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Uncertainty, Evidence, and the Integration of Machine Learning into Medical Practice. 不确定性、证据和机器学习与医疗实践的整合。
IF 1.6 3区 哲学 Q2 Medicine Pub Date : 2023-02-17 DOI: 10.1093/jmp/jhac034
Thomas Grote, Philipp Berens

In light of recent advances in machine learning for medical applications, the automation of medical diagnostics is imminent. That said, before machine learning algorithms find their way into clinical practice, various problems at the epistemic level need to be overcome. In this paper, we discuss different sources of uncertainty arising for clinicians trying to evaluate the trustworthiness of algorithmic evidence when making diagnostic judgments. Thereby, we examine many of the limitations of current machine learning algorithms (with deep learning in particular) and highlight their relevance for medical diagnostics. Among the problems we inspect are the theoretical foundations of deep learning (which are not yet adequately understood), the opacity of algorithmic decisions, and the vulnerabilities of machine learning models, as well as concerns regarding the quality of medical data used to train the models. Building on this, we discuss different desiderata for an uncertainty amelioration strategy that ensures that the integration of machine learning into clinical settings proves to be medically beneficial in a meaningful way.

鉴于机器学习在医疗应用方面的最新进展,医疗诊断的自动化迫在眉睫。也就是说,在机器学习算法进入临床实践之前,需要克服认知层面的各种问题。在本文中,我们讨论了临床医生在做出诊断判断时试图评估算法证据的可信度时产生的不同不确定性来源。因此,我们研究了当前机器学习算法(特别是深度学习)的许多局限性,并强调了它们与医学诊断的相关性。我们考察的问题包括深度学习的理论基础(尚未得到充分理解)、算法决策的不透明性、机器学习模型的脆弱性,以及对用于训练模型的医疗数据质量的担忧。在此基础上,我们讨论了不确定性改善策略的不同需求,以确保将机器学习整合到临床环境中以有意义的方式证明在医学上有益。
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引用次数: 7
Recognizing the Diverse Faces of Later Life: Old Age as a Category of Intersectional Analysis in Medical Ethics. 认识到晚年生活的不同面貌:老年作为医学伦理学交叉分析的一个范畴。
IF 1.6 3区 哲学 Q2 Medicine Pub Date : 2023-02-17 DOI: 10.1093/jmp/jhac038
Merle Weßel, Mark Schweda

Public and academic medical ethics debates surrounding justice and age discrimination often proceed from a problematic understanding of old age that ignores the diversity of older people. This article introduces the feminist perspective of intersectionality to medical ethical debates on aging and old age in order to analyze the structural discrimination of older people in medicine and health care. While current intersectional approaches in this field focus on race, gender, and sexuality, we thus set out to introduce aging and old age as an additional category that is becoming more relevant in the context of longer life expectancies and increasing population aging. We analyze three exemplary cases on the individual, institutional, and public health level, and argue that considering the intersections of old age with other social categories helps to accommodate the diverse identities of older people and detect inequality and structural discrimination.

围绕正义和年龄歧视的公共和学术医学伦理辩论往往源于对老年的一种有问题的理解,这种理解忽视了老年人的多样性。本文将交叉性的女性主义视角引入到关于老龄化和老年的医学伦理争论中,以分析老年人在医学和卫生保健中的结构性歧视。虽然目前这一领域的交叉方法主要关注种族、性别和性取向,但我们因此开始引入老龄化和老年作为一个额外的类别,在预期寿命延长和人口老龄化加剧的背景下,这一类别正变得越来越重要。我们在个人、机构和公共卫生层面分析了三个典型案例,并认为考虑老年与其他社会类别的交叉点有助于适应老年人的不同身份,并发现不平等和结构性歧视。
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引用次数: 4
The Fraught Notion of a "Good Death" in Pediatrics. 儿科中令人担忧的“善终”概念。
IF 1.6 3区 哲学 Q2 Medicine Pub Date : 2023-02-17 DOI: 10.1093/jmp/jhac036
Bryanna Moore

In this article, I sort through some of the confusion surrounding what constitutes the controversial notion of a "good death" for children. I distinguish, first, between metaphysical and practical disagreements about the notion of a good death, and, second, between accounts of a good death that minimally and maximally promote the dying child's interests. I propose a narrowed account of the dying child's interests, because they differ from the interests of non-dying children. Importantly, this account illustrates how disagreements at the end of a child's life are sometimes the result of a shift from a future to a present-oriented understanding of the child's interests on the part of some stakeholders but not others, and sometimes the result of a values-based disagreement about how different interests should be weighted. This brings into sharper focus the questions of for whom, and in what way, a child's death might be considered good.

在这篇文章中,我整理了一些关于什么构成了孩子“善终”这个有争议的概念的困惑。首先,我区分了对善死概念的形而上学和实践上的分歧,其次,区分了对善死的描述,最大限度地促进了垂死孩子的利益。我建议缩小垂死儿童的利益范围,因为它们不同于非垂死儿童的利益。重要的是,这一描述说明了在孩子生命结束时的分歧有时是一些利益相关者对孩子利益的理解从未来转向现在的结果,而不是其他利益相关者的结果,有时是基于价值观的分歧的结果,即不同的利益应该如何加权。这让一个问题变得更加尖锐:一个孩子的死亡对谁、以何种方式被认为是好事。
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引用次数: 2
Critically Appraising Pragmatist Critiques of Evidence-Based Medicine: Is EBM Defensible on Pragmatist Grounds? 批判评价实用主义对循证医学的批评:循证医学在实用主义基础上站得住脚吗?
IF 1.6 3区 哲学 Q2 Medicine Pub Date : 2023-02-17 DOI: 10.1093/jmp/jhac037
S Joshua Thomas

Significant contributions to debates in the philosophy of evidence-based medicine (EBM) have come from a variety of different philosophical quarters, yet mainstream discourse in the field has been largely devoid of contributions from scholars working in the pragmatist tradition. This is a particularly conspicuous omission, given pragmatism's commitment to the melioristic view that philosophy both can, and should, be about the business of concretely bettering the human estate. Two exceptions to this oversight come from Brian Walsh and Maya Goldenberg. Unfortunately, in both cases, the misapplication of pragmatist thinking leads to the mistaken view that EBM is committed to some form of pernicious objectivism. This article aims to revise these pragmatist critiques in order to bring them more consistently in line with pragmatist values and commitments. Doing so shows that EBM is defensible on pragmatist grounds against objectivist attacks.

对循证医学(EBM)哲学辩论的重大贡献来自各种不同的哲学领域,但该领域的主流话语在很大程度上缺乏实用主义传统学者的贡献。这是一个特别明显的遗漏,因为实用主义对改良主义观点的承诺是,哲学既可以,也应该是具体改善人类财产的事业。这一疏忽的两个例外来自布莱恩·沃尔什和玛雅·戈登伯格。不幸的是,在这两种情况下,对实用主义思维的误用导致了一种错误的观点,即循证医学致力于某种形式的有害客观主义。本文旨在修改这些实用主义的批评,以使它们更一致地符合实用主义的价值观和承诺。这样做表明,循证医学在实用主义的基础上是可以抵御客观主义攻击的。
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引用次数: 1
Alzheimer's, Advance Directives, and Interpretive Authority. 阿尔茨海默氏症,预先指示和解释权。
IF 1.6 3区 哲学 Q2 Medicine Pub Date : 2023-02-17 DOI: 10.1093/jmp/jhac032
Charles L Barzun

Philosophers have debated whether the advance directives of Alzheimer's patients should be enforced, even if patients seem content in their demented state. The debate raises deep questions about the nature of human autonomy and personal identity. But it tends to proceed on the assumption that the advance directive's terms are clear, whereas in practice they are often vague or ambiguous, requiring the patient's healthcare proxy to make difficult judgment calls. This practical wrinkle raises its own, distinct but related, philosophical question: what criteria may the proxy bring to bear when making such interpretive judgments on which the patient's life may depend? After defending a general policy of enforcing advance directives on normative (rather than metaphysical) grounds, I argue that when advance directives are vague, a patient's proxy may permissibly make her own fresh evaluation of the patient's life as a whole and, in so doing, consider how the patient's character as a demented person contributes or fails to contribute to that life.

哲学家们一直在争论是否应该执行老年痴呆症患者的预先指示,即使患者似乎对自己的精神错乱状态感到满意。这场辩论提出了关于人类自主和个人身份本质的深刻问题。但它倾向于假设预先指示的条款是明确的,而在实践中,它们往往是模糊或模棱两可的,要求病人的医疗代理做出艰难的判断。这个实际的问题提出了它自己的,独特但相关的哲学问题:当代理人做出这样的解释性判断时,病人的生命可能取决于什么标准?在为在规范(而不是形而上学)的基础上执行预先指示的一般政策辩护之后,我认为,当预先指示含糊不清时,患者的代理人可以允许自己对患者的整体生活进行新的评估,并在这样做时,考虑患者作为精神错乱患者的性格如何对其生活做出贡献或未能做出贡献。
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引用次数: 1
Philosophical Failure and the Reasonability View of Conscientious Objection: Can Reason Adjudicate Metaphysical or Religious Claims? 哲学失败与良心拒服兵役的合理性观点:理性能裁决形而上学或宗教主张吗?
IF 1.6 3区 哲学 Q2 Medicine Pub Date : 2023-02-17 DOI: 10.1093/jmp/jhac033
Abram L Brummett

Robert Card has proposed a reasonability view of conscientious objection that asks providers to state the reasons for their objection for evaluation and approval by a review board. Jason Marsh has challenged Card to provide explicit criteria for what makes a conscientious objection reasonable, which he claims will be too difficult a task given that such objections often involve contentious metaphysical or religious claims. Card has responded by outlining standards by which a conscientious objection could be judged reasonable. In this paper, I extend Marsh's critique to key concepts in the standards outlined by Card such as abortifacient, harm, emergency, and discrimination, showing they can be given radically different interpretations given different metaphysical or religious presumptions. To resolve these conflicting interpretations, a reasonability view of conscientious objection will need more than the criteria outlined by Card, it will need the resources to evaluate the reasonability of metaphysical or religious claims.

罗伯特·卡德提出了良心反对的合理性观点,要求提供者陈述他们反对的理由,以供审查委员会评估和批准。杰森·马什向卡德提出了挑战,要求他提供明确的标准来说明什么是合理的良心反对,他声称,鉴于这种反对往往涉及有争议的形而上学或宗教主张,这将是一项艰巨的任务。卡德对此作出了回应,他列出了判断良心反对是否合理的标准。在本文中,我将Marsh的批判扩展到卡德概述的标准中的关键概念,如堕胎、伤害、紧急情况和歧视,表明它们可以根据不同的形而上学或宗教假设得到完全不同的解释。为了解决这些相互矛盾的解释,良心反对的合理性观点需要的不仅仅是卡德概述的标准,它还需要评估形而上学或宗教主张的合理性的资源。
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引用次数: 1
Patient Safety and the Question of Dignitary Harms. 患者安全与尊严伤害问题。
IF 1.6 3区 哲学 Q2 Medicine Pub Date : 2023-02-17 DOI: 10.1093/jmp/jhac035
Polly Mitchell, Alan Cribb, Vikki Entwistle

Patient safety is a central aspect of healthcare quality, focusing on preventable, iatrogenic harm. Harm, in this context, is typically assumed to mean physical injury to patients, often caused by technical error. However, some contributions to the patient safety literature have argued that disrespectful behavior towards patients can cause harm, even when it does not lead to physical injury. This paper investigates the nature of such dignitary harms and explores whether they should be included within the scope of patient safety as a field of practice. We argue that dignitary harms in health care are-at least sometimes-preventable, iatrogenic harms. While we caution against including dignitary harms within the scope of patient safety just because they are relevantly similar to other iatrogenic harms, we suggest that thinking about dignitary harms can help to elucidate the value of patient safety, and to illuminate the evolving relationship between safety and quality.

患者安全是医疗质量的一个核心方面,重点关注可预防的先天性伤害。在这种情况下,伤害通常被认为是指对患者造成的身体伤害,通常是由技术错误造成的。然而,一些有关患者安全的文献认为,对患者的不尊重行为即使不会导致身体伤害,也会造成伤害。本文研究了此类尊严伤害的性质,并探讨了是否应将其纳入患者安全这一实践领域的范畴。我们认为,医疗保健中的尊严伤害--至少有时--是可预防的、先天性的伤害。虽然我们告诫不要因为尊严伤害与其他先天性伤害相似就将其纳入患者安全的范畴,但我们认为对尊严伤害的思考有助于阐明患者安全的价值,并阐明安全与质量之间不断发展的关系。
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引用次数: 0
Can a MacIntyrian Care about Severely Disabled Strangers? 麦金蒂尔人能关心严重残疾的陌生人吗?
IF 1.6 3区 哲学 Q2 Medicine Pub Date : 2022-12-23 DOI: 10.1093/jmp/jhac029
Gennady McCracken

I argue that Alasdair MacIntyre has important resources to provide in the debate over the moral status of severely disabled people. In contrast, Gregory Poore suggests that MacIntyre's virtue theory cannot account for our responsibilities to severely disabled people. Given that MacIntyre bases his theory around community membership, this charge is made especially severe in the case of severely disabled strangers. I present an interpretation of MacIntyre that accounts for responsibilities to severely disabled strangers. I then argue that Poore is wrong to conclude that MacIntyre does not include severely disabled people in communities.

我认为Alasdair MacIntyre在关于严重残疾人的道德地位的辩论中可以提供重要的资源。相反,格雷戈里·普尔认为麦金太尔的美德理论不能解释我们对严重残疾人的责任。考虑到麦金泰尔的理论是建立在社区成员的基础上的,这种指控在严重残疾的陌生人身上显得尤为严重。我对麦金太尔的解释说明了对严重残疾的陌生人的责任。然后,我认为普尔认为麦金太尔不包括社区中严重残疾人的结论是错误的。
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引用次数: 0
Is Aging a Disease? The Theoretical Definition of Aging in the Light of the Philosophy of Medicine. 衰老是一种疾病吗?医学哲学视野下衰老的理论定义。
IF 1.6 3区 哲学 Q2 Medicine Pub Date : 2022-12-23 DOI: 10.1093/jmp/jhac030
Cristian Saborido, Pablo García-Barranquero

In the philosophical debate on aging, it is common to raise the question of the theoretical definition of aging in terms of its possible characterization as a disease. Understanding aging as a disease seems to imply its medicalization, which has important practical consequences. In this paper, we analyze the question of whether aging is a disease by appealing to the concept of disease in the philosophy of medicine. As a result of this analysis, we argue that a pragmatist approach to the conception of disease is the best alternative to highlight the relevance of the medicalization of aging. From this pragmatist perspective, it can be seen that the notion of aging is going through a conceptual change, and aging can today be understood as a not radically different process from any other condition that is usually considered a disease.

在关于衰老的哲学辩论中,通常会提出衰老的理论定义问题,因为它可能被描述为一种疾病。将衰老理解为一种疾病似乎意味着将其医学化,这具有重要的实际意义。本文借助医学哲学中的疾病概念来分析衰老是否为疾病的问题。作为这一分析的结果,我们认为,一个实用主义的方法,以疾病的概念是最好的选择,以突出老化的医学化的相关性。从实用主义的角度来看,衰老的概念正在经历一种观念上的变化,今天的衰老可以被理解为与通常被认为是疾病的任何其他状况没有根本不同的过程。
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引用次数: 3
The Desirability of Difference: Georges Canguilhem and Body Integrity Identity Disorder. 差异的可取性:康圭朗与身体完整性认同障碍。
IF 1.6 3区 哲学 Q2 Medicine Pub Date : 2022-12-23 DOI: 10.1093/jmp/jhac027
Richard B Gibson

Opponents of the provision of therapeutic, healthy limb amputation in Body Integrity Identity Disorder cases argue that such surgeries stand in contrast to the goal of medical practice - that of health restoration and maintenance. This paper refutes such a conclusion via an appeal to the nuanced and reflective model of health proposed by Georges Canguilhem. The paper examines the conceptual entanglement of the statistically common with the normatively desirable, arguing that a healthy body can take multiple forms, including that of an amputee, provided that such a form enables the continuing ability to initiate new norms of existence. It concludes that the practice of healthy limb amputation in cases of Body Integrity Identity Disorder is not only compatible with the goal of medicine but is potentially the only method of achieving this goal in the face of a complex and often mischaracterized disorder.

反对在身体完整性认同障碍病例中提供治疗性、健康的肢体截肢的人认为,这种手术与医疗实践的目标——恢复和维持健康——背道而驰。本文通过对乔治·康圭朗提出的细致入微和反思的健康模型的呼吁,反驳了这样的结论。本文考察了统计学上的共性与规范上的理想之间的概念纠缠,认为一个健康的身体可以有多种形式,包括截肢者的身体,只要这种形式能够持续地启动新的存在规范。它的结论是,在身体完整性认同障碍的情况下,健康截肢的做法不仅符合医学目标,而且可能是在面对复杂且经常被误解的疾病时实现这一目标的唯一方法。
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引用次数: 1
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Journal of Medicine and Philosophy
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