Background One of the most frequently encountered problems in outpatient and health screening centres is the elevation of Gamma Glutamyl Transpeptidase(y-GTP) levels. The measurement of y-GTP is a very sensitive indicator for screening for the presence of hepatobiliary disease. Especially, when alkaline phosphatase is elevated, it is a useful test to distinguish the presence of cholestasis. The diseases for which y-GTP can be elevated include diabetes, pancreatic disease, fatty liver, primary and metastatic liver cancer, cirrhosis, neuromuscular disease, myocardial infarction, hyperthyroidism, chronic obstructive pulmonary disease, chronic renal failure, prostate cancer, rheumatoid arthritis, Obesity, drugs, etc. Since y-GTP has a relatively high sensitivity and low specificity, it is preferable to perform it with other blood tests rather than performing it independently. The measurement of y-GTP is used as a test to diagnose alcohol abuse. Aims What is the meaning of y-GTP when it is raised independently or in relation to other liver function tests and how is it interpreted? In this article, we will examine the meaning of y-GTP elevation and its clinical application in primary care settings.
{"title":"Management for elevated serum Gamma Glutamyl Transpeptidase in primary care settings","authors":"S. Kim","doi":"10.21767/amj.2017.3293","DOIUrl":"https://doi.org/10.21767/amj.2017.3293","url":null,"abstract":"Background One of the most frequently encountered problems in outpatient and health screening centres is the elevation of Gamma Glutamyl Transpeptidase(y-GTP) levels. The measurement of y-GTP is a very sensitive indicator for screening for the presence of hepatobiliary disease. Especially, when alkaline phosphatase is elevated, it is a useful test to distinguish the presence of cholestasis. The diseases for which y-GTP can be elevated include diabetes, pancreatic disease, fatty liver, primary and metastatic liver cancer, cirrhosis, neuromuscular disease, myocardial infarction, hyperthyroidism, chronic obstructive pulmonary disease, chronic renal failure, prostate cancer, rheumatoid arthritis, Obesity, drugs, etc. Since y-GTP has a relatively high sensitivity and low specificity, it is preferable to perform it with other blood tests rather than performing it independently. The measurement of y-GTP is used as a test to diagnose alcohol abuse. Aims What is the meaning of y-GTP when it is raised independently or in relation to other liver function tests and how is it interpreted? In this article, we will examine the meaning of y-GTP elevation and its clinical application in primary care settings.","PeriodicalId":46823,"journal":{"name":"Australasian Medical Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68182862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahdieh Ghale Noee, M. Khorasanizadeh, T. Jamshidi, M. Nasiri
Background Patients with mental health illness have a variety of physical, mental, social, and spiritual needs and respecting their dignity and status is of the most important. Nurses and nursing students might have different attitudes with regard to observation of status and dignity of mental patients. Aims The present study is an attempt to comparatively survey nurses, nursing students, and patients’ attitudes about the observance of the patient’s dignity. Methods The study was carried out as a cross-sectional work on 300 participants in psychiatric wards of the selected hospitals of Kashan and Tehran cities in 2017. The participants were selected through purposeful sampling and data gathering was done using a demographics checklist and a researcherdesigned patient’s dignity observance questionnaire. Data analyses were done in SPSS (V.19) using descriptive and inferential tests (P-value=0.05). Results The three groups of participants were homogenous in terms of gender. There was a significant difference between psychiatric wards of the Kashan-based and Tehran-based hospitals in terms of attitudes about dignity of patients (P=0.04). In addition, the results confirmed a significant difference among the study groups with regard to their attitudes about the dignity of patients (p=0.000). Conclusion The nurses had better attitudes with regard to the observance of patient’s dignity in comparison with the patients and nursing students. There was also a difference between Kashan-based and Tehran-based hospitals as to the observance of patient’s dignity so that the attitudes in the former were better than that in the latter. It seems that holding moral training courses is essential.
{"title":"A comparative survey of the attitudes of nurses, nursing students, and patients as to the observance of the patients’ dignity in the psychiatric ward","authors":"Mahdieh Ghale Noee, M. Khorasanizadeh, T. Jamshidi, M. Nasiri","doi":"10.21767/amj.2017.3263","DOIUrl":"https://doi.org/10.21767/amj.2017.3263","url":null,"abstract":"Background Patients with mental health illness have a variety of physical, mental, social, and spiritual needs and respecting their dignity and status is of the most important. Nurses and nursing students might have different attitudes with regard to observation of status and dignity of mental patients. Aims The present study is an attempt to comparatively survey nurses, nursing students, and patients’ attitudes about the observance of the patient’s dignity. Methods The study was carried out as a cross-sectional work on 300 participants in psychiatric wards of the selected hospitals of Kashan and Tehran cities in 2017. The participants were selected through purposeful sampling and data gathering was done using a demographics checklist and a researcherdesigned patient’s dignity observance questionnaire. Data analyses were done in SPSS (V.19) using descriptive and inferential tests (P-value=0.05). Results The three groups of participants were homogenous in terms of gender. There was a significant difference between psychiatric wards of the Kashan-based and Tehran-based hospitals in terms of attitudes about dignity of patients (P=0.04). In addition, the results confirmed a significant difference among the study groups with regard to their attitudes about the dignity of patients (p=0.000). Conclusion The nurses had better attitudes with regard to the observance of patient’s dignity in comparison with the patients and nursing students. There was also a difference between Kashan-based and Tehran-based hospitals as to the observance of patient’s dignity so that the attitudes in the former were better than that in the latter. It seems that holding moral training courses is essential.","PeriodicalId":46823,"journal":{"name":"Australasian Medical Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68182907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Performing endoscopic retrograde cholangiopancreatography (ERCP) in patients with Zenker’s diverticulum can be technically difficult and is associated with the risk of oesophageal perforation with subsequent mediastinitis. Therefore, resistance is felt during oesophageal intubation with a duodenoscope, the operator should use a gastroscope to visualize any obstruction. If the existence of an oesophageal pouch is recognised, intubation can be safely performed using a guide-wire over tube technique. However, in specific situations (e.g., narrow oesophageal orifices in patients with low body mass index (BMI)) despite use of guide-wire technique, intubation can still be difficult. Therefore we present a modified guide-wire technique involving rotation of the duodenoscope under fluoroscopy, which opens the entrance to the oesophagus and enables safe intubation.
{"title":"Modification of intubation techniques during ERCP in patients with Zenker’s diverticulum","authors":"J. Andrzej","doi":"10.21767/AMJ.2017.3283","DOIUrl":"https://doi.org/10.21767/AMJ.2017.3283","url":null,"abstract":"Performing endoscopic retrograde cholangiopancreatography (ERCP) in patients with Zenker’s diverticulum can be technically difficult and is associated with the risk of oesophageal perforation with subsequent mediastinitis. Therefore, resistance is felt during oesophageal intubation with a duodenoscope, the operator should use a gastroscope to visualize any obstruction. If the existence of an oesophageal pouch is recognised, intubation can be safely performed using a guide-wire over tube technique. However, in specific situations (e.g., narrow oesophageal orifices in patients with low body mass index (BMI)) despite use of guide-wire technique, intubation can still be difficult. Therefore we present a modified guide-wire technique involving rotation of the duodenoscope under fluoroscopy, which opens the entrance to the oesophagus and enables safe intubation.","PeriodicalId":46823,"journal":{"name":"Australasian Medical Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68183133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Kahouei, A. Mohammadi, Ali Valinejadi, J. Zarei, Nasrollah Nasr Heidarabadi
Background Health related organizations have sought to design websites to provide various services, including access to relevant information by health care providers. Aims The purpose of this study was to investigate the understanding of health care staff members of the role of the health sector website of Semnan University of Medical Sciences in their health education. Methods This cross –sectional study was performed on 369 employees of health care institutions affiliated to Semnan University of Medical Sciences, Iran. An anonymous selfadministered questionnaire was developed. Results Mean score of the employees’ attitudes towards total characteristics of the health website were understanding of concepts of the health website was 3.65, for communications in the health website was 3.27 and for patientcentered of health website was 3.55. The results showed that there were significant relationships among total characteristics of the health website (P<0.001). Conclusion One can infer that the University's health department website is not proportionate to most of its domestic clients and could not provide the information needs of the healthcare staff. Therefore, practical and methodological considerations in the design of the website of the health department should be taken into consideration in order to provide user-oriented information on the website.
{"title":"The staffs’ understanding of the role of the health department website on health education in a university of medical sciences","authors":"M. Kahouei, A. Mohammadi, Ali Valinejadi, J. Zarei, Nasrollah Nasr Heidarabadi","doi":"10.21767/AMJ.2018.3254","DOIUrl":"https://doi.org/10.21767/AMJ.2018.3254","url":null,"abstract":"Background Health related organizations have sought to design websites to provide various services, including access to relevant information by health care providers. Aims The purpose of this study was to investigate the understanding of health care staff members of the role of the health sector website of Semnan University of Medical Sciences in their health education. Methods This cross –sectional study was performed on 369 employees of health care institutions affiliated to Semnan University of Medical Sciences, Iran. An anonymous selfadministered questionnaire was developed. Results Mean score of the employees’ attitudes towards total characteristics of the health website were understanding of concepts of the health website was 3.65, for communications in the health website was 3.27 and for patientcentered of health website was 3.55. The results showed that there were significant relationships among total characteristics of the health website (P<0.001). Conclusion One can infer that the University's health department website is not proportionate to most of its domestic clients and could not provide the information needs of the healthcare staff. Therefore, practical and methodological considerations in the design of the website of the health department should be taken into consideration in order to provide user-oriented information on the website.","PeriodicalId":46823,"journal":{"name":"Australasian Medical Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68183690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Baculovirus; late expression factors (Lef-7) have potential roles for protein expression in insect and mammalian cells; Efficient expression of recombinant proteins to facilitate the practical and structural investigation. Aims Lef-7 might play crucial roles in transcription and translation reactions of insect cell lines. Methods Materials and Methods: All required information regards Lef-7 was generated by exploring the internet search engine like as (PubMed, Wiley, ScienceDirect, CNKI, ACS, Google Scholar, Web of Science, SciFinder, and Baidu Scholar) and libraries. Results These properties issue crucial scope for DNA cloning and act as a vital vector for insect and mammalian cells. Left-7 could be the significant site in the development of the vaccine for a couple of chronic diseases. Further investigation needs to study on therapeutic vaccines with few immunologic advantages over proteins derived from mammalian sources, and animal sources. Lef-7 demonstrates the significant impact in the fields of DNA immunology research to insight into the mechanistic and utilitarian link between autoimmunity, infectious diseases, and cancer. Conclusion This review reveals Lef-7 gene function offers a workable strategy for the expression of whole viral protomers as the future prospect of Lef-7.
背景杆状病毒;晚表达因子(left -7)在昆虫和哺乳动物细胞中具有潜在的蛋白表达作用;高效表达重组蛋白，便于实际和结构研究。目的left -7可能在昆虫细胞系的转录和翻译反应中起重要作用。方法材料与方法:通过检索PubMed、Wiley、ScienceDirect、CNKI、ACS、b谷歌Scholar、Web of Science、SciFinder、百度Scholar等互联网搜索引擎和图书馆，生成关于Lef-7的所有所需信息。结果这些特性为DNA克隆提供了重要的空间，并可作为昆虫和哺乳动物细胞的重要载体。左-7可能是一些慢性疾病疫苗开发的重要位点。需要进行进一步的研究，以研究与来自哺乳动物和动物来源的蛋白质相比几乎没有免疫优势的治疗性疫苗。左7展示了DNA免疫学研究领域的重大影响，以深入了解自身免疫，传染病和癌症之间的机制和实用联系。结论研究结果表明，利用基因功能表达完整的病毒原体是一种可行的策略，是未来研究的前景。
{"title":"Future vital prospect of gene expression factors of lef-7 (baculovirus expression): Old body, young cherub","authors":"R. ferdous, Longshan Liu, Ruiping Yang","doi":"10.21767/AMJ.2018.3242","DOIUrl":"https://doi.org/10.21767/AMJ.2018.3242","url":null,"abstract":"Background Baculovirus; late expression factors (Lef-7) have potential roles for protein expression in insect and mammalian cells; Efficient expression of recombinant proteins to facilitate the practical and structural investigation. Aims Lef-7 might play crucial roles in transcription and translation reactions of insect cell lines. Methods Materials and Methods: All required information regards Lef-7 was generated by exploring the internet search engine like as (PubMed, Wiley, ScienceDirect, CNKI, ACS, Google Scholar, Web of Science, SciFinder, and Baidu Scholar) and libraries. Results These properties issue crucial scope for DNA cloning and act as a vital vector for insect and mammalian cells. Left-7 could be the significant site in the development of the vaccine for a couple of chronic diseases. Further investigation needs to study on therapeutic vaccines with few immunologic advantages over proteins derived from mammalian sources, and animal sources. Lef-7 demonstrates the significant impact in the fields of DNA immunology research to insight into the mechanistic and utilitarian link between autoimmunity, infectious diseases, and cancer. Conclusion This review reveals Lef-7 gene function offers a workable strategy for the expression of whole viral protomers as the future prospect of Lef-7.","PeriodicalId":46823,"journal":{"name":"Australasian Medical Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68183750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the 19 th century, barbiturates were first-line treatment as hypnotic and anticonvulsants, then gradually replaced by agents with a safer clinical profile. However, its ongoing use in Australian veterinary medicine and steadfast prescriptions in developing countries/our migrant population, still contributes to overdoses. We present a case of a middle-aged man with a lifethreatening phenobarbital overdose. Haemofiltration was trialled, causing a rapid fall in phenobarbital levels and a speedy recovery. Through a review of the literature, treatment options of barbiturate overdose presentations will be discussed. It is imperative clinicians are aware of barbiturate’s mechanism and its enhanced elimination through extracorporeal treatment.
{"title":"Successful haemofiltration therapy in severe phenobarbital overdose","authors":"E. Tan, M. Moser, G. Duke","doi":"10.21767/AMJ.2018.3307","DOIUrl":"https://doi.org/10.21767/AMJ.2018.3307","url":null,"abstract":"In the 19 th century, barbiturates were first-line treatment as hypnotic and anticonvulsants, then gradually replaced by agents with a safer clinical profile. However, its ongoing use in Australian veterinary medicine and steadfast prescriptions in developing countries/our migrant population, still contributes to overdoses. We present a case of a middle-aged man with a lifethreatening phenobarbital overdose. Haemofiltration was trialled, causing a rapid fall in phenobarbital levels and a speedy recovery. Through a review of the literature, treatment options of barbiturate overdose presentations will be discussed. It is imperative clinicians are aware of barbiturate’s mechanism and its enhanced elimination through extracorporeal treatment.","PeriodicalId":46823,"journal":{"name":"Australasian Medical Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68184198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A study of the prevalence and risk factors for cardiovascular disorders among patients registered with the primary health centres","authors":"M. Almansour","doi":"10.21767/amj.2018.3357","DOIUrl":"https://doi.org/10.21767/amj.2018.3357","url":null,"abstract":"","PeriodicalId":46823,"journal":{"name":"Australasian Medical Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68184359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Coexisting complete hydatidiform mole and live foetus","authors":"Ji Suk Han, Jong Soo Kim","doi":"10.21767/AMJ.2018.3379","DOIUrl":"https://doi.org/10.21767/AMJ.2018.3379","url":null,"abstract":"","PeriodicalId":46823,"journal":{"name":"Australasian Medical Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68184533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Smartphones have become pervasive in all aspects of modern life and the health care industry is not immune. Currently smartphone applications (apps) are used by 85–87 per cent of physicians. Surgical logbooks are a mandatory part of training and time consuming to maintain.
{"title":"A critical review of surgical logbook applications for the android and iOS platforms in the Australian setting","authors":"Navid Ahmadi, N. Sritharan, Elishan Aruliah","doi":"10.21767/AMJ.2018.3354","DOIUrl":"https://doi.org/10.21767/AMJ.2018.3354","url":null,"abstract":"Background Smartphones have become pervasive in all aspects of modern life and the health care industry is not immune. Currently smartphone applications (apps) are used by 85–87 per cent of physicians. Surgical logbooks are a mandatory part of training and time consuming to maintain.","PeriodicalId":46823,"journal":{"name":"Australasian Medical Journal","volume":"11 1","pages":"195-201"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68184838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. T. Phan, A. Nguyen, A. N. Nguyen, H. T. Nguyen, Toan Trong Ho, Suong Phuoc Pho, Binh T. Mai, Son Truong Nguyen
Background Lung cancer is the most common cause of cancer deaths in both sexes, while it is very difficult for screenings and early detection. Aims This study aims to clarify the role of systematic inflammation markers, including white blood cell (WBC), neutrophil (NEU), monocyte (MONO), platelet (PLT), neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR) and platelet to lymphocyte ratio (PLR) in prediction of lung cancer. Methods A case-control study was conducted on 1,315 primary lung cancer patients and 1,315 healthy adults with matched age and gender at Cho Ray hospital. NLR, MLR and PLR were calculated by using neutrophil, lymphocyte, monocyte and platelet count which were recalled from laboratory database. With 600 cases in the derivation set, the logistic regression with univariate analysis was used to identify the impacted marker, then developing the optimal prediction model for lung cancer by logistic regression with multivariate method. The diagnostic values of optimal model consisting of sensitivity (Sen), specificity (Spe), positive predictive value (PPV), negative predictive value (NPV) and the area under the ROC curve (AUC) value were extracted and verified on all data, in validation set. Results The median values of WBC, NEU, MONO, PLT, NLR, MLR and PLR in lung cancer were not significantly difference between histological subtypes and clinical stages (p>0.05), but higher than the values in control group (p<0.01). Multivariates analysis shows that NLR, MLR and WBC were three parameters that have the significant impact of the optimal prediction model (p<0.01). The AUC value, sensitivity and specificity of the optimal model for lung cancer detection were 0.881, 73.5 per cent (95 per cent CI:70.3–76.6) and 87.7 per cent (95 per centCI:85.2–89.9), respectively. Whereas, the PPV and NPV values of prediction model were 85.7 per cent (95 per cent CI:82.8–88.2) and 76.8 (95 per centCI:73.9–79.5), respectively. Among three biomarkers, the AUC values of NLR (0.853) and MLR (0.842) were higher than the value of WBC (0.752) (p<0.01). Conclusion The results of this study show that NLR with MLR and WBC in optimal prediction model are promising biomarkers for lung cancer screening that could be applied in clinical practice with the advantage of convenience and low cost.
{"title":"Neutrophil to lymphocyte with monocyte to lymphocyte ratio and white blood cell count in prediction of lung cancer","authors":"T. T. Phan, A. Nguyen, A. N. Nguyen, H. T. Nguyen, Toan Trong Ho, Suong Phuoc Pho, Binh T. Mai, Son Truong Nguyen","doi":"10.21767/amj.2018.3387","DOIUrl":"https://doi.org/10.21767/amj.2018.3387","url":null,"abstract":"Background Lung cancer is the most common cause of cancer deaths in both sexes, while it is very difficult for screenings and early detection. Aims This study aims to clarify the role of systematic inflammation markers, including white blood cell (WBC), neutrophil (NEU), monocyte (MONO), platelet (PLT), neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR) and platelet to lymphocyte ratio (PLR) in prediction of lung cancer. Methods A case-control study was conducted on 1,315 primary lung cancer patients and 1,315 healthy adults with matched age and gender at Cho Ray hospital. NLR, MLR and PLR were calculated by using neutrophil, lymphocyte, monocyte and platelet count which were recalled from laboratory database. With 600 cases in the derivation set, the logistic regression with univariate analysis was used to identify the impacted marker, then developing the optimal prediction model for lung cancer by logistic regression with multivariate method. The diagnostic values of optimal model consisting of sensitivity (Sen), specificity (Spe), positive predictive value (PPV), negative predictive value (NPV) and the area under the ROC curve (AUC) value were extracted and verified on all data, in validation set. Results The median values of WBC, NEU, MONO, PLT, NLR, MLR and PLR in lung cancer were not significantly difference between histological subtypes and clinical stages (p>0.05), but higher than the values in control group (p<0.01). Multivariates analysis shows that NLR, MLR and WBC were three parameters that have the significant impact of the optimal prediction model (p<0.01). The AUC value, sensitivity and specificity of the optimal model for lung cancer detection were 0.881, 73.5 per cent (95 per cent CI:70.3–76.6) and 87.7 per cent (95 per centCI:85.2–89.9), respectively. Whereas, the PPV and NPV values of prediction model were 85.7 per cent (95 per cent CI:82.8–88.2) and 76.8 (95 per centCI:73.9–79.5), respectively. Among three biomarkers, the AUC values of NLR (0.853) and MLR (0.842) were higher than the value of WBC (0.752) (p<0.01). Conclusion The results of this study show that NLR with MLR and WBC in optimal prediction model are promising biomarkers for lung cancer screening that could be applied in clinical practice with the advantage of convenience and low cost.","PeriodicalId":46823,"journal":{"name":"Australasian Medical Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68184940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：