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Relation between bronchiectasis severity index and chest ultrasound in noncystic fibrosis bronchiectasis patient 非囊性纤维化支气管扩张患者支气管扩张严重程度指数与胸部超声的关系
IF 0.1 Q4 RESPIRATORY SYSTEM Pub Date : 2023-01-01 DOI: 10.4103/ecdt.ecdt_25_22
A. Abdelwahab, Mohammad Eldin, Hossam Abdel-Hamid
Background Bronchiectasis is a persistent dilatation of the proximal and medium-sized bronchi greater than 2 mm in diameter caused by weakening or fibrosis of the bronchial walls’ muscular and elastic components. Aim To measure the severity of bronchiectasis utilizing bronchiectasis-severity ratings in conjunction with transthoracic lung sonography and sputum-culture findings. Patients and methods This study was conducted at Chest Department Nasser Institute during the period from January 2020 to June 2021 and included 20 patients: nine females and 11 males with localized symptomatizing bronchiectasis. Results In total, 20 patients, 11 (55.0%) males and nine (45.0%) females, were included in this study where Pseudomonas aeruginosa was detected in 12 patients, Haemophilus influenza, and Klebsiella detected in six patients. There was a significant relation between FACED score, Bahalla score, and thoracic ultrasound (US) (P<0.05), also there is significant correlation between bronchiectasis severity index (BSI) score and FACED score (P<0.001). Meanwhile, there was insignificant relation between BSI score and thoracic US. Conclusion US is a valuable technique in relation to the BSI, FACED, and Bahalla scores.
背景:支气管扩张是由支气管壁肌肉和弹性成分减弱或纤维化引起的近端和中端支气管直径大于2mm的持续扩张。目的利用支气管扩张的严重程度分级,结合经胸肺超声检查和痰培养结果来衡量支气管扩张的严重程度。患者和方法本研究于2020年1月至2021年6月在胸科纳赛尔研究所进行,纳入20例局限性症状性支气管扩张患者:9例女性,11例男性。结果共纳入20例患者,其中男性11例(55.0%),女性9例(45.0%),其中铜绿假单胞菌12例,流感嗜血杆菌6例,克雷伯菌6例。face评分、Bahalla评分与胸腔镜超声(US)评分有显著相关性(P<0.05),支气管扩张严重程度指数(BSI)评分与face评分有显著相关性(P<0.001)。同时,BSI评分与胸椎US的相关性不显著。结论:US是一种与BSI、faces和Bahalla评分相关的有价值的技术。
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引用次数: 0
Pulmonary sarcomatoid carcinoma revealed by gingival metastases 肺肉瘤样癌表现为牙龈转移
IF 0.1 Q4 RESPIRATORY SYSTEM Pub Date : 2023-01-01 DOI: 10.4103/ecdt.ecdt_39_22
Bachouch Imen, N. Belloumi, S. Racha, Houcine Yoldez, C. Habouria, Jrad Sonia, Chermiti Fatma, E. M. Faouzi, Fenniche Soraya
Oral soft tissue metastases may be presented as rapidly progressive hyperplasic growths mimicking benign processes. Gingival metastases from pulmonary sarcomatoid carcinoma are extremely rare and have poor prognosis. We report in this publication a case of a 65-year-old male patient, presenting asarcomatoid carcinoma of the right upper pulmonary lobe. Clinical examination found a gingival swelling initially considered as a benign lesion. Gingival biopsy showed aspects of undifferentiated sarcomatoid carcinoma of pulmonary origin according to the immunohistochemical staining. Even rarely described, benign-mimiking lesions may be the first sign of an aggressive underlying malignancy, and, therefore, periodontists should be vigilant. Any abnormal lesion must be evaluated by histopathological investigations.
口腔软组织转移可能表现为快速进展的增生生长,模仿良性过程。摘要肺肉瘤样癌的牙龈转移极为罕见且预后较差。我们在此报告一例65岁男性患者,表现为右上肺叶asarcoma样癌。临床检查发现牙龈肿胀,起初认为是良性病变。根据免疫组织化学染色,牙龈活检显示肺源性未分化肉瘤样癌的各个方面。即使很少被描述,模仿良性的病变也可能是潜在恶性肿瘤侵袭的第一个征兆,因此,牙周病医生应该保持警惕。任何异常病变必须通过组织病理学检查来评估。
{"title":"Pulmonary sarcomatoid carcinoma revealed by gingival metastases","authors":"Bachouch Imen, N. Belloumi, S. Racha, Houcine Yoldez, C. Habouria, Jrad Sonia, Chermiti Fatma, E. M. Faouzi, Fenniche Soraya","doi":"10.4103/ecdt.ecdt_39_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_39_22","url":null,"abstract":"Oral soft tissue metastases may be presented as rapidly progressive hyperplasic growths mimicking benign processes. Gingival metastases from pulmonary sarcomatoid carcinoma are extremely rare and have poor prognosis. We report in this publication a case of a 65-year-old male patient, presenting asarcomatoid carcinoma of the right upper pulmonary lobe. Clinical examination found a gingival swelling initially considered as a benign lesion. Gingival biopsy showed aspects of undifferentiated sarcomatoid carcinoma of pulmonary origin according to the immunohistochemical staining. Even rarely described, benign-mimiking lesions may be the first sign of an aggressive underlying malignancy, and, therefore, periodontists should be vigilant. Any abnormal lesion must be evaluated by histopathological investigations.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"13 1","pages":"132 - 133"},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78226507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impulse oscillometry system as a new diagnostic tool in patients with chronic obstructive pulmonary disease 脉冲振荡测量系统在慢性阻塞性肺疾病诊断中的应用
IF 0.1 Q4 RESPIRATORY SYSTEM Pub Date : 2023-01-01 DOI: 10.4103/ecdt.ecdt_10_22
Nehal Elzahapy, R. Sharshar, A. Mohamed, W. El-Shimy
Background Both diagnosis and assessment of chronic obstructive pulmonary disease (COPD) are based mainly on pulmonary-function tests that are of very important significance in COPD. Impulse oscillometry is a noneffort-dependent method to assess the mechanical structure of the respiratory system. Objectives The study aims to evaluate impulse oscillometry system (IOS) as a diagnosis tool of COPD, in a trial to clarify the sensitivity and correlations of IOS parameters with COPD severity. Patients and methods The study included 30 healthy volunteers, group I (control group): 15 smokers, 15 nonsmokers, and 60 patients with COPD, group II: 30 patients with mild-to-moderate COPD, and group III: 30 patients with severe COPD. All participants were sequentially assessed by IOS to detect impedance, after this, spirometry was done, and both were repeated 15–45 min after the first dose of inhalation therapy (salbutamol). IOS is more sensitive in detecting small-airway affection in mild-to-moderate COPD than spirometry. Results In COPD, a significant increase in IOS-resistant parameters (R5, R5–20), reactance parameter (AX), and a decrease in reactance (X5) parameter was observed in two groups of COPD (groups II and III) if compared with control group I. IOS parameters significantly correlated with spirometric parameters, particularly large-airway parameters (R5 correlated with forced expiratory volume in the first second postbronchodilator in group II and group III), small-airway parameters (R5–20, X5, and AX correlated with maximal mid-expiratory flow postbronchodilator in group III). Conclusions IOS is very useful in detecting small-airway affection in mild and moderate COPD and could be done as an alternative to spirometric tests in severe COPD patients with more accurate grading.
背景慢性阻塞性肺疾病(COPD)的诊断和评估主要基于肺功能检查,肺功能检查在COPD中具有非常重要的意义。脉冲振荡法是一种评估呼吸系统机械结构的不费力的方法。目的评价脉冲振荡测量系统(impulse oscillation system, IOS)作为COPD的诊断工具,阐明IOS参数与COPD严重程度的敏感性和相关性。患者和方法本研究包括30名健康志愿者,第一组(对照组):15名吸烟者,15名不吸烟者,60名COPD患者,第二组:30名轻中度COPD患者,第三组:30名重度COPD患者。所有参与者依次进行IOS评估以检测阻抗,之后进行肺活量测定,并在第一剂量吸入治疗(沙丁胺醇)后15-45分钟重复这两项。IOS在检测轻中度COPD小气道影响方面比肺活量测定更敏感。导致慢性阻塞性肺病,显著增加IOS-resistant参数(R5, R5-20),电抗参数(AX),和减少电抗(X5)参数观察两组慢性阻塞性肺病(第二和第三组)与对照组相比i IOS参数与肺量测定的参数显著相关,特别是大气道参数(R5与用力呼气量在第一第二postbronchodilator组II和III), small-airway参数(R5-20 X5,结论IOS可用于检测轻中度COPD患者的小气道影响,可作为重度COPD患者肺活量测定的替代方法,分级更准确。
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引用次数: 0
Intrapleural streptokinase with pigtail catheter drainage versus medical thoracoscopy in complicated parapneumonic effusion 胸膜内链激酶联合猪尾导管引流与内科胸腔镜治疗复杂性肺旁积液的比较
Q4 RESPIRATORY SYSTEM Pub Date : 2023-01-01 DOI: 10.4103/ecdt.ecdt_3_23
Mervat A Abou Ismail, Ahmed Y Gad, Hatem A Elmallawany, Hany H Moussa
Abstract Context Parapneumonic effusion and empyema are commonly encountered by the pulmonologist. The decision regarding management is still challenging. Aim To compare outcomes of intrapleural streptokinase with pigtail catheter drainage versus medical thoracoscopy in complicated parapneumonic effusion. Methods and material Forty patients with complicated parapneumonic effusion were randomly allocated to one of two groups. Twenty patients underwent streptokinase intrapleural instillation via pigtail catheter. The other twenty patients underwent medical thoracoscopy. Results Intrapleural streptokinase instillation procedure was significantly shorter duration (12.80 ± 3.05 min) than medical thoracoscopy procedure (25.26 ± 4.66 min). However medical thoracoscopy showed a significant less days required to remove the drainage system (5.80 ± 1.70 days) versus intrapleural streptokinase instillation procedure (9.40 ± 3.91 days). Both groups had no significant complications. Lung expansion was achieved in 90% of patients treated with intrapleural streptokinase instillation and in 95% of patients treated with a medical thoracoscopy technique, with no statistically significant difference between the two groups. Conclusions Treatment of complicated parapneumonic effusions is undeniably interdisciplinary. Both intrapleural streptokinase with pigtail catheter drainage and medical thoracoscopy are safe and improve outcomes in complicated parapneumonic effusion. Medical thoracoscopy has an advantage of fewer days required for tube withdrawal. Pigtail insertion has an advantage of shorter procedure time compared to medical thoracoscopy
摘要背景:肺旁积液和肺气肿是肺科医生经常遇到的问题。关于管理的决定仍然具有挑战性。目的比较猪尾导管胸膜内链激酶引流与内科胸腔镜治疗复杂性肺旁积液的疗效。方法与材料将40例合并肺旁积液患者随机分为两组。20例患者经猪尾导管胸膜内注入链激酶。另外20名患者接受了内科胸腔镜检查。结果胸膜内链激酶滴注时间(12.80±3.05 min)明显短于内科胸腔镜(25.26±4.66 min)。然而,医学胸腔镜显示取出引流系统所需的时间(5.80±1.70天)明显少于胸膜内注入链激酶所需的时间(9.40±3.91天)。两组均无明显并发症。胸膜内注入链激酶治疗的患者肺扩张率为90%,内科胸腔镜治疗的患者肺扩张率为95%,两组间无统计学差异。结论复杂肺旁积液的治疗是一门跨学科的学科。胸膜内链激酶联合猪尾导管引流和内科胸腔镜治疗复杂性肺旁积液是安全的,并能改善预后。医学胸腔镜的优点是拔管所需的时间更短。与内科胸腔镜相比,猪尾插入术具有手术时间短的优点
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引用次数: 0
Helicobacter pylori infection in chronic obstructive pulmonary disease 慢性阻塞性肺疾病幽门螺杆菌感染
IF 0.1 Q4 RESPIRATORY SYSTEM Pub Date : 2023-01-01 DOI: 10.4103/ecdt.ecdt_30_22
A. Dayem, Sara Afify, Haitham Mohamed
Context Chronic obstructive pulmonary disease (COPD) is a prevalent condition defined by chronic respiratory symptoms and difficult airflow caused by airway and/or alveolar disorders. Helicobacter pylori infection is a chronic stomach inflammation, which dramatically changes the gastric immune reaction, potentially leading to systemic consequences. Aims The study’s goal was to identify the effect of H. pylori infection in the severity of COPD. Settings and design Ain Shams University Hospital, a case–control observational study. Patients and methods The current study involved 40 patients who were diagnosed as COPD and 40 individuals as healthy controls with matched age and sex. All participants were evaluated by clinical assessment, chest radiograph, H. pylori stool Ag test, and spirometry with pre-bronchodilator and post-bronchodilator test. Statistical analysis used To compare quantitative variables unpaired t test was used and for qualitative variables χ2 test was used. Results H. pylori test results in patients and controls showed that 27 (67.5%) and 24 (60.0%) individuals were seropositive without significance between them. Seropositive H. pylori between the stages of COPD were 50% in the mild stage, 70% in the moderate stage, 70% in the severe stage, and 80% in the very severe stage, with no significant difference regarding the relation between the of H. pylori infection and severity of COPD. Conclusion There is high incidence of H. pylori infection in COPD patients and may have a role in the initiation and worsening of COPD in predisposed patients without significant relation between H. pylori and severity of COPD.
慢性阻塞性肺疾病(COPD)是一种由气道和/或肺泡疾病引起的慢性呼吸道症状和气流困难所定义的常见病。幽门螺杆菌感染是一种慢性胃炎,它会极大地改变胃的免疫反应,可能导致全身后果。该研究的目的是确定幽门螺杆菌感染对慢性阻塞性肺病严重程度的影响。背景和设计艾因沙姆斯大学医院,病例对照观察性研究。目前的研究包括40名被诊断为慢性阻塞性肺病的患者和40名年龄和性别匹配的健康对照组。所有参与者通过临床评估、胸片、幽门螺旋杆菌粪便抗原检测、肺量测定及支气管扩张剂前和扩张剂后试验进行评估。定量变量比较采用非配对t检验,定性变量比较采用χ2检验。结果患者与对照组幽门螺杆菌检测结果分别为27例(67.5%)和24例(60.0%)血清阳性,差异无统计学意义。不同COPD分期血清幽门螺杆菌阳性率分别为轻度50%、中度70%、重度70%、极重度80%,幽门螺杆菌感染与COPD严重程度的关系无统计学差异。结论幽门螺杆菌感染在COPD患者中发生率较高,可能在易感患者COPD的发生和恶化中起一定作用,但幽门螺杆菌感染与COPD严重程度无显著相关性。
{"title":"Helicobacter pylori infection in chronic obstructive pulmonary disease","authors":"A. Dayem, Sara Afify, Haitham Mohamed","doi":"10.4103/ecdt.ecdt_30_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_30_22","url":null,"abstract":"Context Chronic obstructive pulmonary disease (COPD) is a prevalent condition defined by chronic respiratory symptoms and difficult airflow caused by airway and/or alveolar disorders. Helicobacter pylori infection is a chronic stomach inflammation, which dramatically changes the gastric immune reaction, potentially leading to systemic consequences. Aims The study’s goal was to identify the effect of H. pylori infection in the severity of COPD. Settings and design Ain Shams University Hospital, a case–control observational study. Patients and methods The current study involved 40 patients who were diagnosed as COPD and 40 individuals as healthy controls with matched age and sex. All participants were evaluated by clinical assessment, chest radiograph, H. pylori stool Ag test, and spirometry with pre-bronchodilator and post-bronchodilator test. Statistical analysis used To compare quantitative variables unpaired t test was used and for qualitative variables χ2 test was used. Results H. pylori test results in patients and controls showed that 27 (67.5%) and 24 (60.0%) individuals were seropositive without significance between them. Seropositive H. pylori between the stages of COPD were 50% in the mild stage, 70% in the moderate stage, 70% in the severe stage, and 80% in the very severe stage, with no significant difference regarding the relation between the of H. pylori infection and severity of COPD. Conclusion There is high incidence of H. pylori infection in COPD patients and may have a role in the initiation and worsening of COPD in predisposed patients without significant relation between H. pylori and severity of COPD.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"34 1","pages":"12 - 15"},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84382901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The outcome of pulmonary function tests and high-resolution computed tomography of chest in post-coronavirus disease 2019-confirmed cases after 3 months of recovery 2019冠状病毒病后确诊病例康复3个月后肺功能检查和胸部高分辨率计算机断层扫描结果
IF 0.1 Q4 RESPIRATORY SYSTEM Pub Date : 2023-01-01 DOI: 10.4103/ecdt.ecdt_41_22
YasserHamed Mostafa, M. Khalil, S. Hegazy, Marwa Daif
Background Coronavirus disease (COVID-19) is a recently prevalent infectious disease that is caused by a virus from the coronavirus family and causes acute respiratory syndrome. It is a pandemic catastrophe that has affected more than 60 million people around the world and has caused about 1.5 million deaths, as reported by the WHO. This disease affects the respiratory system and leads to different forms of symptoms and signs. Pneumonia is a common cause for hospitalization, with most patients treated in hospital wards and others requiring ICU. Although the number of complete recoveries from COVID-19 has increased, there is still concern about complications associated with the disease that appear after recovery. The studies that have looked at past types and other forms of coronavirus epidemics, such as SARS have shown that some cases had respiratory complications from the infection after being full recovered, as 36 and 30% of the entire study population had clinical and high-resolution computed tomography (HRCT) changes at 3 and 6 months after recovery, respectively. Mostly, the abnormalities seen in pulmonary function test (PFT) results are sequelae of diffusion capacity defect. In recovered cases of Middle East respiratory syndrome, 36% of patients showed HRCT sequelae at follow-up of 6 weeks, because of fibrosis. Data on COVID-19 indicate that prolonged disease and persistent symptoms show post-PFT affection and follow-up radiographic changes after recovery from COVID-19 as interstitial pulmonary changes and a degree of pulmonary vasculopathy. In recovered cases of COVID-19, capacity of diffusion is the commonest defect in lung function, followed by the restrictive pattern defects on spirometry; both are related to the degree of severity of pneumonic COVID-19. PFTs (involving spirometry as well as diffusion capacity) are considered as routine follow-up examinations for some of the recovered cases, especially severe cases. Rehabilitation programs of the respiratory system are an option strategy that might be considered. This study aims to show changes in pulmonary function and HRCT of chest in post-COVID-19-infected patients to detect long-term effects on the lungs after 3 months as obstructive or restrictive, or both, lung diseases. Patients and methods The study was conducted on 100 confirmed PCR-positive COVID-19 cases that were admitted to Ain Shams University Isolation Hospitals, and the follow-up was performed in the outpatient clinic. PCR samples (Combined nasopharyngeal and oropharyngeal swab) were taken after 3 months from discharge of patients above the age of 18 years who become negative with clinical improvement. PFT [spirometry and diffusion for carbon monoxide (DLCO)] and chest HRCT were done. All patients’ clinical data were recorded, and CT chest imaging data of these patients were correlated with the clinical data. Results A total of 100 patients were included in this study, where males represented 58% and female represented 4
冠状病毒病(COVID-19)是一种由冠状病毒家族病毒引起的近期流行的传染病,可导致急性呼吸综合征。据世界卫生组织报道,这是一场全球性的灾难,影响了全球6000多万人,造成约150万人死亡。这种疾病影响呼吸系统,并导致不同形式的症状和体征。肺炎是住院治疗的常见原因,大多数患者在医院病房治疗,其他患者需要重症监护病房。尽管COVID-19完全康复的人数有所增加,但人们仍然担心康复后出现的与疾病相关的并发症。对过去类型和其他形式的冠状病毒流行病(如SARS)进行的研究表明,一些病例在完全康复后出现了呼吸道并发症,因为整个研究人群中有36%和30%分别在康复后3个月和6个月出现了临床和高分辨率计算机断层扫描(HRCT)变化。肺功能试验(PFT)结果的异常多为弥散能力缺陷的后遗症。在恢复的中东呼吸综合征病例中,36%的患者在随访6周时出现HRCT后遗症,原因是纤维化。关于COVID-19的数据表明,病程延长和症状持续,在COVID-19康复后,pft后的影响和随访影像学变化表现为肺间质性改变和一定程度的肺血管病变。在康复病例中,扩散能力是最常见的肺功能缺陷,其次是肺活量测定的限制性缺陷;两者都与肺炎COVID-19的严重程度有关。PFTs(包括肺活量测定和扩散能力)被认为是一些康复病例,特别是重症病例的常规随访检查。呼吸系统的康复计划是一种可以考虑的选择策略。本研究旨在显示covid -19感染后患者肺功能和胸部HRCT的变化,以检测3个月后肺部阻塞性或限制性疾病或两者兼有对肺部的长期影响。患者与方法研究对象为艾因沙姆斯大学隔离医院收治的100例pcr阳性确诊COVID-19病例,并在门诊进行随访。年龄在18岁以上,临床好转后呈阴性的患者,出院3个月后采集PCR样本(鼻咽口咽联合拭子)。进行肺量测定和一氧化碳弥散(DLCO)及胸部HRCT检查。记录所有患者的临床资料,并将这些患者的CT胸部成像资料与临床资料相关联。结果共纳入100例患者,其中男性占58%,女性占42%。本研究病例的平均±SD年龄为45.05±11.80岁,年龄范围为20 ~ 79岁。基于治疗前和治疗后3个月HRCT胸部表现的新冠肺炎患者CT胸部严重程度评分(SS)异常呈高度显著相关(P=0.000)。研究组出院3个月后PFT表现为限制性型占14.9%,梗阻性占17.8%,梗阻性合并限制性占5.9%。研究组DLCO异常与年龄有显著相关性(P=0.032),研究组出院后PFT和HRCT胸部SS异常有显著相关性(P<0.001)。实验组患者治疗3个月后DLCO与HRCT胸部SS异常表现与治疗前有显著相关性(P=0.000),其他PFT与HRCT胸部SS异常表现与治疗前无显著相关性(P=0.001)。研究组HRCT胸部SS与治疗后(P=0.003)和治疗前(P=0.000)年龄有显著相关性。本队列研究提供了出院后长期动态后遗症和肺功能变化。结论3个月时检测的dlco预测值是与COVID-19重症呼吸道相关的最重要因素,是COVID-19恢复期患者任何普通基本活动受损的原因。胸部影像学表现必须结合其他功能参数进行分析,以提供对疾病的准确评估。这些发现强调了在严重和危重型COVID-19感染后进行全面随访并适当管理肺部后果的重要性。
{"title":"The outcome of pulmonary function tests and high-resolution computed tomography of chest in post-coronavirus disease 2019-confirmed cases after 3 months of recovery","authors":"YasserHamed Mostafa, M. Khalil, S. Hegazy, Marwa Daif","doi":"10.4103/ecdt.ecdt_41_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_41_22","url":null,"abstract":"Background Coronavirus disease (COVID-19) is a recently prevalent infectious disease that is caused by a virus from the coronavirus family and causes acute respiratory syndrome. It is a pandemic catastrophe that has affected more than 60 million people around the world and has caused about 1.5 million deaths, as reported by the WHO. This disease affects the respiratory system and leads to different forms of symptoms and signs. Pneumonia is a common cause for hospitalization, with most patients treated in hospital wards and others requiring ICU. Although the number of complete recoveries from COVID-19 has increased, there is still concern about complications associated with the disease that appear after recovery. The studies that have looked at past types and other forms of coronavirus epidemics, such as SARS have shown that some cases had respiratory complications from the infection after being full recovered, as 36 and 30% of the entire study population had clinical and high-resolution computed tomography (HRCT) changes at 3 and 6 months after recovery, respectively. Mostly, the abnormalities seen in pulmonary function test (PFT) results are sequelae of diffusion capacity defect. In recovered cases of Middle East respiratory syndrome, 36% of patients showed HRCT sequelae at follow-up of 6 weeks, because of fibrosis. Data on COVID-19 indicate that prolonged disease and persistent symptoms show post-PFT affection and follow-up radiographic changes after recovery from COVID-19 as interstitial pulmonary changes and a degree of pulmonary vasculopathy. In recovered cases of COVID-19, capacity of diffusion is the commonest defect in lung function, followed by the restrictive pattern defects on spirometry; both are related to the degree of severity of pneumonic COVID-19. PFTs (involving spirometry as well as diffusion capacity) are considered as routine follow-up examinations for some of the recovered cases, especially severe cases. Rehabilitation programs of the respiratory system are an option strategy that might be considered. This study aims to show changes in pulmonary function and HRCT of chest in post-COVID-19-infected patients to detect long-term effects on the lungs after 3 months as obstructive or restrictive, or both, lung diseases. Patients and methods The study was conducted on 100 confirmed PCR-positive COVID-19 cases that were admitted to Ain Shams University Isolation Hospitals, and the follow-up was performed in the outpatient clinic. PCR samples (Combined nasopharyngeal and oropharyngeal swab) were taken after 3 months from discharge of patients above the age of 18 years who become negative with clinical improvement. PFT [spirometry and diffusion for carbon monoxide (DLCO)] and chest HRCT were done. All patients’ clinical data were recorded, and CT chest imaging data of these patients were correlated with the clinical data. Results A total of 100 patients were included in this study, where males represented 58% and female represented 4","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"16 1","pages":"46 - 57"},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90910439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Noninvasive ventilation in acute exacerbation of interstitial lung diseases 无创通气在间质性肺疾病急性加重期中的应用
IF 0.1 Q4 RESPIRATORY SYSTEM Pub Date : 2023-01-01 DOI: 10.4103/ecdt.ecdt_40_22
Naglaa F Ahmed, Amany Abou Zeid, Mai Abo Elhasab, Gihan S. ABO ELWAFA
Introduction Noninvasive ventilation (NIV) has been recognized as a mean to avoid intubation and to reduce the risk of complications. Aims To study the role of NIV in acute respiratory failure in patients with interstitial lung diseases (ILD). Settings and design This was a prospective study. Patients and methods The present study included 30 mechanically ventilated patients through noninvasive masks subjected basically to informed consent, clinical data collection, laboratory investigations, chest radiograph, and arterial blood gas samples. Results A total of 20 patients were found to be survivors, whereas 10 patients were found to be nonsurvivors. The most common type of ILD in our study was hypersensitivity pneumonitis (53.3% of all patients) with fibrosis, and ground glass opacities were the most common radiological findings on high-resolution computed tomography, and moderate restrictive pattern in pulmonary function tests. Infection was the main cause of exacerbation as evidenced by fever, elevated total leukocytic count, staff neutrophilic count, and erythrocyte sedimentation rate. None of our patients developed complications or intolerance to NIV. Conclusion There was improvement in oxygenation parameters, so NIV could be a valuable option for management of acute type I mild to moderate respiratory failure in patients with ILD.
无创通气(NIV)已被认为是避免插管和降低并发症风险的一种手段。目的探讨NIV在间质性肺疾病(ILD)患者急性呼吸衰竭中的作用。本研究为前瞻性研究。患者与方法本研究纳入30例无创口罩机械通气患者,基本遵循知情同意、临床资料收集、实验室检查、胸片、动脉血气采集等原则。结果存活患者20例,未存活患者10例。在我们的研究中,最常见的ILD类型是伴有纤维化的过敏性肺炎(占所有患者的53.3%),高分辨率计算机断层扫描中最常见的影像学表现是毛玻璃影,肺功能检查中最常见的是中度限制性模式。感染是加重的主要原因,表现为发热、白细胞总数、工作人员嗜中性粒细胞计数和红细胞沉降率升高。我们的患者没有出现并发症或不耐受NIV。结论氧合参数有改善,因此NIV可能是治疗ILD患者急性I型轻中度呼吸衰竭的一种有价值的选择。
{"title":"Noninvasive ventilation in acute exacerbation of interstitial lung diseases","authors":"Naglaa F Ahmed, Amany Abou Zeid, Mai Abo Elhasab, Gihan S. ABO ELWAFA","doi":"10.4103/ecdt.ecdt_40_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_40_22","url":null,"abstract":"Introduction Noninvasive ventilation (NIV) has been recognized as a mean to avoid intubation and to reduce the risk of complications. Aims To study the role of NIV in acute respiratory failure in patients with interstitial lung diseases (ILD). Settings and design This was a prospective study. Patients and methods The present study included 30 mechanically ventilated patients through noninvasive masks subjected basically to informed consent, clinical data collection, laboratory investigations, chest radiograph, and arterial blood gas samples. Results A total of 20 patients were found to be survivors, whereas 10 patients were found to be nonsurvivors. The most common type of ILD in our study was hypersensitivity pneumonitis (53.3% of all patients) with fibrosis, and ground glass opacities were the most common radiological findings on high-resolution computed tomography, and moderate restrictive pattern in pulmonary function tests. Infection was the main cause of exacerbation as evidenced by fever, elevated total leukocytic count, staff neutrophilic count, and erythrocyte sedimentation rate. None of our patients developed complications or intolerance to NIV. Conclusion There was improvement in oxygenation parameters, so NIV could be a valuable option for management of acute type I mild to moderate respiratory failure in patients with ILD.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"40 1","pages":"99 - 104"},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77597960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The effect of coronavirus disease 2019 severity on male sexual functions among patients on follow-up after hospital discharge 2019冠状病毒病严重程度对患者出院后随访男性性功能的影响
IF 0.1 Q4 RESPIRATORY SYSTEM Pub Date : 2023-01-01 DOI: 10.4103/ecdt.ecdt_68_22
M. Mousa, M. Elshazly, M. E. El Salam, Salwa Ahmed, A. Tantawy
Objectives Severe acute respiratory syndrome coronavirus 2 has infected millions of people worldwide with extensive affection and damage to body systems and organs; hence, the study of post-coronavirus disease (COVID) sequences is mandatory. Till now, reports are upcoming on the considerable effects of COVID-19 on male sexual health with no final data. Patients and methods Our cohort study included 76 male COVID-19-infected patients, confirmed positive via nasopharyngeal PCR swab. The rationale of this study was to estimate the influence of clinical, laboratory, and radiological severity parameters of COVID-19 on male erectile dysfunction based on erectile scores and male sex hormones (follicle-stimulating hormone, luteinizing hormone, testosterone, and estradiol). Results Our results have demonstrated a highly statistically significant correlation between COVID-19 severity (mild, moderate, and severe cases) and both erectile scores (erection hardness score and International Index of Erectile Dysfunction-5) and testosterone hormones at first and third month after COVID (P<0.001), except for testosterone level at third month and COVID-19 severity, which showed a statistically significant difference, with P value of 0.031. Conclusions The current study correlated the effect of COVID-19 severity in the terms of clinical, laboratory, and radiological presentations on male sexual dysfunction (erectile scores and testosterone hormone) at first and third month after hospital discharge, with statistical significance being highly affected in severe rather than moderate and mild cases. This strengthens the obvious effect of COVID-19 infection on male sexual dysfunction.
严重急性呼吸综合征冠状病毒2型已感染全球数百万人,对身体系统和器官造成广泛影响和损害;因此,对冠状病毒后疾病(COVID)序列的研究是必须的。到目前为止,关于COVID-19对男性性健康的重大影响的报告即将发布,但没有最终数据。患者与方法本队列研究纳入76例男性covid -19感染患者,经鼻咽PCR拭子确诊为阳性。本研究的基本原理是根据勃起评分和男性性激素(促卵泡激素、黄体生成素、睾酮和雌二醇)来评估COVID-19临床、实验室和放射学严重程度参数对男性勃起功能障碍的影响。结果我们的研究结果显示,COVID-19严重程度(轻、中、重度)与勃起评分(勃起硬度评分、国际勃起功能障碍指数-5)和睾酮激素在COVID-19后第1个月和第3个月均有高度统计学意义(P<0.001),但第3个月睾酮水平与COVID-19严重程度差异有统计学意义,P值为0.031。结论本研究将COVID-19严重程度在临床、实验室和影像学表现方面对出院后1个月和3个月男性性功能障碍(勃起评分和睾酮激素)的影响联系起来,重症患者受影响程度高,而中轻症患者受影响程度高,差异有统计学意义。这进一步强化了新冠病毒感染对男性性功能障碍的明显影响。
{"title":"The effect of coronavirus disease 2019 severity on male sexual functions among patients on follow-up after hospital discharge","authors":"M. Mousa, M. Elshazly, M. E. El Salam, Salwa Ahmed, A. Tantawy","doi":"10.4103/ecdt.ecdt_68_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_68_22","url":null,"abstract":"Objectives Severe acute respiratory syndrome coronavirus 2 has infected millions of people worldwide with extensive affection and damage to body systems and organs; hence, the study of post-coronavirus disease (COVID) sequences is mandatory. Till now, reports are upcoming on the considerable effects of COVID-19 on male sexual health with no final data. Patients and methods Our cohort study included 76 male COVID-19-infected patients, confirmed positive via nasopharyngeal PCR swab. The rationale of this study was to estimate the influence of clinical, laboratory, and radiological severity parameters of COVID-19 on male erectile dysfunction based on erectile scores and male sex hormones (follicle-stimulating hormone, luteinizing hormone, testosterone, and estradiol). Results Our results have demonstrated a highly statistically significant correlation between COVID-19 severity (mild, moderate, and severe cases) and both erectile scores (erection hardness score and International Index of Erectile Dysfunction-5) and testosterone hormones at first and third month after COVID (P<0.001), except for testosterone level at third month and COVID-19 severity, which showed a statistically significant difference, with P value of 0.031. Conclusions The current study correlated the effect of COVID-19 severity in the terms of clinical, laboratory, and radiological presentations on male sexual dysfunction (erectile scores and testosterone hormone) at first and third month after hospital discharge, with statistical significance being highly affected in severe rather than moderate and mild cases. This strengthens the obvious effect of COVID-19 infection on male sexual dysfunction.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"36 1","pages":"58 - 64"},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85211735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison between thoracoscopic pleural cryobiopsy and conventional forceps biopsy in diagnosis of exudative pleural effusion: Assiut University experience 胸腔镜胸膜冷冻活检与常规产钳活检诊断渗出性胸腔积液的比较:Assiut大学的经验
Q4 RESPIRATORY SYSTEM Pub Date : 2023-01-01 DOI: 10.4103/ecdt.ecdt_125_22
Reham M El-Morshedy, Maha M El-kholy, Nermeen A M H Kamel, Samiaa H Sadek, Alaa S Abdel Ghany, Marwan N Mohamed
Abstract Context Exudative pleural effusion is a diagnostic dilemma that includes many steps; one of them is obtaining a definite diagnosis through pleural biopsy. Cryoprobes are being increasingly used for obtaining larger specimens with fewer crush artifacts. However, the safety and feasibility of cryoprobe biopsy compared with standard forceps for pleural biopsy have not been fully assessed. Aims To evaluate the diagnostic value, size, and quality of the specimens obtained by flexible cryoprobe in comparison with those obtained by flexible forceps probe during medical thoracoscopy in patients with exudative pleural effusion and to assess the possible complications from the procedure. Settings and design This interventional prospective study was carried out at the endoscopy unit at Chest Department and Tuberculosis Assiut University Hospital. Patients and methods This study included 60 patients with undiagnosed exudative pleural effusion. Medical thoracoscopy was carried out for all the patients, and pleural biopsies were taken from the parietal pleura using a conventional rigid forceps probe and flexible cryoprobe in the same settings. Results Cryoprobe biopsy established a definite diagnosis in 55/60, with 91.6% diagnostic yield, whereas forceps biopsy had a definite diagnosis in 53/60, with 88.3% diagnostic yield. The size of cryoprobe biopsy was significantly larger in comparison with the forceps biopsy (26.56 ± 22.16 vs. 17.38 ± 12.08 mm 2 ; P <0.001). The depth of pleural biopsy was evaluated by the presence of extrapleural fat cells, which were significantly higher in cryoprobe biopsy in comparison with forceps biopsy [21 (35%) vs. 11 (18.3%); P =0.03]. There were no significant complications or procedure-related deaths. Conclusions Cryobiopsy is a possible safe and effective alternative to conventional forceps probe biopsy in the diagnosis of exudative pleural effusion with a larger, deeper, and less number of biopsies. It was also found that cryoprobe biopsy had a better diagnostic yield, sensitivity, and accuracy.
摘要背景渗出性胸腔积液是一个诊断难题,包括许多步骤;其中之一是通过胸膜活检得到明确的诊断。冷冻探针越来越多地用于获得更大的标本,更少的挤压伪影。然而,冷冻探针活检与标准钳进行胸膜活检的安全性和可行性尚未得到充分评估。目的比较医用胸腔镜下柔性冷冻探头与柔性钳探头对胸腔渗出性积液的诊断价值、标本的大小和质量,并对其可能出现的并发症进行评价。背景和设计本介入前瞻性研究在阿西尤特大学医院胸科内窥镜科进行。患者与方法本研究纳入60例未确诊的渗出性胸腔积液患者。所有患者均接受内科胸腔镜检查,并在相同环境下使用常规刚性钳探针和柔性冷冻探针从胸膜壁层进行胸膜活检。结果冷冻活检确诊率为55/60,诊断率为91.6%;钳活检确诊率为53/60,诊断率为88.3%。冷冻探针活检组织的大小明显大于钳活检组织(26.56±22.16 vs. 17.38±12.08 mm 2;P & lt; 0.001)。通过胸膜外脂肪细胞的存在来评估胸膜活检的深度,与钳活检相比,冷冻探针活检的胸膜外脂肪细胞明显更高[21(35%)比11 (18.3%);P = 0.03)。无明显并发症或手术相关死亡。结论低温活检在诊断渗出性胸腔积液中具有较大、较深、较少活检次数的优点,可替代传统的钳探针活检,是一种安全有效的方法。我们还发现冷冻活检具有更好的诊断率、敏感性和准确性。
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引用次数: 0
Prevalence and risk factors of multidrug-resistant tuberculosis in Jazan, Saudi Arabia 沙特阿拉伯吉赞市耐多药结核病的患病率和危险因素
Q4 RESPIRATORY SYSTEM Pub Date : 2023-01-01 DOI: 10.4103/ecdt.ecdt_113_22
Wael Abdelfattah, Majid A Darraj, Abuobaida K Yassin, Heba M Shalaby
Abstract Background Drug-resistant tuberculosis (DR-TB) is a global challenge. Owing to its high annual mortality and morbidity rates, as stated in the annual global TB reports provided by WHO, the prevalence of multidrug-resistant tuberculosis (MDR-TB) or rifampicin-resistant tuberculosis was shown to be increasing worldwide in 2021. Patients with tuberculosis from 2018 to 2022 represented ~40 million individuals, including 1.5 million with DR-TB. The study’s goal was to identify MDR-TB prevalence and risk factors in Jazan, Saudi Arabia. Patients and methods The research was done on 114 patients diagnosed with pulmonary TB in Jazan Chest Hospital from January to April, 2019. Demographic data were collected. Monteux test, chest radiograph, sputum smear, and Lowenstein–Jensen culture were performed for all patients with pulmonary TB. Patients were allocated in either group A, with 103 (90.4%) patients, if they had Mycobacterium tuberculosis -susceptible isolates, or in group B, with 11 (9.7%) patients, if they had M. tuberculosis -resistant isolates. Results The observed overall DR-TB prevalence was 9.7%. The proportion of MDR isolates was 7%, polyresistant isolate TB was 0.9%, rifampicin-resistant tuberculosis was 0.9%, and ethambutol-resistant TB was 0.9%. Females were more in group B (54.5%) than in group A (26.2%). Unmarried patients were higher in group A (60.2%) than in group B (29.3%). Comorbidities had significant values in the drug-resistant groups (90.9%). Conclusion The study showed that screening and treatment of DR-TB are crucial for the control of TB in Jazan and Saudi Arabia as a whole.
背景耐药结核病(DR-TB)是一个全球性的挑战。正如世卫组织提供的年度全球结核病报告所述,由于耐多药结核病(MDR-TB)或耐利福平结核病的年死亡率和发病率很高,2021年全球范围内的流行率呈上升趋势。从2018年到2022年,结核病患者约为4000万人,其中包括150万耐药结核病患者。这项研究的目标是确定沙特阿拉伯吉赞市耐多药结核病的流行情况和危险因素。患者与方法对2019年1 - 4月在吉赞胸科医院诊断为肺结核的114例患者进行研究。收集了人口统计数据。所有肺结核患者均行蒙托试验、胸片、痰涂片和洛温斯坦-詹森培养。患者被分配到A组,103例(90.4%)患者,如果他们有结核分枝杆菌敏感的分离株,或B组,11例(9.7%)患者,如果他们有结核分枝杆菌耐药的分离株。结果观察到耐药结核总患病率为9.7%。耐多药结核分枝杆菌占7%,耐多药结核分枝杆菌占0.9%,耐利福平结核分枝杆菌占0.9%,耐乙胺丁醇结核分枝杆菌占0.9%。B组女性(54.5%)多于A组(26.2%)。未婚患者A组(60.2%)高于B组(29.3%)。合并症在耐药组有显著的价值(90.9%)。结论本研究表明,筛查和治疗耐药结核病对吉赞和沙特阿拉伯整个地区的结核病控制至关重要。
{"title":"Prevalence and risk factors of multidrug-resistant tuberculosis in Jazan, Saudi Arabia","authors":"Wael Abdelfattah, Majid A Darraj, Abuobaida K Yassin, Heba M Shalaby","doi":"10.4103/ecdt.ecdt_113_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_113_22","url":null,"abstract":"Abstract Background Drug-resistant tuberculosis (DR-TB) is a global challenge. Owing to its high annual mortality and morbidity rates, as stated in the annual global TB reports provided by WHO, the prevalence of multidrug-resistant tuberculosis (MDR-TB) or rifampicin-resistant tuberculosis was shown to be increasing worldwide in 2021. Patients with tuberculosis from 2018 to 2022 represented ~40 million individuals, including 1.5 million with DR-TB. The study’s goal was to identify MDR-TB prevalence and risk factors in Jazan, Saudi Arabia. Patients and methods The research was done on 114 patients diagnosed with pulmonary TB in Jazan Chest Hospital from January to April, 2019. Demographic data were collected. Monteux test, chest radiograph, sputum smear, and Lowenstein–Jensen culture were performed for all patients with pulmonary TB. Patients were allocated in either group A, with 103 (90.4%) patients, if they had Mycobacterium tuberculosis -susceptible isolates, or in group B, with 11 (9.7%) patients, if they had M. tuberculosis -resistant isolates. Results The observed overall DR-TB prevalence was 9.7%. The proportion of MDR isolates was 7%, polyresistant isolate TB was 0.9%, rifampicin-resistant tuberculosis was 0.9%, and ethambutol-resistant TB was 0.9%. Females were more in group B (54.5%) than in group A (26.2%). Unmarried patients were higher in group A (60.2%) than in group B (29.3%). Comorbidities had significant values in the drug-resistant groups (90.9%). Conclusion The study showed that screening and treatment of DR-TB are crucial for the control of TB in Jazan and Saudi Arabia as a whole.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135667642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Egyptian Journal of Chest Diseases and Tuberculosis
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