FARMACIA HOSPITALARIA最新文献

{"title":"Diseño del plan de acogida al paciente (onboarding) en una unidad multidisciplinar de asma grave","authors":"Hilario Martínez-Barros ,&nbsp;María Muñoz-García ,&nbsp;Darío Antolín-Amérigo ,&nbsp;Silvia Sánchez-Cuéllar ,&nbsp;Ana Morales-Tirado ,&nbsp;Ana de-Andrés-Martín ,&nbsp;Gonzalo de-los-Santos-Granados ,&nbsp;Laura Yeguas-Ramírez ,&nbsp;Enrique Blitz-Castro ,&nbsp;Alfonso Santamaría-Gadea ,&nbsp;Belén de-la-Hoz-Caballer ,&nbsp;Sagrario Martín-Aragón ,&nbsp;David González-de-Olano ,&nbsp;Ana María Álvarez-Díaz","doi":"10.1016/j.farma.2025.07.003","DOIUrl":"10.1016/j.farma.2025.07.003","url":null,"abstract":"<div><h3>Objetives</h3><div>To design the patient onboarding in a multidisciplinary severe asthma unit, according to the needs identified by patients and professionals in the unit.</div></div><div><h3>Methods</h3><div>Qualitative study using the human-centred design conducted between November 2022 and February 2023. Patients and professionals from the severe asthma unit and experts in the methodology participated. Three workshops were held. In the first, we elaborated the patient experience map, identifying positive aspects and needs. Possible solutions were devised. In the second, we selected the solutions described in a previous project applicable to onboarding and determined the key moments. In the third, we finalised the definition of the key moments, the professionals in charge in each step and the tools to be incorporated. Finally, in short sessions (sprints) we developed the necessary material and infographics.</div></div><div><h3>Results</h3><div>We identified the main needs of patients (better control of the disease and autonomy in care, two-way conversation with professionals and receiving coordinated and personalised care) and professionals (defining, structuring, unifying and adapting the information provided to patients and managing to maintain open conversations with them). We determined that onboarding should establish a controlled welcome to the severe asthma unit, which is identifiable by patients, promotes the patient-professional relationship and the learning, use and functioning of the severe asthma unit.</div><div>Previously devised solutions applicable to onboarding, such as the landing kit or the patient diary, were selected. We established the key moments of onboarding (identification consultation, initial consultation, onboarding consultation and complementary consultations), the professionals involved and the necessary information, material and infographics.</div><div>Finally, we developed the design, structure and final content of the necessary tools, such as the patient diary or the asthma infographic.</div></div><div><h3>Conclusions</h3><div>This work has allowed us to design, structure and standardise the onboarding, providing an environment that facilitates self-care and open, empathetic, two-way conversation between patients and professionals, according with the key needs expressed by both. These findings may be useful for other multidisciplinary care units.</div></div>","PeriodicalId":45860,"journal":{"name":"FARMACIA HOSPITALARIA","volume":"50 1","pages":"Pages 16-22"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Translated article] Reduction of unnecessary repackaging as an environmental sustainability measure","authors":"David García-Martínez ,&nbsp;Manuela Martínez-Camacho ,&nbsp;Aida Rueda-Naharro ,&nbsp;David García-Marco","doi":"10.1016/j.farma.2025.10.012","DOIUrl":"10.1016/j.farma.2025.10.012","url":null,"abstract":"<div><h3>Objective</h3><div>The main objective is to describe the project and evaluate the impact of replacing repackaged medications with unit dose presentations in 15 public hospitals within a regional health system. Secondary objectives include identifying differences in the changes implemented across the 15 audited hospitals and conducting an exploratory analysis of the potential impact in other non-audited centers that requested participation in the project.</div></div><div><h3>Method</h3><div>A database containing over 2,000 medications available in unit dose format was developed and is updated monthly. In parallel, an automated system based on decision-making algorithms was implemented to identify improvement opportunities in medication procurement. The system was adopted either individually by hospitals or through centralized structures at the regional or private level. The analysis included data from 15 public hospitals, where the reduction in repackaging and its environmental, economic, and operational impact were assessed by measuring material, time, and cost savings. The results were subsequently extrapolated to the 172 hospitals that applied.</div></div><div><h3>Results</h3><div>In the 15 monitored hospitals, repackaging of approximately 1.27 million tablets per year was avoided, resulting in estimated savings of 17,016 km of packaging material, 866 kg in weight, and 113,693 min of labor. The avoided costs in materials and machinery amounted to 36,274€ annually. No statistically significant differences were observed in project adoption across the hospitals (<em>p</em> = 0.234). The extrapolation to 172 hospitals suggests a potential impact of 16.67 million tablets no longer requiring repackaging per year, with an estimated savings of 2220.13 km of material, 24,723 h of labor, and 451,768€ annually.</div></div><div><h3>Conclusions</h3><div>Replacing repackaged medications with commercially available unit dose formats significantly reduced material consumption, labor time, and repackaging-related costs in the evaluated hospitals. The implementation of the project was consistent across the 15 monitored hospitals. Furthermore, the model proved to be scalable. The main limitation identified was the limited availability of unit dose medications on the market; therefore, it is recommended to prioritize their inclusion in procurement processes and to promote their development by the pharmaceutical industry.</div></div>","PeriodicalId":45860,"journal":{"name":"FARMACIA HOSPITALARIA","volume":"50 1","pages":"Pages T43-T46"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145524635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diseño y validación del índice de fragilidad IF-CSS basado en la valoración geriátrica integral para su aplicación en centros sociosanitarios","authors":"Juan Francisco Peris-Martí ,&nbsp;Elia M. Fernández-Villalba ,&nbsp;Patricia Bravo-José ,&nbsp;Carmen Isabel Sáez-Lleó ,&nbsp;Minerva Espert-Roig ,&nbsp;Pilar Martínez-Antequera","doi":"10.1016/j.farma.2025.06.002","DOIUrl":"10.1016/j.farma.2025.06.002","url":null,"abstract":"<div><h3>Objective</h3><div>To validate the IF-CSS frailty index according to its predictive capacity for mortality and to define the intervals compatible with frailty states.</div></div><div><h3>Methods</h3><div>An observational, retrospective, multicenter study of a cohort of elderly patients from four nursing homes with a follow up between 12 and 38 months was conducted. The IF-CSS comprised 17 variables across four domains from the comprehensive geriatric assessment. Contrast of hypothesis log-rank for survival curves according to IF-CSS index was performed. The predictive model of survival time was performed using a parametric accelerated failure model.</div></div><div><h3>Results</h3><div>535 patients with a mean age of 83.62 years (DE±<!--> <!-->7.84) were included. Mortality rate during the study period was 39.8%. Survival curves by frailty intervals showed significant differences (<em>χ</em>² = 92; <em>p</em> &lt; 0.001). The comparative analysis also showed significant differences for almost all the variables included in the construct. The parametric model of accelerated failure estimated a 29% reduction in survival time for each tenth of an increase in the IF-CSS.</div></div><div><h3>Conclusions</h3><div>The IF-CSS results in a tool with a frailty discriminative and mortality predictive capacity that allows its use in the care programs of nursing homes.</div></div>","PeriodicalId":45860,"journal":{"name":"FARMACIA HOSPITALARIA","volume":"50 1","pages":"Pages 23-30"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144620793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribución del metabolito N-óxido en la monitorización terapéutica de voriconazol en un paciente con aspergilosis invasiva","authors":"Irene Orozco Cifuentes,&nbsp;Adrián Domínguez García,&nbsp;María Jiménez Meseguer,&nbsp;Elena García Benayas,&nbsp;Benito García Díaz","doi":"10.1016/j.farma.2025.05.012","DOIUrl":"10.1016/j.farma.2025.05.012","url":null,"abstract":"","PeriodicalId":45860,"journal":{"name":"FARMACIA HOSPITALARIA","volume":"50 1","pages":"Pages 64-66"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Translated article] Evaluation of penicillin allergy labeling in the emergency department: Retrospective study on the impact of a hospital pharmacist-led intervention algorithm","authors":"Fernando Salazar González ,&nbsp;Mireia Iglesias Rodrigo ,&nbsp;Gemma Garreta Fontelles ,&nbsp;Mireia Mensa Vendrell ,&nbsp;Jordi Nicolás Picó","doi":"10.1016/j.farma.2025.10.002","DOIUrl":"10.1016/j.farma.2025.10.002","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the impact of an intervention algorithm on penicillin allergy label reassessment in emergency department patients, aiming to optimize antibiotic selection and improve patient safety.</div></div><div><h3>Methods</h3><div>A retrospective observational study was conducted in a 450-bed hospital, including adult patients with a penicillin allergy label admitted to the emergency department between November 2023 and August 2024. An algorithm developed by the pharmacy service in collaboration with the ASP team was applied, based on validated tools such as the Penicillin Allergy De-Labelling Toolkit, PEN-FAST, and Antibiotic Allergy Assessment Tool. Demographic data, allergy history, and clinical outcomes were collected. The acceptance of recommendations and the incidence of adverse reactions were analyzed.</div></div><div><h3>Results</h3><div>A total of 66 patients were evaluated. Delabeling was proposed in 35 (53.03%) patients, skin testing in 13 (19.69%), oral provocation testing in 9 (13.63%), and label maintenance in 9 (13.63%). A total of 89.39% of the recommendations were accepted, achieving effective delabeling in 42 patients. No adverse reactions were recorded. In 21 cases, antibiotic therapy was optimized following the intervention.</div></div><div><h3>Conclusions</h3><div>The implementation of a structured algorithm for penicillin allergy reassessment in emergency settings is both effective and safe. Its application facilitates antibiotic optimization, improves patient safety, and reduces broad-spectrum antibiotic use. This study highlights the role of hospital pharmacists in drug allergy management and antimicrobial stewardship.</div></div>","PeriodicalId":45860,"journal":{"name":"FARMACIA HOSPITALARIA","volume":"50 1","pages":"Pages T10-T15"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145757852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Translated article] Achievements and challenges ahead for the journal Farmacia Hospilataria","authors":"Teresa Bermejo Vicedo,&nbsp;Maria Queralt Gorgas,&nbsp;Luis Margusino Framiñan","doi":"10.1016/j.farma.2025.11.009","DOIUrl":"10.1016/j.farma.2025.11.009","url":null,"abstract":"","PeriodicalId":45860,"journal":{"name":"FARMACIA HOSPITALARIA","volume":"50 1","pages":"Pages T1-T2"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Translated article] Designing a patient onboarding in a multidisciplinary severe asthma unit","authors":"Hilario Martínez-Barros ,&nbsp;María Muñoz-García ,&nbsp;Darío Antolín-Amérigo ,&nbsp;Silvia Sánchez-Cuéllar ,&nbsp;Ana Morales-Tirado ,&nbsp;Ana de-Andrés-Martín ,&nbsp;Gonzalo de-los-Santos-Granados ,&nbsp;Laura Yeguas-Ramírez ,&nbsp;Enrique Blitz-Castro ,&nbsp;Alfonso Santamaría-Gadea ,&nbsp;Belén de-la-Hoz-Caballer ,&nbsp;Sagrario Martín-Aragón ,&nbsp;David González-de-Olano ,&nbsp;Ana María Álvarez-Díaz","doi":"10.1016/j.farma.2025.10.009","DOIUrl":"10.1016/j.farma.2025.10.009","url":null,"abstract":"<div><h3>Objetives</h3><div>To design the patient onboarding in a multidisciplinary severe asthma unit, according to the needs identified by patients and professionals in the unit.</div></div><div><h3>Methods</h3><div>Qualitative study using the human-centred design conducted between November 2022 and February 2023. Patients and professionals from the severe asthma unit and experts in the methodology participated. Three workshops were held. In the first, we elaborated the patient experience map, identifying positive aspects and needs. Possible solutions were devised. In the second, we selected the solutions described in a previous project applicable to onboarding and determined the key moments. In the third, we finalised the definition of the key moments, the professionals in charge in each step and the tools to be incorporated. Finally, in short sessions (sprints) we developed the necessary material and infographics.</div></div><div><h3>Results</h3><div>We identified the main needs of patients (better control of the disease and autonomy in care, two-way conversation with professionals and receiving coordinated and personalised care) and professionals (defining, structuring, unifying and adapting the information provided to patients and managing to maintain open conversations with them). We determined that onboarding should establish a controlled welcome to the severe asthma unit, which is identifiable by patients, promotes the patient-professional relationship and the learning, use and functioning of the severe asthma unit.</div><div>Previously devised solutions applicable to onboarding, such as the landing kit or the patient diary, were selected. We established the key moments of onboarding (identification consultation, initial consultation, onboarding consultation and complementary consultations), the professionals involved and the necessary information, material and infographics.</div><div>Finally, we developed the design, structure and final content of the necessary tools, such as the patient diary or the asthma infographic.</div></div><div><h3>Conclusions</h3><div>This work has allowed us to design, structure and standardise the onboarding, providing an environment that facilitates self-care and open, empathetic, two-way conversation between patients and professionals, according with the key needs expressed by both. These findings may be useful for other multidisciplinary care units.</div></div>","PeriodicalId":45860,"journal":{"name":"FARMACIA HOSPITALARIA","volume":"50 1","pages":"Pages T16-T22"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145453818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Translated article] Contribution of N-oxide metabolite in the therapeutic drug monitoring of voriconazole in a patient with invasive aspergillosis","authors":"Irene Orozco Cifuentes,&nbsp;Adrián Domínguez García,&nbsp;María Jiménez Meseguer,&nbsp;Elena García Benayas,&nbsp;Benito García Díaz","doi":"10.1016/j.farma.2025.05.019","DOIUrl":"10.1016/j.farma.2025.05.019","url":null,"abstract":"","PeriodicalId":45860,"journal":{"name":"FARMACIA HOSPITALARIA","volume":"50 1","pages":"Pages T64-T66"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluación de etiquetas de alergia a penicilinas en urgencias: estudio retrospectivo del impacto de un algoritmo de intervención liderado por farmacéuticos hospitalarios","authors":"Fernando Salazar González ,&nbsp;Mireia Iglesias Rodrigo ,&nbsp;Gemma Garreta Fontelles ,&nbsp;Mireia Mensa Vendrell ,&nbsp;Jordi Nicolás Picó","doi":"10.1016/j.farma.2025.05.013","DOIUrl":"10.1016/j.farma.2025.05.013","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the impact of an intervention algorithm on penicillin allergy label reassessment in emergency department patients, aiming to optimize antibiotic selection and improve patient safety.</div></div><div><h3>Methods</h3><div>A retrospective observational study was conducted in a 450-bed hospital, including adult patients with a penicillin allergy label admitted to the emergency department between November 2023 and August 2024. An algorithm developed by the pharmacy service in collaboration with the ASP team was applied, based on validated tools such as the Penicillin Allergy De-Labelling Toolkit, PEN-FAST, and Antibiotic Allergy Assessment Tool. Demographic data, allergy history, and clinical outcomes were collected. The acceptance of recommendations and the incidence of adverse reactions were analyzed.</div></div><div><h3>Results</h3><div>A total of 66 patients were evaluated. Delabeling was proposed in 35 (53.03%) patients, skin testing in 13 (19.69%), oral provocation testing in 9 (13.63%), and label maintenance in 9 (13.63%). A total of 89.39% of the recommendations were accepted, achieving effective delabeling in 42 patients. No adverse reactions were recorded. In 21 cases, antibiotic therapy was optimized following the intervention.</div></div><div><h3>Conclusions</h3><div>The implementation of a structured algorithm for penicillin allergy reassessment in emergency settings is effective and safe. Its application facilitates antibiotic optimization, improves patient safety, and reduces broad-spectrum antibiotic use. This study highlights the role of hospital pharmacists in drug allergy management and antimicrobial stewardship.</div></div>","PeriodicalId":45860,"journal":{"name":"FARMACIA HOSPITALARIA","volume":"50 1","pages":"Pages 10-15"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autorización de medicamentos de uso off-label en un hospital de tercer nivel: perspectiva de 5 años","authors":"Lupe Rodríguez-de Francisco,&nbsp;Ángela María Villalba-Moreno,&nbsp;Eva Rocío Alfaro-Lara","doi":"10.1016/j.farma.2025.05.018","DOIUrl":"10.1016/j.farma.2025.05.018","url":null,"abstract":"<div><h3>Introduction</h3><div>The off-label use of drugs requires scientific support to balance risk/benefit, being limited to exceptional cases in which there are no therapeutic alternatives.</div></div><div><h3>Methods</h3><div>Retrospective descriptive study of the reports of the Pharmacy and Therapeutics Committee between 2018 and 2022 in a third level hospital; analyzing the requests, drugs, final opinion, reasons, level of evidence and economic impact.</div></div><div><h3>Results</h3><div>A total of 124 reports were analyzed, highlighting oncohematological (41.9%) and autoimmune (27.4%) diseases as main indications. Oncology (37.1%) and Pediatrics (18.5%) were the main applicants, with 87.9% for antineoplastic and immunomodulatory drugs. A total of 74.2% of the applications were approved due to lack of alternatives and solid evidence (phase II-III trials), while 25.8% were denied due to the availability of therapeutic options or insufficient evidence. In terms of cost, 53% of oncohematological drugs cost between €10,000–50,000/treatment and 62.1% of non-oncohematological drugs cost between €1,000–10,000/year. Approval of the rejected treatments would have generated an additional expenditure of €2,272,603.</div></div><div><h3>Conclusion</h3><div>An increase of up to four times in the evaluation of <em>off-label</em> use drugs was evidenced, with a high approval rate.</div></div>","PeriodicalId":45860,"journal":{"name":"FARMACIA HOSPITALARIA","volume":"50 1","pages":"Pages 38-42"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}