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Endobronchial inflammatory polyps: A rare clinical entity 支气管内炎性息肉:一种罕见的临床疾病
IF 0.1 Pub Date : 2023-01-01 DOI: 10.4103/ecdt.ecdt_60_22
Sharad Joshi, Nitesh Tayal, Rajesh Gupta, Ankit Bhatia
Endobronchial inflammatory polyps are one of the rarest benign bronchial tumors. Tumors of benign etiology are even rare. Inflammatory bronchial polyps are frequently solitary although rarely can be multifocal. We are presenting a rare case of multiple endobronchial inflammatory polyps presenting as pneumonia.
支气管内炎性息肉是一种罕见的支气管良性肿瘤。良性肿瘤甚至很少见。炎性支气管息肉通常是单发的,但很少是多灶性的。我们报告一例罕见的多发性支气管内炎性息肉,表现为肺炎。
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引用次数: 0
Effect of hypofractionated radiotherapy on lung functions in breast cancer patients 低分割放疗对乳腺癌患者肺功能的影响
IF 0.1 Pub Date : 2023-01-01 DOI: 10.4103/ecdt.ecdt_20_22
Enass Rezk, Aya Abdeldayem, A. Farag, H. Abdelhamid
Background Adjuvant hypofractionated radiotherapy (RT) used in the management of breast cancer cases, although reduce time and cost, may have serious effects due to the increased dose of radiation. Radiation-induced lung injury is an important side effect of thoracic radiation. Aim In our study, patients assessed by spirometry to detect acute changes in lung functions resulted from radiation exposure during the treatment of breast cancer. Patients and methods In this prospective study, 31 patients with breast cancer, who received adjuvant RT in Ain Shams University Hospitals, were assessed by spirometry before and 8 weeks after the end of RT. Radiation pneumonitis (RP) was graded using the Common Terminology Criteria for Adverse Events, version 5. Pulmonary function was evaluated by spirometry before and 8 weeks after finishing RT to detect changes in forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), FEV1/FVC ratio, forced expiratory flow at 25–75% of FVC (FEF25%–75%), and FEF50% of . Results Five (16.1%) patients developed symptomatic RP. Significant reduction was noticed in FVC and FEV1, while FEV1/FVC ratio, FEF25%–75%, and FEF50% were not significantly affected. It was also observed that FEV1 was sensitive in anticipating RP. Conclusion Spirometry parameters, FEV1 and FVC, significantly decreased after 8 weeks of RT ending, without significant decrease in other parameters, favoring restrictive lung injury pattern. Since most cancer breast patients who developed RP were asymptomatic, spirometry was found to be beneficial in identifying patients with risk of radiation-induced lung injury (RP).
背景辅助低分割放疗(RT)用于乳腺癌病例的治疗,虽然减少了时间和费用,但由于辐射剂量的增加,可能会产生严重的影响。放射性肺损伤是胸部放射治疗的一个重要副作用。目的在我们的研究中,通过肺量测定来检测乳腺癌治疗期间因辐射暴露引起的肺功能的急性变化。患者和方法在这项前瞻性研究中,在Ain Shams大学医院接受辅助放疗的31例乳腺癌患者在放疗前和放疗结束后8周通过肺活量测定法进行评估。使用不良事件通用术语标准第5版对放射性肺炎(RP)进行分级。在RT结束前和8周后通过肺活量测定法评估肺功能,检测用力肺活量(FVC)、第一秒用力呼气量(FEV1)、FEV1/FVC比值、FVC 25-75%时的用力呼气流量(FEF25%-75%)和ff50%时的用力呼气流量的变化。结果5例(16.1%)出现症状性RP。FVC和FEV1显著降低,FEV1/FVC比值、fef25% ~ 75%和FEF50%无显著影响。我们还观察到FEV1对预测RP很敏感。结论肺功能指标FEV1、FVC在RT结束8周后明显降低,其他指标无明显下降,有利于限制性肺损伤模式。由于大多数发生RP的乳腺癌患者是无症状的,因此肺活量测定法被发现有助于识别有辐射性肺损伤(RP)风险的患者。
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引用次数: 0
A randomized trial comparing the effects of electrical stimulation of the quadriceps muscle and decreased trigger sensitivity plus exercise breathing after discharge on mechanically ventilated patients with chronic obstructive pulmonary disease to those receiving standard care in terms of 30-day mortality, hospital readmission, and health-related quality of life 一项随机试验,比较慢性阻塞性肺疾病机械通气患者出院后电刺激股四头肌和降低触发敏感性加运动呼吸的效果,与接受标准治疗的患者在30天死亡率、再入院率和健康相关生活质量方面的影响
Pub Date : 2023-01-01 DOI: 10.4103/ecdt.ecdt_33_22
Ashraf Abdeen, Lamiaa Shaaban, Safaa A Mahran, Shereen Farghaly, Hend M Saleh
Abstract Background To compare the effectiveness of ES and TS plus exercise breathing after discharge on mechanically ventilated patients with chronic obstructive pulmonary disease (COPD) to those receiving standard care in terms of 30-day mortality, hospital readmission, and health-related quality of life (HRQOL). Patients and methods The current study was a randomized controlled trial. It included 108 newly admitted patients with COPD to RICU, Chest Department, Assiut University Hospital, Egypt, between June 2018 and May 2020. They were divided into two groups: group I received the usual care plus ES and TS plus breathing exercise, and group II received the usual care alone. Thirty-day mortality, hospital readmission, and HRQOL assessed by MFR-28 were recorded and evaluated. Student t test, Mann–Whitney U test, χ 2 test, and Fisher exact test were performed to analyze the data. Results A total of 108 patients with COPD were included. Early rehabilitation program (ES and TS) plus exercise breathing for patients with COPD in the ICU showed decreased 30-day mortality, decreased hospital readmission, and improved HRQOL as compared with patients with COPD who received usual care. Conclusion Patients with COPD who were treated with an early rehabilitation program (ES and TS) combined with exercise breathing had a better prognosis and a higher QOL. Clinical trial.gov The study was registered under NCT03253380.
背景:比较机械通气慢性阻塞性肺疾病(COPD)患者出院后ES和TS加运动呼吸与接受标准治疗的患者在30天死亡率、再入院率和健康相关生活质量(HRQOL)方面的有效性。本研究为随机对照试验。该研究包括2018年6月至2020年5月期间埃及阿西尤特大学医院RICU胸科108名新入院的COPD患者。将患者分为两组:第一组采用常规护理+ ES、TS +呼吸运动,第二组仅采用常规护理。记录并评价MFR-28评价的30天死亡率、再入院率和HRQOL。采用Student t检验、Mann-Whitney U检验、χ 2检验和Fisher精确检验对数据进行分析。结果共纳入108例COPD患者。与接受常规护理的COPD患者相比,ICU COPD患者的早期康复计划(ES和TS)加运动呼吸降低了30天死亡率,减少了再入院率,改善了HRQOL。结论早期康复方案(ES和TS)联合运动呼吸治疗COPD患者预后较好,生活质量较高。该研究注册号为NCT03253380。
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引用次数: 0
Asthma prevalence among medical students of jazan university, saudi arabia: A cross-sectional study 沙特阿拉伯吉赞大学医学院学生哮喘患病率:一项横断面研究
IF 0.1 Pub Date : 2023-01-01 DOI: 10.4103/ecdt.ecdt_50_22
Abdulrahman Hakami, Abuobaida Yassin, Meshal Bajoned, Reem Maashi, Amna Zila, Nuha Dilyh, Samar Dilyh, Fatima Ezzi, Maha Madkhali
Background Both adults and children experience bronchial asthma, which is the most common chronic respiratory condition. The prevalence of asthma varies widely by geography and age, with its prevalence ranging from 0.2 to 21.0% in adults. However, there are no data on the prevalence of asthma among adults in the Jazan Region, which is located in the southern part of Saudi Arabia. Objective To assess the prevalence of asthma among medical students in Jazan University, Jazan Region of Saudi Arabia. Methods In this cross-sectional study, the prevalence of asthma was determined using a modified and translated International Study of Asthma and Allergies in Childhood questionnaire. Adult students of health-related colleges at Jazan University constituted the target population in the region. Results There were 1210 responders, which included 654 (54.0%) males and 556 (46.0%) females. In total, 761 (62.9%) students (35.3% men) resided in rural areas, whereas 449 (37.1%) students resided in urban areas. Additionally, 20.2% of students experienced life-long wheezing. During the previous 12 months, 218 (18%) and 191 (15.8%) students experienced exercise-induced wheezing and nonexercise-induced wheezing, respectively. Furthermore, 188 (15.5%) students had a medical history of asthma, and the prevalence of asthma did not differ significantly between males and females (P=0.412). A physician confirmed that 13.7% of the participants had asthma. Conclusion Our results demonstrated a high frequency of asthma among the medical students of Jazan University in the Jazan Region. Asthma diagnosis was predicted using an identifiable questionnaire and without using physiological measures and laboratory factors.
成人和儿童都有支气管哮喘,这是最常见的慢性呼吸系统疾病。哮喘的患病率因地域和年龄而有很大差异,成人患病率从0.2%到21.0%不等。然而,没有关于吉赞地区成人哮喘患病率的数据,该地区位于沙特阿拉伯南部。目的了解沙特阿拉伯吉赞地区吉赞大学医学生哮喘患病率。方法在这项横断面研究中,使用一份经过修改和翻译的儿童哮喘和过敏国际研究问卷来确定哮喘的患病率。吉赞大学健康相关学院的成年学生构成了该地区的目标人群。结果应答者1210人,其中男性654人(54.0%),女性556人(46.0%)。总共有761名(62.9%)学生居住在农村地区(其中35.3%为男性),449名(37.1%)学生居住在城市地区。此外,20.2%的学生经历了终身喘息。在过去的12个月里,分别有218名(18%)和191名(15.8%)学生经历过运动性喘息和非运动性喘息。188名(15.5%)学生有哮喘病史,男女哮喘患病率差异无统计学意义(P=0.412)。一位医生证实,13.7%的参与者患有哮喘。结论吉赞大学医学生在吉赞地区哮喘发病率较高。使用可识别的问卷预测哮喘诊断,不使用生理测量和实验室因素。
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引用次数: 0
Noninvasive ventilation in patients with acute severe asthma: ‘Be Sure, Be vigilant’ 急性重症哮喘患者无创通气:“确保,保持警惕”
IF 0.1 Pub Date : 2023-01-01 DOI: 10.4103/ecdt.ecdt_32_22
Gopal Chawla, A. Esquinas
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引用次数: 0
The role of CD24 as a potential biomarker for malignant pleural mesothelioma CD24作为恶性胸膜间皮瘤潜在生物标志物的作用
Pub Date : 2023-01-01 DOI: 10.4103/ecdt.ecdt_11_23
Mohamed Shaaban Mousa, Ahmed Mamdooh Ghoname, Dalia Abd El-Kareem Ateya, Hamed A H Abdallah, Salwa Hassan Ahmed
Abstract Objectives Pleural mesothelioma is a rapidly progressing pleural neoplasm caused by asbestos exposure of a long latency around 30-40 years. Patients with mesothelioma are usually diagnosed at a late stage with poor outcomes in terms of morbidity and mortality with 6–12 months’ median survival. Despite the prohibited use of asbestos, malignant pleural mesothelioma is still increasingly being occurred in young age and female patients. Different un-standardized biomarkers have been used to diagnose MPM as mesothelin and febulin with controversial results, so we used CD 24 as a biomarker to diagnose and differentiate between different subtypes of malignant pleural mesothelioma. Materials and methods Our cohort study included total of fifty-nine patients with exudative pleural effusion. All patients underwent full history taking, clinical examination, blood tests (CBC, coagulation profile, liver and kidney functions), tapping of pleural effusion and to send pleural fluid investigations for LDH, albumin, total protein and albumin, then confirmed exudative pleural effusion patients were subjected to thoracic ultrasonography and medical thoracoscopy for the majority of cases or ultrasound guided biopsy in selected cases to obtain pleural biopsies for histopathology and then the examination of pleural biopsies for CD24 expression. Results Our study demonstrated the possibility of using CD24 as a biomarker in the immunostaining of pleural biopsies to differentiate between malignant pleural mesothelioma and pleural malignancy other than mesothelioma (18 mesothelioma cases versus 2 nonmesothelioma malignant cases) with high statistical significance P value < 0.001 and also it can discriminate between subtypes of mesothelioma as it showed marked significance in epithelioid subtype (12 epithelioid versus 1 sarcomatoid versus 5 biphasic subtypes) with more uptake by score +2 in epithelioid mesothelioma. Conclusions CD24 can be supposed to be a routine biomarker for immunohistochemistry of pleural tissue samples in diagnosis of mesothelioma and it can be used to differentiate between subtypes of malignant mesothelioma subtypes.
摘要目的胸膜间皮瘤是由石棉暴露引起的一种进展迅速的胸膜肿瘤,潜伏期长,约30-40年。间皮瘤患者通常在晚期诊断,发病率和死亡率较差,中位生存期为6-12个月。尽管禁止使用石棉,恶性胸膜间皮瘤仍然越来越多地发生在年轻和女性患者中。不同的非标准化生物标志物被用于诊断MPM,如间皮素和febulin,结果有争议,因此我们使用cd24作为生物标志物来诊断和区分恶性胸膜间皮瘤的不同亚型。材料与方法我们的队列研究共纳入59例渗出性胸腔积液患者。所有患者均进行了完整的病史记录、临床检查、血液检查(CBC、凝血特征、肝肾功能)、胸腔积液穿刺和胸腔积液检测LDH、白蛋白、总蛋白和白蛋白。确诊为渗出性胸腔积液的患者,多数行胸部超声及内科胸腔镜检查,部分病例行超声引导下活检,取胸膜活检进行组织病理学检查,再行胸膜活检检查CD24表达。结果CD24作为生物标志物在胸膜活检免疫染色中鉴别恶性胸膜间皮瘤和非间皮瘤的胸膜恶性肿瘤(18例间皮瘤对2例非间皮瘤恶性肿瘤)的可能性具有高度统计学意义P值<0.001,它也可以区分间皮瘤的亚型,因为它在上皮样亚型(12个上皮样亚型对1个肉瘤样亚型对5个双相亚型)中表现出显著的意义,上皮样间皮瘤的摄取评分为+2。结论CD24可作为胸膜组织标本免疫组化诊断间皮瘤的常规生物标志物,并可用于恶性间皮瘤亚型的鉴别。
{"title":"The role of CD24 as a potential biomarker for malignant pleural mesothelioma","authors":"Mohamed Shaaban Mousa, Ahmed Mamdooh Ghoname, Dalia Abd El-Kareem Ateya, Hamed A H Abdallah, Salwa Hassan Ahmed","doi":"10.4103/ecdt.ecdt_11_23","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_11_23","url":null,"abstract":"Abstract Objectives Pleural mesothelioma is a rapidly progressing pleural neoplasm caused by asbestos exposure of a long latency around 30-40 years. Patients with mesothelioma are usually diagnosed at a late stage with poor outcomes in terms of morbidity and mortality with 6–12 months’ median survival. Despite the prohibited use of asbestos, malignant pleural mesothelioma is still increasingly being occurred in young age and female patients. Different un-standardized biomarkers have been used to diagnose MPM as mesothelin and febulin with controversial results, so we used CD 24 as a biomarker to diagnose and differentiate between different subtypes of malignant pleural mesothelioma. Materials and methods Our cohort study included total of fifty-nine patients with exudative pleural effusion. All patients underwent full history taking, clinical examination, blood tests (CBC, coagulation profile, liver and kidney functions), tapping of pleural effusion and to send pleural fluid investigations for LDH, albumin, total protein and albumin, then confirmed exudative pleural effusion patients were subjected to thoracic ultrasonography and medical thoracoscopy for the majority of cases or ultrasound guided biopsy in selected cases to obtain pleural biopsies for histopathology and then the examination of pleural biopsies for CD24 expression. Results Our study demonstrated the possibility of using CD24 as a biomarker in the immunostaining of pleural biopsies to differentiate between malignant pleural mesothelioma and pleural malignancy other than mesothelioma (18 mesothelioma cases versus 2 nonmesothelioma malignant cases) with high statistical significance P value < 0.001 and also it can discriminate between subtypes of mesothelioma as it showed marked significance in epithelioid subtype (12 epithelioid versus 1 sarcomatoid versus 5 biphasic subtypes) with more uptake by score +2 in epithelioid mesothelioma. Conclusions CD24 can be supposed to be a routine biomarker for immunohistochemistry of pleural tissue samples in diagnosis of mesothelioma and it can be used to differentiate between subtypes of malignant mesothelioma subtypes.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135667820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of thrombocytopenia in coronavirus disease patients in comparison with patients with normal platelet count 冠状病毒病患者血小板减少对血小板计数正常患者的影响
Pub Date : 2023-01-01 DOI: 10.4103/ecdt.ecdt_121_22
Gehan M Elassal, Mahmoud M Mahmoud, Dina E Aly
Abstract Background Known as severe acute respiratory syndrome coronavirus 2, the severe acute respiratory syndrome coronavirus is a new coronavirus illness [coronavirus disease-2019 (COVID-19)], it spreads quickly over the world. Patients with COVID-19 frequently have changes in platelet count. The platelet count is a highly useful clinical tool for tracking patients with aggressive viral infections who have rapidly changing health conditions since it is a sensitive indicator of sickness severity. Aim To study thrombocytopenia as a prognostic factor in COVID-19 patients and its relation with the length of hospital stay and prognosis. Patients and methods A total of 60 COVID-19 patients were involved in the prospective study during the period from June 2020 to December 2020 who were admitted to the isolation hospital, Ain Shams University Hospitals. Then for each patient, complete blood count at admission was done, repeated on day 7, day 14, and day 21. Patients were followed regarding the length of hospital stay and mortality. Results Out of 60 patients, 10 (16.6%) patients were thrombocytopenic. The length of hospital stay was significantly higher in a thrombocytopenic group. There was a high statistically significant difference between the normal platelets count group and the thrombocytopenic groups regarding outcome ( P <0.001). In thrombocytopenic patients, five (50%) showed deterioration, four (40%) patients died and one patient in this group showed complete recovery. Conclusion Thrombocytopenia is associated with increased length of hospital stay and poor prognosis in patients with COVID-19.
背景严重急性呼吸综合征冠状病毒是一种新型冠状病毒疾病[冠状病毒病-2019 (COVID-19)],被称为严重急性呼吸综合征冠状病毒2,在全球范围内传播迅速。COVID-19患者血小板计数经常发生变化。血小板计数是一种非常有用的临床工具,用于跟踪具有快速变化的健康状况的侵袭性病毒感染患者,因为它是疾病严重程度的敏感指标。目的探讨血小板减少作为新冠肺炎患者预后的影响因素及其与住院时间和预后的关系。患者和方法前瞻性研究纳入2020年6月至2020年12月在艾因沙姆斯大学医院隔离医院住院的60例COVID-19患者。然后对每个患者在入院时进行全血细胞计数,在第7天、第14天和第21天重复。随访患者的住院时间和死亡率。结果60例患者中,血小板减少10例(16.6%)。血小板减少组住院时间明显增高。正常血小板计数组和血小板减少组在结果上有很高的统计学差异(P <0.001)。在血小板减少患者中,5例(50%)出现恶化,4例(40%)死亡,该组1例患者完全恢复。结论血小板减少与COVID-19患者住院时间延长和预后不良有关。
{"title":"The effect of thrombocytopenia in coronavirus disease patients in comparison with patients with normal platelet count","authors":"Gehan M Elassal, Mahmoud M Mahmoud, Dina E Aly","doi":"10.4103/ecdt.ecdt_121_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_121_22","url":null,"abstract":"Abstract Background Known as severe acute respiratory syndrome coronavirus 2, the severe acute respiratory syndrome coronavirus is a new coronavirus illness [coronavirus disease-2019 (COVID-19)], it spreads quickly over the world. Patients with COVID-19 frequently have changes in platelet count. The platelet count is a highly useful clinical tool for tracking patients with aggressive viral infections who have rapidly changing health conditions since it is a sensitive indicator of sickness severity. Aim To study thrombocytopenia as a prognostic factor in COVID-19 patients and its relation with the length of hospital stay and prognosis. Patients and methods A total of 60 COVID-19 patients were involved in the prospective study during the period from June 2020 to December 2020 who were admitted to the isolation hospital, Ain Shams University Hospitals. Then for each patient, complete blood count at admission was done, repeated on day 7, day 14, and day 21. Patients were followed regarding the length of hospital stay and mortality. Results Out of 60 patients, 10 (16.6%) patients were thrombocytopenic. The length of hospital stay was significantly higher in a thrombocytopenic group. There was a high statistically significant difference between the normal platelets count group and the thrombocytopenic groups regarding outcome ( P <0.001). In thrombocytopenic patients, five (50%) showed deterioration, four (40%) patients died and one patient in this group showed complete recovery. Conclusion Thrombocytopenia is associated with increased length of hospital stay and poor prognosis in patients with COVID-19.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135667830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physical and functional profile of ICU patients and correlation between functional scales (Physical function in ICU test – scored PFIT) ICU患者身体和功能状况及功能量表的相关性(ICU身体功能测试得分PFIT)
Pub Date : 2023-01-01 DOI: 10.4103/ecdt.ecdt_129_22
Mohamed A Tageldin, Riham H Raafat, Zeynab Noah
Abstract Background Each component of the original physical function ICU test (PFIT) had little clinical utility. Given the growing body of research on ICU strength and mobility, objective functional evaluations with great clinical usefulness are needed. Scoring the original PFIT improves clinical utility and research to compare ICU patient function and intervention responsiveness. Aim To evaluate the muscle strength and functional condition of ICU patients and link these procedures to the length of stay at Ain Shams University Hospital and outcome. Patients and methods The research included 40 patients who were admitted to the respiratory ICU either mechanically ventilated or not. Results There was high significant decrease in TLC; there was high significant increase in Hb, albumin, K, and Mg according to two assessment points. Most patients had a score of 3 of shoulder strength and knee strength but score 2 regarding Sit to stand assistance. There was high significant increase in PFIT-s in the second assessment. There was substantial enhancement in the second assessment compared with first assessment regarding different score results. Conclusion Based on the finding we conclude that, prolonged immobility during hospitalization results in loss of muscle strength and functional capacity. There was positive correlation between muscular strength and functional status, considering PFIT scales. The longer length of stay in ICU, the greater the loss of functional capacity in critical patients.
【摘要】背景原始物理功能ICU测试(PFIT)各组成部分临床应用价值较低。鉴于对ICU强度和活动能力的研究越来越多,需要有临床意义的客观功能评估。对原始PFIT评分提高了临床效用和比较ICU患者功能和干预反应性的研究。目的评估ICU患者的肌力和功能状况,并将这些操作与在艾因沙姆斯大学医院的住院时间和预后联系起来。患者与方法本研究纳入了40例机械通气或非机械通气入住呼吸ICU的患者。结果薄层色谱明显降低;根据两个评估点,Hb、白蛋白、K和Mg均有显著升高。大多数患者肩部力量和膝关节力量得分为3分,而坐立辅助得分为2分。在第二次评估中,PFIT-s显著增加。在不同的评分结果中,第二次评估与第一次评估相比有实质性的增强。结论住院期间长时间不活动可导致肌肉力量和功能能力的丧失。考虑到PFIT量表,肌肉力量与功能状态之间存在正相关。危重患者在ICU的住院时间越长,功能丧失越大。
{"title":"Physical and functional profile of ICU patients and correlation between functional scales (Physical function in ICU test – scored PFIT)","authors":"Mohamed A Tageldin, Riham H Raafat, Zeynab Noah","doi":"10.4103/ecdt.ecdt_129_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_129_22","url":null,"abstract":"Abstract Background Each component of the original physical function ICU test (PFIT) had little clinical utility. Given the growing body of research on ICU strength and mobility, objective functional evaluations with great clinical usefulness are needed. Scoring the original PFIT improves clinical utility and research to compare ICU patient function and intervention responsiveness. Aim To evaluate the muscle strength and functional condition of ICU patients and link these procedures to the length of stay at Ain Shams University Hospital and outcome. Patients and methods The research included 40 patients who were admitted to the respiratory ICU either mechanically ventilated or not. Results There was high significant decrease in TLC; there was high significant increase in Hb, albumin, K, and Mg according to two assessment points. Most patients had a score of 3 of shoulder strength and knee strength but score 2 regarding Sit to stand assistance. There was high significant increase in PFIT-s in the second assessment. There was substantial enhancement in the second assessment compared with first assessment regarding different score results. Conclusion Based on the finding we conclude that, prolonged immobility during hospitalization results in loss of muscle strength and functional capacity. There was positive correlation between muscular strength and functional status, considering PFIT scales. The longer length of stay in ICU, the greater the loss of functional capacity in critical patients.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135667898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Helicobacter pylori infection in chronic obstructive pulmonary disease 慢性阻塞性肺疾病幽门螺杆菌感染
IF 0.1 Pub Date : 2023-01-01 DOI: 10.4103/ecdt.ecdt_30_22
A. Dayem, Sara Afify, Haitham Mohamed
Context Chronic obstructive pulmonary disease (COPD) is a prevalent condition defined by chronic respiratory symptoms and difficult airflow caused by airway and/or alveolar disorders. Helicobacter pylori infection is a chronic stomach inflammation, which dramatically changes the gastric immune reaction, potentially leading to systemic consequences. Aims The study’s goal was to identify the effect of H. pylori infection in the severity of COPD. Settings and design Ain Shams University Hospital, a case–control observational study. Patients and methods The current study involved 40 patients who were diagnosed as COPD and 40 individuals as healthy controls with matched age and sex. All participants were evaluated by clinical assessment, chest radiograph, H. pylori stool Ag test, and spirometry with pre-bronchodilator and post-bronchodilator test. Statistical analysis used To compare quantitative variables unpaired t test was used and for qualitative variables χ2 test was used. Results H. pylori test results in patients and controls showed that 27 (67.5%) and 24 (60.0%) individuals were seropositive without significance between them. Seropositive H. pylori between the stages of COPD were 50% in the mild stage, 70% in the moderate stage, 70% in the severe stage, and 80% in the very severe stage, with no significant difference regarding the relation between the of H. pylori infection and severity of COPD. Conclusion There is high incidence of H. pylori infection in COPD patients and may have a role in the initiation and worsening of COPD in predisposed patients without significant relation between H. pylori and severity of COPD.
慢性阻塞性肺疾病(COPD)是一种由气道和/或肺泡疾病引起的慢性呼吸道症状和气流困难所定义的常见病。幽门螺杆菌感染是一种慢性胃炎,它会极大地改变胃的免疫反应,可能导致全身后果。该研究的目的是确定幽门螺杆菌感染对慢性阻塞性肺病严重程度的影响。背景和设计艾因沙姆斯大学医院,病例对照观察性研究。目前的研究包括40名被诊断为慢性阻塞性肺病的患者和40名年龄和性别匹配的健康对照组。所有参与者通过临床评估、胸片、幽门螺旋杆菌粪便抗原检测、肺量测定及支气管扩张剂前和扩张剂后试验进行评估。定量变量比较采用非配对t检验,定性变量比较采用χ2检验。结果患者与对照组幽门螺杆菌检测结果分别为27例(67.5%)和24例(60.0%)血清阳性,差异无统计学意义。不同COPD分期血清幽门螺杆菌阳性率分别为轻度50%、中度70%、重度70%、极重度80%,幽门螺杆菌感染与COPD严重程度的关系无统计学差异。结论幽门螺杆菌感染在COPD患者中发生率较高,可能在易感患者COPD的发生和恶化中起一定作用,但幽门螺杆菌感染与COPD严重程度无显著相关性。
{"title":"Helicobacter pylori infection in chronic obstructive pulmonary disease","authors":"A. Dayem, Sara Afify, Haitham Mohamed","doi":"10.4103/ecdt.ecdt_30_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_30_22","url":null,"abstract":"Context Chronic obstructive pulmonary disease (COPD) is a prevalent condition defined by chronic respiratory symptoms and difficult airflow caused by airway and/or alveolar disorders. Helicobacter pylori infection is a chronic stomach inflammation, which dramatically changes the gastric immune reaction, potentially leading to systemic consequences. Aims The study’s goal was to identify the effect of H. pylori infection in the severity of COPD. Settings and design Ain Shams University Hospital, a case–control observational study. Patients and methods The current study involved 40 patients who were diagnosed as COPD and 40 individuals as healthy controls with matched age and sex. All participants were evaluated by clinical assessment, chest radiograph, H. pylori stool Ag test, and spirometry with pre-bronchodilator and post-bronchodilator test. Statistical analysis used To compare quantitative variables unpaired t test was used and for qualitative variables χ2 test was used. Results H. pylori test results in patients and controls showed that 27 (67.5%) and 24 (60.0%) individuals were seropositive without significance between them. Seropositive H. pylori between the stages of COPD were 50% in the mild stage, 70% in the moderate stage, 70% in the severe stage, and 80% in the very severe stage, with no significant difference regarding the relation between the of H. pylori infection and severity of COPD. Conclusion There is high incidence of H. pylori infection in COPD patients and may have a role in the initiation and worsening of COPD in predisposed patients without significant relation between H. pylori and severity of COPD.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84382901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impulse oscillometry system as a new diagnostic tool in patients with chronic obstructive pulmonary disease 脉冲振荡测量系统在慢性阻塞性肺疾病诊断中的应用
IF 0.1 Pub Date : 2023-01-01 DOI: 10.4103/ecdt.ecdt_10_22
Nehal Elzahapy, R. Sharshar, A. Mohamed, W. El-Shimy
Background Both diagnosis and assessment of chronic obstructive pulmonary disease (COPD) are based mainly on pulmonary-function tests that are of very important significance in COPD. Impulse oscillometry is a noneffort-dependent method to assess the mechanical structure of the respiratory system. Objectives The study aims to evaluate impulse oscillometry system (IOS) as a diagnosis tool of COPD, in a trial to clarify the sensitivity and correlations of IOS parameters with COPD severity. Patients and methods The study included 30 healthy volunteers, group I (control group): 15 smokers, 15 nonsmokers, and 60 patients with COPD, group II: 30 patients with mild-to-moderate COPD, and group III: 30 patients with severe COPD. All participants were sequentially assessed by IOS to detect impedance, after this, spirometry was done, and both were repeated 15–45 min after the first dose of inhalation therapy (salbutamol). IOS is more sensitive in detecting small-airway affection in mild-to-moderate COPD than spirometry. Results In COPD, a significant increase in IOS-resistant parameters (R5, R5–20), reactance parameter (AX), and a decrease in reactance (X5) parameter was observed in two groups of COPD (groups II and III) if compared with control group I. IOS parameters significantly correlated with spirometric parameters, particularly large-airway parameters (R5 correlated with forced expiratory volume in the first second postbronchodilator in group II and group III), small-airway parameters (R5–20, X5, and AX correlated with maximal mid-expiratory flow postbronchodilator in group III). Conclusions IOS is very useful in detecting small-airway affection in mild and moderate COPD and could be done as an alternative to spirometric tests in severe COPD patients with more accurate grading.
背景慢性阻塞性肺疾病(COPD)的诊断和评估主要基于肺功能检查,肺功能检查在COPD中具有非常重要的意义。脉冲振荡法是一种评估呼吸系统机械结构的不费力的方法。目的评价脉冲振荡测量系统(impulse oscillation system, IOS)作为COPD的诊断工具,阐明IOS参数与COPD严重程度的敏感性和相关性。患者和方法本研究包括30名健康志愿者,第一组(对照组):15名吸烟者,15名不吸烟者,60名COPD患者,第二组:30名轻中度COPD患者,第三组:30名重度COPD患者。所有参与者依次进行IOS评估以检测阻抗,之后进行肺活量测定,并在第一剂量吸入治疗(沙丁胺醇)后15-45分钟重复这两项。IOS在检测轻中度COPD小气道影响方面比肺活量测定更敏感。导致慢性阻塞性肺病,显著增加IOS-resistant参数(R5, R5-20),电抗参数(AX),和减少电抗(X5)参数观察两组慢性阻塞性肺病(第二和第三组)与对照组相比i IOS参数与肺量测定的参数显著相关,特别是大气道参数(R5与用力呼气量在第一第二postbronchodilator组II和III), small-airway参数(R5-20 X5,结论IOS可用于检测轻中度COPD患者的小气道影响,可作为重度COPD患者肺活量测定的替代方法,分级更准确。
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Egyptian Journal of Chest Diseases and Tuberculosis
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