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Towards Excellence: Virtue and the Principle of Autonomy in Informed Consent for Clinical Trials. 走向卓越:美德与临床试验知情同意的自主原则。
IF 1.3 3区 哲学 Q3 ETHICS Pub Date : 2025-07-21 DOI: 10.1093/jmp/jhaf002
Alexander Montes

In this article, I argue that approximating virtues such as care and respectfulness are necessary to conduct an informed consent discussion for clinical trials adequately. I argue against Beauchamp and Childress' principlism insofar as it claims that virtues do not have "advantages" over the principle of respecting autonomy. When we elaborate what it means to facilitate autonomy in a consent discussion adequately, we find we are describing the virtues. This is because virtues do have an advantage over principles insofar as virtues provide us with rich descriptions of not only what we should do (respect autonomy), but how to do so (with the virtues of respectfulness, care, etc.). Thus, the principle of respecting autonomy points back to the virtues. I conclude by showing how cultivation of these virtues can help rectify well-known shortcomings in the informed consent process.

在这篇文章中,我认为,近似的美德,如关心和尊重是必要的,以充分进行临床试验的知情同意讨论。我反对波尚和柴尔德里斯的原则,因为它声称美德并不比尊重自治的原则有“优势”。当我们充分阐述在同意讨论中促进自主的意义时,我们发现我们是在描述美德。这是因为美德确实比原则有优势,因为美德不仅为我们提供了丰富的描述,告诉我们应该做什么(尊重自主),而且还告诉我们如何去做(尊重、关心等美德)。因此,尊重自治的原则指向美德。最后,我展示了培养这些美德如何有助于纠正知情同意过程中众所周知的缺点。
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引用次数: 0
Boundaries of Disease: Vagueness and Overdiagnosis. 疾病的界限:模糊和过度诊断。
IF 1.3 3区 哲学 Q3 ETHICS Pub Date : 2025-07-21 DOI: 10.1093/jmp/jhaf001
Christopher Boorse

In five related essays, Mary Jean Walker and Wendy Rogers, joined in one essay by Jenny Doust, defend various theses about the concept of disease. First, they argue "disease" is a cluster concept, not a "classically structured" one definable by necessary and sufficient conditions. Second, "disease" is vague, in the standard philosophical sense of having borderline cases. In fascinating detail, they argue that this vagueness shows up almost everywhere one looks among ordinary diseases, even if disease is taken to require dysfunction. Still, they conclude, vagueness per se need not be a problem because logicians and philosophers know several ways to handle it. Third, Rogers and Walker believe that the vagueness of "disease" is a clue to how to reduce the much-discussed medical problem of "overdiagnosis": the diagnosis of permanently harmless disease. Finally, they find my analysis of disease-the "biostatistical theory" (BST)-defective and dangerous in four different ways: it offers insufficient guidance on how to draw disease boundaries; it does not fit actual medical practice in doing so; it is ambiguous as to reference class; and it facilitates overdiagnosis. In this article, I freely concede the vagueness of disease, but argue that it is considerably less than Rogers and Walker suppose, and no threat to the BST in any case. I also rebut all their other charges of deficiency in my analysis.

在五篇相关的文章中,玛丽·简·沃克和温迪·罗杰斯,以及珍妮·道斯特的一篇文章,为各种关于疾病概念的论点辩护。首先,他们认为“疾病”是一个集群概念,而不是一个由必要和充分条件定义的“经典结构”概念。其次,“疾病”是模糊的,在标准的哲学意义上,有边缘病例。在引人入胜的细节中,他们认为这种模糊性在普通疾病中几乎无处不在,即使疾病被认为需要功能障碍。尽管如此,他们得出结论,模糊性本身不一定是个问题,因为逻辑学家和哲学家知道处理它的几种方法。第三,罗杰斯和沃克认为,“疾病”的模糊性是如何减少被广泛讨论的医学问题“过度诊断”的线索:对永久无害疾病的诊断。最后,他们发现我对疾病的分析——“生物统计学理论”(BST)——在四个不同的方面存在缺陷和危险:它在如何划定疾病界限方面提供的指导不足;这样做不符合实际的医疗实践;引用类是不明确的;这也会导致过度诊断。在这篇文章中,我坦率地承认疾病的模糊性,但认为它比罗杰斯和沃克想象的要少得多,而且无论如何都不会对英国夏令时构成威胁。我也反驳他们对我的分析有缺陷的所有其他指责。
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引用次数: 0
Depression and Autonomy in Physician-Assisted Suicide. 医生协助自杀中的抑郁和自主。
IF 1.3 3区 哲学 Q3 ETHICS Pub Date : 2025-07-21 DOI: 10.1093/jmp/jhaf005
Rina Tzinman

The standard view in medical practice is that patients have to be in an appropriate state of mind to count as autonomous. For example, according to the Macarthur Competency Assessment Tool for Treatment patients need to be able to: (1) communicate a choice; (2) factually understand the issues; (3) appreciate their situation; and (4) rationally manipulate information. These capacities are normally taken to be compromised by factors that may diminish one's capacity to properly assess one's situation. One of these diminishing factors is depression, which is especially relevant to decisions about assisted suicide or termination of treatment, since depression might contribute to the patient's leaning towards an action resulting in her death. I argue, however, that in certain circumstances, depression and the accompanying desires can be appropriate. Specifically, I demonstrate that even when depression is a factor in the patient's decision, it does not automatically undermine autonomy.

医疗实践中的标准观点是,患者必须处于适当的精神状态才能算作自主。例如,根据麦克阿瑟治疗能力评估工具,患者需要能够:(1)沟通选择;(2)实事求是地了解问题;(三)了解对方的处境;(4)合理处理信息。这些能力通常被认为受到一些因素的损害,这些因素可能会削弱一个人正确评估自己处境的能力。这些逐渐减少的因素之一是抑郁症,这与协助自杀或终止治疗的决定尤其相关,因为抑郁症可能会导致患者倾向于导致其死亡的行为。然而,我认为,在某些情况下,抑郁和伴随的欲望是适当的。具体来说,我证明了即使抑郁是影响患者决策的一个因素,它也不会自动削弱患者的自主权。
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引用次数: 0
The Morality of Assisted Dying. 协助死亡的道德。
IF 1.3 3区 哲学 Q3 ETHICS Pub Date : 2025-07-21 DOI: 10.1093/jmp/jhaf003
Stephen Richards

This essay analyzes the morality of assisted dying. To do this, it is necessary to recognize that assisted dying is the outworking of a larger process. This process unavoidably begins with the key moral conception of human dignity. Emphasis upon individualism in society has caused a restructuring of the dignity concept, changing what is most highly valued. This altered concept of dignity gives rise to assisted dying, yet is morally flawed. This is because it is an understanding of dignity that minimizes people's vulnerability, dismisses coercive forces that are brought into effect, encourages undue confidence in safeguards, and removes any sustained basis for respect of the individual. Autonomy, as the primary justification for assisted dying in contemporary society, is an abbreviated understanding of the restructured concept of dignity and therefore subject to the same criticisms. Assisted dying arises from a deficient and self-defeating foundation that mark it as immoral.

本文分析了协助死亡的道德问题。要做到这一点,有必要认识到辅助死亡是一个更大过程的结果。这一过程不可避免地始于人类尊严这一关键的道德观念。社会对个人主义的强调导致了尊严概念的重构,改变了最受重视的东西。这种改变了的尊严概念导致了协助死亡,但在道德上是有缺陷的。这是因为,只有对尊严的理解,才能最大限度地减少人的脆弱性,解除实施的强制力量,鼓励对保障措施的过分信任,并消除尊重个人的任何持久基础。作为当代社会协助死亡的主要理由,自主权是对重新构建的尊严概念的简略理解,因此受到同样的批评。辅助死亡产生于一个有缺陷和自我挫败的基础,这标志着它是不道德的。
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引用次数: 0
The Contradictions in the Criteria for Diagnosing Hypermobile Ehlers-Danlos Syndrome as Reflecting Some of the Philosophical Debates about the Threshold between the Normal and the Pathological. 超动性埃勒-丹洛斯综合征诊断标准的矛盾反映了一些关于正常与病理界限的哲学争论。
IF 1.3 3区 哲学 Q3 ETHICS Pub Date : 2025-07-21 DOI: 10.1093/jmp/jhaf004
Mar Rosàs Tosas

The arrival of some diagnoses tends to bring about relief because it validates suffering and grants access to social legitimization, medical resources, and economic aid. This is the case of the Ehlers-Danlos Syndrome (EDS), a pathology with multisystemic involvement characterized by general laxity. Patients find it difficult to secure a diagnosis of one of its types-hypermobile EDS-due to a lack of awareness among physicians, the multiple changes that the diagnostic criteria undergo, and their increasing restrictivity. Consequently, several patients are intermittently let in and out of the diagnostic label, which leads some members of family, friends, administration, working environment, and healthcare professionals to view these patients with a skeptical gaze. This article argues that the ambiguity and contradictions surrounding the diagnosis of hEDS partially result from and reflect two philosophical controversies on the nature of disease. First, the debate between naturalists and normativists. Second, the discussion on the line-drawing problem. It concludes by urging healthcare practitioners to tell patients the implications of these contradictions-mainly, that medicine can work, and does work, without definitive diagnostic criteria.

一些诊断的到来往往会带来缓解,因为它证实了痛苦,并给予获得社会合法化、医疗资源和经济援助的机会。ehers - danlos综合征(EDS)是一种以全身松弛为特征的多系统累及的病理。由于医生缺乏对其中一种类型的认识、诊断标准的多次变化以及其日益增加的限制性,患者发现很难获得诊断——超移动性eds。因此,一些患者被间歇性地允许进入和退出诊断标签,这导致一些家庭成员,朋友,行政部门,工作环境和医疗保健专业人员以怀疑的目光看待这些患者。本文认为,围绕hEDS诊断的歧义和矛盾部分源于并反映了两种关于疾病本质的哲学争论。首先是自然主义者和规范主义者之间的争论。第二,关于划线问题的讨论。最后,它敦促医疗保健从业者告诉病人这些矛盾的含义——主要是,没有明确的诊断标准,药物可以起作用,而且确实起作用。
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引用次数: 0
Why Nonidentity Is Not a Problem: Parfitian Defence of Clinicians Refusing to Provide Assisted Reproductive Technologies. 为什么不认同不是问题:拒绝提供辅助生殖技术的临床医生的辩护。
IF 1.3 3区 哲学 Q3 ETHICS Pub Date : 2025-05-04 DOI: 10.1093/jmp/jhaf010
Georgina Hall

An accepted argument in reproductive rights literature holds that the welfare of future children is irrelevant in the provision of assisted reproductive technology (ART). A foundational philosophical concept underpinning such dismissal appeals to the "non-identity" problem. This argument holds that a future ART child's overriding interest lies in being born. I challenge this argument, suggesting it is a shallow and selective interpretation of the concept that narrowly applies the "person-affecting" harm principle to future ART children. I suggest a more extensive reading of the "non-identity" problem defends the opposite argument-that dismissing child welfare concerns in ART provision is wrong. In line with the work of one of the key architects of the "non-identity" problem, I formulate four Parfit-style arguments that justify clinician refusal of treatment. The key substantive claim of this paper is that delay or denial of ART is morally defensible within the "non-identity" problem paradigm in some instances.

生殖权利文献中一个公认的论点认为,未来儿童的福利与辅助生殖技术(ART)的提供无关。支撑这种驳斥的一个基本哲学概念是“非同一性”问题。这种观点认为,未来接受抗逆转录病毒治疗的孩子最重要的利益在于他们的出生。我对这一观点提出质疑,认为这是对概念的一种肤浅和选择性的解释,将“影响人”的伤害原则狭隘地应用于未来的抗逆转录病毒治疗儿童。我建议对“非同一性”问题进行更广泛的解读,以捍卫相反的论点——在ART提供中忽视儿童福利问题是错误的。根据“非同一性”问题的主要架构师之一的工作,我提出了四个帕菲特式的论点,为临床医生拒绝治疗辩护。本文的关键实质主张是,在某些情况下,在“非同一性”问题范式中,延迟或拒绝抗逆转录病毒治疗在道德上是可以辩护的。
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引用次数: 0
Rejoinder to Dominiak and Wysocki on Evictionism. 对多米尼克和威索基关于驱逐主义的回答。
IF 1.3 3区 哲学 Q3 ETHICS Pub Date : 2025-04-22 DOI: 10.1093/jmp/jhaf007
Walter E Block

Dominiak and Wysocki (2023, hence, DW) offer a series of criticisms of my analysis of abortion: evictionism, which is a compromise position between the pro-life and the pro-choice viewpoints. The present article is a response to DW.

Dominiak和Wysocki(2023,因此,DW)对我对堕胎的分析提出了一系列批评:驱逐主义,这是一种介于反堕胎和支持选择观点之间的妥协立场。本文是对德国之声的回应。
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引用次数: 0
First-Person Authorization and Family Objections to Organ Donation. 第一人称授权和家属反对器官捐赠。
IF 1.3 3区 哲学 Q3 ETHICS Pub Date : 2025-04-18 DOI: 10.1093/jmp/jhaf008
Ana S Iltis, Briana Denny

In the United States, individuals who authorize organ donation through various mechanisms make a legally binding decision that only they may revoke. When a person who has given first-person authorization for organ donation becomes eligible to donate organs, according to laws across the United States, their next-of-kin should be informed, not asked, about the impending organ procurement. Despite this, sometimes families are asked for permission to proceed with donation, or they express unsolicited objections to donation. Some scholars and activists argue for the importance of honoring first-person authorization and not accepting what are sometimes called "family overrides" or "family vetoes" of donation. We consider two arguments for this view, the respect-for-wishes and the prevent-harm arguments and defend a more nuanced approach to family objections to organ donation in the presence of first-person authorization. We also examine the role of families or legally authorized representatives in making decisions regarding premortem interventions for potential donors who are not yet deceased. We argue that such decisions are about living patients and should be treated like all other clinical decisions that legally authorized representatives make for incapacitated living patients.

在美国,通过各种机制授权器官捐赠的个人做出了具有法律约束力的决定,只有他们自己才能撤销。根据美国各地的法律,当给予器官捐赠第一人称授权的人有资格捐赠器官时,他们的近亲应该被告知即将进行的器官获取,而不是被询问。尽管如此,有时还是要征得家属的同意,或者他们主动表示反对捐赠。一些学者和活动人士认为,尊重第一人称授权的重要性,不接受有时被称为“家庭凌驾”或“家庭否决”的捐赠。我们考虑了这一观点的两个论点,即尊重意愿和防止伤害的论点,并为家庭反对在第一人称授权下进行器官捐赠的更微妙的方法辩护。我们还研究了家庭或合法授权代表在决定对尚未死亡的潜在捐赠者进行死前干预时所起的作用。我们认为,这些决定是关于活着的病人的,应该像所有其他临床决定一样被对待,这些决定是由合法授权的代表为没有行为能力的活着的病人做出的。
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引用次数: 0
Destroy, Let Die, or Grow the Embryo Further? Puzzles Raised by the 14-Day Rule and Other Time Limits for Embryo Research. 摧毁胚胎,让它死去,还是让它继续生长?14天规则和胚胎研究的其他时间限制带来的困惑。
IF 1.3 3区 哲学 Q3 ETHICS Pub Date : 2025-04-18 DOI: 10.1093/jmp/jhaf006
Helen Watt

Supporting the 14-day rule or other embryo research time limits raises puzzling questions for those wishing to protect older embryos (or indeed, more developed human subjects). What are, or should be, our more immediate aims in setting or implementing such time limits? May death for the research subject be sought as the limit approaches? If the embryo is worth protecting, is it in the embryo's interests to be sustained by a scientist, albeit for instrumental reasons? Should embryo research, including observational research, be prevented, despite the embryo's interest in living further? This paper argues that the aim to prevent more prolonged experimentation, while reasonable, should not be promoted via the means of deliberately arranging the embryo's death. Time limits can encourage such intentions, even if they do not require them. The case is made that while a regulatory status quo should not be amended in favor of a worse alternative, there are several morally preferable options with which the 14-day rule or more permissive alternatives might be replaced.

支持14天规则或其他胚胎研究时间限制,给那些希望保护较老胚胎(或更成熟的人类受试者)的人提出了令人困惑的问题。在设定或执行这些时间限制时,我们更直接的目标是什么,或者应该是什么?当极限接近时,是否可以寻求研究对象的死亡?如果胚胎值得保护,那么由科学家来维持胚胎是否符合胚胎的利益,尽管是出于工具上的原因?胚胎研究,包括观察性研究,是否应该被阻止,尽管胚胎想要活得更远?本文认为,防止更长时间实验的目的虽然合理,但不应通过故意安排胚胎死亡的方式来促进。时间限制可以鼓励这样的意图,即使它们并不需要。这种情况下,虽然监管现状不应该被修改以支持更糟糕的替代方案,但有几个道德上更可取的选择,可以用14天规则或更宽容的替代方案来取代。
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引用次数: 0
Hypochondriacal Doubt: How It Devours Itself Despite Its Seeming Consistence. 疑病症:它如何吞噬自己,尽管它看似一致。
IF 1.3 3区 哲学 Q3 ETHICS Pub Date : 2025-04-16 DOI: 10.1093/jmp/jhaf009
José María Ariso

Hypochondriasis-currently split into the "somatic symptom disorder" and the "illness anxiety disorder" diagnoses-is characterized by the patient's conviction that minor symptoms are signs of a severe illness, even after undertaking medical exams that could not detect any disorder. In this paper, I analyze the basic hypochondriacal doubt, that is, calling into question the practitioners' reassurance that no evidence of serious disease has been found to account for his symptom. Specifically, I take as reference Ludwig Wittgenstein's posthumous work, On Certainty, to explain how a genuine doubt differs from a behavior that merely seems to be a doubt. On this basis, I clarify in which respects hypochondriacal doubt turns out to be a consistent doubt. But then, I reveal why such doubt makes no sense. Lastly, I show how medical and nurse staff as well as the hypochondriac's family can progressively help him overcome the aforementioned doubt.

疑病症——目前分为“躯体症状障碍”和“疾病焦虑障碍”两种诊断——的特点是患者坚信轻微症状是严重疾病的征兆,即使在进行了无法发现任何疾病的医学检查之后。在这篇论文中,我分析了基本的疑病症怀疑,也就是说,对医生保证没有发现严重疾病的证据来解释他的症状提出质疑。具体来说,我参考了路德维希·维特根斯坦(Ludwig Wittgenstein)的遗作《论确定性》(On Certainty)来解释真正的怀疑与看似怀疑的行为有何不同。在此基础上,我澄清了疑病症在哪些方面被证明是一种一致性怀疑。但随后,我揭示了为什么这种怀疑毫无意义。最后,我展示了医护人员以及疑病症患者的家人如何逐步帮助他克服上述疑虑。
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引用次数: 0
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Journal of Medicine and Philosophy
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