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Prediction of complications in diabetes mellitus using machine learning models with transplanted topic model features 利用移植主题模型特征的机器学习模型预测糖尿病并发症
4区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2023-10-06 DOI: 10.1007/s13534-023-00322-7
Benedict Choonghyun Han, Jimin Kim, Jinwook Choi
Abstract Purpose : This study aims to predict the progression of Diabetes Mellitus (DM) from the clinical notes through machine learning based on latent Dirichlet allocation (LDA) topic modeling. Particularly, 174,427 clinical notes of DM patients were collected from the electronic medical record (EMR) system of the Seoul National University Hospital outpatient clinic. Method : We developed a model to predict the development of DM complications. Topics developed by the topic model were exploited as the key feature of our machine-learning model. The proposed model generalized a correlation between topic structures and complications. Results : The model provided acceptable predictive performance for all four types of complications (diabetic retinopathy, diabetic nephropathy, nonalcoholic fatty liver disease, and cerebrovascular accident). Upon employing extreme gradient boosting (XGBoost), we obtained the F1 scores of the predictions for each complication type as 0.844, 0.921, 0.831, and 0.762. Conclusion : This study shows that a machine learning project based on topic modeling can effectively predict the progress of a disease. Furthermore, a unique way of topic model transplanting, which matches the dimension of the topic structures of the two data sets, is presented.
摘要目的:本研究旨在通过基于潜在狄利克雷分配(latent Dirichlet allocation, LDA)主题建模的机器学习,从临床记录中预测糖尿病(DM)的进展。特别是,从首尔大学医院门诊电子病历(EMR)系统中收集了174427份糖尿病患者的临床记录。方法:建立糖尿病并发症预测模型。由主题模型开发的主题被用作我们的机器学习模型的关键特征。提出的模型概括了主题结构与复杂性之间的关系。结果:该模型对所有四种类型的并发症(糖尿病视网膜病变、糖尿病肾病、非酒精性脂肪性肝病和脑血管意外)提供了可接受的预测性能。采用极限梯度增强(XGBoost)后,各并发症类型的预测F1得分分别为0.844、0.921、0.831和0.762。结论:本研究表明,基于主题建模的机器学习项目可以有效地预测疾病的进展。在此基础上,提出了一种独特的主题模型移植方法,使两个数据集的主题结构维度相匹配。
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引用次数: 0
Automated blood glucose regulation for nonlinear model of type-1 diabetic patient under uncertainties: GWOCS type-2 fuzzy approach 不确定条件下1型糖尿病非线性模型的自动血糖调节:GWOCS 2型模糊方法
4区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2023-10-01 DOI: 10.1007/s13534-023-00318-3
Mohanad Elhoushy, Belal A. Zalam, Amged Sayed, Essam Nabil
Abstract Regulating blood glucose level (BGL) for type-1 diabetic patient (T1DP) accurately is very important issue, an uncontrolled BGL outside the standard safe range between 70 and 180 mg/dl results in dire consequences for health and can significantly increase the chance of death. So the purpose of this study is to design an optimized controller that infuses appropriate amounts of exogenous insulin into the blood stream of T1DP proportional to the amount of obtained glucose from food. The nonlinear extended Bergman minimal model is used to present glucose-insulin physiological system, an interval type-2 fuzzy logic controller (IT2FLC) is utilized to infuse the proper amount of exogenous insulin. Superiority of IT2FLC in minimizing the effect of uncertainties in the system depends primarily on the best choice of footprint of uncertainty (FOU) of IT2FLC. So a comparison includes four different optimization methods for tuning FOU including hybrid grey wolf optimizer-cuckoo search (GWOCS) and fuzzy logic controller (FLC) method is constructed to select the best controller approach. The effectiveness of the proposed controller was evaluated under six different scenarios of T1DP using Matlab/Simulink platform. A 24-h scenario close to real for 100 virtual T1DPs subjected to parametric uncertainty, uncertain meal disturbance and random initial condition showed that IT2FLC accurately regulate BGL for all T1DPs within the standard safe range. The results indicated that IT2FLC using GWOCS can prevent side effect of treatment with blood-sugar-lowering medication. Also stability analysis for the system indicated that the system operates within the stability region of nonlinear system.
准确调节1型糖尿病患者的血糖水平(BGL)是一个非常重要的问题,血糖控制在70 ~ 180 mg/dl的标准安全范围之外会对健康造成严重后果,并会显著增加死亡的机会。因此,本研究的目的是设计一个优化的控制器,将适量的外源性胰岛素注入T1DP的血流中,与从食物中获得的葡萄糖量成比例。采用非线性扩展Bergman最小模型来描述葡萄糖-胰岛素生理系统,采用区间2型模糊控制器(IT2FLC)注入适量外源性胰岛素。IT2FLC在最小化系统不确定性影响方面的优势主要取决于IT2FLC的不确定性足迹(FOU)的最佳选择。为此,对四种不同的优化方法进行了比较,包括灰狼优化-布谷鸟搜索(GWOCS)和模糊逻辑控制器(FLC)混合优化方法,以选择最优的控制器方法。利用Matlab/Simulink平台对该控制器在6种不同的T1DP场景下的有效性进行了评估。在参数不确定性、不确定膳食扰动和随机初始条件下,对100名虚拟T1DPs进行了24小时接近真实的模拟,结果表明,IT2FLC在标准安全范围内准确调节了所有T1DPs的BGL。结果表明,使用GWOCS治疗IT2FLC可预防降糖药物治疗的副作用。对系统的稳定性分析表明,系统运行在非线性系统的稳定区域内。
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引用次数: 0
Robotic-assisted unicompartmental knee arthroplasty: historical perspectives and current innovations. 机器人辅助单室膝关节置换术:历史观点和当前创新。
IF 3.2 4区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2023-09-28 eCollection Date: 2023-11-01 DOI: 10.1007/s13534-023-00323-6
Sung Eun Kim, Hyuk-Soo Han

Robotic assisted unicompartmental knee arthroplasty (RAUKA) has emerged as a successful approach for optimizing implant positioning accuracy, minimizing soft tissue injury, and improving patient-reported outcomes. The application of RAUKA is expected to increase because of its advantages over conventional unicompartmental knee arthroplasty. This review article provides an overview of RAUKA, encompassing the historical development of the procedure, the features of the robotic arm and navigation systems, and the characteristics of contemporary RAUKA. The article also includes a comparison between conventional unicompartmental arthroplasty and RAUKA, as well as a discussion of current challenges and future advancements in the field of RAUKA.

机器人辅助单室膝关节置换术(RAUKA)已成为优化植入物定位精度、最大限度地减少软组织损伤和改善患者报告结果的一种成功方法。RAUKA的应用有望增加,因为它比传统的单室膝关节置换术有优势。这篇综述文章概述了RAUKA,包括该程序的历史发展、机械臂和导航系统的特点以及当代RAUKA的特点。文章还包括传统单室关节成形术和RAUKA之间的比较,以及对RAUKA领域当前挑战和未来进展的讨论。
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引用次数: 0
Funding of research & innovation in the field of medical technologies and biomedical engineering over the different European framework programmes 研究经费;在不同的欧洲框架方案的医疗技术和生物医学工程领域的创新
4区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2023-09-27 DOI: 10.1007/s13534-023-00320-9
B. W. Rainer
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引用次数: 0
A review of emergent intelligent systems for the detection of Parkinson's disease. 帕金森病检测的紧急智能系统综述。
IF 3.2 4区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2023-09-20 eCollection Date: 2023-11-01 DOI: 10.1007/s13534-023-00319-2
Samiappan Dhanalakshmi, Ramesh Sai Maanasaa, Ramesh Sai Maalikaa, Ramalingam Senthil

Parkinson's disease (PD) is a neurodegenerative disorder affecting people worldwide. The PD symptoms are divided into motor and non-motor symptoms. Detection of PD is very crucial and essential. Such challenges can be overcome by applying artificial intelligence to diagnose PD. Many studies have also proposed the implementation of computer-aided diagnosis for the detection of PD. This systematic review comprehensively analyzed all appropriate algorithms for detecting and assessing PD based on the literature from 2012 to 2023 which are conducted as per PRISMA model. This review focused on motor symptoms, namely handwriting dynamics, voice impairments and gait, multimodal features, and brain observation using single photon emission computed tomography, magnetic resonance and electroencephalogram signals. The significant challenges are critically analyzed, and appropriate recommendations are provided. The critical discussion of this review article can be helpful in today's PD community in such a way that it allows clinicians to provide proper treatment and timely medication.

帕金森病(PD)是一种影响全世界的神经退行性疾病。帕金森病症状分为运动症状和非运动症状。PD的检测是至关重要的。将人工智能应用于PD诊断可以克服这些挑战。许多研究也提出了应用计算机辅助诊断来检测PD。本系统综述基于2012年至2023年根据PRISMA模型进行的文献,全面分析了检测和评估PD的所有适当算法。这篇综述的重点是运动症状,即笔迹动力学、语音障碍和步态、多模式特征,以及使用单光子发射计算机断层扫描、磁共振和脑电图信号进行的大脑观察。对重大挑战进行了批判性分析,并提出了适当的建议。这篇综述文章的批判性讨论可以帮助当今的帕金森病社区,使临床医生能够提供适当的治疗和及时的药物治疗。
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引用次数: 0
Advancement of a RGBW-LED pen for diaphanoscopic illumination with adjustable color and intensity with tests on ex-vivo porcine eyes in terms of retinal risk and correlated color temperature 一种可调颜色和强度的RGBW-LED透光笔的研制,并在离体猪眼上进行视网膜风险和相关色温的测试
4区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2023-09-15 DOI: 10.1007/s13534-023-00317-4
Nicole Fehler, David Schneider, Martin Hessling
Abstract Diaphanoscopic illumination has the disadvantage that the intraocular spectrum is red-shifted due to transmission properties of the eyewall. This red-shift should be counteracted as well as the retinal risk should be reduced with adjusting the spectral distribution of the illumination light. Likewise, the illumination spectrum has to be adapted to the eye color of the patient. With the further development of a red, green, blue and white light-emitting diode (RGBW-LED) diaphanoscopy pen, the intensities of each color can be varied. The functionality of the LED pen is tested on ex-vivo porcine eyes. By measuring the transmission of the sclera and choroidea, the photochemical and thermal retinal hazard and the maximum exposure time are determined according to the standard DIN EN ISO 15004-2:2007. With this RGBW-LED pen the intraocular space can be illuminated clearly of up to 1.5 h without potential retinal damage according to DIN EN ISO 15004:2-2007. By adjusting the illumination spectrum the red-shift can be compensated and retinal risk can be reduced. By varying the LED intensities, the correlated color temperature in the eye can also be varied from cold white to warm white appearance as comfortable to the ophthalmologist. Additionally, a simple adjustment of the illumination to the eye color of the patient is possible. Using this RGBW-LED pen, the ophthalmologist can set the desired intraocular color appearance, which he prefers for special applications. He could also adjust the illumination to the eye color as this would reduce retinal hazard.
摘要:透光镜照明的缺点是由于眼壁的透射特性导致眼内光谱发生红移。这种红移应该被抵消,以及视网膜的风险应该减少调整光谱分布的照明光。同样,照明光谱也必须适应病人眼睛的颜色。随着红、绿、蓝、白四色发光二极管(RGBW-LED)透光笔的进一步发展,每种颜色的强度都可以变化。LED笔的功能在离体猪眼睛上进行了测试。通过测量巩膜和脉络膜的透射率,根据DIN EN ISO 15004-2:2007标准确定视网膜的光化学和热危害及最大暴露时间。根据DIN EN ISO 15004:2-2007,使用RGBW-LED笔可以在1.5小时内清晰地照亮眼内空间,而不会对视网膜造成潜在损害。通过调节照明光谱可以补偿红移,降低视网膜风险。通过改变LED的强度,眼睛的相关色温也可以从冷白到暖白,这对眼科医生来说是舒适的。此外,对患者眼睛颜色的照明进行简单的调整也是可能的。使用这种RGBW-LED笔,眼科医生可以设置所需的眼内颜色外观,这是他喜欢的特殊应用。他还可以根据眼睛的颜色调整照明,这样可以减少视网膜的危害。
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引用次数: 0
Sneaky emotions: impact of data partitions in affective computing experiments with brain-computer interfacing 鬼鬼祟祟的情绪:脑机接口情感计算实验中数据分区的影响
4区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2023-09-11 DOI: 10.1007/s13534-023-00316-5
Yoelvis Moreno-Alcayde, V. Javier Traver, Luis A. Leiva
Abstract Brain-Computer Interfacing (BCI) has shown promise in Machine Learning (ML) for emotion recognition. Unfortunately, how data are partitioned in training/test splits is often overlooked, which makes it difficult to attribute research findings to actual modeling improvements or to partitioning issues. We introduce the “data transfer rate” construct (i.e., how much data of the test samples are seen during training) and use it to examine data partitioning effects under several conditions. As a use case, we consider emotion recognition in videos using electroencephalogram (EEG) signals. Three data splits are considered, each representing a relevant BCI task: subject-independent (affective decoding), video-independent (affective annotation), and time-based (feature extraction). Model performance may change significantly (ranging e.g. from 50% to 90%) depending on how data is partitioned, in classification accuracy. This was evidenced in all experimental conditions tested. Our results show that (1) for affective decoding, it is hard to achieve performance above the baseline case (random classification) unless some data of the test subjects are considered in the training partition; (2) for affective annotation, having data from the same subject in training and test partitions, even though they correspond to different videos, also increases performance; and (3) later signal segments are generally more discriminative, but it is the number of segments (data points) what matters the most. Our findings not only have implications in how brain data are managed, but also in how experimental conditions and results are reported.
脑机接口(BCI)在机器学习(ML)的情感识别中显示出前景。不幸的是,如何在训练/测试分割中划分数据经常被忽视,这使得很难将研究结果归因于实际的建模改进或划分问题。我们引入了“数据传输速率”结构(即,在训练期间看到的测试样本的数据量),并使用它来检查几种条件下的数据分区效果。作为一个用例,我们考虑使用脑电图(EEG)信号来识别视频中的情绪。我们考虑了三种数据分割,每一种都代表一个相关的BCI任务:独立于主题(情感解码)、独立于视频(情感注释)和基于时间(特征提取)。模型性能可能会发生显著变化(例如从50%到90%不等),这取决于数据的划分方式和分类精度。这在所有测试的实验条件下都得到了证明。我们的研究结果表明:(1)对于情感解码,除非在训练分区中考虑一些测试对象的数据,否则很难达到高于基线情况(随机分类)的性能;(2)对于情感注释,在训练和测试分区中使用来自同一主题的数据,即使它们对应不同的视频,也可以提高性能;(3)后期的信号段通常更具判别性,但最重要的是段(数据点)的数量。我们的发现不仅对如何管理大脑数据有影响,而且对如何报告实验条件和结果也有影响。
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引用次数: 0
Undersampling and cumulative class re-decision methods to improve detection of agitation in people with dementia 欠采样和累积类再决策方法提高痴呆患者躁动的检测
4区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2023-08-28 DOI: 10.1007/s13534-023-00313-8
Zhidong Meng, Andrea Iaboni, Bing Ye, Kristine Newman, Alex Mihailidis, Zhihong Deng, Shehroz S. Khan
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引用次数: 0
Towards automatic EEG cyclic alternating pattern analysis: a systematic review. 自动脑电循环交替模式分析:系统综述。
IF 4.6 4区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2023-07-19 eCollection Date: 2023-08-01 DOI: 10.1007/s13534-023-00303-w
Fábio Mendonça, Sheikh Shanawaz Mostafa, Fernando Morgado-Dias, Antonio G Ravelo-García, Ivana Rosenzweig

This study conducted a systematic review to determine the feasibility of automatic Cyclic Alternating Pattern (CAP) analysis. Specifically, this review followed the 2020 Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines to address the formulated research question: is automatic CAP analysis viable for clinical application? From the identified 1,280 articles, the review included 35 studies that proposed various methods for examining CAP, including the classification of A phase, their subtypes, or the CAP cycles. Three main trends were observed over time regarding A phase classification, starting with mathematical models or features classified with a tuned threshold, followed by using conventional machine learning models and, recently, deep learning models. Regarding the CAP cycle detection, it was observed that most studies employed a finite state machine to implement the CAP scoring rules, which depended on an initial A phase classifier, stressing the importance of developing suitable A phase detection models. The assessment of A-phase subtypes has proven challenging due to various approaches used in the state-of-the-art for their detection, ranging from multiclass models to creating a model for each subtype. The review provided a positive answer to the main research question, concluding that automatic CAP analysis can be reliably performed. The main recommended research agenda involves validating the proposed methodologies on larger datasets, including more subjects with sleep-related disorders, and providing the source code for independent confirmation.

本研究进行了系统综述,以确定自动循环交替模式(CAP)分析的可行性。具体而言,本综述遵循了2020年系统综述和荟萃分析首选报告项目(PRISMA)指南,以解决制定的研究问题:自动CAP分析是否适用于临床应用?在已确定的1280篇文章中,该综述包括35项研究,这些研究提出了检查CAP的各种方法,包括A期、其亚型或CAP周期的分类。随着时间的推移,在A阶段分类方面观察到了三个主要趋势,从数学模型或用调谐阈值分类的特征开始,然后使用传统的机器学习模型,最近使用深度学习模型。关于CAP循环检测,据观察,大多数研究都使用有限状态机来实现CAP评分规则,该规则依赖于初始a阶段分类器,强调了开发合适的a阶段检测模型的重要性。事实证明,对A期亚型的评估具有挑战性,因为在最先进的检测方法中使用了各种方法,从多类模型到为每个亚型创建模型。该综述为主要研究问题提供了积极的答案,得出的结论是可以可靠地进行自动CAP分析。主要建议的研究议程包括在更大的数据集上验证所提出的方法,包括更多患有睡眠相关障碍的受试者,并提供独立确认的源代码。
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引用次数: 0
Comparative study of the SleepImage ring device and polysomnography for diagnosing obstructive sleep apnea. 睡眠成像环和多导睡眠图诊断阻塞性睡眠呼吸暂停的比较研究。
IF 3.2 4区 医学 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2023-07-17 eCollection Date: 2023-08-01 DOI: 10.1007/s13534-023-00304-9
Mi Lu, Lisa Brenzinger, Lisa Rosenblum, Matthew Salanitro, Ingo Fietze, Martin Glos, Giuseppe Fico, Thomas Penzel

Purpose We aim to evaluate the diagnostic performance of the SleepImage Ring device in identifying obstructive sleep apnea (OSA) across different severity in comparison to standard polysomnography (PSG). Methods Thirty-nine patients (mean age, 56.8 ± 15.0 years; 29 [74.3%] males) were measured with the SleepImage Ring and PSG study simultaneously in order to evaluate the diagnostic performance of the SleepImage device for diagnosing OSA. Variables such as sensitivity, specificity, positive and negative likelihood ratio, positive and negative predictive value, and accuracy were calculated with PSG-AHI thresholds of 5, 15, and 30 events/h. Receiver operating characteristic curves were also built according to the above PSG-AHI thresholds. In addition, we analyzed the correlation and agreement between the apnea-hypopnea index (AHI) obtained from the two measurement devices. Results There was a strong correlation (r = 0.89, P < 0.001 and high agreement in AHI between the SleepImage Ring and standard PSG. Also, the SleepImage Ring showed reliable diagnostic capability, with areas under the receiver operating characteristic curve of 1.00 (95% CI, 0.91, 1.00), 0.90 (95% CI, 0.77, 0.97), and 0.98 (95% CI, 0.88, 1.000) for corresponding PSG-AHI of 5, 15 and 30 events/h, respectively. Conclusion The SleepImage Ring could be a clinically reliable and cheaper alternative to the gold standard PSG when aiming to diagnose OSA in adults.

Supplementary information: The online version contains supplementary material available at 10.1007/s13534-023-00304-9.

目的:与标准多导睡眠图(PSG)相比,我们旨在评估SleepImage Ring设备在识别不同严重程度的阻塞性睡眠呼吸暂停(OSA)方面的诊断性能。方法39例患者(平均年龄56.8岁) ± 15.0年;29名[74.3%]男性)同时用SleepImage Ring和PSG研究进行测量,以评估SleepImage设备诊断OSA的诊断性能。使用PSG-AHI阈值5、15和30次事件/h来计算敏感性、特异性、阳性和阴性似然比、阳性和阳性预测值以及准确性等变量。还根据上述PSG-AHI阈值建立了接收器工作特性曲线。此外,我们还分析了从两种测量设备获得的呼吸暂停低通气指数(AHI)之间的相关性和一致性。结果二者之间存在很强的相关性(r = 0.89,P 结论SleepImage Ring可作为诊断成人OSA的金标准PSG的临床可靠且廉价的替代品。补充信息:在线版本包含补充材料,可访问10.1007/s13534-023-00304-9。
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引用次数: 0
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Biomedical Engineering Letters
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