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Amplatzer vascular plug use for the treatment of pulmonary arteriovenous malformation. Amplatzer血管塞用于治疗肺动静脉畸形。
IF 1.2 Q4 RESPIRATORY SYSTEM Pub Date : 2025-11-01 Epub Date: 2025-10-24 DOI: 10.4103/lungindia.lungindia_381_25
Rodrigo M da Silva, Glaucia Zanetti, Edson Marchiori
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引用次数: 0
Breaking through the oxygen ceiling: Evidence-based strategies for conquering refractory hypoxemia. 突破氧气上限:克服难治性低氧血症的循证策略。
IF 1.2 Q4 RESPIRATORY SYSTEM Pub Date : 2025-11-01 Epub Date: 2025-10-24 DOI: 10.4103/lungindia.lungindia_139_25
Shibu Sasidharan, Sunali Nanayakkara, Ritu Grewal, Priyank Dhiman
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引用次数: 0
Pneumothorax in Kashmir valley: A comprehensive study. 克什米尔山谷的气胸:一项综合研究。
IF 1.2 Q4 RESPIRATORY SYSTEM Pub Date : 2025-11-01 Epub Date: 2025-10-24 DOI: 10.4103/lungindia.lungindia_87_25
Shahbaz Bashir, Aqib Amin, Abid Kangoo, Yawar Nazir, Sheikh Mudassir Khurshid, Naiem Ahrar, Hakeem Zubair Ashraf, Farooq A Ganie

Background and objective: Pneumothorax presents the significant clinical and public health challenge in the Kashmir region due to the unique geographical, demographic, and socioeconomic factors. This study analyses the clinical patterns, etiological factors, management strategies, and outcomes of 650 pneumothorax cases treated at a tertiary care centre in Kashmir. This study aims to evaluate the clinical patterns, etiological factors, diagnostic approaches, management strategies, and outcomes of pneumothorax cases in the Kashmir region. By analysing a large dataset from a tertiary care centre, the study seeks to highlight region-specific challenges and propose improvements in diagnostic and therapeutic strategies to enhance patient care.

Materials and methods: An ambispective analysis of 650 cases of pneumothorax from January 2020 to July 2024 was conducted. Patients were classified as having traumatic, spontaneous, or iatrogenic pneumothorax. Data on demographic distribution, clinical presentation, associated injuries, management approaches, complications and outcomes were analysed using descriptive statistics.

Results: Traumatic pneumothorax was the most common type (61.5%, n = 400), with unilateral presentation in 67.5% of cases. Spontaneous pneumothorax accounted for 21.5% (n = 140), of which secondary causes predominated (54.3%). Iatrogenic pneumothorax comprised 16.9% (n = 110). Chest radiography (CxR) was the primary diagnostic tool (100%), with CT scanning required in 28.5% of cases. Ultrasound showed 89.2% sensitivity in emergency settings. Intercostal tube drainage (ICTD) was the mainstay of treatment in 78.5% of cases, yielding a success rate of 94.5%. Complications included persistent air leak (12%), empyema (3.7%), and recurrence (6.3%).

Conclusion: Our study provides a comprehensive analysis of pneumothorax in the Kashmir region, highlighting its unique etiological and clinical patterns. The findings emphasize the need for improved trauma care systems, standardized treatment protocols, and widespread training in emergency procedures, particularly in rural and resource-limited settings, to optimize patient outcomes and reduce complications.

背景和目的:由于独特的地理、人口和社会经济因素,气胸在克什米尔地区提出了重大的临床和公共卫生挑战。本研究分析了在克什米尔三级保健中心治疗的650例气胸病例的临床模式、病因、管理策略和结果。本研究旨在评估克什米尔地区气胸病例的临床模式、病因、诊断方法、管理策略和结果。通过分析来自三级医疗中心的大型数据集,该研究旨在突出区域特有的挑战,并提出改进诊断和治疗策略,以加强患者护理。材料与方法:对2020年1月至2024年7月收治的650例气胸患者进行回顾性分析。患者分为外伤性气胸、自发性气胸和医源性气胸。使用描述性统计分析人口统计学分布、临床表现、相关损伤、管理方法、并发症和结果的数据。结果:外伤性气胸是最常见的类型(61.5%,n = 400),单侧表现占67.5%。自发性气胸占21.5% (n = 140),其中继发性原因占54.3%。医源性气胸占16.9% (n = 110)。胸部x线摄影(CxR)是主要诊断工具(100%),28.5%的病例需要CT扫描。超声在紧急情况下的敏感性为89.2%。78.5%的病例以肋间管引流(ICTD)为主,成功率为94.5%。并发症包括持续漏气(12%)、脓胸(3.7%)和复发(6.3%)。结论:我们的研究提供了克什米尔地区气胸的全面分析,突出了其独特的病因和临床模式。研究结果强调需要改进创伤护理系统、标准化治疗方案和广泛的急救程序培训,特别是在农村和资源有限的环境中,以优化患者预后并减少并发症。
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引用次数: 0
Walking a tightrope - A multitude of airway challenges in a mediastinal mass excision. 走钢丝-纵隔肿块切除术中气道的诸多挑战。
IF 1.2 Q4 RESPIRATORY SYSTEM Pub Date : 2025-11-01 Epub Date: 2025-10-24 DOI: 10.4103/lungindia.lungindia_114_25
S Gajalakshmi, Shreya B Shah, Vishesh Jain, Jidin Joy

Providing a satisfactory lung isolation during the video-assisted thoracoscopic surgery in infants can be challenging due to the limited options for one lung ventilation. Additional anatomic pathologies/derangements add to the complexity in managing the airway in these tiny infants. We discuss a case of a 10-month infant scheduled for video-assisted excision of a recurrent bronchogenic cyst that was in proximity to recurrent laryngeal nerves, compressing the trachea and bronchus. The associated severe tracheo-bronchomalacia and the risk of an inadvertent recurrent laryngeal nerve injury demanded a need to exercise caution and necessitated a personalised approach to aid surgery. This article aims to outline the several airway challenges encountered intraoperatively in this infant and thereby contribute to the literature on the management of such cases. While it is imperative to tailor the management strategies to individual case, we endeavour to navigate the intricate complexities and ensure optimal patient outcomes.

由于单肺通气的选择有限,在婴儿电视胸腔镜手术期间提供令人满意的肺隔离可能具有挑战性。额外的解剖病理/紊乱增加了这些小婴儿气道管理的复杂性。我们讨论了一个10个月大的婴儿计划在视频辅助下切除复发性支气管源性囊肿,该囊肿靠近喉返神经,压迫气管和支气管。相关的严重气管支气管软化症和无意中喉返神经损伤的风险需要谨慎操作,需要个性化的方法来辅助手术。本文旨在概述该婴儿术中遇到的几个气道挑战,从而为此类病例的管理文献做出贡献。虽然必须量身定制的管理策略,以个别情况下,我们努力导航复杂的复杂性,确保最佳的病人的结果。
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引用次数: 0
Message from Scientific Chairman. 科学主席的话。
IF 1.2 Q4 RESPIRATORY SYSTEM Pub Date : 2025-11-01 Epub Date: 2025-11-04 DOI: 10.4103/lungindia.lungindia_756_25
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引用次数: 0
Genetic predisposition and the impact of missense genetic variants on the structural and functional protein dynamics in idiopathic pulmonary fibrosis. 遗传易感性和错义基因变异对特发性肺纤维化结构和功能蛋白动力学的影响。
IF 1.2 Q4 RESPIRATORY SYSTEM Pub Date : 2025-11-01 Epub Date: 2025-10-24 DOI: 10.4103/lungindia.lungindia_447_25
Anitha Mohanraj Barney, Barney Isaac, Devasahayam J Christopher, Balamugesh Thangakunam, Janani Balaji, Venkata Raghava Mohan, Christhunesa Soundararajan Christudass, Debashish Danda, Sumita Danda
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引用次数: 0
Pattern of care in locally advanced non-small cell lung cancer: A tertiary care experience from India. 局部晚期非小细胞肺癌的护理模式:来自印度的三级护理经验。
IF 1.2 Q4 RESPIRATORY SYSTEM Pub Date : 2025-11-01 Epub Date: 2025-10-24 DOI: 10.4103/lungindia.lungindia_70_25
Aswin Ravi, Sushmita Pathy, Supriya Mallick, Prabhat S Malik, Sunil Kumar, Rajeev Kumar
<p><strong>Introduction and objective: </strong>Heterogeneity in locally advanced (LA) Non-Small Cell Lung Cancer (NSCLC) group necessitates a multi-disciplinary approach to its management. Surgery is the standard of care treatment if resectable; otherwise, concurrent chemo-radiation (CCRT) is preferred. This audit aims to analyse various treatment strategies in real-world settings and their resultant outcomes.</p><p><strong>Materials and methods: </strong>Medical records of patients presented to the lung cancer clinic at our centre from January 2014 to December 2018 were retrieved. Cases with stage III NSCLC were included in this retrospective analysis. Demographic and clinical data, treatments offered with associated outcomes and side effects were analysed. The progression-free survival (PFS), and overall survival (OS) were computed using Kaplan-Meier survival curves. Cox proportional hazard model (univariate and multivariate) was used to assess factors affecting PFS and OS.</p><p><strong>Results: </strong>A total of 396 patients of LA NSCLC were eligible for descriptive demography; 53% of them were >60 years of age and male-to-female ratio was 4:1. The proportion of squamous cell carcinoma and adenocarcinoma were 55.8% and 31.3%, respectively. Survival analysis was limited to 310 patients who received any form of cancer treatment. Following multi-disciplinary discussions, the intent of treatment was decided to be curative in 240 of them. Upfront surgical resection was performed in 28 patients (11.6%) with 22 receiving adjuvant chemotherapy. Pre-operative chemotherapy followed by surgery was offered to 20 patients (8.3%). The majority of patients taken for definitive chemo-radiation (CTRT) were treated by induction chemotherapy followed by concurrent CTRT (46 patients = 19.2%). Sequential CTRT (SCRT) was opted for 30 patients (12.5%). Concurrent CTRT (CCRT) was received by only 12 patients (5%). Neoadjuvant chemotherapy (NACT-including preoperative and induction chemotherapy before definitive radiotherapy or CTRT) was administered to 200 patients (83.3%). Of these, 104 patients (43.3%) of NACT were not amenable to curative local treatment later on due to poor performance status (PS), comorbidities, poor cardiopulmonary reserve or logistic issues. The median follow-up was 30.7 months. Survival was assessed by intention to treat analysis. The median PFS and median OS of the curative intent group were 11.9 months (95%CI = 8.99-14.81), and 30.7 months (95%CI = 24.42-36.98), respectively. Upfront resectable patients had longer survival when compared to NACT followed by surgery. Survival outcomes for NACT followed by CCRT were superior to CCRT or SCRT. Both median OS and PFS were found to be superior with surgery plus adjuvant therapy in comparison to definitive CTRT. Long-term survival outcomes were also better with surgical resection. No significant differences in survival outcomes were observed between CCRT and SCRT approaches, likely due to the l
简介和目的:局部晚期(LA)非小细胞肺癌(NSCLC)的异质性需要多学科的治疗方法。如果可切除,手术是标准的护理治疗;否则,首选同步放化疗(CCRT)。这次审计的目的是分析各种治疗策略在现实世界的设置和他们的结果。材料与方法:检索2014年1月至2018年12月在我中心肺癌门诊就诊的患者病历。III期非小细胞肺癌病例纳入回顾性分析。分析了人口统计学和临床数据、提供的治疗方法及其相关结果和副作用。采用Kaplan-Meier生存曲线计算无进展生存期(PFS)和总生存期(OS)。采用Cox比例风险模型(单因素和多因素)评估影响PFS和OS的因素。结果:共有396例LA NSCLC患者符合描述性人口统计学;其中年龄在60岁以下的占53%,男女比例为4:1。鳞状细胞癌和腺癌的比例分别为55.8%和31.3%。生存分析仅限于310名接受任何形式癌症治疗的患者。经过多学科的讨论,其中240例的治疗目的被确定为治愈。术前手术切除28例(11.6%),辅助化疗22例。术前化疗后手术20例(8.3%)。大多数接受终期化疗放疗(CTRT)的患者采用诱导化疗后同时进行CTRT治疗(46例= 19.2%)。30例患者(12.5%)选择顺序CTRT (SCRT)。同期CTRT (CCRT)仅12例(5%)患者接受。200例(83.3%)患者接受新辅助化疗(nact -包括术前和最终放疗或CTRT前的诱导化疗)。其中,104例(43.3%)NACT患者由于表现不佳(PS)、合共病、心肺储备不良或后勤问题,后来无法进行根治性局部治疗。中位随访时间为30.7个月。通过意向治疗分析评估生存率。治疗意向组的中位PFS和中位OS分别为11.9个月(95%CI = 8.99 ~ 14.81)和30.7个月(95%CI = 24.42 ~ 36.98)。与NACT术后相比,前期可切除患者的生存期更长。NACT加CCRT的生存结果优于CCRT或SCRT。手术加辅助治疗的中位OS和PFS均优于确定的CTRT。手术切除后的长期生存结果也更好。CCRT和SCRT两种方法的生存结果没有显著差异,可能是由于CCRT组的患者数量有限。治疗方案的总体依从性为56.7%,化疗方案的总体依从性为50.4%。在多变量生存分析中,PS和接受预期治疗是重要的预后因素。有姑息意图治疗的患者的中位PFS和OS分别为6.5个月(95% CI: 4.2-12.7)和9.1个月(95% CI: 3.1-15.7)。结论:只要可行,应给予适合LA-NSCLC患者的治疗意图治疗。虽然没有进行分期比较,但当肿瘤可切除时,生存时间更长。一致的治疗方案和设备齐全的癌症设施必须到位,以避免偏离标准建议。
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引用次数: 0
ABPA in post-tuberculosis lung disease: A diagnostic pitfall or genuine entity? 结核后肺部疾病的ABPA:诊断缺陷还是真实存在?
IF 1.2 Q4 RESPIRATORY SYSTEM Pub Date : 2025-11-01 Epub Date: 2025-10-24 DOI: 10.4103/lungindia.lungindia_412_25
Inderpaul S Sehgal, Valliappan Muthu, Ritesh Agarwal
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引用次数: 0
Smoking cessation in India: A narrative review. 印度的戒烟:述评。
IF 1.2 Q4 RESPIRATORY SYSTEM Pub Date : 2025-11-01 Epub Date: 2025-10-24 DOI: 10.4103/lungindia.lungindia_571_24
Anubhuti Singh, Kislay Kishore

Tobacco is the leading preventable cause of death in the world, and India is the second largest consumer of tobacco. Smoking is associated with a myriad of respiratory diseases, including chronic obstructive pulmonary disease, asthma, pneumonia, and lung cancer. Smoking cessation is the only modality which has shown to reduce lung function decline. Despite established benefits of smoking cessation, its services in India are limited due to time constraints, lack of awareness, and unavailability of resources. Respiratory physicians play an important role in the journey of a patient willing to quit smoking through guidance, motivation, and support. More dedication, in the form of time and effort, is required from physicians' side to this end. This narrative review was performed to get a better understanding of smoking practices and cessation services in India to identify lacunae and help guide future interventions.

烟草是世界上可预防的主要死亡原因,印度是第二大烟草消费国。吸烟与许多呼吸系统疾病有关,包括慢性阻塞性肺病、哮喘、肺炎和肺癌。戒烟是唯一一种可以减少肺功能下降的方式。尽管已经确立了戒烟的好处,但由于时间限制、缺乏认识和资源匮乏,印度的戒烟服务有限。呼吸内科医生在病人愿意通过指导、动机和支持戒烟的过程中起着重要的作用。为此,医生方面需要投入更多的时间和精力。进行这一叙述性审查是为了更好地了解印度的吸烟习惯和戒烟服务,以确定空白并帮助指导未来的干预措施。
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引用次数: 0
Does echinococcosis in a tanner represent a neglected occupational lung disease? 皮匠棘球蚴病是一种被忽视的职业性肺病吗?
IF 1.2 Q4 RESPIRATORY SYSTEM Pub Date : 2025-11-01 Epub Date: 2025-10-24 DOI: 10.4103/lungindia.lungindia_320_25
Pavlos Siozos, Sofoklis Mitsos, Thomas Raptakis, Anna Karakatsani
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引用次数: 0
期刊
Lung India
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