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Financing Biomedical Innovation 生物医学创新融资
IF 3.2 3区 经济学 Q1 BUSINESS, FINANCE Pub Date : 2022-11-01 DOI: 10.1146/annurev-financial-031721-081537
A. Lo, Richard T. Thakor
We review the recent literature on financing biomedical innovation, with a specific focus on the drug development process and how it may be enhanced to improve outcomes. We begin by laying out stylized facts about the structure of the drug development process and its associated costs and risks, and we present evidence that the rate of discovery for life-saving treatments has declined over time while costs have increased. We make the argument that these structural features require drug development (i.e., biopharmaceutical) firms to rely on external financing and at the same time amplify market frictions that may hinder the ability of these firms to obtain financing, especially for treatments that may have large societal value relative to the benefits going to the firms and their investors. We then provide an overview of the evidence for various types of market frictions to which these drug development firms are exposed and discuss how these frictions affect their incentive to invest in the development of new drugs, leading to underinvestment in valuable treatments. In light of this evidence, numerous studies have proposed ways to overcome this funding gap, including the use of financial innovation. We discuss the potential of these approaches to improve outcomes.
我们回顾了最近关于资助生物医学创新的文献,特别关注药物开发过程以及如何加强它以改善结果。我们首先列出了有关药物开发过程结构及其相关成本和风险的程式化事实,我们提供的证据表明,随着时间的推移,拯救生命的治疗方法的发现率有所下降,而成本却有所增加。我们认为,这些结构特征要求药物开发(即生物制药)公司依赖外部融资,同时加剧市场摩擦,这可能会阻碍这些公司获得融资的能力,尤其是对于相对于公司及其投资者的利益可能具有巨大社会价值的治疗。然后,我们概述了这些药物开发公司面临的各种类型的市场摩擦的证据,并讨论了这些摩擦如何影响他们投资新药开发的动机,从而导致对有价值的治疗方法的投资不足。鉴于这一证据,许多研究提出了克服这一资金缺口的方法,包括利用金融创新。我们讨论了这些方法改善成果的潜力。
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引用次数: 8
A Review of China's Financial Markets 中国金融市场研究综述
IF 3.2 3区 经济学 Q1 BUSINESS, FINANCE Pub Date : 2022-09-02 DOI: 10.1146/annurev-financial-111620-010537
Grace X. Hu, Jiang Wang
The fast growth of China's economy has brought it not only to the center of the global economy but also to a transition point in its growth model, a transition from scale to efficiency, speed to sustainability, input driven to innovation led. How its financial markets can drive this new growth model and facilitate the transition are pressing challenges, for China and for the world. We provide a comprehensive review of China's financial markets, including government bonds, corporate/credit bonds, stocks, asset-backed securities, financial derivatives, investment management, and currency, focusing on their growth paths, distinct characteristics, and unique opportunities. Despite fast expansion at times, their development is often lagging behind market needs, uneven over time, and unbalanced across markets. This developmental pattern is driven mostly by the government's immediate policy objectives rather than by the markets' ultimate efficiency in serving their key functions, including liquidity provision, price discovery, and risk allocation. Expected final online publication date for the Annual Review of Financial Economics, Volume 13 is November 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
中国经济的快速发展,不仅使中国经济走到了世界经济的中心,而且使中国经济发展方式发生了转变,从规模驱动向效率驱动、速度驱动向可持续发展、投入驱动向创新驱动转变。中国的金融市场如何推动这种新的增长模式并促进转型,是中国和世界面临的紧迫挑战。我们全面回顾了中国的金融市场,包括政府债券、公司/信用债券、股票、资产支持证券、金融衍生品、投资管理和货币,重点关注它们的增长路径、独特特征和独特机遇。尽管有时发展迅速,但它们的发展往往滞后于市场需求,而且在时间上不平衡,在不同市场之间也不平衡。这种发展模式主要是由政府的直接政策目标驱动的,而不是由市场在服务其关键功能(包括流动性提供、价格发现和风险分配)方面的最终效率驱动的。《金融经济学年度评论》第13卷的最终在线出版日期预计为2022年11月。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。
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引用次数: 8
Nonbanks and Mortgage Securitization 非银行与抵押贷款证券化
IF 3.2 3区 经济学 Q1 BUSINESS, FINANCE Pub Date : 2022-08-17 DOI: 10.1146/annurev-financial-111620-025204
You Suk Kim, Karen Pence, Richard Stanton, J. Waldén, N. Wallace
This article reviews the dramatic growth of nonbank mortgage lending after the Global Financial Crisis, especially to borrowers with lower credit scores, and the related importance of mortgage-backed securitization. Our literature review suggests that the existing theoretical and empirical work on securitization is more relevant to bank than to nonbank lenders, thus leaving outstanding questions as to why nonbank market shares have increased to their current levels and how best to structure nonbank oversight. To highlight key differences in the mortgage-lending incentives of banks and nonbanks, we build a simple theoretical model of bank versus nonbank mortgage lending and use it to generate and test empirical hypotheses. We find, in particular, that loans issued by nonbanks are more likely to prepay early than loans issued by banks, the difference not explainable by nonbank borrowers prepaying more rationally. Using regulatory filings from nonbanks that are typically unavailable to academic researchers, we examine the balance sheets and liquidity and capital positions of large Ginnie Mae nonbank servicers, which face and pose more risk in the current mortgage system. We find that on average these servicers have reasonable liquidity and capital positions relative to standard regulatory thresholds, particularly in 2022:Q1 after a few quarters of elevated profits. However, some large Ginnie Mae servicers appear to have inadequate capital, as gauged by risk-based capital measures. If defaults rise on a large scale, the liquidity and capital positions of these servicers may amplify the disruption in the mortgage and housing markets. Expected final online publication date for the Annual Review of Financial Economics, Volume 13 is November 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
本文回顾了全球金融危机后非银行抵押贷款的急剧增长,特别是对信用评分较低的借款人,以及抵押贷款支持证券化的相关重要性。我们的文献综述表明,现有的证券化理论和实证工作与银行的相关性大于与非银行贷款人的相关性,因此留下了悬而未决的问题,即为什么非银行市场份额增加到目前的水平,以及如何最好地构建非银行监管。为了强调银行和非银行抵押贷款激励机制的关键差异,我们建立了一个银行与非银行抵押信贷的简单理论模型,并用它来生成和检验实证假设。我们特别发现,非银行发放的贷款比银行发放的更有可能提前还款,非银行借款人更合理地提前还款无法解释这一差异。利用学术研究人员通常无法获得的非银行监管文件,我们检查了大型Ginnie Mae非银行服务商的资产负债表、流动性和资本状况,这些服务商在当前的抵押贷款系统中面临并构成了更大的风险。我们发现,相对于标准监管阈值,这些服务商平均拥有合理的流动性和资本头寸,尤其是在2022年第一季度,在几个季度的利润上升之后。然而,根据基于风险的资本衡量标准,一些大型Ginnie Mae服务商的资本似乎不足。如果违约大规模增加,这些服务商的流动性和资本状况可能会加剧抵押贷款和住房市场的混乱。《金融经济学年度评论》第13卷预计最终在线出版日期为2022年11月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。
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引用次数: 4
The Effects of Public and Private Equity Markets on Firm Behavior 公共和私人股本市场对企业行为的影响
IF 3.2 3区 经济学 Q1 BUSINESS, FINANCE Pub Date : 2022-08-16 DOI: 10.1146/annurev-financial-052021-072939
Shai Bernstein
In this article, I review the theoretical and empirical literature on the effects of public and private equity markets on firm behavior, emphasizing the consequences that emerge from disclosure requirements, ownership concentration, and degree of firm standardization. While publicly listed firms benefit from a lower cost of capital, enabling increased focus on commercialization and profitability, they are less suited to pursue long-term risky investments. Privately held firms are better equipped to pursue innovative projects but face a higher cost of capital, which limits their growth. Complementarities between public and private equity markets can mitigate their respective limitations. Innovation in private equity markets supplements commercialization efforts of public firms, and demand for innovation by public firms accelerates entrepreneurial activity in private equity markets. I conclude by discussing directions for future research. Expected final online publication date for the Annual Review of Financial Economics, Volume 13 is November 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
在这篇文章中,我回顾了关于公开和私募股权市场对企业行为影响的理论和实证文献,强调了披露要求、所有权集中度和企业标准化程度所产生的后果。虽然上市公司受益于较低的资本成本,使其能够更多地关注商业化和盈利能力,但它们不太适合追求长期风险投资。私营企业更有能力追求创新项目,但面临更高的资本成本,这限制了它们的发展。公开市场和私人股本市场之间的互补性可以缓解它们各自的局限性。私募股权市场的创新补充了上市公司的商业化努力,上市公司对创新的需求加速了私募股权市场的创业活动。最后讨论了未来的研究方向。《金融经济学年度评论》第13卷的最终在线出版日期预计为2022年11月。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。
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引用次数: 6
Corporate Debt and Taxes 公司债务和税收
IF 3.2 3区 经济学 Q1 BUSINESS, FINANCE Pub Date : 2022-08-12 DOI: 10.1146/annurev-financial-101221-103806
Michelle Hanlon, Shane Heitzman
We provide updates to and perspectives on the enduring topic of debt and taxes. The recent decade brought us new empirical strategies, accounting rules, and tax laws. We discuss how these and other developments change our understanding of leverage and taxes. Overall, tax incentives still do not seem to have a consistent, first-order effect on corporate capital structure. This presents a puzzle as governments increasingly limit interest deductibility, citing its contribution to overleverage and distress. We discuss critical empirical challenges such as measurement, highlight issues surrounding assumptions about tax rates and real-world financing decisions, and offer insights and direction for future research. We conclude that rather than asking if taxes are a first-order driver of corporate capital structure, a more productive goal is a greater understanding of when tax incentives yield material effects on corporate capital structure. Expected final online publication date for the Annual Review of Financial Economics, Volume 13 is November 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
我们提供关于债务和税收这一长期话题的最新情况和观点。最近十年给我们带来了新的实证策略、会计规则和税法。我们讨论这些和其他发展如何改变我们对杠杆和税收的理解。总的来说,税收激励措施似乎仍然没有对公司资本结构产生一致的一阶效应。随着各国政府越来越多地限制利息减免,这就带来了一个难题,理由是它导致了过度杠杆化和困境。我们讨论了关键的实证挑战,如衡量,强调了围绕税率假设和现实世界融资决策的问题,并为未来的研究提供了见解和方向。我们得出的结论是,与其问税收是否是公司资本结构的一级驱动因素,不如更有效地了解税收激励何时对公司资本结构产生实质性影响。《金融经济学年度评论》第13卷预计最终在线出版日期为2022年11月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。
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引用次数: 3
Private Finance of Public Infrastructure 公共基础设施的私人融资
IF 3.2 3区 经济学 Q1 BUSINESS, FINANCE Pub Date : 2022-08-08 DOI: 10.1146/annurev-financial-111620-113307
E. Engel, R. Fischer, Alexander Galetovic
Public-private partnerships (PPPs) have emerged as an organizational form to provide public infrastructure. A key characteristic of PPPs is that private investors participate directly in individual infrastructure projects. The advantage of private finance is that it may improve incentives. However, private finance typically neither frees public funds nor enlarges the pool of viable projects. Private finance improves risk allocation if exogenous demand risk is assigned to the public, while endogenous risks are assigned to the private parties (PPPs and financiers), which provides strong incentives for efficiency. When funding for the project relies on user fees, variable term contracts can allocate risks efficiently, in contrast to allocation under fixed term contracts. The exploration of alternative financial contracts that allocate endogenous risks to private parties and determination of the optimal allocation of these risks among borrowers and lenders are potentially fruitful areas for future research. This line of research is probably relevant beyond infrastructure finance. Expected final online publication date for the Annual Review of Financial Economics, Volume 13 is November 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
公私伙伴关系(ppp)已经成为提供公共基础设施的一种组织形式。公私伙伴关系的一个关键特征是私人投资者直接参与单个基础设施项目。私人融资的优势在于它可以提高激励。然而,私人资金通常既不能腾出公共资金,也不能扩大可行项目的数量。如果将外生需求风险分配给公众,而将内生风险分配给私人各方(ppp和融资者),则私人融资可以改善风险分配,这为效率提供了强大的激励。当项目的资金依赖于用户费用时,与固定期限合同相比,可变期限合同可以有效地分配风险。探索将内生风险分配给私人方的替代金融合约,并确定这些风险在借款人和贷款人之间的最佳分配,是未来研究的潜在成果领域。这条研究路线可能与基础设施融资以外的领域相关。《金融经济学年度评论》第13卷的最终在线出版日期预计为2022年11月。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。
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引用次数: 0
The Pricing and Ownership of US Green Bonds 美国绿色债券的定价与持有
IF 3.2 3区 经济学 Q1 BUSINESS, FINANCE Pub Date : 2022-08-08 DOI: 10.1146/annurev-financial-111620-014802
Malcolm Baker, Daniel Bergstresser, George Serafeim, Jeffrey Wurgler
We review the pricing and ownership of green bonds, whose proceeds are used for environmentally focused purposes. After presenting an overview of the literature on green securities and green bonds in particular, we summarize the US corporate and municipal green bond markets. Green municipal bonds provide the best opportunity for detailed empirical study of how pricing and ownership differ from those of ordinary bonds. Green bonds are issued at a small premium of several basis points over similar ordinary bonds except when they are issued simultaneously with ordinary bonds from the same issuer; in that situation, a premium emerges over time on the secondary market. Green bonds, especially small or nearly riskless ones, are also more closely held than ordinary bonds. These facts are consistent with a simple framework that incorporates assets with nonpecuniary utility. Expected final online publication date for the Annual Review of Financial Economics, Volume 13 is November 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
我们审查了绿色债券的定价和所有权,其收益用于关注环境的目的。在概述了有关绿色证券和绿色债券的文献之后,我们总结了美国公司和市政绿色债券市场。绿色市政债券为详细实证研究其定价和所有权与普通债券的区别提供了最好的机会。绿色债券的发行价较同类普通债券高出几个基点,但与同一发行人的普通债券同时发行的情况除外;在这种情况下,随着时间的推移,二级市场上出现了溢价。绿色债券,尤其是小型或几乎没有风险的债券,也比普通债券更容易被投资者持有。这些事实与一个将资产与非货币效用结合起来的简单框架是一致的。《金融经济学年度评论》第13卷的最终在线出版日期预计为2022年11月。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。
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引用次数: 33
The Village Money Market Revealed: Financial Access and Credit Chain Links Between Formal and Informal Sectors 乡村货币市场揭示:正规部门和非正规部门之间的金融准入和信贷链联系
IF 3.2 3区 经济学 Q1 BUSINESS, FINANCE Pub Date : 2022-07-29 DOI: 10.1146/annurev-financial-012820-034126
Parit Sripakdeevong, R. Townsend
An all-or-nothing view of financial access leading to overly simplistic policy recommendations has been largely overturned in the data. Heterogeneity and explicit obstacles to trade are key aspects that need to be incorporated into models when looking at intermediate outcomes in the data. Networks in particular can amplify or work against policy interventions and do so in different directions for different groups at the same time. Work on village money markets allows us to better understand how these networks function, and how and why they can change with policy interventions. Nevertheless, though village economies are as sophisticated as those in New York financial markets, both suffer from familiar problems. One is reliance on relationships that segment markets and limit more universal benefits. A second problem is market contagion. Policy interventions facilitating financial access and the functioning of markets need to be guided by this stricter yet more realistic view. Expected final online publication date for the Annual Review of Financial Economics, Volume 13 is November 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
数据在很大程度上推翻了导致政策建议过于简单化的“要么全有要么全无”的金融准入观。异质性和明确的贸易障碍是在研究数据中的中间结果时需要纳入模型的关键方面。特别是网络可以扩大或反对政策干预,并同时在不同的方向上为不同的群体这样做。对农村货币市场的研究使我们能够更好地理解这些网络是如何运作的,以及它们如何以及为什么会随着政策干预而发生变化。然而,尽管乡村经济与纽约金融市场一样成熟,但两者都面临着相似的问题。一是依赖于细分市场的关系,限制了更普遍的利益。第二个问题是市场传染。促进金融准入和市场运作的政策干预需要以这种更严格但更现实的观点为指导。《金融经济学年度评论》第13卷的最终在线出版日期预计为2022年11月。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。
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引用次数: 0
The Economics of Liquidity Lines Between Central Banks 中央银行间流动性线的经济学
IF 3.2 3区 经济学 Q1 BUSINESS, FINANCE Pub Date : 2022-05-04 DOI: 10.1146/annurev-financial-111620-022146
Saleem Bahaj, R. Reis
Liquidity lines between central banks are a key part of the international financial safety net. In this review article, we lay out some of the economic questions that they pose. Research has provided answers to some of these questions, but many more require further research. Expected final online publication date for the Annual Review of Financial Economics, Volume 13 is November 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
各国央行之间的流动性限额是国际金融安全网的关键组成部分。在这篇评论文章中,我们列出了他们提出的一些经济问题。研究已经为其中一些问题提供了答案,但更多的问题需要进一步研究。《金融经济学年度评论》第13卷的最终在线出版日期预计为2022年11月。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。
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引用次数: 4
Some Simple Economics of Stablecoins 稳定币的一些简单经济学
IF 3.2 3区 经济学 Q1 BUSINESS, FINANCE Pub Date : 2022-04-28 DOI: 10.1146/annurev-financial-111621-101151
Christian Catalini,Alonso de Gortari,Nihar Shah
Stablecoins have the potential to drastically increase competition and innovation in financial services by reducing our reliance on traditional intermediaries. But they also introduce new challenges, as regulators rely on intermediaries to ensure financial stability, market integrity, and consumer protection. Because they operate at the interface between traditional banking and cryptocurrencies, stablecoins also represent an ideal setting for understanding the key trade-offs cryptocurrencies involve, and insights from robust stablecoin design and regulation are highly relevant for related innovations in decentralized finance (DeFi), nonfungible tokens, and Web3 protocols. In this review, we describe the following: key stablecoin design choices, from reserve composition to stability mechanism; legal claim against the issuer; noninterference with macroeconomic stability; and interoperability with public sector payment rails and central bank digital currencies. Last, we cover the key benefits of stablecoins in the context of real-time, low-cost programmable payments, financial inclusion, and DeFi. Expected final online publication date for the Annual Review of Financial Economics, Volume 13 is November 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
稳定币有可能通过减少我们对传统中介机构的依赖,大幅增加金融服务领域的竞争和创新。但它们也带来了新的挑战,因为监管机构依赖中介机构来确保金融稳定、市场诚信和消费者保护。因为它们在传统银行和加密货币之间的接口上运行,稳定币也代表了理解加密货币所涉及的关键权衡的理想环境,而稳健的稳定币设计和监管的见解与去中心化金融(DeFi)、不可替代代币和Web3协议的相关创新高度相关。在这篇综述中,我们描述了以下几点:稳定币的关键设计选择,从储备组成到稳定机制;对开证人的法律主张;不干涉宏观经济稳定;以及与公共部门支付轨道和央行数字货币的互操作性。最后,我们将介绍稳定币在实时、低成本可编程支付、普惠金融和DeFi背景下的主要优势。《金融经济学年度评论》第13卷的最终在线出版日期预计为2022年11月。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。
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引用次数: 0
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Annual Review of Financial Economics
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