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Caffeine, lactic acid, or nothing: What effect does expectation have on men's performance and perceived exertion during an upper body muscular endurance task? 咖啡因、乳酸,或者什么都没有:在上半身肌肉耐力任务中,期望对男性的表现和感知力有什么影响?
IF 2 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-11-01
Dara Campelo, Alexander J Koch, Marco Machado

Objective: We tested the impact of subjects' belief in an ingested substance's ergogenic or ergolytic properties on muscular endurance performance and perceived exertion.

Methods: Trained men (n = 15, age = 41 ± 4 y; body mass = 82.1 ± 15.8 kg; height = 173 ± 8 cm; experience = 7.4 ± 2.3 y) completed one set to failure at 80% repetition maximum of the bench press under three conditions. In all conditions, subjects ingested capsules of an identical, inert substance (300 mg cellulose), but, in a randomized order, subjects were told that they were either ingesting caffeine (Placebo), lactic acid (Nocebo), or cellulose (Control) and received information on the respective alleged ergogenic/ergolytic/neutral effects of each. Repetitions completed and rating of perceived exertion (RPE) were recorded. The data were analyzed among conditions using a Friedman test with post hoc analyses accomplished through Durbin-Conover tests. Spearman correlations were used to compare repetitions performed and RPE between Nocebo and Placebo conditions. Statistical significance was set at P ≤ 0.05.

Results: Subjects lifted more (P < 0.001) repetitions in the Placebo condition (14.1 ± 3.0) versus Control (10.3 ± 2.9) or Nocebo (7.5 ± 2.6), while Control and Nocebo performances were similar (P = 0.192). Lower RPE was noted in Placebo versus Control (P = 0.003) and Nocebo (P < 0.001) and lower in Control versus Nocebo (P = 0.025). Subjects who performed more repetitions with Placebo tended to perform fewer repetitions under the Nocebo condition (Spearman's Rho =-0.578).

Conclusion: This study believes that the ergogenic or ergolytic properties of a substance can measurably impact upper-body muscular endurance performance and RPE in trained men.

目的:我们测试了受试者对摄入物质的麦角或溶麦角特性的信念对肌肉耐力表现和感知用力的影响。方法:经过训练的男性(n=15,年龄=41±4 y;体重=82.1±15.8 kg;身高=173±8 cm;经验=7.4±2.3 y)在三种条件下完成了一组失败,最大重复次数为80%。在所有条件下,受试者都摄入了相同惰性物质(300mg纤维素)的胶囊,但按照随机顺序,被试者被告知他们摄入了咖啡因(安慰剂)、乳酸(诺西博)或纤维素(对照),并收到了关于每种物质各自声称的麦角/麦角/中性作用的信息。记录完成的重复次数和感觉用力(RPE)评分。使用Friedman检验在不同条件下分析数据,并通过Durbin-Conover检验进行事后分析。Spearman相关性用于比较诺西博和安慰剂条件下的重复次数和RPE。统计学显著性设定为P≤0.05。结果:受试者在安慰剂条件下(14.1±3.0)比对照组(10.3±2.9)或诺西博(7.5±2.6)重复次数更多(P<0.001),而对照组和诺西博的表现相似(P=0.192)。安慰剂组的RPE低于对照组(P=0.003)和诺西博组(P<0.001),对照组低于诺西博组(P=0.025)。在诺西博条件下,安慰剂重复次数较多的受试者往往重复次数较少(Spearman Rho=-0.578)。结论:本研究认为一种物质的性质可以显著影响受过训练的男性的上半身肌肉耐力表现和RPE。
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引用次数: 0
Differential expression of cancer stem cell markers and pro-inflammatory cytokine IL-1β in the oral squamous cell carcinoma and oral submucosal fibrosis. 癌症干细胞标志物和促炎细胞因子IL-1β在口腔鳞状细胞癌和口腔黏膜下纤维化中的差异表达。
IF 2 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-11-01
Shriddha Awasthi, Sharique Ahmad, Rahul Gupta, Mohammed Shariq Iqbal, Ausaf Ahmad

Objectives: The poor prognosis of oral squamous cell carcinoma (OSCC) is vastly due to late diagnosis. The oral submucosal fibrosis (OSMF) is often unnoticed pathology linked with high risk of malignancy. Recently, we demonstrated that the clinicopathological alterations in OSMF and OSCC patients were correlated with cancer stem cell (CSCs) markers (CD133 and CD44). However, the parallel alterations of interleukin-1 beta (IL-1β) with CSCs expression are largely unexplored. Thus, we aimed to investigate the relationship between IL-1β alterations and CSC marker expression in both OSMF and OSCC situations.

Materials and methods: A total of 135 people have signed up for the study. There were sixty each in OSMF and OSCC groups, as well as 15 healthy controls. Levels of serum IL-1β were examined by ELISA. Immunohistochemistry (IHC) was used to examine the expression of CD133 and CD44. For evaluating differential CSCs expression, IHC scoring (0-4) was utilized.

Results: The IHC results showed maximum subjects in the OSMF and OSCC displaying CD44 and CD133 positivity, although the extent of expression in terms of IHC scoring found variable. CD133 and CD44-positive subjects showed increased levels of IL-1β in the OSMF and OSCC group. Nevertheless, the enhancement of IL-1β is more pronounced in the OSCC cases. Further, we observed a direct link of IL-1β levels with IHC scoring. Multivariate regression analysis demonstrated a significant role for CD44 and CD133 positivity in the increase of IL-1β levels.

Conclusion: We concluded that concurrent simultaneous changes in CSC biomarkers and IL-1β may help with early detection of OSMF and OSCC conditions.

目的:口腔鳞状细胞癌(OSCC)的预后不良在很大程度上是由于诊断较晚。口腔黏膜下纤维化(OSMF)通常是与恶性肿瘤高风险相关的未被注意的病理学。最近,我们证实OSMF和OSCC患者的临床病理改变与癌症干细胞(CSCs)标志物(CD133和CD44)相关。然而,白细胞介素-1β(IL-1β)与CSCs表达的平行变化在很大程度上尚未被探索。因此,我们旨在研究OSMF和OSCC情况下IL-1β改变与CSC标记物表达之间的关系。材料和方法:共有135人报名参加了这项研究。OSMF和OSCC组各60例,健康对照组15例。ELISA法检测血清IL-1β水平。免疫组织化学(IHC)检测CD133和CD44的表达。为了评估CSCs的差异表达,采用IHC评分(0-4)。结果:IHC结果显示,OSMF和OSCC中CD44和CD133阳性的受试者最多,尽管IHC评分的表达程度各不相同。CD133和CD44阳性受试者在OSMF和OSCC组中显示IL-1β水平升高。然而,IL-1β的增强在OSCC病例中更为明显。此外,我们观察到IL-1β水平与IHC评分直接相关。多元回归分析显示CD44和CD133阳性在IL-1β水平升高中起着重要作用。结论:我们得出结论,CSC生物标志物和IL-1β同时发生变化可能有助于早期检测OSMF和OSCC情况。
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引用次数: 0
Application of contrast-enhanced ultrasound to evaluate skeletal muscle perfusion in lower extremity arteriosclerotic obliterans of type 2 diabetes mellitus 应用超声造影评价2型糖尿病下肢动脉硬化闭塞症骨骼肌灌注
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-30 DOI: 10.53730/ijhs.v7n3.14501
Weili Lin, Penghui Wang, Fulai Cai, Runming Zhong
To evaluate the value of contrast-enhanced ultrasound in evaluating skeletal muscle perfusion in Type 2 diabetic patients with lower extremity arteriosclerosis occlusion. 80 patients with type 2 diabetes were prospectively studied and divided into two groups: 40 patients with lower extremity arteriosclerosis obliterans(observation group)and 40 diabetic volunteers with normal lower extremity arteries(control group).All subjects were subjected to the same contrast-enhanced ultrasound(CEUS) technique before and after exercise to observe the changes of skeletal muscle blood perfusion in the calf, and the time to peak(TTP)of skeletal muscle blood perfusion parameters in the two groups were compared. The time-intensity curve established by mathematical model showed that TTP in the observation group was significantly longer than TTP in the control group in the resting state and after exercise, with statistical significance(P<0.05). TTP had no significant correlation with age, hypertension and other factors(P>0.05). TTP was correlated with ankle-brachial index (ABI)(P<0.05). In conclusion, CEUS can objectively reflect the changes of skeletal muscle perfusion in patients with lower extremity arteriosclerosis obliteration before and after exercise, and it is a new diagnostic method and evaluation index to observe the changes of skeletal muscle perfusion in patients with type 2 diabetes.
目的探讨超声造影评价2型糖尿病合并下肢动脉硬化闭塞患者骨骼肌灌注的价值。前瞻性研究80例2型糖尿病患者,分为两组:40例下肢动脉硬化闭塞患者(观察组)和40例下肢动脉正常的糖尿病志愿者(对照组)。所有受试者在运动前后均采用相同的超声造影(CEUS)技术,观察小腿骨骼肌血流灌注的变化,比较两组骨骼肌血流灌注参数的峰值时间(TTP)。数学模型建立的时间-强度曲线显示,观察组在静息状态和运动后的TTP均明显长于对照组,差异有统计学意义(P<0.05)。TTP与年龄、高血压等因素无显著相关性(P>0.05)。TTP与踝肱指数(ankle-brachial index, ABI)相关(P<0.05)。综上所述,超声造影能客观反映下肢动脉硬化闭塞患者运动前后骨骼肌灌注的变化,观察2型糖尿病患者骨骼肌灌注的变化是一种新的诊断方法和评价指标。
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引用次数: 0
Influence of Stakeholder Dynamics on Performance of Free Maternal Healthcare Project in Kenya, a Case of Homabay County 利益相关者动态对肯尼亚免费孕产妇保健项目绩效的影响——以霍马拜县为例
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-24 DOI: 10.47941/ijhs.1481
Alice Christine Awuor, Jared Deya
Purpose: The study examined the influence of sponsor, client, project team and regulatory dynamics, on project performance of free maternity in Homabay County, Kenya.The research focused on factors other than healthcare costs to ensure adequate infrastructure and health personnel in order to offer quality care for the growing number of clients. Besides it added to the existing body of knowledge pertaining to the delivery of free maternity services thereby reducing and eliminating maternal and perinatal deaths. It was conducted in eight sub-county hospitals in the county. Methodology: A total of 167 respondents were selected to participate in the study. The data were entered and analyzed by SPSS version 16. The coefficient of determination showed that sponsor dynamics had a major contribution to the project performance. Findings: There was a significant positive relationship between sponsor dynamics and project performance of free maternal healthcare in Homabay County, Kenya. Unique contribution to theory, practice and policy: The study therefore recommended that Donors and other implementing agencies ought to make their procedures flexible in order to accommodate input from other project stakeholders.
目的:研究主办者、客户、项目团队和监管动态对肯尼亚霍马拜县免费分娩项目绩效的影响。研究的重点是保健费用以外的因素,以确保有足够的基础设施和保健人员,以便为越来越多的客户提供高质量的护理。此外,它补充了有关提供免费产妇服务的现有知识体系,从而减少和消除产妇和围产期死亡。在该县8个县二级医院开展。 方法:共选取167名受访者参与本研究。采用SPSS 16进行数据录入和分析。决定系数表明,资助者动态对项目绩效有重大贡献。 结果:肯尼亚霍马贝县孕产妇免费保健项目的赞助动态与项目绩效之间存在显著的正相关关系。 对理论、实践和政策的独特贡献:因此,该研究建议捐助者和其他执行机构应使其程序灵活,以便适应其他项目利益攸关方的投入。
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引用次数: 0
Frequency of alterations in qSOFA, SIRS, MEWS and NEWS scores during the emergency department stay in infectious patients 感染性患者在急诊科住院期间qSOFA、SIRS、MEWS和NEWS评分改变的频率
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-21 DOI: 10.53730/ijhs.v7ns1.14606
Rami Mahmoud Ibrahim, Mahmood Mohammed Ghanaim
Background: Sepsis has received ongoing attention over the past 10 years as common illness that accounts for Ten percent of ICU admissions & is linked to ten–twenty percent in-hospital mortality rate. For those investigated patients with suspected infections, clinical rules based on vital signs are typically calculated as soon as researched person enters emergency department. Clinical rule scores that are normal or abnormal provide information on the diagnosis & outlook. Due to the cyclical nature of vital signs, clinical rule scores may fluctuate. Aim: In this research, we looked at how frequently results of four commonly applied clinical rules changed during which cases with assumed infections were being treated in emergency department. Summary: Future studies, in our opinion, must concentrate on viability, use, & predictive value of repeated or continuous vital sign monitoring across acute care chain. respiratory rates have to get special attention as it has been consistently demonstrated to be significant predictor of clinical worsening, despite being evaluated infrequently & insufficiently.
背景:脓毒症作为一种常见病在过去的10年里受到了持续的关注,占ICU入院人数的10%。与10%到20%的住院死亡率有关对于疑似感染的被调查患者,通常在被调查人员进入急诊科时就计算出基于生命体征的临床规则。正常或异常的临床规则评分提供了诊断信息。前景。由于生命体征的周期性,临床规则评分可能会波动。目的:在这项研究中,我们观察了四种常用临床规则的结果在假定感染的病例在急诊室治疗期间的变化频率。总结:在我们看来,未来的研究必须集中在可行性,使用,&急性护理链中重复或连续生命体征监测的预测价值。呼吸频率必须得到特别的关注,因为它一直被证明是临床恶化的重要预测指标,尽管很少被评估。不够。
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引用次数: 0
Point of care ultrasound as initial diagnostic tool in acute dyspnea patients in the emergency department of a tertiary care center 护理点超声作为三级护理中心急诊科急性呼吸困难患者的初始诊断工具
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-21 DOI: 10.53730/ijhs.v7ns1.14605
Rami Mahmoud Ibrahim, Mahmood Mohammed Ghanaim
Background: 1 of frequent symptoms that patients report to the emergency department has been dyspnea. In addition to clinical evaluation, a wide range of differentials frequently needs laboratory & radiographic tests, adding needless delay. Point-of-care in emergency departments, ultrasonography has been widely used tool as it can quickly & safely diagnose studied cases of dyspnea. Our research aimed to find out if point-of-care ultrasound has been used in our settings as primary diagnostic tool for patients with acute dyspnea. Summary: Dyspnea is 1 of the common problems that patients present to the ER. Wide variety of differentials typically calls for laboratory and radiographic investigations, causing final diagnosis to be delayed needlessly. In emergency rooms, point-of-care ultrasonography is popular tool since it can quickly & safely diagnose these dyspnea patients while also saving time. The goal of the study had been to determine whether point-of-care ultrasound had been useful in examining cases with acute dyspnea in settings as the main diagnostic tool.
背景:患者向急诊科报告的常见症状之一是呼吸困难。除了临床评估外,广泛的差异往往需要实验室检查。射线检查,增加了不必要的延误。在急诊科的护理点,超声检查已被广泛使用的工具,因为它可以快速&安全诊断所研究的呼吸困难病例。我们的研究目的是找出点护理超声是否已在我们的设置中用作急性呼吸困难患者的主要诊断工具。摘要:呼吸困难是患者向急诊室就诊的常见问题之一。各种各样的差异通常需要实验室和放射检查,导致最终诊断不必要地延迟。在急诊室,即时超声检查是一种很受欢迎的工具,因为它可以快速检查。安全诊断这些呼吸困难患者的同时也节省了时间。该研究的目的是确定作为主要诊断工具的即时超声在检查急性呼吸困难病例中是否有用。
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引用次数: 0
Peripheral venous lactate levels substitute arterial lactate levels in the emergency department 急诊用外周静脉乳酸水平代替动脉乳酸水平
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-21 DOI: 10.53730/ijhs.v7ns1.14604
Rami Mahmoud Ibrahim, Mahmood Mohammed Ghanaim
Background: The level of arterial lactate has been a significant indicator of studied case's prognosis. Blood gas analysis's low concordance rate between AL & peripheral venous lactate makes PVL ineffective as AL alternative. Nevertheless, PVL can be a different way to forecast studied case's prognosis, & risk of arterial puncture problems with AL can be decreased if AL range may be predicted from PVL. This can be a quick & secure test technique. Aim: To assess if VL levels may replace certain ranges of AL levels, we reviewed association among VL & AL levels in same critically sick studied cases at time of initial evaluation. Venous blood gas analysis (which lowers risk of problems related to arterial puncture required for AL measurement) can be safer & quicker test for critically ill studied cases if VL values may be utilized as substitute for AL levels. Summary: The level of arterial lactate has been significant indicator of studied case's prognosis. Blood gas analysis's low concordance rate between AL & peripheral venous lactate makes PVL ineffective as AL alternative.
背景:动脉乳酸水平已成为研究病例预后的重要指标。AL &血气分析符合率低;外周静脉乳酸使PVL作为AL替代品无效。然而,PVL可以作为预测研究病例预后的另一种方法,&如果可以通过PVL预测AL范围,可以降低AL动脉穿刺问题的风险。这可以是一个快速的&安全的测试技术。目的:为了评估VL水平是否可以取代某些范围的AL水平,我们回顾了VL与amp;初步评估时同一危重病例的AL水平。静脉血气分析(降低了动脉穿刺测量所需的问题风险)可能更安全。如果VL值可以代替AL值,则可以更快地检测危重病例。摘要:动脉乳酸水平已成为判断患者预后的重要指标。AL &血气分析符合率低;外周静脉乳酸使PVL作为AL替代品无效。
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引用次数: 0
Assessing the Degree of Determinant Impact on the Management Outcomes of Drug Sensitive Pulmonary Tuberculosis in Sierra Leone-A Case Study of Rural Bo District. 对塞拉利昂药物敏感性肺结核管理结果的决定性影响程度评估——以Bo农村地区为例
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-20 DOI: 10.47941/ijhs.1477
Tommy Allieu, Precious M. Tommy BSc
Purpose: Treatment outcomes of tuberculosis are strongly influenced by the level of socioeconomic status of a population. Predisposing factors of tuberculosis such as undernutrition, diabetes, and AIDS are hinged on the socioeconomic status of a population. Alcohol, smoking and illicit drug use disorders can predispose to TB especially in hyperendemic setting. Sierra Leone still grapples with socio-economic challenges including all the factors that predispose people to the disease and as well precipitates TB transmission. Methodology: The study was a retrospective cohort study to assess the degree of impact on the determinants of drug sensitive pulmonary tuberculosis treatment outcomes in patients managed in catchment areas in the rural Bo district of Southern Sierra Leone. Data were collected from 2176 participants with even ID numbers enrolled from January 2018 to January 2022 out of the population of 533,900. Sample was calculated at a 99% confidence level and 3% margin of error. Findings: A Chi2 test was performed between age: α= <15 yrs β= ≥15yrs and exit which showed a statistically significant relationship between the two, χ² (4) = 188.32, p = <0.001, Cramér’s V = 0.29 with the calculated p-value of <0.001 that is lower than the defined significance level of 5%. There was also a statistically significant relationship between source of income and exit, χ² (12) = 94.57, p = <0.001, There was a statistically significant relationship between food security and exit, χ² (4) = 15.32, p = 0.004, Cramér’s V = 0.08. The calculated p-value of 0.004 is lower than the defined significance level of 5%. Unique contribution to theory, practice and policy: Shows that favorable treatment outcomes are a combination of use of chemotherapy, psychosocial care, social, economic and economic moderation strategies especially in the global South where the majority of the patients live in poverty.
目的:结核病的治疗结果受人群的社会经济地位水平的强烈影响。结核病的易感因素,如营养不良、糖尿病和艾滋病,取决于人口的社会经济地位。酒精、吸烟和非法药物使用障碍可使人易患结核病,特别是在高流行环境中。塞拉利昂仍在努力应对社会经济挑战,包括使人们易患这种疾病并促使结核病传播的所有因素。方法:该研究是一项回顾性队列研究,旨在评估在塞拉利昂南部Bo农村集水区管理的患者对药物敏感肺结核治疗结果的决定因素的影响程度。数据收集自2018年1月至2022年1月在533,900人口中登记的2176名具有偶数身份证号码的参与者。样本以99%的置信水平和3%的误差范围计算。 结果:年龄α= 15岁β=≥15岁与退出年龄之间进行Chi2检验,χ 2 (4) = 188.32, p = <0.001, cram s V = 0.29,计算p值为<0.001,低于5%的定义显著性水平。收入来源与出口之间的关系也具有统计学意义,χ²(12)= 94.57,p = <0.001;粮食安全与出口之间的关系具有统计学意义,χ²(4)= 15.32,p = 0.004, cram’s V = 0.08。计算的p值为0.004,低于5%的定义显著性水平。 对理论、实践和政策的独特贡献:表明有利的治疗结果是化疗、社会心理护理、社会、经济和经济调节策略的结合,特别是在大多数患者生活在贫困中的全球南方国家。
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引用次数: 0
Histomorphological study of mucormycosis in COVID-19 patients COVID-19患者毛霉病的组织形态学研究
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-17 DOI: 10.53730/ijhs.v7ns1.14596
Siddiq Mukkamil Ahmed, M. N. Divyarani, A. N. Roopa, S. M. Sowmya, Raj Mohammed, Rehan Baig, Samiyah Syeed Ahmed
Background: Mucormycosis is a rapidly progressive angioinvasive fungal infection which has a high rate of mortality and morbidity. Mucormycosis most commonly invades the nose and paranasal sinuses presenting as rhinosinusitis. We noted an upsurge in the number of patients affected with Mucormycosis during Covid-19 infection era. Aim: Our study aims to illustrate the histopathology of Mucormycosis in post-Covid-19 patients and also to study the fungal morphology by utilizing special stains. Materials and Methods: We prospectively analysed the histopathological findings of fungal elements in 260 different histopathological samples of mucormycosis in post-covid-19 patients. The clinical and histopathological findings were noted and tabulated. Statistical Analysis Used: The data collected was tabulated and coded in Microsoft excel. All the data of demographic and clinical characteristics were analysed by descriptive statistics and percentage. Tables and graphs were added wherever applicable. Results: Out of 260 cases analysed, most of the patients presented with periorbital swelling followed by headache and nasal block. Histopathologically, most of the cases showed chronic inflammatory reaction with wide areas of necrosis and granuloma formation. The fungal elements have been appreciated and sensitivity of different stains to appreciate the fungal structures have been compared.
背景:毛霉病是一种进展迅速的血管侵袭性真菌感染,具有很高的死亡率和发病率。毛霉菌病最常侵袭鼻和副鼻窦,表现为鼻窦炎。我们注意到,在Covid-19感染时期,毛霉菌病患者人数激增。目的:研究新型冠状病毒感染后毛霉菌病患者的组织病理学,并利用特殊染色剂研究其真菌形态。材料与方法:前瞻性分析260例新型冠状病毒感染后毛霉病患者不同组织病理学标本中真菌元素的组织病理学结果。记录临床和组织病理学结果并制成表格。统计分析方法:收集的数据在Microsoft excel中进行制表和编码。所有资料的人口学和临床特征采用描述性统计和百分比分析。在适当的地方添加了表格和图表。结果:260例患者以眶周肿胀为主,其次为头痛和鼻阻塞。组织病理学上,大多数病例表现为慢性炎症反应,伴有大面积坏死和肉芽肿形成。对真菌成分进行了鉴定,并比较了不同染色剂对真菌结构的敏感性。
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引用次数: 0
Investigation of variations of pyrazinamide resistance and gene Xpert-based molecular typing in tuberculosis patients 结核病患者吡嗪酰胺耐药性变异及基因专家分子分型研究
Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-12 DOI: 10.53730/ijhs.v7ns1.14599
Riffat Naseem, Muhammad Israr, Shahzaib Khan, Muhammad Aarab, Muhammad Yousuf, Hafiz Zia Ullah Abid
The morbidity, death, and medication resistance caused by Mycobacterium tuberculosis are global health concern. The Gene Xpert is employed to diagnose TB early and find pyrazinamide (PYR) resistance at the same time. Our goal was to examine the clinical TB situation at Faisalabad's tertiary care institutions and to use Gene Xpert to determine the prevalence of TB and the drug resistance pattern. In this research, 135 samples from probable TB patients were included, and Gene Xpert identified 127 samples as positive. The gender, age group (50 years), sample type (sputum and pleural), and number of M. tuberculosis by ct value (cycle threshold) were all taken into consideration when categorizing the samples. The findings of the current investigation revealed a significant positive frequency of TB in male patients and in the 31-50 years age ranges. Patients with TB had a high prevalence of M. tuberculosis in the low and medium categories. 16 of the 127 TB patients who tested positive for the disease had pyrazinamide resistance. Our study concluded that Gene Xpert is a useful method for quickly diagnosing and treating TB since it can quickly detect M. tuberculosis and pyrazinamide resistance.
结核分枝杆菌引起的发病率、死亡率和耐药性是全球卫生关注的问题。Xpert基因用于结核病的早期诊断,同时发现pyrazinamide (PYR)耐药性。我们的目标是检查费萨拉巴德三级保健机构的临床结核病情况,并使用Gene Xpert来确定结核病的流行情况和耐药模式。在这项研究中,纳入了来自可能的结核病患者的135个样本,Gene Xpert鉴定出127个样本呈阳性。在对样本进行分类时,考虑了性别、年龄组(50岁)、样本类型(痰液和胸膜)以及结核分枝杆菌ct值(周期阈值)数目。目前调查的结果显示,男性患者和31-50岁年龄组的结核病阳性频率很高。结核病患者在中低类别中结核分枝杆菌的患病率较高。127名结核病检测呈阳性的患者中有16人对吡嗪酰胺具有耐药性。本研究认为,基因Xpert可以快速检测结核分枝杆菌和吡嗪酰胺耐药性,是一种有效的快速诊断和治疗结核病的方法。
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引用次数: 0
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International Journal of Health Sciences-IJHS
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