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The Effectiveness of Goal-Oriented Dual Task Proprioceptive Training in Subacute Stroke: A Retrospective Observational Study. 以目标为导向的双任务知觉训练对亚急性中风的疗效:回顾性观察研究
IF 1.3 Q1 REHABILITATION Pub Date : 2024-02-01 Epub Date: 2024-02-28 DOI: 10.5535/arm.23086
Rita Chiaramonte, Salvatore D'Amico, Salvatore Caramma, Giuseppina Grasso, Simona Pirrone, Maria Giovanna Ronsisvalle, Marco Bonfiglio

Objective: To show the effectiveness of goal-oriented proprioceptive training in subacute stroke for balance, autonomy, and fall risk.

Methods: Out a total of 35 patients, consistent in age (75.31±8.65 years), type of stroke (ischemic, 3 to 11 weeks before), and motor impairment, 18 patients underwent solely proprioceptive rehabilitation, the other 17 dual task exercises. The study assessed autonomy using Barthel Index, fall risk with Timed Up and Go Test (TUG), balance through Berg Balance Scale (BBS) and Tinetti test.

Results: After two months, significant improvements were recorded in Barthel Index, BBS (p<0.0001), Tinetti test (p<0.0001 in dual task group, p=0.0029 in single task group), and TUG (p=0.0052 in dual task group, p=0.0020 in single task group) in both groups. Comparing the two groups, dual task group showed a significant difference in Tinetti balance assessment (p=0.0052), between the total score of Tinetti test and TUG in single (p=0.0271), and dual task (p=0.0235). Likewise, Tinetti gait test was significantly related to TUG in single (p=0.0536), and dual task (p=0.0466), while Tinetti balance test to Barthel Index (p=0.0394), BBS (p<0.0001), and TUG in single (p=0.0219), and dual task (p=0.0196). Lastly, there is a positive correlation of the use of aids with BBS (p=0.0074), and total score of Tinetti test (p=0.0160).

Conclusion: In subacute stroke, goal-oriented proprioceptive training improved balance, but only partially autonomy. Furthermore, the use of aids after dual-task exercises improved recovery of balance, but did not reduced falls.

目的方法:在年龄(75.31±8.65 岁)、中风类型(缺血性,3 至 11 周前)和运动障碍一致的 35 名患者中,18 名患者只接受了本体感觉训练:在年龄(75.31±8.65 岁)、中风类型(缺血性,3 至 11 周前)和运动障碍一致的 35 名患者中,18 名患者只接受本体感觉康复训练,其他 17 名患者接受双重任务训练。研究使用巴特尔指数(Barthel Index)评估自理能力,使用定时起立行走测试(TUG)评估跌倒风险,使用伯格平衡量表(BBS)和蒂内蒂测试评估平衡能力:结果:两个月后,巴特尔指数和 BBS(p)均有明显改善:结论:在亚急性中风患者中,以目标为导向的本体感觉训练可改善平衡能力,但只能改善部分自理能力。此外,在双任务训练后使用辅助工具可改善平衡的恢复,但并不能减少跌倒。
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引用次数: 0
Letter to the Editor: Eccentric Versus Concentric Exercises in Patients With Rheumatoid Arthritis and Rotator Cuff Tendinopathy: A Randomized Comparative Study. 致编辑的信:类风湿性关节炎和肩袖肌腱病患者的偏心运动与同心运动:随机比较研究。
IF 1.3 Q1 REHABILITATION Pub Date : 2024-02-01 Epub Date: 2024-02-28 DOI: 10.5535/arm.230035
Vanshika Agarwal, Jeyanthi S, Adarsh Sharma
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引用次数: 0
The Korean Version of the Oxford Cognitive Screen (K-OCS) Normative Study. 韩国版牛津认知筛查(K-OCS)规范研究。
IF 1.3 Q1 REHABILITATION Pub Date : 2024-02-01 Epub Date: 2024-02-28 DOI: 10.5535/arm.23149
Eunyoung Cho, Sungwon Choi, Nele Demeyere, Sean Soon Sung Hwang, MinYoung Kim

Objective: To generate a Korean version of the Oxford Cognitive Screen (K-OCS) and obtain cutoff scores that determine the impairment of each subdomain. Post-stroke cognitive impairment (PSCI) negatively impacts the rehabilitation process and independence in daily life. Its obscure manifestations require effective screening for appropriate rehabilitation. However, in most rehabilitation clinics, psychological evaluation tools for Alzheimer's dementia have been used without such considerations. The OCS is a screening assessment tool for PSCI and vascular dementia that can evaluate the cognitive domains most often affected by stroke, including language, attention, memory, praxis, and numerical cognition. It comprises 10 subtasks and enables quick and effective cognitive evaluation.

Methods: The K-OCS, which considers Korea's unique cultural and linguistic characteristics, was developed with the approval and cooperation of the original author. Enrollment of participants without disabilities was announced at Duksung Women's University, Yongin Sevrance Hospital, CHA Bundang Medical Center. The study was conducted between September 2020 and March 2022 on 97 male and female participants aged ≥30 years.

Results: All the 97 participants completed the task. In this study, the 5th percentile score was presumed to be the cutoff value for each score, and the values are provided here. The cutoff score for each OCS subtask was similar to that of the original British version.

Conclusion: We suggest the usability of the K-OCS as a screening tool for PSCI by providing the cutoff value of each subtask.

目的生成韩国版牛津认知筛查(K-OCS),并获得确定各子领域损伤程度的临界分数。脑卒中后认知障碍(PSCI)会对康复过程和日常生活的独立性产生负面影响。其不明显的表现需要有效的筛查,以便进行适当的康复治疗。然而,在大多数康复诊所中,针对阿尔茨海默氏症痴呆症的心理评估工具在使用时并没有考虑到这些因素。OCS 是一种针对 PSCI 和血管性痴呆的筛查评估工具,可评估最常受中风影响的认知领域,包括语言、注意力、记忆、练习和数字认知。它由 10 个子任务组成,可进行快速有效的认知评估:K-OCS 考虑了韩国独特的文化和语言特点,是在原作者的同意和合作下开发的。在都成女子大学、龙仁Sevrance医院和CHA盆唐医疗中心公布了无残疾参与者的招募信息。研究在 2020 年 9 月至 2022 年 3 月期间进行,97 名男女参与者的年龄均≥30 岁:所有 97 名参与者都完成了任务。在本研究中,每项得分的临界值假定为第 5 百分位数,并在此提供该值。OCS 各子任务的临界值与英国原版的临界值相似:我们建议将 K-OCS 作为 PSCI 筛查工具,提供每个子任务的临界值。
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引用次数: 0
Epidemiology of Traumatic Spinal Cord Injury in the Himalayan Range and Sub-Himalayan region: A Retrospective Hospital Data-Based Study. 喜马拉雅山脉和次喜马拉雅山脉地区外伤性脊髓损伤的流行病学:基于医院数据的回顾性研究。
IF 1.3 Q1 REHABILITATION Pub Date : 2024-02-01 Epub Date: 2023-12-26 DOI: 10.5535/arm.23107
Osama Neyaz, Vinay Kanaujia, Raj Kumar Yadav, Bhaskar Sarkar, Md Quamar Azam, Pankaj Kandwal

Objective: To compile epidemiological characteristics of traumatic spinal cord injury (TSCI) in the Northern Indian Himalayan regions and Sub-Himalayan planes.

Methods: The present study is a retrospective, cross-sectional descriptive analysis based on hospital data conducted at the Department of Physical Medicine and Rehabilitation and Spine Unit of Trauma Centre in a tertiary care hospital in Uttarakhand, India. People hospitalized at the tertiary care center between August 2018 and November 2021 are included in the study sample. A prestructured proforma was employed for the evaluation, including demographic and epidemiological characteristics.

Results: TSCI was found in 167 out of 3,120 trauma patients. The mean age of people with TSCI was 33.5±13.3, with a male-to-female ratio of 2.4:1. Eighty-three participants (49.7%) were from the plains, while the hilly region accounts for 50.3%. People from the plains had a 2.9:1 rural-to-urban ratio, whereas the hilly region had a 6:1 ratio. The overall most prevalent cause was Falls (59.3%), followed by road traffic accidents (RTAs) (35.9%). RTAs (57.2%) were the most common cause of TSCI in the plains' urban regions, while Falls (58.1%) were more common in rural plains. In both urban (66.6%) and rural (65.3%) parts of the hilly region, falls were the most common cause.

Conclusion: TSCI is more common in young males, especially in rural hilly areas. Falls rather than RTAs are the major cause.

目的汇编印度北部喜马拉雅地区和次喜马拉雅地区创伤性脊髓损伤(TSCI)的流行病学特征:本研究是一项回顾性横断面描述性分析,以印度北阿坎德邦一家三级医院物理医学与康复科和创伤中心脊柱室的住院数据为基础。研究样本包括 2018 年 8 月至 2021 年 11 月期间在该三级医疗中心住院的患者。研究采用预结构化表格进行评估,包括人口统计学和流行病学特征:在3120名创伤患者中,有167人发现了TSCI。TSCI患者的平均年龄为(33.5±13.3)岁,男女比例为2.4:1。83名参与者(49.7%)来自平原地区,50.3%来自丘陵地区。平原地区的城乡居民比例为 2.9:1,而丘陵地区的城乡居民比例为 6:1。总的来说,最常见的原因是坠落(59.3%),其次是道路交通事故(35.9%)。在平原城市地区,道路交通事故(57.2%)是导致 TSCI 的最常见原因,而跌倒(58.1%)在平原农村地区更为常见。在丘陵地区的城市(66.6%)和农村(65.3%),跌倒是最常见的原因:结论:TSCI 在年轻男性中更为常见,尤其是在农村丘陵地区。结论:TSCI 在年轻男性中更为常见,尤其是在农村丘陵地区。
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引用次数: 0
Health-Related Quality of Life is Associated With Pain, Kinesiophobia, and Physical Activity in Individuals Who Underwent Cervical Spine Surgery. 颈椎手术患者的健康相关生活质量与疼痛、运动恐惧和体育锻炼有关。
IF 2.1 Q1 REHABILITATION Pub Date : 2024-02-01 Epub Date: 2024-02-08 DOI: 10.5535/arm.23142
Daisuke Higuchi, Yu Kondo, Yuta Watanabe, Takahiro Miki

Objective: To determine the association between health-related quality of life (HRQOL) and neck pain, kinesiophobia, and modalities of physical activity in individuals with postoperative degenerative cervical myelopathy and radiculopathy (DCM/R) because postoperative pain after cervical spine surgery is likely to persist, causing kinesiophobia and avoidance of physical activity.

Methods: A questionnaire was distributed to 280 individuals with DCM/R. The questionnaire comprised the following four items: HRQOL (EuroQol 5-dimensions 5-level), neck pain (numerical rating scale [NRS]), kinesiophobia (11-item Tampa Scale for Kinesiophobia [TSK-11]), and physical activity (paid work, light exercise, walking, strength training, and gardening). Hierarchical multiple regression analysis was performed using the NRS, TSK-11, and physical activity as independent variables.

Results: In total, 126 individuals provided analyzable responses (45.0%). After including the NRS score as an independent variable to the multiple regression equation for participants' background, the independent rate of the regression equation significantly improved by only 4.1% (R2=0.153). The addition of the TSK-11 score significantly improved this effect by 11.1% (R2=0.264). Finally, the addition of physical activity also significantly improved the explanatory rate by 9.9% (R2=0.363).

Conclusion: Neck pain, kinesiophobia, and physical activity (specifically paid work and walking) were independently associated with HRQOL in individuals with postoperative DCM/R.

目的目的:确定颈椎退行性脊髓病和根性颈椎病(DCM/R)术后患者的健康相关生活质量(HRQOL)与颈部疼痛、运动恐惧和体育锻炼方式之间的关系,因为颈椎手术后的疼痛可能会持续存在,导致运动恐惧和避免体育锻炼:方法: 向 280 名 DCM/R 患者发放了调查问卷。调查问卷包括以下四个项目:HRQOL(EuroQol 5维度)、颈部疼痛(数字评分量表[NRS])、运动恐惧(11个项目的坦帕运动恐惧量表[TSK-11])和体力活动(有偿工作、轻度锻炼、步行、力量训练和园艺)。以 NRS、TSK-11 和体力活动为自变量,进行了层次多元回归分析:共有 126 人提供了可分析的回答(45.0%)。将 NRS 分数作为自变量纳入参与者背景的多元回归方程后,回归方程的独立率仅显著提高了 4.1%(R2=0.153)。加入 TSK-11 评分后,这一效果明显提高了 11.1%(R2=0.264)。最后,增加体育锻炼也能显著提高解释率 9.9% (R2=0.363):结论:颈部疼痛、运动恐惧和体力活动(尤其是有偿工作和步行)与术后 DCM/R 患者的 HRQOL 独立相关。
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引用次数: 0
Predicting Age of Independent Walking in Preterm Infants: A Longitudinal Study Using Neonatal Characteristics and Motor Development Variables. 早产儿独立行走年龄的预测:利用新生儿特征和运动发育变量的纵向研究
IF 1.3 Q1 REHABILITATION Pub Date : 2024-02-01 Epub Date: 2024-02-08 DOI: 10.5535/arm.230012
Noppharath Sangkarit, Weerasak Tapanya, Arunrat Srithawong, Patchareeya Amput, Boonsita Suwannakul

Objective: To formulate an equation estimating months to independent walking in moderate to late preterm infants based on neonatal characteristics and gross motor development from 7 months to independent walking.

Methods: Sixty infants born between 32 to 36 weeks were assessed using Alberta Infant Motor Scale (AIMS) for gross motor development. Neonatal characteristics were recorded at 7 months, and caregiver-reported independent walking onset. Pearson correlation analyzed age, AIMS scores, and neonatal factors. Multiple regression developed the prediction equation.

Results: The equation for independent walking onset, which included gestational age (GA) at birth, total AIMS score at 10 months of age (10th AIMS), and birth head circumference (BHC), exhibited a strong correlation (r=0.707) and had a predictive power of 50.0%. The equation is as follows: age onset of independent walking (months)=33.157, -0.296 (GA), -0.132 (10th AIMS), -0.196 (BHC), with an estimation error of 0.631 months.

Conclusion: Neonatal characteristics, such as GA, 10th AIMS, and BHC, are key determinants in estimating the onset of independent walking in moderate to late preterm infants.

目的根据新生儿特征和从 7 个月到独立行走的粗大运动发育情况,制定中晚期早产儿独立行走月龄的估算公式:方法:使用阿尔伯塔婴儿运动量表(AIMS)对出生 32 至 36 周的 60 名婴儿的粗大运动发育情况进行评估。记录7个月时的新生儿特征以及护理人员报告的独立行走起始时间。皮尔逊相关分析了年龄、AIMS 评分和新生儿因素。多元回归建立了预测方程:独立行走起始方程包括出生时的胎龄(GA)、10 个月时的 AIMS 总分(第 10 次 AIMS)和出生时的头围(BHC),显示出很强的相关性(r=0.707),预测能力为 50.0%。等式如下:开始独立行走的年龄(月)=33.157,-0.296(GA),-0.132(第 10 次 AIMS),-0.196(BHC),估计误差为 0.631 个月:GA、第 10 次 AIMS 和 BHC 等新生儿特征是估计中晚期早产儿开始独立行走的关键决定因素。
{"title":"Predicting Age of Independent Walking in Preterm Infants: A Longitudinal Study Using Neonatal Characteristics and Motor Development Variables.","authors":"Noppharath Sangkarit, Weerasak Tapanya, Arunrat Srithawong, Patchareeya Amput, Boonsita Suwannakul","doi":"10.5535/arm.230012","DOIUrl":"10.5535/arm.230012","url":null,"abstract":"<p><strong>Objective: </strong>To formulate an equation estimating months to independent walking in moderate to late preterm infants based on neonatal characteristics and gross motor development from 7 months to independent walking.</p><p><strong>Methods: </strong>Sixty infants born between 32 to 36 weeks were assessed using Alberta Infant Motor Scale (AIMS) for gross motor development. Neonatal characteristics were recorded at 7 months, and caregiver-reported independent walking onset. Pearson correlation analyzed age, AIMS scores, and neonatal factors. Multiple regression developed the prediction equation.</p><p><strong>Results: </strong>The equation for independent walking onset, which included gestational age (GA) at birth, total AIMS score at 10 months of age (10th AIMS), and birth head circumference (BHC), exhibited a strong correlation (r=0.707) and had a predictive power of 50.0%. The equation is as follows: age onset of independent walking (months)=33.157, -0.296 (GA), -0.132 (10th AIMS), -0.196 (BHC), with an estimation error of 0.631 months.</p><p><strong>Conclusion: </strong>Neonatal characteristics, such as GA, 10th AIMS, and BHC, are key determinants in estimating the onset of independent walking in moderate to late preterm infants.</p>","PeriodicalId":47738,"journal":{"name":"Annals of Rehabilitation Medicine-ARM","volume":" ","pages":"65-74"},"PeriodicalIF":1.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10915304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139703726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response: Eccentric Versus Concentric Exercises in Patients With Rheumatoid Arthritis and Rotator Cuff Tendinopathy: A Randomized Comparative Study (Ann Rehabil Med 2023;47:26-35). 反应:类风湿性关节炎和肩袖肌腱病患者的偏心运动与同心运动:随机比较研究》(Ann Rehabil Med 2023;47:26-35)。
IF 1.3 Q1 REHABILITATION Pub Date : 2024-02-01 Epub Date: 2024-02-22 DOI: 10.5535/arm.240007
Mina Magdy Wahba, Mona Selim, Mohammed Moustafa Hegazy, Rasmia Elgohary, Mohammed Shawki Abdelsalam
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引用次数: 0
Effectiveness of Community-Based Rehabilitation (CBR) Centers for Improving Physical Fitness for Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis. 社区康复中心(CBR)对改善社区老年人体质的效果:系统回顾与元分析》。
IF 1.3 Q1 REHABILITATION Pub Date : 2024-02-01 Epub Date: 2024-02-28 DOI: 10.5535/arm.23148
Wei Xin, Dan Xu, Zulin Dou, Angela Jacques, Josephine Umbella, Anne-Marie Hill

To synthesise the best available evidence for the effectiveness of interventions delivered in community-based rehabilitation (CBR) centers on physical fitness, for community-dwelling older adults living in Asian countries. This study is a systematic review and meta-analysis. Seven English and two Chinese electronic databases were searched for randomised controlled trials (RCTs) and quasi-experimental studies that were conducted by centers providing CBR. Independent reviewers screened, quality-appraised and extracted data. The primary outcome was physical fitness measured by validated assessment tools, including the Timed Up and Go Test (TUG), gait speed, hand grip strength, Functional Reach Test (FRT), and one-leg standing test. Assessments of activity of daily living and quality of life using tools including the Barthel Index, Short Form (SF)-12, and SF-36 were secondary outcomes. After screening 5,272 studies, 29 studies were included (16 RCTs, 13 quasi-experimental studies) from four countries. Meta-analyses found that CBR programs significantly decreased TUG time (mean difference [MD], -1.89 seconds; 95% confidence interval [95% CI], -2.84 to -0.94; I2=0%; Z=3.90, p<0.0001), improved gait speed (MD, 0.10 m/s; 95% CI, 0.01-0.18; I2=0%; Z=2.26, p=0.02), and increased one-leg standing time (MD, 2.81 seconds; 95% CI, 0.41-5.22; I2=0%; Z=2.29, p=0.02). Handgrip strength and FRT showed no statistically significant improvement in the meta-analyses. CBR may improve aspects of physical fitness for older adults in Asian countries. However, variability in intervention components and measurement tools reduced the ability to pool individual studies. Further trials are required with robust designs including standardised measures of physical fitness.

综合现有的最佳证据,说明社区康复中心为亚洲国家居住在社区的老年人提供的体能干预措施的有效性。本研究是一项系统回顾和荟萃分析。研究人员在七个英文和两个中文电子数据库中搜索了由社区康复中心开展的随机对照试验(RCT)和准实验研究。独立审稿人对数据进行了筛选、质量评估和提取。主要研究结果是通过有效的评估工具测量体能,包括定时起立行走测试(TUG)、步态速度、手握力、功能性前伸测试(FRT)和单腿站立测试。使用巴特尔指数(Barthel Index)、简表(SF)-12 和 SF-36 等工具对日常生活活动和生活质量进行评估是次要结果。在筛选了 5272 项研究后,共纳入了来自 4 个国家的 29 项研究(16 项研究性临床试验,13 项准实验研究)。元分析发现,CBR 项目可显著缩短 TUG 时间(平均差异 [MD],-1.89 秒;95% 置信区间 [95%CI],-2.84 至 -0.94;I2=0%;Z=3.90,p
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引用次数: 0
Early is Better, Then, How Early and How to Apply: Practical Approach of Botulinum Toxin Injection. 越早越好,如何越早及如何应用:肉毒毒素注射的实用方法。
IF 1.3 Q1 REHABILITATION Pub Date : 2023-12-01 Epub Date: 2023-12-05 DOI: 10.5535/arm.230010
Joon-Ho Shin
{"title":"Early is Better, Then, How Early and How to Apply: Practical Approach of Botulinum Toxin Injection.","authors":"Joon-Ho Shin","doi":"10.5535/arm.230010","DOIUrl":"10.5535/arm.230010","url":null,"abstract":"","PeriodicalId":47738,"journal":{"name":"Annals of Rehabilitation Medicine-ARM","volume":" ","pages":"439-440"},"PeriodicalIF":1.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10767213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138483220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preclinical Study of Dual-Wavelength Light-Emitting Diode Therapy in an Osteoarthritis Rat Model. 骨关节炎大鼠模型中双波长发光二极管疗法的临床前研究
IF 1.3 Q1 REHABILITATION Pub Date : 2023-12-01 Epub Date: 2023-12-06 DOI: 10.5535/arm.23138
Won Woo Choi, Sung Hoon Kim, Ji Hyun Kim, Kyungmin Kim, Sun Jung Kim, Minwoo Kim, Han-Sung Kim, Hana Lee, Ji Yong Lee, Sang Yeol Yong

Objective: To evaluate the efficacy of light-emitting diode (LED) and their dual-wavelengths as a treatment strategy for osteoarthritis.

Methods: We induced osteoarthritis in male Sprague-Dawley rats by intra-articular injection of sodium iodoacetate into the right rear knee joint. The animals with lesions were divided into an untreated group and an LED-treated group (n=7 each). In the LED-treated group, the lesioned knee was irradiated with lasers (850 and 940 nm) and dose (3.15 J/cm2) for 20 minutes per session, twice a week for 4 weeks. Knee joint tissues were stained and scanned using an in vivo micro-computed tomography (CT) scanner. Serum interleukin (IL)-6 and IL-18 levels were determined using enzyme-linked immuno-sorbent assay. Several functional tests (lines crossed, rotational movement, rearing, and latency to remain rotating rod) were performed 24 hours before LED treatment and at 7, 14, 21, and 28 days after treatment.

Results: LED-treated rats showed improved locomotor function and suppressed matrix-degrading cytokines. Micro-CT images indicated that LED therapy had a preserving effect on cartilage and cortical bone.

Conclusion: LED treatment using wavelengths of 850 and 940 nm resulted in significant functional, anatomical, and histologic improvements without adverse events in a rat model. Further research is required to determine the optimal wavelength, duration, and combination method, which will maximize treatment effectiveness.

目的:评估发光二极管及其双波长作为骨关节炎治疗策略的疗效:评估发光二极管(LED)及其双波长作为骨关节炎治疗策略的疗效:在雄性 Sprague-Dawley 大鼠右后膝关节内注射碘乙酸钠,诱发骨关节炎。将有病变的动物分为未处理组和 LED 处理组(各 7 只)。在LED治疗组,用激光(850和940纳米)和剂量(3.15焦耳/平方厘米)照射病变膝关节,每次20分钟,每周两次,连续4周。对膝关节组织进行染色,并使用体内微型计算机断层扫描(CT)扫描仪进行扫描。使用酶联免疫吸附法测定血清白细胞介素(IL)-6和IL-18水平。在LED治疗前24小时和治疗后7、14、21和28天进行了几项功能测试(过线、旋转运动、饲养和保持旋转杆的潜伏期):结果:经 LED 治疗的大鼠运动功能得到改善,基质降解细胞因子受到抑制。显微 CT 图像显示,LED 治疗对软骨和皮质骨有保护作用:结论:在大鼠模型中使用波长为 850 和 940 nm 的 LED 治疗可显著改善功能、解剖和组织学状况,且无不良反应。需要进一步研究确定最佳波长、持续时间和组合方法,以最大限度地提高治疗效果。
{"title":"Preclinical Study of Dual-Wavelength Light-Emitting Diode Therapy in an Osteoarthritis Rat Model.","authors":"Won Woo Choi, Sung Hoon Kim, Ji Hyun Kim, Kyungmin Kim, Sun Jung Kim, Minwoo Kim, Han-Sung Kim, Hana Lee, Ji Yong Lee, Sang Yeol Yong","doi":"10.5535/arm.23138","DOIUrl":"10.5535/arm.23138","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of light-emitting diode (LED) and their dual-wavelengths as a treatment strategy for osteoarthritis.</p><p><strong>Methods: </strong>We induced osteoarthritis in male Sprague-Dawley rats by intra-articular injection of sodium iodoacetate into the right rear knee joint. The animals with lesions were divided into an untreated group and an LED-treated group (n=7 each). In the LED-treated group, the lesioned knee was irradiated with lasers (850 and 940 nm) and dose (3.15 J/cm2) for 20 minutes per session, twice a week for 4 weeks. Knee joint tissues were stained and scanned using an in vivo micro-computed tomography (CT) scanner. Serum interleukin (IL)-6 and IL-18 levels were determined using enzyme-linked immuno-sorbent assay. Several functional tests (lines crossed, rotational movement, rearing, and latency to remain rotating rod) were performed 24 hours before LED treatment and at 7, 14, 21, and 28 days after treatment.</p><p><strong>Results: </strong>LED-treated rats showed improved locomotor function and suppressed matrix-degrading cytokines. Micro-CT images indicated that LED therapy had a preserving effect on cartilage and cortical bone.</p><p><strong>Conclusion: </strong>LED treatment using wavelengths of 850 and 940 nm resulted in significant functional, anatomical, and histologic improvements without adverse events in a rat model. Further research is required to determine the optimal wavelength, duration, and combination method, which will maximize treatment effectiveness.</p>","PeriodicalId":47738,"journal":{"name":"Annals of Rehabilitation Medicine-ARM","volume":" ","pages":"483-492"},"PeriodicalIF":1.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10767218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Annals of Rehabilitation Medicine-ARM
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