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Post-traumatic stress among adolescents following the October 7th attack in Israel: implications for mental health policy and planning. 10月7日以色列袭击事件后青少年的创伤后应激:对心理健康政策和规划的影响。
IF 2.2 4区 医学 Q1 HEALTH POLICY & SERVICES Pub Date : 2025-12-12 DOI: 10.1186/s13584-025-00740-1
Tehila Refaeli, Agat Sold, Limor Aharonson-Daniel

Background: The October 7th, 2023, attack in Israel and the ensuing war exposed Israeli youth to intense and prolonged traumatic stress. This study aimed to: (1) examine the prevalence of probable post-traumatic stress disorder (PTSD) among Israeli adolescents, and (2) identify associated risk and resilience factors for PTSD symptoms within the context of prolonged exposure to threat and uncertainty due to ongoing war and conflict.

Methods: A cross-sectional digital survey was conducted between October and December 2024. Data were collected from 744 adolescents aged 14-18 years, including the Child PTSD Symptom Scale (CPSS-SR-5), questions about direct war-related consequences and indirect exposure. Personal resilience was assessed using the Connor-Davidson Resilience Scale. Social support was measured using the Multidimensional Scale of Perceived Social Support (MSPSS). Background questions addressed age, gender, health, and adverse events in the past year. Hierarchical multiple regression analysis was used to examine the contribution of background variables, war-related effects, indirect exposure, and resilience factors to PTSD symptoms.

Results: The study revealed that 41.9% of participants met the probable diagnostic threshold for PTSD. Gender (female), poorer health status, and previous adverse experiences correlated with increased symptom severity. Among the direct effects, economic status deterioration and direct war impact emerged as significant predictors. Among the indirect exposure factors, frequent news consumption was associated with higher PTSD symptoms. Personal resilience and family support were associated with reduced PTSD symptoms, although resilience factors did not significantly moderate the adverse impacts of war-related experiences.

Conclusions: The high prevalence of probable PTSD among Israeli adolescents in the wake of the October 7th, 2023 attack suggests an urgent need for action. Evidence-informed mental health policies and services should prioritize adolescents, with targeted support for high-risk groups. Our findings stress the need for a national mental health policy to incorporate youth-centered trauma response systems, including interventions for indirect media trauma. Strengthening personal resilience and bolstering family support systems is vital in order to mitigate the lasting psychological impact of war-related trauma on youth.

背景:2023年10月7日发生在以色列的袭击事件和随后的战争使以色列年轻人承受了强烈而持久的创伤压力。本研究旨在:(1)调查以色列青少年创伤后应激障碍(PTSD)的患病率;(2)在持续战争和冲突造成的威胁和不确定性的长期暴露背景下,确定PTSD症状的相关风险和恢复因素。方法:于2024年10月至12月进行横断面数字调查。研究收集了744名14-18岁青少年的数据,包括儿童创伤后应激障碍症状量表(CPSS-SR-5)、直接战争相关后果和间接暴露的问题。采用康纳-戴维森弹性量表评估个人弹性。社会支持采用感知社会支持多维量表(MSPSS)进行测量。背景问题涉及年龄、性别、健康状况和过去一年的不良事件。采用层次多元回归分析来检验背景变量、战争相关影响、间接暴露和恢复力因素对PTSD症状的贡献。结果:41.9%的参与者达到了PTSD的可能诊断阈值。性别(女性)、较差的健康状况和既往不良经历与症状严重程度增加相关。在直接影响中,经济状况恶化和直接战争影响成为重要的预测因素。在间接暴露因素中,频繁的新闻消费与较高的PTSD症状相关。个人恢复力和家庭支持与创伤后应激障碍症状的减轻有关,尽管恢复力因素并没有显著缓解战争相关经历的不利影响。结论:2023年10月7日袭击事件后,以色列青少年中可能存在的PTSD患病率很高,这表明迫切需要采取行动。循证精神卫生政策和服务应优先考虑青少年,并为高危群体提供有针对性的支持。我们的研究结果强调了国家心理健康政策的必要性,以纳入以青年为中心的创伤反应系统,包括间接媒体创伤的干预措施。为了减轻与战争有关的创伤对青年的持久心理影响,加强个人复原力和加强家庭支持系统至关重要。
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引用次数: 0
The rise in child injuries involving all-terrain vehicles in Israel: a call to action. 以色列涉及全地形车辆的儿童受伤人数上升:呼吁采取行动。
IF 2.2 4区 医学 Q1 HEALTH POLICY & SERVICES Pub Date : 2025-12-10 DOI: 10.1186/s13584-025-00739-8
Aviad Agam, Francis B Mimouni, Yigal Godler, Elad Calif, Joseph Mendlovic

Background: The first five months of 2025 marked a sharp and troubling increase in child injuries involving All-Terrain Vehicles (ATVs) in Israel. During this short period, 17 children were reported as injured or killed in ATV-related incidents - three fatally - with a mean age of 12.5 years (median: 14). This represents a 263% rise compared to previous annual rates, highlighting serious concerns regarding the effectiveness of existing legislation, enforcement and public awareness. The purpose of this study is to analyze long-term trends in ATV-related child injuries and assess the urgent need for regulatory and preventive interventions.

Methods: We conducted a retrospective analysis of unintentional childhood injuries involving ATVs using Beterem Safe Kids Israel's media-based pediatric injury database, from 2008 until May 2025. Trends over time were analyzed using best-fit regression models, and group differences were tested using chi-square tests of independence.

Results: Between 2008 and May 2025, 378 ATV-related injuries among children and adolescents were documented, including 41 fatalities. A clear upward trend was observed, with the annual average rising from 21.9 cases per year (2008-2019) to 43 cases per year (2020-2025), and with 22 cases already reported in 2025. Severe and fatal cases more than doubled during this period. Arab children were overrepresented relative to their population share. Incidents peaked during weekends and holidays. A significant quadratic increase in mortality rates over time was identified (R² = 0.751, P < 0.001). ATV-related injuries were disproportionately concentrated among children from lower socioeconomic backgrounds, with 95% of Arab victims and 74% of Jewish victims residing in low- or mid-ranking municipalities.

Conclusions: ATVs present an escalating and preventable danger to child safety in Israel, with recent data signaling a critical and worsening trend. Immediate and decisive action is imperative. Policymakers must urgently implement a uniform minimum age for ATV operation, mandate safety technologies (e.g., Operator Protective Devices), require physical capability assessments, and launch targeted public awareness and enforcement campaigns-especially in rural and underserved communities. These measures are essential to safeguarding children and reversing the alarming trajectory of ATV-related harm.

背景:2025年前5个月,以色列全地形车(atv)造成的儿童伤害急剧增加,令人不安。在这短时间内,据报告有17名儿童在与全沙滩车有关的事件中受伤或死亡,其中3人死亡,平均年龄为12.5岁(中位数:14岁)。与以往的年度增长率相比,这一数字上升了263%,凸显了人们对现有立法、执法和公众意识的有效性的严重担忧。本研究的目的是分析atv相关儿童伤害的长期趋势,并评估监管和预防干预措施的紧迫性。方法:从2008年到2025年5月,我们使用Beterem安全儿童以色列媒体儿童伤害数据库对涉及全地形车的意外儿童伤害进行了回顾性分析。使用最佳拟合回归模型分析随时间变化的趋势,使用卡方独立性检验检验组间差异。结果:在2008年至2025年5月期间,记录了378例儿童和青少年与atv相关的伤害,其中41例死亡。观察到明显的上升趋势,年平均病例数从每年21.9例(2008-2019年)上升到每年43例(2020-2025年),2025年已报告22例。在此期间,严重和致命病例增加了一倍多。相对于其人口比例,阿拉伯儿童的比例过高。事故在周末和节假日期间达到高峰。结论:在以色列,全地形车对儿童安全构成了不断升级的、可预防的危险,最近的数据表明这是一个严重且日益恶化的趋势。必须立即采取果断行动。政策制定者必须立即实施统一的ATV操作最低年龄,强制要求安全技术(如操作人员防护装置),要求进行体能评估,并开展有针对性的公众意识和执法活动,特别是在农村和服务不足的社区。这些措施对于保护儿童和扭转与全地形车有关的令人震惊的伤害轨迹至关重要。
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引用次数: 0
The Israeli eye care system through a public and global health lens. 以色列的眼保健系统通过公共和全球健康的镜头。
IF 2.2 4区 医学 Q1 HEALTH POLICY & SERVICES Pub Date : 2025-12-08 DOI: 10.1186/s13584-025-00731-2
Mattan Arazi, Marcia Zondervan, Asaf Israeli, Hadash Maoz, Cova Bascaran Fanego
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引用次数: 0
Factors associated with using disposable versus non-disposable electronic cigarettes among adults in the U.S. and Israel: a cross-sectional study with policy implications. 美国和以色列成年人使用一次性和非一次性电子烟的相关因素:一项具有政策意义的横断面研究
IF 2.2 4区 医学 Q1 HEALTH POLICY & SERVICES Pub Date : 2025-12-03 DOI: 10.1186/s13584-025-00738-9
Begashaw A Mulu, Carla J Berg, Hagai Levine, Lorien C Abroms, Yan Wang, Yael Bar-Zeev

Background: In recent years, there has been a rapid increase in disposable electronic cigarette (e-cigarette) use. Several countries have banned or are considering banning disposable e-cigarettes, which might affect adults who use disposable e-cigarettes for harm reduction. Understanding patterns of disposable versus non-disposable e-cigarette use among adults who currently use e-cigarettes is essential to inform possible regulations and policy. This study explored factors associated with disposable versus non-disposable e-cigarette use among adults currently using e-cigarettes in the U.S. and Israel.

Method: A cross-sectional online survey was conducted (October-December 2021) among 410 U.S. and Israeli adults aged 18-45 years (mean age 30.8 ± 7.6) who reported past 30-day e-cigarette use (62.9% of whom used non-disposables). A multivariate logistic regression assessed factors associated with disposable versus non-disposable e-cigarette use, stratified by country.

Result: In Israel, a greater perceived harm of e-cigarettes (aOR = 1.45, 95%CI: 1.20-1.76), cannabis/cannabinoid-containing e-liquid use ( aOR 0.36, 95%CI: 0.19-0.69) and purchasing from 'regular' shops (aOR = 6.30, 95%CI: 2.25-17.67) or 'specialty' shops (aOR = 3.71, 95%CI: 1.21-11.34) (compared to 'online' shops) were associated with disposable e-cigarette use. In the U.S., factors associated with disposable e-cigarette use included ever using other tobacco/nicotine products (aOR = 7.51, 95%CI: 1.49-37.87), sweet flavor preference (aOR = 4.42, 95%CI: 1.64-11.94), cannabis/cannabinoid-containing e-liquid use (aOR = 0.33, 95% CI: 0.13-0.82), and being 26-35 years old (vs. 36-45) (aOR = 0.36, 95% CI: 0.13-0.98).

Conclusions: U.S. and Israeli adults who use disposable versus non-disposable e-cigarettes differ, highlighting the importance of public health strategies tailored to the unique needs of each country. The high levels of cannabis or cannabinoid-containing e-liquid use among participants who use non-disposable e-cigarettes suggest the need for stricter regulation and enforcement of non-disposable devices and e-liquids in both countries. Findings also suggest that banning sweet flavored e-cigarettes will support the effort in reduction of disposable e-cigarette use in the U.S.

背景:近年来,一次性电子烟(电子烟)的使用迅速增加。一些国家已经禁止或正在考虑禁止一次性电子烟,这可能会影响使用一次性电子烟的成年人,以减少危害。了解目前使用电子烟的成年人使用一次性和非一次性电子烟的模式对于制定可能的法规和政策至关重要。这项研究探讨了美国和以色列目前使用电子烟的成年人使用一次性电子烟和非一次性电子烟的相关因素。方法:对410名年龄在18-45岁(平均年龄30.8±7.6岁)的美国和以色列成年人(其中62.9%使用非一次性电子烟)进行了横断面在线调查(2021年10月至12月)。多变量逻辑回归评估了按国家分层的一次性和非一次性电子烟使用相关因素。结果:在以色列,使用电子烟(aOR = 1.45, 95%CI: 1.20-1.76)、使用大麻/含大麻素的电子烟液(aOR = 0.36, 95%CI: 0.19-0.69)以及从“常规”商店(aOR = 6.30, 95%CI: 2.25-17.67)或“专业”商店(aOR = 3.71, 95%CI: 1.21-11.34)(与“在线”商店相比)购买电子烟的危害更大。在美国,与一次性电子烟使用相关的因素包括曾经使用过其他烟草/尼古丁产品(aOR = 7.51, 95%CI: 1.49-37.87),甜味偏好(aOR = 4.42, 95%CI: 1.64-11.94),大麻/含大麻素的电子烟液体使用(aOR = 0.33, 95%CI: 0.13-0.82),以及26-35岁(aOR = 0.36, 95%CI: 0.13-0.98)。结论:美国和以色列使用一次性电子烟和非一次性电子烟的成年人有所不同,这突出了针对每个国家独特需求量身定制公共卫生战略的重要性。在使用非一次性电子烟的参与者中,大麻或含大麻素的电子液体使用量很高,这表明两国需要对非一次性设备和电子液体进行更严格的监管和执法。研究结果还表明,禁止甜味电子烟将有助于减少美国一次性电子烟的使用
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引用次数: 0
Plugging the drain: targeted policies for retaining Israeli doctors. 堵塞流失:有针对性的政策,以留住以色列医生。
IF 2.2 4区 医学 Q1 HEALTH POLICY & SERVICES Pub Date : 2025-11-28 DOI: 10.1186/s13584-025-00737-w
Yoel Angel, Nevo Barel, Gil Fire

Israel's physician workforce crisis reflects long-standing dependence on foreign-trained doctors, limited domestic capacity, and the shrinking inflow of new graduates following the Yatziv Reform. Recent analyses underscore the need not only to expand local training but also to better track and support Israelis studying and training abroad. While new data such as that by Swechinsky and Berner-Shalem shed light on return patterns among students, a less visible challenge lies with physicians leaving the Israeli health system, and specifically those undertaking fellowship training overseas who choose not to return. Building reliable data systems and proactive engagement mechanisms for both students and fellows is essential to securing Israel's future medical workforce.

以色列的医生劳动力危机反映了长期以来对外国培训医生的依赖,国内能力有限,以及亚茨夫改革后新毕业生流入的减少。最近的分析强调,不仅需要扩大当地培训,而且需要更好地跟踪和支持在国外学习和培训的以色列人。虽然斯威金斯基和伯纳-沙勒姆等新数据揭示了学生回国的模式,但一个不太明显的挑战在于离开以色列卫生系统的医生,特别是那些在海外接受奖学金培训的医生,他们选择不回国。为学生和研究员建立可靠的数据系统和主动参与机制对于确保以色列未来的医疗劳动力至关重要。
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引用次数: 0
Beyond trauma: knowledge and training gaps among mental health professionals in the aftermath of October 7th 2023. 超越创伤:2023年10月7日之后精神卫生专业人员的知识和培训差距。
IF 2.2 4区 医学 Q1 HEALTH POLICY & SERVICES Pub Date : 2025-11-27 DOI: 10.1186/s13584-025-00734-z
Or Keynan, Dana Elberg, Shlomo Mendlovic, Ido Lurie, Doron Amsalem, Yuval Neria, Yossi Levi-Belz, Milton Wainberg, David Roe, Asala Halaj, Dana Tzur Bitan
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引用次数: 0
Where, when, and how to close dialysis access gaps: incorporation of geographic information system into data-driven planning : A commentary. 何时、何地以及如何缩小透析获取差距:将地理信息系统纳入数据驱动的规划:评论。
IF 2.2 4区 医学 Q1 HEALTH POLICY & SERVICES Pub Date : 2025-11-26 DOI: 10.1186/s13584-025-00724-1
Gina S Lovasi, Richard Remigio
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引用次数: 0
Toward climate resilience in Israel's healthcare system: decision-makers' perspectives. 以色列医疗保健系统的气候适应能力:决策者的观点。
IF 2.2 4区 医学 Q1 HEALTH POLICY & SERVICES Pub Date : 2025-11-24 DOI: 10.1186/s13584-025-00729-w
Irit Lador, Maya Negev, Anat Rosenthal, Stav Shapira

Background: Climate change is increasingly recognized as a major global health threat, highlighting the need to enhance climate resilience within health systems. The World Health Organization (WHO) defines key components for climate-resilient health systems, including governance, financing, workforce, and emergency preparedness. Israel is particularly vulnerable to climate change, which is expected to exacerbate the strain on a healthcare system already facing budget cuts, staff shortages, equipment deficits, and security challenges. We aimed to analyze the barriers to and facilitators of climate resilience initiatives in Israel's healthcare system from the perspective of decision-makers. Understanding the unique contextual factors within Israel's healthcare system can inform the development of a tailored climate and health framework and shape national policy.

Methods: In this qualitative study, semi-structured interviews were conducted with 25 decision-makers, administrators, and professionals from the Ministry of Health, hospitals, and health maintenance organizations (HMOs). Participants were selected using purposive sampling to ensure diverse representation. Data were analyzed through deductive thematic analysis, guided by the Consolidated Framework for Implementation Research (CFIR).

Results: The absence of a national policy framework, including dedicated funding and binding regulations, emerged as a central barrier to advancing climate resilience within the Israeli healthcare system. Additionally, the study revealed that climate issues are deprioritized due to security and budgetary constraints, coupled with limited awareness of climate risks. Economic incentives were frequently cited as enablers for promoting climate resilience. Despite challenges, the findings highlight the potential for integrating climate resilience into existing emergency preparedness systems.

Conclusions: The study underscores significant gaps in climate resilience within Israel's healthcare system, particularly the lack of a coordinated, government-led framework for climate adaptation. Although local efforts exist, they remain fragmented and unsustainable without national leadership and funding. Key recommendations include developing a comprehensive national health and climate plan, securing dedicated funding, and increasing awareness/training for healthcare professionals.

背景:人们日益认识到气候变化是一个主要的全球健康威胁,这突出表明需要在卫生系统内加强气候适应能力。世界卫生组织(世卫组织)定义了气候适应型卫生系统的关键组成部分,包括治理、融资、劳动力和应急准备。以色列特别容易受到气候变化的影响,预计气候变化将加剧其医疗保健系统的压力,该系统已经面临预算削减、人员短缺、设备短缺和安全挑战。我们旨在从决策者的角度分析以色列医疗保健系统中气候适应能力举措的障碍和促进因素。了解以色列医疗保健系统内的独特背景因素可以为量身定制的气候和健康框架的发展提供信息,并形成国家政策。方法:采用半结构化访谈法,对25名来自卫生部、医院和健康维护机构的决策者、管理人员和专业人员进行访谈。参与者选择使用有目的的抽样,以确保多样化的代表性。在实施研究综合框架(CFIR)的指导下,通过演绎主题分析对数据进行分析。结果:缺乏国家政策框架,包括专门的资金和有约束力的法规,成为促进以色列医疗保健系统内气候适应能力的主要障碍。此外,该研究还显示,由于安全和预算限制,加上对气候风险的认识有限,气候问题被置于次要地位。经济激励经常被认为是促进气候适应能力的推动因素。尽管存在挑战,但研究结果强调了将气候适应能力纳入现有应急准备系统的潜力。结论:该研究强调了以色列医疗保健系统在气候适应能力方面的重大差距,特别是缺乏一个协调的、政府主导的气候适应框架。虽然存在地方努力,但在没有国家领导和资金的情况下,这些努力仍然是零散的,不可持续的。主要建议包括制定一项全面的国家卫生和气候计划,确保专门的资金,以及提高卫生保健专业人员的认识/培训。
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引用次数: 0
Enhancing resilience of nursing education during war: policy implications from a qualitative study. 加强战争期间护理教育的复原力:一项定性研究的政策含义。
IF 2.2 4区 医学 Q1 HEALTH POLICY & SERVICES Pub Date : 2025-11-17 DOI: 10.1186/s13584-025-00732-1
Ilya Kagan, Odeya Cohen

Background: Education of nurses may be compromised during a crisis. On October 7, 2023, the "Iron Swords" war broke out in Israel. The academic year was postponed, and nursing education was disrupted. Despite the acknowledged importance of continuing nurse training during emergencies, research on this topic is scarce.

Aim: To examine nursing school management activities and describe the adaptive strategies of academic frameworks during the war in Israel.

Design and methods: This qualitative study was conducted in nursing schools in Israel that were directly affected by the Iron Swords War (October 7, 2023). We interviewed five of the seven chairs of nursing departments in Iron Swords conflict zones, content analyzed the interview text, and employed COREQ reporting guidelines for this qualitative study.

Results: Six main themes were identified: Management and leadership under uncertainty; Resilience and preparedness; Supporting well-being and inclusivity; Adaptability and innovation in the educational process; Fostering a sense of community; and Engagement of students and faculties in the crisis response. One of the most remarkable findings was the blending of personal and professional roles, as manifested in the immediate response and re-organization by the academic and administrative staff.

Discussion: The ability of academia to maintain function and make decisions under conditions of uncertainty is of paramount importance. This requires collaborative decision-making, leveraging diverse perspectives, fostering inclusivity, and enhancing the effectiveness of responses. Maintaining routines creates a feeling of belonging, promotes setting and realization of goals, provides meaning, and maintains motivation.

Conclusions: The results provide insights into the management of nursing education during prolonged emergencies and health policy implications. Although focused on a war scenario, the findings have broader implications and offer strategies applicable to more general crises.

背景:护士教育在危机中可能会受到影响。2023年10月7日,“铁剑”战争在以色列爆发。学年被推迟,护理教育中断。尽管在紧急情况下对护士进行持续培训的重要性得到公认,但关于这一主题的研究却很少。目的:研究以色列战争期间护理学校的管理活动,并描述学术框架的适应策略。设计与方法:本定性研究在以色列的护理学校进行,这些学校直接受到铁剑战争(2023年10月7日)的影响。我们采访了铁剑冲突地区7位护理部门主任中的5位,对访谈文本进行内容分析,并采用COREQ报告指南进行定性研究。结果:确定了六个主题:不确定性下的管理与领导;复原力和准备;支持福祉和包容性;教育过程中的适应性与创新性培养社区意识;学生和教师参与危机应对。最显著的发现之一是个人作用和专业作用的混合,这体现在学术和行政工作人员的迅速反应和重组上。讨论:学术界在不确定条件下维持职能和做出决策的能力是至关重要的。这需要协作决策,利用不同观点,促进包容性,并提高应对措施的有效性。维持日常生活可以创造一种归属感,促进目标的设定和实现,提供意义,并保持动力。结论:本研究结果对急诊护理教育管理及卫生政策具有重要意义。尽管研究的重点是战争场景,但研究结果具有更广泛的意义,并提供了适用于更普遍危机的策略。
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引用次数: 0
Trends in compassionate use of medicinal products: Israel 2020-2024. 医疗产品慈悲使用的趋势:以色列2020-2024。
IF 2.2 4区 医学 Q1 HEALTH POLICY & SERVICES Pub Date : 2025-11-13 DOI: 10.1186/s13584-025-00730-3
Eyal Schwartzberg, Eli Marom, Victoria Finkel-Pekarsky, Segev Shani, Miriam Cohen Kandli, Mohammed Aboukaoud

Background: Compassionate use programs allow patients with life-threating and serious conditions to access investigational therapies when standard treatments are inadequate. This study aims to analyze the trends and outcomes of the compassionate use of medicinal products in Israel.

Methods: Data from the Israeli Ministry of Health's compassionate use database (2020-2024) were anonymized and analyzed. Duplicates were removed, and a pivot table was used to assess factors such as active ingredients, indications, treatment counts, and patient demographics. Results were presented as counts and percentages, with treatments over 0.5% of the total classified as common. Statistical analyses included Student's t-test and chi-squared test for subgroup differences (p < 0.05 significant). Commonly used medicinal products were cross-referenced with the MOH drug database for registration and reimbursement status.

Results: A total of 3,284 compassionate treatments were administered, employing 596 distinct medicinal products to address 1,361 conditions in 2020-2024. Temporal analysis identified a peak in 2020, which accounted for 24% of total treatments, followed by a decrease thereafter. Patient age stratification indicated that those aged 65 to 80 received the highest treatment proportion (26%), while the 45 to 65 age group accounted for 19%. Treatments were mainly concentrated in large central hospitals (77%) and the central district (49%), with the southern district showing the least usage. The authorization process was primarily for the continuation of study drug in 63% of cases. Additionally, Belantamab mafodotin and Trametinib were the most frequently utilized medicinal products, accounting for 9% and 8.6% of treatments, respectively. Disease category analysis revealed that relapsed refractory multiple myeloma, central nervous system tumors, and inflammatory bowel disease were among the top conditions treated, varying by age group. Notably, 60% of the most common technologies (13 out of 22) were subsequently included into the national health basket, typically following an extended period of compassionate use that exceeded two years.

Conclusion: The study suggests that Israel's compassionate use programs have accelerated early access to novel therapies for complex conditions and provided a bridge to the inclusion of novel medicinal products in the national health basket. Nonetheless, the study identifies a concerning downward trend in utilization alongside potential access disparities, thereby underscoring the necessity for further targeted investigations.

背景:体恤使用项目允许有生命危险和严重疾病的患者在标准治疗不充分的情况下获得研究性治疗。本研究的目的是分析趋势和结果的医疗产品的同情使用在以色列。方法:对来自以色列卫生部关爱用药数据库(2020-2024)的数据进行匿名化分析。删除重复项,并使用数据透视表来评估诸如有效成分、适应症、治疗计数和患者人口统计等因素。结果以计数和百分比表示,超过0.5%的治疗被归类为普通治疗。统计分析包括亚组差异的学生t检验和卡方检验(p)结果:在2020-2024年期间,共实施了3284项富有同情心的治疗,使用了596种不同的药物来解决1361种疾病。时间分析发现,2020年达到峰值,占总治疗量的24%,随后下降。患者年龄分层显示,65 ~ 80岁患者接受治疗比例最高(26%),45 ~ 65岁患者占19%。治疗主要集中在大型中心医院(77%)和中心区(49%),南区使用率最低。在63%的病例中,批准程序主要是为了继续研究药物。此外,贝兰他单和曲美替尼是使用频率最高的药品,分别占治疗的9%和8.6%。疾病类别分析显示,复发的难治性多发性骨髓瘤、中枢神经系统肿瘤和炎症性肠病是治疗的主要疾病,因年龄组而异。值得注意的是,60%的最常见技术(22项技术中的13项)随后被纳入国家卫生篮子,通常是在长期使用两年以上的同情性使用之后。结论:该研究表明,以色列的同情心使用计划加速了复杂疾病的新疗法的早期获得,并为将新药品纳入国家卫生篮子提供了一座桥梁。尽管如此,该研究确定了令人担忧的使用率下降趋势以及潜在的获取差距,从而强调有必要进一步进行有针对性的调查。
{"title":"Trends in compassionate use of medicinal products: Israel 2020-2024.","authors":"Eyal Schwartzberg, Eli Marom, Victoria Finkel-Pekarsky, Segev Shani, Miriam Cohen Kandli, Mohammed Aboukaoud","doi":"10.1186/s13584-025-00730-3","DOIUrl":"10.1186/s13584-025-00730-3","url":null,"abstract":"<p><strong>Background: </strong>Compassionate use programs allow patients with life-threating and serious conditions to access investigational therapies when standard treatments are inadequate. This study aims to analyze the trends and outcomes of the compassionate use of medicinal products in Israel.</p><p><strong>Methods: </strong>Data from the Israeli Ministry of Health's compassionate use database (2020-2024) were anonymized and analyzed. Duplicates were removed, and a pivot table was used to assess factors such as active ingredients, indications, treatment counts, and patient demographics. Results were presented as counts and percentages, with treatments over 0.5% of the total classified as common. Statistical analyses included Student's t-test and chi-squared test for subgroup differences (p < 0.05 significant). Commonly used medicinal products were cross-referenced with the MOH drug database for registration and reimbursement status.</p><p><strong>Results: </strong>A total of 3,284 compassionate treatments were administered, employing 596 distinct medicinal products to address 1,361 conditions in 2020-2024. Temporal analysis identified a peak in 2020, which accounted for 24% of total treatments, followed by a decrease thereafter. Patient age stratification indicated that those aged 65 to 80 received the highest treatment proportion (26%), while the 45 to 65 age group accounted for 19%. Treatments were mainly concentrated in large central hospitals (77%) and the central district (49%), with the southern district showing the least usage. The authorization process was primarily for the continuation of study drug in 63% of cases. Additionally, Belantamab mafodotin and Trametinib were the most frequently utilized medicinal products, accounting for 9% and 8.6% of treatments, respectively. Disease category analysis revealed that relapsed refractory multiple myeloma, central nervous system tumors, and inflammatory bowel disease were among the top conditions treated, varying by age group. Notably, 60% of the most common technologies (13 out of 22) were subsequently included into the national health basket, typically following an extended period of compassionate use that exceeded two years.</p><p><strong>Conclusion: </strong>The study suggests that Israel's compassionate use programs have accelerated early access to novel therapies for complex conditions and provided a bridge to the inclusion of novel medicinal products in the national health basket. Nonetheless, the study identifies a concerning downward trend in utilization alongside potential access disparities, thereby underscoring the necessity for further targeted investigations.</p>","PeriodicalId":46694,"journal":{"name":"Israel Journal of Health Policy Research","volume":"14 1","pages":"66"},"PeriodicalIF":2.2,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12613603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145507258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Israel Journal of Health Policy Research
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