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Definitive treatment of a basal cell carcinoma on the upper lip through the oral administration of Vismodegib 通过口服维莫德吉的上唇基底细胞癌的最终治疗
Pub Date : 2018-01-01 DOI: 10.21767/AMJ.2017.3273
S. Strashilov, V. Kirov, A. Yordanov, V. Nanev, I. Iliev, Emil Petkov
Basal cell carcinoma is the most common malignant neoplasm of the skin of the face in old, caucasian humans. The tumour growth slow and rarely has metastases. The clinical presentation is different. The main method for treating is radical surgical excision, but if the tumour is very big or there are metastases, there is a very effective target therapy with the peroral capsules Vismodegib 150mg. In this case we introduce a patient whit cancer of upper lip of preoperative target therapy whit Vismodegib 150mg, which destroy the tumour cells and help us to make cosmetic surgical excision.
基底细胞癌是老年白种人面部皮肤最常见的恶性肿瘤。肿瘤生长缓慢,很少发生转移。临床表现不同。治疗的主要方法是根治性手术切除,但如果肿瘤很大或有转移,则有一个非常有效的靶向治疗方法,即口服Vismodegib胶囊150mg。在这个案例中,我们介绍了一个患者的上唇癌的术前靶向治疗白色Vismodegib 150mg,它破坏肿瘤细胞,帮助我们做美容手术切除。
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引用次数: 0
Primary malignant melanoma of the vagina in a postmenopausal woman 绝经后妇女阴道的原发性恶性黑色素瘤
Pub Date : 2018-01-01 DOI: 10.21767/AMJ.2017.3296
H. Y. Ahn, Jin Wan Park, Jong-Soo Kim
Primary malignant melanoma of the vagina, a very rare malignancy, is very aggressive and highly metastatic. Primary vaginal melanoma usually has a poor clinical prognosis, because it is often diagnosed at an advanced stage. We present a case of an 80-year-old postmenopausal woman with pigmented lesion of the vagina. The histopathology of the lesion revealed malignant melanoma. The patient was treated surgically, with wide local excision of the vaginal lesion. Left inguinal lymphadenectomy, based on the positron emission tomography-computed tomography (PET-CT) images, found metastatic melanoma. We present a case report of postmenopausal woman with primary vaginal melanoma.
阴道原发性恶性黑色素瘤是一种非常罕见的恶性肿瘤,具有很强的侵袭性和高度转移性。原发性阴道黑色素瘤的临床预后通常很差,因为它通常在晚期才被诊断出来。我们提出了一个80岁的绝经后妇女与阴道色素病变的情况。病变组织病理显示为恶性黑色素瘤。患者接受手术治疗,广泛局部切除阴道病变。左侧腹股沟淋巴结切除术,基于正电子发射断层扫描-计算机断层扫描(PET-CT)图像,发现转移性黑色素瘤。我们提出一个病例报告绝经后妇女原发性阴道黑色素瘤。
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引用次数: 1
Evaluating antimicrobial resistance patterns of the etiological agents of urinary tract infections 评价尿路感染病原菌的耐药模式
Pub Date : 2018-01-01 DOI: 10.21767/AMJ.2018.3310
D. Hisham, O. Safdar, M. Shalaby, Mohammed Sabbahi, Mowadah Ashgar, R. Shafi, Dina Binmahfoodh, D. Khizindar
Background Antimicrobial resistance has been presented as a highly prevailing condition. Aims To evaluate antimicrobial resistance patterns of the etiological agents of urinary tract infection among children in Saudi Arabia. Methods A retrospective population-based epidemiological study has been conducted at King Abdulaziz University Hospital, Saudi Arabia, from the year 2016–2017. It has recruited individuals with clinical diagnosis of urinary tract infection, particularly. Results The study has recruited 63 participants on the basis of inclusion criteria. Among these, majority were males with the prevalence of 54 per cent (n=34); while females were 46 per cent (n=29). Most of the participants were under the age of two years with the prevalence of 50.8 per cent (n=32), then children of 2 years with 34.9 per cent (n=22); and older than two years with 14.3 per cent (n=9). Resistance to ampicillin was observed in 12.7 per cent cases; resistance to ciprofloxacin was observed in 1.6 per cent; resistance to cotrimoxazole was witnessed in 3.2 per cent; and multidrug resistance was observed in 30.2 per cent of the patients. Conclusion Clinical management of urinary tract infections is a challenge that mainly presents antimicrobial resistance as the point of concern.
抗菌素耐药性已成为一种高度普遍的疾病。目的了解沙特阿拉伯儿童尿路感染病原菌的耐药情况。方法2016-2017年在沙特阿拉伯阿卜杜勒阿齐兹国王大学医院进行回顾性人群流行病学研究。它招募了临床诊断为尿路感染的个体,特别是。结果根据纳入标准,本研究共招募了63名受试者。其中大多数为男性,患病率为54% (n=34);而女性占46% (n=29)。大多数参与者为2岁以下,患病率为50.8% (n=32),其次为2岁儿童,患病率为34.9% (n=22);两岁以上的占14.3% (n=9)。12.7%的病例对氨苄西林耐药;对环丙沙星耐药1.6%;对复方新诺明的耐药性为3.2%;多药耐药率为30.2%。结论尿路感染的临床管理是一个挑战,主要表现为抗菌药物耐药性。
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引用次数: 1
Evaluation of sensitivity and the specificity of Canadian CT head rule and New Orleans criteria in patients with head injury 评价加拿大CT头部规则和新奥尔良标准对颅脑损伤患者的敏感性和特异性
Pub Date : 2018-01-01 DOI: 10.21767/AMJ.2018.3328
Nasim Chobdari, M. Sharifi, B. Kakhki, S. Shamsaei, Hamideh Feiz Disfani, A. Hashemian
Background Millions of people around the world are annually under emergency investigation due to severe head injuries. Computed tomography (CT) scans is a diagnostic procedure that can be done for most people.
世界各地每年有数百万人因严重头部损伤而接受紧急检查。计算机断层扫描(CT)是一种诊断程序,可以为大多数人做。
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引用次数: 1
Pulmonary hydatidosis patterns and clinical outcomes 肺包虫病的模式和临床结果
Pub Date : 2018-01-01 DOI: 10.21767/AMJ.2018.3345
S. Hamouri, A. R. A. Manasra, Hamzah Daradkeh, H. Hammouri, Nabil Al zoubi, N. Novotny
Background Pulmonary hydatidosis remains a significant health problem in endemic areas. The clinical patterns and presentation vary according to the size, number, location and integrity of the cyst. Aims The aim of this study is to retrospectively evaluate the pattern and outcomes of patients diagnosed with pulmonary hydatidosis treated surgically in a tertiary hospital in northern Jordan. Methods A retrospective review of patients with pulmonary hydatidosis between December 2009 and December 2017 were performed. Data regarding demographic features, clinical presentation, serology testing, clinical outcomes and duration of medical treatment after surgery were obtained. Chest X-Ray and computerized tomography as well as liver ultrasound were the main methods of diagnosis. Parenchyma preserving excisions of the laminated membrane with capitonnage of the remaining cavity were performed in all patients. Albendazole was prescribed for 3– 6 months postoperatively. Results Eighty-eight patients were involved. Mean age was 29.5±16.7 years (range 8–75). Females comprised 52 per cent of the patients. The main presenting symptoms were cough, dyspnea and chest pain. Thirty-two (37 per cent) patients had rupture of the cyst at the time of the presentation; 15 patients had direct rupture, 10 had communicating rupture and contained rupture was diagnosed in seven patients. Multiple and/or bilateral lesions were encountered in 25/88 (28.5 per cent) and 15 (17 per cent) patients respectively. Lower lobes were involved in 73.8 per cent of the cases. The mean hospital stay was 6.53±2.83 days. Post-operative morbidities were developed in 12/88 (13 per cent) patients with air leak (5 per cent) as the most common morbidity. No recurrences or mortalities were reported in the follow up period. Conclusion Parenchyma preserving cyst excision with capitonnage provides a low postoperative morbidity in patients with both intact and complicated pulmonary hydatidosis. To decrease the risk of recurrence albendazole treatment is indicated postoperatively especially for recurrent, complicated and multiple hydatid cysts.
背景肺包虫病在流行地区仍然是一个重要的健康问题。根据囊肿的大小、数量、位置和完整性不同,其临床表现也不同。目的本研究的目的是回顾性评价约旦北部一家三级医院诊断为肺包虫病的患者手术治疗的模式和结果。方法对2009年12月至2017年12月收治的肺包虫病患者进行回顾性分析。获得了有关人口统计学特征、临床表现、血清学检测、临床结果和手术后治疗时间的数据。胸部x线、计算机断层扫描及肝脏超声是诊断的主要方法。所有患者均行保留实质的层压膜切除,保留腔体。术后3 - 6个月开阿苯达唑。结果共88例患者。平均年龄29.5±16.7岁(8 ~ 75岁)。女性占病人总数的52%。主要表现为咳嗽、呼吸困难、胸痛。32例(37%)患者在出现症状时囊肿破裂;直接破裂15例,沟通破裂10例,包涵破裂7例。多发性和/或双侧病变分别在25/88(28.5%)和15(17%)患者中出现。73.8%的病例累及下肺叶。平均住院时间为6.53±2.83天。术后发病率为12/88(13%),最常见的发病率为漏气(5%)。随访期间无复发或死亡报告。结论保留肺实质囊肿包膜切除对完整及并发肺包虫病均有较低的术后发病率。为降低复发风险,术后尤其对复发性、复杂性和多发包虫病应给予阿苯达唑治疗。
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引用次数: 2
Kindness and competition: Are we striking the right balance in medical education? 善良与竞争:我们是否在医学教育中取得了正确的平衡?
Pub Date : 2018-01-01 DOI: 10.21767/AMJ.2018.3440
D. Brewster, C. Rees, M. Leech, Geoffrey Thompson
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引用次数: 1
Complexity problem in immunology 免疫学中的复杂性问题
Pub Date : 2018-01-01 DOI: 10.21767/amj.2018.3490
V. Zemskov, K. Pronko, A. Zemskov, V. Zemskova
The article discusses the problem of immune response complexity, found in functional unity of regulatory systems, cooperation of immunocompetent cells, connection and regulation of specific and non-specific defence mechanisms, association of immune, routine laboratory and clinical parameters under normal and pathological conditions. The article reviews the influence of disease combinations, their comprehensive treatment on immunopathology, and the corrector effects. To reproduce natural mechanisms of homeostasis regulation, complex, blocking immunotherapy of diseases is suggested.
本文讨论了调节系统的功能统一、免疫活性细胞的协同、特异性和非特异性防御机制的联系和调节、正常和病理条件下免疫、常规实验室和临床参数的关联等方面存在的免疫反应复杂性问题。本文就疾病组合及其综合治疗对免疫病理的影响及纠正作用进行综述。为了再现体内平衡调节的自然机制,建议对疾病进行复杂的、阻断的免疫治疗。
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引用次数: 1
Public knowledge and awareness of the effect of diabetes mellitus on oral health 公众对糖尿病对口腔健康影响的认知和意识
Pub Date : 2018-01-01 DOI: 10.21767/AMJ.2018.3523
A. Mubayrik, Aseel Al Mutairi, H. A. Mutairi, Aljoharah Bin Osseil, Norah Al Shahwan, Hanan Al Sohaibani, E. Hadlaq, H. Albagieh
Abstract Background Diabetes mellitus (DM) is a common chronic disease with an increasing prevalence, affecting general and oral health, with several oral manifestations. A bidirectional effect of diabetes and periodontal diseases has been reported by many researchers. Aim This study aimed to evaluate public awareness and knowledge of the association between DM and oral health among public living in Saudi. Methods A cross-sectional survey was done in Saudi Arabia to determine knowledge, attitudes, and awareness to assess public regarding knowledge of DM-related oral health. Questionnaire was designed and distributed in local Language to a convenient sample group through social media outlets. Results One hundred-ninety completed questionnaires. Our study findings indicated a general awareness of the association between DM and oral health but demonstrated a lack of awareness concerning some oral diseases related with DM. 134 out 190 participants (70.5 per cent) of the respondents confirmed that DM had a negative effect on oral health, and 46.9 per cent considered periodontal disease to have a negative effect on glycemic control. There was a reasonable knowledge concerning DM-related oral manifestations. In contrast, one third of the respondents considered it possible to treat patients with DM and with a blood glucose below 3.9 mmol/Which indicated that they think a low blood glucose level has good prognosis and 43.7 per cent agreed that patients with DM should take antibiotics after tooth extraction, while 33.7 per cent of respondents agreed that antibiotics should be administered prior to tooth extraction. These are important considerations for early diagnosis and onset management of oral disease. Conclusion These findings indicate the need for targeted and specific health information education. They also support a greater need for collaboration between physicians and dentists.
背景糖尿病(DM)是一种常见病,发病率不断上升,影响全身健康和口腔健康,有多种口腔表现。许多研究人员已经报道了糖尿病和牙周病的双向作用。目的本研究旨在评估沙特公众对糖尿病与口腔健康之间关系的认识。方法在沙特阿拉伯进行横断面调查,以确定公众对糖尿病相关口腔健康知识的了解、态度和意识。问卷以当地语言设计,并通过社交媒体分发给方便的样本群体。结果共完成问卷190份。我们的研究结果表明,人们普遍意识到糖尿病与口腔健康之间的关系,但对与糖尿病相关的一些口腔疾病却缺乏认识。190名参与者中有134人(70.5%)确认糖尿病对口腔健康有负面影响,46.9%的人认为牙周病对血糖控制有负面影响。对dm相关的口腔表现有合理的了解。相比之下,三分之一的应答者认为血糖低于3.9 mmol/的糖尿病患者可以治疗,这表明他们认为低血糖水平预后良好,43.7%的应答者同意糖尿病患者在拔牙后应服用抗生素,而33.7%的应答者同意在拔牙前应服用抗生素。这些是口腔疾病早期诊断和发病管理的重要考虑因素。结论有针对性、针对性地开展健康信息教育。它们还支持医生和牙医之间更大的合作需求。
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引用次数: 3
Complicated giant perianal condylomata accuminata transforming into squamous cell carcinoma in a patient with latent syphilis 潜伏性梅毒患者并发巨大肛周尖锐湿疣转化为鳞状细胞癌
Pub Date : 2018-01-01 DOI: 10.21767/AMJ.2018.3527
Redha Issa Al Lawati, Ibrahim Al-Busaidi
Giant condylomata accuminata (CA) is a pre-malignant tumour, which commonly involves the genital area. Human papilloma virus (HPV) 6 and 11 are the most common causative pathogens for this rapidly growing tumour. (CA) has been also associated with human immunodeficiency virus (HIV) infection, 40 to 60 per cent of benign (CA) transforms to malignancy. The main risk factors for HPV infection and subsequently condylomata include risky sexual behaviours, early pregnancy and tobacco use. Here, we report a 55-year-old man who presented with complicated giant perianal (CA) that transformed into squamous cell carcinoma. His condition was complicated by recurrent infections and massive bleeding. The patient underwent end colostomy followed by surgical resection of the mass followed by palliative radiotherapy. Histopathological analysis of the resected mass confirmed transformation into squamous cell carcinoma. Malignant transformation of (CA) should be suspected in patients with rapidly enlarging perianal mass and progressively invasive disease.
巨大尖锐湿疣(CA)是一种恶性前肿瘤,通常累及生殖器区域。人类乳头瘤病毒(HPV) 6和11是这种快速生长的肿瘤最常见的致病病原体。(CA)也与人类免疫缺陷病毒(艾滋病毒)感染有关,40%至60%的良性(CA)转化为恶性。HPV感染和随后尖锐湿疣的主要危险因素包括危险的性行为、早孕和吸烟。在这里,我们报告一位55岁的男性,他表现出复杂的巨大肛周(CA)转化为鳞状细胞癌。他的病情因反复感染和大出血而变得复杂。患者行结肠造口术,手术切除肿块,再行姑息性放疗。切除肿块的组织病理学分析证实为鳞状细胞癌。恶性转化(CA)应怀疑患者迅速扩大的肛周肿块和进行性侵袭的疾病。
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引用次数: 0
Remedies in asthma treatment: Introduce a new remedy from perspective of Persian medicine 治疗哮喘的偏方:从波斯医学的角度介绍一种新的偏方
Pub Date : 2018-01-01 DOI: 10.21767/AMJ.2017.3245
M. Emtiazy, Laleh Oveidzadeh, M. Habibi, Z. Jafari, M. Kamalinejad
Background Asthma is a chronic inflammatory disease of the airways. Mucus plug formation, oxidative stress, swelling of the airway walls, inflammatory process and vascular changes are important events in asthma pathogenesis. Aims Although bronchodilators and steroids are two main drugs in asthma treatment, many adults and children still use complementary and alternative (CAM) medicine. This study was conducted to determine the most popular remedies in asthma treatment from perspective of Traditional Persian medicine (TPM) manuscripts. Methods The main Traditional Persian textbooks from the 9th to 18th centuries AD were collected and analysed. Thereafter, the most listed plants in asthma treatment were gathered. The plants in this list were searched and compared in recent studies. Results Some of these plants have antiinflammatory and antioxidant effects; a few of them have undergone animal or human researches in conventional medicine. Conclusion According to long history of medicine in Persia the collected list of remedies could be helpful in selecting plants for future studies in asthma treatment.
哮喘是一种慢性气道炎症性疾病。粘液塞形成、氧化应激、气道壁肿胀、炎症过程和血管改变是哮喘发病的重要事件。虽然支气管扩张剂和类固醇是治疗哮喘的两种主要药物,但许多成人和儿童仍然使用补充和替代(CAM)药物。本研究旨在从传统波斯医学(TPM)手稿的角度确定哮喘治疗中最流行的补救措施。方法对公元9 ~ 18世纪的主要传统波斯语教科书进行整理和分析。然后,收集了哮喘治疗中列出最多的植物。这些植物在最近的研究中被检索和比较。结果部分植物具有抗炎、抗氧化作用;其中一些已经在传统医学中进行了动物或人体研究。结论根据波斯悠久的医学史,收集到的治疗方法清单可为今后哮喘治疗研究选择植物提供参考。
{"title":"Remedies in asthma treatment: Introduce a new remedy from perspective of Persian medicine","authors":"M. Emtiazy, Laleh Oveidzadeh, M. Habibi, Z. Jafari, M. Kamalinejad","doi":"10.21767/AMJ.2017.3245","DOIUrl":"https://doi.org/10.21767/AMJ.2017.3245","url":null,"abstract":"Background Asthma is a chronic inflammatory disease of the airways. Mucus plug formation, oxidative stress, swelling of the airway walls, inflammatory process and vascular changes are important events in asthma pathogenesis. Aims Although bronchodilators and steroids are two main drugs in asthma treatment, many adults and children still use complementary and alternative (CAM) medicine. This study was conducted to determine the most popular remedies in asthma treatment from perspective of Traditional Persian medicine (TPM) manuscripts. Methods The main Traditional Persian textbooks from the 9th to 18th centuries AD were collected and analysed. Thereafter, the most listed plants in asthma treatment were gathered. The plants in this list were searched and compared in recent studies. Results Some of these plants have antiinflammatory and antioxidant effects; a few of them have undergone animal or human researches in conventional medicine. Conclusion According to long history of medicine in Persia the collected list of remedies could be helpful in selecting plants for future studies in asthma treatment.","PeriodicalId":46823,"journal":{"name":"Australasian Medical Journal","volume":"152 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68182573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Australasian Medical Journal
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