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Critical limb ischemia leading to amputation as a presentation of acquired hemophilia A with congenital factor XII deficiency: a case report. 重度肢体缺血导致截肢,表现为获得性血友病a伴先天性因子12缺乏:1例报告。
IF 0.7 Q4 SURGERY Pub Date : 2025-11-01 Epub Date: 2025-10-15 DOI: 10.1016/j.ijscr.2025.112064
Lam Van Nut, Duong Dinh Bao, Bui Le Cuong, Nguyen Van Quang

Introduction and importance: Acquired Hemophilia A (AHA) is a rare autoimmune bleeding disorder caused by autoantibodies against factor VIII. Diagnosis is often delayed when confounding factors coexist.

Presentation of case: We report a 70-year-old male with peripheral arterial disease presenting with critical limb ischemia, severe anemia, and prolonged APTT. Investigations revealed factor VIII inhibitor, concomitant factor XII deficiency, and lupus anticoagulant positivity.

Clinical discussion: The combination of FXII deficiency and lupus anticoagulant created significant diagnostic confusion, as both are associated with prolonged APTT but not with bleeding. This overlap risked masking the hemorrhagic tendency of AHA. Management required bypassing agents, surgery, immunosuppressive therapy with corticosteroids and rituximab, and multidisciplinary care.

Conclusion: This case highlights the importance of considering acquired hemophilia A in unexplained bleeding with prolonged APTT, especially when coexisting conditions such as FXII deficiency and lupus anticoagulant may obscure diagnosis.

简介及重要性:获得性血友病A (AHA)是一种罕见的由抗因子VIII自身抗体引起的自身免疫性出血性疾病。当混杂因素共存时,诊断往往会延迟。病例介绍:我们报告一位70岁男性外周动脉疾病,表现为严重肢体缺血、严重贫血和APTT延长。调查显示因子VIII抑制剂,伴随因子XII缺乏,狼疮抗凝血阳性。临床讨论:FXII缺乏症和狼疮抗凝剂的联合使用造成了严重的诊断混乱,因为两者都与APTT延长有关,但与出血无关。这种重叠有可能掩盖AHA的出血倾向。治疗需要旁路药物、手术、皮质类固醇和利妥昔单抗的免疫抑制治疗以及多学科治疗。结论:该病例强调了在APTT延长的不明原因出血中考虑获得性血友病A的重要性,特别是当同时存在FXII缺乏和狼疮抗凝剂可能使诊断模糊不清时。
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引用次数: 0
Obturator hernia mimicking recurrent femoral hernia: A diagnostic challenge in an elderly patient (case report). 闭孔疝模拟复发性股疝:一个老年患者的诊断挑战(病例报告)。
IF 0.7 Q4 SURGERY Pub Date : 2025-11-01 Epub Date: 2025-10-20 DOI: 10.1016/j.ijscr.2025.112079
Boubker Idrissi Kaitouni, Fernando Nantote, Stephane Ayee, Zaynab Bellamlik, Mbarek Yaka

Introduction: Obturator hernia is a rare cause of bowel obstruction, predominantly affecting elderly women. Its non-specific symptoms often delay diagnosis, increasing the risk of complications.

Case presentation: We report the case of an 86-year-old woman presenting with signs of intestinal obstruction. CT imaging identified a strangulated right obturator hernia without ischemia, managed successfully via laparotomy. This case report has been reported in line with the SCARE 2025 checklist (Kerwan et al., 2025 [1]).

Discussion: While laparoscopy is increasingly used in selected cases, open surgery remains appropriate in emergencies or when technical conditions are unfavorable. Our decision for laparotomy was guided by marked bowel distension and respiratory constraints.

Conclusion: This case highlights the diagnostic challenge of obturator hernia, particularly in elderly patients with prior hernia history, where atypical presentations may mimic other conditions. Tailored surgical strategies, guided by clinical and intraoperative findings, are essential to optimize outcomes in such high-risk cases.

简介:闭孔疝是一种罕见的肠梗阻原因,主要影响老年妇女。其非特异性症状往往延误诊断,增加并发症的风险。病例介绍:我们报告的情况下,86岁的妇女表现出肠梗阻的迹象。CT影像发现无缺血的绞窄性右闭孔疝,通过剖腹手术成功处理。该病例报告符合SCARE 2025检查表(Kerwan et al., 2025[1])。讨论:虽然腹腔镜在特定病例中的应用越来越多,但在紧急情况或技术条件不利时,开放手术仍然是合适的。我们的决定是在明显的肠膨胀和呼吸限制的指导下进行剖腹手术。结论:该病例强调了闭孔疝的诊断挑战,特别是在有既往疝史的老年患者中,其不典型表现可能模仿其他疾病。在临床和术中发现的指导下,量身定制的手术策略对于优化此类高危病例的预后至关重要。
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引用次数: 0
Giant inguinal hernia, a case series. 巨大腹股沟疝1例。
IF 0.7 Q4 SURGERY Pub Date : 2025-11-01 Epub Date: 2025-10-10 DOI: 10.1016/j.ijscr.2025.112040
Anupam K Gupta

Introduction and importance: Inguinal hernia surgery is common worldwide. A giant inguinal hernia occurs when the hernia extends below the midpoint of the thigh, making reduction into the abdominal cavity challenging and posing significant operative and postoperative risks.

Case presentation: We report a case series of five male patients, aged 51-75 years, with giant inguinal hernias treated between January 2024 and January 2025. Four patients presented electively and one emergently with strangulation. All hernias extended below the midpoint of the thigh. Open surgical repair was performed in all cases, with reduction via an abdominal incision above the inguinal crease. The hernia contents included small and large bowel loops with omentum. In one case, the inferior epigastric artery was ligated to facilitate reduction.

Clinical discussion: We report a case series of five male patients, aged 51-75 years, with giant inguinal hernias treated between January 2024 and January 2025. Four patients presented electively and one emergently with strangulation. All hernias extended below the midpoint of the thigh. Open surgical repair was performed in all cases, with reduction via an abdominal incision above the inguinal crease. The hernia contents included small and large bowel loops with omentum. In one case, the inferior epigastric artery was ligated to facilitate reduction.

Conclusion: Giant inguinal hernias require individualized surgical planning. Careful reduction, sac excision, and reinforcement with mesh can achieve good outcomes. Ligation of the inferior epigastric artery may aid reduction in specific cases. A better understanding of socioclinical factors leading to delayed presentation may improve earlier detection and intervention.

腹股沟疝手术在世界范围内是很常见的。当疝延伸到大腿中点以下时,就会发生巨大的腹股沟疝,这使得进入腹腔的复位具有挑战性,并带来重大的手术和术后风险。病例介绍:我们报告了5例男性患者的病例系列,年龄51-75岁,在2024年1月至2025年1月期间治疗了巨大的腹股沟疝。四名患者选择性出现,一名紧急出现勒死。所有疝气都延伸到大腿中点以下。所有病例均行开放手术修复,通过腹股沟折痕上方的腹部切口复位。疝内容物包括带网膜的小肠袢和大肠袢。在一个病例中,腹壁下动脉被结扎以促进复位。临床讨论:我们报告了5例男性患者的病例系列,年龄51-75岁,在2024年1月至2025年1月期间治疗了巨大的腹股沟疝。四名患者选择性出现,一名紧急出现勒死。所有疝气都延伸到大腿中点以下。所有病例均行开放手术修复,通过腹股沟折痕上方的腹部切口复位。疝内容物包括带网膜的小肠袢和大肠袢。在一个病例中,腹壁下动脉被结扎以促进复位。结论:腹股沟巨大疝需要个体化的手术方案。仔细的复位、囊切除和补片加固可获得良好的效果。结扎腹壁下动脉可能有助于在特定情况下减少。更好地了解导致延迟表现的社会临床因素可以改善早期发现和干预。
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引用次数: 0
When the parasite strikes back: Secondary paraspinal hydatidosis: A case report. 当寄生虫反击:继发性棘旁包虫病:1例报告。
IF 0.7 Q4 SURGERY Pub Date : 2025-11-01 Epub Date: 2025-10-16 DOI: 10.1016/j.ijscr.2025.112075
Faten Limaiem, Mouadh Nefiss, Anis Bousrih, Ramzi Bouzidi

Introduction and importance: Hydatid disease predominantly involves the liver and lungs, whereas intramuscular localization is exceedingly rare, particularly in the paraspinal region.

Case presentation: A 57-year-old man with surgically treated pulmonary and retroperitoneal hydatid cysts in childhood presented with chronic thoracolumbar and left intercostal radicular pain. Imaging showed a multiloculated cystic lesion in the left paravertebral muscles at D11-D12 and D12-L1 with extension into the corresponding neural foramina. He underwent surgical excision and histopathology confirmed Echinococcus granulosus infection. Postoperative management included albendazole therapy. At 18 months, MRI showed no recurrence, and the patient was asymptomatic with no radiologic disease. Given the risk of late relapse, long-term follow-up is planned.

Clinical discussion: Muscular hydatidosis can present long after treated visceral disease. Diagnosis depends on clinical suspicion supported by serology and imaging, particularly in endemic regions. Definitive management is meticulous surgical excision with adjunctive antihelminthic therapy to minimize recurrence. Because primary muscular involvement is rare, misdiagnosis is common, necessitating heightened clinical vigilance. In our case, no recurrence was detected at 18 months. However, late relapse remains possible, warranting vigilant long-term surveillance with periodic imaging.

Conclusion: Hydatid disease should be included in the differential for paravertebral masses, even after treated visceral disease. This case highlights the need for long-term surveillance and a multidisciplinary approach. Early recognition and appropriate therapy are essential to prevent complications and recurrence.

简介和重要性:包虫病主要累及肝脏和肺部,而肌肉内定位极为罕见,特别是在棘旁区域。病例介绍:一名57岁男性,儿童期手术治疗肺和腹膜后包虫囊肿,表现为慢性胸腰椎和左肋间神经根性疼痛。影像学显示左侧椎旁肌D11-D12和D12-L1多室囊性病变,并延伸至相应的神经孔。他接受了手术切除和组织病理学证实颗粒棘球蚴感染。术后治疗包括阿苯达唑治疗。18个月时,MRI未显示复发,患者无症状,无影像学疾病。考虑到晚期复发的风险,计划进行长期随访。临床讨论:肌包虫病可在内脏疾病治疗后长期出现。诊断依赖于血清学和影像学支持的临床怀疑,特别是在流行地区。最终的治疗是精细的手术切除和辅助的抗寄生虫治疗,以尽量减少复发。由于原发性肌肉受累是罕见的,误诊是常见的,需要提高临床警惕。在本病例中,18个月后未发现复发。然而,晚期复发仍然是可能的,需要长期警惕地进行定期影像学检查。结论:棘旁肿物的鉴别应包括包虫病,即使已治疗过内脏疾病。这一病例突出了长期监测和多学科方法的必要性。早期识别和适当治疗是预防并发症和复发的关键。
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引用次数: 0
A case report of an unusual presentation of chyle leak after repair of a perforated gastric ulcer. 胃溃疡穿孔修复后不寻常的乳糜漏一例报告。
IF 0.7 Q4 SURGERY Pub Date : 2025-11-01 Epub Date: 2025-10-20 DOI: 10.1016/j.ijscr.2025.112084
Muhammed Isa Bin Jusoff Albar, Han Boon Oh

Introduction and importance: Chyle leak is an uncommon complication of abdominal surgeries. There are no reported cases of a chyle leakage following an omental patch repair for a perforated gastric ulcer before. A chyle leak from such a case however can successfully be treated conservatively.

Case presentation: We report an unusual case of a 57-year-old male presented with a perforated gastric ulcer who underwent a laparotomy and omental patch repair, which subsequently presented with a chyle leak from his abdominal wound.

Clinical discussion: Post operative chyle leak usually occurs from the intraoperative disruption of the thoracic duct, cisterna chyli, or major tributaries of the lymphatic system, and hence can also occur following abdominal and retroperitoneal surgeries. Chyle leakage is not one of the known postoperative complications following an omental patch repair. As chyle leak after omental patch repair has not been reported before, we sought to ascertain the causes. This case was successfully treated conservatively. This patient had a low volume chyle leak. The main stay of conservative treatment for a low volume chyle leak is to reduce chyle production via nutrition optimisation. Literature found that a more conservative approach to management of a chyle leak can be very successful. We discuss the conservative management of the chyle leak with intraabdominal drainage and a very low-fat diet.

Conclusion: A chyle leak following an omental patch repair for a perforated gastric ulcer is an unusual post-operative complication. It can be treated conservatively successfully provided the chyle leak maintains at a low volume.

简介及重要性:乳糜漏是腹部手术中一种罕见的并发症。以前没有报道过胃溃疡穿孔行网膜补片修补后乳糜漏的病例。然而,这种情况下的乳糜漏可以成功地保守治疗。病例介绍:我们报告一个不寻常的病例,一个57岁的男性胃溃疡穿孔,他接受了剖腹手术和网膜修补,随后出现了乳糜漏从他的腹部伤口。临床讨论:术后乳糜漏通常发生于术中胸导管、乳糜池或淋巴系统主要分支的破坏,因此也可发生于腹部和腹膜后手术。乳糜漏并不是大网膜补片修复术后已知的并发症之一。由于以前没有报道过网膜补片修补后乳糜漏,我们试图确定原因。保守治疗成功。这个病人有小体积的乳糜漏。保守治疗低体积乳糜漏的主要停留是通过营养优化减少乳糜生产。文献发现,更保守的方法来管理乳糜漏可以非常成功。我们讨论腹腔内引流和低脂饮食对乳糜漏的保守治疗。结论:胃溃疡穿孔行大网膜补片修补术后乳糜漏是一种罕见的术后并发症。只要乳糜漏保持在低体积,保守治疗即可成功。
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引用次数: 0
Postoperative opacification of intraocular lens: A case report. 术后人工晶状体混浊1例。
IF 0.7 Q4 SURGERY Pub Date : 2025-11-01 Epub Date: 2025-10-16 DOI: 10.1016/j.ijscr.2025.112076
Qihang Lei, Xiangli Wang, Qin Liu

Introduction and importance: This case report describes a rare complication of intraocular lens (IOL) opacification in a 76-year-old female patient after age-related cataract surgery in the right eye. Although uncommon, IOL clouding can significantly impair postoperative visual acuity, necessitating surgical intervention. Therefore, choosing the right type of artificial crystal is extremely important.

Case presentation: The patient presented with progressive blurred vision in the right eye for one year. We confirmed the diagnosis and identified the underlying cause after thoroughly excluding other potential influencing factors and make a distinction from congenital cataracts. Subsequently, surgical intervention was performed on the right eye, involving removal of IOL and the re-implantation of new IOL. It resulted in significant improvement in the patient's postoperative vision.

Clinical discussion: Clouding of the IOL following cataract surgery is characterized by a reduction in lens transparency after implantation. Although relatively uncommon, this complication can significantly impair vision. The etiology of IOL opacification post-surgery primarily encompasses material-related factors, surgical factors, patient-specific factors, and other miscellaneous factors. This case underscores the critical importance of evidence-based IOL selection in cataract surgery to mitigate vision-compromising postoperative complications.

Conclusion: With the advancement of surgical techniques and the introduction of new materials, the incidence of IOL opacification following cataract surgery has significantly decreased. Looking ahead, we will prioritize the use of hydrophobic acrylic IOLs or novel anti-calcification IOLs in future surgeries. This strategic choice aims to further minimize the impact of long-term complications on visual acuity post-cataract surgery.

简介及重要性:本病例报告描述了一位76岁女性患者在右眼年龄相关性白内障手术后发生人工晶状体混浊的罕见并发症。虽然不常见,但人工晶状体混浊会严重损害术后视力,需要手术干预。因此,选择合适类型的人造晶体是极其重要的。病例介绍:患者表现为右眼进行性视力模糊一年。我们在彻底排除其他可能的影响因素,并与先天性白内障进行区分后,确诊并明确病因。随后,对右眼进行手术干预,包括取出IOL和重新植入新的IOL。术后患者的视力得到了显著改善。临床讨论:白内障手术后人工晶状体混浊的特征是晶状体植入后透明度降低。虽然相对不常见,但这种并发症会严重损害视力。人工晶状体术后混浊的病因主要包括材料相关因素、手术因素、患者特异性因素和其他杂项因素。本病例强调了在白内障手术中选择基于证据的人工晶状体以减轻术后视力损害并发症的重要性。结论:随着手术技术的进步和新材料的引入,白内障术后人工晶状体混浊的发生率明显降低。展望未来,我们将在未来的手术中优先使用疏水性丙烯酸人工晶体或新型抗钙化人工晶体。这一战略选择旨在进一步减少白内障手术后长期并发症对视力的影响。
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引用次数: 0
A rare coincidence of intrarenal Wilms tumor with spina bifida: a case report and review of the literature. 肾内肾母细胞瘤合并脊柱裂的罕见病例报告及文献复习。
IF 0.7 Q4 SURGERY Pub Date : 2025-11-01 Epub Date: 2025-10-15 DOI: 10.1016/j.ijscr.2025.112043
Abay Gosaye, Wassie Almaw Yigzaw

Introduction: Children with congenital anomalies are at increased risk of childhood malignancies. Among these, children with nervous system and urinary system anomalies have the highest incidence rate of cancer. This is a report of an intrarenal Wilm's tumor in a patient with spina bifida.

Case presentation: A 4-month-old male baby with a repaired lumbosacral myelomeningocele presented with right flank swelling. At presentation, a firm, slightly mobile, and nontender right flank mass was noted. Abdominopelvic ultrasound performed at a neonatal age revealed an 8 mm right renal cyst at the lower pole without septa or mural nodules. Magnetic resonance imaging performed at his recent presentation was suggestive of Wilm's tumor. The histopathology revealed cystic, partially differentiated nephroblastoma with negative lymph nodes. It's a SIOP stage 1 low-risk tumor that doesn't deserve adjuvant chemoradiotherapy. He has been on follow-up for over a year, and no evidence of local recurrence or metastatic growth.

Discussion: Wilms' tumor is the commonest renal tumor of childhood, commonly seen in preschool children. Though it usually happens sporadically, some chromosomal anomalies are known to be associated with it. Patients with congenital anomalies, including spina bifida, are known to have an increased risk of Wilm's tumor. Hence, they need a thorough investigation whenever a visceral lesion is found incidentally, even if they are asymptomatic.

Conclusion: An intrarenal Wilms tumor can appear synchronously with spina bifida, and a high index of suspicion should be maintained to rule out malignancy when we encounter a young patient with spinal dysraphism and a visceral lesion.

导读:患有先天性畸形的儿童患儿童恶性肿瘤的风险增加。其中,神经系统和泌尿系统异常的儿童癌症发病率最高。本文报告一例脊柱裂患者的肾内Wilm肿瘤。病例介绍:一个4个月大的男婴与修复的腰骶髓脊膜膨出表现为右侧肿胀。就诊时,发现右侧有坚硬、轻微移动、无压痛的肿块。新生儿时进行的盆腔超声检查显示右下极有一个8毫米的肾囊肿,无间隔或壁结节。在他最近的报告中进行的磁共振成像显示了威尔姆的肿瘤。组织病理学显示为囊性,部分分化肾母细胞瘤,淋巴结阴性。这是SIOP期低危肿瘤不需要辅助放化疗。他已经随访了一年多,没有局部复发或转移性生长的迹象。讨论:肾母细胞瘤是儿童期最常见的肾脏肿瘤,常见于学龄前儿童。虽然它通常偶尔发生,但已知一些染色体异常与它有关。患有先天性畸形的患者,包括脊柱裂,患威尔姆氏瘤的风险增加。因此,只要偶然发现内脏病变,即使没有症状,也需要彻底检查。结论:肾内Wilms肿瘤可与脊柱裂同时出现,当我们遇到年轻的脊柱发育异常和内脏病变时,应保持高度的怀疑,以排除恶性肿瘤。
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引用次数: 0
Conservative treatment of ameloblastic fibroma a case report with review of literature. 成釉细胞纤维瘤的保守治疗1例并文献复习。
IF 0.7 Q4 SURGERY Pub Date : 2025-11-01 Epub Date: 2025-10-14 DOI: 10.1016/j.ijscr.2025.112048
Gerardo Bardales Arguelles, Francisco Díaz Ayala, Claudette Marcelle Arambú Turcios, Gustavo Alberto Sierra Larios, Hugo Romero Alvarenga, Juan José Guifarro Sierra

Introduction and importance: Ameloblastic fibroma (AF) is a benign mixed odontogenic tumor composed of epithelial and mesenchymal tissues. It accounts for approximately 1.5-4.5 % of all odontogenic tumors and is most commonly diagnosed during the first and second decades of life. Due to documented cases of malignant transformation, the optimal therapeutic approach for AF remains a subject of debate.

Case presentation: A 15-year-old female patient presented with pain, swelling, and purulent discharge in the right posterior mandible. Panoramic radiography revealed a unilocular radiolucent lesion associated with tooth 48. The patient had no significant medical history.

Clinical discussion: An incisional biopsy was performed with the presumptive diagnosis of odontogenic keratocyst, followed by decompression tube placement. Histopathological examination confirmed the diagnosis of ameloblastic fibroma. Given the patient's age and the low likelihood of malignant transformation, a conservative treatment approach was adopted, consisting of enucleation, curettage, peripheral osteotomy, and extraction of retained teeth. Due to the compromised lingual and vestibular cortices at the mandibular basal border-observed on computed tomography (CT)-a reconstruction plate was placed to prevent pathological fracture.

Conclusion: AF is a rare, often asymptomatic odontogenic tumor. Therapeutic management remains controversial due to its recurrence rate (18.3 %-43.5 %) and potential for malignant transformation (reported in one-third of cases). In this case, at the 9-month follow-up, the patient exhibited preserved mandibular function, remained asymptomatic, and showed no clinical or radiographic evidence of recurrence. Conservative treatment with rigorous long-term monitoring may be the preferred approach for young patients to optimize functional outcomes and quality of life. No generative artificial intelligence (AI) tools were used in the conception, design, data collection, analysis, or interpretation of the research presented in this manuscript. Furthermore, no AI-assisted technologies were employed in the drafting, editing, or revision of the manuscript.

成釉细胞纤维瘤(AF)是一种由上皮组织和间充质组织组成的良性混合牙源性肿瘤。它约占所有牙源性肿瘤的1.5- 4.5%,最常见于生命的第一和第二个十年。由于记录的病例恶性转化,最佳治疗方法的房颤仍然是一个主题的争论。病例介绍:一名15岁的女性患者,表现为右侧后下颌骨疼痛、肿胀和脓性分泌物。全景x线摄影显示48号牙有一单眼透光病变。患者无明显病史。临床讨论:进行切口活检,推定诊断为牙源性角化囊肿,随后放置减压管。组织病理学检查证实为成釉细胞纤维瘤。考虑到患者的年龄和恶性转化的可能性较低,我们采取保守治疗方法,包括去核、刮除、周围截骨、拔除保留牙。由于下颌基底缘舌皮质和前庭皮质受损(CT),因此放置重建钢板以防止病理性骨折。结论:房颤是一种罕见的、通常无症状的牙源性肿瘤。由于其复发率(18.3% - 43.5%)和恶性转化的可能性(报告在三分之一的病例中),治疗管理仍然存在争议。在此病例中,在9个月的随访中,患者表现出保留的下颌功能,仍然无症状,并且没有显示复发的临床或影像学证据。保守治疗和严格的长期监测可能是年轻患者优化功能结局和生活质量的首选方法。在本文中提出的研究的构思、设计、数据收集、分析或解释中没有使用生成式人工智能(AI)工具。此外,在手稿的起草、编辑或修订中没有使用人工智能辅助技术。
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引用次数: 0
Invasive mole after heterotopic pregnancy in a postmenopausal woman: A rare case report from a tertiary hospital in northern Tanzania. 绝经后妇女异位妊娠后侵袭性痣:坦桑尼亚北部一家三级医院的罕见病例报告。
IF 0.7 Q4 SURGERY Pub Date : 2025-11-01 Epub Date: 2025-10-16 DOI: 10.1016/j.ijscr.2025.112069
John Lugata, Glory Maringo, Tecla Lyamuya, Eusebious Maro, Joseph Mlay, Alex Mremi

Introduction and importance: Invasive moles (IMs) are a rare form of gestational trophoblastic disease (GTD) characterized by molar tissue made up of hydropic villi with an overgrowth of trophoblastic cells. These can penetrate the myometrium or uterine vessels in women of reproductive age. Its occurrence in postmenopausal women is exceedingly rare, and even more unusual when arising after a heterotopic pregnancy. Such presentations pose significant diagnostic and therapeutic dilemmas, particularly in resource-limited settings where access to advanced diagnostics and oncology services may be constrained.

Case presentation: We report a rare case of invasive mole in a 48-year-old woman, 3 years postmenopausal, from Northern Tanzania. She presented to our tertiary hospital with a 3-month history of lower abdominal pain, abdominal distension, and per vaginal bleeding. The patient had a prior history of molar evacuation and left salpingectomy for a heterotopic ectopic pregnancy. Post-evacuation, she did not undergo serial monitoring of serum β-hCG levels. Abdominal ultrasonography revealed a bulky uterus with a heterogeneous, myometrium-infiltrating mass, raising suspicion of uterine choriocarcinoma. In view of the findings and clinical condition, a total abdominal hysterectomy was performed. Histopathological examination confirmed an invasive mole, stage I, with a FIGO prognostic score of 7. Despite counseling, the patient declined adjuvant chemotherapy.

Clinical discussion: In this rare case report, we discuss the rarity of invasive mole in a postmenopausal woman after heterotopic pregnancy and underscores the importance of β-hCG surveillance for early detection.

Conclusion: This case highlights the diagnostic and therapeutic challenges of invasive mole in a postmenopausal woman after heterotopic pregnancy in a resource-limited setting. The absence of post-evacuation β-hCG surveillance contributed to delayed recognition. Clinicians should maintain a high index of suspicion and emphasize the importance of hCG monitoring for early detection and optimal management of GTN. Also should maintain a high index of suspicion for GTN in women with abnormal bleeding even after menopause.

简介及重要性:侵袭性痣(IMs)是一种罕见的妊娠滋养层疾病(GTD),其特征是磨牙组织由疏水绒毛组成,滋养层细胞过度生长。它们可以穿透育龄妇女的子宫肌层或子宫血管。它发生在绝经后的妇女是非常罕见的,更不寻常的是发生在异位妊娠后。这种表现造成了重大的诊断和治疗困境,特别是在资源有限的环境中,获得先进的诊断和肿瘤服务可能受到限制。病例介绍:我们报告一例罕见的侵袭性痣的48岁妇女,绝经后3年,从坦桑尼亚北部。她以3个月的下腹痛、腹胀和阴道出血就诊于我们的三级医院。患者曾因异位妊娠进行过磨牙清除和左侧输卵管切除术。撤离后,患者未连续监测血清β-hCG水平。腹部超声显示子宫体积庞大,有异质、肌层浸润的肿块,怀疑子宫绒毛膜癌。鉴于发现和临床情况,我们进行了全腹子宫切除术。组织病理学检查证实浸润性痣,I期,FIGO预后评分为7分。尽管进行了咨询,但患者拒绝了辅助化疗。临床讨论:在这个罕见的病例报告中,我们讨论了异位妊娠后绝经后妇女侵袭性痣的罕见性,并强调了β-hCG监测对早期发现的重要性。结论:本病例强调了在资源有限的情况下,绝经后异位妊娠妇女侵袭性痣的诊断和治疗挑战。疏散后缺乏β-hCG监测导致识别延迟。临床医生应保持高度的怀疑指数,并强调hCG监测对GTN的早期发现和最佳管理的重要性。即使绝经后出现异常出血的妇女也应保持对GTN的高度怀疑。
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引用次数: 0
Pediatric gallbladder dyskinesia managed with laparoscopic cholecystectomy: A case report and literature review 腹腔镜胆囊切除术治疗小儿胆囊运动障碍:1例报告及文献复习
IF 0.7 Q4 SURGERY Pub Date : 2025-11-01 DOI: 10.1016/j.ijscr.2025.112131
Wail Alqatta

Introduction and importance

Gallbladder dyskinesia, also known as functional gallbladder disorder, is an uncommon cause of abdominal pain in the pediatric population, particularly in children under five years of age. It is characterized by impaired gallbladder motility in the absence of gallstones. Due to its nonspecific symptoms, diagnosis is often delayed, which may prolong morbidity.

Case presentation

This report presents a 4-year-old boy from a rural area who was referred to our surgical clinic by his pediatrician after failed conservative management of persistent abdominal pain. He had a six-month history of worsening right hypochondrial pain, intermittent fever, anorexia, nausea, and vomiting. Examination revealed right hypochondrial tenderness, a palpable mass, and guarding. Laboratory findings demonstrated leukocytosis (15.7 × 109/L), mild anemia (Hb 11.2 g/dL), and elevated C-reactive protein (68 mg/L). In this limited-resource setting, cholescintigraphy was not available. Instead, serial abdominal ultrasound scans performed after fatty meals showed persistent gallbladder hydrops with failed contraction, correlating with right hypochondrial pain, and no evidence of gallstones and a normal biliary tract. CT scan further confirmed gallbladder distension and excluded other causes of abdominal pain. Based on these findings and persistent symptoms, biliary dyskinesia was highly suspected. The patient subsequently underwent laparoscopic cholecystectomy. The postoperative recovery was uneventful, and the patient achieved complete resolution of symptoms.

Clinical discussion

Gallbladder dyskinesia in children presents diagnostic challenges because of its overlap with more common gastrointestinal conditions. Imaging is essential for detecting gallbladder pathology and ruling out alternative causes. Although conservative management is usually attempted initially, persistent symptomatic cases benefit from surgical intervention. Laparoscopic cholecystectomy offers a minimally invasive, safe, and effective option with rapid recovery and durable symptom relief, even in very young children.

Conclusion

Gallbladder dyskinesia, while rare in children, should be considered in cases of persistent biliary-type symptoms unresponsive to conservative therapy. Laparoscopic cholecystectomy provides definitive treatment and significantly improves quality of life.
胆囊运动障碍,也被称为功能性胆囊疾病,是儿科人群中罕见的腹痛原因,特别是在5岁以下儿童中。它的特点是在没有胆结石的情况下胆囊运动受损。由于其非特异性症状,诊断往往延迟,这可能延长发病率。病例介绍:本报告报告了一名来自农村地区的4岁男孩,他的儿科医生在对持续性腹痛进行保守治疗失败后转介到我们的外科诊所。他有6个月的右肋痛加重史,间歇性发热,厌食,恶心和呕吐。检查显示右侧疑软骨压痛,可触及肿块,并有守卫。实验室结果显示白细胞增多(15.7 × 109/L),轻度贫血(Hb 11.2 g/dL), c反应蛋白升高(68 mg/L)。在这种资源有限的情况下,无法进行胆管造影。相反,在高脂肪餐后进行的连续腹部超声扫描显示,持续的胆囊积液伴有收缩失败,与右侧疑软骨疼痛相关,没有胆结石和胆道正常的证据。CT扫描进一步证实胆囊膨胀,排除其他原因引起的腹痛。基于这些发现和持续的症状,胆道运动障碍被高度怀疑。患者随后接受了腹腔镜胆囊切除术。术后恢复顺利,患者症状完全缓解。儿童全膀胱运动障碍的诊断具有挑战性,因为它与更常见的胃肠道疾病重叠。成像是必要的检测胆囊病理和排除其他原因。虽然最初通常采取保守治疗,但持续症状的病例可通过手术治疗。腹腔镜胆囊切除术提供了一种微创、安全、有效的选择,恢复迅速,症状持久缓解,即使在非常年幼的儿童中也是如此。结论全膀胱运动障碍虽然在儿童中很少见,但在持续胆道型症状对保守治疗无反应的病例中应考虑。腹腔镜胆囊切除术提供了明确的治疗,并显著提高了生活质量。
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International Journal of Surgery Case Reports
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