secondary outcomes, respectively. Patient-centred outcomes were evaluated in only 33 studies (25.6%). Heterogeneity in outcome measurements was evident for both periodontal and dental alignment outcomes. Most participants were adolescents (n = 63; 48.84%) with most included studies involving comparisons between variants of removable retainers (n = 38; 29.5%). The effects of retainer use were considered in both arches (n = 61; 47.3%) or the mandibular arch alone (n = 51; 39.5%). The average follow-up was 13.04 months with moderate dropout rates (> 10%) reported in 27.9% of the studies.

Conclusions

Orthodontic retention trials primarily focused on short-term dental alignment in the lower arch and generally overlooked patient-centred outcomes. Prolonged follow-up remains the exception with moderate dropout rates typical even in short-term studies.
目的评价正畸固位随机对照试验(RCTs)的结果和测量工具,并评价研究和样本特征。方法对截至2025年5月17日发表的涉及正畸固位的随机对照试验进行全面检索。将主要和次要结果分为主要领域,并记录相关的结果测量工具。获得了与样本特征、干预类型、退出率、研究设置和持续时间以及回忆间隔有关的数据。结果在1526篇文献中,共纳入129篇。牙齿排列(n = 38)和牙弓宽度变化(n = 30)分别是最常见的主要和次要结果。只有33项研究(25.6%)评估了以患者为中心的结果。结果测量的异质性在牙周和牙齿排列结果中都很明显。大多数参与者是青少年(n = 63; 48.84%),大多数纳入的研究涉及可移动固位器的不同类型之间的比较(n = 38; 29.5%)。在两个弓(n = 61, 47.3%)或单独下颌弓(n = 51, 39.5%)中考虑使用固位器的影响。平均随访时间为13.04个月,27.9%的研究报告了中等辍学率(> 10%)。结论正畸固位试验主要关注下牙弓的短期牙位排列,通常忽视了以患者为中心的结果。长期随访仍然是例外,即使在短期研究中也有中等辍学率。
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引用次数: 0
Sella turcica bridging and skeletal sagittal patterns in patients with third molar agenesis: A retrospective observational study 第三磨牙发育不全患者的蝶鞍桥接和骨骼矢状模式:一项回顾性观察研究
IF 1.9 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-25 DOI: 10.1016/j.ortho.2025.101061
Maria Francesca Sfondrini , Maurizio Pascadopoli , Enrico Sangalli , Chiara Falzinella , Andrea Scribante

Objectives

To investigate the associations between sella turcica bridging (STB) and skeletal malocclusion patterns in orthodontic patients with third molar agenesis (TMA).

Methods

Panoramic radiographs were taken from patients aged 8–18 years to identify TMA. All the patients were included between March 2023 and June 2023. Lateral cephalometric radiographs were obtained from both patients with TMA (agenesis group, AG) and those without TMA (control group, CG). Cephalometric measurements between the two groups were compared using the Mann-Whitney U test. The analysis of the sella turcica was carried out on lateral cephalometric radiographs based on Leonardi's classification. Linear regressions were performed between bridging, agenesis, cephalometric measurements, sex and age. Significance was set at P < 0.05.

Results

Four hundred patients were included in the study, 200 for the AG group and 200 for the CG. A statistically significant influence of agenesis on the sella depth measurement, which was on average higher in the AG compared to the CG, was found, particularly in cases of mandibular agenesis. Both ANB and A0B0 were significantly lower in the AG compared to the CG (P < 0.05), especially in the mandibular agenesis subgroup. Although the results are statistically significant for the A0B0 and SNB values, they were not clinically relevant. The intermaxillary angle is generally reduced in AG, indicating a greater tendency towards a hypodivergent skeletal pattern. The values of the joint angles, the total gonial angle, and the upper and lower gonial angles are slightly increased on average in AG compared to CG. The percentage ratio between posterior and anterior facial height is higher in AG compared to CG. The most important finding is that the mandibular body length is significantly shorter in AG.

Conclusions

No significant association was found between TMA and the skeletal parameters of the sella turcica. A possible association was found between TMA and skeletal malocclusions, particularly Class III malocclusions.
目的探讨正畸患者第三磨牙发育不全(TMA)的鞍座桥(STB)与骨骼错颌模式的关系。方法选取8 ~ 18岁患者的x线片进行TMA鉴别。所有患者入组时间为2023年3月至2023年6月。对TMA患者(发育不全组,AG)和未TMA患者(对照组,CG)进行侧位头颅x线片检查。使用Mann-Whitney U检验比较两组之间的头侧测量值。根据Leonardi分类,在侧位头颅x线片上对蝶鞍进行分析。在桥接、发育不全、头颅测量、性别和年龄之间进行线性回归。P <; 0.05为显著性。结果共纳入400例患者,其中AG组200例,CG组200例。研究发现,在统计上,发育不全对鞍深测量有显著的影响,特别是在下颌发育不全的情况下,AG的鞍深测量平均高于CG。AG组ANB和A0B0明显低于CG组(P < 0.05),下颌发育不全亚组尤其明显。虽然结果在A0B0和SNB值上有统计学意义,但它们没有临床相关性。AG的颌间角通常减小,表明更倾向于低发散的骨骼模式。与CG相比,AG组关节角、总角、上角和下角值平均略有增加。AG组面部前后高度的百分比比CG组高。最重要的发现是AG的下颌骨体长明显缩短。结论TMA与蝶鞍骨参数无明显相关性。发现TMA与骨骼错咬合,特别是III类错咬合之间可能存在关联。
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引用次数: 0
Palatal bone thickness in adult patients with different facial patterns: A retrospective cross-sectional CBCT study for orthodontic miniscrew planning 不同面部类型的成人患者腭骨厚度:正畸微型计划的回顾性横断面CBCT研究
IF 1.9 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-25 DOI: 10.1016/j.ortho.2025.101058
Luis Alejandro Guanoluiza Pineida , Marjory Elizabeth Vaca Zapata , Mauricio Aguirre Balseca , Karina Maria Salvatore Freitas , Alex Dario Ganan

Introduction

Effective orthodontic anchorage control plays a crucial role in achieving successful treatment outcomes, particularly in cases involving significant tooth movements. Temporary anchorage devices (TADs) placed in the midpalatal region have become widely used due to their ability to provide absolute skeletal anchorage without depending on patient compliance. However, anatomical variables such as palatal bone thickness and possible variations according to facial pattern are essential considerations during treatment planning.

Objective

To evaluate and compare palatal bone thickness in adult patients with different facial patterns, using cone-beam computed tomography (CBCT), with the aim of identifying possible anatomical differences that may influence TAD placement.

Material and methods

This retrospective, cross-sectional, observational study analyzed 90 CBCT scans obtained between 2022 and 2025 from patients aged 18 to 45 years. The sample was evenly divided into three groups according to facial pattern (30 mesofacial, 30 brachyfacial, and 30 dolichofacial), with equal distribution between sexes and comparable ages. Linear measurements of palatal bone thickness were performed at multiple anteroposterior and lateral reference points using the 3D Slicer 5.8.1 software. Intergroup comparison was performed with Kruskal-Wallis test.

Results

A progressive decrease in palatal bone thickness was observed from anterior to posterior regions across all facial types. No statistically significant differences were found between the groups at any measured location (P > 0.05).

Conclusion

The results suggest that facial pattern does not significantly influence palatal bone thickness in the evaluated regions. Therefore, clinical decisions regarding TAD placement should prioritize individual anatomical characteristics over facial patterns.
有效的正畸支抗控制在获得成功的治疗结果中起着至关重要的作用,特别是在涉及牙齿明显移动的情况下。临时锚定装置(TADs)放置在中腭区已被广泛使用,因为它们能够提供绝对的骨骼锚定而不依赖于患者的依从性。然而,解剖变量,如腭骨厚度和可能的变化,根据面部模式是治疗计划中必不可少的考虑因素。目的利用锥形束ct (cone-beam computed tomography, CBCT)评估和比较不同面部形态成人患者的腭骨厚度,以确定可能影响TAD放置的解剖学差异。材料和方法这项回顾性、横断面、观察性研究分析了2022年至2025年间获得的90份CBCT扫描,患者年龄在18至45岁之间。样本按面部类型平均分为中面组、近面组和多面组,性别和年龄分布均匀。使用3D Slicer 5.8.1软件在多个正侧参考点对腭骨厚度进行线性测量。采用Kruskal-Wallis检验进行组间比较。结果所有面部类型的腭骨厚度均由前向后逐渐减少。各组间在任何测量位置均无统计学差异(P > 0.05)。结论面部形态对腭骨厚度的影响不显著。因此,临床决定TAD的位置应优先考虑个体解剖特征而不是面部特征。
{"title":"Palatal bone thickness in adult patients with different facial patterns: A retrospective cross-sectional CBCT study for orthodontic miniscrew planning","authors":"Luis Alejandro Guanoluiza Pineida ,&nbsp;Marjory Elizabeth Vaca Zapata ,&nbsp;Mauricio Aguirre Balseca ,&nbsp;Karina Maria Salvatore Freitas ,&nbsp;Alex Dario Ganan","doi":"10.1016/j.ortho.2025.101058","DOIUrl":"10.1016/j.ortho.2025.101058","url":null,"abstract":"<div><h3>Introduction</h3><div>Effective orthodontic anchorage control plays a crucial role in achieving successful treatment outcomes, particularly in cases involving significant tooth movements. Temporary anchorage devices (TADs) placed in the midpalatal region have become widely used due to their ability to provide absolute skeletal anchorage without depending on patient compliance. However, anatomical variables such as palatal bone thickness and possible variations according to facial pattern are essential considerations during treatment planning.</div></div><div><h3>Objective</h3><div>To evaluate and compare palatal bone thickness in adult patients with different facial patterns, using cone-beam computed tomography (CBCT), with the aim of identifying possible anatomical differences that may influence TAD placement.</div></div><div><h3>Material and methods</h3><div>This retrospective, cross-sectional, observational study analyzed 90 CBCT scans obtained between 2022 and 2025 from patients aged 18 to 45 years. The sample was evenly divided into three groups according to facial pattern (30 mesofacial, 30 brachyfacial, and 30 dolichofacial), with equal distribution between sexes and comparable ages. Linear measurements of palatal bone thickness were performed at multiple anteroposterior and lateral reference points using the 3D Slicer 5.8.1 software. Intergroup comparison was performed with Kruskal-Wallis test.</div></div><div><h3>Results</h3><div>A progressive decrease in palatal bone thickness was observed from anterior to posterior regions across all facial types. No statistically significant differences were found between the groups at any measured location (<em>P</em> <!-->&gt;<!--> <!-->0.05).</div></div><div><h3>Conclusion</h3><div>The results suggest that facial pattern does not significantly influence palatal bone thickness in the evaluated regions. Therefore, clinical decisions regarding TAD placement should prioritize individual anatomical characteristics over facial patterns.</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"24 1","pages":"Article 101058"},"PeriodicalIF":1.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145128381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does resin removal with different burs after orthodontic debonding influence hydrogen peroxide diffusion, bleaching efficacy, and enamel alterations during tooth bleaching? An in-vitro study 正畸脱粘后用不同毛刺去除树脂会影响过氧化氢扩散、漂白效果和牙齿漂白过程中的牙釉质改变吗?体外研究
IF 1.9 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-09-25 DOI: 10.1016/j.ortho.2025.101060
Byron Carpio-Salvatierra , Mayra Alejandra Nuñez Aldaz , Deisy Cristina Ferreira Cordeiro , Michael Willian Favoreto , Maria José Burbano-Balseca , Paulo Vitor Farago , Alessandro D. Loguercio

Objectives

To evaluate the influence of different burs for residual resin removal after orthodontic debonding on hydrogen peroxide (H2O2) concentration into the pulp chamber, bleaching efficacy and physical changes on the enamel surface following in-office tooth bleaching.

Material and methods

Sixty premolars subjected to bracket installation and debonding were randomized into five groups (n = 12): no bleaching (control), only bleaching, Carbide bur + bleaching (CB), Diamond FF bur + bleaching (DB) and Zirconia bur + bleaching (ZB). All groups, except the control, received bleaching (H2O2 35%). The H2O2 concentration (μg/mL) in the pulp chamber was measured using a UV-Vis spectrophotometer. Bleaching efficacy was assessed by a digital spectrophotometer (ΔEab, ΔE00, and WID) before and after 7 days of bleaching. Enamel surface alterations were analysed by FE-SEM. All data were submitted to statistical analysis (α = 0.05).

Results

The groups submitted to resin removal with CB and ZB post-orthodontic debonding showed a lower H2O2 concentration when compared to the Only Bleaching group after bleaching procedure (P < 0.02). No significant differences were observed in bleaching efficacy between groups submitted to different burs when compared to the Only bleaching group (P > 0.05) across evaluated parameters.

Conclusions

The use of CB and ZB burs to remove residual resin post-orthodontic debonding results in lower H2O2 concentration. However, bleaching efficacy was unaffected by bur type. Notably, ZB burs provided superior enamel surface preservation.
目的评价正畸脱粘后不同牙刺去除残余树脂对牙髓腔内过氧化氢浓度、牙釉质漂白效果及牙釉质表面物理变化的影响。材料与方法将60颗完成托槽安装和脱粘的前磨牙随机分为5组(n = 12):不漂白组(对照组)、只漂白组(对照组)、硬质合金+漂白组(CB组)、金刚石FF +漂白组(DB组)和氧化锆+漂白组(ZB组)。除对照组外,其余各组均进行漂白(H2O2 35%)。用紫外-可见分光光度计测定牙髓腔中H2O2浓度(μg/mL)。漂白效果通过数字分光光度计(ΔEab, ΔE00和WID)在漂白前和7天后进行评估。用FE-SEM分析牙釉质表面变化。所有数据进行统计学分析(α = 0.05)。结果与单纯漂白组相比,CB和ZB树脂去除组正畸脱胶后H2O2浓度较低(P < 0.02)。与仅漂白组相比,经过不同刺痛处理组的漂白效果在评估参数上无显著差异(P > 0.05)。结论使用CB和ZB毛刺去除残留树脂正畸后脱粘,可降低H2O2浓度。然而,漂白效果不受bur类型的影响。值得注意的是,ZB毛刺提供了优越的牙釉质表面保存。
{"title":"Does resin removal with different burs after orthodontic debonding influence hydrogen peroxide diffusion, bleaching efficacy, and enamel alterations during tooth bleaching? An in-vitro study","authors":"Byron Carpio-Salvatierra ,&nbsp;Mayra Alejandra Nuñez Aldaz ,&nbsp;Deisy Cristina Ferreira Cordeiro ,&nbsp;Michael Willian Favoreto ,&nbsp;Maria José Burbano-Balseca ,&nbsp;Paulo Vitor Farago ,&nbsp;Alessandro D. Loguercio","doi":"10.1016/j.ortho.2025.101060","DOIUrl":"10.1016/j.ortho.2025.101060","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the influence of different burs for residual resin removal after orthodontic debonding on hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) concentration into the pulp chamber, bleaching efficacy and physical changes on the enamel surface following in-office tooth bleaching.</div></div><div><h3>Material and methods</h3><div>Sixty premolars subjected to bracket installation and debonding were randomized into five groups (<em>n</em> <!-->=<!--> <!-->12): no bleaching (control), only bleaching, Carbide bur<!--> <!-->+<!--> <!-->bleaching (CB), Diamond FF bur<!--> <!-->+<!--> <!-->bleaching (DB) and Zirconia bur<!--> <!-->+<!--> <!-->bleaching (ZB). All groups, except the control, received bleaching (H<sub>2</sub>O<sub>2</sub> 35%). The H<sub>2</sub>O<sub>2</sub> concentration (μg/mL) in the pulp chamber was measured using a UV-Vis spectrophotometer. Bleaching efficacy was assessed by a digital spectrophotometer (ΔE<sub>ab</sub>, ΔE<sub>00</sub>, and WI<sub>D</sub>) before and after 7 days of bleaching. Enamel surface alterations were analysed by FE-SEM. All data were submitted to statistical analysis (α<!--> <!-->=<!--> <!-->0.05).</div></div><div><h3>Results</h3><div>The groups submitted to resin removal with CB and ZB post-orthodontic debonding showed a lower H<sub>2</sub>O<sub>2</sub> concentration when compared to the Only Bleaching group after bleaching procedure (<em>P</em> <!-->&lt;<!--> <!-->0.02). No significant differences were observed in bleaching efficacy between groups submitted to different burs when compared to the Only bleaching group (<em>P</em> <!-->&gt;<!--> <!-->0.05) across evaluated parameters.</div></div><div><h3>Conclusions</h3><div>The use of CB and ZB burs to remove residual resin post-orthodontic debonding results in lower H<sub>2</sub>O<sub>2</sub> concentration. However, bleaching efficacy was unaffected by bur type. Notably, ZB burs provided superior enamel surface preservation.</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"24 1","pages":"Article 101060"},"PeriodicalIF":1.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145160265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
International Orthodontics
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