Journal of Taibah University Medical Sciences最新文献

{"title":"Expression of alpha-smooth muscle actin in salivary mucoepidermoid and adenoid cystic carcinomas: A comparative immunohistochemical study","authors":"Shatha A. Alsalman Ph.D Lecturer ,&nbsp;Israa M. Alsudani FIBMS professor ,&nbsp;Sultan L. Al-Janabi Medical Student","doi":"10.1016/j.jtumed.2025.09.006","DOIUrl":"10.1016/j.jtumed.2025.09.006","url":null,"abstract":"<div><h3>Background</h3><div>Alpha-smooth muscle actin (α-SMA) is crucial in fibrogenesis. Salivary gland tumor types exhibit varying degrees of α-SMA expression because myoepithelial cells play diverse roles in their formation. The present study compared the immunohistochemical expression of α-SMA in mucoepidermoid and adenoid cystic carcinoma according to the grades and variants.</div></div><div><h3>Methodology</h3><div>Sections of formalin-fixed, paraffin-embedded tissue blocks obtained from 50 cases of salivary gland carcinoma from 2011 to 2021 were stained using α-SMA monoclonal antibodies for immunohistochemical analysis.</div></div><div><h3>Results</h3><div>The mean α-SMA scores did not differ significantly among the three mucoepidermoid carcinoma histology levels. No notable variations in α-SMA expression were observed in the mucoepidermoid carcinoma cases analyzed. By contrast, high-grade adenoid cystic carcinoma cases had substantially higher α-SMA scores than cases with low or intermediate grades. The α-SMA scores did not differ significantly between the low and intermediate grades. Among the histological variants, more cases with highly significant α-SMA scores were found in solid types compared with tubular, cribriform, or combined types. Furthermore, patients with cribriform growth had significantly higher α-SMA scores than those with tubular tumor growth. Overall, the percentage of high reactivity (expression) (α-SMA score 4+) was significantly higher in adenoid cystic carcinoma cases than mucoepidermoid carcinoma cases.</div></div><div><h3>Conclusions</h3><div>These findings highlight the importance of α-SMA as a tumor marker for differentiating between mucoepidermoid and adenoid cystic carcinoma in terms of the tumor grading, histological variant, and expression.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 5","pages":"Pages 719-725"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the new characteristics of professionalism in nursing from the perspective of experts: A qualitative Study","authors":"Sakineh Parastesh PhD Student ,&nbsp;Mohammadali Hosseini PhD ,&nbsp;Farahnaz Mohammadi-Shahbolaghi PhD ,&nbsp;Sadat S.B. Maddah PhD ,&nbsp;Abbas Ebadi PhD","doi":"10.1016/j.jtumed.2025.09.003","DOIUrl":"10.1016/j.jtumed.2025.09.003","url":null,"abstract":"<div><h3>أهداف البحث</h3><div>أصبحت الاحترافية مؤخرا من أهم القضايا في مهنة التمريض. يرى الممرضون أن المشكلة الرئيسية التي تؤثر على الاحترافية هي إهمال رأي الخبراء في تحديد وتطوير مؤشرات الاحترافية في التمريض. تناولت هذه الدراسة خصائص الاحترافية في التمريض من وجهة نظر الخبراء.</div></div><div><h3>طرق البحث</h3><div>تُعد هذه الدراسة الجزء الثاني من تحليل مفاهيمي للاحترافية في التمريض (مقابلة شبه منظمة)، والذي أُجري باستخدام أسلوب تحليل المحتوى النوعي. شملت الدراسة 17 خبيرا من أعضاء هيئة التدريس في التمريض، وثلاثة مديري تمريض، ورئيسي تمريض، وممرضين سريريين ذوي خبرة، وطبيبين عامين، ومديري مستشفيات، والذين تم اختيارهم من ست جامعات للعلوم الطبية. تم اختيارهم باستخدام أسلوبي العينة الهادفة والتراكمية، وأُجريت معهم مقابلات. تم تحليل البيانات باستخدام أسلوب تحليل المحتوى الاستنتاجي والموجه.</div></div><div><h3>النتائج</h3><div>بعد تحليل البيانات، تم الحصول على 954 رمزا أوليا، و22 فئة فرعية، وتسع فئات رئيسية. شملت الفئات الرئيسية (خصائص الاحترافية في التمريض): \"المعرفة الأكاديمية المتخصصة\"، و\"السعي المستمر للكفاءة\"، و\"الالتزام بالمدونات والقيم الأخلاقية\"، و\"الالتزام المهني\"، و\"المساءلة\"، و\"الاستقلالية\"، و\"الدعوة\"، و\"التفاعل المهني\"، و\"الوعي الذاتي المهني\". يُعد إدراج فئة \"الوعي الذاتي المهني\" في مصفوفة مراجعة الأدبيات مساهمة مبتكرة لهذه الدراسة. وقد شكّلت هذه الإضافة أساسا لتطوير نموذج مفاهيمي جديد للاحترافية في التمريض.</div></div><div><h3>الاستنتاجات</h3><div>يمكن للإطار المفاهيمي الذي طُوّر في هذه الدراسة أن يُثري السياسات الهادفة إلى جذب الأفراد المؤهلين إلى مهنة التمريض. يُعد الفهم الواضح لسمات الاحترافية، وخاصة الوعي الذاتي المهني، أمرا أساسيا لدخول المهنة. ويمكن لهذا الوعي أن يُعزز المثابرة والرضا الوظيفي لدى الممرضين، بالإضافة إلى المساهمة في تحسين جودة الرعاية وتعزيز رضا العملاء.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 5","pages":"Pages 673-686"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic purchasing through online pharmacies: A mystery shopper study","authors":"Norah O. Abanmy PhD,&nbsp;Sarah A. Alshehri Pharm D,&nbsp;Renad A. Alsudais Pharm D","doi":"10.1016/j.jtumed.2025.09.002","DOIUrl":"10.1016/j.jtumed.2025.09.002","url":null,"abstract":"<div><h3>Introduction</h3><div>The illegal sale of antibiotics through online pharmacies (OPs) can lead to misuse and poses major health risks, because drug quality and authenticity are not ensured. This study was aimed at investigating the extent of illegal online antibiotic sales from both local and international OPs.</div></div><div><h3>Material and <strong>Methods</strong></h3><div>A mystery shopper study was conducted on topical clindamycin, oral amoxicillin, and amoxicillin/clavulanic acid. A search term for each antibiotic in both English and Arabic was used to search Google, Bing, and Yahoo. The first 20 results were obtained, examined, and evaluated according to predetermined criteria. Purchasing was performed according to a systematic approach, to explore whether OPs would sell antibiotics without valid prescriptions, accept outdated prescription, or reject sales.</div></div><div><h3>Results and Discussion</h3><div>At the 60 OPs identified, 22 purchases were made, and ten products were successfully delivered, all from local OPs. Some international OPs requested Bitcoin payment and therefore appeared to be potential scam websites. A substantial number of OPs did not adhere to regulatory requirements, and 33.3 % (20 of 60) did not request prescriptions. Among those OPs, 45 % (9 of 20) were fake, and 45 % (9 of 20) sold topical clindamycin. Whereas 96.7 % of OPs provided contact details, only 13.3 % had quality certifications. Return policies were displayed by 85 % of OPs, and 88.3 % displayed drug information and related warnings, including adverse effects and interactions.</div></div><div><h3>Conclusion</h3><div>Our findings underscore the urgent need for stricter regulations and enhanced monitoring of OPs. However, searching of the dark web, which is known to have illegal marketplaces offering prescription drugs, particularly antibiotics, was not investigated.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 5","pages":"Pages 687-695"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting norovirus RdRp: A computational study on the inhibitory potential of ursolic acid and apigenin-7-O-glucoside","authors":"Mansoor Alsahag PhD","doi":"10.1016/j.jtumed.2025.09.007","DOIUrl":"10.1016/j.jtumed.2025.09.007","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;Norovirus is a highly contagious pathogen responsible for significant global morbidity and mortality due to severe gastrointestinal illnesses, particularly in settings such as schools, hospitals, and cruise ships. Despite its impact on public health, no effective antiviral treatments or vaccines are currently available. This study seeks to identify natural compounds with inhibitory potential against the Norovirus RNA-dependent RNA polymerase (RdRp), an essential enzyme in viral replication. By focusing on phytochemicals, the research aims to propose novel, safe, and effective antiviral agents that could serve as alternatives to synthetic drugs.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A comprehensive in silico approach was employed to screen and evaluate potential inhibitors of Norovirus RdRp. Candidate compounds were first assessed through pharmacokinetic (ADMET) analysis to evaluate their absorption, distribution, metabolism, excretion, and toxicity profiles, ensuring drug-likeness and safety. Toxicological profiling further confirmed the absence of harmful effects in the selected compounds. Molecular docking studies were performed to predict the binding affinities of natural compounds with the RdRp protein (PDB ID: 3ur0), identifying those with the strongest interactions. Molecular dynamics (MD) simulations were then conducted to assess the dynamic stability of the protein-ligand complexes under physiological conditions. Finally, MM-GBSA binding free energy calculations were used to quantitatively validate the strength and stability of the interactions between the compounds and the target protein.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The study identified two lead compounds, Ursolic Acid (CID_64945) and Apigenin-7-O-glucoside (CID_5280704), as potential inhibitors of Norovirus RdRp. Molecular docking studies revealed strong binding affinities, with Ursolic Acid showing a binding score of −8.8 kcal/mol and Apigenin-7-O-glucoside displaying a score of −8.7 kcal/mol. Pharmacokinetic and toxicological evaluations confirmed that both compounds exhibit excellent ADMET profiles, demonstrating favorable absorption, metabolic stability, and minimal toxicity, making them suitable for drug development. Molecular dynamics simulations validated the stability of interactions between the RdRp protein and the two lead compounds over time, with the protein-ligand complexes maintaining consistent and robust interactions throughout the simulation period. MM-GBSA calculations further supported the efficacy of these compounds, as they demonstrated stable and energetically favorable binding to the target protein. Both Ursolic Acid and Apigenin-7-O-glucoside are phytochemicals found in commonly available plants such as rosemary and holy basil, enhancing their accessibility and feasibility for therapeutic use.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;This study identifies Ursolic Acid and Apigenin-7-O-glucoside as promising natural inhibitors of","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 5","pages":"Pages 696-708"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rational emotive behavior therapy for preventing smoking initiation among school children: Addressing peer influence and social susceptibility","authors":"Sari Wardani Simarmata S.Pd., M.Pd.A ,&nbsp;Azizah Batubara M.Pd ,&nbsp;Dony Darma Sagita S.Pd., M.Pd., Kons ,&nbsp;Erwita Ika Violina M.Pd ,&nbsp;Akhmad Syaikhu M.Pd ,&nbsp;Juliana Simangunsong M.Th","doi":"10.1016/j.jtumed.2025.09.008","DOIUrl":"10.1016/j.jtumed.2025.09.008","url":null,"abstract":"","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 5","pages":"Pages 726-727"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145332932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a nurse-led training program in improving the knowledge and skills in basic life support among newly hired nurses at the University Medical Center","authors":"Aida Baizulda ,&nbsp;Akbota Amangeldiyeva ,&nbsp;Gulsharat Metchenova ,&nbsp;Ayaulym Maratkyzy ,&nbsp;Assyltas Yeleussiz ,&nbsp;Askhat Tasbulatov ,&nbsp;Joseph Almazan DScN ,&nbsp;Jonas Cruz PhD","doi":"10.1016/j.jtumed.2025.09.009","DOIUrl":"10.1016/j.jtumed.2025.09.009","url":null,"abstract":"<div><h3>Background</h3><div>Basic Life Support (BLS) is a critical competency for nurses, however its training and evaluation often lack consistency. This issue is particularly evident in Central Asia, where limited evidence exists on scalable and sustainable educational models within medical science education to ensure frontline readiness.</div></div><div><h3>Objective</h3><div>This study evaluated the effectiveness of a nurse-led, simulation-based BLS training program on the knowledge and skills of newly hired nurses at a tertiary academic medical center in Kazakhstan.</div></div><div><h3>Methods</h3><div>A one-group pre-test and post-test design assessed the impact of a structured BLS training program at the University Medical Center in Astana, Kazakhstan. Fifty-two newly hired nurses were enrolled, of whom forty-nine completed all immediate post-intervention assessments. The intervention integrated theoretical instruction, simulation-based practical training, and skills assessments based on European Resuscitation Council guidelines. BLS knowledge was assessed via a 20-item multiple-choice test, and skills were evaluated using a validated checklist. Differences in outcomes across three time points, namely, pre-intervention, immediately post-intervention, and 1–2 months post-intervention, were analyzed using paired <em>t</em>-tests and repeated-measures analysis of variance.</div></div><div><h3>Results</h3><div>Knowledge scores significantly improved immediately after the intervention (M = 18.10, standard deviation [SD] = 2.52) compared to the pre-test (M = 8.71, SD = 3.01; p &lt; 0.001). However, a significant decline was noted at 1 month (M = 11.53, SD = 2.52; p &lt; 0.001). By contrast, practical skills showed continuous improvement, with mean scores increasing from 3.47 (SD = 1.27) pre-intervention to 13.10 (SD = 0.92) at 2 months (p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>This is one of the first studies in Central Asia to evaluate a nurse-led, simulation-based BLS program with follow-up. The findings offer practical implications for medical and nursing education by demonstrating that such models can improve early medical preparedness.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 5","pages":"Pages 728-736"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145332933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From flowers to function: Structural and biomedical exploration of iron oxide nanoparticles synthesized from Rhododendron arboreum extract","authors":"Iram Saba PhD Scholar ,&nbsp;Vivek K. Dhiman PhD ,&nbsp;Susmitha Kalaichelvan PhD ,&nbsp;Rajasekaran Subbarayan PhD ,&nbsp;Ankush Chauhan PhD ,&nbsp;Ritesh Verma PhD ,&nbsp;Khalid Mujasam Batoo PhD ,&nbsp;Saif Hameed PhD ,&nbsp;Ahmed A. Ibrahim PhD","doi":"10.1016/j.jtumed.2025.09.005","DOIUrl":"10.1016/j.jtumed.2025.09.005","url":null,"abstract":"<div><h3>Objectives</h3><div>This study was aimed at developing a green, ecologically friendly method for synthesizing iron oxide nanoparticles (α-Fe₂O₃ NPs) by using <em>Rhododendron arboreum</em> flower extract, as well as evaluating their potential biomedical applications.</div></div><div><h3>Method</h3><div>X-ray diffraction, scanning electron microscopy, energy dispersive X-ray spectroscopy, ultraviolet-visible spectroscopy, and Fourier-transform infrared spectroscopy were used to characterize the α-Fe₂O₃ NPs synthesized from the <em>Rhododendron arboreum</em> flower extract.</div></div><div><h3>Results</h3><div>Comprehensive characterization of the synthesized α-Fe₂O₃ NPs revealed a hydrodynamic diameter of 274.7 nm and a zeta potential of −18.6 mV. X-ray diffraction analysis confirmed the formation of crystalline α-Fe₂O₃ with an average crystallite size of 32.03 nm. The nanoparticles exhibited potent antibacterial activity against <em>Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa,</em> and <em>Salmonella typhi</em>, with lower minimum inhibitory concentration and minimum bactericidal concentration values than the flower extract, thus indicating enhanced antimicrobial efficacy. Anti-inflammatory potential, assessed with egg albumin denaturation assays, indicated a significant decrease in inflammation. Furthermore, cytotoxicity evaluations in MCF-7 breast cancer cell lines indicated an IC₅₀ value of 22 μg/mL, suggesting promise for cancer therapy applications.</div></div><div><h3>Conclusion</h3><div>These findings highlight the successful green synthesis of α-Fe₂O₃ NPs with potential biomedical applications in antibacterial, anti-inflammatory, and anticancer treatments.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 5","pages":"Pages 737-750"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145333366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers to colorectal cancer screening tests among adults in the Saudi population: A systematic review and meta-analysis","authors":"Mohammed Aldakhil MD ,&nbsp;Raghad Ibrahim albarrak MD ,&nbsp;Rose khalaf Alharbi MD ,&nbsp;Yara Fahad Almazyad MD ,&nbsp;Rawan Khaled Alharbi MD ,&nbsp;Lama Abdullateef Albshry MD ,&nbsp;Layan Abdulaziz Altuwejri MD ,&nbsp;Dalia Abdulrhman Alammari MD ,&nbsp;Ghadah Abdulrahman Alsuhaibani MD","doi":"10.1016/j.jtumed.2025.09.001","DOIUrl":"10.1016/j.jtumed.2025.09.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Colorectal cancer (CRC) is the second most prevalent cancer in Saudi Arabia and the leading cause of gastrointestinal cancer-related mortality. Despite effective screening methods, participation remains low, resulting in delayed diagnoses and poor outcomes. Barriers include limited awareness, cultural beliefs, healthcare system constraints, and insufficient physician recommendations. Existing studies show variable findings, highlighting the need for a comprehensive synthesis.</div></div><div><h3>Objective</h3><div>To identify and categorize barriers to CRC screening in Saudi Arabia by examining individual, healthcare system, and sociocultural factors, and to provide recommendations for improving screening uptake.</div></div><div><h3>Methods</h3><div>A systematic search of PubMed, Embase, Google Scholar, the Saudi Digital Library, and the Cochrane Library was performed. Eligible studies examined barriers to CRC screening among Saudi adults using quantitative or qualitative methods. Non-Saudi, non-human, review, or methodologically unclear studies were excluded. Two independent reviewers conducted data extraction and quality assessment using ROBINS-I for observational studies and the Cochrane Risk of Bias Tool for RCTs. Heterogeneity was evaluated with Cochran’s Q and I², while publication bias was assessed using Begg’s test.</div></div><div><h3>Results</h3><div>Of 130 studies screened, 14 met the inclusion criteria. The most frequent barriers were lack of knowledge, absent physician recommendation, cultural stigma, gender-related concerns, and limited access. Meta-analysis revealed high heterogeneity (I² = 83.9%, p &lt; 0.001). Physician recommendation was the strongest predictor of participation, while stigma and access issues were key deterrents. No publication bias was detected (Begg’s test p = 0.296).</div></div><div><h3>Conclusion</h3><div>CRC screening in Saudi Arabia is hindered by multifactorial barriers. Targeted awareness, physician-driven initiatives, improved access, and culturally sensitive interventions are essential to enhance participation and reduce CRC mortality.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 5","pages":"Pages 654-662"},"PeriodicalIF":1.9,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health sector transformation in Saudi Arabia—The modern healthcare model: A qualitative study among healthcare leaders","authors":"Abeer Alharbi PhD ,&nbsp;Mohammed Aljuaid PhD ,&nbsp;Fahad A. Alamri MHA ,&nbsp;Shoroq N. Alosaimi MHA ,&nbsp;Sarah Aldeijy MHA","doi":"10.1016/j.jtumed.2025.08.006","DOIUrl":"10.1016/j.jtumed.2025.08.006","url":null,"abstract":"<div><h3>أهداف البحث</h3><div>هدفت هذه الدراسة إلى دراسة التغييرات في تقديم الرعاية الصحية في المملكة العربية السعودية وفقا لنموذج الرعاية الصحية الحديث، استنادا إلى وجهات نظر وتجارب قادة الرعاية الصحية، باستخدام نظرية التعقيد لفهم هذه التغييرات.</div></div><div><h3>طرق البحث</h3><div>استخدمت هذه الدراسة النوعية عينة هادفة من ثمانية مشاركين، والتي اعتُبرت كافية لتحديد المواضيع عبر البيانات. جُمعت البيانات من خلال مقابلات شبه مهيكلة بين أكتوبر 2024 وديسمبر 2024. تناولت الأسئلة تحديد خلفيات المشاركين وأدوارهم في المؤسسة؛ وعوامل تمكين وتحديات تطبيق نموذج الرعاية الصحية الحديث؛ والتغييرات التحولية الرئيسية في النظام الصحي؛ وآثار هذه التغييرات على السكان.</div></div><div><h3>النتائج</h3><div>تقدم هذه الدراسة خمسة محاور رئيسية ومحورا فرعيا واحدا مستمدا من تحليل شامل للبيانات. وشملت المحاور الرئيسية: تعزيز الصحة والوقاية من الأمراض؛ والحصول على الرعاية؛ والرعاية الافتراضية ورقمنة الرعاية الصحية؛ وكفاءة النظام وقيمته؛ والتغيير الثقافي. وكانت الرعاية الصحية الأولية والتكامل هي المحور الفرعي المنبثق عن المحور الرئيسي (الحصول على الرعاية).</div></div><div><h3>الاستنتاجات</h3><div>أشارت النتائج إلى أن نموذج الرعاية الصحية للأمهات، الذي يُركز على الوقاية، والحلول الرقمية، والرعاية الصحية الأولية، وتكافؤ الفرص، والانتقال السلس بين أنظمة الرعاية، قد أثر إيجابا على كفاءة النظام وقيمته. إضافة إلى ذلك، قد تواجه هذه التغييرات المستمرة في قطاع الرعاية الصحية العامة تحديات، لا سيما فيما يتعلق بالوعي العام ومقاومة التغيير.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 5","pages":"Pages 643-653"},"PeriodicalIF":1.9,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145061233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular docking and In-Silico pharmacokinetic analysis of 1,3-benzothiazole-2-amine derivatives as anticonvulsants","authors":"Ahmed Rufa’i MSc ,&nbsp;Abdullahi Y. Idris PhD ,&nbsp;Aliyu M. Musa PhD ,&nbsp;Halimatu S. Hassan PhD ,&nbsp;Asma’u H. Nasiru PhD ,&nbsp;Mohammed G. Magaji PhD","doi":"10.1016/j.jtumed.2025.08.002","DOIUrl":"10.1016/j.jtumed.2025.08.002","url":null,"abstract":"<div><h3>الأهداف</h3><div>تعتبر المشتقات التي تحمل مجموعة الثيازول من المواد الدوائية المهمة جدًا في الكيمياء الطبية نظرًا لخصائصها الدوائية الواسعة. البنزوثيازول هو سقالة مهمة مع مجموعة من النشاط البيولوجي والاستخدامات العلاجية، بما في ذلك خصائص مضادة للبكتيريا، ومضادة للملاريا، ومضادة للتشنجات، ومسكنة للألم، ومضادة للالتهابات، ومضادة لمرض السكري، ومضادة للسرطان. يقوم هذا العمل بتقييم السمات الدوائية الحركية الحاسوبية لـ 15 مشتقًا من 1،3-بنزوثيازول-2-أمين (نظائر) وتفاعلاتها مع هدفين أساسيين للصرع: حمض غاما أمينوبوتيريك-أمينوترانسفيراز (GABA-AT) وأيون الصوديوم المفتوح المنشط بروتينات القناة (Nav<em>Ms</em>).</div></div><div><h3>الطريقة</h3><div>تم تصميم وتحسين التركيب الكيميائي للمشتقات باستخدام برنامجي MarvinSketch و Spartan. تمت دراسة السمات الدوائية الحركية باستخدام خادم SwissADME. تم إجراء الالتحام الجزيئي باستخدام Autodock Vina وChimera وDiscovery Studio Visualizer</div></div><div><h3>النتائج</h3><div>فشلت أربعة نظائر (2، 5، 6، و7) في اختبار اختراق حاجز الدم الدماغي (BBB)، في حين أظهرت إحدى عشر من النظائر الخمسة عشر خصائص حركية دوائية جيدة. وأظهرت نتائج التحقق أن الإجراء المستخدم كان مناسبًا لتحليل الالتحام الجزيئي لنظائر الاختبار في المواقع النشطة للبروتينين المستهدفين. عند المقارنة مع الدواء المرجعي فيجاباترين (-5.2 كيلو كالوري/مول)، أظهرت سبعة نظائر (A₁، A₃، A₉، A₁₀، A₁₁، A₁₂، وA₁₄) تقارب ارتباط أعلى (-5.9، -5.8، -6.1، -5.9، -6.0، -6.1، و-6.6 كيلو كالوري/مول، على التوالي). ربط GABA-AT. فيما يتعلق بربط NavMs، أظهر A14 التناظري فقط تقاربًا للربط يبلغ 5.0 كيلو كالوري/مول، وهو ما كان مماثلاً لذلك الخاص بالدواء المرجعي، لاموتريجين.</div></div><div><h3>الاستنتاجات</h3><div>كشفت التحقيقات الحاسوبية عن مركبات بنزوثيازول ذات خصائص مضادة للتشنج عالية، مما يجعلها مرشحة مناسبة للتوليف والاختبار الدوائي.</div></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":"20 5","pages":"Pages 629-642"},"PeriodicalIF":1.9,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}