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Intolerance of uncertainty and tolerance of ambiguity as distinct yet related predictors of student motivation in online learning: A systematic review 对不确定性的不容忍和对模糊性的容忍是在线学习中学生动机的不同但相关的预测因素:一项系统综述
IF 1.8 4区 心理学 Q3 PSYCHOLOGY, BIOLOGICAL Pub Date : 2026-01-13 DOI: 10.1016/j.lmot.2026.102243
Tianyuan Zhu, Songchu Liu
One of the issues that has attracted considerable attention in the field of educational psychology in recent years is the manner in which intolerance of uncertainty (IU) and tolerance of ambiguity (TA) shape student motivation within digital learning environments. IU, understood as a dispositional aversion to the stress prompted by uncertainty, and TA, characterized as a cognitive-affective trait that facilitates the acceptance of ambiguous situations, reveal conceptual overlaps in their processing of uncertain or ambiguous stimuli, as demonstrated by moderate correlations between them. In this systematic review, IU and TA are examined as complementary predictors of motivational dynamics, with IU often heightening vulnerability to declines in motivation and TA appearing to promote resilience and adaptability in such contexts. While related investigations have addressed aspects of resilience in language learning, the role of self-regulated learning technologies, and anxiety within digital courses, few systematic reviews have sought to synthesize the specific contributions of IU and TA to motivation in online learning. This review addresses that gap through an analysis of 18 empirical studies spanning the period from 2003 to 2025, drawn from databases including Web of Science, Scopus, ProQuest, ScienceDirect, and Google Scholar, and selected according to PRISMA guidelines. Criteria for inclusion encompassed an empirical focus on IU or TA in relation to motivation within online or blended learning settings, publication in English, and the exclusion of non-empirical works or those confined solely to face-to-face instruction. A thematic synthesis of these studies identifies six key dimensions that influence the nexus between IU/TA and motivation: (1) psychological well-being, (2) academic adjustment, (3) engagement and persistence, (4) instructional design, (5) technological affordances, and (6) socio-emotional moderators such as self-efficacy and empathy. The findings indicate that elevated levels of IU are associated with diminished motivation, satisfaction, and persistence, frequently mediated by factors like stress or anxiety, with moderate negative effect sizes observed across investigations involving more than 5000 participants, predominantly university students from varied regions including Turkey, China, and the USA. In contrast, higher TA seems connected to improved engagement, adaptability, and achievement, reflecting moderate positive effects as reported in the literature.
近年来,在教育心理学领域引起相当大关注的问题之一是,在数字学习环境中,不确定性不容忍(IU)和模糊性容忍(TA)如何塑造学生的动机。IU被理解为对不确定性引发的压力的性格厌恶,而TA则被描述为一种有助于接受模棱两可情况的认知情感特质,它们在处理不确定或模棱两可刺激时揭示了概念上的重叠,两者之间存在适度的相关性。在这篇系统综述中,IU和TA作为动机动力学的互补预测因子进行了研究,IU通常会增加对动机下降的脆弱性,而TA似乎会促进这种情况下的恢复力和适应性。虽然相关调查已经涉及语言学习的弹性、自我调节学习技术的作用以及数字课程中的焦虑等方面,但很少有系统的综述试图综合IU和TA对在线学习动机的具体贡献。本文通过对2003年至2025年期间的18项实证研究的分析,解决了这一差距,这些研究来自Web of Science、Scopus、ProQuest、ScienceDirect和谷歌Scholar等数据库,并根据PRISMA指南进行了选择。纳入标准包括对在线或混合学习环境中与动机相关的IU或TA的实证关注,以英语出版,以及排除非实证作品或仅局限于面对面教学的作品。这些研究的主题综合确定了影响IU/TA与动机之间关系的六个关键维度:(1)心理健康,(2)学术适应,(3)参与和坚持,(4)教学设计,(5)技术支持,以及(6)社会情感调节因子,如自我效能感和同理心。研究结果表明,IU水平升高与动机、满意度和持久性降低有关,通常由压力或焦虑等因素介导,在涉及5000多名参与者的调查中观察到适度的负面效应,主要是来自土耳其、中国和美国等不同地区的大学生。相比之下,较高的TA似乎与提高参与度、适应性和成就有关,反映了文献中报道的适度的积极影响。
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引用次数: 0
Pinoresinol diglucoside mitigates streptozotocin-induced cognitive decline in rats by regulating neurotransmitters, apoptosis and cytokines- NF-κB/ BDNF/ CREB/ caspase-3 pathway: Molecular docking study 松脂醇二葡糖苷通过调节神经递质、细胞凋亡和细胞因子- NF-κ b / BDNF/ CREB/ caspase-3通路减轻链脲霉素诱导的大鼠认知能力下降:分子对接研究
IF 1.8 4区 心理学 Q3 PSYCHOLOGY, BIOLOGICAL Pub Date : 2026-01-08 DOI: 10.1016/j.lmot.2026.102242
Shaktipal Patil , Hiren Chaudhary , Ujashkumar Shah
Diabetes mellitus (DM) is a widespread chronic disease affecting over 300 million people globally. Prolonged hyperglycemia leads to glucotoxicity, triggering neuroinflammation, neurodegeneration, and cognitive impairment. Pinoresinol diglucoside (PDG) exhibited potent neuroprotective action; however, its potential in mitigating streptozotocin (STZ)-induced cognitive impairment remains unexplored. This study aimed to evaluate PDG’s neuroprotective effects in STZ-induced cognitive deficits in male Wistar rats. The rats were randomly divided into five groups: Group I, non-diabetic control (normal saline, 1 ml/kg, p.o., twice daily for 30 days); Group II, diabetic control (STZ, 60 mg/kg, i.p., single dose, followed by normal saline, 1 ml/kg, i.p., twice daily for 30 days); Group III, PDG control (PDG, 10 mg/kg, p.o., twice daily for 30 days); Group IV, diabetic rats treated with PDG (5 mg/kg, p.o., twice daily for 30 days); and Group V, diabetic rats treated with PDG (10 mg/kg, p.o., twice daily for 30 days). DM was confirmed by elevated blood glucose levels (BGL), while cognitive function was assessed using the Y-maze and Morris water maze (MWM) tests. Following behavioural experiments, oxidative stress markers [malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), catalase (CAT)], cholinergic indices [acetylcholinesterase (AChE), choline acetyltransferase (ChAT)], neuroinflammatory cytokines [nuclear factor kappa-B (NF-κB), IL-6, interleukin-1β, tumor necrosis factor-α (TNF-α)], neurogenesis and cell proliferation markers [cAMP response element-binding protein (CREB), brain-derived neurotrophic factor (BDNF)], apoptosis parameter (caspase-3) and neurotransmitter dysregulation [acetylcholine (ACh), dopamine (DA)] was also validated. Molecular docking was performed to evaluate PDG’s interactions with key targets. Chronic PDG treatment significantly normalized BGL, body weight (BW), improved cognitive performance, and inhibited oxidative stress. It also attenuated cholinergic dysfunction, neuroinflammation, neurogenesis and cell proliferation and apoptosis while modulating neurotransmitter levels. Docking analysis revealed strong binding affinities of PDG to AChE, DA, caspase-3, CREB, BDNF, and NF-κB, supporting its anti-cholinesterase, anti-neuroinflammatory, and anti-apoptotic properties. These findings suggest PDG as a promising therapeutic candidate for DM-associated cognitive impairment, warranting further investigation.
糖尿病(DM)是一种广泛存在的慢性疾病,影响着全球3亿多人。长期高血糖导致糖毒性,引发神经炎症、神经变性和认知障碍。松脂醇二葡糖苷(PDG)表现出有效的神经保护作用;然而,它在减轻链脲佐菌素(STZ)引起的认知障碍方面的潜力仍未被探索。本研究旨在探讨PDG对stz诱导的雄性Wistar大鼠认知缺陷的神经保护作用。将大鼠随机分为5组:1组,非糖尿病对照组(生理盐水1 ml/kg, p.o,每日2次,连用30 d);II组,糖尿病对照组(STZ, 60 mg/kg, 1次给药,单次给药,随后加生理盐水,1 ml/kg, 1次给药,每日2次,连用30天);III组,PDG对照(PDG, 10 mg/kg, p.o,每日2次,连用30天);IV组,糖尿病大鼠给予PDG治疗(5 mg/kg, p.o,每日2次,连用30 d);V组糖尿病大鼠给予PDG(10 mg/kg, p.o,每日2次,连用30 d)。通过血糖水平升高(BGL)确认糖尿病,同时使用y迷宫和Morris水迷宫(MWM)测试评估认知功能。行为实验后,检测氧化应激标志物[丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽(GSH)、过氧化氢酶(CAT)]、胆碱能指标[乙酰胆碱酯酶(AChE)、胆碱乙酰转移酶(ChAT)]、神经炎症因子[核因子κ b (NF-κB)、IL-6、白细胞介素-1β、肿瘤坏死因子-α (TNF-α)]、神经发生和细胞增殖标志物[cAMP反应元件结合蛋白(CREB)、脑源性神经营养因子(BDNF)]、凋亡参数(caspase-3)和神经递质失调[乙酰胆碱(ACh),多巴胺(DA)]也得到了验证。通过分子对接来评估PDG与关键靶点的相互作用。慢性PDG治疗显著正常化BGL、体重(BW)、改善认知表现、抑制氧化应激。它还能减轻胆碱能功能障碍、神经炎症、神经发生和细胞增殖和凋亡,同时调节神经递质水平。对接分析显示,PDG与AChE、DA、caspase-3、CREB、BDNF和NF-κB具有较强的结合亲和力,支持其抗胆碱酯酶、抗神经炎症和抗凋亡的特性。这些发现表明,PDG是治疗dm相关认知障碍的有希望的候选药物,值得进一步研究。
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引用次数: 0
Expectancy-value theory: Linking uncertainty tolerance, grit, and academic engagement among EFL learners 期望价值理论:英语学习者的不确定性容忍、毅力和学习投入
IF 1.8 4区 心理学 Q3 PSYCHOLOGY, BIOLOGICAL Pub Date : 2026-01-07 DOI: 10.1016/j.lmot.2026.102241
Wang Jin, Zhou Jue
In high-stakes educational environments such as those in China, English as a foreign language (EFL) learners encounter significant psychological challenges. These include navigating uncertainty, fostering perseverance, and managing emotions to remain engaged in their studies. While individual constructs like tolerance of uncertainty, grit, and engagement have been studied, there is a notable lack of integrated structural models that investigate their connections with emotion regulation within the Chinese EFL context. This research explored the connections between academic emotion regulation, engagement, grit, and tolerance of uncertainty among 200 undergraduate EFL learners (ages 20–27) studying in English programs at various Chinese universities. Participants completed four self-report instruments and the collected data were analyzed using Structural Equation Modeling (PLS-SEM). The results confirmed the primary hypotheses: tolerance of uncertainty and academic engagement were positively associated with academic emotion regulation, whereas grit exhibited a notable negative impact. Sub-hypotheses examining specific dimensions revealed that stressful, incapability-in-action, negative/avoidance, and unfairness aspects of uncertainty, as well as the perseverance-in-effort and stability-of-interests dimensions of grit, and behavioral, emotional, and cognitive dimensions of engagement, all significantly influenced academic emotion regulation. These results highlight the central role of emotion regulation, grit, and uncertainty management in promoting EFL learners’ academic engagement, offering implications for targeted pedagogical interventions. The findings highlight the importance of teaching strategies that improve tolerance for uncertainty and foster engagement, which can enhance emotion regulation and possibly reduce the adverse effects of grit in high-stress situations.
在高风险的教育环境中,如在中国,英语作为外语(EFL)的学习者遇到了重大的心理挑战。这些包括驾驭不确定性,培养毅力,管理情绪以保持学习。虽然对不确定性容忍、毅力和投入等个体结构进行了研究,但在中国英语语境下,研究它们与情绪调节之间关系的综合结构模型明显缺乏。本研究以200名在中国多所大学英语专业学习的大学生(年龄20-27岁)为研究对象,探讨学业情绪调节、投入、毅力和对不确定性的容忍度之间的关系。参与者完成了四份自我报告工具,并使用结构方程模型(PLS-SEM)对收集的数据进行分析。结果证实了最初的假设:对不确定性的容忍和学业投入与学业情绪调节呈正相关,而毅力则表现出显著的负相关。研究特定维度的子假设表明,不确定性的压力、行动无能、消极/回避和不公平方面,以及毅力的努力毅力和兴趣稳定性方面,以及投入的行为、情感和认知方面,都显著影响学术情绪调节。这些结果强调了情绪调节、毅力和不确定性管理在促进英语学习者学业投入方面的核心作用,为有针对性的教学干预提供了启示。研究结果强调了提高对不确定性的容忍度和促进参与的教学策略的重要性,这可以增强情绪调节,并可能减少在高压力情况下毅力的不利影响。
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引用次数: 0
Subtle classroom cues and quantum interference in EFL reading comprehension and situational motivation: A quantum cognition-inspired study 英语阅读理解和情境动机中的微妙课堂线索和量子干扰:一个量子认知启发的研究
IF 1.8 4区 心理学 Q3 PSYCHOLOGY, BIOLOGICAL Pub Date : 2026-01-05 DOI: 10.1016/j.lmot.2025.102240
Yue Li, Yiyang Shi
This study explores the impact of subtle classroom cues, such as visual aids and peer interactions, on generating interference in English as a Foreign Language (EFL) learners’ reading comprehension and situational motivation, employing a Quantum Cognition-inspired framework to elucidate the non-linear, context-dependent dynamics of these processes. Drawing on quantum probability models, the research conceptualizes learners’ interpretive and situational motivational shifts as non-classical decision trajectories, offering a novel perspective that captures the probabilistic and emergent nature of cognitive and affective responses in complex learning environments, unlike traditional linear models. A six-week, mixed-methods, quasi-experimental study was conducted with 64 upper-intermediate Chinese EFL learners (N = 64), randomly assigned at the class level to experimental (cue-rich) and control (cue-minimal) groups. Reading comprehension and situational motivation were assessed through validated pre- and post-tests, with qualitative data gathered via group discussions and stimulated recall protocols. Quantitative analyses using a repeated-measures ANCOVA revealed significant fluctuations in reading comprehension and situational motivation in the experimental group, with specific deviations from classical expectations; for instance, in stance detection tasks, the observed probability of a particular interpretation was lower than the classically predicted probability, indicating negative interference; for instance, in stance detection tasks, the observed probability of a particular interpretation was lower than the classically predicted probability when visuals preceded peer comments, indicating negative interference, whereas positive interference occurred in the reverse sequence. Quantum probability modeling effectively captured these interference effects, demonstrating that learners’ responses were highly context-dependent and dynamically influenced by cue interactions. Qualitative findings, analyzed microgenetically, showed learners frequently shifted interpretive strategies mid-task, influenced by peers’ comments or visual prompts, with cue sequencing and order effects prominently shaping these shifts, as the initial presentation of visuals often anchored interpretations while subsequent peer inputs either reinforced or disrupted them, and motivational states oscillating between heightened engagement and temporary confusion. Notably, while task value and perceived competence increased significantly in the cue-rich condition, autonomy showed no significant change, highlighting a nuanced impact of cues on situational motivational dimensions. The findings suggest that subtle classroom cues can both scaffold and disrupt learning, depending on their alignment with learners’ interpretive frameworks.
本研究探讨了微妙的课堂线索,如视觉辅助和同伴互动,对英语作为外语(EFL)学习者的阅读理解和情境动机产生干扰的影响,采用量子认知启发的框架来阐明这些过程的非线性,情境依赖的动态。利用量子概率模型,该研究将学习者的解释和情境动机转变概念化为非经典决策轨迹,提供了一个新的视角,捕捉了复杂学习环境中认知和情感反应的概率性和突发性,这与传统的线性模型不同。本研究对64名中国中上英语学习者(N = 64)进行了为期6周的混合实验研究,按班级水平随机分为实验组(线索丰富组)和对照组(线索较少组)。阅读理解和情境动机通过经过验证的前后测试进行评估,并通过小组讨论和刺激回忆协议收集定性数据。使用重复测量ANCOVA的定量分析显示,实验组的阅读理解和情境动机有显著波动,与经典期望有特定偏差;例如,在姿态检测任务中,观察到的特定解释的概率低于经典预测的概率,表明负干扰;例如,在立场检测任务中,当视觉效果出现在同伴评论之前时,观察到的特定解释的概率低于经典预测的概率,这表明负面干扰,而积极干扰发生在相反的顺序。量子概率模型有效地捕获了这些干扰效应,表明学习者的反应高度依赖于上下文,并受到线索交互的动态影响。从微观角度分析的定性发现表明,受同伴的评论或视觉提示的影响,学习者在任务中经常改变解释策略,线索排序和顺序效应显著地塑造了这些转变,因为最初的视觉呈现通常锚定了解释,而随后的同伴输入要么加强要么破坏了解释,动机状态在高度投入和暂时困惑之间摇摆。值得注意的是,虽然任务价值和感知能力在线索丰富的条件下显著增加,但自主性没有显著变化,这突出了线索对情境动机维度的微妙影响。研究结果表明,微妙的课堂提示既可以促进学习,也可以破坏学习,这取决于它们与学习者的解释框架的一致性。
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引用次数: 0
How teachers’ motivational cues entangle with learners’ states to produce synchronized or conflicting engagement: Insights from a behaviorist reinforcement model 教师的动机线索如何与学习者的状态纠缠在一起,从而产生同步或冲突的投入:来自行为主义强化模型的见解
IF 1.8 4区 心理学 Q3 PSYCHOLOGY, BIOLOGICAL Pub Date : 2025-12-24 DOI: 10.1016/j.lmot.2025.102239
Xujing Xie , Yiming MA , Lei Liu
This study examines the ways in which teachers’ motivational cues influence learner engagement in English as a Foreign Language (EFL) classrooms, paying special attention to the dynamic alignment or misalignment with the emotional and cognitive states of learners. Utilizing behaviorist reinforcement theory, this research explores the intricate processes at the micro-level that influence how verbal and non-verbal cues can either promote synchronized engagement or lead to conflicts in interaction. Data were gathered through classroom observations, which included 12 sessions across three EFL classes in two universities, as well as semi-structured interviews conducted with 24 students and 6 teachers. The analysis identified four primary categories of motivational cues: positive reinforcement, which includes elements like praise and encouragement; corrective feedback, encompassing error correction and recasts; task-framing, which involves goal clarification and connecting tasks to future needs; and relational cues, such as humor and empathy. The states of learners were categorized into three fundamental dimensions: attentional focus, affective states, and task persistence. Observations indicated that synchronized engagement, characterized by sustained participation and collaborative interaction, took place when positive reinforcement and relational cues aligned with learners’ readiness and positive emotions. On the other hand, conflicting engagement, characterized by avoidance or frustration, arose from poorly timed corrective feedback or irrelevant task-framing. The findings emphasize the importance of aligning cues with the current states of learners to boost their engagement. The implications for teaching highlight the importance of providing timely and specific praise, balancing corrective feedback with encouragement, and framing tasks to underscore their relevance. These practices contribute to creating a supportive classroom environment that fosters sustained engagement. This study provides a richer insight into engagement as a collaborative and evolving process within EFL contexts.
本研究考察了教师的动机线索如何影响学习者在英语作为外语(EFL)课堂上的参与,特别关注与学习者的情绪和认知状态的动态一致或不一致。利用行为主义强化理论,本研究探讨了微观层面上影响语言和非语言线索如何促进同步参与或导致互动冲突的复杂过程。数据是通过课堂观察收集的,其中包括两所大学的三个英语班的12节课,以及对24名学生和6名教师进行的半结构化访谈。分析确定了四种主要的动机线索:积极强化,包括表扬和鼓励等因素;纠错反馈,包括纠错和重铸;任务框架,包括目标澄清和将任务与未来需求联系起来;以及关系线索,比如幽默和同理心。学习者的状态分为三个基本维度:注意焦点、情感状态和任务持久性。观察结果表明,当正向强化和关系线索与学习者的准备程度和积极情绪一致时,以持续参与和协作互动为特征的同步参与就会发生。另一方面,以回避或沮丧为特征的冲突性敬业度,是由时间不恰当的纠正反馈或不相关的任务框架引起的。研究结果强调了将提示与学习者的当前状态结合起来以提高他们的参与度的重要性。对教学的启示强调了提供及时和具体的表扬,平衡纠正反馈和鼓励,以及制定任务以强调其相关性的重要性。这些实践有助于创造一个支持性的课堂环境,促进持续的参与。这项研究提供了一个更丰富的见解,参与作为一个协作和发展过程在英语背景下。
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引用次数: 0
A social cognitive perspective on the relationship between intolerance of uncertainty and academic self-efficacy among EFL high school students 高中英语学生学业自我效能感与不确定性耐受性关系的社会认知视角
IF 1.8 4区 心理学 Q3 PSYCHOLOGY, BIOLOGICAL Pub Date : 2025-12-11 DOI: 10.1016/j.lmot.2025.102237
Liwei Long , Huiying Long
Academic Self-Efficacy (ASE) is acknowledged as a vital factor influencing student success, but the impact of personal variations in handling uncertainty has not been thoroughly examined. While earlier studies have identified connections between anxiety and reduced ASE, the precise role of Intolerance of Uncertainty (IU) and the cognitive-affective processes involved warrant additional exploration. To fill this gap, the current study utilized a mixed-methods approach to investigate the connection between IU and ASE in a sample of 274 high school students. During the quantitative phase, data gathered via validated self-report instruments were subjected to Pearson correlation and regression analysis. This analysis uncovered a strong negative correlation between IU and ASE, with prospective anxiety and inhibitory anxiety identified as significant predictors. To enhance these findings, thematic analysis was conducted on reflective journals from a carefully chosen subsample of 18 students, resulting in three significant themes that demonstrated how IU impacted learners' experiences: a) heightened threat appraisal of ambiguous tasks, (b) avoidance of challenging academic situations, and (c) impaired self-regulation strategies. The findings collectively emphasize the importance of IU as a significant psycho-affective element that negatively impacts students' academic confidence. This suggests that educational strategies aimed at enhancing tolerance of uncertainty, by fostering adaptive coping mechanisms and alleviating anxiety in uncertain situations, could be crucial in advancing ASE and bolstering students' overall academic well-being.
学术自我效能被认为是影响学生成功的重要因素,但个人差异在处理不确定性方面的影响尚未得到充分研究。虽然早期的研究已经确定了焦虑和ASE降低之间的联系,但不确定性不耐受(IU)和所涉及的认知情感过程的确切作用值得进一步探索。为了填补这一空白,目前的研究采用混合方法调查274名高中生的IU和ASE之间的联系。在定量阶段,通过有效的自我报告工具收集的数据进行Pearson相关和回归分析。该分析揭示了IU和ASE之间强烈的负相关,前瞻性焦虑和抑制性焦虑被认为是重要的预测因素。为了加强这些发现,我们对精心挑选的18名学生的反思期刊进行了专题分析,得出了三个重要的主题,证明了IU如何影响学习者的体验:a)对模棱两可任务的威胁评估增加,(b)回避具有挑战性的学术环境,(c)自我调节策略受损。这些发现共同强调了IU作为一个重要的心理情感因素的重要性,它对学生的学术信心产生了负面影响。这表明,旨在通过培养适应性应对机制和减轻不确定情况下的焦虑来增强对不确定性的容忍度的教育策略,对于促进ASE和增强学生的整体学术福祉至关重要。
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引用次数: 0
Neuroprotective effect of syringaldehyde in chronic unpredictable mild stress-induced model of depression 丁香醛对慢性不可预测轻度应激性抑郁症模型的神经保护作用
IF 1.8 4区 心理学 Q3 PSYCHOLOGY, BIOLOGICAL Pub Date : 2025-12-05 DOI: 10.1016/j.lmot.2025.102233
Priya P. Shejul , Gaurav M. Doshi

Purpose of the research

The impact of traumatic experiences and chronic stress on the onset of depression has been the subject of numerous studies. The major etiology that is thought to eventually lead to depression involves the monoamines, neurotrophic, and neuroinflammation hypothesis. The purpose of this research work was to evaluate the effect of Syringaldehyde (SA) in CUMS-induced animal model of depression. Male Swiss albino mice were used for this study. The CUMS model was used as an inducer and fluoxetine was used as a standard drug for the study purpose.

Principal results

The antidepressant activity was assessed by performing the Sucrose preference, Actophotometer, Tail suspension, and Forced swim tests. In addition, the levels of Serotonin, BDNF, and Interleukin-6 were estimated via the ELISA method using the mice whole brain homogenate. SA also showed an improvement against locomotor activity, immobility time, and sucrose preference in mice. For low, intermediate, and high doses of SA, the results were found to be significant (p < 0.05, p < 0.01, and p < 0.001). This study showed that the administration of SA exhibits anti-depressant activity, which is related, at least partly, to its elevated Brain-derived neurotrophic factor levels. The results showed that SA treatment increased neurotransmitters (serotonin) and reduced pro-inflammatory cytokines (IL-6).

Major conclusions

Thus, it can be concluded that at such 12.5 mg/kg, SA has notable anti-depressant effects. SA might be targeted to slow or prevent neurodegeneration and neuroinflammation in depression and potentially other neurodegenerative diseases.
研究目的创伤经历和慢性压力对抑郁症发病的影响一直是众多研究的主题。被认为最终导致抑郁症的主要病因包括单胺、神经营养和神经炎症假说。本研究的目的是评价丁香醛(SA)对cums诱导的抑郁症动物模型的影响。本研究采用雄性瑞士白化小鼠。以CUMS模型为诱导剂,氟西汀为标准药物。主要结果:抗抑郁活性通过蔗糖偏好、温度计、悬尾和强迫游泳测试来评估。此外,利用小鼠全脑匀浆,通过ELISA法测定血清素、BDNF和白细胞介素-6的水平。SA对小鼠的运动活性、静止时间和蔗糖偏好也有改善作用。对于低、中、高剂量SA,结果是显著的(p <; 0.05,p <; 0.01,p <; 0.001)。本研究表明,SA的施用表现出抗抑郁活性,这至少部分与其升高的脑源性神经营养因子水平有关。结果显示,SA治疗增加了神经递质(血清素),降低了促炎细胞因子(IL-6)。由此可见,12.5 mg/kg剂量下SA具有显著的抗抑郁作用。SA可能靶向减缓或预防抑郁症和潜在的其他神经退行性疾病的神经变性和神经炎症。
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引用次数: 0
Instructional framing and task ambiguity in motivated learning: A quantum-inspired experimental study on goal superposition and task engagement 动机学习中的教学框架与任务歧义:目标叠加与任务参与的量子启发实验研究
IF 1.8 4区 心理学 Q3 PSYCHOLOGY, BIOLOGICAL Pub Date : 2025-12-03 DOI: 10.1016/j.lmot.2025.102224
Huijun Li
This study investigates the combined effects of instructional framing (intrinsic mastery vs. extrinsic performance) and task ambiguity (low vs. high) on EFL learners' motivation, task value, and decision-making, addressing an underexplored gap in non-Western, high-stakes contexts. Drawing on Expectancy-Value Theory and quantum cognition's goal superposition, where conflicting aims (e.g., deep comprehension vs. exam success) coexist until framing resolves them, intrinsic approaches recast ambiguity as productive struggle to elevate engagement. Ninety-two intermediate Chinese EFL learners participated in a 2 × 2 factorial experiment, randomly assigned to one of four conditions over eight weeks. Mixed methods included pre/post questionnaires (task value, cognitive engagement), behavioral logs (decision latency, switching), diaries, and interviews. ANOVA revealed strong main effects of intrinsic framing on task value and engagement (η² > .70), moderated by ambiguity: high levels enhanced outcomes under intrinsic framing but triggered conflict and disengagement under extrinsic. Thematic analysis confirmed goal superposition as internal tensions, with intrinsic learners employing self-reflective strategies and extrinsic ones favoring external validation. Results advocate intrinsic mastery framing to harness ambiguity for EFL motivation, equipping educators with tools to foster autonomy, mitigate grade reliance, and promote resilient learning in exam-driven environments.
本研究探讨了教学框架(内在掌握vs外在表现)和任务模糊性(低vs高)对英语学习者动机、任务价值和决策的综合影响,解决了非西方高风险环境中未被充分探索的差距。利用期望价值理论和量子认知的目标叠加,其中冲突的目标(例如,深度理解与考试成功)共存,直到框架解决它们,内在方法将模糊性重新塑造为提高参与度的富有成效的斗争。92名中级中国英语学习者参加了一项2 × 2因子实验,在八周的时间里被随机分配到四种情况中的一种。混合方法包括前后问卷调查(任务价值、认知参与)、行为日志(决策延迟、转换)、日记和访谈。方差分析显示,内在框架对任务价值和敬业度有很强的主要影响(η²> .70),由模糊性调节:高水平的内在框架提高了结果,但在外在框架下引发了冲突和离职。主题分析证实了目标叠加是一种内部张力,内在学习者采用自我反思策略,外在学习者倾向于外部验证。研究结果主张内在掌握框架来利用英语动机的模糊性,为教育者提供工具来培养自主性,减轻对成绩的依赖,并在考试驱动的环境中促进弹性学习。
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引用次数: 0
Comparison of the impact of cooperative teaching (Jigsaw) method and lecture/teacher-based teaching method on buoyancy, self-efficacy, and help-seeking of English language learners 合作教学(拼图)法与授课/教师授课法对英语学习者的浮力、自我效能感和寻求帮助的影响比较
IF 1.8 4区 心理学 Q3 PSYCHOLOGY, BIOLOGICAL Pub Date : 2025-11-29 DOI: 10.1016/j.lmot.2025.102225
Xiaobing Fu , Shahrooz Sabbaghi , Siros Izadpanah
Teaching methods play a crucial role in shaping learners’ motivation, resilience, and academic performance; however, limited evidence exists regarding their comparative effects on academic buoyancy, self-efficacy, and help-seeking among EFL learners. Against this backdrop, this study compared the cooperative teaching (Jigsaw) method with the lecture/teacher-based method among 360 English language learners in Zanjan, Iran, who used the Top-Notch Fundamental textbook. The instruments utilized in the research included the Martin and Marsh Questionnaire, the Ryan and Pintrich Questionnaire, and the Morris Questionnaire. The statistical analyses included repeated measures ANOVA for examining differences between groups, the Kolmogorov-Smirnov test for evaluating data normality, and Levene's test for assessing variance homogeneity. Participants were divided into two groups: An experimental group using the Jigsaw method and a control group following a lecture-based method. The study was conducted over 12 sessions, focusing on key English language skills: reading, writing, listening, and speaking. The results indicated notable significant improvements in the experimental group in academic buoyancy, self-efficacy, and help-seeking behaviors. These results suggest that cooperative learning strategies, such as the Jigsaw method, can significantly enhance EFL learners' academic buoyancy, self-efficacy, and help-seeking behaviors.
教学方法在塑造学习者的学习动机、适应能力和学习成绩方面起着至关重要的作用;然而,关于它们在英语学习者的学业浮力、自我效能感和寻求帮助方面的比较影响,证据有限。在此背景下,本研究以伊朗赞詹360名使用Top-Notch basic教材的英语学习者为研究对象,比较了合作教学(Jigsaw)法与授课/教师授课法。研究中使用的工具包括Martin and Marsh问卷、Ryan and Pintrich问卷和Morris问卷。统计分析包括检验组间差异的重复测量方差分析,评估数据正态性的Kolmogorov-Smirnov检验,以及评估方差齐性的Levene检验。参与者被分为两组:实验组采用拼图法,对照组采用讲座法。这项研究进行了12次,重点关注关键的英语语言技能:阅读、写作、听力和口语。结果表明,实验组在学业浮力、自我效能和求助行为方面有显著改善。研究结果表明,以拼图教学法为代表的合作学习策略可以显著提高英语学习者的学习浮力、自我效能感和求助行为。
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引用次数: 0
Navigating open-ended STEM challenges under uncertainty: A mixed-method experimental study on grit, delay of gratification, and emotion regulation in problem-based learning 在不确定性下导航开放式STEM挑战:基于问题的学习中毅力、延迟满足和情绪调节的混合方法实验研究
IF 1.8 4区 心理学 Q3 PSYCHOLOGY, BIOLOGICAL Pub Date : 2025-11-26 DOI: 10.1016/j.lmot.2025.102223
Weijie Liu, Zhaoxia Lian
In a time marked by unpredictability and intricate challenges, equipping learners with the skills to endure, manage their emotions, and practice delayed gratification is essential. This mixed-method experimental study investigated the impact of open-ended science, technology, engineering, and mathematics (STEM) challenges under conditions of uncertainty on the grit, delay of gratification, and emotion regulation of Chinese EFL learners, all within a problem-based learning (PBL) framework. A total of 72 students aged 18–24 from China were randomly assigned to either an experimental group (EG) or a control group (CG), with both groups receiving instruction on the same STEM themes and integrated language skills over a period of four weeks. The EG tackled ill-structured, open-ended STEM tasks characterized by delayed feedback and significant uncertainty, whereas the CG focused on well-structured, closed-ended problems that were accompanied by immediate feedback. Validated instruments were utilized to collect quantitative data and open-ended survey was used to gather the qualitative data. The findings indicated that there were no notable differences observed during the pretest phase. Nevertheless, the results from the posttest indicated that the EG significantly surpassed the CG across all three variables: grit, emotion regulation, and delay of gratification. The thematic analysis of open-ended survey responses indicated that students in the EG exhibited enhanced motivation, emotional resilience, strategic collaboration, and cognitive engagement. In contrast, students in the CG reported a preference for structured instruction, yet demonstrated reduced levels of autonomy and collaboration. These findings highlight the importance of uncertainty-driven STEM education in enhancing learners' socio-emotional skills and self-regulation within problem-solving scenarios.
在一个充满不可预测性和复杂挑战的时代,让学习者掌握忍受、管理情绪和练习延迟满足的技能是至关重要的。本混合方法实验研究在基于问题的学习(PBL)框架下,调查了不确定条件下开放式科学、技术、工程和数学(STEM)挑战对中国英语学习者毅力、满足延迟和情绪调节的影响。来自中国的72名18-24岁的学生被随机分配到实验组(EG)或对照组(CG),两组在四周的时间里接受相同的STEM主题和综合语言技能的指导。EG解决结构不良、开放式的STEM任务,其特点是反馈延迟和显著的不确定性,而CG专注于结构良好、封闭式的问题,并伴有即时反馈。定量资料采用验证仪器收集,定性资料采用开放式问卷调查。结果表明,在测试前阶段没有观察到显着差异。然而,后测的结果表明,EG在毅力、情绪调节和延迟满足这三个变量上都明显超过了CG。开放式调查问卷的主题分析表明,EG中的学生表现出了更强的动机、情绪弹性、战略协作和认知参与。相比之下,CG组的学生报告了对结构化教学的偏好,但表现出了较低的自主和协作水平。这些发现强调了不确定性驱动的STEM教育在提高学习者的社会情感技能和在解决问题的情况下的自我调节方面的重要性。
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引用次数: 0
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Learning and Motivation
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