Pub Date : 2024-01-15DOI: 10.18231/j.achr.2023.052
DR DHIRAJ B NIKUMBH
{"title":"Future trends in pathology:Artificial intelligence","authors":"DR DHIRAJ B NIKUMBH","doi":"10.18231/j.achr.2023.052","DOIUrl":"https://doi.org/10.18231/j.achr.2023.052","url":null,"abstract":"","PeriodicalId":479918,"journal":{"name":"IP archives of cytology and histopathology research","volume":"40 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139437203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-15DOI: 10.18231/j.achr.2023.053
S. Usman, Zoha Khan, R. Khan, N. Afroz, S. Harris
Intestine has wide spectrum of diseases comprising neoplastic and non-neoplastic lesions. Inflammatory bowel diseases are showing increasing trend and intestinal neoplasms are the most frequently observed and leading cause of death in India. This study aims to find the occurrence of various intestinal lesions, classify them as neoplastic and non-neoplastic and to correlate the histopathological findings with clinical profile of patient in tertiary care hospital of north India. 1129 biopsies and resection specimens of intestinal lesions were examined over a period of two years. Sections were fixed, paraffin embedded and stained by H&E. Immunohistochemistry was applied wherever required. Nearly two third patients were males in their second decade who presented with abdominal pain as the most common complaint and majority were diagnosed with non-neoplastic diseases. Among non-neoplastic lesions non-specific inflammation was predominant in small intestine (47.04% cases) and appendicitis (55.0%) in large intestine. Adenocarcinoma was predominant in both small and large intestine with 80.77% and79.45% of neoplastic cases respectively. This work gives a panoramic view of different intestinal pathologies and emphasises on the need of planning accurate diagnostic and screening strategies along with effective treatment plans both for neoplastic as well as non-neoplastic diseases.
{"title":"Spectrum of intestinal lesion: A clinicopathological study in a tertiary care centre","authors":"S. Usman, Zoha Khan, R. Khan, N. Afroz, S. Harris","doi":"10.18231/j.achr.2023.053","DOIUrl":"https://doi.org/10.18231/j.achr.2023.053","url":null,"abstract":"Intestine has wide spectrum of diseases comprising neoplastic and non-neoplastic lesions. Inflammatory bowel diseases are showing increasing trend and intestinal neoplasms are the most frequently observed and leading cause of death in India. This study aims to find the occurrence of various intestinal lesions, classify them as neoplastic and non-neoplastic and to correlate the histopathological findings with clinical profile of patient in tertiary care hospital of north India. 1129 biopsies and resection specimens of intestinal lesions were examined over a period of two years. Sections were fixed, paraffin embedded and stained by H&E. Immunohistochemistry was applied wherever required. Nearly two third patients were males in their second decade who presented with abdominal pain as the most common complaint and majority were diagnosed with non-neoplastic diseases. Among non-neoplastic lesions non-specific inflammation was predominant in small intestine (47.04% cases) and appendicitis (55.0%) in large intestine. Adenocarcinoma was predominant in both small and large intestine with 80.77% and79.45% of neoplastic cases respectively. This work gives a panoramic view of different intestinal pathologies and emphasises on the need of planning accurate diagnostic and screening strategies along with effective treatment plans both for neoplastic as well as non-neoplastic diseases.","PeriodicalId":479918,"journal":{"name":"IP archives of cytology and histopathology research","volume":"39 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139437268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-15DOI: 10.18231/j.achr.2023.064
Kafil Akhtar, Z. Hashmi, Sara Fatima Aslam, Adiba Khan
High grade serous ovarian cancer is the most common form of ovarian cancer which is frequently fatal, as it is commonly diagnosed after substantial metastasis has already occurred. The present study reports a 65 years old woman with postmenopausal bleeding for 3 months. CE-MRI revealed malignant right ovarian lesion with broad ligament fibroid with malignant degeneration. Histopathological examination was consistent with high grade serous carcinoma of right ovary. Patient then received 6 cycles of chemotherapy. After 4 months, she developed abdominal discomfort and backache for which a repeat CE-MRI was performed which showed a heterogeneity in the right adnexa with no markedly appreciable abnormal foci in the right ovary. Subsequently the patient underwent transabdominal hysterectomy with bilateral salpingo-oophorectomy with right hemicolectomy and omentectomy. Microscopic examination of intestine and omentum showed infiltration by tumor cells. A final diagnosis of metastatic high grade carcinoma of ovary with intestinal and omental deposits was given.
{"title":"Metastatic ovarian high grade serous carcinoma with intestinal and omental deposits and marked clinicopathological treatment response in right ovary: A rare case report","authors":"Kafil Akhtar, Z. Hashmi, Sara Fatima Aslam, Adiba Khan","doi":"10.18231/j.achr.2023.064","DOIUrl":"https://doi.org/10.18231/j.achr.2023.064","url":null,"abstract":"High grade serous ovarian cancer is the most common form of ovarian cancer which is frequently fatal, as it is commonly diagnosed after substantial metastasis has already occurred. The present study reports a 65 years old woman with postmenopausal bleeding for 3 months. CE-MRI revealed malignant right ovarian lesion with broad ligament fibroid with malignant degeneration. Histopathological examination was consistent with high grade serous carcinoma of right ovary. Patient then received 6 cycles of chemotherapy. After 4 months, she developed abdominal discomfort and backache for which a repeat CE-MRI was performed which showed a heterogeneity in the right adnexa with no markedly appreciable abnormal foci in the right ovary. Subsequently the patient underwent transabdominal hysterectomy with bilateral salpingo-oophorectomy with right hemicolectomy and omentectomy. Microscopic examination of intestine and omentum showed infiltration by tumor cells. A final diagnosis of metastatic high grade carcinoma of ovary with intestinal and omental deposits was given.","PeriodicalId":479918,"journal":{"name":"IP archives of cytology and histopathology research","volume":"48 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139437434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-15DOI: 10.18231/j.achr.2023.055
Priya Jayakumar, D. Chauhan
Solid papillary carcinoma (SPC) is considered a rare malignant breast tumor. This tumour can be either in situ or invasive .Both usually show excellent prognosis. Solid papillary carcinoma often shows neuroendocrine differentiation. 74-year-old lady an ulcerative retroareolar mass in the right breast. CECT Thorax revealed a large lobulated fungating ulceroproliferative mass lesion in the right breast with pectoral muscle involvement.without neuroendocrine differentiation. SPC with invasion is an uncommon variant of papillary carcinoma with frequent mucinous differentiation. Neuroendocrine differentiation although supports the diagnosis of solid papillary carcinoma may or may not be present.
{"title":"Invasive solid papillary breast carcinoma without neuroendocrine differentiation","authors":"Priya Jayakumar, D. Chauhan","doi":"10.18231/j.achr.2023.055","DOIUrl":"https://doi.org/10.18231/j.achr.2023.055","url":null,"abstract":"Solid papillary carcinoma (SPC) is considered a rare malignant breast tumor. This tumour can be either in situ or invasive .Both usually show excellent prognosis. Solid papillary carcinoma often shows neuroendocrine differentiation. 74-year-old lady an ulcerative retroareolar mass in the right breast. CECT Thorax revealed a large lobulated fungating ulceroproliferative mass lesion in the right breast with pectoral muscle involvement.without neuroendocrine differentiation. SPC with invasion is an uncommon variant of papillary carcinoma with frequent mucinous differentiation. Neuroendocrine differentiation although supports the diagnosis of solid papillary carcinoma may or may not be present.","PeriodicalId":479918,"journal":{"name":"IP archives of cytology and histopathology research","volume":"38 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139437273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-15DOI: 10.18231/j.achr.2023.058
J. Kalariya
This abstract presents a rare case of a huge renal oncocytoma, emphasizing its diagnostic challenges, clinical management, and unique characteristics. Oncocytomas are relatively uncommon benign neoplasms, typically found in various organs, including the kidneys, salivary glands, and thyroid. However, the occurrence of an exceptionally large renal oncocytoma poses distinct clinical considerations. We report the case of a patient who presented with a large palpable mass occupying almost whole abdomen with firm to hard in consistency. The diagnostic process involved an imaging studies, including computed tomography (CT) along with histopathological examination of specimen. The diagnostic challenges stemmed from the atypical size and radiological features. Surgical intervention was necessary due to the size of the renal oncocytoma. This case highlights the importance of considering renal oncocytomas in the differential diagnosis of large renal masses, even when their size exceeds typical dimensions. The management of huge oncocytomas involves a multidisciplinary approach, incorporating advanced imaging techniques, pathological assessment, and surgical expertise. Histology of renal oncocytoma in our case is also different as it is showing cystic areas. Immunohistochemistry confirmed the diagnosis of renal oncocytoma. Awareness of these rare cases is crucial for clinicians to guide appropriate diagnostic and therapeutic strategies, ensuring optimal patient outcomes.
{"title":"Huge renal oncocytoma with solid and cystic areas - A case report and review of literature","authors":"J. Kalariya","doi":"10.18231/j.achr.2023.058","DOIUrl":"https://doi.org/10.18231/j.achr.2023.058","url":null,"abstract":"This abstract presents a rare case of a huge renal oncocytoma, emphasizing its diagnostic challenges, clinical management, and unique characteristics. Oncocytomas are relatively uncommon benign neoplasms, typically found in various organs, including the kidneys, salivary glands, and thyroid. However, the occurrence of an exceptionally large renal oncocytoma poses distinct clinical considerations. We report the case of a patient who presented with a large palpable mass occupying almost whole abdomen with firm to hard in consistency. The diagnostic process involved an imaging studies, including computed tomography (CT) along with histopathological examination of specimen. The diagnostic challenges stemmed from the atypical size and radiological features. Surgical intervention was necessary due to the size of the renal oncocytoma. This case highlights the importance of considering renal oncocytomas in the differential diagnosis of large renal masses, even when their size exceeds typical dimensions. The management of huge oncocytomas involves a multidisciplinary approach, incorporating advanced imaging techniques, pathological assessment, and surgical expertise. Histology of renal oncocytoma in our case is also different as it is showing cystic areas. Immunohistochemistry confirmed the diagnosis of renal oncocytoma. Awareness of these rare cases is crucial for clinicians to guide appropriate diagnostic and therapeutic strategies, ensuring optimal patient outcomes.","PeriodicalId":479918,"journal":{"name":"IP archives of cytology and histopathology research","volume":"54 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139437177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-15DOI: 10.18231/j.achr.2023.063
Shashikala G. Hiremani, Renuka Patil, Aayesha, Srushti
Disease affecting Lymph nodes form wide range of spectrum from simple to malignant pathology. Such cases are an important element to rule out malignancy in early stages. However Generalised Lymphedenopathy diagnosis become huge challenge. Hence, an insight into clinocohistopathological correlation with help of IHC markers becomes highly important to decide morphologic differential diagnosis.: To study lymph node lesions with clinicohistopathological correlation with the help of IHC study. This is a combined observational and prospective study held in District hospital Vijayapur during August 2022 to September 2023. Patient details were taken with the questionnaires. During his first visit clinical examinations and investigations, CBC, PS study, FNAC of left lower cervical region, Urine routine, chest X-ray & USG of abdomen performed and patient was analyzed & diagnosed as Chronic appendicitis and treated. During patient’s second visit, clinical examinations and investigations CBC, PS study, FNAC of left Axillary swelling, Urine routine, chest X-ray, USG of neck & abdomen, CT Neck & abdomen, USG guided FNAC of Liver, Bone marrow aspiration study, Biopsy of left lower Cervical lymph node for Histopathology study & IHC study performed. Case was studied using routine H&E, PAP stain slides of Biopsy material were evaluated by light microscopy. And for IHC, patient biopsy material referred to higher center, using specific monoclonal or polyclonal antibodies, paraffin sections were stained immunohistochemically (IHC) using a Peroxidase antiperoxidase (PAP) technique in referred higher center. Patient was diagnosed as B-cell Lymphoma as per WHO guidelines with the help of IHC markers.: From this study, concluded that IHC plays a significant role clinicopathology and helped in the definitive diagnosis and typing of tumours and appropriate treatment can be planned.
{"title":"Role of immunohistochemistry in clinicohistopathology-A rare case study","authors":"Shashikala G. Hiremani, Renuka Patil, Aayesha, Srushti","doi":"10.18231/j.achr.2023.063","DOIUrl":"https://doi.org/10.18231/j.achr.2023.063","url":null,"abstract":"Disease affecting Lymph nodes form wide range of spectrum from simple to malignant pathology. Such cases are an important element to rule out malignancy in early stages. However Generalised Lymphedenopathy diagnosis become huge challenge. Hence, an insight into clinocohistopathological correlation with help of IHC markers becomes highly important to decide morphologic differential diagnosis.: To study lymph node lesions with clinicohistopathological correlation with the help of IHC study. This is a combined observational and prospective study held in District hospital Vijayapur during August 2022 to September 2023. Patient details were taken with the questionnaires. During his first visit clinical examinations and investigations, CBC, PS study, FNAC of left lower cervical region, Urine routine, chest X-ray & USG of abdomen performed and patient was analyzed & diagnosed as Chronic appendicitis and treated. During patient’s second visit, clinical examinations and investigations CBC, PS study, FNAC of left Axillary swelling, Urine routine, chest X-ray, USG of neck & abdomen, CT Neck & abdomen, USG guided FNAC of Liver, Bone marrow aspiration study, Biopsy of left lower Cervical lymph node for Histopathology study & IHC study performed. Case was studied using routine H&E, PAP stain slides of Biopsy material were evaluated by light microscopy. And for IHC, patient biopsy material referred to higher center, using specific monoclonal or polyclonal antibodies, paraffin sections were stained immunohistochemically (IHC) using a Peroxidase antiperoxidase (PAP) technique in referred higher center. Patient was diagnosed as B-cell Lymphoma as per WHO guidelines with the help of IHC markers.: From this study, concluded that IHC plays a significant role clinicopathology and helped in the definitive diagnosis and typing of tumours and appropriate treatment can be planned.","PeriodicalId":479918,"journal":{"name":"IP archives of cytology and histopathology research","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139437193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-15DOI: 10.18231/j.achr.2023.069
Iffat Jamal
{"title":"Hemophagocytic lymphohistiocytosis: An overview","authors":"Iffat Jamal","doi":"10.18231/j.achr.2023.069","DOIUrl":"https://doi.org/10.18231/j.achr.2023.069","url":null,"abstract":"","PeriodicalId":479918,"journal":{"name":"IP archives of cytology and histopathology research","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139437132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-15DOI: 10.18231/j.achr.2023.067
Kalpana Mangal, Alankrita Madhur, Ishita Bansal
Malignant melanoma is a prevalent form of skin cancer, but its occurrence as a sinonasal tumour is exceptionally uncommon, constituting less than 1% of nasal and sinonasal malignancies. Typically diagnosed in individuals aged 50 to 60, these tumours often manifest with symptoms such as nasal obstruction and recurrent, painless epistaxis. Despite their location, malignant melanoma cases generally have a bleak prognosis. Diagnosis primarily relies on Immunohistochemistry and histopathology.
{"title":"Sinonasal malignant melanoma- Diagnostically hidden Gem","authors":"Kalpana Mangal, Alankrita Madhur, Ishita Bansal","doi":"10.18231/j.achr.2023.067","DOIUrl":"https://doi.org/10.18231/j.achr.2023.067","url":null,"abstract":"Malignant melanoma is a prevalent form of skin cancer, but its occurrence as a sinonasal tumour is exceptionally uncommon, constituting less than 1% of nasal and sinonasal malignancies. Typically diagnosed in individuals aged 50 to 60, these tumours often manifest with symptoms such as nasal obstruction and recurrent, painless epistaxis. Despite their location, malignant melanoma cases generally have a bleak prognosis. Diagnosis primarily relies on Immunohistochemistry and histopathology.","PeriodicalId":479918,"journal":{"name":"IP archives of cytology and histopathology research","volume":"52 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139437250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-15DOI: 10.18231/j.achr.2023.065
Anjali D Goyal, Daksha Damor, Raj Shah, Foram Patel, Kajalba Jhala
Adenoid cystic carcinoma of breast is rare, accounting for less than 4% of all breast malignancy. We are presenting a case of 57 Year old Hindu female patient who presented with chief complaint of right breast swelling since 5 years associated with pain.USG report showed well defined isoechoic to hypoechoic lesion without internal vascularity, with a possibility of fibroadenoma of right breast. FNAC of the lesion was also suggestive of fibroadenoma. The wide local excision was done, tissue specimen was sent for histopathological examination which was diagnosed as adenoid cystic carcinoma of right breast after immunohistochemical characterization. Immunochemistry markers show ER, PR HER 2: negative, P -63: Positive for myoepithelial cells, Ki 67: <10%, CD 117/ c kit: Positive for ductal cells.
{"title":"Adenoid cystic carcinoma of breast: A rare case report","authors":"Anjali D Goyal, Daksha Damor, Raj Shah, Foram Patel, Kajalba Jhala","doi":"10.18231/j.achr.2023.065","DOIUrl":"https://doi.org/10.18231/j.achr.2023.065","url":null,"abstract":"Adenoid cystic carcinoma of breast is rare, accounting for less than 4% of all breast malignancy. We are presenting a case of 57 Year old Hindu female patient who presented with chief complaint of right breast swelling since 5 years associated with pain.USG report showed well defined isoechoic to hypoechoic lesion without internal vascularity, with a possibility of fibroadenoma of right breast. FNAC of the lesion was also suggestive of fibroadenoma. The wide local excision was done, tissue specimen was sent for histopathological examination which was diagnosed as adenoid cystic carcinoma of right breast after immunohistochemical characterization. Immunochemistry markers show ER, PR HER 2: negative, P -63: Positive for myoepithelial cells, Ki 67: <10%, CD 117/ c kit: Positive for ductal cells.","PeriodicalId":479918,"journal":{"name":"IP archives of cytology and histopathology research","volume":"53 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139437181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-15DOI: 10.18231/j.achr.2023.057
Anusha S, S. Bijjaragi, HR Chandrashekar, Veerendra Kumar HM
Hyalinizing Trabecular Tumour of the Thyroid (HTT) is a rare type of tumor that affects the thyroid gland. It was first discovered by Carney in 1987. This tumor is of follicular origin and has unique nuclear, architectural, and immunohistochemical features that differentiate it from other well-known thyroid abnormalities, such as Papillary Thyroid Carcinoma (PTC) and Medullary Thyroid Carcinoma (MTC). Although initially thought to be a subtype of PTC, several later reports showed that HTT is an independent entity. The incident rate of HTT ranges between 0.44% and 1.3%. This case report presents a 46-year-old male patient who complained of swelling in the front of his neck, more towards the left side, which had been observed for the past three months. FNAC (fine needle aspiration cytology) reported it as a follicular lesion of undetermined significance - Bethesda category III. Hemithyroidectomy was performed on the patient, and HTT was diagnosed through histopathological examination. As it is a benign neoplasm, PTC or other tumors had to be ruled out, and management varied accordingly. Based on its biological and clinical behavior, HTT should be considered as a benign neoplasm or as a neoplasm of extremely low malignant potential. This case report is presented for its unusual occurrence and unique behavior
{"title":"Hyalinizing trabecular tumor of thyroid (HTT) – A rare case report","authors":"Anusha S, S. Bijjaragi, HR Chandrashekar, Veerendra Kumar HM","doi":"10.18231/j.achr.2023.057","DOIUrl":"https://doi.org/10.18231/j.achr.2023.057","url":null,"abstract":"Hyalinizing Trabecular Tumour of the Thyroid (HTT) is a rare type of tumor that affects the thyroid gland. It was first discovered by Carney in 1987. This tumor is of follicular origin and has unique nuclear, architectural, and immunohistochemical features that differentiate it from other well-known thyroid abnormalities, such as Papillary Thyroid Carcinoma (PTC) and Medullary Thyroid Carcinoma (MTC). Although initially thought to be a subtype of PTC, several later reports showed that HTT is an independent entity. The incident rate of HTT ranges between 0.44% and 1.3%. This case report presents a 46-year-old male patient who complained of swelling in the front of his neck, more towards the left side, which had been observed for the past three months. FNAC (fine needle aspiration cytology) reported it as a follicular lesion of undetermined significance - Bethesda category III. Hemithyroidectomy was performed on the patient, and HTT was diagnosed through histopathological examination. As it is a benign neoplasm, PTC or other tumors had to be ruled out, and management varied accordingly. Based on its biological and clinical behavior, HTT should be considered as a benign neoplasm or as a neoplasm of extremely low malignant potential. This case report is presented for its unusual occurrence and unique behavior","PeriodicalId":479918,"journal":{"name":"IP archives of cytology and histopathology research","volume":"49 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139437388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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