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Randomized Controlled Study Comparing Use of Propofol Plus Fentanyl versus Midazolam Plus Fentanyl as Sedation in Diagnostic Endoscopy in Patients with Advanced Liver Disease. 比较丙泊酚加芬太尼与咪达唑仑加芬太尼在晚期肝病患者诊断内窥镜中的镇静作用的随机对照研究
IF 1.8 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2017-01-01 Epub Date: 2017-09-26 DOI: 10.1155/2017/8462756
Sameh Abdelkhalik Ahmed, Amal Selim, Nehad Hawash, Ahmed Khaled Tawfik, Mohamed Yousef, Abdelrahman Kobtan, Rehab Badawi, Sally Elnawasany, Reham Abdelkader Elkhouly, Amr Shaaban Hanafy, Fatma H Rizk, Loai Mansour, Sherief Abd-Elsalam

Objectives: We aimed to investigate the safety and efficacy of propofol plus fentanyl versus midazolam plus fentanyl as sedative for patients with advanced liver disease presented for gastrointestinal endoscopy.

Methods: A total of 100 patients with liver cirrhosis referred for upper endoscopy were enrolled and divided equally in two groups, midazolam plus fentanyl group and propofol plus fentanyl group. All patients were subjected to history taking, estimation of level of sedation, endoscopist rating, and hemodynamic parameters including oxygen saturation, heart rate, mean arterial pressure, incidence of side effect as (bradycardia, hypotension, hypoxia, nausea and vomiting, cough, shivering, or diplopia), time needed for complete recovery, and time needed for discharge.

Results: There was no statistical significant difference between the studied groups regarding age, sex, weight, Child-Pugh classification score, type and duration of endoscopic intervention, time needed for complete recovery, or time needed for discharge. Complication rates were similar in both groups except for mean arterial blood pressure which was significantly lower in group of patients receiving propofol and fentanyl (P = 0.001).

Conclusion: The use of either propofol or midazolam in combination to fentanyl is effective in sedation of patients with advanced liver diseases presented for upper GIT endoscope. The trial is registered with ClinicalTrials.gov Identifier: NCT03063866.

目的:我们旨在研究异丙酚加芬太尼与咪达唑仑加芬太尼作为胃肠道内窥镜检查的晚期肝病患者的镇静剂的安全性和有效性。方法:选取100例肝硬化上内镜患者,平均分为咪达唑仑加芬太尼组和异丙酚加芬太尼组。所有患者均接受病史记录、镇静水平评估、内镜评估和血流动力学参数,包括血氧饱和度、心率、平均动脉压、副作用发生率(心动过缓、低血压、缺氧、恶心呕吐、咳嗽、寒战或复视)、完全恢复所需时间和出院所需时间。结果:两组患者在年龄、性别、体重、Child-Pugh分级评分、内镜干预类型及持续时间、完全恢复时间、出院时间等方面差异均无统计学意义。两组的并发症发生率相似,但异丙酚和芬太尼组的平均动脉血压明显低于对照组(P = 0.001)。结论:异丙酚或咪达唑仑联合芬太尼可有效镇静上消化道内窥镜下晚期肝病患者。该试验已在ClinicalTrials.gov注册,注册号:NCT03063866。
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引用次数: 7
Imaging the Abdominal Manifestations of Cystic Fibrosis. 囊性纤维化的腹部影像学表现。
IF 1.8 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2017-01-01 Epub Date: 2017-01-29 DOI: 10.1155/2017/5128760
C D Gillespie, M K O'Reilly, G N Allen, S McDermott, V O Chan, C A Ridge

Cystic fibrosis (CF) is a multisystem disease with a range of abdominal manifestations including those involving the liver, pancreas, and kidneys. Recent advances in management of the respiratory complications of the disease has led to a greater life expectancy in patients with CF. Subsequently, there is increasing focus on the impact of abdominal disease on quality of life and survival. Liver cirrhosis is the most important extrapulmonary cause of death in CF, yet significant challenges remain in the diagnosis of CF related liver disease. The capacity to predict those patients at risk of developing cirrhosis remains a significant challenge. We review representative abdominal imaging findings in patients with CF selected from the records of two academic health centres, with a view to increasing familiarity with the abdominal manifestations of the disease. We review their presentation and expected imaging findings, with a focus on the challenges facing diagnosis of the hepatic manifestations of the disease. An increased familiarity with these abdominal manifestations will facilitate timely diagnosis and management, which is paramount to further improving outcomes for patients with cystic fibrosis.

囊性纤维化(CF)是一种多系统疾病,包括肝脏、胰腺和肾脏在内的一系列腹部表现。近年来,该病呼吸系统并发症的治疗取得了进展,使得CF患者的预期寿命延长。随后,人们越来越关注腹部疾病对生活质量和生存的影响。肝硬化是CF中最重要的肺外死亡原因,但CF相关肝病的诊断仍面临重大挑战。预测那些有肝硬化风险的患者的能力仍然是一个重大挑战。我们回顾从两个学术健康中心的记录中选择的CF患者的代表性腹部影像学发现,以期增加对该疾病腹部表现的熟悉程度。我们回顾他们的表现和预期的影像学结果,重点是肝病表现诊断面临的挑战。增加对这些腹部表现的熟悉将有助于及时诊断和治疗,这对进一步改善囊性纤维化患者的预后至关重要。
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引用次数: 15
Cardiovascular Autonomic Dysfunction in Patients of Nonalcoholic Fatty Liver Disease 非酒精性脂肪肝患者的心血管自主神经功能障碍
IF 1.8 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2016-12-08 DOI: 10.1155/2016/5160754
M. Kumar, Akanksha Singh, A. Jaryal, P. Ranjan, K. Deepak, Sanjay Sharma, R. Lakshmy, R. Pandey, N. Vikram
Aim. The present study was designed to evaluate the heart rate variability (HRV) in nonalcoholic fatty liver disease (NAFLD) and to assess the effect of grade of NAFLD and diabetic status on HRV. Methods. This cross-sectional study included 75 subjects (25 NAFLD without diabetes, 25 NAFLD with diabetes, and 25 controls). Measurements included anthropometry, body composition analysis, estimation of plasma glucose, serum lipids, hsCRP, and serum insulin. HRV analysis was performed in both time and frequency domains. Results. The time and frequency domain indices of overall variability (SDNN, total power) were significantly lower in NAFLD with diabetes as compared to the controls. However, the LF : HF ratio did not differ among the three groups. The variables related to obesity, lipid profile, and glucose metabolism were also higher in NAFLD with diabetes and those with Grade II NAFLD without diabetes, as compared to controls. Multivariate stepwise regression analysis showed a negative correlation between HRV and total cholesterol and fat percentage. Conclusion. The grade of NAFLD as well as diabetic status contributes to the decrease in the cardiovascular autonomic function, with diabetic status rather than grade of NAFLD playing a critical role. Serum lipids and adiposity may also contribute to cardiac autonomic dysfunction.
的目标。本研究旨在评估非酒精性脂肪性肝病(NAFLD)的心率变异性(HRV),并评估NAFLD分级和糖尿病状态对HRV的影响。方法。这项横断面研究包括75名受试者(25名非糖尿病NAFLD, 25名合并糖尿病NAFLD和25名对照)。测量包括人体测量、身体成分分析、血浆葡萄糖、血脂、hsCRP和血清胰岛素的估计。在时域和频域进行HRV分析。结果。与对照组相比,NAFLD合并糖尿病患者的总变异性时域和频域指数(SDNN,总功率)显著降低。然而,三组之间的LF: HF比值没有差异。与对照组相比,伴有糖尿病的NAFLD和没有糖尿病的II级NAFLD患者的肥胖、血脂和糖代谢相关变量也更高。多因素逐步回归分析显示HRV与总胆固醇、脂肪率呈负相关。结论。NAFLD的级别和糖尿病状态都有助于心血管自主功能的下降,其中糖尿病状态而非NAFLD的级别起关键作用。血脂和肥胖也可能导致心脏自主神经功能障碍。
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引用次数: 20
A Combination of Leucine, Metformin, and Sildenafil Treats Nonalcoholic Fatty Liver Disease and Steatohepatitis in Mice 亮氨酸、二甲双胍和西地那非联合治疗小鼠非酒精性脂肪肝和脂肪性肝炎
IF 1.8 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2016-11-30 DOI: 10.1155/2016/9185987
Antje Bruckbauer, J. Banerjee, Lizhi Fu, Fenfen Li, Q. Cao, Xin Cui, R. Wu, Hang Shi, B. Xue, M. Zemel
Sirt1, AMPK, and eNOS modulate hepatic energy metabolism and inflammation and are key players in the development of NASH. L-leucine, an allosteric Sirt1 activator, synergizes with low doses of metformin or sildenafil on the AMPK-eNOS-Sirt1 pathway to reverse mild NAFLD in preclinical mouse models. Here we tested a possible multicomponent synergy to yield greater therapeutic efficacy in NAFLD/NASH. Liver cells and macrophages or an atherogenic diet induced NASH mouse model was treated with two-way and three-way combinations. The three-way combination Sild-Met-Leu increased hepatic fatty acid oxidation and reduced lipogenic gene expression and inflammatory marker in vitro. In mice, Sild-Met-Leu reduced the diet induced increases of ALT, TGFβ, PAI-1, IL1β, and TNFα, hepatic collagen expression, and nearly completely reversed hepatocyte ballooning and triglyceride accumulation, while all two-way combinations had only modest effects. Therefore, these data provide preclinical evidence for therapeutic efficacy of Sild-Met-Leu in the treatment of NAFLD and NASH.
Sirt1, AMPK和eNOS调节肝脏能量代谢和炎症,是NASH发展的关键参与者。l -亮氨酸是一种变抗性Sirt1激活剂,与低剂量二甲双胍或西地那非协同作用于AMPK-eNOS-Sirt1通路,在临床前小鼠模型中逆转轻度NAFLD。在这里,我们测试了一种可能的多组分协同作用,以产生更大的治疗NAFLD/NASH的疗效。肝细胞和巨噬细胞或致动脉粥样硬化性饮食诱导的NASH小鼠模型采用双向和三向联合治疗。三联药增加了肝脏脂肪酸氧化,降低了脂质基因表达和炎症标志物。在小鼠中,Sild-Met-Leu降低了饮食诱导的ALT、TGFβ、PAI-1、il -1 β和TNFα、肝胶原表达的增加,几乎完全逆转了肝细胞膨胀和甘油三酯积累,而所有双向联合治疗的效果都很有限。因此,这些数据为Sild-Met-Leu治疗NAFLD和NASH的疗效提供了临床前证据。
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引用次数: 23
Hyperammonemia Is Associated with Increasing Severity of Both Liver Cirrhosis and Hepatic Encephalopathy 高氨血症与肝硬化和肝性脑病加重有关
IF 1.8 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2016-10-25 DOI: 10.1155/2016/6741754
Abidullah Khan, M. Ayub, Wazir Mohammad Khan
Background. Hyperammonemia resulting from chronic liver disease (CLD) can potentially challenge and damage any organ system of the body, particularly the brain. However, there is still some controversy regarding the diagnostic or prognostic values of serum ammonia in patients with over hepatic encephalopathy, especially in the setting of acute-on-chronic or chronic liver failure. Moreover, the association of serum ammonia with worsening Child-Pugh grade of liver cirrhosis has not been studied. Objective. This study was conducted to solve the controversy regarding the association between hyperammonemia and cirrhosis, especially hepatic encephalopathy in chronically failed liver. Material and Methods. In this study, 171 cirrhotic patients had their serum ammonia measured and analyzed by SPSS version 16. Chi-squared test and one-way ANOVA were applied. Results. The study had 110 male and 61 female participants. The mean age of all the participants in years was 42.33 ± 7.60. The mean duration (years) of CLD was 10.15 ± 3.53 while the mean Child-Pugh (CP) score was 8.84 ± 3.30. Chronic viral hepatitis alone was responsible for 71.3% of the cases. Moreover, 86.5% of participants had hepatic encephalopathy (HE). The frequency of hyperammonemia was 67.3%, more frequent in males (N = 81, z-score = 2.4, and P < 0.05) than in females (N = 34, z-score = 2.4, and P < 0.05), and had a statistically significant relationship with increasing CP grade of cirrhosis (χ 2(2) = 27.46, P < 0.001, Phi = 0.40, and P < 0.001). Furthermore, serum ammonia level was higher in patients with hepatic encephalopathy than in those without it; P < 0.001. Conclusion. Hyperammonemia is associated with both increasing Child-Pugh grade of liver cirrhosis and hepatic encephalopathy.
背景。慢性肝病(CLD)引起的高氨血症可以潜在地挑战和损害身体的任何器官系统,特别是大脑。然而,关于血清氨在肝性脑病患者的诊断或预后价值,特别是在急性慢性或慢性肝衰竭的情况下,仍然存在一些争议。此外,血清氨与Child-Pugh肝硬化分级恶化的关系尚未得到研究。目标。本研究旨在解决关于高氨血症与肝硬化,特别是慢性肝功能衰竭患者肝性脑病之间关系的争议。材料和方法。本研究对171例肝硬化患者的血清氨进行了测量,并使用SPSS version 16进行了分析。采用卡方检验和单因素方差分析。结果。这项研究有110名男性和61名女性参与者。所有参与者的平均年龄为42.33±7.60岁。CLD平均病程(年)为10.15±3.53,Child-Pugh (CP)平均评分为8.84±3.30。慢性病毒性肝炎占71.3%。此外,86.5%的参与者患有肝性脑病(HE)。高氨血症发生率为67.3%,男性(N = 81, z-score = 2.4, P < 0.05)高于女性(N = 34, z-score = 2.4, P < 0.05),且与肝硬化CP分级的升高有统计学意义(χ 2(2) = 27.46, P < 0.001, Phi = 0.40, P < 0.001)。肝性脑病患者血清氨水平高于无肝性脑病患者;P < 0.001。结论。高氨血症与肝硬化Child-Pugh分级增加和肝性脑病相关。
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引用次数: 13
The Use of Thrombopoietin Receptor Agonists for Correction of Thrombocytopenia prior to Elective Procedures in Chronic Liver Diseases: Review of Current Evidence 慢性肝病选择性手术前使用血小板生成素受体激动剂纠正血小板减少症:当前证据综述
IF 1.8 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2016-10-09 DOI: 10.1155/2016/1802932
K. Qureshi, Shyam Patel, A. Meillier
Patients with chronic liver diseases (CLD) undergo a range of invasive procedures during their clinical lifetime. Various hemostatic abnormalities are frequently identified during the periprocedural work-up; including thrombocytopenia. Thrombocytopenia of cirrhosis is multifactorial in origin, and decreased activity of thrombopoietin has been identified to be a major cause. Liver is an important site of thrombopoietin production and its levels are decreased in patients with cirrhosis. Severe thrombocytopenia (platelet counts < 60–75,000/µL) is associated with increased risk of bleeding with invasive procedures. In recent years, compounds with thrombopoietin receptor agonist activity have been studied as therapeutic options to raise platelet counts in CLD. We reviewed the use of Eltrombopag, Romiplostim, and Avatrombopag prior to various invasive procedures in patients with CLD. These agents seem promising in raising platelet counts before elective procedures resulting in reduction in platelet transfusions, and they also enabled more patients to undergo the procedures. However, these studies were not primarily aimed at comparing bleeding episodes among groups. Use of these agents had some adverse consequences, importantly being the occurrence of portal vein thrombosis. This review highlights the need of further studies to identify reliable methods of safely reducing the provoked bleeding risk linked to thrombocytopenia in CLD.
慢性肝病(CLD)患者在其临床生命周期中经历一系列侵入性手术。在围手术期检查中经常发现各种止血异常;包括血小板减少。肝硬化的血小板减少是多因素的,血小板生成素活性降低已被确定为一个主要原因。肝脏是产生血小板生成素的重要部位,肝硬化患者的血小板生成素水平下降。严重的血小板减少症(血小板计数< 60 - 75000 /µL)与有创手术出血风险增加相关。近年来,具有血小板生成素受体激动剂活性的化合物已被研究作为提高CLD血小板计数的治疗选择。我们回顾了在CLD患者进行各种侵入性手术之前使用依曲巴、罗米普罗斯汀和阿伐巴的情况。这些药物似乎有希望在选择性手术前提高血小板计数,从而减少血小板输注,并且它们也使更多的患者接受手术。然而,这些研究的主要目的不是比较各组之间的出血事件。使用这些药物有一些不良后果,主要是门静脉血栓的发生。这篇综述强调了进一步研究的必要性,以确定安全降低CLD中血小板减少相关诱发性出血风险的可靠方法。
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引用次数: 27
Therapeutic Potential of HGF-Expressing Human Umbilical Cord Mesenchymal Stem Cells in Mice with Acute Liver Failure 表达hgf的人脐带间充质干细胞对急性肝衰竭小鼠的治疗潜力
IF 1.8 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2016-02-28 DOI: 10.1155/2016/5452487
Yunxia Tang, Qiongshu Li, Fanwei Meng, Xingyu Huang, Chan Li, Xin Zhou, Xiaoping Zeng, Yixin He, Jia Liu, Xiang Hu, Ji-fan Hu, Tao Li
Human umbilical cord-derived mesenchymal stem cells (UCMSCs) are particularly attractive cells for cellular and gene therapy in acute liver failure (ALF). However, the efficacy of this cell therapy in animal studies needs to be significantly improved before it can be translated into clinics. In this study, we investigated the therapeutic potential of UCMSCs that overexpress hepatocyte growth factor (HGF) in an acetaminophen-induced acute liver failure mouse model. We found that the HGF-UCMSC cell therapy protected animals from acute liver failure by reducing liver damage and prolonging animal survival. The therapeutic effect of HGF-UCMSCs was associated with the increment in serum glutathione (GSH) and hepatic enzymes that maintain redox homeostasis, including γ-glutamylcysteine synthetase (γ-GCS), superoxide dismutase (SOD), and catalase (CAT). Immunohistochemical staining confirmed that HGF-UCMSCs were mobilized to the injured areas of the liver. Additionally, HGF-UCMSCs modulated apoptosis by upregulating the antiapoptotic Bcl2 and downregulating proapoptotic genes, including Bax and TNFα. Taken together, these data suggest that ectopic expression of HGF in UCMSCs protects animals from acetaminophen-induced acute liver failure through antiapoptosis and antioxidation mechanisms.
人脐带源性间充质干细胞(UCMSCs)是急性肝衰竭(ALF)的细胞和基因治疗中特别有吸引力的细胞。然而,这种细胞疗法在动物研究中的疗效需要显著提高,才能转化为临床。在这项研究中,我们研究了过度表达肝细胞生长因子(HGF)的UCMSCs在对乙酰氨基酚诱导的急性肝衰竭小鼠模型中的治疗潜力。我们发现HGF-UCMSC细胞治疗通过减少肝损伤和延长动物生存期来保护动物免受急性肝衰竭。HGF-UCMSCs的治疗效果与血清谷胱甘肽(GSH)和维持氧化还原稳态的肝酶的增加有关,包括γ-谷氨酰半胱氨酸合成酶(γ-GCS)、超氧化物歧化酶(SOD)和过氧化氢酶(CAT)。免疫组织化学染色证实HGF-UCMSCs被动员到肝脏损伤区域。此外,HGF-UCMSCs通过上调抗凋亡基因Bcl2和下调促凋亡基因Bax和TNFα来调节细胞凋亡。综上所述,这些数据表明,HGF在UCMSCs中的异位表达通过抗凋亡和抗氧化机制保护动物免受对乙酰氨基酚诱导的急性肝衰竭。
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引用次数: 26
Elbasvir/Grazoprevir: A Review of the Latest Agent in the Fight against Hepatitis C. Elbasvir/Grazoprevir:抗丙型肝炎最新药物综述
IF 1.8 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2016-01-01 Epub Date: 2016-06-15 DOI: 10.1155/2016/3852126
Allison M Bell, Jamie L Wagner, Katie E Barber, Kayla R Stover

Hepatitis C virus (HCV) is estimated to affect up to 150 million people worldwide. Despite worldwide prevalence, treatment modalities prior to 2011 remained suboptimal, with low virologic response rates and intolerable side effect profiles. Fortunately, the landscape of treatment for chronic hepatitis C has rapidly evolved since the introduction of HCV NS3/4 protease inhibitors in 2011. Elbasvir, a NS5A inhibitor, combined with grazoprevir, a NS3/4A protease inhibitor, is the latest FDA-approved therapy for patients with genotype 1 or 4 chronic hepatitis C, with or without compensated cirrhosis. This review will focus on the current literature and clinical evidence supporting elbasvir/grazoprevir as first-line therapy in patients with genotypes 1 and 4 chronic hepatitis C.

据估计,全世界有1.5亿人感染丙型肝炎病毒(HCV)。尽管在世界范围内流行,但2011年之前的治疗方式仍然不理想,病毒学反应率低,副作用难以忍受。幸运的是,自2011年引入HCV NS3/4蛋白酶抑制剂以来,慢性丙型肝炎的治疗前景迅速发展。Elbasvir(一种NS5A抑制剂)联合grazoprevir(一种NS3/4A蛋白酶抑制剂)是fda批准的最新治疗1型或4型慢性丙型肝炎伴或不伴代偿性肝硬化患者的药物。本综述将重点关注目前支持elbasvir/grazoprevir作为1型和4型慢性丙型肝炎患者一线治疗的文献和临床证据。
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引用次数: 33
The Effect of Artichoke Leaf Extract on Alanine Aminotransferase and Aspartate Aminotransferase in the Patients with Nonalcoholic Steatohepatitis. 朝鲜蓟叶提取物对非酒精性脂肪性肝炎患者丙氨酸氨基转移酶和天冬氨酸氨基转移酶的影响
IF 1.8 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2016-01-01 Epub Date: 2016-05-11 DOI: 10.1155/2016/4030476
Vajiheh Rangboo, Mostafa Noroozi, Roza Zavoshy, Seyed Amirmansoor Rezadoost, Asghar Mohammadpoorasl

Background. Based on recent basic and clinical investigations, the extract of artichoke (Cynara scolymus) leaf has been revealed to be used for hepatoprotective and cholesterol reducing purposes. We aimed to assess the therapeutic effects of artichoke on biochemical and liver biomarkers in patients with nonalcoholic steatohepatitis (NASH). Methods. In a randomized double blind clinical trial, 60 consecutive patients suffering NASH were randomly assigned to receive Cynara scolymus extract (as 6 tablets per day consisting of 2700 mg extract of the herb) as the intervention group or placebo as the control group for two months. Results. Comparing changes in study markers following interventions showed improvement in liver enzymes. The levels of triglycerides and cholesterol were significantly reduced in the group treated with Cynara scolymus when compared to placebo group. To compare the role of Cynara scolymus use with placebo in changes in study parameters, multivariate linear regression models were employed indicating higher improvement in liver enzymes and also lipid profile particularly triglycerides and total cholesterol following administration of Cynara scolymus in comparison with placebo use. Conclusion. This study sheds light on the potential hepatoprotective activity and hypolipidemic effect of Cynara scolymus in management of NASH. This clinical trial is registered in the IRCT, Iranian Registry of Clinical Trials, by number IRCT2014070218321N1.

背景。根据最近的基础和临床研究,发现朝鲜蓟(Cynara scolymus)叶提取物具有保肝和降低胆固醇的作用。我们旨在评估朝鲜蓟对非酒精性脂肪性肝炎(NASH)患者的生化指标和肝脏生物标志物的治疗效果。方法:随机双盲临床试验在一项随机双盲临床试验中,连续 60 名 NASH 患者被随机分配到干预组(每天 6 片,含 2700 毫克草药提取物)或安慰剂对照组(为期两个月)。研究结果比较干预后研究指标的变化显示,肝酶有所改善。与安慰剂组相比,接受仙人掌治疗组的甘油三酯和胆固醇水平明显降低。为了比较仙人掌与安慰剂在研究参数变化中的作用,我们采用了多变量线性回归模型,结果显示,与使用安慰剂相比,服用仙人掌后肝酶和血脂,特别是甘油三酯和总胆固醇的改善程度更高。结论这项研究揭示了仙鹤草在治疗 NASH 方面潜在的保肝活性和降脂作用。该临床试验已在伊朗临床试验注册中心(IRCT)注册,编号为 IRCT2014070218321N1。
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引用次数: 0
Prognostication of Learning Curve on Surgical Management of Vasculobiliary Injuries after Cholecystectomy. 胆囊切除术后血管损伤手术治疗学习曲线的预测。
IF 1.8 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2016-01-01 Epub Date: 2016-07-20 DOI: 10.1155/2016/2647130
Abu Bakar Hafeez Bhatti, Faisal Saud Dar, Haseeb Zia, Muhammad Salman Rafique, Nusrat Yar Khan, Mohammad Salih, Najmul Hassan Shah

Background. Concomitant vascular injury might adversely impact outcomes after iatrogenic bile duct injury (IBDI). Whether a new HPB center should embark upon repair of complex biliary injuries with associated vascular injuries during learning curve is unknown. The objective of this study was to determine outcome of surgical management of IBDI with and without vascular injuries in a new HPB center during its learning curve. Methods. We retrospectively reviewed patients who underwent surgical management of IBDI at our center. A total of 39 patients were included. Patients without (Group 1) and with vascular injuries (Group 2) were compared. Outcome was defined as 90-day morbidity and mortality. Results. Median age was 39 (20-80) years. There were 10 (25.6%) vascular injuries. E2 injuries were associated significantly with high frequency of vascular injuries (66% versus 15.1%) (P = 0.01). Right hepatectomy was performed in three patients. Out of these, two had a right hepatic duct stricture and one patient had combined right arterial and portal venous injury. The number of patients who developed postoperative complications was not significantly different between the two groups (11.1% versus 23.4%) (P = 0.6). Conclusion. Learning curve is not a negative prognostic variable in the surgical management of iatrogenic vasculobiliary injuries after cholecystectomy.

背景。合并血管损伤可能对医源性胆管损伤(IBDI)后的预后产生不利影响。一个新的HPB中心是否应该在学习曲线中着手修复复杂的胆道损伤和相关的血管损伤是未知的。本研究的目的是确定一个新的HPB中心在其学习曲线期间有和没有血管损伤的IBDI手术治疗的结果。方法。我们回顾性地回顾了在本中心接受手术治疗的IBDI患者。共纳入39例患者。无血管损伤组(1组)与血管损伤组(2组)进行比较。结果定义为90天的发病率和死亡率。结果。中位年龄39岁(20-80岁)。血管损伤10例(25.6%)。E2损伤与高血管性损伤发生率显著相关(66%比15.1%)(P = 0.01)。3例患者行右肝切除术。其中2例为右肝管狭窄,1例为右动脉和门静脉合并损伤。两组术后并发症发生率无显著差异(11.1% vs 23.4%) (P = 0.6)。结论。在胆囊切除术后医源性血管损伤的外科治疗中,学习曲线并不是一个负面的预后变量。
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引用次数: 5
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International Journal of Hepatology
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