Health Information Science and Systems最新文献

Objective: To investigate the case of a child infected with coronavirus disease 2019 (COVID-19) who had subsequent viral reactivation.

Methods: We retrospectively analyzed the clinical manifestations, epidemiological data, laboratory and imaging examinations, treatment, and follow-up of the child. And then, we searched related literature using PubMed.

Results: The 9-year-old boy was exposed to COVID-19 in Malawi and tested positive for NAT in Haikou, China. He was asymptomatic and admitted to our hospital. After six negative NATs, he was discharged from the hospital and quarantined in a hotel. His infection was reactivated again after 22 days (interval between first and last positive NATs). The cycle threshold (Ct) values of positive tests were 25 and 31, and the gene sequencing viral loads were very low. The viral strain Kenya/P2601/2020, a variant of the hCoV-19/Wuhan/IVDC-HB-01/2019 genome (GISAID accession IL: EPI_ISL_402119), was found when polymerase chain reaction enrichment was used to sequence the virus. However, people around him tested negative for COVID-19.

Conclusion: First, we confirmed the reactivation of COVID-19 in a child. The risk of recurrent infection with SARS-CoV-2 was low, and the policy of strictly isolating patients carrying long-term viral ribonucleic acid should be reconsidered. The interval positivity was most likely due to incorrect sampling and/or testing methods. SGS and aB testing are recommended for children with viral reactivation. Second, SARS-CoV-2 viral reactivation cannot be ruled out. The possible mechanisms, such as prolonged infection and viral latent reactivation, need further investigation.

Melanoma is a type of skin lesion that is less common than other types of skin lesions, but it is fast growing and spreading. Therefore, it is classified as a serious disease that directly threatens human health and life. Recently, the number of deaths due to this disease has increased significantly. Thus, researchers are interested in creating computer-aided diagnostic systems that aid in the proper diagnosis and detection of these lesions from dermoscopy images. Relying on manual diagnosis is time consuming in addition to requiring enough experience from dermatologists. Current skin lesion segmentation systems use deep convolutional neural networks to detect skin lesions from RGB dermoscopy images. However, relying on RGB color model is not always the optimal choice to train such networks because some fine details of lesion parts in the dermoscopy images can not clearly appear using RGB color model. Other color models exhibit invariant features of the dermoscopy images so that they can improve the performance of deep neural networks. In the proposed Color Invariant U-Net (CIU-Net) model, a color mixture block is added at the beginning of the contracting path of U-Net. The color mixture block acts as a mixer to learn the fusion of various input color models and create a new one with three channels. Furthermore, a new channel-attention module is included in the connection path between encoder and decoder paths. This channel attention module is developed to enrich the extracted color features. From the experimental result, we found that the proposed CIU-Net works in harmony with the new proposed hybrid loss function to enhance skin segmentation results. The performance of the proposed CIU-Net architecture is evaluated using ISIC 2018 dataset and the results are compared with other recent approaches. Our proposed method outperformed other recent approaches and achieved the best Dice and Jaccard coefficient with values 92.56% and 91.40%, respectively.

Electroencephalogram (EEG) microstates provide powerful tools for identifying EEG features due to their rich temporal information. In this study, we tested whether microstates can measure the severity of Alzheimer's disease (AD) and mild cognitive impairment (MCI) in patients and effectively distinguish AD from MCI. We defined two features using transition probabilities (TPs), and one was used to evaluate between-group differences in microstate parameters to assess the within-group consistency of TPs and MMSE scores. Another feature was used to distinguish AD from MCI in machine learning models. Tests showed that there were between-group differences in the temporal characteristics of microstates, and some kinds of TPs were significantly correlated with MMSE scores within groups. Based on our newly defined time-factor transition probabilities (TTPs) feature and partial accumulation strategy, we obtained promising scores for accuracy, sensitivity, and specificity of 0.938, 0.923, and 0.947, respectively. These results provide evidence for microstates as a neurobiological marker of AD.

With the development of the Internet, more and more people prefer to confide their sentiments in the virtual world, especially those with depression. The social media where people with depression collectively leave messages is called the "Tree Hole". The purpose of this article is to support the "Tree Hole" rescue volunteers to help patients with depression, especially after the outbreak of COVID-19 and other major events, to guide the crisis intervention of patients with depression. Based on the message data of "Tree Hole" named "Zou Fan", this paper used a deep learning model and sentiment scoring algorithm to analyze the fluctuation characteristics sentiment of user's message in different time dimensions. Through detailed investigation of the research results, we found that the number of "Tree Hole" messages in multiple time dimensions is positively correlated to emotion. The longer the "Tree Hole" is formed, the more negative the emotion is, and the outbreak of COVID-19 and other major events have obvious effects on the emotion of the messages. In order to improve the efficiency of "Tree Hole" rescue, volunteers should focus on the long-formed "Tree Hole" and the user groups that are active in the early morning. This research is of great significance for the emotional guidance of online mental health patients, especially the crisis intervention for depression patients after the outbreak of COVID-19 and other major events.

Introduction: Reliable computer diagnosis of diabetic retinopathy (DR) is needed to rescue many with diabetes who may be under threat of blindness. This research aims to detect the presence of diabetic retinopathy in fundus images and grade the disease severity without lesion segmentation.

Methods: To ensure that the fundus images are in a standard state of brightness, a series of preprocessing steps have been applied to the green channel image using histogram matching and a median filter. Then, contrast-limited adaptive histogram equalisation is performed, followed by the unsharp filter. The preprocessed image is divided into small blocks, and then each block is processed to extract uniform local binary patterns (LBPs) features. The extracted features are encoded, and the feature size is reduced to 3.5 percent of its original size. Classifiers like Support Vector Machine (SVM) and a proposed CNN model were used to classify retinal fundus images. The classification is abnormal or normal and to grade the severity of DR.

Results: Our feature extraction method was tested on a binary classifier and resulted in an accuracy of 98.37% and 98.84% on the Messidor2 and EyePACS databases, respectively. The proposed system could grade DR severity into three grades (0: no DR, 1: mild DR, and 5: moderate, severe NPDR, and PDR). It obtains an F1-score of 0.9617 and an accuracy of 95.37% on the EyePACS database, and an F1-score of 0.9860 and an accuracy of 97.57% on the Messidor2 database. The resultant values are dependent on the selection of (neighbours, radius) pairs during the extraction of LBP features.

Conclusions: This study's results proved that the preprocessing steps are significant and had a great effect on highlighting image features. The novel method of stacking and encoding the LBP values in the feature vector greatly affects results when using SVM or CNN for classification. The proposed system outperforms the state of the artwork. The proposed CNN model performs better than SVM.

We aimed to assess different machine learning techniques for predicting infant mortality (<1 year) in Bangladesh. The decision tree (DT), random forest (RF), support vector machine (SVM) and logistic regression (LR) approaches were evaluated through accuracy, sensitivity, specificity, precision, F1-score, receiver operating characteristics curve and k-fold cross-validation via simulations. The Boruta algorithm and chi-square ( ${\chi }^2$ ) test were used for features selection of infant mortality. Overall, the RF technique (Boruta: accuracy = 0.8890, sensitivity = 0.0480, specificity = 0.9789, precision = 0.1960, F1-score = 0.0771, AUC = 0.6590; ${\chi }^2$ : accuracy = 0.8856, sensitivity = 0.0536, specificity = 0.9745, precision = 0.1837, F1-score = 0.0828, AUC = 0.6480) showed higher predictive performance for infant mortality compared to other approaches. Age at first marriage and birth, body mass index (BMI), birth interval, place of residence, religion, administrative division, parents education, occupation of mother, media-exposure, wealth index, gender of child, birth order, children ever born, toilet facility and cooking fuel were potential determinants of infant mortality in Bangladesh. Study findings may help women, stakeholders and policy-makers to take necessary steps for reducing infant mortality by creating awareness, expanding educational programs at community levels and public health interventions.

Over the past few decades, health care industries and medical practitioners faced a lot of obstacles to diagnosing medical-related problems due to inadequate technology and availability of equipment. In the present era, computer science technologies such as IoT, Cloud Computing, Artificial Intelligence and its allied techniques, etc. play a crucial role in the identification of medical diseases, especially in the domain of Ophthalmology. Despite this, ophthalmologists have to perform the various disease diagnosis task manually which is time-consuming and the chances of error are also very high because some of the abnormalities of eye diseases possess the same symptoms. Furthermore, multiple autonomous systems also exist to categorize the diseases but their prediction rate does not accomplish state-of-art accuracy. In the proposed approach by implementing the concept of Attention, Transfer Learning with the Deep Convolution Neural Network, the model accomplished an accuracy of 97.79% and 95.6% on the training and testing data respectively. This autonomous model efficiently classifies the various oscular disorders namely Choroidal Neovascularization, Diabetic Macular Edema, Drusen from the Optical Coherence Tomography images. It may provide a realistic solution to the healthcare sector to bring down the ophthalmologist burden in the screening of Diabetic Retinopathy.

Knowledge of muscle forces' contributions to the joint contact forces can assist in the evaluation of muscle function, joint injury prevention, treatment of gait disorders, and arthroplasty planning. This study's objective was to evaluate the contributions of human lower limb muscles to the hip, knee, and ankle joint contact forces during the stance phase of running. A total of 25 muscles (or groups) were investigated based on the OpenSim framework along the anterior-posterior, superoinferior, and mediolateral components of each joint coordinate system. It was revealed that, during the running stance phase, the gluteus medius, gluteus maximus, and iliopsoas mainly contributed to the hip contact force. The soleus, vastus group, and rectus femoris primarily contributed to the knee contact force, while the peroneus, soleus, gluteus medius, and gastrocnemius mainly contributed to the ankle joint force; some muscles simultaneously offloaded the joints during the stance phase. The distributive pattern of the individual muscle functions contributing to the joint load may substantially differ during the running and walking stance phases. This study's findings may further provide suggestive information for the design of lower limb joint prosthesis, the study of the biomechanics of pathologic walking and running, and the progression of joint osteoarthritis.

We offer a framework for automatically and accurately segmenting breast lesions from Dynamic Contrast Enhanced (DCE) MRI in this paper. The framework is built using max flow and min cut problems in the continuous domain over phase preserved denoised images. Three stages are required to complete the proposed approach. First, post-contrast and pre-contrast images are subtracted, followed by image registrations that benefit to enhancing lesion areas. Second, a phase preserved denoising and pixel-wise adaptive Wiener filtering technique is used, followed by max flow and min cut problems in a continuous domain. A denoising mechanism clears the noise in the images by preserving useful and detailed features such as edges. Then, lesion detection is performed using continuous max flow. Finally, a morphological operation is used as a post-processing step to further delineate the obtained results. A series of qualitative and quantitative trials employing nine performance metrics on 21 cases with two different MR image resolutions were used to verify the effectiveness of the proposed method. Performance results demonstrate the quality of segmentation obtained from the proposed method.

Purpose: Vascular age (VA) is the direct index to reflect vascular aging, so it plays a particular role in public health. How to obtain VA conveniently and cheaply has always been a research hotspot. This study proposes a new method to evaluate VA with wrist pulse signal.

Methods: Firstly, we fit the pulse signal by mixed Gaussian model (MGM) to extract the shape features, and adopt principal component analysis (PCA) to optimize the dimension of the shape features. Secondly, the principal components and chronological age (CA) are respectively taken as the independent variables and dependent variable to establish support vector regression (SVR) model. Thirdly, the principal components are fed into the SVR model to predicted the vascular aging of each subject. The predicted value is regarded as the description of VA. Finally, we compare the correlation coefficients of VA with pulse width (PW), inflection point area ratio (IPA), Ratio b/a (RBA), augmentation index (AIx), diastolic augmentation index (DAI) and pulse transit time (PTT) with those of CA with these six indices.

Results: Compared with the CA, the VA is closer to PW (r = 0.539, P < 0.001 to r = 0.589, P < 0.001 in men; r = 0.325, P < 0.001 to r = 0.400, P < 0.001 in women), IPA (r =  - 0.446, P < 0.001 to r =  - 0.534, P < 0.001 in men; r =  - 0.623, P < 0.001 to r =  - 0.660, P < 0.001 in women), RBA (r = 0.328, P < 0.001 to r = 0.371, P < 0.001 in women), AIx (r = 0.659, P < 0.001 to r = 0.738, P < 0.001 in men; r = 0.547, P < 0.001 to r = 0.573, P < 0.001 in women), DAI (r = 0.517, P < 0.001 to r = 0.532, P < 0.001 in men; r = 0.507, P < 0.001 to r = 0.570, P < 0.001 in women) and PTT (r = 0.526, P < 0.001 to r = 0.659, P < 0.001 in men; r = 0.577, P < 0.001 to r = 0.814, P < 0.001 in women).

Conclusion: The VA is more representative of vascular aging than CA. The method presented in this study provides a new way to directly and objectively assess vascular aging in public health.