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Schizophrenia, substance use disorders and medical co-morbidity 精神分裂症、药物使用障碍和医疗并发症
IF 1.6 4区 医学 Q4 HEALTH POLICY & SERVICES Pub Date : 2000-07-19 DOI: 10.1002/1099-176X(200003)3:1<27::AID-MHP67>3.0.CO;2-P
Barbara Dickey, Hocine Azeni, Roger Weiss, Lloyd Sederer

Objectives:

This study compared medical treatment costs of adults with schizophrenia to adults with both substance use disorders and schizophrenia.

Methods:

This cross-sectional observational study used a paid claims data base to identify 6884 adults treated for schizophrenia. Twenty percent of these also had substance use disorder. We report the costs and likelihood of hospitalization for eight common medical diseases, and the categories of injuries and poisoning, and ill defined conditions. Multivariate analyses were used to adjust rates of treatment for age and sex differences in the comparison groups.

Results:

There were higher rates of treatment for five of the eight medical disorders, higher treatment costs for two of the medical disorders and much higher costs for psychiatric treatment among those with comorbid substance use disorders. Both groups had high rates of treatment in the categories of injury and poisoning and ill defined conditions.

Conclusions:

Closer working relationships among mental health and medical professionals are needed to care for those with schizophrenia and substance use disorders: first, greater attention to the treatment of substance use disorders may improve the health status of those with schizophrenia, reduce their costly medical and psychiatric care and stabilize their psychiatric condition, and second, continuity of care among professionals may promote willingness to seek medical attention or alleviate misunderstandings when adults with schizophrenia present with medical problems. Copyright © 2000 John Wiley & Sons, Ltd.

目的:本研究比较了患有精神分裂症的成年人与同时患有物质使用障碍和精神分裂症患者的医疗费用。方法:这项横断面观察性研究使用付费索赔数据库来识别6884名接受精神分裂症治疗的成年人。其中20%的人也有物质使用障碍。我们报告了八种常见疾病的住院费用和可能性,以及受伤和中毒的类别,以及不明确的情况。多变量分析用于调整比较组中年龄和性别差异的治疗率。结果:在共病药物使用障碍患者中,八种医疗障碍中有五种的治疗率较高,两种医疗障碍的治疗费用较高,精神治疗费用高得多。两组患者在受伤、中毒和不明情况方面的治疗率都很高。结论:需要心理健康和医疗专业人员之间建立更密切的工作关系来照顾精神分裂症和物质使用障碍患者:首先,更加重视物质使用障碍的治疗可以改善精神分裂症患者的健康状况,减少他们昂贵的医疗和精神护理,稳定他们的精神状况;其次,专业人员的连续护理可能会提高寻求医疗护理的意愿,或在患有精神分裂症的成年人出现医疗问题时减轻误解。版权所有©2000 John Wiley&;有限公司。
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引用次数: 39
The labor market consequences of family illness 家庭疾病对劳动力市场的影响
IF 1.6 4区 医学 Q4 HEALTH POLICY & SERVICES Pub Date : 2000-05-31 DOI: 10.1002/(SICI)1099-176X(199912)2:4<183::AID-MHP62>3.0.CO;2-1
Allison A Roberts Dr
<p><b>Background</b>: This study examines the impact of mental illness on the labor market performance of family members of afflicted individuals. Numerous research projects have attempted to measure the impact of mental illness and related disorders on the ill individual, yet have traditionally neglected estimating potential costs accruing to family members of the ill.<b>Aims of the Study</b>: Previous research estimating the impact of illness on the time allocation decisions of family caregivers has been limited in scope. I obtain estimates of the impact of mental illness on the probability of labor force participation and hours of work of all family members. The general analysis used in this study will pave the way for more accurate assessments of the costs of <i>all</i> types of illness and the estimates obtained will provide policy makers with a much more complete picture of the costs of mental illness.<b>Methods</b>: The main empirical work in this study includes a probit estimation of labor force participation and a tobit regression of hours worked (including sample selection correction). The data sample, taken from the 1987 National Medical Expenditure Survey, is also partitioned by gender to clarify effects of family illness on labor supply for both females and males.<b>Results</b>: Adult males are found to <i>increase</i> their probability of labor force participation in the presence of mental illness in the family (all else equal) when the mental illness is accompanied by a chronic physical illness. However, females are surprisingly found to have no significant impact on their probability of being a member of the labor market when a family member is afflicted with mental illness. On the other hand, hours of work are significantly <i>reduced</i> for both females and males when the mentally ill family member is afflicted with additional illnesses (physical and/or mental).<b>Discussion</b>: Previous studies have traditionally not considered the effects of family illness on males because females are typically found to be the primary caregiver when a family member falls ill. The findings in this study indicate that men suffer reductions in their hours of work in an equivalent magnitude to females. Thus, males should <i>not</i> be ignored when estimating the opportunity costs of illness in families.<b>Implications for Health Policies</b>: Current federal and state policies provide for some of the medical costs and replace some of the lost income of ill individuals, but generally do not support family members who are negatively affected by illness. This research provides evidence supporting the arguments of advocates for policy to ameliorate the financial burden borne by family members of the ill.<b>Implications for Future Research</b>: The estimates obtained in this study show that women and men both need to be studied when determining the effects of family illness on labor supply, and should be studied separately to obtain clear results. Al
背景:本研究考察了精神疾病对受影响个体家庭成员劳动力市场表现的影响。许多研究项目试图衡量精神疾病和相关障碍对患病个体的影响,但传统上忽略了估计患者家庭成员的潜在成本。研究目的:以前估计疾病对家庭护理人员时间分配决策影响的研究范围有限。我估计了精神疾病对劳动力参与概率和所有家庭成员工作时间的影响。这项研究中使用的一般分析将为更准确地评估所有类型疾病的成本铺平道路,所获得的估计将为决策者提供更全面的精神疾病成本信息。方法:本研究的主要实证工作包括劳动力参与度的probit估计和工作时间的tobit回归(包括样本选择校正)。数据样本取自1987年的全国医疗支出调查,也按性别划分,以阐明家庭疾病对女性和男性劳动力供应的影响。结果:当精神疾病伴有慢性身体疾病时,成年男性在家庭中出现精神疾病的情况下(其他情况相同)参与劳动力的概率会增加。然而,令人惊讶的是,当家庭成员患有精神疾病时,女性对成为劳动力市场成员的概率没有显著影响。另一方面,当精神病家庭成员患有其他疾病(身体和/或精神)时,女性和男性的工作时间都会显著减少。讨论:以前的研究传统上没有考虑家庭疾病对男性的影响,因为女性通常是家庭成员生病时的主要照顾者。这项研究的结果表明,男性的工作时间减少幅度与女性相当。因此,在估计家庭患病的机会成本时,不应忽视男性。对健康政策的影响:目前的联邦和州政策规定了部分医疗费用,并弥补了患者的部分收入损失,但通常不支持受疾病负面影响的家庭成员。这项研究提供了证据,支持倡导减轻患者家庭成员经济负担的政策的人的论点。对未来研究的启示:这项研究中获得的估计表明,在确定家庭疾病对劳动力供应的影响时,女性和男性都需要进行研究,并且应该分别进行研究以获得明确的结果。此外,未来的研究应该包括检查特定的精神疾病,看看其中一种疾病的成本是否高于另一种疾病(例如,精神分裂症与严重抑郁症),因为这可能会为决策者提供有价值的信息。此外,应将心理障碍的费用与慢性身体疾病(如癌症和心脏病)的费用进行比较。版权所有©1999 John Wiley&;有限公司。
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引用次数: 28
The mental health care delivery system in greece: regional variation and socioeconomic correlates 希腊的精神卫生保健提供系统:区域差异和社会经济相关性
IF 1.6 4区 医学 Q4 HEALTH POLICY & SERVICES Pub Date : 2000-05-31 DOI: 10.1002/(SICI)1099-176X(199912)2:4<169::AID-MHP65>3.0.CO;2-T
Michael G. Madianos, Costas Zacharakis, Chryssa Tsitsa, Costas Stefanis
<p><b>Background</b>: In Greece, the functional capacity of the mental health care system until 1980, was totally inadequate to meet the increasing mental health needs of the population and to provide efficient and community-based services. This situation was brought to the attention of the Commission of European Communities and a special EEC Regulation No 815/84 provided the financial technical support for an extended psychiatric reform programme. The psychiatric reform programme initiated in 1984 and ended in 1995.<b>Aims of the study</b>: This study compared the geographical distribution of neuropsychiatrists and the mental health care delivery system structural components (psychiatric beds, extramural mental health units and places in rehabilitation services), according to the regional socioeconomic development for the years 1984, 1990 and 1996. Additionally the possible effects of the operation of community-based mental health services on the psychiatric hospitalizations were examined.<b>Methods</b>: Data on the geographical distribution of neuropsychiatrists in the previously mentioned years were drawn from local Medical Association from each of 54 prefectures of the country. The corresponding distribution of the mental health care delivery system components was made available from the database of the Monitoring and Evaluation of Mental Health Services Unit. Pearson product moment correlations of the regional distribution of neuropsychiatrists and the various components of the mental health care system, as population-based ratios, with the corresponding socioeconomic development in the form of the general index of development were performed. Mental hospital age standardized rates were collected from the Hospital Central Register for the periods 1984–1987 and 1990–1993. Discharge rates were elaborated according to the existence of mental health services in specific regions.<b>Results</b>: A wide regional variation in neuropsychiatrists per 100000 population was found in all three years, with the majority of them working in the greater Athens and Thessaloniki areas. In the geographical distribution of health regions, there is an uneven significant decrease in psychiatric beds between 1984 and 1996. However in almost all regions an increase in extramural services between the two critical periods was noticed, as part of the implementation of the psychiatric reform programme. A parallel and more dramatic increase in the places of rehabilitation in 12 out of 13 regions has been observed during the implementation of the reform programme. At the level of prefectures, the changes across time, in the mean ratios of beds, extramural services and rehabilitation places were not found to be significant.</p><p>A significant decrease of discharges in prefectures covered by newly established extramural services for the period 1990–1993, compared to discharge rates during the period 1984–1987, when none of these services were in operation in these prefecture
背景:在希腊,直到1980年,精神卫生保健系统的功能能力完全不足以满足人口日益增长的精神卫生需求,也不足以提供高效的社区服务。这一情况已提请欧洲共同体委员会注意,欧洲经济共同体第815/84号特别条例为扩大精神病改革方案提供了财政技术支持。精神病改革方案始于1984年,结束于1995年。研究目的:本研究根据1984年的区域社会经济发展,比较了神经精神病学家的地理分布和精神卫生保健提供系统的结构组成部分(精神病病床、校外精神卫生单位和康复服务场所),1990年和1996年。此外,还考察了社区精神卫生服务的运作对精神病住院的可能影响。方法:前几年神经精神科医生的地理分布数据来自全国54个县的地方医学协会。心理健康服务监测和评估股的数据库提供了心理健康服务提供系统各组成部分的相应分布情况。对神经精神病学家的区域分布和精神卫生保健系统的各个组成部分(以人口为基础的比率)与相应的社会经济发展(以发展总指数的形式)进行了皮尔逊乘积矩相关性。1984年至1987年和1990年至1993年期间,精神病院年龄标准化率从医院中央登记处收集。出院率是根据特定地区是否有心理健康服务而制定的。结果:在所有三年中,每100000人口中的神经精神科医生存在广泛的地区差异,其中大多数在大雅典和塞萨洛尼基地区工作。从保健地区的地理分布来看,1984年至1996年期间,精神病病床的减少幅度不均衡。然而,作为实施精神病改革方案的一部分,几乎所有地区都注意到,在这两个关键时期,校外服务有所增加。在实施改革方案期间,观察到13个区域中有12个区域的康复场所同时大幅增加。在县一级,床位、校外服务和康复场所的平均比例随时间的变化并不显著。与1984年至1987年期间的排放率相比,1990年至1993年期间,新建立的校外服务覆盖的县的排放率显著下降,当时这些县没有这些服务。54个都道府县精神卫生保健系统各组成部分的各种平均值(1990-1996)与当地发展综合指数得分之间的相互关系矩阵产生了具有统计学意义的相关系数。似乎地方社会经济发展水平越高,心理卫生服务体系的发展程度就越高。讨论:我们的研究结果显示,尽管目前整个精神卫生保健提供系统进行了重组,但神经精神科医生、校外精神卫生单位和康复场所的区域分布不均衡。54个都道府县系统的各种结构组成部分与当地社会经济条件之间的正相关关系可以解释如下。社会经济增长率较高的城市地区在精神病院的住院服务方面有着悠久的发展历史。在这些方案中,已经建立了几个以社区为基础的替代方案,以便将其转变为现代方案。城市地区的精神病发病率也较高,因此对心理健康的需求也在增加。此外,在几个城市,当地大学精神科已经开发了各种心理健康和康复服务。在城市地区建立了许多与现有精神病院高度专业化和互补的新服务。农村地区大多没有精神卫生保健设施。然而,建立以社区为基础的服务似乎会对精神病院的利用率产生影响。结论:很明显,在希腊实施精神病改革方案后,在精神卫生和康复服务权力下放方面取得了重大进展。然而,许多都道府县仍有一些地区,主要是农村或半农村地区,缺乏适当的心理保健服务。 对医疗保健和政策制定的影响:我们的研究结果表明,应该引入灵活的服务模式,以造福生活在缺乏必要社会经济资源地区的人口。对未来研究的影响:希腊的心理健康服务研究应侧重于对不同社会经济增长地区的各种心理健康护理模式的有效性进行准实验研究。版权所有©1999 John Wiley&amp;有限公司。
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引用次数: 39
Identifying factors affecting the placement of mentally ill patients 确定影响精神病患者安置的因素
IF 1.6 4区 医学 Q4 HEALTH POLICY & SERVICES Pub Date : 2000-05-31 DOI: 10.1002/(SICI)1099-176X(199912)2:4<177::AID-MHP61>3.0.CO;2-3
Eamon O'Shea, Jenny Hughes, Siobhán O'Reilly

Background: There is now general agreement that a comprehensive psychiatric service can operate with the minimum use of in-patient facilities. Consequently, the emphasis in most European countries is on reducing the number of inpatient beds and expanding the range of community care facilities, including day hospital services, available to mentally ill patients. Decision-making with respect to placement is now even more important given the changes currently taking place on the supply side.Method: The study examines the factors that influence placement decision-making between inpatient care and day hospital care in one Health Board in Ireland. Placement was examined over a 9 month period for all patients presenting for treatment in one particular area with a population of 39000 people. Patients were not randomized between the two settings due to ethical concerns about the randomization process. The issue of placement is analysed using a logit estimation procedure.Results: The results suggest that two variables have a significant affect on placement for the population under review: whether the patient is accompanied at the time of admission and the domicile of the patient.Conclusions: Greater flexibility with respect to the opening hours of day hospital facilities, linked to improved transport facilities, together with further analysis on the process of admission to hospital, particularly the dynamics of the interaction between providers, patients, and accompanying persons, may improve placement decision-making for mentally ill patients. Copyright © 1999 John Wiley & Sons, Ltd.

背景:现在人们普遍认为,综合精神病服务可以在最低限度地使用住院设施的情况下运作。因此,大多数欧洲国家的重点是减少住院床位,扩大社区护理设施的范围,包括为精神病患者提供的日间医院服务。考虑到目前供应方面正在发生的变化,关于安置的决策现在更加重要。方法:在爱尔兰的一个卫生委员会中,研究了影响住院护理和日间医院护理之间安置决策的因素。在一个39000人的特定地区,对所有接受治疗的患者进行了为期9个月的安置检查。由于对随机化过程的伦理考虑,患者没有在两种设置之间进行随机化。使用logit估计程序分析了安置问题。结果:研究结果表明,有两个变量对受访人群的安置有显著影响:患者入院时是否有陪同以及患者的住所。结论:日间医院设施的开放时间有更大的灵活性,与改善的交通设施有关,再加上对入院过程的进一步分析,特别是提供者、患者和陪同人员之间互动的动态,可能会改善精神病患者的安置决策。版权所有©1999 John Wiley&;有限公司。
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引用次数: 0
Organizational determinants of psychosocial treatment activity of providers in Va mental health facilities 弗吉尼亚州精神卫生机构提供者心理社会治疗活动的组织决定因素
IF 1.6 4区 医学 Q4 HEALTH POLICY & SERVICES Pub Date : 2000-05-31 DOI: 10.1002/(SICI)1099-176X(199912)2:4<153::AID-MHP63>3.0.CO;2-7
Jeffrey A. Alexander, Joan R. Bloom, James L. Zazzali, Kimberly Jinnett

Objective: To identify the determinants of level and intensity of psychosocial treatment activity among staff who deliver services to the severely and mentally ill.Methods: The study sample consisted of 769 treatment providers working in 77 units in 29 VA mental health facilities. Level of psychosocial care was measured as the number of patient contacts and total hours spent in psychosocial care over a 1 week period. Intensity of psychosocial care was measured as the average time per patient contact. We used hierarchical linear modeling (HLM) to examine the association between level and intensity of care and three categories of determinants—individual provider attributes, work characteristics and treatment setting characteristics.Results: Providers' occupation is related to both the level and intensity of care. Providers with administrative responsibilities also have fewer patient contacts and lower intensity of such contacts. Providers who perceived their pay and benefits more positively had fewer patient contacts and less intensive patient contacts. Positive relationships with patients and providers were also associated with greater levels and intensity of psychosocial treatment activity among providers. Finally, statistically significant differences in psychosocial treatment activity among units were identified although such differences are not attributable to unit size, patient cohort severity or unit workload.Conclusions: Level and intensity of psychosocial treatment activity vary systematically by individual attributes of providers, characteristics of the work they perform and attributes of the treatment setting. These factors may provide the basis for designing interventions to modify provider behavior in a manner consistent with emerging financial pressures and treatment modalities for the seriously mentally ill. Copyright © 1999 John Wiley & Sons, Ltd.

目的:确定为重症和精神病患者提供服务的工作人员的心理社会治疗活动水平和强度的决定因素。心理社会护理水平衡量为一周内与患者接触的次数和在心理社会护理中花费的总时间。心理社会护理的强度被测量为每个患者接触的平均时间。我们使用分层线性模型(HLM)来检验护理水平和强度与三类决定因素之间的关系——个人提供者属性、工作特征和治疗环境特征。结果:提供者的职业与护理水平和强度有关。负有行政责任的提供者与患者的接触也较少,这种接触的强度也较低。对自己的薪酬和福利有更积极看法的提供者与患者的接触更少,与患者的密切接触也更少。与患者和提供者的积极关系也与提供者之间更高水平和强度的心理社会治疗活动有关。最后,确定了各单位之间心理社会治疗活动的统计学显著差异,尽管这种差异不是由于单位规模、患者队列严重程度或单位工作量造成的。结论:心理社会治疗活动的水平和强度因提供者的个人特征、他们所从事工作的特点和治疗环境的特点而有系统地变化。这些因素可能为设计干预措施提供基础,以改变提供者的行为,使其符合新出现的经济压力和严重精神病患者的治疗模式。版权所有©1999 John Wiley&;有限公司。
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引用次数: 1
Economic evaluation and mental health: sparse past . . . fertile future? 经济评估与心理健康:稀疏的过去。肥沃的未来?
IF 1.6 4区 医学 Q4 HEALTH POLICY & SERVICES Pub Date : 2000-05-31 DOI: 10.1002/(SICI)1099-176X(199912)2:4<163::AID-MHP64>3.0.CO;2-1
Martin Knapp
<p><b>Background</b>: Demands for economic inputs to mental health policy-making, practice decisions and research evaluations have grown considerably in recent years, but the overall supply response has been modest and uneven.<b>Aims</b>: This paper examines the key historical phases in the development of mental health economics research, and what they imply for the way economics is received and employed. Focusing on the quest for cost-effectiveness, the paper considers challenges for mental health economics.<b>Methods</b>: An informal review of the growing demand for mental health economics (and how that demand has been expressed), and how economists have responded.<b>Results</b>: Five historical development phases characterize this growth. Initially, the dominant feature is innocence or neglect of scarcity. Cost measures are rarely calculated, cost-effectiveness is not part of the decision-making lexicon and the potential for inefficiency is huge.</p><p>In the second phase, innocence turns to criticism of attempts to introduce resource rationality, and many clinicians actively reject economics. Health is seen as priceless, and not to be compromised by the pursuit of efficiency.</p><p>After a period of reluctance there follows impetuosity as the need for economic insights is recognized, but the search for data is desperate and undiscriminating. Poor quality research is conducted, with the risk that decisions are misinformed and perhaps damaging. Once again, resources are inappropriately used.</p><p>Next follows the constructive development phase: previous mistakes are appreciated and the standards of evaluation improve markedly. Studies are better designed, more likely to be integrated into clinical or policy evaluations, carefully conducted and sensibly interpreted. Inefficiency should be reduced, along with inequity.</p><p>Finally, there is perhaps a nirvana-like fifth phase in which sophisticated economic studies are widely undertaken, where systematic reviews and meta-analyses help to reveal the wider picture and where findings are readily available to clinicians, managers and providers. Whether such a stage is attainable is open to question.<b>Discussion</b>: Although the number and sophistication of economic evaluations have both increased noticeably over recent years, there remain imbalances. There is little economics evidence on care arrangements or treatments for dementia, most of the neuroses and the disorders of childhood and adolescence. There are many fewer good evaluations of psychological interventions than of drug treatments. Geographically, few economic evaluations are conducted outside Western Europe, North America or Australasia.<b>Implications for decision-makers and research</b>: Many challenges consequently face the next generation of mental health economics evaluations, both for research economists and for those health care decision-makers who find themselves increasingly having to draw on economics evidence. One challenge
背景:近年来,对心理健康政策制定、实践决策和研究评估的经济投入需求大幅增长,但总体供应反应温和且不均衡。目的:本文考察了心理健康经济学研究发展的关键历史阶段,以及它们对经济学的接受和运用方式意味着什么。本文着眼于追求成本效益,思考了心理健康经济学面临的挑战。方法:对心理健康经济学日益增长的需求(以及这种需求是如何表达的)以及经济学家的反应进行非正式审查。结果:这一增长经历了五个历史发展阶段。最初,主要特征是天真无邪或忽视稀缺性。很少计算成本指标,成本效益不在决策词汇中,效率低下的可能性很大。在第二阶段,清白转向了对引入资源理性的尝试的批评,许多临床医生积极拒绝经济学。健康被视为无价之宝,不能因追求效率而受损。在经历了一段时间的不情愿之后,随着对经济见解的需求得到认可,随之而来的是冲动,但对数据的搜索是绝望和无差别的。进行的研究质量很差,有决策被误导的风险,可能会造成损害。资源再次被不恰当地使用。接下来是建设性的发展阶段:对以前的错误表示赞赏,评估标准显著提高。研究设计得更好,更有可能纳入临床或政策评估,仔细进行并合理解释。应该减少效率低下和不公平现象。最后,也许还有一个类似涅盘的第五阶段,在这个阶段,复杂的经济研究被广泛进行,系统的审查和荟萃分析有助于揭示更广泛的情况,临床医生、管理人员和提供者可以随时获得研究结果。这样一个阶段是否能够实现还有待商榷。讨论:尽管近年来经济评估的数量和复杂程度都显著增加,但仍存在不平衡。关于痴呆症、大多数神经症以及儿童和青少年的疾病的护理安排或治疗,几乎没有经济学证据。与药物治疗相比,对心理干预的良好评价要少得多。从地理位置来看,在西欧、北美或澳大拉西亚以外很少进行经济评估。对决策者和研究的影响:因此,下一代心理健康经济学评估面临着许多挑战,无论是对研究经济学家还是那些发现自己越来越需要利用经济学证据的医疗保健决策者来说。一个挑战是要充分意识到,经济学家目前所能提供的信息可能达不到决策者的需求。必须充分认识到两者之间的差距。对不同护理政策和治疗干预措施的成本和结果后果建立更全面的了解是弥合这一差距的一种方法。与此同时,必须保持和促进一种视角感。例如,全世界都越来越担心新药的高价格,但药品采购成本通常只占总成本的一小部分。决策有时似乎不成比例地集中在整体心理健康护理的一小部分。类似的趋势引发了另一个挑战,即开展和解释研究,以克服或至少不加剧许多精神卫生保健系统的多服务、多机构现实所特有的边界问题。鉴于许多心理健康问题的长期性及其外部性影响(包括问题的代际传播),必须质疑短期评估的充分性。短期评估在我们的领域占据主导地位。尽管资金总是一个问题,但需要更长期的证据。研究个体间成本和结果差异的原因也是如此。经济评价还应更多地注意公平和效率,以此作为改进资源分配的标准。最后,应该在临床数据的同时而不是在临床数据之后收集更多的经济数据,特别是因为经济假设往往会推动关键的实践和政策变化。版权所有©1999 John Wiley&;有限公司。
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引用次数: 28
Antidepressant treatment for depression: total charges and therapy duration† 抑郁症的抗抑郁治疗:总费用和治疗持续时间†
IF 1.6 4区 医学 Q4 HEALTH POLICY & SERVICES Pub Date : 2000-01-01 DOI: 10.1002/mhp.95
Deborah G. Dobrez, Catherine A. Melfi, Thomas W. Croghan, Professor Thomas J. Kniesner, Robert L. Obenchain
BACKGROUND: The economic costs of depression are significant, both the direct medical costs of care and the indirect costs of lost productivity. Empirical studies of antidepressant cost-effectiveness suggest that the use of selective serotonin reuptake inhibitors (SSRIs) may be no more costly than tricyclic antidepressants (TCAs), will improve tolerability, and is associated with longer therapy duration. However the success of depression care usually involves multiple factors, including source of care, type of care, and patient characteristics, in addition to drug choice. The cost-effective mix of antidepressant therapy components is unclear. AIMS OF THE STUDY: Our study evaluates cost and antidepressant-continuity outcomes for depressed patients receiving antidepressant therapy. Specifically, we determined the impact of provider choice for initial care, concurrent psychotherapy, and choice of SSRI versus TCA-based pharmacotherapies on the joint outcome of low treatment cost and continuous antidepressant therapy. METHODS: A database of private health insurance claims identifies 2678 patients who received both a diagnosis of depression and a prescription for an antidepressant during 1990-1994. Patients each fall into one of four groups according to whether their health care charges are high versus low (using the median value as the break point) and by whether their antidepressant usage pattern is continuous versus having discontinued pharmacotherapy early (filling fewer than six prescriptions). A bivariate probit model controlling for patient characteristics, co-morbidities, type of depression and concurrent treatment is the primary multivariate statistical vehicle for the cost-effective treatment situation. RESULTS: SSRIs substantially reduce the incidence of patients discontinuing pharmacotherapy while leaving charges largely unchanged. The relative effectiveness of SSRIs in depression treatment is independent of the patient's personal characteristics and dominates the consequences of other treatment dimensions such as seeing a mental health specialist and receiving concurrent psychotherapy. Initial provider specialty is irrelevant to the continuity of pharmacotherapy, and concurrent psychotherapy creates a tradeoff through reduced pharmacotherapy interruption with higher costs. DISCUSSION: Longer therapy duration is associated with SSRI-based pharmacotherapy (relative to TCA-based pharmacotherapy) and with concurrent psychotherapy. High cost is associated with concurrent psychotherapy and choice of a specialty provider for initial care. In our study cost-effective care includes SSRI-based pharmacotherapy initiated with a non-specialty provider. Previous treatment history and other unobserved factors that might affect antidepressant choice are not included in our model. IMPLICATIONS FOR HEALTH CARE PROVISION: The decision to use an SSRI-based pharmacotherapy need not consider carefully the patient's personal characteristics. Shifting depressed p
背景:抑郁症的经济成本是巨大的,包括护理的直接医疗成本和生产力损失的间接成本。抗抑郁药成本效益的实证研究表明,选择性血清素再摄取抑制剂(SSRIs)的使用成本可能不比三环类抗抑郁药(TCAs)高,将提高耐受性,并与更长的治疗时间有关。然而,抑郁症护理的成功通常涉及多种因素,包括护理来源、护理类型和患者特征,以及药物选择。抗抑郁治疗成分的成本效益组合尚不清楚。研究目的:我们的研究评估了接受抗抑郁治疗的抑郁症患者的成本和抗抑郁持续性结果。具体而言,我们确定了初始护理的提供者选择、同时进行的心理治疗以及SSRI与TCA药物治疗的选择对低治疗成本和持续抗抑郁治疗的联合结果的影响。方法:一个私人健康保险索赔数据库确定了2678名患者,他们在1990-1994年间接受了抑郁症诊断和抗抑郁药处方。根据他们的医疗费用是高还是低(以中值为分界点),以及他们的抗抑郁药使用模式是持续的还是提前停止药物治疗(开具少于六张处方),每个患者分为四组。控制患者特征、合并症、抑郁类型和同时治疗的双变量probit模型是成本效益治疗情况的主要多变量统计工具。结果:SSRIs显著降低了患者停止药物治疗的发生率,同时基本上保持费用不变。SSRIs在抑郁症治疗中的相对有效性独立于患者的个人特征,并主导其他治疗维度的后果,如看心理健康专家和同时接受心理治疗。最初的提供者专业与药物治疗的连续性无关,同时进行的心理治疗通过减少药物治疗中断和提高成本来创造一种权衡。讨论:较长的治疗时间与基于SSRI的药物治疗(相对于基于TCA的药物治疗)和同时进行的心理治疗有关。高昂的费用与同时进行心理治疗和选择专业提供者进行初始护理有关。在我们的研究中,成本效益高的护理包括由非专业提供者发起的基于SSRI的药物治疗。我们的模型中没有包括既往治疗史和其他可能影响抗抑郁药选择的未观察到的因素。对医疗保健的影响:决定使用基于SSRI的药物治疗不需要仔细考虑患者的个人特征。将抑郁症患者的药物治疗从TCAs转移到SSRIs,可以通过降低药物治疗中断的发生率来改善结果,同时在很大程度上保持高整体医疗费用的可能性不变。有针对性地同时使用心理治疗可能具有额外的成本效益。对健康政策的影响:抑郁症护理的各个组成部分的相互作用可以改变抗抑郁治疗的成本效益。我们的研究结果表明,非专业提供者在启动护理和支持增加SSRIs作为抑郁症一线治疗的使用方面发挥了作用,这是一种提供符合APA持续抗抑郁治疗指南的成本效益护理的方式。进一步研究的意义:进一步的研究提高了我们对提供者选择、同时进行心理治疗和药物选择的决策的理解,将提高我们对治疗选择对抑郁症护理成本效益的影响的理解。我们已经提出,有针对性的同时进行心理治疗可能被证明是具有成本效益的;确定最有可能从额外治疗中受益的群体的研究将进一步使临床医生和医疗保健政策制定者能够就抑郁症的治疗模式达成共识。版权所有©2000 John Wiley&;有限公司。
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引用次数: 9
Rational decision-making in mental health: the role of systematic reviews 心理健康中的理性决策:系统评价的作用
IF 1.6 4区 医学 Q4 HEALTH POLICY & SERVICES Pub Date : 1999-12-24 DOI: 10.1002/(SICI)1099-176X(199909)2:3<99::AID-MHP51>3.0.CO;2-C
Simon M Gilbody, Mark Petticrew
<p>Background: ‘Systematic reviews’ have come to be recognized as the most rigorous method of summarizing confusing and often contradictory primary research in a transparent and reproducible manner. Their greatest impact has been in the summarization of epidemiological literature—particularly that relating to clinical effectiveness. Systematic reviews also have a potential to inform rational decision-making in healthcare policy and to form a component of economic evaluation. Aims of the study: This article aims to introduce the rationale behind systematic reviews and, using examples from mental health, to introduce the strengths and limitations of systematic reviews, particularly in informing mental health policy and economic evaluation. Methods: Examples are selected from recent controversies surrounding the introduction of new psychiatric drugs (anti-depressants and anti-schizophrenia drugs) and methods of delivering psychiatric care in the community (case management and assertive community treatment). The potential for systematic reviews to (i) produce best estimates of clinical efficacy and effectiveness, (ii) aid economic evaluation and policy decision-making and (iii) highlight gaps in the primary research knowledge base are discussed. Lastly examples are selected from outside mental health to show how systematic reviews have a potential to be explicitly used in economic and health policy evaluation. Results: Systematic reviews produce the best estimates of clinical efficacy, which can form an important component of economic evaluation. Importantly, serious methodological flaws and areas of uncertainty in the primary research literature are identified within an explicit framework. Summary indices of clinical effectiveness can be produced, but it is difficult to produce such summary indices of cost effectiveness by pooling economic data from primary studies. Modelling is commonly used in economic and policy evaluation. Here, systematic reviews can provide the best estimates of effectiveness and, importantly, highlight areas of uncertainty that can be used in ‘sensitivity analysis’. Discussion: Systematic reviews are an important recent methodological advance, the potential for which has only begun to be realized in mental health. This use of systematic reviews is probably most advanced in producing critical summaries of clinical effectiveness data. Systematic reviews cannot produce valid and believable conclusions when the primary research literature is of poor quality. An important function of systematic reviews will be in highlighting this poor quality research which is of little use in mental health decision making. Implications for health provision: Health care provision should be both clinically and cost effective. Systematic reviews are a key component in ensuring that this goal is achieved. Implications for health policies: Systematic reviews have potential to inform health policy. Examples presented show that health policy is often m
背景:“系统综述”已被公认为以透明和可重复的方式总结令人困惑且往往相互矛盾的初级研究的最严格方法。他们最大的影响是对流行病学文献的总结,尤其是与临床有效性有关的文献。系统审查也有可能为医疗政策的理性决策提供信息,并成为经济评估的一个组成部分。研究目的:本文旨在介绍系统综述背后的基本原理,并利用心理健康的例子,介绍系统综述的优势和局限性,特别是在为心理健康政策和经济评估提供信息方面。方法:从最近围绕引入新的精神病药物(抗抑郁药和抗精神分裂症药物)和在社区提供精神病护理的方法(病例管理和果断的社区治疗)的争议中选择例子。讨论了系统审查的潜力,以(i)产生临床疗效和有效性的最佳估计,(ii)帮助经济评估和政策决策,以及(iii)突出初级研究知识库中的差距。最后,从外部心理健康中选择了一些例子,以表明系统审查如何有潜力明确用于经济和卫生政策评估。结果:系统评价产生了对临床疗效的最佳估计,这可以成为经济评价的重要组成部分。重要的是,主要研究文献中的严重方法论缺陷和不确定性领域是在明确的框架内确定的。可以产生临床有效性的汇总指数,但很难通过汇集初级研究的经济数据来产生这种成本效益的汇总指数。建模通常用于经济和政策评估。在这里,系统审查可以提供对有效性的最佳估计,重要的是,可以突出可用于“敏感性分析”的不确定性领域。讨论:系统综述是最近方法学的一个重要进展,其潜力在心理健康方面才刚刚开始实现。这种系统综述的使用可能在产生临床有效性数据的关键摘要方面是最先进的。当主要研究文献质量较差时,系统综述无法得出有效可信的结论。系统综述的一个重要功能是突出这项质量较差的研究,这项研究在心理健康决策中几乎没有用处。对医疗服务的影响:医疗服务应具有临床和成本效益。系统审查是确保实现这一目标的关键组成部分。对卫生政策的影响:系统审查有可能为卫生政策提供信息。所举的例子表明,制定卫生政策往往没有适当考虑研究证据。系统的审查可以提供有力和可信的答案,有助于为理性决策提供信息。重要的是,系统的审查可以突出重要的初级研究的必要性,并可以为这项研究的设计提供信息,从而提供有助于制定医疗保健政策的答案。对进一步研究的启示:系统的审查应该先于昂贵的(通常是不必要的)初级研究。卫生政策和实践的许多领域尚未使用系统的审查方法进行评估。经济数据汇总的方法在方法论上很复杂,值得进一步研究。版权所有©1999 John Wiley&;有限公司。
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引用次数: 25
Costs of drug abuse to society 吸毒给社会带来的代价
IF 1.6 4区 医学 Q4 HEALTH POLICY & SERVICES Pub Date : 1999-12-24 DOI: 10.1002/(SICI)1099-176X(199909)2:3<133::AID-MHP53>3.0.CO;2-B
William S. Cartwright

Background: The costs of substance abuse in the USA are enormous and varied. Seldom are they comprehensively assessed. A new study jointly published by the National Institute on Drug Abuse (NIDA) and the National Institute on Alcoholism and Alcohol Abuse (NIAAA) has done just this. Aims: Researchers for the economic cost of alcohol and drug abuse in the United States, 1992 used systematic cost-of-illness measurement methods to evaluate the burden drug abuse and dependency place on the US economy. This burden includes widespread disability, morbidity, premature death, and diversion of economic resources to drug-related activities. Conceptualizing, identifying, and measuring this burden was a major undertaking; the report describes the methods in detail. Method: Costs are measured as the value of resources used (direct costs) or lost during a one year period. As adopted here, the human capital approach estimates an individual’s value to society in terms of his or her production potential. The value of future lost earnings is discounted to present time. Finally, the study adopts a societal point of view that is consistent with the recommendations of the Panel on Cost-Effectiveness in Health and Medicine that was convened by the U.S. Public Health Service in 1993. Therefore, this study considers all health and non-health outcomes and costs created by drug abuse and dependency for the entire population. Results: For drug abuse, the annual cost in 1992 is estimated at $98 billion. By 1995, this estimate rose to $110 billion after adjusting for inflation and population change. For 1988, a previous and similar study estimated a cost of $58 billion. The distribution of costs is of particular concern.

背景:在美国,药物滥用的代价是巨大而多样的。很少对它们进行全面评估。美国国家药物滥用研究所(NIDA)和美国国家酗酒和酗酒研究所(NIAAA)联合发表的一项新研究正是这样做的。目的:研究美国酒精和药物滥用的经济成本的研究人员,1992年使用系统的疾病成本测量方法来评估药物滥用和依赖对美国经济的负担。这一负担包括广泛的残疾、发病率、过早死亡以及将经济资源用于与毒品有关的活动。概念化、识别和衡量这一负担是一项重大任务;报告详细描述了这些方法。方法:成本以一年内使用或损失的资源价值(直接成本)计量。正如这里所采用的,人力资本方法根据个人的生产潜力来估计个人对社会的价值。未来损失收益的价值折现为当前时间。最后,该研究采用了一种社会观点,该观点与美国公共卫生服务局于1993年召开的健康与医学成本效益小组的建议一致。因此,本研究考虑了整个人群因药物滥用和依赖而产生的所有健康和非健康结果以及成本。结果:在药物滥用方面,一九九二年每年的费用估计为980亿元。到1995年,经通货膨胀和人口变化调整后,这一估计数上升到1100亿美元。在1988年,之前的一项类似研究估计花费了580亿美元。费用的分配尤其令人关切。
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引用次数: 36
Measuring costs of guideline-driven mental health care: the Texas Medication Algorithm Project 衡量指南驱动的心理健康护理的成本:德克萨斯州药物算法项目
IF 1.6 4区 医学 Q4 HEALTH POLICY & SERVICES Pub Date : 1999-12-24 DOI: 10.1002/(SICI)1099-176X(199909)2:3<111::AID-MHP52>3.0.CO;2-M
T. Michael Kashner, A. John Rush, Kenneth Z. Altshuler

Background: Algorithms describe clinical choices to treat a specific disorder. To many, algorithms serve as important tools helping practitioners make informed choices about how best to treat patients, achieving better outcomes more quickly and at a lower cost. Appearing as flow charts and decision trees, algorithms are developed during consensus conferences by leading experts who explore the latest scientific evidence to describe optimal treatment for each disorder. Despite a focus on ‘optimal’ care, there has been little discussion in the literature concerning how costs should be defined and measured in the context of algorithm-based practices. Aims of the study: This paper describes the strategy to measure costs for the Texas Medication Algorithm project, or TMAP. Launched by the Texas Department of Mental Health and Mental Retardation and the University of Texas Southwestern Medical Center at Dallas, this multi-site study investigates outcomes and costs of medication algorithms for bipolar disorder, schizophrenia and depression. Methods: To balance costs with outcomes, we turned to cost-effectiveness analyses as a framework to define and measure costs. Alternative strategies (cost–benefit, cost–utility, cost-of-illness) were inappropriate since algorithms are not intended to guide resource allocation across different diseases or between health- and non-health-related commodities. ‘Costs’ are operationalized consistent with the framework presented by the United States Public Health Service Panel on Cost Effectiveness in Medicine.

Patient specific costs are calculated by multiplying patient units of use by a unit cost, and summing over all service categories. Outpatient services are counted by procedures. Inpatient services are counted by days classified into diagnosis groups. Utilization information is derived from patient self-reports, medical charts and administrative file sources. Unit costs are computed by payer source. Finally, hierarchical modeling is used to describe how costs and effectiveness differ between algorithm-based and treatment-as-usual practices. Discussion: Cost estimates of algorithm-based practices should (i) measure opportunity costs, (ii) employ structured data collection methods, (iii) profile patient use of both mental health and general medical providers and (iv) reflect costs by payer status in different economic environments. Implication for health care provision and use: Algorithms may help guide clinicians, their patients and third party payers to rely on the latest scientific evidence to make treatment choices that balance costs with outcomes. Implication for health policies: Planners should consider consumer wants and economic costs when developing and testing new clinical algorithms. Implications for further research: Future studies may wish to consider similar methods to estimate costs in evaluating algorithm-based practices. Copyright © 1999 John Wiley & Sons, Ltd.

背景:算法描述了治疗特定疾病的临床选择。对许多人来说,算法是重要的工具,可以帮助从业者在知情的情况下选择如何最好地治疗患者,更快、更低地获得更好的结果。算法以流程图和决策树的形式出现,由领先的专家在共识会议上开发,他们探索最新的科学证据来描述每种疾病的最佳治疗方法。尽管关注“最佳”护理,但文献中很少讨论如何在基于算法的实践中定义和衡量成本。研究目的:本文描述了德克萨斯州药物算法项目(TMAP)的成本衡量策略。这项由得克萨斯州心理健康和智力迟钝部和达拉斯得克萨斯大学西南医学中心发起的多站点研究调查了双相情感障碍、精神分裂症和抑郁症药物算法的结果和成本。方法:为了平衡成本与结果,我们将成本效益分析作为定义和衡量成本的框架。替代策略(成本效益、成本效用、疾病成本)是不合适的,因为算法不旨在指导不同疾病之间或健康和非健康相关商品之间的资源分配。”成本”与美国公共卫生服务医学成本效益小组提出的框架一致。患者特定成本是通过将患者使用单位乘以单位成本,并对所有服务类别进行汇总来计算的。门诊服务按程序计算。住院服务按天计算,分为诊断组。利用率信息来源于患者自我报告、病历和管理文件来源。单位成本由付款人来源计算。最后,使用分层建模来描述基于算法和按惯例处理之间的成本和有效性如何不同。讨论:基于算法的实践的成本估计应(i)衡量机会成本,(ii)采用结构化数据收集方法,(iii)描述患者对心理健康和普通医疗服务提供者的使用情况,以及(iv)反映不同经济环境中按支付者身份划分的成本。对医疗保健提供和使用的影响:算法可能有助于指导临床医生、患者和第三方支付者依靠最新的科学证据来做出平衡成本与结果的治疗选择。卫生政策的含义:规划者在开发和测试新的临床算法时,应考虑消费者的需求和经济成本。对进一步研究的启示:未来的研究可能希望在评估基于算法的实践时考虑类似的方法来估计成本。版权所有©1999 John Wiley&;有限公司。
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引用次数: 29
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