Pub Date : 2023-10-21DOI: 10.53730/ijhs.v7ns1.14605
Rami Mahmoud Ibrahim, Mahmood Mohammed Ghanaim
Background: 1 of frequent symptoms that patients report to the emergency department has been dyspnea. In addition to clinical evaluation, a wide range of differentials frequently needs laboratory & radiographic tests, adding needless delay. Point-of-care in emergency departments, ultrasonography has been widely used tool as it can quickly & safely diagnose studied cases of dyspnea. Our research aimed to find out if point-of-care ultrasound has been used in our settings as primary diagnostic tool for patients with acute dyspnea. Summary: Dyspnea is 1 of the common problems that patients present to the ER. Wide variety of differentials typically calls for laboratory and radiographic investigations, causing final diagnosis to be delayed needlessly. In emergency rooms, point-of-care ultrasonography is popular tool since it can quickly & safely diagnose these dyspnea patients while also saving time. The goal of the study had been to determine whether point-of-care ultrasound had been useful in examining cases with acute dyspnea in settings as the main diagnostic tool.
{"title":"Point of care ultrasound as initial diagnostic tool in acute dyspnea patients in the emergency department of a tertiary care center","authors":"Rami Mahmoud Ibrahim, Mahmood Mohammed Ghanaim","doi":"10.53730/ijhs.v7ns1.14605","DOIUrl":"https://doi.org/10.53730/ijhs.v7ns1.14605","url":null,"abstract":"Background: 1 of frequent symptoms that patients report to the emergency department has been dyspnea. In addition to clinical evaluation, a wide range of differentials frequently needs laboratory & radiographic tests, adding needless delay. Point-of-care in emergency departments, ultrasonography has been widely used tool as it can quickly & safely diagnose studied cases of dyspnea. Our research aimed to find out if point-of-care ultrasound has been used in our settings as primary diagnostic tool for patients with acute dyspnea. Summary: Dyspnea is 1 of the common problems that patients present to the ER. Wide variety of differentials typically calls for laboratory and radiographic investigations, causing final diagnosis to be delayed needlessly. In emergency rooms, point-of-care ultrasonography is popular tool since it can quickly & safely diagnose these dyspnea patients while also saving time. The goal of the study had been to determine whether point-of-care ultrasound had been useful in examining cases with acute dyspnea in settings as the main diagnostic tool.","PeriodicalId":47093,"journal":{"name":"International Journal of Health Sciences-IJHS","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135513190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-21DOI: 10.53730/ijhs.v7ns1.14604
Rami Mahmoud Ibrahim, Mahmood Mohammed Ghanaim
Background: The level of arterial lactate has been a significant indicator of studied case's prognosis. Blood gas analysis's low concordance rate between AL & peripheral venous lactate makes PVL ineffective as AL alternative. Nevertheless, PVL can be a different way to forecast studied case's prognosis, & risk of arterial puncture problems with AL can be decreased if AL range may be predicted from PVL. This can be a quick & secure test technique. Aim: To assess if VL levels may replace certain ranges of AL levels, we reviewed association among VL & AL levels in same critically sick studied cases at time of initial evaluation. Venous blood gas analysis (which lowers risk of problems related to arterial puncture required for AL measurement) can be safer & quicker test for critically ill studied cases if VL values may be utilized as substitute for AL levels. Summary: The level of arterial lactate has been significant indicator of studied case's prognosis. Blood gas analysis's low concordance rate between AL & peripheral venous lactate makes PVL ineffective as AL alternative.
{"title":"Peripheral venous lactate levels substitute arterial lactate levels in the emergency department","authors":"Rami Mahmoud Ibrahim, Mahmood Mohammed Ghanaim","doi":"10.53730/ijhs.v7ns1.14604","DOIUrl":"https://doi.org/10.53730/ijhs.v7ns1.14604","url":null,"abstract":"Background: The level of arterial lactate has been a significant indicator of studied case's prognosis. Blood gas analysis's low concordance rate between AL & peripheral venous lactate makes PVL ineffective as AL alternative. Nevertheless, PVL can be a different way to forecast studied case's prognosis, & risk of arterial puncture problems with AL can be decreased if AL range may be predicted from PVL. This can be a quick & secure test technique. Aim: To assess if VL levels may replace certain ranges of AL levels, we reviewed association among VL & AL levels in same critically sick studied cases at time of initial evaluation. Venous blood gas analysis (which lowers risk of problems related to arterial puncture required for AL measurement) can be safer & quicker test for critically ill studied cases if VL values may be utilized as substitute for AL levels. Summary: The level of arterial lactate has been significant indicator of studied case's prognosis. Blood gas analysis's low concordance rate between AL & peripheral venous lactate makes PVL ineffective as AL alternative.","PeriodicalId":47093,"journal":{"name":"International Journal of Health Sciences-IJHS","volume":"20 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135513169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: Treatment outcomes of tuberculosis are strongly influenced by the level of socioeconomic status of a population. Predisposing factors of tuberculosis such as undernutrition, diabetes, and AIDS are hinged on the socioeconomic status of a population.
Alcohol, smoking and illicit drug use disorders can predispose to TB especially in hyperendemic setting. Sierra Leone still grapples with socio-economic challenges including all the factors that predispose people to the disease and as well precipitates TB transmission.
Methodology: The study was a retrospective cohort study to assess the degree of impact on the determinants of drug sensitive pulmonary tuberculosis treatment outcomes in patients managed in catchment areas in the rural Bo district of Southern Sierra Leone. Data were collected from 2176 participants with even ID numbers enrolled from January 2018 to January 2022 out of the population of 533,900. Sample was calculated at a 99% confidence level and 3% margin of error.
Findings: A Chi2 test was performed between age: α= <15 yrs β= ≥15yrs and exit which showed a statistically significant relationship between the two, χ² (4) = 188.32, p = <0.001, Cramér’s V = 0.29 with the calculated p-value of <0.001 that is lower than the defined significance level of 5%. There was also a statistically significant relationship between source of income and exit, χ² (12) = 94.57, p = <0.001, There was a statistically significant relationship between food security and exit, χ² (4) = 15.32, p = 0.004, Cramér’s V = 0.08. The calculated p-value of 0.004 is lower than the defined significance level of 5%.
Unique contribution to theory, practice and policy: Shows that favorable treatment outcomes are a combination of use of chemotherapy, psychosocial care, social, economic and economic moderation strategies especially in the global South where the majority of the patients live in poverty.
目的:结核病的治疗结果受人群的社会经济地位水平的强烈影响。结核病的易感因素，如营养不良、糖尿病和艾滋病，取决于人口的社会经济地位。酒精、吸烟和非法药物使用障碍可使人易患结核病，特别是在高流行环境中。塞拉利昂仍在努力应对社会经济挑战，包括使人们易患这种疾病并促使结核病传播的所有因素。方法:该研究是一项回顾性队列研究，旨在评估在塞拉利昂南部Bo农村集水区管理的患者对药物敏感肺结核治疗结果的决定因素的影响程度。数据收集自2018年1月至2022年1月在533,900人口中登记的2176名具有偶数身份证号码的参与者。样本以99%的置信水平和3%的误差范围计算。
结果:年龄α= 15岁β=≥15岁与退出年龄之间进行Chi2检验，χ 2 (4) = 188.32, p = <0.001, cram s V = 0.29，计算p值为<0.001，低于5%的定义显著性水平。收入来源与出口之间的关系也具有统计学意义，χ²(12)= 94.57,p = <0.001;粮食安全与出口之间的关系具有统计学意义，χ²(4)= 15.32,p = 0.004, cram’s V = 0.08。计算的p值为0.004，低于5%的定义显著性水平。
对理论、实践和政策的独特贡献:表明有利的治疗结果是化疗、社会心理护理、社会、经济和经济调节策略的结合，特别是在大多数患者生活在贫困中的全球南方国家。
{"title":"Assessing the Degree of Determinant Impact on the Management Outcomes of Drug Sensitive Pulmonary Tuberculosis in Sierra Leone-A Case Study of Rural Bo District.","authors":"Tommy Allieu, Precious M. Tommy BSc","doi":"10.47941/ijhs.1477","DOIUrl":"https://doi.org/10.47941/ijhs.1477","url":null,"abstract":"Purpose: Treatment outcomes of tuberculosis are strongly influenced by the level of socioeconomic status of a population. Predisposing factors of tuberculosis such as undernutrition, diabetes, and AIDS are hinged on the socioeconomic status of a population.
 Alcohol, smoking and illicit drug use disorders can predispose to TB especially in hyperendemic setting. Sierra Leone still grapples with socio-economic challenges including all the factors that predispose people to the disease and as well precipitates TB transmission.
 Methodology: The study was a retrospective cohort study to assess the degree of impact on the determinants of drug sensitive pulmonary tuberculosis treatment outcomes in patients managed in catchment areas in the rural Bo district of Southern Sierra Leone. Data were collected from 2176 participants with even ID numbers enrolled from January 2018 to January 2022 out of the population of 533,900. Sample was calculated at a 99% confidence level and 3% margin of error.
 Findings: A Chi2 test was performed between age: α= <15 yrs β= ≥15yrs and exit which showed a statistically significant relationship between the two, χ² (4) = 188.32, p = <0.001, Cramér’s V = 0.29 with the calculated p-value of <0.001 that is lower than the defined significance level of 5%. There was also a statistically significant relationship between source of income and exit, χ² (12) = 94.57, p = <0.001, There was a statistically significant relationship between food security and exit, χ² (4) = 15.32, p = 0.004, Cramér’s V = 0.08. The calculated p-value of 0.004 is lower than the defined significance level of 5%.
 Unique contribution to theory, practice and policy: Shows that favorable treatment outcomes are a combination of use of chemotherapy, psychosocial care, social, economic and economic moderation strategies especially in the global South where the majority of the patients live in poverty.","PeriodicalId":47093,"journal":{"name":"International Journal of Health Sciences-IJHS","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135616273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-17DOI: 10.53730/ijhs.v7ns1.14596
Siddiq Mukkamil Ahmed, M. N. Divyarani, A. N. Roopa, S. M. Sowmya, Raj Mohammed, Rehan Baig, Samiyah Syeed Ahmed
Background: Mucormycosis is a rapidly progressive angioinvasive fungal infection which has a high rate of mortality and morbidity. Mucormycosis most commonly invades the nose and paranasal sinuses presenting as rhinosinusitis. We noted an upsurge in the number of patients affected with Mucormycosis during Covid-19 infection era. Aim: Our study aims to illustrate the histopathology of Mucormycosis in post-Covid-19 patients and also to study the fungal morphology by utilizing special stains. Materials and Methods: We prospectively analysed the histopathological findings of fungal elements in 260 different histopathological samples of mucormycosis in post-covid-19 patients. The clinical and histopathological findings were noted and tabulated. Statistical Analysis Used: The data collected was tabulated and coded in Microsoft excel. All the data of demographic and clinical characteristics were analysed by descriptive statistics and percentage. Tables and graphs were added wherever applicable. Results: Out of 260 cases analysed, most of the patients presented with periorbital swelling followed by headache and nasal block. Histopathologically, most of the cases showed chronic inflammatory reaction with wide areas of necrosis and granuloma formation. The fungal elements have been appreciated and sensitivity of different stains to appreciate the fungal structures have been compared.
{"title":"Histomorphological study of mucormycosis in COVID-19 patients","authors":"Siddiq Mukkamil Ahmed, M. N. Divyarani, A. N. Roopa, S. M. Sowmya, Raj Mohammed, Rehan Baig, Samiyah Syeed Ahmed","doi":"10.53730/ijhs.v7ns1.14596","DOIUrl":"https://doi.org/10.53730/ijhs.v7ns1.14596","url":null,"abstract":"Background: Mucormycosis is a rapidly progressive angioinvasive fungal infection which has a high rate of mortality and morbidity. Mucormycosis most commonly invades the nose and paranasal sinuses presenting as rhinosinusitis. We noted an upsurge in the number of patients affected with Mucormycosis during Covid-19 infection era. Aim: Our study aims to illustrate the histopathology of Mucormycosis in post-Covid-19 patients and also to study the fungal morphology by utilizing special stains. Materials and Methods: We prospectively analysed the histopathological findings of fungal elements in 260 different histopathological samples of mucormycosis in post-covid-19 patients. The clinical and histopathological findings were noted and tabulated. Statistical Analysis Used: The data collected was tabulated and coded in Microsoft excel. All the data of demographic and clinical characteristics were analysed by descriptive statistics and percentage. Tables and graphs were added wherever applicable. Results: Out of 260 cases analysed, most of the patients presented with periorbital swelling followed by headache and nasal block. Histopathologically, most of the cases showed chronic inflammatory reaction with wide areas of necrosis and granuloma formation. The fungal elements have been appreciated and sensitivity of different stains to appreciate the fungal structures have been compared.","PeriodicalId":47093,"journal":{"name":"International Journal of Health Sciences-IJHS","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135992896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-12DOI: 10.53730/ijhs.v7ns1.14599
Riffat Naseem, Muhammad Israr, Shahzaib Khan, Muhammad Aarab, Muhammad Yousuf, Hafiz Zia Ullah Abid
The morbidity, death, and medication resistance caused by Mycobacterium tuberculosis are global health concern. The Gene Xpert is employed to diagnose TB early and find pyrazinamide (PYR) resistance at the same time. Our goal was to examine the clinical TB situation at Faisalabad's tertiary care institutions and to use Gene Xpert to determine the prevalence of TB and the drug resistance pattern. In this research, 135 samples from probable TB patients were included, and Gene Xpert identified 127 samples as positive. The gender, age group (50 years), sample type (sputum and pleural), and number of M. tuberculosis by ct value (cycle threshold) were all taken into consideration when categorizing the samples. The findings of the current investigation revealed a significant positive frequency of TB in male patients and in the 31-50 years age ranges. Patients with TB had a high prevalence of M. tuberculosis in the low and medium categories. 16 of the 127 TB patients who tested positive for the disease had pyrazinamide resistance. Our study concluded that Gene Xpert is a useful method for quickly diagnosing and treating TB since it can quickly detect M. tuberculosis and pyrazinamide resistance.
{"title":"Investigation of variations of pyrazinamide resistance and gene Xpert-based molecular typing in tuberculosis patients","authors":"Riffat Naseem, Muhammad Israr, Shahzaib Khan, Muhammad Aarab, Muhammad Yousuf, Hafiz Zia Ullah Abid","doi":"10.53730/ijhs.v7ns1.14599","DOIUrl":"https://doi.org/10.53730/ijhs.v7ns1.14599","url":null,"abstract":"The morbidity, death, and medication resistance caused by Mycobacterium tuberculosis are global health concern. The Gene Xpert is employed to diagnose TB early and find pyrazinamide (PYR) resistance at the same time. Our goal was to examine the clinical TB situation at Faisalabad's tertiary care institutions and to use Gene Xpert to determine the prevalence of TB and the drug resistance pattern. In this research, 135 samples from probable TB patients were included, and Gene Xpert identified 127 samples as positive. The gender, age group (50 years), sample type (sputum and pleural), and number of M. tuberculosis by ct value (cycle threshold) were all taken into consideration when categorizing the samples. The findings of the current investigation revealed a significant positive frequency of TB in male patients and in the 31-50 years age ranges. Patients with TB had a high prevalence of M. tuberculosis in the low and medium categories. 16 of the 127 TB patients who tested positive for the disease had pyrazinamide resistance. Our study concluded that Gene Xpert is a useful method for quickly diagnosing and treating TB since it can quickly detect M. tuberculosis and pyrazinamide resistance.","PeriodicalId":47093,"journal":{"name":"International Journal of Health Sciences-IJHS","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136012863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to investigate the clinical efficacy of transarterial chemoembolization (TACE) in conjunction with terminal branches portal vein embolization (TBPVE) in the context of planned hepatectomy. A cohort of five patients afflicted by primary hepatocellular carcinoma who were deemed unsuitable candidates for primary surgical resection was gathered from August 2019 to December 2021. Following the application of TACE in combination with TBPVE as a therapeutic intervention, we observed postoperative general reactions, alterations in tumor biomarkers, hyperplasia of future liver remnant (FLR), and subsequent surgical resection. All patients successfully underwent the combined TACE and TBPVE procedure, achieving a technical success rate of 100%. One week after TACE, alpha-fetoprotein (AFP) levels decreased from 38.52±49.21 to 25.27±37.94 μg/L, and Protein Induced by Vitamin K Absence or Antagonist (PIVKA) levels decreased from 1689.30±1663.83 to 219.03±228.10 μg/L. Two weeks post-TBPVE, FLR exhibited an increment from 350.80±41.17 to 476.00±57.91 mL. The ratio of FLR to standard liver volume (SLV) increased from 30.94%±3.63% to 42.03%±5.62%. The combined application of TACE and TBPVE not only effectively manages tumor progression but also augments the FLR, thereby affording patients with a limited future liver remnant an opportunity for surgical resection of hepatocellular carcinoma.
{"title":"Clinical application of transarterial chemoembolization combined with terminal branches portal vein embolization in planned hepatectomy","authors":"Guoqing Zhu, Wenhao Hu, Wei Xiang, Junwei Ni, Liyang Dong","doi":"10.53730/ijhs.v7ns1.14563","DOIUrl":"https://doi.org/10.53730/ijhs.v7ns1.14563","url":null,"abstract":"This study aimed to investigate the clinical efficacy of transarterial chemoembolization (TACE) in conjunction with terminal branches portal vein embolization (TBPVE) in the context of planned hepatectomy. A cohort of five patients afflicted by primary hepatocellular carcinoma who were deemed unsuitable candidates for primary surgical resection was gathered from August 2019 to December 2021. Following the application of TACE in combination with TBPVE as a therapeutic intervention, we observed postoperative general reactions, alterations in tumor biomarkers, hyperplasia of future liver remnant (FLR), and subsequent surgical resection. All patients successfully underwent the combined TACE and TBPVE procedure, achieving a technical success rate of 100%. One week after TACE, alpha-fetoprotein (AFP) levels decreased from 38.52±49.21 to 25.27±37.94 μg/L, and Protein Induced by Vitamin K Absence or Antagonist (PIVKA) levels decreased from 1689.30±1663.83 to 219.03±228.10 μg/L. Two weeks post-TBPVE, FLR exhibited an increment from 350.80±41.17 to 476.00±57.91 mL. The ratio of FLR to standard liver volume (SLV) increased from 30.94%±3.63% to 42.03%±5.62%. The combined application of TACE and TBPVE not only effectively manages tumor progression but also augments the FLR, thereby affording patients with a limited future liver remnant an opportunity for surgical resection of hepatocellular carcinoma.","PeriodicalId":47093,"journal":{"name":"International Journal of Health Sciences-IJHS","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135045843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to investigate the clinical efficacy of transarterial chemoembolization (TACE) in conjunction with terminal branches portal vein embolization (TBPVE) in the context of planned hepatectomy. A cohort of five patients afflicted by primary hepatocellular carcinoma who were deemed unsuitable candidates for primary surgical resection was gathered from August 2019 to December 2021. Following the application of TACE in combination with TBPVE as a therapeutic intervention, we observed postoperative general reactions, alterations in tumor biomarkers, hyperplasia of future liver remnant (FLR), and subsequent surgical resection. All patients successfully underwent the combined TACE and TBPVE procedure, achieving a technical success rate of 100%. One week after TACE, alpha-fetoprotein (AFP) levels decreased from 38.52±49.21 to 25.27±37.94 μg/L, and Protein Induced by Vitamin K Absence or Antagonist (PIVKA) levels decreased from 1689.30±1663.83 to 219.03±228.10 μg/L. Two weeks post-TBPVE, FLR exhibited an increment from 350.80±41.17 to 476.00±57.91 mL. The ratio of FLR to standard liver volume (SLV) increased from 30.94%±3.63% to 42.03%±5.62%. The combined application of TACE and TBPVE not only effectively manages tumor progression but also augments the FLR, thereby affording patients with a limited future liver remnant an opportunity for surgical resection of hepatocellular carcinoma.
{"title":"Clinical application of transarterial chemoembolization combined with terminal branches portal vein embolization in planned hepatectomy","authors":"Guoqing Zhu, Wenhao Hu, Wei Xiang, Junwei Ni, Liyang Dong","doi":"10.53730/ijhs.v7n3.14563","DOIUrl":"https://doi.org/10.53730/ijhs.v7n3.14563","url":null,"abstract":"This study aimed to investigate the clinical efficacy of transarterial chemoembolization (TACE) in conjunction with terminal branches portal vein embolization (TBPVE) in the context of planned hepatectomy. A cohort of five patients afflicted by primary hepatocellular carcinoma who were deemed unsuitable candidates for primary surgical resection was gathered from August 2019 to December 2021. Following the application of TACE in combination with TBPVE as a therapeutic intervention, we observed postoperative general reactions, alterations in tumor biomarkers, hyperplasia of future liver remnant (FLR), and subsequent surgical resection. All patients successfully underwent the combined TACE and TBPVE procedure, achieving a technical success rate of 100%. One week after TACE, alpha-fetoprotein (AFP) levels decreased from 38.52±49.21 to 25.27±37.94 μg/L, and Protein Induced by Vitamin K Absence or Antagonist (PIVKA) levels decreased from 1689.30±1663.83 to 219.03±228.10 μg/L. Two weeks post-TBPVE, FLR exhibited an increment from 350.80±41.17 to 476.00±57.91 mL. The ratio of FLR to standard liver volume (SLV) increased from 30.94%±3.63% to 42.03%±5.62%. The combined application of TACE and TBPVE not only effectively manages tumor progression but also augments the FLR, thereby affording patients with a limited future liver remnant an opportunity for surgical resection of hepatocellular carcinoma.","PeriodicalId":47093,"journal":{"name":"International Journal of Health Sciences-IJHS","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135149536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-08DOI: 10.53730/ijhs.v7n3.14490
Shengzhang Lin, Zhaohong Wang, Xufan Cai
It has been shown that ginsenosides can inhibit proliferation, migration, and invasion of pancreatic cancer (PC) cells, and promote apoptosis of PC cells. However, the potential mechanisms of ginseng in treating PC metastasis (PCM) have not been fully elucidated. In this study, we employed an integrated bioinformatics approach of network pharmacology analysis. By selecting common targets of diseases and drugs, a drug-component-target-disease network was constructed to analyze the biological functions and signaling pathways involved in the targets. A total of 6 PC samples were includedd, which were divided into primary PC group (PANC-1, n=3) and metastatic PC group. A total of 9263 differentially expressed genes (DEGs) and 14 PC target genes were identified. According to the network pharmacology analysis, we found that ginsenoside Rg3 was associated with the treatment of PCM and identified 6 potential targets. Among them, CD44, EGFR, KRAS, and PRNP were the main DEGs related to the treatment of PC by ginsenoside Rg3. These genes were mainly enriched in the Proteoglycans in Cancer pathway, and KRAS, EGFR, and CD44 were upregulated in the pathway, which may be affected by the ginsenoside Rg3. This provides a new direction for further research on the mechanisms of ginseng in PCM.
{"title":"Mechanisms of ginseng in pancreatic cancer metastasis","authors":"Shengzhang Lin, Zhaohong Wang, Xufan Cai","doi":"10.53730/ijhs.v7n3.14490","DOIUrl":"https://doi.org/10.53730/ijhs.v7n3.14490","url":null,"abstract":"It has been shown that ginsenosides can inhibit proliferation, migration, and invasion of pancreatic cancer (PC) cells, and promote apoptosis of PC cells. However, the potential mechanisms of ginseng in treating PC metastasis (PCM) have not been fully elucidated. In this study, we employed an integrated bioinformatics approach of network pharmacology analysis. By selecting common targets of diseases and drugs, a drug-component-target-disease network was constructed to analyze the biological functions and signaling pathways involved in the targets. A total of 6 PC samples were includedd, which were divided into primary PC group (PANC-1, n=3) and metastatic PC group. A total of 9263 differentially expressed genes (DEGs) and 14 PC target genes were identified. According to the network pharmacology analysis, we found that ginsenoside Rg3 was associated with the treatment of PCM and identified 6 potential targets. Among them, CD44, EGFR, KRAS, and PRNP were the main DEGs related to the treatment of PC by ginsenoside Rg3. These genes were mainly enriched in the Proteoglycans in Cancer pathway, and KRAS, EGFR, and CD44 were upregulated in the pathway, which may be affected by the ginsenoside Rg3. This provides a new direction for further research on the mechanisms of ginseng in PCM.","PeriodicalId":47093,"journal":{"name":"International Journal of Health Sciences-IJHS","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135250979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-08DOI: 10.53730/ijhs.v7ns1.14490
Zhaohong Wang, Xufan Cai, Shengzhang Lin
It has been shown that ginsenosides can inhibit proliferation, migration, and invasion of pancreatic cancer (PC) cells, and promote apoptosis of PC cells. However, the potential mechanisms of ginseng in treating PC metastasis (PCM) have not been fully elucidated. In this study, we employed an integrated bioinformatics approach of network pharmacology analysis. By selecting common targets of diseases and drugs, a drug-component-target-disease network was constructed to analyze the biological functions and signaling pathways involved in the targets. A total of 6 PC samples were includedd, which were divided into primary PC group (PANC-1, n=3) and metastatic PC group. A total of 9263 differentially expressed genes (DEGs) and 14 PC target genes were identified. According to the network pharmacology analysis, we found that ginsenoside Rg3 was associated with the treatment of PCM and identified 6 potential targets. Among them, CD44, EGFR, KRAS, and PRNP were the main DEGs related to the treatment of PC by ginsenoside Rg3. These genes were mainly enriched in the Proteoglycans in Cancer pathway, and KRAS, EGFR, and CD44 were upregulated in the pathway, which may be affected by the ginsenoside Rg3. This provides a new direction for further research on the mechanisms of ginseng in PCM.
{"title":"Mechanisms of ginseng in pancreatic cancer metastasis","authors":"Zhaohong Wang, Xufan Cai, Shengzhang Lin","doi":"10.53730/ijhs.v7ns1.14490","DOIUrl":"https://doi.org/10.53730/ijhs.v7ns1.14490","url":null,"abstract":"It has been shown that ginsenosides can inhibit proliferation, migration, and invasion of pancreatic cancer (PC) cells, and promote apoptosis of PC cells. However, the potential mechanisms of ginseng in treating PC metastasis (PCM) have not been fully elucidated. In this study, we employed an integrated bioinformatics approach of network pharmacology analysis. By selecting common targets of diseases and drugs, a drug-component-target-disease network was constructed to analyze the biological functions and signaling pathways involved in the targets. A total of 6 PC samples were includedd, which were divided into primary PC group (PANC-1, n=3) and metastatic PC group. A total of 9263 differentially expressed genes (DEGs) and 14 PC target genes were identified. According to the network pharmacology analysis, we found that ginsenoside Rg3 was associated with the treatment of PCM and identified 6 potential targets. Among them, CD44, EGFR, KRAS, and PRNP were the main DEGs related to the treatment of PC by ginsenoside Rg3. These genes were mainly enriched in the Proteoglycans in Cancer pathway, and KRAS, EGFR, and CD44 were upregulated in the pathway, which may be affected by the ginsenoside Rg3. This provides a new direction for further research on the mechanisms of ginseng in PCM.","PeriodicalId":47093,"journal":{"name":"International Journal of Health Sciences-IJHS","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135198051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-04DOI: 10.53730/ijhs.v7ns1.14588
Loai. N. Said, Elham A. Al Atrash
Induction of labor may be necessary in around twenty-five to thirty percent of a woman's subsequent pregnancies when she has already given birth through cesarean section. During our research, the objective had been to ascertain the rate of spontaneous vaginal birth, rate of cesarean section, and rate of complications that followed the induction of labor with transcervical foley catheter in females who had previously had 1 cesarean section. This retrospective cohort trial was performed in the largest city in Palestine at a tertiary teaching hospital. In subsequent pregnancy, pregnant cases with a history of a prior CS delivery (n = 306) underwent labor induction at term with a Foley catheter. Women who underwent labor induction with transcervical foley catheter at Al-Ahli Hospital in Hebron, Palestine. From April 2017 until March 2020. Our research revealed that 46.7 percent of women had spontaneous vaginal births, 14.4 percent had assisted vaginal births, and one woman experienced uterine rupture. The frequency of postpartum hemorrhage is 30 percent, the most prevalent complication. 10 percent and 5 percent of mothers experienced intrapartum and postpartum infections, correspondingly. 5% of newborns had a confirmed infection, and there was one perinatal fatality related to uterine rupture.
{"title":"Foley catheter for induction of labor after cesarean section","authors":"Loai. N. Said, Elham A. Al Atrash","doi":"10.53730/ijhs.v7ns1.14588","DOIUrl":"https://doi.org/10.53730/ijhs.v7ns1.14588","url":null,"abstract":"Induction of labor may be necessary in around twenty-five to thirty percent of a woman's subsequent pregnancies when she has already given birth through cesarean section. During our research, the objective had been to ascertain the rate of spontaneous vaginal birth, rate of cesarean section, and rate of complications that followed the induction of labor with transcervical foley catheter in females who had previously had 1 cesarean section. This retrospective cohort trial was performed in the largest city in Palestine at a tertiary teaching hospital. In subsequent pregnancy, pregnant cases with a history of a prior CS delivery (n = 306) underwent labor induction at term with a Foley catheter. Women who underwent labor induction with transcervical foley catheter at Al-Ahli Hospital in Hebron, Palestine. From April 2017 until March 2020. Our research revealed that 46.7 percent of women had spontaneous vaginal births, 14.4 percent had assisted vaginal births, and one woman experienced uterine rupture. The frequency of postpartum hemorrhage is 30 percent, the most prevalent complication. 10 percent and 5 percent of mothers experienced intrapartum and postpartum infections, correspondingly. 5% of newborns had a confirmed infection, and there was one perinatal fatality related to uterine rupture.","PeriodicalId":47093,"journal":{"name":"International Journal of Health Sciences-IJHS","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135592504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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