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Full-Structured or Supported by Incremental Scaffolds? Effects on Perceived Competence and Motivation 全结构支架还是增量支架?感知能力和动机的影响
4区 教育学 Q1 Social Sciences Pub Date : 2023-10-27 DOI: 10.1080/00220973.2023.2269128
Cornelia Stiller, Matthias Wilde
AbstractScientific inquiry is an inquiry-based learning approach that emphasizes student investigation of research questions and the utilization of scientific methods to address those research questions. One such method is experimentation, which is viewed as an open-ended problem-solving process that is mostly perceived by students as a complex procedure. Supplementing open inquiry with instructional support that matches students’ competences is crucial to enable autonomous experimentation. Incremental scaffolds offer instructional guidance during experimentation and allow students to work on a task autonomously. To answer the question of whether guidance through incremental scaffolds, as opposed to full-structured experimenting, might have a positive impact on students’ perceived competence regarding experimentation and motivation, 251 students were assigned to two treatment conditions in our study. The “full-structured group” (n = 122) worked with full-structured experimentation guides and the “incremental scaffolds group” (n = 129) received incremental scaffolds as supporting materials during experimentation. Our results show that the students in the “full-structured group” perceived themselves as significantly more competent in planning, conducting, and analyzing the experiment and were more intrinsically motivated than the students of the “incremental scaffolds group”.Keywords: Experimentationincremental scaffoldspromptsscientific inquiry AcknowledgmentsThe study was conducted in accordance with the legal requirements at the time of the conduction of the study. The principals of the school and the teachers of the participating classes were informed about the study and agreed to its implementation. There was no need for an ethical approval because no person-related data were collected.Disclosure statementNo potential conflict of interest was reported by the author(s).
摘要科学探究是一种以探究为基础的学习方式,强调学生对研究性问题进行调查,并运用科学方法解决这些研究问题。其中一种方法是实验,它被视为一个开放式的解决问题的过程,大多数学生认为这是一个复杂的过程。通过与学生能力相匹配的教学支持来补充开放式探究对于实现自主实验至关重要。增量式支架在实验过程中提供指导,并允许学生自主完成任务。为了回答是否通过增量式支架的指导,而不是完全结构化的实验,可能对学生在实验和动机方面的感知能力产生积极影响的问题,我们的研究将251名学生分配到两种治疗条件下。“全结构组”(n = 122)在实验过程中使用全结构实验指南,“增量支架组”(n = 129)在实验过程中使用增量支架作为支撑材料。我们的研究结果表明,“完整结构组”的学生认为自己在计划、执行和分析实验方面明显比“增量支架组”的学生更有能力,并且内在动机更强。关键词:实验增量支架提示科学探究致谢本研究在开展时符合法律要求。学校校长和参与班级的老师被告知了这项研究,并同意实施这项研究。由于没有收集与个人相关的数据,因此不需要伦理批准。披露声明作者未报告潜在的利益冲突。
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引用次数: 0
Same Classroom, Different Affordances? Demographic Differences in Perceptions of Motivational Climate in Five STEM Courses 同样的教室,不同的环境?五门STEM课程中动机气候感知的人口统计学差异
4区 教育学 Q1 Social Sciences Pub Date : 2023-10-21 DOI: 10.1080/00220973.2023.2267006
Kristy A. Robinson, So Yeon Lee
AbstractStudents vary in their perceptions of teachers’ motivational supports, even within the same classroom, but it is unclear why this is the case. To enable the design of equitable environments and understand the theoretical nature of motivational climate, this study explored demographic differences in university students’ perceptions of instruction across five large, introductory STEM (science, technology, engineering, and mathematics) courses (N = 2,486), along with end-of-semester outcomes. Results indicated that women and students from traditionally underrepresented racial or ethnic groups (Black, Hispanic/Latino/a, or Indigenous students) tended to perceive slightly higher motivational support in their courses compared to men and traditionally overrepresented (White or Asian) students, respectively. However, patterns were not uniform across all courses or variables. Men and women did not significantly differ on end-of-semester interest in any course, but women tended to have lower self-efficacy in some courses and significantly higher grades in programming compared to men. Implications include a caution for researchers against interpreting sample-specific or aggregated evidence of demographic differences as generalizing to broader populations or specific settings.Keywords: classroom environmentmotivational climateSTEM educationstudent perceptions Disclosure statementNo potential conflict of interest was reported by the authors.Notes1 Of the 2,486 students who consented to participate in the study, all but 3 completed at least one survey item used in the present study. The 3 students who consented but did not complete specific survey items (1 in General Chemistry, 2 in Calculus) were included in our analyses when possible to aid in full information maximum likelihood estimation, because their grades were still obtained from the instructors at the end of the semester (see missing data analyses below).2 We assume that this scale functioned poorly in our sample due to the lecture-style format of the courses. Although at least some of the course instructors typically use group discussions and activities when teaching in person, online instruction in 2020 introduced additional barriers to facilitating opportunities for students to interact with each other.3 To characterize descriptive statistics, we relied on guidelines developed by (Wormington and Linnenbrink-Garcia, Citation2017) and Linnenbrink-Garcia (2017), in which means are considered high if they are closer to the high end of the scale than to the midpoint (e.g., above 4 on a 5-point scale). A similar cutoff is used for characterizing means as low (e.g., below 2 on a 5-point scale). Values falling between these cutoffs are characterized as moderate when falling close to the midpoint of the scale or moderately high if falling more than halfway between the midpoint and the next higher increment (i.e., higher than 3.5 but lower than 4 on a 5-point scale).Additional informationFundingThe r
摘要即使在同一个教室里,学生对教师激励支持的看法也各不相同,但目前尚不清楚为什么会这样。为了设计公平的环境并理解动机气候的理论本质,本研究探讨了大学生对五门大型入门STEM(科学、技术、工程和数学)课程(N = 2,486)的教学感知的人口统计学差异,以及学期末的结果。结果表明,女性和来自传统上代表性不足的种族或族裔群体的学生(黑人、西班牙裔/拉丁裔/美洲裔或土著学生)在他们的课程中,分别比男性和传统上代表性过高的学生(白人或亚洲人)更容易感受到更高的激励支持。然而,模式并非在所有课程或变量中都是统一的。男性和女性在学期末对任何课程的兴趣上没有显著差异,但女性在某些课程上的自我效能感往往较低,而在编程方面的成绩则明显高于男性。影响包括对研究人员的警告,不要将特定样本或人口统计学差异的汇总证据解释为推广到更广泛的人群或特定环境。关键词:课堂环境动机气候系统教育学生认知披露声明作者未报告潜在的利益冲突。注1在2,486名同意参与研究的学生中,除3人外,其余学生均完成了至少一项用于本研究的调查项目。同意但没有完成具体调查项目的3名学生(1名普通化学,2名微积分)在可能的情况下被纳入我们的分析,以帮助充分的信息最大似然估计,因为他们的成绩仍然是在学期结束时从教师那里获得的(见下面的缺失数据分析)我们假设,由于课程的讲课式格式,该量表在我们的样本中功能不佳。尽管至少有一些课程教师在亲自授课时通常使用小组讨论和活动,但2020年的在线教学为促进学生相互交流带来了额外的障碍为了描述描述性统计的特征,我们依赖于(Wormington和Linnenbrink-Garcia, Citation2017)和Linnenbrink-Garcia(2017)制定的指导方针,其中如果平均值更接近于量表的高端而不是中点(例如,在5分制中高于4分),则认为平均值高。类似的截止值也用于表示平均数较低(例如,在5分制中低于2分)。落在这些截止点之间的值在接近中点时被描述为中等,如果落在中点和下一个更高的增量之间的一半以上,则被描述为中等高(即,在5分制中高于3.5但低于4)。本文所报道的研究得到了quimac基金会(FRQ;PI:冰斗)。内容完全是作者的责任,并不一定代表麦吉尔大学或FRQ的官方观点。
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引用次数: 0
Newton Makes Me Happy: Cycling Emotions during Science Text Reading 牛顿让我快乐:阅读科学文本时的情绪循环
4区 教育学 Q1 Social Sciences Pub Date : 2023-10-02 DOI: 10.1080/00220973.2023.2262814
Brian W. Miller
AbstractSome researchers have theorized that emotions while reading science texts influence learning in a wholistic way, such that overall positive or negative affect leads to different learning outcomes. Other researchers have envisioned that emotions fluctuate during reading such that the degree of cycling impacts the learning outcomes. In this study, participants read both expository and refutational science texts sentence-by-sentence. They described how each sentence made them feel and why. They completed the Force Concept Inventory before and after reading. The amount of positive emotions predicted conceptual growth for both types of texts. Students who tended to switch their emotions more often and had a variety of emotions also tended to learn more than other students. These results suggest that both types of theories could be true. An overall positive affect might be best, but the most effective students cycle through short periods of negative emotions as well.Keywords: emotionacademic emotionsscience educationscience readingemote-aloud AcknowledgmentsSpecial thanks to Dr. Cody Sandifer.Disclosure statementNo potential conflict of interest was reported by the author(s).Notes1 I am not including the most prominent theory in this field, the Control Value Theory of Academic Emotions (Pekrun & Perry, Citation2014), because it is not a theory of the interaction between emotions and learning but rather a theory explaining the antecedents of academic emotions.
摘要一些研究者认为,阅读科学文本时的情绪对学习的影响是整体性的,整体的积极或消极情绪会导致不同的学习结果。其他研究人员设想,在阅读过程中,情绪波动的程度会影响学习结果。在这项研究中,参与者逐句阅读说明性和反驳性的科学文本。他们描述了每个句子带给他们的感受以及原因。他们在阅读之前和之后都完成了“部队概念清单”。积极情绪的数量预测了两种类型文本的概念增长。情绪变化更频繁、情绪多变的学生也往往比其他学生学得更多。这些结果表明,这两种理论都可能是正确的。整体的积极影响可能是最好的,但最有效的学生也会在短时间的消极情绪中循环。关键词:情感学术情感科学教育科学阅读鸣谢特别感谢科迪·桑德弗博士披露声明作者未报告潜在的利益冲突。注1我没有包括这个领域最突出的理论——学术情绪控制价值理论(Pekrun & Perry, Citation2014),因为它不是一个关于情绪和学习之间相互作用的理论,而是一个解释学术情绪前因的理论。
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引用次数: 0
Working Memory and Automaticity in Relation to Mental Addition among American Elementary Students 美国小学生工作记忆和自动性与心理加法的关系
4区 教育学 Q1 Social Sciences Pub Date : 2023-09-26 DOI: 10.1080/00220973.2023.2261284
Qiong Yu, Yi Ding, Akane Zusho, Chun Zhang, Yifan Wang
AbstractThis study investigated the effects of working memory load (WML) and automaticity on mental addition through an examination of both task and individual characteristics within the framework of cognitive load theory. Seventy-three fourth-grade students in New York City public schools completed the Digit Span-Backward task of the Wechsler Intelligence Scale for Children-Fifth Edition, the Math Fluency subtest of the Wechsler Individual Achievement Test-Third Edition, and a 24-item computer-assisted addition task. Results showed that working memory load, automaticity, and their interaction had significant effects on mental addition. Automaticity had a differential effect on response time under low and high WML conditions. Results also showed that working memory, math fluency, and their interaction could predict a significant portion of variance in accuracy. However, math fluency was the only significant predictor for mental addition on the measure of response time. The study confirmed the interaction effect between working memory and automaticity and underscored the importance of automaticity in arithmetic learning.Keywords: American elementary studentsautomaticitymath fluencymental additionworking memory capacityworking memory load AcknowledgementsThis project was based on Qiong Yu’s dissertation study mentored by Yi Ding. Thanks to participating students.Ethical approvalThis study closely followed all ethical standards established by the Institutional Review Board (protocol #920).Disclosure statementNo potential conflict of interest was reported by the author(s).
摘要本研究在认知负荷理论的框架下,通过对任务特征和个体特征的考察,探讨了工作记忆负荷和自动性对心理加法的影响。纽约市公立学校的73名四年级学生完成了韦氏儿童智力量表(第五版)的数字跨度向后测验、韦氏个人成就测验(第三版)的数学流畅性子测验和一个24题的计算机辅助加法测验。结果表明,工作记忆负荷、自动性及其交互作用对心理加法有显著影响。在低WML和高WML条件下,自动性对反应时间有不同的影响。研究结果还表明,工作记忆、数学流畅性和它们之间的相互作用可以预测准确率的很大一部分差异。然而,在反应时间的测量中,数学流利度是唯一显著的预测因素。本研究证实了工作记忆与自动性之间的交互作用,并强调了自动性在算术学习中的重要性。关键词:美国小学生;自动性;数学流畅性;感谢参与的学生。伦理批准本研究严格遵循机构审查委员会制定的所有伦理标准(协议#920)。披露声明作者未报告潜在的利益冲突。
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引用次数: 0
Demographic, psychosocial, and medical correlates ofpsychological morbidity after intensive care unit stay. 入住重症监护室后心理发病率的人口、社会心理和医疗相关因素。
IF 2 4区 教育学 Q1 Social Sciences Pub Date : 2022-02-22 eCollection Date: 2022-01-01 DOI: 10.5114/hpr.2022.113515
George Zisopoulos, Pagona Roussi, Sousana Anisoglou

Background: Psychological morbidity [post-traumatic stress disorder (PTSD) symptoms, depressive, and anxiety symptoms] and a decline in health-related quality of life (HRQoL) are common after treatment in an intensive care unit (ICU). The aims of this article are: (a) to report psychological morbidity and HRQoL status three months after the ICU stay; (b) to report psychological morbidity correlates [demographic factors, social constraint (SC) regarding the ICU experience, negative ICU-related memories (NIM), and medical factors]; (c) to examine the hypothesis that SC would be a predictor of psychological morbidity after the ICU stay.

Participants and procedure: Seventy-two Greek patients filled in the following questionnaires: the Impact of Event Scale-Revised, the Hospital Anxiety and Depression Scale, the EuroQoL-5D-5L, and five questions regarding SC.

Results: In total, 47% of participants had symptoms of psychological morbidity at a moderate to high level and 94% reported that they had at least a problem regarding HRQoL. Predictors of PTSD symptoms were NIM, SC, female gender, and haloperidol dose. Predictors of anxiety symptoms were SC, the reporting of another stressor after the ICU stay, and low income. Predictors of depressive symptoms were SC, remifentanil dose (negative), and the reporting of another stressor.

Conclusions: Participants experienced elevated levels of psychological symptoms and SC emerged as a consistent predictor of psychological morbidity three months after the ICU stay.

背景:在重症监护室(ICU)接受治疗后,心理疾病(创伤后应激障碍(PTSD)症状、抑郁和焦虑症状)和健康相关生活质量(HRQoL)下降是常见现象。本文旨在(a) 报告入住重症监护室三个月后的心理发病率和 HRQoL 状况;(b) 报告心理发病率的相关因素[人口统计因素、与重症监护室经历相关的社会约束(SC)、与重症监护室相关的负面记忆(NIM)和医疗因素];(c) 研究 SC 可预测入住重症监护室后心理发病率的假设:72名希腊患者填写了以下问卷:事件影响量表(修订版)、医院焦虑和抑郁量表、EuroQoL-5D-5L以及五个有关SC的问题:结果:总共有 47% 的参与者有中度到高度的心理疾病症状,94% 的参与者表示至少在 HRQoL 方面存在问题。预测创伤后应激障碍症状的因素包括NIM、SC、女性性别和氟哌啶醇剂量。焦虑症状的预测因素是 SC、重症监护室住院后报告的另一个压力源和低收入。抑郁症状的预测因素是SC、瑞芬太尼剂量(阴性)和报告的另一个压力源:结论:参与者的心理症状水平升高,SC 是重症监护室住院三个月后心理发病率的一致预测因素。
{"title":"Demographic, psychosocial, and medical correlates ofpsychological morbidity after intensive care unit stay.","authors":"George Zisopoulos, Pagona Roussi, Sousana Anisoglou","doi":"10.5114/hpr.2022.113515","DOIUrl":"10.5114/hpr.2022.113515","url":null,"abstract":"<p><strong>Background: </strong>Psychological morbidity [post-traumatic stress disorder (PTSD) symptoms, depressive, and anxiety symptoms] and a decline in health-related quality of life (HRQoL) are common after treatment in an intensive care unit (ICU). The aims of this article are: (a) to report psychological morbidity and HRQoL status three months after the ICU stay; (b) to report psychological morbidity correlates [demographic factors, social constraint (SC) regarding the ICU experience, negative ICU-related memories (NIM), and medical factors]; (c) to examine the hypothesis that SC would be a predictor of psychological morbidity after the ICU stay.</p><p><strong>Participants and procedure: </strong>Seventy-two Greek patients filled in the following questionnaires: the Impact of Event Scale-Revised, the Hospital Anxiety and Depression Scale, the EuroQoL-5D-5L, and five questions regarding SC.</p><p><strong>Results: </strong>In total, 47% of participants had symptoms of psychological morbidity at a moderate to high level and 94% reported that they had at least a problem regarding HRQoL. Predictors of PTSD symptoms were NIM, SC, female gender, and haloperidol dose. Predictors of anxiety symptoms were SC, the reporting of another stressor after the ICU stay, and low income. Predictors of depressive symptoms were SC, remifentanil dose (negative), and the reporting of another stressor.</p><p><strong>Conclusions: </strong>Participants experienced elevated levels of psychological symptoms and SC emerged as a consistent predictor of psychological morbidity three months after the ICU stay.</p>","PeriodicalId":47911,"journal":{"name":"Journal of Experimental Education","volume":"44 1","pages":"191-202"},"PeriodicalIF":2.0,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80925634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gender Differences and Roles of Two Science Self-Efficacy Beliefs in Predicting Post-College Outcomes. 两种科学自我效能信念在预测大学毕业后成就中的性别差异及作用
IF 2.2 4区 教育学 Q1 Social Sciences Pub Date : 2022-01-01 DOI: 10.1080/00220973.2020.1808944
Kristy A Robinson, Tony Perez, Arianna White-Levatich, Lisa Linnenbrink-Garcia

The end of college is a key transition point when students prepare for the workforce or graduate school, and when competence beliefs that have been shaped throughout college play a particularly important role in decision-making processes. This study examined the roles of two competence beliefs, self-efficacy for scientific tasks and science academic self-efficacy, during the final year of college. A structural equation model was used to examine science research self-efficacy and science academic self-efficacy as predictors of post-graduation science career intentions and life satisfaction; prior achievement was also included as a predictor of competence beliefs and post-graduation outcomes. Findings indicated that both types of self-efficacy predicted career intentions and life satisfaction. To better understand the processes that contribute to gender gaps in certain science careers, gender differences in mean levels of self-efficacy and in the structural relations among the variables of interest were examined using multi-group analyses. Females reported lower academic self-efficacy, despite having similar levels of prior achievement and outcomes; structural relations also appeared to vary by gender. Results extend theoretical understanding of the roles of two distinct forms of self-efficacy and the potential mechanisms explaining gender gaps in science fields.

大学毕业是学生准备进入职场或读研的关键转折点,在大学期间形成的能力信念在决策过程中起着特别重要的作用。本研究考察了两种能力信念,即科学任务自我效能感和科学学术自我效能感在大学最后一年的作用。采用结构方程模型检验科研自我效能感和科学学术自我效能感对毕业后科学职业意向和生活满意度的影响;先前的成就也包括作为能力信念和毕业后结果的预测因子。研究结果表明,两种自我效能感都能预测职业意向和生活满意度。为了更好地理解在某些科学职业中造成性别差距的过程,我们使用多组分析检查了自我效能平均水平的性别差异以及感兴趣变量之间的结构关系。女性报告的学业自我效能较低,尽管她们之前的成就和结果水平相似;结构关系似乎也因性别而异。研究结果扩展了对两种不同形式的自我效能的理论理解,以及解释科学领域性别差距的潜在机制。
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引用次数: 14
Data Envelopment Analysis (DEA) in the Educational Sciences. 教育科学中的数据包络分析(DEA)。
IF 2.2 4区 教育学 Q1 Social Sciences Pub Date : 2022-01-01 Epub Date: 2021-04-09 DOI: 10.1080/00220973.2021.1906198
Jeffrey A Shero, Stephanie Al Otaiba, Chris Schatschneider, Sara A Hart

Many of the analytical models commonly used in educational research often aim to maximize explained variance and identify variable importance within models. These models are useful for understanding general ideas and trends, but give limited insight into the individuals within said models. Data envelopment analysis (DEA), is a method rooted in organizational management that makes such insights possible. Unlike models alluded to above, DEA does not explain variance. Instead, it explains how efficiently an individual utilizes their inputs to produce outputs, and identifies which input is not being utilized optimally. This paper provides a history and usages of DEA from fields outside of education, and describes the math and processes behind it. This paper then extends DEA's usage into the educational field using a study on child reading ability. Using students from the Project KIDS dataset (n=1987), DEA is demonstrated using a simple view of reading framework, identifying individual efficiency levels in using reading-based skills to achieve reading comprehension, determining which skills are being underutilized, and classifying new subsets of readers. New subsets of readers were identified using this method, with implications for more targeted interventions.

教育研究中常用的许多分析模型通常旨在最大限度地解释方差,并确定模型中变量的重要性。这些模型对于理解一般的想法和趋势很有用,但是对模型中的个体的了解有限。数据包络分析(DEA)是一种根植于组织管理的方法,它使这种见解成为可能。与上面提到的模型不同,DEA不解释方差。相反,它解释了个人如何有效地利用他们的投入来产生产出,并确定哪些投入没有得到最佳利用。本文从教育以外的领域提供了DEA的历史和用法,并描述了其背后的数学和过程。然后,本文通过对儿童阅读能力的研究,将DEA的应用扩展到教育领域。使用来自Project KIDS数据集的学生(n=1987),使用阅读框架的简单视图来演示DEA,确定使用基于阅读的技能来实现阅读理解的个人效率水平,确定哪些技能未被充分利用,并分类新的读者子集。使用这种方法确定了新的读者子集,这意味着更有针对性的干预措施。
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引用次数: 2
Impact of Hormonal Contraceptives on Cervical T-helper 17 Phenotype and Function in Adolescents: Results from a Randomized, Crossover Study Comparing Long-acting Injectable Norethisterone Oenanthate (NET-EN), Combined Oral Contraceptive Pills, and Combined Contraceptive Vaginal Rings. 激素避孕药对青少年宫颈 T-helper 17 表型和功能的影响:长效注射用炔诺酮(NET-EN)、复合口服避孕药和复合避孕阴道环的随机交叉研究结果。
4区 教育学 Q1 Social Sciences Pub Date : 2020-10-23 DOI: 10.1093/cid/ciz1063
Iyaloo N Konstantinus, Christina Balle, Shameem Z Jaumdally, Hoyam Galmieldien, Tanya Pidwell, Lindi Masson, Ramla F Tanko, Anna-Ursula Happel, Musalula Sinkala, Landon Myer, Steven E Bosinger, Katherine Gill, Linda-Gail Bekker, Heather B Jaspan, Jo-Ann S Passmore

Background: Adolescents in sub-Saharan Africa are at risk for human immunodeficiency virus (HIV) infection and unintended pregnancies. Observational studies suggest that injectable hormonal contraceptives (HCs) increase the HIV risk, although their effects on genital inflammation, particularly HIV-susceptible T-helper 17 (Th17) cells, are unknown. In a randomized crossover study, the effect of injectable norethisterone oenanthate (NET-EN), combined contraceptive vaginal rings (CCVR; NuvaRing), and combined oral contraceptive pills (COCPs) on cervical Th17 cells and cytokines were compared.

Methods: Adolescents (n = 130; 15-19 years) were randomly assigned 1:1:1 to NET-EN, CCVR, or COCPs for 16 weeks, then subsequently crossed over to another HC for 16 weeks. Estrogen, follicular stimulating hormone (FSH), and luteinizing hormone (LH) levels were measured. Chemokine receptor 5 (CCR5), human leukocyte antigen (HLA) DR isotope, and cluster of differentiation 38 (CD38) expression by cervical cytobrush-derived CD4+ T cells was assessed by fluorescence-activated cell sorting. Th17 cells were defined as CCR6+ and CCR10-. Cervicovaginal Th17-related cytokines were measured by Luminex.

Results: CCVR use for the first 16 weeks was associated with reduced Th17 frequencies and lower FSH and LH concentrations, as compared to NET-EN and COCPs, with FSH concentrations and Th17 frequencies correlating significantly. However, Th17-related cytokine concentrations (interleukin [IL]-21, IL-1β, tumor necrosis factor-α, interferon-γ) and CCR5, HLA-DR, CD38, and Th17 frequencies were significantly higher in CCVR than NET-EN and COCP. At crossover, CCVR users changing to COCPs or NET-EN did not resolve activation or cytokines, although switching from COCP to CCVRs increased cytokine concentrations.

Conclusions: CCVR use altered endogenous hormone levels and associated cervical Th17 cell frequencies to a greater extent than use of NET-EN or COCPs, although Th17 cells were more activated and Th17-related cytokine concentrations were elevated. While CCVRs may impact the HIV risk by regulating Th17 numbers, increased activation and inflammation may balance any risk gains.

背景:撒哈拉以南非洲地区的青少年面临感染人类免疫缺陷病毒(HIV)和意外怀孕的风险。观察性研究表明,注射用荷尔蒙避孕药(HCs)会增加感染 HIV 的风险,但它们对生殖器炎症,尤其是对 HIV 易感的 Thelper 17(Th17)细胞的影响尚不清楚。在一项随机交叉研究中,比较了注射用炔诺酮(NET-EN)、复方阴道避孕环(CCVR;NuvaRing)和复方口服避孕药(COCPs)对宫颈Th17细胞和细胞因子的影响:将青少年(n = 130;15-19 岁)以 1:1:1 的比例随机分配到 NET-EN、CCVR 或 COCPs,为期 16 周,然后交叉分配到另一种 HC,为期 16 周。测量雌激素、促卵泡激素(FSH)和促黄体生成素(LH)水平。通过荧光激活细胞分选法评估了宫颈细胞刷衍生的 CD4+ T 细胞的趋化因子受体 5 (CCR5)、人类白细胞抗原 (HLA) DR 同位素和分化簇 38 (CD38) 表达。Th17细胞被定义为CCR6+和CCR10-。宫颈阴道 Th17 相关细胞因子由 Luminex 测定:结果:与NET-EN和COCPs相比,前16周使用CCVR与Th17频率降低、FSH和LH浓度降低有关,其中FSH浓度与Th17频率显著相关。然而,CCVR 中与 Th17 相关的细胞因子浓度(白细胞介素 [IL]-21、IL-1β、肿瘤坏死因子-α、干扰素-γ)以及 CCR5、HLA-DR、CD38 和 Th17 频率明显高于 NET-EN 和 COCP。在交叉研究中,CCVR使用者改用COCPs或NET-EN并没有改变活化或细胞因子,但从COCPs改用CCVRs会增加细胞因子浓度:结论:与使用 NET-EN 或 COCPs 相比,使用 CCVR 在更大程度上改变了内源性激素水平和相关的宫颈 Th17 细胞频率,但 Th17 细胞的活化程度更高,与 Th17 相关的细胞因子浓度也升高了。虽然CCVR可能会通过调节Th17细胞的数量来影响艾滋病风险,但活化和炎症的增加可能会平衡风险的增加。
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引用次数: 0
Benefits of Playing Numerical Card Games on Head Start Children's Mathematical Skills. 玩数字卡片游戏对启蒙儿童数学技能的益处。
IF 2.2 4区 教育学 Q1 Social Sciences Pub Date : 2020-01-01 Epub Date: 2019-04-15 DOI: 10.1080/00220973.2019.1581721
Nicole R Scalise, Emily N Daubert, Geetha B Ramani

Low-income preschoolers have lower average performance on measures of early numerical skills than middle-income children. The present study examined the effectiveness of numerical card games in improving children's numerical and executive functioning skills. Low-income preschoolers (N=76) were randomly assigned to play a numerical magnitude comparison card game, a numerical memory and matching card game, or a shape and color matching card game across four 15-minute sessions. Child who played either of the numerical games improved their numeral identification skills, while only children who played the numerical magnitude comparison game improved their symbolic magnitude comparison skills. These improvements were maintained eight weeks later. The results suggest that a brief, low-cost intervention can successfully improve the numerical skills of low-income children.

与中等收入儿童相比,低收入学龄前儿童在早期运算技能方面的平均成绩较低。本研究考察了数字卡片游戏在提高儿童数字和执行功能技能方面的效果。低收入学龄前儿童(人数=76)被随机分配玩数字大小比较卡片游戏、数字记忆和配对卡片游戏或形状和颜色配对卡片游戏,共四次,每次 15 分钟。玩数字游戏的儿童提高了数字识别能力,而只有玩数字大小比较游戏的儿童提高了符号大小比较能力。这些进步在八周后得以保持。结果表明,简短、低成本的干预措施可以成功提高低收入儿童的数字技能。
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引用次数: 0
APOL1 gene variants and kidney disease in whites: the cardiovascular health study. APOL1 基因变异与白人肾病:心血管健康研究。
IF 6.1 4区 教育学 Q1 Social Sciences Pub Date : 2019-12-01 DOI: 10.1093/ndt/gfz186
Erika R Drury, David J Friedman, Martin R Pollak, Joachim H Ix, Lewis H Kuller, Russell P Tracy, Kenneth J Mukamal
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Journal of Experimental Education
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