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Hypertension Canada’s 2016 Canadian Hypertension Education Program guidelines for pharmacists 高血压加拿大2016年加拿大高血压教育计划药剂师指南
IF 1.5 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2016-10-06 DOI: 10.1177/1715163516671747
Yazid N. Al Hamarneh, S. Houle, R. Padwal, R. Tsuyuki
The Canadian Hypertension Education Program (CHEP) has been preparing and publishing guidelines for diagnosis and management of hypertension since 1999.1 The 2016 guidelines,2 released earlier this year, mark the 18th yearly production and update of evidence to date in the area of hypertension. Those guidelines, among other Hypertension Canada activities, can be considered as major contributors to the high levels of awareness and control of hypertension in Canada.3,4 Indeed, it has been reported that Canada has higher levels of awareness, treatment and control and lower prevalence of hypertension when compared with the United States and England.3
自1999年以来,加拿大高血压教育计划(CHEP)一直在编制和发布高血压诊断和管理指南。今年早些时候发布的2016年指南2标志着高血压领域迄今为止第18次年度证据编制和更新。这些指南,以及其他高血压加拿大活动,可以被认为是加拿大高血压意识和控制水平较高的主要贡献者。事实上,有报道称,与美国和英国相比,加拿大的高血压意识、治疗和控制水平较高,高血压患病率较低
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引用次数: 7
Are selective serotonin reuptake inhibitors associated with fractures? 选择性血清素再摄取抑制剂与骨折有关吗?
IF 1.5 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2016-10-06 DOI: 10.1177/1715163516671744
Sarah Drost, A. Massicotte
Antidepressant use in North America is on the rise. From 2007 to 2011, antidepressants were the most commonly used medication class by Canadian women aged 25 to 79 years and among the top 5 classes of drugs used by men aged 25 to 64 years.1 Selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, paroxetine, sertraline) are one of the most widely used classes of antidepressants because of their efficacy, favourable side effect profile and broad indications for use.2 In the past decade, more attention has been paid to the adverse effects of medications on bone health. Glucocorticoids, aromatase inhibitors (e.g., anastrazole, letrozole, exemestane), thiazolidinediones or “glitazones” (e.g., pioglitazone) and proton pump inhibitors (e.g., pantoprazole, omeprazole), among others, are suspected contributors to fractures.3 There is evidence indicating that SSRIs may also be implicated.3 In patients aged 66 years and older, current exposure to SSRIs has been associated with hip fractures compared with no antidepressant exposure (adjusted odds ratio [aOR]; 2.4; 95% CI: 2.0-2.7).4 One-third of women and one-fifth of men in Canada will experience an osteoporotic fracture during their lifetime. In 2010, osteoporosis and fractures cost the Canadian health care system upwards of 2.3 billion dollars.5 Fractures can cause a loss of long-term mobility and increase the risk of institutionalization. A prospective observational cohort of older adults showed that 12 months after a hip fracture, only half of patients regained their prefracture mobility level and only one-third of those who were previously mobile without an aid regained full mobility.6 A Canadian cohort (2001-2006) revealed that 12 months after a hip fracture, 24% of adults aged 75 years and older who were previously living in the community required institutionalization.7 However, that risk was much lower in patients aged 60 to 74 years, in whom only 14% of men and 4% of women required a transfer to a long-term care institution.7 Fractures are also associated with mortality, with 28% of women and 37% of men who experience a hip fracture dying within a year.5 It is therefore increasingly important to quantify the association between SSRIs and bone health. This review will discuss the current evidence that explores their association with an increased fracture risk.
抗抑郁药的使用在北美呈上升趋势。从2007年到2011年,抗抑郁药是加拿大25岁至79岁女性最常用的药物类别,也是25岁至64岁男性使用的前5类药物之一选择性血清素再摄取抑制剂;例如,西酞普兰,帕罗西汀,舍曲林)是使用最广泛的一类抗抑郁药,因为它们的疗效,良好的副作用和广泛的适应症在过去的十年中,人们越来越关注药物对骨骼健康的不良影响。糖皮质激素、芳香化酶抑制剂(如阿那曲唑、来曲唑、依西美坦)、噻唑烷二酮或“格列酮”(如吡格列酮)和质子泵抑制剂(如泮托拉唑、奥美拉唑)等被怀疑是导致骨折的原因有证据表明,ssri类药物也可能与此有关在66岁及以上的患者中,与未服用抗抑郁药的患者相比,目前服用SSRIs与髋部骨折相关(调整优势比[aOR];2.4;95% ci: 2.0-2.7)加拿大三分之一的女性和五分之一的男性在他们的一生中会经历骨质疏松性骨折。2010年,骨质疏松症和骨折花费了加拿大医疗保健系统超过23亿美元骨折可导致长期活动能力丧失,并增加住院的风险。一项对老年人的前瞻性观察队列显示,髋部骨折12个月后,只有一半的患者恢复了骨折前的活动水平,只有三分之一的患者在没有辅助的情况下恢复了完全的活动能力加拿大的一项队列研究(2001-2006)显示,髋部骨折后12个月,24%的75岁及以上的老年人以前住在社区,需要住院治疗然而,在60至74岁的患者中,这种风险要低得多,其中只有14%的男性和4%的女性需要转移到长期护理机构骨折也与死亡率有关,经历过髋部骨折的女性和男性分别有28%和37%在一年内死亡因此,量化SSRIs与骨骼健康之间的关系变得越来越重要。这篇综述将讨论目前的证据,探讨它们与骨折风险增加的关系。
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引用次数: 1
Barriers to pharmacy practice change 药房实践的障碍改变了
IF 1.5 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2016-10-06 DOI: 10.1177/1715163516672832
Meagen M Rosenthal, Z. Austin, R. Tsuyuki
The practice of pharmacy has seen major changes in the past decade. Today, pharmacists from coast to coast can extend prescriptions and make therapeutic substitutions. Many pharmacists can also provide influenza vaccinations and in some cases initiate drug therapies (i.e., prescribe). However, it has also been well established that the integration of many of these services by pharmacists into practice has been slow and incomplete. As pharmacy regulatory and advocacy groups continue to push for pharmacists’ larger role within the health care system, these efforts are hampered by the lack of widespread adoption and integration of these services within practice. Therefore, we need to more carefully consider why pharmacy practice change has been so challenging. In 2010, we wrote a commentary titled “Are Pharmacists the Ultimate Barrier to Pharmacy Practice Change?” In that article, we suggested that pharmacists’ personality traits, including lack of confidence, fear of new responsibility, paralysis in the face of ambiguity, need for approval and risk aversion, were the heretofore unspoken barriers to practice change. Using this commentary as a starting point, the purpose of this editorial is to discuss the issue of whether it is our innate personality traits (“nature”) or our professional pharmacy culture (“nurture”) that holds us back.
在过去的十年里,药学的实践经历了重大的变化。今天,药剂师从东海岸到西海岸可以延长处方和治疗替代。许多药剂师还可以提供流感疫苗接种,并在某些情况下启动药物治疗(即开处方)。然而,也已确定,药剂师将许多这些服务纳入实践是缓慢和不完整的。由于药房监管和倡导团体继续推动药剂师在卫生保健系统中发挥更大的作用,这些努力受到实践中缺乏广泛采用和整合这些服务的阻碍。因此,我们需要更仔细地考虑为什么药房实践变化如此具有挑战性。2010年,我们写了一篇评论,题为“药剂师是药房实践变革的终极障碍吗?”在那篇文章中,我们提出,药剂师的人格特质,包括缺乏自信、害怕新的责任、面对模棱两可时的麻痹、需要批准和风险厌恶,是迄今为止实践变革的潜障碍。以这篇评论为出发点,这篇社论的目的是讨论是我们天生的性格特征(“天性”)还是我们的专业药学文化(“培养”)阻碍了我们的发展。
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引用次数: 22
Evaluation of a continuous quality improvement program in anticoagulant therapy 抗凝治疗持续质量改进方案的评价
IF 1.5 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2016-10-06 DOI: 10.1177/1715163516671334
Ariane Cantin, Alexandre Lahaie, Bojan Odobasic, Marie-Philip Tremblay, Dana Wazzan, Stéphanie Caron, C. Leblanc, J. Martineau, L. Lalonde
Background: The ACO Program (Programme ACO), a continuous quality improvement program (CQIP) in anticoagulation therapy, was offered in community pharmacies as a pilot project. Objective: To evaluate the participants’ appreciation for the various activities of the program. Methods: Participants had access to training activities, including an audit with feedback, online training activities (OTA), clinical tools and support from facilitators. Cognitive behavioural learning determinants were evaluated before and 5 months after the beginning of the program. Participants’ satisfaction and perception were documented via online questionnaires and a semistructured interview. Results: Of the 52 pharmacists in the ACO Program, 47 participated in this evaluation. Seventy-seven percent of the participants completed at least 1 OTA and 6% published on the forum. The feeling of personal effectiveness rose from 8.01 (7.67-8.35) to 8.62 (8.24-8.99). The audit and feedback, as well as the high-quality OTA and their lecturers, were the most appreciated elements. Discussion: There was a high OTA participation rate. The facilitators seemed to play a key role in the CQIP. The low level of participation in the forum reflects the known phenomenon of social loafing. Technical difficulties affecting the platform and data collection for the audit with feedback constituted limitations. Conclusion: The CQIP in anticoagulation therapy is appreciated by community pharmacists and is associated with an improved feeling of personal effectiveness.
背景:在社区药房开展了抗凝治疗持续质量改进项目(CQIP)。目的:评估参与者对项目各项活动的欣赏程度。方法:参与者可以参加培训活动,包括有反馈的审核、在线培训活动(OTA)、临床工具和辅导员的支持。认知行为学习决定因素在项目开始前和5个月后进行评估。参与者的满意度和感知是通过在线问卷和半结构化访谈记录的。结果:在ACO项目的52名药师中,有47名参加了本次评估。77%的参与者至少完成了一次OTA, 6%的参与者在论坛上发表了文章。个人效能感由8.01(7.67-8.35)上升至8.62(8.24-8.99)。审计和反馈,以及高质量的在线旅行社和他们的讲师,是最受欢迎的因素。讨论:OTA的参与率很高。促进者似乎在CQIP中发挥了关键作用。参与论坛的低水平反映了众所周知的社会惰化现象。影响平台的技术困难和反馈审计的数据收集构成了限制。结论:CQIP在抗凝治疗中得到了社区药师的认可,并与个人效能感的提高有关。
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引用次数: 3
Fitting naloxone into community pharmacy practice 纳洛酮在社区药学实践中的应用
IF 1.5 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2016-10-06 DOI: 10.1177/1715163516671968
K. Grindrod, M. Beazely
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引用次数: 2
Pay-for-performance remuneration for pharmacist prescribers’ management of hypertension 处方药师管理高血压的绩效薪酬
IF 1.5 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2016-10-03 DOI: 10.1177/1715163516671745
S. Houle, T. Charrois, F. McAlister, M. Kolber, Meagen M Rosenthal, R. Lewanczuk, N. Campbell, R. Tsuyuki
Background: To be sustainable, pharmacists providing direct patient care must receive appropriate payment for these services. This prespecified substudy of the RxACTION trial (a randomized trial of pharmacist prescribing vs usual care in patients with above-target blood pressure [BP]) aimed to determine if BP reduction achieved differed between patients whose pharmacist was paid by pay-for-performance (P4P) vs fee-for-service (FFS). Methods: Within RxACTION, patients with elevated BP assigned to the pharmacist prescribing group were further randomized to P4P or FFS payment for the pharmacist. In FFS, pharmacists received $150 for the initial visit and $75 for follow-up visits. P4P included FFS payments plus incentives of $125 and $250 for each patient who reached 50% and 100% of the BP target, respectively. The primary outcome was difference in change in systolic BP between P4P and FFS groups. Results: A total of 89 patients were randomized to P4P and 92 to the FFS group. Patients’ average (SD) age was 63.0 (13.2) years, 49% were male and 76% were on antihypertensive drug therapy at baseline, taking a median of 2 (interquartile range = 1) medications. Mean systolic BP reductions in the P4P and FFS groups were 19.7 (SD = 18.4) vs 17.0 (SD = 16.4) mmHg, respectively (p = 0.47 for the comparison of deltas and p = 0.29 after multivariate adjustment). Conclusions: This trial of pharmacist prescribing found substantial reductions in systolic BP among poorly controlled hypertensive individuals but with no appreciable difference when pharmacists were paid by P4P vs FFS.
背景:为了可持续发展,药剂师提供直接病人护理必须得到适当的支付这些服务。这项预先指定的RxACTION试验(一项针对血压高于目标[BP]患者的药剂师处方与常规护理的随机试验)的子研究旨在确定采用按绩效付费(P4P)和按服务付费(FFS)方式支付药剂师报酬的患者的降压效果是否不同。方法:在RxACTION中,分配到药剂师处方组的血压升高患者进一步随机分配到药剂师P4P或FFS支付组。在FFS中,药剂师首次就诊可获得150美元,随访可获得75美元。P4P包括对每位达到50%和100%血压目标的患者分别给予125美元和250美元的奖励。主要结局是P4P组和FFS组之间收缩压变化的差异。结果:89例患者随机分为P4P组,92例患者随机分为FFS组。患者平均(SD)年龄为63.0(13.2)岁,49%为男性,76%基线时正在接受降压药物治疗,中位数为2种(四分位数间距= 1)。P4P组和FFS组的平均收缩压降低分别为19.7 (SD = 18.4)和17.0 (SD = 16.4) mmHg (δ值比较p = 0.47,多因素调整后p = 0.29)。结论:药师处方试验发现,控制不佳的高血压患者收缩压明显降低,但药师使用P4P与FFS支付时,收缩压无明显差异。
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引用次数: 10
Tighter regulations needed for over-the-counter codeine in Canada 加拿大需要加强对非处方可待因的监管
IF 1.5 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2016-08-10 DOI: 10.1177/1715163516660572
J. Mackinnon
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引用次数: 12
Uptake of the MedsCheck annual medication review service in Ontario community pharmacies between 2007 and 2013 2007年至2013年安大略省社区药房MedsCheck年度药物审查服务的使用情况
IF 1.5 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2016-08-09 DOI: 10.1177/1715163516662670
L. Dolovich, Giulia P. Consiglio, L. Mackeigan, L. Abrahamyan, P. Pechlivanoglou, V. Rac, N. Pojskic, Elizabeth A. Bojarski, J. Su, M. Krahn, S. Cadarette
Background: MedsCheck Annual (MCA) is an Ontario government-funded medication review service for individuals taking 3 or more prescription medications for chronic conditions. Methods: This cohort study analyzed linked administrative claims data from April 1, 2007, to March 31, 2013. Trends in MCA claims and recipient characteristics were examined. Results: A total of 1,498,440 Ontarians (55% seniors, 55% female) received an MCA. One-third (36%) had 2 or more MCAs within 6 years. Service provision increased over time, with a sharper increase from 2010 onward. Almost half of Ontario pharmacies made at least 1 MCA claim in the first month of the program. Hypertension, respiratory disease, diabetes, psychiatric conditions and arthritis were common comorbidities. Recipients older than 65 years were most commonly dispensed an antihypertensive and/or antihyperlipidemic drug in the prior year and received an average of 11 unique prescription medications. Thirty-eight percent of recipients visited an emergency department or were hospitalized in the year prior to their first MCA. Discussion: Over the first 6 years of the program, approximately 1 in 9 Ontarians received an MCA. There was rapid and widespread uptake of the service. Common chronic conditions were well represented among MCA recipients. Older MCA recipients had less emergency department use compared with population-based estimates. Conclusions: Medication reviews increased over time; however, the number of persons receiving the service more than once was low. Service delivery was generally consistent with program eligibility; however, there are some findings possibly consistent with delivery to less complex patients.
背景:MedsCheck年度(MCA)是安大略省政府资助的一项药物审查服务,针对服用3种或更多处方药治疗慢性疾病的个人。方法:本队列研究分析了2007年4月1日至2013年3月31日的相关行政索赔数据。研究了MCA索赔的趋势和接受者的特征。结果:共有1,498,440名安大略省人(55%为老年人,55%为女性)获得了MCA。三分之一(36%)的患者在6年内有2次或更多的mca。服务供应随着时间的推移而增加,自2010年以来增长幅度更大。几乎一半的安大略省药房在该计划的第一个月至少提出了一次MCA索赔。高血压、呼吸系统疾病、糖尿病、精神疾病和关节炎是常见的合并症。年龄大于65岁的受助人在前一年最常被分配抗高血压和/或抗高血脂药物,平均接受11种独特的处方药。38%的受助人在第一次MCA前一年曾去过急诊科或住院。讨论:在该计划的前6年里,大约每9个安大略省人中就有1个获得了MCA。这项服务得到了迅速而广泛的接受。常见的慢性疾病在MCA接受者中有很好的代表性。与基于人口的估计相比,老年MCA接受者使用急诊室的次数较少。结论:药物回顾随着时间的推移而增加;然而,接受一次以上服务的人数很少。提供的服务大体上符合项目资格;然而,有一些发现可能与对不太复杂的患者的治疗一致。
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引用次数: 44
Pharmacy practice research produces findings that inform how pharmacists contribute to optimal drug therapy outcomes for Canadians 药学实践研究产生的发现,告知药剂师如何为加拿大人的最佳药物治疗结果做出贡献
IF 1.5 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2016-08-08 DOI: 10.1177/1715163516663693
L. Dolovich, R. Tsuyuki
You know that life as a pharmacist is busy. So many different activities to juggle—often all at the same time. There are multiple prescriptions to review and assess. There are medication reviews, immunizations, blood pressure or other services to organize, prioritize and provide. Patients or their family members want answers to questions about medications or health. Other health care providers need answers to medication questions that they have sent by phone, text or email. There are care plans to develop and case conferences to participate in. And this is just a partial list. How do you make sense of it all?
你知道药剂师的生活很忙。有那么多不同的活动要兼顾,而且往往都是在同一时间。有多种处方需要审查和评估。有药物审查、免疫接种、血压或其他服务需要组织、优先考虑和提供。病人或他们的家人想知道有关药物或健康问题的答案。其他医疗服务提供者需要他们通过电话、短信或电子邮件发送的药物问题的答案。有护理计划要制定,有病例会议要参加。这只是部分列表。你是怎么理解这一切的?
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引用次数: 5
Pharmacists without Borders Canada 加拿大无国界药剂师组织
IF 1.5 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2016-08-02 DOI: 10.1177/1715163516662816
S. Levesque
With your recent coverage of the important work of pharmacists during natural disasters,1,2 I thought it would be an opportune time to update CPJ readers about a pharmacist organization that has spent decades working in areas around the world in greatest need of medical and pharmaceutical aid.
鉴于你们最近对自然灾害期间药剂师重要工作的报道,我认为现在是向CPJ读者介绍一个在世界上最需要医疗和药物援助的地区工作了几十年的药剂师组织的好时机。
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引用次数: 1
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Canadian Pharmacists Journal
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