首页 > 最新文献

Journal of Medicine and Philosophy最新文献

英文 中文
Impairment Arguments, Interests, and Circularity. 减值论证、利益和循环性。
IF 1.3 3区 哲学 Q3 ETHICS Pub Date : 2024-09-03 DOI: 10.1093/jmp/jhae023
Stephen Napier

A common justification for abortion rights is that the death of the fetus does not violate any of the fetus's time-relative interests. The time-relative interest account (TRIA) of harm and wrongdoing tells us that a necessary condition for harming someone is that his or her time-relative interests are frustrated. Regarding the justification for abortion, this account falls prey to impairment arguments. Impairment arguments entertain cases of prenatal injury, such as the mother using illicit drugs that disable the child. The intuition is that the child who is born with such disabilities is harmed by the mother's drug use. But it is unclear what time-relative interest is violated in cases of prenatal harm. Typical responses to impairment arguments point out that the abortion case is different because the child does not exist to experience such harms; but in prenatal injury + survival cases, the child does live to experience those harms. Thus, the TRIA justification for abortion is not impugned by impairment counter-examples. This article argues that this response to impairment arguments is viciously circular. The response must say that so long as you kill the child, no harm is done. But this assumes that killing itself is morally inconsequential and is not itself a case of harm. The response to impairment arguments, then, assumes the permissibility of abortion.

堕胎权的一个常见理由是,胎儿的死亡不会侵犯胎儿的任何时间相关利益。关于伤害和不法行为的时间相关利益论(TRIA)告诉我们,伤害某人的必要条件是他或她的时间相关利益受挫。关于堕胎的正当性,这一观点成为损害论点的牺牲品。损害论点认为存在产前伤害的情况,例如母亲使用违禁药物使孩子丧失能力。其直觉是,天生残疾的孩子受到了母亲使用毒品的伤害。但是,在产前伤害的情况下,什么时间相关利益受到侵犯还不清楚。对损伤论点的典型回应指出,堕胎的情况不同,因为孩子并不存在,不会经历这些伤害;但在产前损伤+存活的情况下,孩子确实活着经历了这些伤害。因此,堕胎的 TRIA 理由不会受到损伤反例的质疑。本文认为,这种对损害论点的回应是恶性循环。回应必须说,只要你杀死了孩子,就没有伤害。但这是假定杀人本身在道德上无足轻重,其本身并不是一种伤害。因此,对损害论点的回应假定了堕胎的可允许性。
{"title":"Impairment Arguments, Interests, and Circularity.","authors":"Stephen Napier","doi":"10.1093/jmp/jhae023","DOIUrl":"10.1093/jmp/jhae023","url":null,"abstract":"<p><p>A common justification for abortion rights is that the death of the fetus does not violate any of the fetus's time-relative interests. The time-relative interest account (TRIA) of harm and wrongdoing tells us that a necessary condition for harming someone is that his or her time-relative interests are frustrated. Regarding the justification for abortion, this account falls prey to impairment arguments. Impairment arguments entertain cases of prenatal injury, such as the mother using illicit drugs that disable the child. The intuition is that the child who is born with such disabilities is harmed by the mother's drug use. But it is unclear what time-relative interest is violated in cases of prenatal harm. Typical responses to impairment arguments point out that the abortion case is different because the child does not exist to experience such harms; but in prenatal injury + survival cases, the child does live to experience those harms. Thus, the TRIA justification for abortion is not impugned by impairment counter-examples. This article argues that this response to impairment arguments is viciously circular. The response must say that so long as you kill the child, no harm is done. But this assumes that killing itself is morally inconsequential and is not itself a case of harm. The response to impairment arguments, then, assumes the permissibility of abortion.</p>","PeriodicalId":47377,"journal":{"name":"Journal of Medicine and Philosophy","volume":" ","pages":"470-480"},"PeriodicalIF":1.3,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11369812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
To Know Me Is to Exonerate Me: Appeals to Character in Defense of the Willowbrook Hepatitis Study. 认识我就是为我开脱罪责:为威洛布鲁克肝炎研究辩护的人格诉求》。
IF 1.3 3区 哲学 Q3 ETHICS Pub Date : 2024-09-03 DOI: 10.1093/jmp/jhae024
John Lynch

The Willowbrook Hepatitis Study is one of the best-known examples of unethical medical research, but the research has always had defenders. One of the more intriguing defenses continually used was that critics did not know the researchers on the study and, therefore, could not assess their ethics. This essay traces the appeal to the researchers' characters across published research and archival sources from the 1960s through today. These appeals reflect the observation as old as Aristotle that one of the most potent modes of persuasion is ethos or character. The specific types of character in these appeals develop out of the paternalistic nature of clinical and research practice in the mid-twentieth century. If the individual physician is the locus of medical judgment, then the physician's character becomes a key concern for bioethics. These appeals still appear and have implications for bioethics in the present day.

威洛布鲁克肝炎研究是最著名的不道德医学研究案例之一,但这项研究一直有辩护者。其中一个更耐人寻味的辩护理由是,批评者并不了解这项研究的研究人员,因此无法评估他们的道德水平。这篇文章追溯了从 20 世纪 60 年代至今发表的研究报告和档案资料中对研究人员人品的呼吁。这些诉求反映了亚里士多德的古老观点,即最有力的说服方式之一是道德或品格。这些诉求中的特定品格类型源于二十世纪中叶临床和研究实践中的家长式作风。如果医生个人是医学判断的中心,那么医生的品格就成为生命伦理学关注的重点。这些诉求在今天依然存在,并对生命伦理学产生影响。
{"title":"To Know Me Is to Exonerate Me: Appeals to Character in Defense of the Willowbrook Hepatitis Study.","authors":"John Lynch","doi":"10.1093/jmp/jhae024","DOIUrl":"10.1093/jmp/jhae024","url":null,"abstract":"<p><p>The Willowbrook Hepatitis Study is one of the best-known examples of unethical medical research, but the research has always had defenders. One of the more intriguing defenses continually used was that critics did not know the researchers on the study and, therefore, could not assess their ethics. This essay traces the appeal to the researchers' characters across published research and archival sources from the 1960s through today. These appeals reflect the observation as old as Aristotle that one of the most potent modes of persuasion is ethos or character. The specific types of character in these appeals develop out of the paternalistic nature of clinical and research practice in the mid-twentieth century. If the individual physician is the locus of medical judgment, then the physician's character becomes a key concern for bioethics. These appeals still appear and have implications for bioethics in the present day.</p>","PeriodicalId":47377,"journal":{"name":"Journal of Medicine and Philosophy","volume":" ","pages":"499-511"},"PeriodicalIF":1.3,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141159372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is Cryocide an Ethically Feasible Alternative to Euthanasia? 冷冻杀戮在伦理上是否可以替代安乐死?
IF 1.3 3区 哲学 Q3 ETHICS Pub Date : 2024-09-03 DOI: 10.1093/jmp/jhae027
Gabriel Andrade, Maria Campo Redondo

While some countries are moving toward legalization, euthanasia is still criticized on various fronts. Most importantly, it is considered a violation of the medical ethics principle of non-maleficence, because it actively seeks a patient's death. But, medical ethicists should consider an ethical alternative to euthanasia. In this article, we defend cryocide as one such alternative. Under this procedure, with the consent of terminally-ill patients, their clinical death is induced, in order to prevent the further advance of their brain's deterioration. Their body is then cryogenically preserved, in the hope that in the future, there will be a technology to reanimate it. This prospect is ethically distinct from euthanasia if a different criterion of death is assumed. In the information-theoretic criterion of death, a person is not considered dead when brain and cardiopulmonary functions cease, but rather, when information constituting psychology and memory is lost.

尽管一些国家正朝着安乐死合法化的方向迈进,但安乐死仍然受到各方面的批评。最重要的是,安乐死被认为违反了 "非恶意 "的医学伦理原则,因为它主动寻求病人的死亡。但是,医学伦理学家应该考虑安乐死的伦理替代方案。在本文中,我们将为冷冻疗法辩护,将其视为一种替代方案。根据这一程序,在临终病人的同意下,诱导他们临床死亡,以防止他们的大脑进一步恶化。然后,他们的遗体被低温保存起来,希望将来能有技术使其重新复活。如果假定死亡的标准不同,这种前景在伦理上就与安乐死不同。根据信息论的死亡标准,一个人并不是在大脑和心肺功能停止时才被视为死亡,而是在构成心理和记忆的信息丧失时才被视为死亡。
{"title":"Is Cryocide an Ethically Feasible Alternative to Euthanasia?","authors":"Gabriel Andrade, Maria Campo Redondo","doi":"10.1093/jmp/jhae027","DOIUrl":"10.1093/jmp/jhae027","url":null,"abstract":"<p><p>While some countries are moving toward legalization, euthanasia is still criticized on various fronts. Most importantly, it is considered a violation of the medical ethics principle of non-maleficence, because it actively seeks a patient's death. But, medical ethicists should consider an ethical alternative to euthanasia. In this article, we defend cryocide as one such alternative. Under this procedure, with the consent of terminally-ill patients, their clinical death is induced, in order to prevent the further advance of their brain's deterioration. Their body is then cryogenically preserved, in the hope that in the future, there will be a technology to reanimate it. This prospect is ethically distinct from euthanasia if a different criterion of death is assumed. In the information-theoretic criterion of death, a person is not considered dead when brain and cardiopulmonary functions cease, but rather, when information constituting psychology and memory is lost.</p>","PeriodicalId":47377,"journal":{"name":"Journal of Medicine and Philosophy","volume":" ","pages":"443-457"},"PeriodicalIF":1.3,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disability and Achievement: A Reply to Campbell, Nyholm, and Walter. 残疾与成就:答复坎贝尔、尼霍尔姆和沃尔特》。
IF 1.3 3区 哲学 Q3 ETHICS Pub Date : 2024-09-03 DOI: 10.1093/jmp/jhae026
Ian D Dunkle

In this article, I explore the impact of disability on one of life's goods: achievement. Contra Campbell, Nyholm, and Walter. I argue that construing the magnitude of achievements in terms of subjective effort trivializes what it means to achieve. This poses a problem for the authors' argument that disability, in general, does not reduce access to this good. I draw on an alternative construal of achievement that I have proposed elsewhere to show that, indeed, many disabilities do not restrict access to achievement. I defend this argument against an objection that it problematically relativizes the achievements of persons with disability, and I close with general lessons for future work.

在本文中,我将探讨残疾对人生财富之一--成就--的影响。与坎贝尔、尼霍姆和沃尔特的观点相反。我认为,从主观努力的角度来解释成就的大小会轻视成就的意义。这就给作者的论点带来了问题,即一般来说,残疾并不会减少获得这种商品的机会。我借鉴了我在其他地方提出的对成就的另一种解释,以证明许多残疾确实没有限制对成就的获取。有人反对这一论点,认为它将残疾人的成就相对化,我为这一论点进行了辩护。
{"title":"Disability and Achievement: A Reply to Campbell, Nyholm, and Walter.","authors":"Ian D Dunkle","doi":"10.1093/jmp/jhae026","DOIUrl":"10.1093/jmp/jhae026","url":null,"abstract":"<p><p>In this article, I explore the impact of disability on one of life's goods: achievement. Contra Campbell, Nyholm, and Walter. I argue that construing the magnitude of achievements in terms of subjective effort trivializes what it means to achieve. This poses a problem for the authors' argument that disability, in general, does not reduce access to this good. I draw on an alternative construal of achievement that I have proposed elsewhere to show that, indeed, many disabilities do not restrict access to achievement. I defend this argument against an objection that it problematically relativizes the achievements of persons with disability, and I close with general lessons for future work.</p>","PeriodicalId":47377,"journal":{"name":"Journal of Medicine and Philosophy","volume":" ","pages":"481-487"},"PeriodicalIF":1.3,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141097145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organ Donation by the Imminently Dead: Addressing the Organ Shortage and the Dead Donor Rule. 濒死者器官捐献:解决器官短缺和死亡捐献者规则。
IF 1.3 3区 哲学 Q3 ETHICS Pub Date : 2024-09-03 DOI: 10.1093/jmp/jhae028
Sarah Chen, Robert M Sade, John W Entwistle

The dead donor rule (DDR) has facilitated the saving of hundreds of thousands of lives. Recent advances in heart donation, however, have exposed how DDR has limited donation of all organs. We propose advancing the moment in the dying process at which death can be determined to increase substantially the supply of organs for transplantation. We justify this approach by identifying certain flaws in the Uniform Determination of Death Act and proposing a modification of that law that permits earlier procurement of healthier organs in greater numbers.

死亡捐献者规则(DDR)挽救了成千上万人的生命。然而,最近在心脏捐献方面取得的进展暴露了死亡捐献规则如何限制了所有器官的捐献。我们建议将确定死亡的时间提前,以大幅增加用于移植的器官供应。我们指出了《统一死亡判定法》中的某些缺陷,并建议对该法进行修改,允许更早地获取更多的健康器官,从而证明这种做法是合理的。
{"title":"Organ Donation by the Imminently Dead: Addressing the Organ Shortage and the Dead Donor Rule.","authors":"Sarah Chen, Robert M Sade, John W Entwistle","doi":"10.1093/jmp/jhae028","DOIUrl":"10.1093/jmp/jhae028","url":null,"abstract":"<p><p>The dead donor rule (DDR) has facilitated the saving of hundreds of thousands of lives. Recent advances in heart donation, however, have exposed how DDR has limited donation of all organs. We propose advancing the moment in the dying process at which death can be determined to increase substantially the supply of organs for transplantation. We justify this approach by identifying certain flaws in the Uniform Determination of Death Act and proposing a modification of that law that permits earlier procurement of healthier organs in greater numbers.</p>","PeriodicalId":47377,"journal":{"name":"Journal of Medicine and Philosophy","volume":" ","pages":"458-469"},"PeriodicalIF":1.3,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cognitive Enhancement, Hyperagency, and Responsibility Explosion. 认知增强、超代理和责任爆炸。
IF 1.3 3区 哲学 Q3 ETHICS Pub Date : 2024-09-03 DOI: 10.1093/jmp/jhae025
Emma C Gordon

Hyperagency objections appeal to the risk that cognitive enhancement may negatively impact our well-being by giving us too much control. I charitably formulate and engage with a prominent version of this objection due to Sandel (2009) -viz., that cognitive enhancement may negatively impact our well-being by creating an "explosion" of responsibilities. I first outline why this worry might look prima facie persuasive, and then I show that it can ultimately be defended against. At the end of the day, if we are to resist cognitive enhancement, it should not be based on a Sandel-style hyperagency argument.

超代理的反对意见认为,认知能力的提升可能会给我们带来过多的控制权,从而对我们的福祉产生负面影响。我善意地提出并参与了桑德尔(2009)提出的这一反对意见的一个重要版本--即认知能力的提升可能会因造成责任的 "爆炸 "而对我们的福祉产生负面影响。我首先概述了为什么这种担忧表面上看起来很有说服力,然后说明它最终是可以抵御的。归根结底,如果我们要抵制认知增强,就不应该基于桑德尔式的超代理论证。
{"title":"Cognitive Enhancement, Hyperagency, and Responsibility Explosion.","authors":"Emma C Gordon","doi":"10.1093/jmp/jhae025","DOIUrl":"10.1093/jmp/jhae025","url":null,"abstract":"<p><p>Hyperagency objections appeal to the risk that cognitive enhancement may negatively impact our well-being by giving us too much control. I charitably formulate and engage with a prominent version of this objection due to Sandel (2009) -viz., that cognitive enhancement may negatively impact our well-being by creating an \"explosion\" of responsibilities. I first outline why this worry might look prima facie persuasive, and then I show that it can ultimately be defended against. At the end of the day, if we are to resist cognitive enhancement, it should not be based on a Sandel-style hyperagency argument.</p>","PeriodicalId":47377,"journal":{"name":"Journal of Medicine and Philosophy","volume":" ","pages":"488-498"},"PeriodicalIF":1.3,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11369811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141447319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do Not Risk Homicide: Abortion After 10 Weeks Gestation. 不要冒险杀人:怀孕 10 周后堕胎。
IF 1.3 3区 哲学 Q3 ETHICS Pub Date : 2024-07-11 DOI: 10.1093/jmp/jhae018
Matthew Braddock

When an abortion is performed, someone dies. Are we killing a human person? Widespread disagreement exists. However, it is not necessary to establish personhood in order to establish the wrongness of abortion: a substantial chance of personhood is enough. We defend The Do Not Risk Homicide Argument: abortions are wrong after 10 weeks gestation because they substantially and unjustifiably risk homicide, the unjust killing of a human person. Why 10 weeks? Because the cumulative evidence establishes a substantial chance (a more than one in five chance) that preborn human beings are persons after 10 weeks (if not before then). We submit evidence from our bad track record, widespread disagreement about personhood (after 10 weeks gestation), problems with theories of personhood, the similarity between preborn human beings and premature newborns, miscalculations of gestational age, and the common intuitive responses of women to their pregnancies and miscarriages. Our argument is cogent because it bypasses the stalemate over preborn personhood and rests on common ground rather than contentious metaphysics. It also strongly suggests that society must do more to protect preborn human beings. We briefly discuss its practical implications for fetal pain relief, social policy, and abortion law.

堕胎就意味着有人死亡。我们是在杀人吗?存在着广泛的分歧。然而,要确定堕胎的错误性,并不一定要确定人的身份:只要有相当大的机会确定人的身份就足够了。我们为 "不冒杀人风险论证 "辩护:妊娠 10 周后的堕胎是错误的,因为堕胎实质上无理地冒着杀人的风险,即不公正地杀害一个人。为什么是 10 周?因为累积的证据证明,10 周后(如果不是在 10 周前)胎儿成为人的几率很大(超过五分之一的几率)。我们提交的证据包括:我们的不良记录、关于人格(妊娠 10 周后)的广泛分歧、人格理论的问题、早产儿与早产新生儿的相似性、胎龄计算错误以及妇女对怀孕和流产的常见直觉反应。我们的论点是有说服力的,因为它绕过了在先出生者的人格问题上的僵局,建立在共同的基础上,而不是建立在有争议的形而上学上。它还有力地表明,社会必须采取更多措施来保护早产儿。我们简要讨论了它对胎儿镇痛、社会政策和堕胎法的实际影响。
{"title":"Do Not Risk Homicide: Abortion After 10 Weeks Gestation.","authors":"Matthew Braddock","doi":"10.1093/jmp/jhae018","DOIUrl":"10.1093/jmp/jhae018","url":null,"abstract":"<p><p>When an abortion is performed, someone dies. Are we killing a human person? Widespread disagreement exists. However, it is not necessary to establish personhood in order to establish the wrongness of abortion: a substantial chance of personhood is enough. We defend The Do Not Risk Homicide Argument: abortions are wrong after 10 weeks gestation because they substantially and unjustifiably risk homicide, the unjust killing of a human person. Why 10 weeks? Because the cumulative evidence establishes a substantial chance (a more than one in five chance) that preborn human beings are persons after 10 weeks (if not before then). We submit evidence from our bad track record, widespread disagreement about personhood (after 10 weeks gestation), problems with theories of personhood, the similarity between preborn human beings and premature newborns, miscalculations of gestational age, and the common intuitive responses of women to their pregnancies and miscarriages. Our argument is cogent because it bypasses the stalemate over preborn personhood and rests on common ground rather than contentious metaphysics. It also strongly suggests that society must do more to protect preborn human beings. We briefly discuss its practical implications for fetal pain relief, social policy, and abortion law.</p>","PeriodicalId":47377,"journal":{"name":"Journal of Medicine and Philosophy","volume":" ","pages":"414-432"},"PeriodicalIF":1.3,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140904913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What Happens When the Zygote Divides? On the Metaphysics of Monozygotic Twinning. 当胎儿分裂时会发生什么?论单卵双生的形而上学。
IF 1.3 3区 哲学 Q3 ETHICS Pub Date : 2024-07-11 DOI: 10.1093/jmp/jhae022
Jeremy W Skrzypek

It is often argued that certain metaphysical complications surrounding the phenomenon of monozygotic twinning force us to conclude that, prior to the point at which twinning is no longer possible, the zygote or early embryo cannot be considered an individual human organism. In this essay, I argue, on the contrary, that there are in fact several ways of making sense of monozygotic twinning that uphold the humanity of the original zygote, but also that there is no easy answer to what happens when the human zygote twins. All of the options available carry with them one or more surprising, alarming, or otherwise counterintuitive implications. All things considered, I conclude that the "budding option," according to which the original human organism present before twinning carries on as one of the resulting embryos but not the other, is the most plausible explanation of what happens when a human zygote twins.

经常有人认为,围绕单卵孪生现象的某些形而上学复杂性迫使我们得出结论,即在孪生不再可能发生之前,不能将合子或早期胚胎视为一个独立的人类有机体。在这篇文章中,我的论点恰恰相反,事实上,有几种方法可以解释单卵孪生,从而维护原始合子的人性,但同时,对于人类合子孪生时会发生什么,也没有简单的答案。所有可供选择的方案都有一个或多个令人惊讶、令人震惊或违背直觉的含义。考虑到所有因素,我的结论是 "萌芽方案",根据该方案,孪生前的原始人类有机体将作为其中一个胚胎而不是另一个胚胎继续存在,这是对人类合子孪生时发生的情况最合理的解释。
{"title":"What Happens When the Zygote Divides? On the Metaphysics of Monozygotic Twinning.","authors":"Jeremy W Skrzypek","doi":"10.1093/jmp/jhae022","DOIUrl":"10.1093/jmp/jhae022","url":null,"abstract":"<p><p>It is often argued that certain metaphysical complications surrounding the phenomenon of monozygotic twinning force us to conclude that, prior to the point at which twinning is no longer possible, the zygote or early embryo cannot be considered an individual human organism. In this essay, I argue, on the contrary, that there are in fact several ways of making sense of monozygotic twinning that uphold the humanity of the original zygote, but also that there is no easy answer to what happens when the human zygote twins. All of the options available carry with them one or more surprising, alarming, or otherwise counterintuitive implications. All things considered, I conclude that the \"budding option,\" according to which the original human organism present before twinning carries on as one of the resulting embryos but not the other, is the most plausible explanation of what happens when a human zygote twins.</p>","PeriodicalId":47377,"journal":{"name":"Journal of Medicine and Philosophy","volume":" ","pages":"336-353"},"PeriodicalIF":1.3,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wakefield's Harm-Based Critique of the Biostatistical Theory. 韦克菲尔德对生物统计理论的基于伤害的批判。
IF 1.3 3区 哲学 Q3 ETHICS Pub Date : 2024-07-11 DOI: 10.1093/jmp/jhae017
Christopher Boorse

Jerome Wakefield criticizes my biostatistical analysis of the pathological-as statistically subnormal biological part-functional ability relative to species, sex, and age-for its lack of a harm clause. He first charges me with ignoring two general distinctions: biological versus medical pathology, and disease of a part versus disease of a whole organism. He then offers 10 counterexamples that, he says, are harmless dysfunctions but not medical disorders. Wakefield ends by arguing that we need a harm clause to explain American psychiatry's 1973 decision to declassify homosexuality. I reply, first, that his two distinctions are philosophic fantasies alien to medical usage, invented only to save his own harmful-dysfunction analysis (HDA) from a host of obvious counterexamples. In any case, they do not coincide with the harmless/harmful distinction. In reality, medicine admits countless chronic diseases that are, contrary to Wakefield, subclinical for most of their course, as well as many kinds of typically harmless skin pathology. As for his 10 counterexamples, no medical source he cites describes them as he does. I argue that none of his examples contradicts the biostatistical analysis: all either are not part-dysfunctions (situs inversus, incompetent sperm, normal-flora infection) or are indeed classified as medical disorders (donated kidney, Typhoid Mary's carrier status, latent tuberculosis or HIV, cherry angiomas). And if Wakefield's HDA fits psychiatry, the fact that it does not fit medicine casts doubt on psychiatry's status as a medical specialty.

杰罗姆-韦克菲尔德批评我对病理学的生物统计分析,认为病理学是相对于物种、性别和年龄而言的统计上不正常的生物部分功能能力,因为它缺乏危害条款。他首先指责我忽略了两个一般区别:生物病理学与医学病理学的区别,以及部分疾病与整个机体疾病的区别。然后,他提出了 10 个反例,他说这些反例都是无害的功能障碍,但不是医学疾病。最后,韦克菲尔德认为我们需要一个危害条款来解释美国精神病学在1973年做出的将同性恋解密的决定。我的回答是,首先,他的这两种区分是与医学用途格格不入的哲学幻想,只是为了让他自己的有害功能障碍分析法(HDA)免于一系列显而易见的反例而发明的。无论如何,它们与无害/有害的区别并不一致。在现实中,医学承认有无数的慢性疾病,与韦克菲尔德的观点相反,这些疾病在大部分病程中都是亚临床的,还有许多种典型的无害皮肤病变。至于他的 10 个反例,他引用的任何医学资料都没有像他那样进行描述。我认为,他的例子没有一个与生物统计分析相矛盾:所有的例子要么不是部分功能障碍(坐位不全、无精子、正常菌群感染),要么确实被归类为医学疾病(捐赠肾脏、伤寒玛丽携带者身份、潜伏肺结核或艾滋病毒、樱桃状血管瘤)。如果韋克菲爾德的HDA適用於精神病學,那麼它不適用於醫學的事實就會讓人懷疑精神病學作為醫學專科的地位。
{"title":"Wakefield's Harm-Based Critique of the Biostatistical Theory.","authors":"Christopher Boorse","doi":"10.1093/jmp/jhae017","DOIUrl":"10.1093/jmp/jhae017","url":null,"abstract":"<p><p>Jerome Wakefield criticizes my biostatistical analysis of the pathological-as statistically subnormal biological part-functional ability relative to species, sex, and age-for its lack of a harm clause. He first charges me with ignoring two general distinctions: biological versus medical pathology, and disease of a part versus disease of a whole organism. He then offers 10 counterexamples that, he says, are harmless dysfunctions but not medical disorders. Wakefield ends by arguing that we need a harm clause to explain American psychiatry's 1973 decision to declassify homosexuality. I reply, first, that his two distinctions are philosophic fantasies alien to medical usage, invented only to save his own harmful-dysfunction analysis (HDA) from a host of obvious counterexamples. In any case, they do not coincide with the harmless/harmful distinction. In reality, medicine admits countless chronic diseases that are, contrary to Wakefield, subclinical for most of their course, as well as many kinds of typically harmless skin pathology. As for his 10 counterexamples, no medical source he cites describes them as he does. I argue that none of his examples contradicts the biostatistical analysis: all either are not part-dysfunctions (situs inversus, incompetent sperm, normal-flora infection) or are indeed classified as medical disorders (donated kidney, Typhoid Mary's carrier status, latent tuberculosis or HIV, cherry angiomas). And if Wakefield's HDA fits psychiatry, the fact that it does not fit medicine casts doubt on psychiatry's status as a medical specialty.</p>","PeriodicalId":47377,"journal":{"name":"Journal of Medicine and Philosophy","volume":" ","pages":"367-388"},"PeriodicalIF":1.3,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethical Problems of Observational Studies and Big Data Compared to Randomized Trials. 观察研究和大数据与随机试验相比存在的伦理问题。
IF 1.3 3区 哲学 Q3 ETHICS Pub Date : 2024-07-11 DOI: 10.1093/jmp/jhae021
Jean Raymond, Robert Fahed, Tim E Darsaut

The temptation to use prospective observational studies (POS) instead of conducting difficult trials (RCTs) has always existed, but with the advent of powerful computers and large databases, it can become almost irresistible. We examine the potential consequences, were this to occur, by comparing two hypothetical studies of a new treatment: one RCT, and one POS. The POS inevitably submits more patients to inferior research methodology. In RCTs, patients are clearly informed of the research context, and 1:1 randomized allocation between experimental and validated treatment balances risks for each patient. In POS, for each patient, the risks of receiving inferior treatment are impossible to estimate. The research context and the uncertainty are down-played, and patients and clinicians are at risk of becoming passive research subjects in studies performed from an outsider's view, which potentially has extraneous objectives, and is conducted without their explicit, autonomous, and voluntary involvement and consent.

使用前瞻性观察研究(POS)而不是进行困难试验(RCT)的诱惑一直存在,但随着功能强大的计算机和大型数据库的出现,这种诱惑几乎变得不可抗拒。我们通过比较两种假定的新疗法研究:一种是 RCT,另一种是 POS,来探讨一旦出现这种情况的潜在后果。POS 不可避免地会让更多患者接受低劣的研究方法。在研究性临床试验中,患者会被明确告知研究背景,并在实验治疗和验证治疗之间进行 1:1 随机分配,以平衡每位患者的风险。而在 POS 中,每个病人接受劣质治疗的风险是无法估计的。研究背景和不确定性被淡化,患者和临床医生有可能成为被动的研究对象,从局外人的角度进行研究,这可能具有无关的目的,并且是在没有他们明确、自主、自愿参与和同意的情况下进行的。
{"title":"Ethical Problems of Observational Studies and Big Data Compared to Randomized Trials.","authors":"Jean Raymond, Robert Fahed, Tim E Darsaut","doi":"10.1093/jmp/jhae021","DOIUrl":"10.1093/jmp/jhae021","url":null,"abstract":"<p><p>The temptation to use prospective observational studies (POS) instead of conducting difficult trials (RCTs) has always existed, but with the advent of powerful computers and large databases, it can become almost irresistible. We examine the potential consequences, were this to occur, by comparing two hypothetical studies of a new treatment: one RCT, and one POS. The POS inevitably submits more patients to inferior research methodology. In RCTs, patients are clearly informed of the research context, and 1:1 randomized allocation between experimental and validated treatment balances risks for each patient. In POS, for each patient, the risks of receiving inferior treatment are impossible to estimate. The research context and the uncertainty are down-played, and patients and clinicians are at risk of becoming passive research subjects in studies performed from an outsider's view, which potentially has extraneous objectives, and is conducted without their explicit, autonomous, and voluntary involvement and consent.</p>","PeriodicalId":47377,"journal":{"name":"Journal of Medicine and Philosophy","volume":" ","pages":"389-398"},"PeriodicalIF":1.3,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Medicine and Philosophy
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1