Endobronchial inflammatory polyps are one of the rarest benign bronchial tumors. Tumors of benign etiology are even rare. Inflammatory bronchial polyps are frequently solitary although rarely can be multifocal. We are presenting a rare case of multiple endobronchial inflammatory polyps presenting as pneumonia.
{"title":"Endobronchial inflammatory polyps: A rare clinical entity","authors":"Sharad Joshi, Nitesh Tayal, Rajesh Gupta, Ankit Bhatia","doi":"10.4103/ecdt.ecdt_60_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_60_22","url":null,"abstract":"Endobronchial inflammatory polyps are one of the rarest benign bronchial tumors. Tumors of benign etiology are even rare. Inflammatory bronchial polyps are frequently solitary although rarely can be multifocal. We are presenting a rare case of multiple endobronchial inflammatory polyps presenting as pneumonia.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"36 1","pages":"134 - 137"},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80951157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zeinab M. Zaki, Magdy Khalil, K. Wagih, H. Ezzelregal
Context After description of the new first case of AIDS in 1981, the HIV pandemic expanded very rapidly to become a great global public health problem with wide health, economic, social, and developmental consequences that have not been seen with any other disease. Globally, there have been gains across the HIV testing and treatment cascade. The greatest contributor to the illness and deaths in persons infected with HIV is pulmonary disease. Aims The aim was to study the pattern of respiratory manifestations in HIV-infected patients among a sample of Egyptians. Settings and design A prospective, observational study. Patients and methods This study recruited 121 HIV patients with respiratory system involvement admitted to Abbassia Fever Hospital or Abbassia Chest Hospitals between December 2017 and March 2020. Clinical assessment included demographic data, history of chest symptoms, and comorbidities and local and general examination. Chest imaging was requested/reviewed, and procedures were performed as required. Laboratory assessment included CD4 count, and microbiological examinations of sputum and pleural fluid if found. Statistical analysis used SPSS program (Statistical Package for the Social Sciences) software, version 18.0. Results Of the participants 62 % have been receiving or previously received antiretroviral treatment. Cough was the most frequent symptom in 91.7%. Pleural collection was the most frequent radiological finding on chest radiology in 23% of patients. Tuberculosis was commonly a concomitant infection in 29.7% of patients. CD4 count ranged from 16 to 450 cells/mm3. The diagnosis of PJP and multidrug resistance tuberculosis was highly significantly associated with low CD4 count (P<0.01). Conclusion HIV infection is associated with a wide range of respiratory manifestations with infectious complications representing the majority of them. Low CD4 count, receiving antiretroviral treatment, and the source of HIV infection (sexual or intravenous drug abuse) are documented as risk factors for respiratory involvement in HIV patients.
在1981年描述了新的第一例艾滋病病例之后，艾滋病毒流行病迅速蔓延，成为一个重大的全球公共卫生问题，具有广泛的健康、经济、社会和发展后果，这是任何其他疾病都没有看到的。在全球范围内，艾滋病毒检测和治疗都取得了进展。导致艾滋病毒感染者患病和死亡的最大因素是肺病。目的是研究埃及人样本中艾滋病毒感染患者的呼吸道表现模式。背景与设计前瞻性观察性研究。患者和方法本研究招募了2017年12月至2020年3月期间在阿巴西亚发热医院或阿巴西亚胸科医院住院的121例呼吸系统受累的HIV患者。临床评估包括人口统计资料、胸部症状史、合并症以及局部和全身检查。要求/复查胸部成像，并按要求进行手术。实验室评估包括CD4计数和痰液和胸膜液微生物学检查(如发现)。统计分析使用SPSS (Statistical Package for Social Sciences)软件，版本18.0。结果62%的参与者正在接受或以前接受过抗逆转录病毒治疗。咳嗽是最常见的症状，占91.7%。23%的患者胸膜收集是最常见的放射学发现。29.7%的患者伴有结核病。CD4计数范围从16到450个细胞/mm3。CD4计数低与PJP和耐多药结核病的诊断高度相关(P<0.01)。结论HIV感染与多种呼吸道症状相关，其中感染性并发症占多数。CD4计数低、接受抗逆转录病毒治疗和艾滋病毒感染来源(性行为或静脉药物滥用)是艾滋病毒患者呼吸系统受累的危险因素。
{"title":"HIV-related pulmonary manifestations among egyptian patients","authors":"Zeinab M. Zaki, Magdy Khalil, K. Wagih, H. Ezzelregal","doi":"10.4103/ecdt.ecdt_45_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_45_22","url":null,"abstract":"Context After description of the new first case of AIDS in 1981, the HIV pandemic expanded very rapidly to become a great global public health problem with wide health, economic, social, and developmental consequences that have not been seen with any other disease. Globally, there have been gains across the HIV testing and treatment cascade. The greatest contributor to the illness and deaths in persons infected with HIV is pulmonary disease. Aims The aim was to study the pattern of respiratory manifestations in HIV-infected patients among a sample of Egyptians. Settings and design A prospective, observational study. Patients and methods This study recruited 121 HIV patients with respiratory system involvement admitted to Abbassia Fever Hospital or Abbassia Chest Hospitals between December 2017 and March 2020. Clinical assessment included demographic data, history of chest symptoms, and comorbidities and local and general examination. Chest imaging was requested/reviewed, and procedures were performed as required. Laboratory assessment included CD4 count, and microbiological examinations of sputum and pleural fluid if found. Statistical analysis used SPSS program (Statistical Package for the Social Sciences) software, version 18.0. Results Of the participants 62 % have been receiving or previously received antiretroviral treatment. Cough was the most frequent symptom in 91.7%. Pleural collection was the most frequent radiological finding on chest radiology in 23% of patients. Tuberculosis was commonly a concomitant infection in 29.7% of patients. CD4 count ranged from 16 to 450 cells/mm3. The diagnosis of PJP and multidrug resistance tuberculosis was highly significantly associated with low CD4 count (P<0.01). Conclusion HIV infection is associated with a wide range of respiratory manifestations with infectious complications representing the majority of them. Low CD4 count, receiving antiretroviral treatment, and the source of HIV infection (sexual or intravenous drug abuse) are documented as risk factors for respiratory involvement in HIV patients.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"48 1","pages":"120 - 129"},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75256692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashraf Abdeen, Lamiaa Shaaban, Safaa A Mahran, Shereen Farghaly, Hend M Saleh
Abstract Background To compare the effectiveness of ES and TS plus exercise breathing after discharge on mechanically ventilated patients with chronic obstructive pulmonary disease (COPD) to those receiving standard care in terms of 30-day mortality, hospital readmission, and health-related quality of life (HRQOL). Patients and methods The current study was a randomized controlled trial. It included 108 newly admitted patients with COPD to RICU, Chest Department, Assiut University Hospital, Egypt, between June 2018 and May 2020. They were divided into two groups: group I received the usual care plus ES and TS plus breathing exercise, and group II received the usual care alone. Thirty-day mortality, hospital readmission, and HRQOL assessed by MFR-28 were recorded and evaluated. Student t test, Mann–Whitney U test, χ 2 test, and Fisher exact test were performed to analyze the data. Results A total of 108 patients with COPD were included. Early rehabilitation program (ES and TS) plus exercise breathing for patients with COPD in the ICU showed decreased 30-day mortality, decreased hospital readmission, and improved HRQOL as compared with patients with COPD who received usual care. Conclusion Patients with COPD who were treated with an early rehabilitation program (ES and TS) combined with exercise breathing had a better prognosis and a higher QOL. Clinical trial.gov The study was registered under NCT03253380.
{"title":"A randomized trial comparing the effects of electrical stimulation of the quadriceps muscle and decreased trigger sensitivity plus exercise breathing after discharge on mechanically ventilated patients with chronic obstructive pulmonary disease to those receiving standard care in terms of 30-day mortality, hospital readmission, and health-related quality of life","authors":"Ashraf Abdeen, Lamiaa Shaaban, Safaa A Mahran, Shereen Farghaly, Hend M Saleh","doi":"10.4103/ecdt.ecdt_33_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_33_22","url":null,"abstract":"Abstract Background To compare the effectiveness of ES and TS plus exercise breathing after discharge on mechanically ventilated patients with chronic obstructive pulmonary disease (COPD) to those receiving standard care in terms of 30-day mortality, hospital readmission, and health-related quality of life (HRQOL). Patients and methods The current study was a randomized controlled trial. It included 108 newly admitted patients with COPD to RICU, Chest Department, Assiut University Hospital, Egypt, between June 2018 and May 2020. They were divided into two groups: group I received the usual care plus ES and TS plus breathing exercise, and group II received the usual care alone. Thirty-day mortality, hospital readmission, and HRQOL assessed by MFR-28 were recorded and evaluated. Student t test, Mann–Whitney U test, χ 2 test, and Fisher exact test were performed to analyze the data. Results A total of 108 patients with COPD were included. Early rehabilitation program (ES and TS) plus exercise breathing for patients with COPD in the ICU showed decreased 30-day mortality, decreased hospital readmission, and improved HRQOL as compared with patients with COPD who received usual care. Conclusion Patients with COPD who were treated with an early rehabilitation program (ES and TS) combined with exercise breathing had a better prognosis and a higher QOL. Clinical trial.gov The study was registered under NCT03253380.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135667818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Noninvasive ventilation in patients with acute severe asthma: ‘Be Sure, Be vigilant’","authors":"Gopal Chawla, A. Esquinas","doi":"10.4103/ecdt.ecdt_32_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_32_22","url":null,"abstract":"","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"90 1","pages":"130 - 131"},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80295665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Both adults and children experience bronchial asthma, which is the most common chronic respiratory condition. The prevalence of asthma varies widely by geography and age, with its prevalence ranging from 0.2 to 21.0% in adults. However, there are no data on the prevalence of asthma among adults in the Jazan Region, which is located in the southern part of Saudi Arabia. Objective To assess the prevalence of asthma among medical students in Jazan University, Jazan Region of Saudi Arabia. Methods In this cross-sectional study, the prevalence of asthma was determined using a modified and translated International Study of Asthma and Allergies in Childhood questionnaire. Adult students of health-related colleges at Jazan University constituted the target population in the region. Results There were 1210 responders, which included 654 (54.0%) males and 556 (46.0%) females. In total, 761 (62.9%) students (35.3% men) resided in rural areas, whereas 449 (37.1%) students resided in urban areas. Additionally, 20.2% of students experienced life-long wheezing. During the previous 12 months, 218 (18%) and 191 (15.8%) students experienced exercise-induced wheezing and nonexercise-induced wheezing, respectively. Furthermore, 188 (15.5%) students had a medical history of asthma, and the prevalence of asthma did not differ significantly between males and females (P=0.412). A physician confirmed that 13.7% of the participants had asthma. Conclusion Our results demonstrated a high frequency of asthma among the medical students of Jazan University in the Jazan Region. Asthma diagnosis was predicted using an identifiable questionnaire and without using physiological measures and laboratory factors.
{"title":"Asthma prevalence among medical students of jazan university, saudi arabia: A cross-sectional study","authors":"Abdulrahman Hakami, Abuobaida Yassin, Meshal Bajoned, Reem Maashi, Amna Zila, Nuha Dilyh, Samar Dilyh, Fatima Ezzi, Maha Madkhali","doi":"10.4103/ecdt.ecdt_50_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_50_22","url":null,"abstract":"Background Both adults and children experience bronchial asthma, which is the most common chronic respiratory condition. The prevalence of asthma varies widely by geography and age, with its prevalence ranging from 0.2 to 21.0% in adults. However, there are no data on the prevalence of asthma among adults in the Jazan Region, which is located in the southern part of Saudi Arabia. Objective To assess the prevalence of asthma among medical students in Jazan University, Jazan Region of Saudi Arabia. Methods In this cross-sectional study, the prevalence of asthma was determined using a modified and translated International Study of Asthma and Allergies in Childhood questionnaire. Adult students of health-related colleges at Jazan University constituted the target population in the region. Results There were 1210 responders, which included 654 (54.0%) males and 556 (46.0%) females. In total, 761 (62.9%) students (35.3% men) resided in rural areas, whereas 449 (37.1%) students resided in urban areas. Additionally, 20.2% of students experienced life-long wheezing. During the previous 12 months, 218 (18%) and 191 (15.8%) students experienced exercise-induced wheezing and nonexercise-induced wheezing, respectively. Furthermore, 188 (15.5%) students had a medical history of asthma, and the prevalence of asthma did not differ significantly between males and females (P=0.412). A physician confirmed that 13.7% of the participants had asthma. Conclusion Our results demonstrated a high frequency of asthma among the medical students of Jazan University in the Jazan Region. Asthma diagnosis was predicted using an identifiable questionnaire and without using physiological measures and laboratory factors.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"17 1","pages":"25 - 32"},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75003047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamed Shaaban Mousa, Ahmed Mamdooh Ghoname, Dalia Abd El-Kareem Ateya, Hamed A H Abdallah, Salwa Hassan Ahmed
Abstract Objectives Pleural mesothelioma is a rapidly progressing pleural neoplasm caused by asbestos exposure of a long latency around 30-40 years. Patients with mesothelioma are usually diagnosed at a late stage with poor outcomes in terms of morbidity and mortality with 6–12 months’ median survival. Despite the prohibited use of asbestos, malignant pleural mesothelioma is still increasingly being occurred in young age and female patients. Different un-standardized biomarkers have been used to diagnose MPM as mesothelin and febulin with controversial results, so we used CD 24 as a biomarker to diagnose and differentiate between different subtypes of malignant pleural mesothelioma. Materials and methods Our cohort study included total of fifty-nine patients with exudative pleural effusion. All patients underwent full history taking, clinical examination, blood tests (CBC, coagulation profile, liver and kidney functions), tapping of pleural effusion and to send pleural fluid investigations for LDH, albumin, total protein and albumin, then confirmed exudative pleural effusion patients were subjected to thoracic ultrasonography and medical thoracoscopy for the majority of cases or ultrasound guided biopsy in selected cases to obtain pleural biopsies for histopathology and then the examination of pleural biopsies for CD24 expression. Results Our study demonstrated the possibility of using CD24 as a biomarker in the immunostaining of pleural biopsies to differentiate between malignant pleural mesothelioma and pleural malignancy other than mesothelioma (18 mesothelioma cases versus 2 nonmesothelioma malignant cases) with high statistical significance P value < 0.001 and also it can discriminate between subtypes of mesothelioma as it showed marked significance in epithelioid subtype (12 epithelioid versus 1 sarcomatoid versus 5 biphasic subtypes) with more uptake by score +2 in epithelioid mesothelioma. Conclusions CD24 can be supposed to be a routine biomarker for immunohistochemistry of pleural tissue samples in diagnosis of mesothelioma and it can be used to differentiate between subtypes of malignant mesothelioma subtypes.
{"title":"The role of CD24 as a potential biomarker for malignant pleural mesothelioma","authors":"Mohamed Shaaban Mousa, Ahmed Mamdooh Ghoname, Dalia Abd El-Kareem Ateya, Hamed A H Abdallah, Salwa Hassan Ahmed","doi":"10.4103/ecdt.ecdt_11_23","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_11_23","url":null,"abstract":"Abstract Objectives Pleural mesothelioma is a rapidly progressing pleural neoplasm caused by asbestos exposure of a long latency around 30-40 years. Patients with mesothelioma are usually diagnosed at a late stage with poor outcomes in terms of morbidity and mortality with 6–12 months’ median survival. Despite the prohibited use of asbestos, malignant pleural mesothelioma is still increasingly being occurred in young age and female patients. Different un-standardized biomarkers have been used to diagnose MPM as mesothelin and febulin with controversial results, so we used CD 24 as a biomarker to diagnose and differentiate between different subtypes of malignant pleural mesothelioma. Materials and methods Our cohort study included total of fifty-nine patients with exudative pleural effusion. All patients underwent full history taking, clinical examination, blood tests (CBC, coagulation profile, liver and kidney functions), tapping of pleural effusion and to send pleural fluid investigations for LDH, albumin, total protein and albumin, then confirmed exudative pleural effusion patients were subjected to thoracic ultrasonography and medical thoracoscopy for the majority of cases or ultrasound guided biopsy in selected cases to obtain pleural biopsies for histopathology and then the examination of pleural biopsies for CD24 expression. Results Our study demonstrated the possibility of using CD24 as a biomarker in the immunostaining of pleural biopsies to differentiate between malignant pleural mesothelioma and pleural malignancy other than mesothelioma (18 mesothelioma cases versus 2 nonmesothelioma malignant cases) with high statistical significance P value < 0.001 and also it can discriminate between subtypes of mesothelioma as it showed marked significance in epithelioid subtype (12 epithelioid versus 1 sarcomatoid versus 5 biphasic subtypes) with more uptake by score +2 in epithelioid mesothelioma. Conclusions CD24 can be supposed to be a routine biomarker for immunohistochemistry of pleural tissue samples in diagnosis of mesothelioma and it can be used to differentiate between subtypes of malignant mesothelioma subtypes.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135667820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ecdt.ecdt_121_22
Gehan M Elassal, Mahmoud M Mahmoud, Dina E Aly
Abstract Background Known as severe acute respiratory syndrome coronavirus 2, the severe acute respiratory syndrome coronavirus is a new coronavirus illness [coronavirus disease-2019 (COVID-19)], it spreads quickly over the world. Patients with COVID-19 frequently have changes in platelet count. The platelet count is a highly useful clinical tool for tracking patients with aggressive viral infections who have rapidly changing health conditions since it is a sensitive indicator of sickness severity. Aim To study thrombocytopenia as a prognostic factor in COVID-19 patients and its relation with the length of hospital stay and prognosis. Patients and methods A total of 60 COVID-19 patients were involved in the prospective study during the period from June 2020 to December 2020 who were admitted to the isolation hospital, Ain Shams University Hospitals. Then for each patient, complete blood count at admission was done, repeated on day 7, day 14, and day 21. Patients were followed regarding the length of hospital stay and mortality. Results Out of 60 patients, 10 (16.6%) patients were thrombocytopenic. The length of hospital stay was significantly higher in a thrombocytopenic group. There was a high statistically significant difference between the normal platelets count group and the thrombocytopenic groups regarding outcome ( P <0.001). In thrombocytopenic patients, five (50%) showed deterioration, four (40%) patients died and one patient in this group showed complete recovery. Conclusion Thrombocytopenia is associated with increased length of hospital stay and poor prognosis in patients with COVID-19.
{"title":"The effect of thrombocytopenia in coronavirus disease patients in comparison with patients with normal platelet count","authors":"Gehan M Elassal, Mahmoud M Mahmoud, Dina E Aly","doi":"10.4103/ecdt.ecdt_121_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_121_22","url":null,"abstract":"Abstract Background Known as severe acute respiratory syndrome coronavirus 2, the severe acute respiratory syndrome coronavirus is a new coronavirus illness [coronavirus disease-2019 (COVID-19)], it spreads quickly over the world. Patients with COVID-19 frequently have changes in platelet count. The platelet count is a highly useful clinical tool for tracking patients with aggressive viral infections who have rapidly changing health conditions since it is a sensitive indicator of sickness severity. Aim To study thrombocytopenia as a prognostic factor in COVID-19 patients and its relation with the length of hospital stay and prognosis. Patients and methods A total of 60 COVID-19 patients were involved in the prospective study during the period from June 2020 to December 2020 who were admitted to the isolation hospital, Ain Shams University Hospitals. Then for each patient, complete blood count at admission was done, repeated on day 7, day 14, and day 21. Patients were followed regarding the length of hospital stay and mortality. Results Out of 60 patients, 10 (16.6%) patients were thrombocytopenic. The length of hospital stay was significantly higher in a thrombocytopenic group. There was a high statistically significant difference between the normal platelets count group and the thrombocytopenic groups regarding outcome ( P <0.001). In thrombocytopenic patients, five (50%) showed deterioration, four (40%) patients died and one patient in this group showed complete recovery. Conclusion Thrombocytopenia is associated with increased length of hospital stay and poor prognosis in patients with COVID-19.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"2022 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135667830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ecdt.ecdt_129_22
Mohamed A Tageldin, Riham H Raafat, Zeynab Noah
Abstract Background Each component of the original physical function ICU test (PFIT) had little clinical utility. Given the growing body of research on ICU strength and mobility, objective functional evaluations with great clinical usefulness are needed. Scoring the original PFIT improves clinical utility and research to compare ICU patient function and intervention responsiveness. Aim To evaluate the muscle strength and functional condition of ICU patients and link these procedures to the length of stay at Ain Shams University Hospital and outcome. Patients and methods The research included 40 patients who were admitted to the respiratory ICU either mechanically ventilated or not. Results There was high significant decrease in TLC; there was high significant increase in Hb, albumin, K, and Mg according to two assessment points. Most patients had a score of 3 of shoulder strength and knee strength but score 2 regarding Sit to stand assistance. There was high significant increase in PFIT-s in the second assessment. There was substantial enhancement in the second assessment compared with first assessment regarding different score results. Conclusion Based on the finding we conclude that, prolonged immobility during hospitalization results in loss of muscle strength and functional capacity. There was positive correlation between muscular strength and functional status, considering PFIT scales. The longer length of stay in ICU, the greater the loss of functional capacity in critical patients.
{"title":"Physical and functional profile of ICU patients and correlation between functional scales (Physical function in ICU test – scored PFIT)","authors":"Mohamed A Tageldin, Riham H Raafat, Zeynab Noah","doi":"10.4103/ecdt.ecdt_129_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_129_22","url":null,"abstract":"Abstract Background Each component of the original physical function ICU test (PFIT) had little clinical utility. Given the growing body of research on ICU strength and mobility, objective functional evaluations with great clinical usefulness are needed. Scoring the original PFIT improves clinical utility and research to compare ICU patient function and intervention responsiveness. Aim To evaluate the muscle strength and functional condition of ICU patients and link these procedures to the length of stay at Ain Shams University Hospital and outcome. Patients and methods The research included 40 patients who were admitted to the respiratory ICU either mechanically ventilated or not. Results There was high significant decrease in TLC; there was high significant increase in Hb, albumin, K, and Mg according to two assessment points. Most patients had a score of 3 of shoulder strength and knee strength but score 2 regarding Sit to stand assistance. There was high significant increase in PFIT-s in the second assessment. There was substantial enhancement in the second assessment compared with first assessment regarding different score results. Conclusion Based on the finding we conclude that, prolonged immobility during hospitalization results in loss of muscle strength and functional capacity. There was positive correlation between muscular strength and functional status, considering PFIT scales. The longer length of stay in ICU, the greater the loss of functional capacity in critical patients.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135667898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Coronavirus disease 2019 (COVID-19) infection is currently the greatest atypical pneumonia outbreak, causing widespread anxiety and fear. Objectives To study cases with clinical manifestations that have been identified as COVID-19 according to the Egyptian Ministry of Health’s criteria, their management protocol, and outcome data at the isolation department of El-Dakhla General Hospital. Patients and methods This work was performed upon 106 patients with clinical symptoms of COVID-19 at the isolation department of El-Dakhla General Hospital. Results Mortality was associated with older age. No patients within the died group had been vaccinated. Vaccination was significantly associated with decreased severity of chest affection, admission to the ICU, and duration of admission. Mortality was associated with severity of chest affection. All died patients were admitted to the ICU. This study also revealed that abnormal vital and laboratory data were significantly associated with mortality. On using binary regression analysis of factors to be significantly associated with mortality, lower duration of admission and not being admitted to ICU decreased the risk of mortality among the studied patients, yet was statistically nonsignificant (P>0.05), whereas higher C-reactive protein on admission increased the risk by 1.186 folds. Conclusion Age, vaccination state, severity of chest affection, ICU admission and duration, use of some medications, vital data, and laboratory data are important factors to assess the prognosis and severity of COVID infection.
{"title":"Study of coronavirus disease 2019 cases at the isolation department of el-dakhla general hospital","authors":"Mohamed Tageldein, Mahmoud Mohamed, M. Ibrahim","doi":"10.4103/ecdt.ecdt_36_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_36_22","url":null,"abstract":"Background Coronavirus disease 2019 (COVID-19) infection is currently the greatest atypical pneumonia outbreak, causing widespread anxiety and fear. Objectives To study cases with clinical manifestations that have been identified as COVID-19 according to the Egyptian Ministry of Health’s criteria, their management protocol, and outcome data at the isolation department of El-Dakhla General Hospital. Patients and methods This work was performed upon 106 patients with clinical symptoms of COVID-19 at the isolation department of El-Dakhla General Hospital. Results Mortality was associated with older age. No patients within the died group had been vaccinated. Vaccination was significantly associated with decreased severity of chest affection, admission to the ICU, and duration of admission. Mortality was associated with severity of chest affection. All died patients were admitted to the ICU. This study also revealed that abnormal vital and laboratory data were significantly associated with mortality. On using binary regression analysis of factors to be significantly associated with mortality, lower duration of admission and not being admitted to ICU decreased the risk of mortality among the studied patients, yet was statistically nonsignificant (P>0.05), whereas higher C-reactive protein on admission increased the risk by 1.186 folds. Conclusion Age, vaccination state, severity of chest affection, ICU admission and duration, use of some medications, vital data, and laboratory data are important factors to assess the prognosis and severity of COVID infection.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"48 1","pages":"33 - 39"},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76198598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Riham Farouk, Gamal Abdel-latif, Ibrahim A Dwedar, Dalia Abdel-sattar Mohammed
Background Although studies show that most people successfully control their asthma, polls consistently show that this is not the case in real life. The present study aimed to validate assessment of asthma control using a risk stratification approach in comparison with global strategy for asthma management and prevention (GINA) guidelines with particular attention to high-risk group of asthmatic patients. Patients and methods This was a prospective interventional cohort trial that enrolled 30 patients with asthma in the outpatient department of Ain Shams University Hospital between January 2019 and January 2020. There were 10 female patients and 20 male patients, with a mean age of 51.43 ± 14.94 years. They were enrolled and randomly grouped 1: 1 into group A, which followed asthma risk stratification therapy (ARST), and group B, with the standard GINA approach, within 1-year follow-up period. Following visit 1 in a 2-week interval as a washout period, there were five consecutive visits on 3 months apart, and then visit 6 at the end of treatment at a 2-week interval. All patients were subjected to the Asthma Control Test Questionnaire for assessment of asthma control by GINA approach and to objective control assessments in ARST by Morisky Medication Adherence Scale-8 for adherence assessment, pulmonary function test for evaluation of annual decline of forced expiratory volume in the first second, and the annual rate of exacerbations. Results The results obtained from visits 1 to 6 showed nonstatistically significant differences in forced expiratory volume in the first second (75 vs. 81.82 ml, P=0.820) and in adherence scale (Morisky Medication Adherence Scale-8) on visits 2–5 (40 vs. 17, P=0465), or the rate of exacerbation (two exacerbations in each group), with no statistically significant differences (0 vs. 13.3%, P=0.143) in group A and group B, respectively. On the contrary, the assessment of severity tools in ARST was based on the level of sustainability of the asthma stepwise categorization among the duration therapy. Using ARST for the aims of control and severity assessments on the studied group, in comparison with the GINA assessment approach, there were highly significant statistical differences in numbers of controlled patients as well as numbers of patients with mild and moderate asthma for severity assessments (t=13.263, P=0.001 vs. t=22.941, P=0.0001, respectively). It could be concluded that applying the GINA approach on studied group A revealed underestimation of control and probably overestimation of asthma severity, or better called asthma stability. Conclusion ARST is noninferior to the GINA approach in the norms of asthma control when objectivity was measured, whereas the levels of sustainability or stability among the duration therapy for assessment of asthma severity were statistically overestimated when measured by GINA. These measures could help most patients with asthma, and there should be a concerted action for their i
{"title":"Validation of asthma management approach according to risk factors","authors":"Riham Farouk, Gamal Abdel-latif, Ibrahim A Dwedar, Dalia Abdel-sattar Mohammed","doi":"10.4103/ecdt.ecdt_49_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_49_22","url":null,"abstract":"Background Although studies show that most people successfully control their asthma, polls consistently show that this is not the case in real life. The present study aimed to validate assessment of asthma control using a risk stratification approach in comparison with global strategy for asthma management and prevention (GINA) guidelines with particular attention to high-risk group of asthmatic patients. Patients and methods This was a prospective interventional cohort trial that enrolled 30 patients with asthma in the outpatient department of Ain Shams University Hospital between January 2019 and January 2020. There were 10 female patients and 20 male patients, with a mean age of 51.43 ± 14.94 years. They were enrolled and randomly grouped 1: 1 into group A, which followed asthma risk stratification therapy (ARST), and group B, with the standard GINA approach, within 1-year follow-up period. Following visit 1 in a 2-week interval as a washout period, there were five consecutive visits on 3 months apart, and then visit 6 at the end of treatment at a 2-week interval. All patients were subjected to the Asthma Control Test Questionnaire for assessment of asthma control by GINA approach and to objective control assessments in ARST by Morisky Medication Adherence Scale-8 for adherence assessment, pulmonary function test for evaluation of annual decline of forced expiratory volume in the first second, and the annual rate of exacerbations. Results The results obtained from visits 1 to 6 showed nonstatistically significant differences in forced expiratory volume in the first second (75 vs. 81.82 ml, P=0.820) and in adherence scale (Morisky Medication Adherence Scale-8) on visits 2–5 (40 vs. 17, P=0465), or the rate of exacerbation (two exacerbations in each group), with no statistically significant differences (0 vs. 13.3%, P=0.143) in group A and group B, respectively. On the contrary, the assessment of severity tools in ARST was based on the level of sustainability of the asthma stepwise categorization among the duration therapy. Using ARST for the aims of control and severity assessments on the studied group, in comparison with the GINA assessment approach, there were highly significant statistical differences in numbers of controlled patients as well as numbers of patients with mild and moderate asthma for severity assessments (t=13.263, P=0.001 vs. t=22.941, P=0.0001, respectively). It could be concluded that applying the GINA approach on studied group A revealed underestimation of control and probably overestimation of asthma severity, or better called asthma stability. Conclusion ARST is noninferior to the GINA approach in the norms of asthma control when objectivity was measured, whereas the levels of sustainability or stability among the duration therapy for assessment of asthma severity were statistically overestimated when measured by GINA. These measures could help most patients with asthma, and there should be a concerted action for their i","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"48 1","pages":"16 - 24"},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90712882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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