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Acupuncture treatment for sleep disturbances patients: A case report with inflammatory cytokine levels evaluation 针刺治疗睡眠障碍患者:1例炎症细胞因子水平评估报告
Pub Date : 2018-01-01 DOI: 10.21767/AMJ.2017.3304
Y. Kim
Sleep disturbance is one of the more common risk factors, numerous other negative physical health outcomes, and it is defined as self-reported poor quality of sleep, short sleep duration, daytime sleepiness, and insomnia symptoms. It is a common risk factor for depression and anxiety. Here, a case of sleep disturbance that received 72 sessions of acupuncture treatment delivered is reported. After acupuncture treatment, the patient’s PSQI, HDRS, and SAS score decreased, as well as the plasma TNF-α, and IL-6 being reduced. No adverse effects were observed. The clinical studies findings provide evidence supporting the acupuncture aimed at the cause of sleep disturbance symptoms can also be useful.
睡眠障碍是较常见的风险因素之一,还有许多其他负面的身体健康结果,它被定义为自我报告的睡眠质量差、睡眠时间短、白天嗜睡和失眠症状。这是导致抑郁和焦虑的常见风险因素。本文报道了一例接受72次针灸治疗的睡眠障碍患者。针刺治疗后,患者PSQI、HDRS、SAS评分下降,血浆TNF-α、IL-6降低。未观察到不良反应。临床研究结果提供了证据,支持针灸针对睡眠障碍症状的原因也可以是有用的。
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引用次数: 0
Clinical insights on Tolosa Hunt syndrome: A multidisciplinary approach on neurological-related symptomatology in maxillofacial region Tolosa Hunt综合征的临床观察:颌面部神经相关症状学的多学科方法
Pub Date : 2018-01-01 DOI: 10.21767/AMJ.2018.3351
Z. Khan, Ammar Ahmed Siddiqui, J. Syed, Hamoud Aziz Alanizy, A. Cicconetti, A. Orefici, G. Falisi, F. Inchingolo, P. Bollero
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引用次数: 0
Splenectomy in non-traumatic diseases 脾切除术在非创伤性疾病中的应用
Pub Date : 2018-01-01 DOI: 10.21767/amj.2018.3386
C. Gomes, Cléber Soares Júnior, F. Coccolini, G. Montori, Alice Assumpção Soares, Celio Pereira Junior, Flavio Vieira Marques Filho, P. Mendonca, Felipe Couto Gomes
Splenectomy represents the first choice for treatment of spontaneous splenic rupture, abscesses, cysts, tumours, and an alternative for control of hereditary, autoimmune, and myeloproliferative disorders. However, its relative indications have been reviewed for better understanding of both the primary affections and of splenectomy per se, particularly with regard to the immune system. The emergence of minimally invasive surgery, the possibility of splenic preservation, and availability of biological therapy has shown that the procedure has often been referred to as salvage therapy upon failure of other therapeutic propositions. On the other hand, patients have their general health status compromised by the underlying disease, by the use corticosteroids or biologic therapy, immunosuppressed, coagulation disorders, which contribute to the incidence of postoperative complications, such as infections, bleeding and venous thrombosis. Therefore, this scenario favours higher morbidity and mortality rates than those of other intra-abdominal surgical procedures. Thus, this review has the primary and comprehensive objective of purpose the best moment for splenectomy, when surgeons can interfere in the natural course of the disease increasing patients’ quality of life and survival. In short, it is desired that the surgeon has complete knowledge of the profound physiological changes imposed on the host. In addition, to distinguish when it is curative and mandatory from when it must be put on hold due to other non-operative treatments with similar outcomes and, lastly, when it is not recommended for not aggregating survival.
脾切除术是治疗自发性脾破裂、脓肿、囊肿、肿瘤的首选,也是控制遗传性、自身免疫性和骨髓增生性疾病的一种选择。然而,为了更好地了解脾切除术的原发影响和脾切除术本身,特别是对免疫系统的影响,我们对其相关适应症进行了综述。微创手术的出现、脾脏保存的可能性以及生物治疗的可用性表明,在其他治疗方案失败后,该程序通常被称为挽救性治疗。另一方面,患者的总体健康状况因潜在疾病、使用皮质类固醇或生物治疗、免疫抑制、凝血功能障碍而受到损害,这有助于发生术后并发症,如感染、出血和静脉血栓形成。因此,这种情况下的发病率和死亡率高于其他腹内外科手术。因此,本综述的主要目的是探讨脾切除术的最佳时机,此时外科医生可以干预疾病的自然进程,提高患者的生活质量和生存率。简而言之,希望外科医生完全了解施加在宿主身上的深刻生理变化。此外,要区分什么时候它是治愈性和强制性的,什么时候它必须搁置,因为其他非手术治疗有类似的结果,最后,当不建议不聚集生存。
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引用次数: 2
Neuron- specific enolase level in patients with metabolic syndrome and its value forecasting acute stroke 代谢综合征患者神经元特异性烯醇化酶水平及其对急性卒中的预测价值
Pub Date : 2018-01-01 DOI: 10.21767/AMJ.2018.3353
O. Ospanov, K. Ospanova, I. Kadyrova
Background Patients with metabolic syndrome are at a greater risk of experiencing a cerebrovascular event. Several studies show that patients with metabolic syndrome have asymptomatic ischemic brain injury. In this case, there is a need for rapid determination of asymptomatic brain lesions and prediction of acute stroke. Aims The aim of the study was to determine the neuron-specific enolase (NSE) serum level in patients with metabolic syndrome and the value of this level for forecasting acute stroke. Methods The study used the following information to determine metabolic syndrome: waist circumference, total cholesterol, triglycerides, high-density lipoprotein cholesterol, blood pressure, and blood glucose. Doppler sonography mapping of the brachiocephalic trunk was held to determine the percentage of the carotid artery stenosis. To determine asymptomatic ischemic brain injury, the NSE serum marker was measured. Statistical processing of the measurements was performed using the H test and the Mann–Whitney test. The possible link between MS and NSE were determined by logistic regression analysis. Mathematical modeling was performed using logistic regression. Results There are statistically significant differences in NSE concentrations in groups with metabolic syndrome and ischemic stroke patients. This assertion is confirmed by logistic regression analysis, which revealed the existence of a relationship between metabolic syndrome and increased concentration of NSE. Conclusion Patients with metabolic syndrome have an increased concentration of NSE. This indicates the presence of asymptomatic ischemic neuronal damage. A prognostic model for determining the probability that patients with metabolic syndrome will have an acute stroke was developed.
背景:代谢综合征患者发生脑血管事件的风险较大。多项研究表明,代谢综合征患者存在无症状缺血性脑损伤。在这种情况下,有必要快速确定无症状的脑损伤和预测急性中风。目的研究代谢综合征患者血清神经元特异性烯醇化酶(NSE)水平及其对急性脑卒中的预测价值。方法采用以下信息测定代谢综合征:腰围、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、血压和血糖。对头臂干进行多普勒超声成像,以确定颈动脉狭窄的百分比。测定NSE血清标志物以确定无症状缺血性脑损伤。采用H检验和Mann-Whitney检验对测量结果进行统计处理。通过logistic回归分析确定MS与NSE之间可能存在的联系。采用逻辑回归进行数学建模。结果代谢综合征组与缺血性脑卒中组NSE浓度差异有统计学意义。逻辑回归分析证实了这一论断,揭示了代谢综合征与NSE浓度升高之间存在关系。结论代谢综合征患者NSE浓度升高。这表明存在无症状缺血性神经元损伤。开发了一种用于确定代谢综合征患者发生急性中风的概率的预后模型。
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引用次数: 5
Bilateral complete ureteral duplication with fixed dumbbell stone formation in the ureterocele 双侧输尿管完全复制伴输尿管囊肿内固定哑铃状结石形成
Pub Date : 2018-01-01 DOI: 10.21767/amj.2018.3366
S. Vahidi, P. Shadpour, N. Narimani, S. Haghdani
Bilateral ectopic ureteroceles are extremely rare. There are few reports of bilateral duplex system with ureterocele stone formation. Our case report represents a 35-year-old woman with bilateral complete ureteral duplication and stone in a right sided ureterocele. A Bugbee electrode was used to puncture the ureterocele at its most dependent part followed by fragmenting the stone using pneumatic lithotripsy. Management of the ureterocele stone depends mostly on stone size. Whereas smaller stones are amenable to endoscopic incision and lithotripsy, larger ones have required combination therapy with endoscopic incision, laser or pneumatic lithotripsy and even orificiotomy and ureterolithotomy.
双侧异位输尿管囊肿极为罕见。双侧双系统合并输尿管囊肿结石的报道很少。我们的病例报告是一位35岁的女性,患有双侧输尿管完全复制和右侧输尿管囊肿结石。使用Bugbee电极在输尿管囊肿最依赖的部分穿刺,然后使用气压碎石粉碎结石。输尿管囊肿结石的处理主要取决于结石的大小。较小的结石可行内镜下切开碎石,而较大的结石则需要联合内镜下切开、激光或气压碎石,甚至开口和输尿管切开碎石。
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引用次数: 0
Sinus histiocytosis with massive lymphadenopathy, (Rosai-Dorfman Disease) with cholastatic jaundice in an HIV positive patient 窦性组织细胞增多症伴大量淋巴结病变,(Rosai-Dorfman病)伴胆汁淤积性黄疸
Pub Date : 2018-01-01 DOI: 10.21767/amj.2018.3456
K. Mpho, Elnagar Ali Ahmed, Mashoshoe Kgataki Sam, T. Preetha, Ngwata Portia, Bida Mishack
Introduction Sinus histiocytosis with massive lymphadenopathy is a rare histiocytic disease first described by Rosai and Dorfman in 1969. The typical presentation is that of cervical and often widespread painless lymphadenopathy. Case report We present a 33-year-old gentleman, with one-month history of pruritus, abdominal pain, jaundice and dark urine, jaundice, scratch marks, large inguinal lymph nodes, an enlarged liver and spleen. CT scan confirmed ultrasound findings and suggested that splenic lesions were microabscesses. Biopsy of the lymph nodes revealed features in keeping with sinus histiocytosis with dermatophatic lymphadenopathy. Discussion This is our second case of sinus histiocytosis in two years.
窦性组织细胞增多症合并大量淋巴结病是一种罕见的组织细胞疾病,由Rosai和Dorfman于1969年首次报道。典型的表现是颈部无痛性淋巴结病,通常分布广泛。我们报告一位33岁的男性患者,有瘙痒、腹痛、黄疸及尿色深、黄疸、抓痕、腹股沟淋巴结大、肝脾肿大等病史一个月。CT扫描证实超声表现,提示脾病变为微脓肿。淋巴结活检显示的特征与皮肤淋巴病变的窦性组织细胞增多症一致。这是我们两年内第二例窦性组织细胞增多症。
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引用次数: 0
Systems multiple molecule drug design with less side-effects via drug data mining and genome-wide data identification 通过药物数据挖掘和全基因组数据识别,系统设计副作用小的多分子药物
Pub Date : 2018-01-01 DOI: 10.21767/amj.2018.3439
Bor-Sen Chen
Background Drugs fail in the clinic for two main reasons; one is that they do not work and another is that they are not safe. As such, two of the most important steps in developing new drugs should be drug targets identification and side-effect validation. Aims The identification of drug targets and their restoration of cellular dysfunctions to normal cellular functions with less side-effects are considered as drug design specifications of systems medicine discovery. Since the effect on the normal expression of house-keeping genes and proteins is also considered as a restriction on drug design, the proposed multi-molecules drug strategy might be helpful for systems drug design with less-side effects. Methods By systems biology method, genetic and epigenetic networks (GENs) are constructed to identify network biomarker for drug targets of diseases by genome-wide high throughput data. An integration of computational networkbased approach for multiple drug targets with drug data mining is also proposed for systems drug discovery with more precise medicine and less side-effects. Finally, some systematic drug design specifications for drug design are proposed to restore to the normal functions of multiple drug targets with less side-effects. Results A systematic method is introduced to find multiple drug targets based on pathogenic mechanism investigated by network identification through genome-wide highthroughput data. Then a multi-molecule drug design strategy is also proposed to select a set of multi-molecule drugs with less side-effects via drug data mining method. Conclusion Systematic engineering design methods seem applicable to systems drug discovery and design.
药物在临床上失败主要有两个原因;一个是它们不起作用,另一个是它们不安全。因此,开发新药的两个最重要的步骤应该是药物靶点识别和副作用验证。目的确定药物靶点并使细胞功能障碍恢复到正常细胞功能,减少副作用是系统医学发现的药物设计规范。由于对看家基因和蛋白质正常表达的影响也被认为是药物设计的限制因素,因此提出的多分子药物策略可能有助于副作用较小的系统药物设计。方法采用系统生物学方法,构建遗传和表观遗传网络(GENs),利用全基因组高通量数据识别疾病药物靶点的网络生物标志物。本文还提出了一种基于计算网络的多靶点药物数据挖掘方法,用于更精确的药物发现和更少的副作用。最后,提出了一些系统的药物设计规范,以恢复多个药物靶点的正常功能,减少副作用。结果介绍了一种基于全基因组高通量数据的网络鉴定研究致病机制的多药物靶点寻找系统方法。然后提出了一种多分子药物设计策略,通过药物数据挖掘方法选择一组副作用较小的多分子药物。结论系统工程设计方法适用于系统药物的发现和设计。
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引用次数: 1
Barriers to support nurses as second victim of medical errors: A qualitative study 支持护士作为医疗事故第二受害者的障碍:一项定性研究
Pub Date : 2018-01-01 DOI: 10.21767/amj.2018.3515
Z. Mokhtari, M. Hosseini, H. Khankeh, M. Fallahi-khoshknab, A. N. Nasrabadi
Background Given the inevitability of medical errors and their impact on health workers, providing support to those who suffer is vital for their physical and mental recovery. Identifying the barriers to obtaining support is imperative in this regard. Aims The current study was conducted to identify the barriers regarding supporting nurses as second victims of nursing errors in clinical settings in Iran. Methods This qualitative study was conducted with a sample, which was included 18 nurses. The subjects were selected through the purposive sampling method, and data were collected using in-depth and semi-structured interviews. The data were analysed using methods as described by Graneheim and Lundman (citation needed). The research context included the general and specialized departments of hospitals in Tehran, Iran, during 2017. Results According to the results, mismanagement, Cultural barriers, inadequate information, and Legal barriers were the main barriers to supporting nurses. Conclusion Training nurses about the second victim phenomenon is recommended as well as the methods to manage the effects of this phenomenon, the supportive resources, and legal issues.
鉴于医疗差错的不可避免性及其对卫生工作者的影响,为受害者提供支持对他们的身心康复至关重要。在这方面,确定获得支助的障碍是必要的。目前的研究旨在确定伊朗临床环境中护士作为护理失误的第二受害者的障碍。方法对18名护士进行定性研究。采用目的抽样法选择研究对象,采用深度访谈和半结构化访谈法收集数据。使用Graneheim和Lundman描述的方法分析数据(需要引证)。研究背景包括2017年伊朗德黑兰医院的综合科和专科。结果结果显示,管理不善、文化障碍、信息不足和法律障碍是支持护士的主要障碍。结论建议对护士进行二次受害现象的培训,并对该现象的影响、支持资源和法律问题进行管理。
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引用次数: 4
Updated meta-analysis of the relation between heart disease and androgenic alopecia or alopecia areata 心脏病与雄激素性脱发或斑秃关系的最新meta分析
Pub Date : 2018-01-01 DOI: 10.21767/amj.2017.3270
M. Amamoto, Tomohide Yamada, K. Hara
Background The relationship between baldness and heart disease is still controversial. We performed an updated meta-analysis of observational studies to evaluate the relation between heart disease and androgenic alopecia or alopecia areata. Aims To evaluate the relation between heart disease and androgenic alopecia or alopecia areata. Methods Studies were identified by searching Medline and Embase up to October 20, 2017 without language restriction. Metaanalysis was performed by using a random-effects model. Results Nine studies were included in the meta-analysis (eight on androgenic alopecia and one on alopecia areata: 44,806 participants). Compared to men without baldness, men with androgenic alopecia had an increased risk of heart disease (relative risk (RR): 1.32, 95 per cent CI: 1.08 to 1.63, p=0.01, I 2 =25 per cent), and younger men (<55 or ≤60 years) showed a stronger association (RR: 1.44, 95 per cent CI: 1.11 to 1.86, p=0.01, I 2 =0 per cent). The positive relation depended on the severity of baldness and decreased in order of severe vertex (RR: 1.60, 95 per cent CI: 1.19 to 2.16, p=0.002), moderate vertex (RR: 1.41, 95 per cent CI: 1.22 to 1.64, p<0.001), mild vertex (RR: 1.18, 95 per cent CI: 1.05 to 1.33, p=0.007), and frontal baldness (RR: 1.10, 95 per cent CI: 0.92 to 1.32, p=0.28)). In contrast, there was no significant relation between alopecia areata and heart disease (RR: 0.91, 95 per cent CI: 0.60 to 1.39, p=0.66).
秃顶与心脏病之间的关系仍然存在争议。我们对观察性研究进行了最新的荟萃分析,以评估心脏病与雄激素性脱发或斑秃之间的关系。目的探讨心脏疾病与雄激素性脱发或斑秃的关系。方法通过Medline和Embase检索到2017年10月20日的研究,不受语言限制。采用随机效应模型进行meta分析。荟萃分析包括9项研究(8项关于雄激素性脱发,1项关于斑秃:44,806名参与者)。与没有秃顶的男性相比,雄激素性脱发的男性患心脏病的风险增加(相对风险(RR): 1.32, 95% CI: 1.08至1.63,p=0.01, i2 = 25%),年轻男性(<55或≤60岁)表现出更强的相关性(RR: 1.44, 95% CI: 1.11至1.86,p=0.01, i2 = 0%)。这种正相关关系取决于秃顶的严重程度,并依次递减:严重秃顶(RR: 1.60, 95% CI: 1.19 ~ 2.16, p=0.002)、中度秃顶(RR: 1.41, 95% CI: 1.22 ~ 1.64, p<0.001)、轻度秃顶(RR: 1.18, 95% CI: 1.05 ~ 1.33, p=0.007)、额顶(RR: 1.10, 95% CI: 0.92 ~ 1.32, p=0.28)。相比之下,斑秃与心脏病之间没有显著关系(RR: 0.91, 95% CI: 0.60 ~ 1.39, p=0.66)。
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引用次数: 4
The effects of aerobic exercise on cognitive performance and sleep quality haemodialysis patients 有氧运动对血液透析患者认知表现和睡眠质量的影响
Pub Date : 2018-01-01 DOI: 10.21767/AMJ.2017.3279
Leila Poorsaadet, P. Soltani, K. Ghassami, B. Kohansal, M. Ahmadlou
Background Cognitive impairment and sleep disturbance are very common in chronic kidney disease (CKD) and are strongly associated with increased mortality among the patients. Even though, exercise is considered to be a quantifiable activity that improves cognition in animals and humans, but few studies have examined the efficacy of exercise on cognitive function and sleep quality in CKD.
背景认知障碍和睡眠障碍在慢性肾脏疾病(CKD)中非常常见,并且与患者死亡率增加密切相关。尽管运动被认为是一种可量化的活动,可以改善动物和人类的认知能力,但很少有研究调查运动对CKD患者认知功能和睡眠质量的影响。
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引用次数: 3
期刊
Australasian Medical Journal
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