Pub Date : 2023-11-18DOI: 10.1101/2023.03.21.533722
Chulhwan Kwak, Gina M Finan, Yu Rim Park, Anjali Garg, Oscar Harari, Ji Young Mun, Hyun-Woo Rhee, Tae-Wan Kim
Triggering receptor expressed on myeloid cells 2 (TREM2) plays a central role in microglial biology and the pathogenesis of Alzheimer's disease (AD). Besides DNAX-activating protein 12 (DAP12), a communal adaptor for TREM2 and many other receptors, other cellular interactors of TREM2 remain largely elusive. We employed a 'proximity labeling' approach using a biotin ligase, TurboID, for mapping protein-protein interactions in live mammalian cells. We discovered novel TREM2-proximal proteins with diverse functions, including those localized to the Mitochondria-ER contact sites (MERCs), a dynamic subcellular 'hub' implicated in a number of crucial cell physiology such as lipid metabolism. TREM2 deficiency alters the thickness (inter-organelle distance) of MERCs, a structural parameter of metabolic state, in microglia derived from human induced pluripotent stem cells. Our TurboID-based TREM2 interactome study suggest novel roles for TREM2 in the structural plasticity of the MERCs, raising the possibility that dysregulation of MERC-related TREM2 functions contribute to AD pathobiology.
{"title":"Proximity Proteome Analysis Reveals Novel TREM2 Interactors in the ER-Mitochondria Interface of Human Microglia.","authors":"Chulhwan Kwak, Gina M Finan, Yu Rim Park, Anjali Garg, Oscar Harari, Ji Young Mun, Hyun-Woo Rhee, Tae-Wan Kim","doi":"10.1101/2023.03.21.533722","DOIUrl":"10.1101/2023.03.21.533722","url":null,"abstract":"<p><p>Triggering receptor expressed on myeloid cells 2 (TREM2) plays a central role in microglial biology and the pathogenesis of Alzheimer's disease (AD). Besides DNAX-activating protein 12 (DAP12), a communal adaptor for TREM2 and many other receptors, other cellular interactors of TREM2 remain largely elusive. We employed a 'proximity labeling' approach using a biotin ligase, TurboID, for mapping protein-protein interactions in live mammalian cells. We discovered novel TREM2-proximal proteins with diverse functions, including those localized to the Mitochondria-ER contact sites (MERCs), a dynamic subcellular 'hub' implicated in a number of crucial cell physiology such as lipid metabolism. TREM2 deficiency alters the thickness (inter-organelle distance) of MERCs, a structural parameter of metabolic state, in microglia derived from human induced pluripotent stem cells. Our TurboID-based TREM2 interactome study suggest novel roles for TREM2 in the structural plasticity of the MERCs, raising the possibility that dysregulation of MERC-related TREM2 functions contribute to AD pathobiology.</p>","PeriodicalId":47733,"journal":{"name":"Canadian Journal of Behavioural Science-Revue Canadienne Des Sciences Du Comportement","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80134745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Les effets d’une intervention basée sur la pleine conscience sur le bien-être des femmes enceintes, l’adaptation à la parentalité et le développement des enfants : Une étude périnatale et longitudinale.","authors":"M. Tremblay, Nicolas Berthelot","doi":"10.1037/cbs0000376","DOIUrl":"https://doi.org/10.1037/cbs0000376","url":null,"abstract":"","PeriodicalId":47733,"journal":{"name":"Canadian Journal of Behavioural Science-Revue Canadienne Des Sciences Du Comportement","volume":"1 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76603590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Béatrice Mailloux, A. Brassard, Ariane Audet, Katherine Péloquin, C. Savard, Marie-Ève Daspe, Marie-France Lafontaine, Natacha Godbout
{"title":"Comportements suicidaires chez les hommes en demande d’aide : Rôles des traumatismes en enfance, de l’attachement et des impacts perçus de la pandémie.","authors":"Béatrice Mailloux, A. Brassard, Ariane Audet, Katherine Péloquin, C. Savard, Marie-Ève Daspe, Marie-France Lafontaine, Natacha Godbout","doi":"10.1037/cbs0000383","DOIUrl":"https://doi.org/10.1037/cbs0000383","url":null,"abstract":"","PeriodicalId":47733,"journal":{"name":"Canadian Journal of Behavioural Science-Revue Canadienne Des Sciences Du Comportement","volume":"14 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72597473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"L’évaluation de la validité de la performance en neuropsychologie clinique : Sondage sur les pratiques et les croyances des neuropsychologues québécois.","authors":"C. Richer, G. Forest","doi":"10.1037/cbs0000380","DOIUrl":"https://doi.org/10.1037/cbs0000380","url":null,"abstract":"","PeriodicalId":47733,"journal":{"name":"Canadian Journal of Behavioural Science-Revue Canadienne Des Sciences Du Comportement","volume":"17 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88517174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicole K. Legg, Andrew C. Switzer, Zachary Senay, Jennifer T. H. Reeves, P. Phiri, S. Rathod, Theone S. E. Paterson, Brianna J. Turner
{"title":"Prevalence, correlates, and drivers of COVID-19 vaccine hesitancy among Canadians.","authors":"Nicole K. Legg, Andrew C. Switzer, Zachary Senay, Jennifer T. H. Reeves, P. Phiri, S. Rathod, Theone S. E. Paterson, Brianna J. Turner","doi":"10.1037/cbs0000377","DOIUrl":"https://doi.org/10.1037/cbs0000377","url":null,"abstract":"","PeriodicalId":47733,"journal":{"name":"Canadian Journal of Behavioural Science-Revue Canadienne Des Sciences Du Comportement","volume":"90 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80417558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annie Paquet, F. Fenouillet, J. Binfet, Sonia Lorant, Y. Paquet
{"title":"Échelle de perception de la bienveillance à l’école : Validation française de la « School Kindness Scale ».","authors":"Annie Paquet, F. Fenouillet, J. Binfet, Sonia Lorant, Y. Paquet","doi":"10.1037/cbs0000378","DOIUrl":"https://doi.org/10.1037/cbs0000378","url":null,"abstract":"","PeriodicalId":47733,"journal":{"name":"Canadian Journal of Behavioural Science-Revue Canadienne Des Sciences Du Comportement","volume":"91 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73791013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A brief intervention teaching false polarization and naïve realism reduces perceived political polarization.","authors":"C. W. Blatz","doi":"10.1037/cbs0000379","DOIUrl":"https://doi.org/10.1037/cbs0000379","url":null,"abstract":"","PeriodicalId":47733,"journal":{"name":"Canadian Journal of Behavioural Science-Revue Canadienne Des Sciences Du Comportement","volume":"8 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88966145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Simon A. Houle, Arya Shafei, István Tóth‐Király, C. Vandenberghe, A. Morin
This study studied profiles of workplace affective commitment (WAC) among organizational newcomers (N=443). We estimated these profiles from newcomers’ specific levels of WAC directed at eight targets (i.e., organization, supervisor, coworkers, career planning, career advancement, customers, profession, and tasks) and their global levels of commitment to their work life. This approach allowed us to detect whether these profiles would evidence congruence vs. incompatibility among targets, and whether WAC to the organization would emerge as a primary vs. one of many targets. This study also investigated whether employee socialization (i.e., organization, coworkers, and role) predicted membership into desirable profiles. Finally, to investigate the complementary, synergistic, and/or competing effects of WAC profiles, we tested their associations with job performance, turnover intentions, and life satisfaction. Latent profile analyses revealed five profiles displaying compatibility and conflict amongst targets and positioning the organization as one of many targets: (1) Globally committed to the work life with a professional career orientation; (2) Globally committed to the work life with a social orientation; (3) Globally uncommitted to the work life with a professional orientation; (4) Globally uncommitted to the work life with a career planning and customer orientation; (5) Globally committed to the work life with an upward drive. With exceptions involving role socialization, all forms of socialization predicted membership into more desirable WAC profiles. Profiles characterized by higher global levels of WAC were also associated with more desirable outcomes. We finally found evidence for complementarity, synergy, and competition among WAC targets in terms of outcomes.
{"title":"Newcomers’ profiles of workplace affective commitment.","authors":"Simon A. Houle, Arya Shafei, István Tóth‐Király, C. Vandenberghe, A. Morin","doi":"10.1037/cbs0000386","DOIUrl":"https://doi.org/10.1037/cbs0000386","url":null,"abstract":"This study studied profiles of workplace affective commitment (WAC) among organizational newcomers (N=443). We estimated these profiles from newcomers’ specific levels of WAC directed at eight targets (i.e., organization, supervisor, coworkers, career planning, career advancement, customers, profession, and tasks) and their global levels of commitment to their work life. This approach allowed us to detect whether these profiles would evidence congruence vs. incompatibility among targets, and whether WAC to the organization would emerge as a primary vs. one of many targets. This study also investigated whether employee socialization (i.e., organization, coworkers, and role) predicted membership into desirable profiles. Finally, to investigate the complementary, synergistic, and/or competing effects of WAC profiles, we tested their associations with job performance, turnover intentions, and life satisfaction. Latent profile analyses revealed five profiles displaying compatibility and conflict amongst targets and positioning the organization as one of many targets: (1) Globally committed to the work life with a professional career orientation; (2) Globally committed to the work life with a social orientation; (3) Globally uncommitted to the work life with a professional orientation; (4) Globally uncommitted to the work life with a career planning and customer orientation; (5) Globally committed to the work life with an upward drive. With exceptions involving role socialization, all forms of socialization predicted membership into more desirable WAC profiles. Profiles characterized by higher global levels of WAC were also associated with more desirable outcomes. We finally found evidence for complementarity, synergy, and competition among WAC targets in terms of outcomes.","PeriodicalId":47733,"journal":{"name":"Canadian Journal of Behavioural Science-Revue Canadienne Des Sciences Du Comportement","volume":"37 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87526971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Candice Geraldy, Alice Martinet, S. Berjot, Delphine Deguerne, T. Huyghebaert-Zouaghi
{"title":"Passionnés à quel prix ? Passion pour le travail et interface vie professionnelle-vie personnelle des exploitants agricoles.","authors":"Candice Geraldy, Alice Martinet, S. Berjot, Delphine Deguerne, T. Huyghebaert-Zouaghi","doi":"10.1037/cbs0000375","DOIUrl":"https://doi.org/10.1037/cbs0000375","url":null,"abstract":"","PeriodicalId":47733,"journal":{"name":"Canadian Journal of Behavioural Science-Revue Canadienne Des Sciences Du Comportement","volume":"18 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88638418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haley E. Green, Andrew R. Daoust, M. Vandermeer, Pan Liu, Kasey Stanton, K. Harkness, E. Hayden
{"title":"Characterizing and predicting Canadian adolescents’ internalizing symptoms in the first year of the COVID-19 pandemic.","authors":"Haley E. Green, Andrew R. Daoust, M. Vandermeer, Pan Liu, Kasey Stanton, K. Harkness, E. Hayden","doi":"10.1037/cbs0000381","DOIUrl":"https://doi.org/10.1037/cbs0000381","url":null,"abstract":"","PeriodicalId":47733,"journal":{"name":"Canadian Journal of Behavioural Science-Revue Canadienne Des Sciences Du Comportement","volume":"189 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76537073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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