首页 > 最新文献

International Journal of Surgery Case Reports最新文献

英文 中文
Ankylosing spondylitis with thoracic OPLL and OYL requiring multiple surgeries: A case report 强直性脊柱炎伴胸椎上斜韧带和上斜韧带需要多次手术:1例报告
IF 0.7 Q4 SURGERY Pub Date : 2025-10-27 DOI: 10.1016/j.ijscr.2025.112127
Akinori Tani, Kazumasa Nakamura, Katsunori Fukutake, Hiroshi Takahashi, Akihito Wada

Introduction

We encountered a rare and complex case of severe kyphosis resulting from ankylosing spondylitis (AS) in conjunction with ossification of the posterior longitudinal ligament (OPLL) and the yellow ligament (OYL), which necessitated multiple surgical interventions.

Presentation of case

The patient was a 45-year-old male with a high body mass index and severe thoracolumbar rigid kyphosis caused by AS. Given the significant degree of the pelvic incidence minus lumbar lordosis (PI-LL) mismatch, a two-stage L2 and L4 pedicle subtraction osteotomy (PSO) was planned, extending from T8 to the pelvis. At that juncture, although concomitant OPLL and OYL at the thoracic spine were observed, these were excluded from the surgical plan, as there were no neurological symptoms before surgery. On the fifth postoperative day following a two-stage surgery, motor weakness and paresthesia in the lower extremities manifested. Based on the neurological findings, a diagnosis of compressive thoracic myelopathy caused by OPLL/OYL at T4–8 level was made, and extensive laminectomy with extended thoracic fusion up to T3 was successfully performed.

Discussion

In retrospect, considering the risks associated with frequent surgery, a single-stage double-level PSO might have been preferable alternative. Furthermore, preparations could have been made for additional thoracic decompression and fusion on a standby basis in case thoracic myelopathy developed due to OPLL/OYL.

Conclusion

The rapid development of thoracic myelopathy following a double-level PSO at the lumbar spine, in the presence of AS and concomitant thoracic OPLL/OYL, despite the presence of ankylosing spine and apparent loss of mobility, was not predicted.
我们遇到了一个罕见而复杂的病例,由强直性脊柱炎(AS)引起的严重后凸并后纵韧带(OPLL)和黄韧带(OYL)骨化,需要多次手术干预。患者为45岁男性,高体重指数,由AS引起的严重胸腰椎僵硬性后凸。鉴于骨盆发生率减腰椎前凸(PI-LL)不匹配的显著程度,计划进行L2和L4椎弓根减截骨术(PSO),从T8延伸到骨盆。在这一节骨眼,虽然观察到胸椎并发的OPLL和OYL,但由于术前没有神经系统症状,这些都被排除在手术计划之外。两期手术后第五天,下肢出现运动无力和感觉异常。根据神经学检查结果,诊断为T4-8节段OPLL/OYL引起的压缩性胸椎脊髓病,并成功行广泛椎板切除术并将胸椎融合至T3。回顾过去,考虑到与频繁手术相关的风险,单期双节段PSO可能是更好的选择。此外,在OPLL/OYL引起胸椎脊髓病的情况下,可以准备额外的胸椎减压和融合术作为备用。结论:尽管存在强直性脊柱和明显的活动能力丧失,但在腰椎双水平PSO后,存在AS和伴随的胸椎OPLL/OYL的情况下,胸椎脊髓病的快速发展并未得到预测。
{"title":"Ankylosing spondylitis with thoracic OPLL and OYL requiring multiple surgeries: A case report","authors":"Akinori Tani,&nbsp;Kazumasa Nakamura,&nbsp;Katsunori Fukutake,&nbsp;Hiroshi Takahashi,&nbsp;Akihito Wada","doi":"10.1016/j.ijscr.2025.112127","DOIUrl":"10.1016/j.ijscr.2025.112127","url":null,"abstract":"<div><h3>Introduction</h3><div>We encountered a rare and complex case of severe kyphosis resulting from ankylosing spondylitis (AS) in conjunction with ossification of the posterior longitudinal ligament (OPLL) and the yellow ligament (OYL), which necessitated multiple surgical interventions.</div></div><div><h3>Presentation of case</h3><div>The patient was a 45-year-old male with a high body mass index and severe thoracolumbar rigid kyphosis caused by AS. Given the significant degree of the pelvic incidence minus lumbar lordosis (PI-LL) mismatch, a two-stage L2 and L4 pedicle subtraction osteotomy (PSO) was planned, extending from T8 to the pelvis. At that juncture, although concomitant OPLL and OYL at the thoracic spine were observed, these were excluded from the surgical plan, as there were no neurological symptoms before surgery. On the fifth postoperative day following a two-stage surgery, motor weakness and paresthesia in the lower extremities manifested. Based on the neurological findings, a diagnosis of compressive thoracic myelopathy caused by OPLL/OYL at T4–8 level was made, and extensive laminectomy with extended thoracic fusion up to T3 was successfully performed.</div></div><div><h3>Discussion</h3><div>In retrospect, considering the risks associated with frequent surgery, a single-stage double-level PSO might have been preferable alternative. Furthermore, preparations could have been made for additional thoracic decompression and fusion on a standby basis in case thoracic myelopathy developed due to OPLL/OYL.</div></div><div><h3>Conclusion</h3><div>The rapid development of thoracic myelopathy following a double-level PSO at the lumbar spine, in the presence of AS and concomitant thoracic OPLL/OYL, despite the presence of ankylosing spine and apparent loss of mobility, was not predicted.</div></div>","PeriodicalId":48113,"journal":{"name":"International Journal of Surgery Case Reports","volume":"137 ","pages":"Article 112127"},"PeriodicalIF":0.7,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145419938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Survival against anatomical odds: Management of a 143-cm transdiaphragmatic, transspinal rod impalement-A case report 解剖上的生存困难:143厘米经膈、经脊柱棒穿刺的处理- 1例报告
IF 0.7 Q4 SURGERY Pub Date : 2025-10-26 DOI: 10.1016/j.ijscr.2025.112104
Suman Adhikari , Aashutosh Jha , Binod Bade Shrestha , Sushil Mishra , Mrigendra Raj Pandey , Pradeep Ghimire

Introduction

Impalement injuries are rare but often fatal injuries due to their complex nature involving multiple organ systems and the risk of massive hemorrhage. Patient outcome depends upon early resuscitation, the location, extent of organ involvement and post-operative care.

Presentation of the case

We report a case of a 55-year-old man who fell onto an exposed rod from approximately 10 ft in height. On presentation to the Emergency Department in an ambulance, he was hemodynamically stable. He had absent sensory and motor functions below the T7-T8 levels of the trunk. Multiplanar CT showed rod impalement traversing the abdomen, thorax, and vertebral canal causing spinal cord transection, but without visceral/vascular injuries. He was taken to the operating theater, and laparotomy was performed, and the rod was extracted under direct vision. Post-operatively, he was managed with broad-spectrum antibiotics and supportive measures. He was discharged on the 8th post-operative day in stable condition.

Discussion

Patients with thoracoabdominal impalement should be managed in accordance with Advanced Trauma Life Support (ATLS) principles. Computed Tomography (CT) scan is the diagnostic modality of choice. Early hemodynamic stabilization followed by definitive removal in the operating room under direct vision is recommended. Meticulous postoperative care is crucial for optimal recovery.

Conclusion

This report aims to emphasize that not all extensive impalement injuries lead to fatal outcomes. Prognosis depends on the mechanism of injury, resuscitation, management approach, and post-operative care.
刺穿伤是罕见的,但往往是致命的伤害,由于其复杂的性质涉及多器官系统和大出血的风险。患者的预后取决于早期复苏、部位、器官受累程度和术后护理。我们报告一例55岁男子从大约10英尺高跌落到一根暴露的杆上。在救护车上被送到急诊室时,他的血流动力学稳定。他没有躯干T7-T8以下的感觉和运动功能。多平面CT显示杆状穿刺穿过腹部、胸部和椎管,导致脊髓横断,但未见内脏/血管损伤。他被带到手术室,进行剖腹手术,在直视下取出棒。术后给予广谱抗生素及支持措施。术后第8天出院,病情稳定。胸腹穿刺患者应按照高级创伤生命支持(ATLS)原则进行治疗。计算机断层扫描(CT)是首选的诊断方式。建议早期血流动力学稳定,然后在直视下在手术室彻底取出。细致的术后护理是最佳康复的关键。结论本报告旨在强调并不是所有的广泛穿刺损伤都会导致致命的结果。预后取决于损伤机制、复苏、处理方法和术后护理。
{"title":"Survival against anatomical odds: Management of a 143-cm transdiaphragmatic, transspinal rod impalement-A case report","authors":"Suman Adhikari ,&nbsp;Aashutosh Jha ,&nbsp;Binod Bade Shrestha ,&nbsp;Sushil Mishra ,&nbsp;Mrigendra Raj Pandey ,&nbsp;Pradeep Ghimire","doi":"10.1016/j.ijscr.2025.112104","DOIUrl":"10.1016/j.ijscr.2025.112104","url":null,"abstract":"<div><h3>Introduction</h3><div>Impalement injuries are rare but often fatal injuries due to their complex nature involving multiple organ systems and the risk of massive hemorrhage. Patient outcome depends upon early resuscitation, the location, extent of organ involvement and post-operative care.</div></div><div><h3>Presentation of the case</h3><div>We report a case of a 55-year-old man who fell onto an exposed rod from approximately 10 ft in height. On presentation to the Emergency Department in an ambulance, he was hemodynamically stable. He had absent sensory and motor functions below the T7-T8 levels of the trunk. Multiplanar CT showed rod impalement traversing the abdomen, thorax, and vertebral canal causing spinal cord transection, but without visceral/vascular injuries. He was taken to the operating theater, and laparotomy was performed, and the rod was extracted under direct vision. Post-operatively, he was managed with broad-spectrum antibiotics and supportive measures. He was discharged on the 8th post-operative day in stable condition.</div></div><div><h3>Discussion</h3><div>Patients with thoracoabdominal impalement should be managed in accordance with Advanced Trauma Life Support (ATLS) principles. Computed Tomography (CT) scan is the diagnostic modality of choice. Early hemodynamic stabilization followed by definitive removal in the operating room under direct vision is recommended. Meticulous postoperative care is crucial for optimal recovery.</div></div><div><h3>Conclusion</h3><div>This report aims to emphasize that not all extensive impalement injuries lead to fatal outcomes. Prognosis depends on the mechanism of injury, resuscitation, management approach, and post-operative care.</div></div>","PeriodicalId":48113,"journal":{"name":"International Journal of Surgery Case Reports","volume":"137 ","pages":"Article 112104"},"PeriodicalIF":0.7,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145467729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laparoscopic median arcuate ligament release: Successful management of Dunbar syndrome in a young male 腹腔镜正中弓状韧带松解术:成功治疗年轻男性邓巴综合征
IF 0.7 Q4 SURGERY Pub Date : 2025-10-26 DOI: 10.1016/j.ijscr.2025.112109
Sujan Paudel , Prajjwol Luitel , Abhishek Kumar Shah , Bikal Ghimire

Introduction and importance

Median arcuate ligament syndrome (MALS), also known as Dunbar syndrome, is a rare condition caused by compression of the celiac artery and/or ganglion by the median arcuate ligament. Its incidence is poorly defined, but it typically affects lean, middle-aged women. Due to its non-specific symptoms, MALS is often underdiagnosed. Although open surgery is conventional in resource-limited settings, laparoscopic approaches offer favorable outcomes.

Presentation of case

We report a case of a 24-year-old male with chronic postprandial upper abdominal pain and significant weight loss. Imaging via contrast-enhanced CT confirmed celiac artery compression consistent with MALS. He underwent successful laparoscopic median arcuate ligament release with celiac neurolysis.

Discussion

MALS presents diagnostic challenges due to its overlapping symptoms with other gastrointestinal disorders. Imaging and clinical correlation are crucial for diagnosis. While open surgery remains common in low-resource settings, laparoscopy provides reduced morbidity and quicker recovery.

Conclusion

This case highlights the importance of considering MALS in chronic postprandial pain and supports the feasibility of laparoscopic decompression as an effective treatment, even in resource-constrained environments.
中弓韧带综合征(MALS)又称邓巴综合征,是一种罕见的由中弓韧带压迫腹腔动脉和/或神经节引起的疾病。它的发病率尚不明确,但通常发生在瘦削的中年妇女身上。由于其非特异性症状,肌萎缩侧索硬化症经常被误诊。虽然开放手术在资源有限的情况下是传统的,但腹腔镜方法提供了良好的结果。我们报告一个24岁的男性慢性餐后上腹痛和体重明显下降的病例。增强CT证实腹腔动脉受压符合肌萎缩侧索硬化症。他接受了成功的腹腔镜正中弓韧带松解术和腹腔神经松解术。肌萎缩侧索硬化症由于其症状与其他胃肠道疾病重叠而提出诊断挑战。影像学和临床相关性对诊断至关重要。虽然开放手术在低资源环境中仍然很常见,但腹腔镜手术可以降低发病率并加快恢复速度。结论本病例强调了在慢性餐后疼痛中考虑MALS的重要性,并支持了腹腔镜减压作为一种有效治疗的可行性,即使在资源有限的环境下。
{"title":"Laparoscopic median arcuate ligament release: Successful management of Dunbar syndrome in a young male","authors":"Sujan Paudel ,&nbsp;Prajjwol Luitel ,&nbsp;Abhishek Kumar Shah ,&nbsp;Bikal Ghimire","doi":"10.1016/j.ijscr.2025.112109","DOIUrl":"10.1016/j.ijscr.2025.112109","url":null,"abstract":"<div><h3>Introduction and importance</h3><div>Median arcuate ligament syndrome (MALS), also known as Dunbar syndrome, is a rare condition caused by compression of the celiac artery and/or ganglion by the median arcuate ligament. Its incidence is poorly defined, but it typically affects lean, middle-aged women. Due to its non-specific symptoms, MALS is often underdiagnosed. Although open surgery is conventional in resource-limited settings, laparoscopic approaches offer favorable outcomes.</div></div><div><h3>Presentation of case</h3><div>We report a case of a 24-year-old male with chronic postprandial upper abdominal pain and significant weight loss. Imaging via contrast-enhanced CT confirmed celiac artery compression consistent with MALS. He underwent successful laparoscopic median arcuate ligament release with celiac neurolysis.</div></div><div><h3>Discussion</h3><div>MALS presents diagnostic challenges due to its overlapping symptoms with other gastrointestinal disorders. Imaging and clinical correlation are crucial for diagnosis. While open surgery remains common in low-resource settings, laparoscopy provides reduced morbidity and quicker recovery.</div></div><div><h3>Conclusion</h3><div>This case highlights the importance of considering MALS in chronic postprandial pain and supports the feasibility of laparoscopic decompression as an effective treatment, even in resource-constrained environments.</div></div>","PeriodicalId":48113,"journal":{"name":"International Journal of Surgery Case Reports","volume":"137 ","pages":"Article 112109"},"PeriodicalIF":0.7,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145419806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Congenital broncho-esophageal fistula; presenting as recurrent pneumonia in a 10-years-old child: A case report 先天性支气管-食管瘘;表现为复发性肺炎的10岁儿童:1例报告
IF 0.7 Q4 SURGERY Pub Date : 2025-10-26 DOI: 10.1016/j.ijscr.2025.112116
Seifu Alemu , Gersam Abera , Ashenafi Kasaye , Hasen Muhammed , Wondu Reta Demissie

Background and importance

Congenital broncho-esophageal fistula (BEF) is a rare developmental anomaly where there is an abnormal communication between the esophagus and the bronchial tree. Unlike tracheoesophageal fistulas (TEF) which is often diagnosed in neonates, isolated BEF may go undiagnosed until later age and present as recurrent respiratory infections or chronic cough triggered by feeding. The problem may go undiagnosed as it is often mistaken for other common causes of cough in children like pneumonia and bronchial asthma or other hyperactive airway diseases.

Case presentation

This is a case of a 10 years old female who presented with recurrent pneumonia and chronic cough exacerbated by feeding and episodes of choking. She had multiple admissions since early ages and was treated with antibiotics. No remarkable physical finding on the systemic examination except for crepitations on the right lower lung fields. Routine laboratory tests were performed and diagnosis confirmed by imaging which showed a broncho-esophageal fistula connecting the esophagus to the right main bronchus. After a course of parenteral antibiotics, a right postero-lateral thoracotomy with surgical division and closure of the fistula was performed, and finally she he was discharged in good condition on the 8th postoperative day.

Clinical discussion

Congenital BEF is a rare anomaly caused by incomplete separation of the foregut during embryogenesis resulting in a communication between the esophagus and the bronchial tree, and it is estimated to be less than 0.1 % of all congenital anomalies. This communication allows ingested material such as food, saliva and gastric contents to enter the airway and patients are prone to chronic pulmonary inflammation, recurrent respiratory infections and eventually bronchiectasis. Patients with BEF often present with recurrent pneumonia to the same pulmonary segment, chronic cough worsened by swallowing, choking episodes and occasionally hemoptysis. In this case the patient's recurrent pneumonia, chronic cough on feeding and choking on liquids were the hallmarks of esophago-respiratory communication.

Conclusion

This case highlights the importance of considering congenital broncho-esophageal fistula in children with recurrent respiratory infections and feeding related cough. The key to a prompt diagnosis and timely treatment remains high index of suspicion and considering a diagnostic imaging (barium esophagogram) in such patients.
背景及重要性生殖支气管-食管瘘(BEF)是一种罕见的发育异常,存在于食管和支气管树之间的异常通信。与通常在新生儿中诊断的气管食管瘘(TEF)不同,孤立的BEF可能直到晚年才被诊断出来,并表现为反复呼吸道感染或喂养引发的慢性咳嗽。这个问题可能无法诊断,因为它经常被误认为是儿童咳嗽的其他常见原因,如肺炎、支气管哮喘或其他过度活跃的气道疾病。这是一个10岁女性的病例,她表现为复发性肺炎和慢性咳嗽,因进食和发作性窒息而加重。她从小就多次入院,并接受了抗生素治疗。全身检查未见明显体征,右下肺野有搏动。常规实验室检查和影像学证实诊断显示支气管食管瘘连接食管和右主支气管。经1个疗程的肠外抗生素治疗后,行右后外侧开胸术,手术切开并关闭瘘管,最终于术后第8天顺利出院。临床讨论先天性BEF是一种罕见的异常,由于胚胎发生时前肠不完全分离,导致食管和支气管树之间的通信,估计在所有先天性异常中不到0.1%。这种交流使食物、唾液和胃内容物等摄入的物质进入气道,患者容易发生慢性肺部炎症、反复呼吸道感染,最终导致支气管扩张。BEF患者通常表现为同一肺段复发性肺炎,慢性咳嗽加重,吞咽,窒息发作,偶尔咯血。本例患者复发性肺炎,进食时慢性咳嗽和液体窒息是食道-呼吸沟通的标志。结论本病例强调了在反复呼吸道感染和喂养相关性咳嗽患儿中考虑先天性支气管食管瘘的重要性。对于此类患者,及时诊断和及时治疗的关键仍然是高度怀疑和考虑诊断性影像学(钡餐食管造影)。
{"title":"Congenital broncho-esophageal fistula; presenting as recurrent pneumonia in a 10-years-old child: A case report","authors":"Seifu Alemu ,&nbsp;Gersam Abera ,&nbsp;Ashenafi Kasaye ,&nbsp;Hasen Muhammed ,&nbsp;Wondu Reta Demissie","doi":"10.1016/j.ijscr.2025.112116","DOIUrl":"10.1016/j.ijscr.2025.112116","url":null,"abstract":"<div><h3>Background and importance</h3><div>Congenital broncho-esophageal fistula (BEF) is a rare developmental anomaly where there is an abnormal communication between the esophagus and the bronchial tree. Unlike tracheoesophageal fistulas (TEF) which is often diagnosed in neonates, isolated BEF may go undiagnosed until later age and present as recurrent respiratory infections or chronic cough triggered by feeding. The problem may go undiagnosed as it is often mistaken for other common causes of cough in children like pneumonia and bronchial asthma or other hyperactive airway diseases.</div></div><div><h3>Case presentation</h3><div>This is a case of a 10 years old female who presented with recurrent pneumonia and chronic cough exacerbated by feeding and episodes of choking. She had multiple admissions since early ages and was treated with antibiotics. No remarkable physical finding on the systemic examination except for crepitations on the right lower lung fields. Routine laboratory tests were performed and diagnosis confirmed by imaging which showed a broncho-esophageal fistula connecting the esophagus to the right main bronchus. After a course of parenteral antibiotics, a right postero-lateral thoracotomy with surgical division and closure of the fistula was performed, and finally she he was discharged in good condition on the 8th postoperative day.</div></div><div><h3>Clinical discussion</h3><div>Congenital BEF is a rare anomaly caused by incomplete separation of the foregut during embryogenesis resulting in a communication between the esophagus and the bronchial tree, and it is estimated to be less than 0.1 % of all congenital anomalies. This communication allows ingested material such as food, saliva and gastric contents to enter the airway and patients are prone to chronic pulmonary inflammation, recurrent respiratory infections and eventually bronchiectasis. Patients with BEF often present with recurrent pneumonia to the same pulmonary segment, chronic cough worsened by swallowing, choking episodes and occasionally hemoptysis. In this case the patient's recurrent pneumonia, chronic cough on feeding and choking on liquids were the hallmarks of esophago-respiratory communication.</div></div><div><h3>Conclusion</h3><div>This case highlights the importance of considering congenital broncho-esophageal fistula in children with recurrent respiratory infections and feeding related cough. The key to a prompt diagnosis and timely treatment remains high index of suspicion and considering a diagnostic imaging (barium esophagogram) in such patients.</div></div>","PeriodicalId":48113,"journal":{"name":"International Journal of Surgery Case Reports","volume":"137 ","pages":"Article 112116"},"PeriodicalIF":0.7,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145419812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical management of renal cell carcinoma with extension into the inferior vena cava and right atrium: A case report 肾细胞癌扩散至下腔静脉及右心房的手术治疗1例
IF 0.7 Q4 SURGERY Pub Date : 2025-10-26 DOI: 10.1016/j.ijscr.2025.112117
Muhammad Arza Putra , Agus Rizal Ardy Hariandy Hamid , Fakhri Ramhan , David Hutagaol , Konda Kinanti Muroso , Renaldi Prasetio

Introduction

Metastatic heart tumors are more prevalent than primary cardiac tumors. Renal cell carcinoma (RCC) is one of the tumor that can spread to the Inferior Vena Cava (IVC) to the right heart chamber. We present the Case of RCC with extension into the IVC and Right Atrium with surgical treatment and approach.

Case description

40-years old male experienced shortness of breath 3 months prior. PET CT-scan showed Lobulated hypermetabolic mass with malignant aspect measuring ±68.6 × 64.9 mm with necrotic area in the right renal lower pole corresponds to RCC. Tumor thrombus (TT) of the inferior vena cava reaches the right atrium. Transthoracic echocardiography showed multiple lobe thrombus from the IVC entering the RA. Surgical therapy with excision of right kidney tumor and TT into the IVC and RA with cardiopulmonary bypass (CPB).

Clinical decision

The thrombus was Mayo grade 4, preoperative imaging and intraoperative findings confirmed a short, mobile, non-adherent thrombus without caval wall invasion. Complete removal was achieved with CPB alone, omitting DHCA. Intraoperative transoesophageal echocardiography guided safe extraction, reducing procedural complexity and avoiding DHCA-related risks.

Conclusion

Management of RCC with RA extension requires precise assessment of thrombus level, morphology, and metastatic status. In selected Mayo grade 4 cases without wall adhesion, friable thrombus, or valve involvement, CPB without DHCA is a safe alternative, minimizing perioperative morbidity. DHCA should be prioritized when adhesion, friability, or valve extension is present.
转移性心脏肿瘤比原发性心脏肿瘤更为普遍。肾细胞癌(RCC)是一种可以扩散到下腔静脉(IVC)到右心腔的肿瘤。我们在此报告一例肾细胞癌延伸至下腔静脉和右心房的手术治疗和入路。病例描述:40岁男性,3个月前出现呼吸急促。PET扫描示分叶状高代谢肿块,恶性面为±68.6 × 64.9 mm,右肾下极坏死区为肾细胞癌。下腔静脉肿瘤血栓(TT)到达右心房。经胸超声心动图显示下腔静脉多叶血栓进入RA。手术治疗包括右肾肿瘤切除及TT入腔及体外循环(CPB)。该血栓为Mayo 4级,术前和术中影像学检查证实为短时间、可移动、非粘连血栓,未侵犯腔壁。仅CPB即可完全去除,不需要DHCA。术中经食管超声心动图引导安全拔出,降低操作复杂性,避免dhca相关风险。结论对伴有RA扩展的RCC的治疗需要精确评估血栓水平、形态和转移状态。在没有壁粘连、易碎血栓或瓣膜受累的Mayo 4级病例中,不带DHCA的CPB是一种安全的选择,可以最大限度地减少围手术期的发病率。当存在粘连、易碎性或阀门延长时,应优先使用DHCA。
{"title":"Surgical management of renal cell carcinoma with extension into the inferior vena cava and right atrium: A case report","authors":"Muhammad Arza Putra ,&nbsp;Agus Rizal Ardy Hariandy Hamid ,&nbsp;Fakhri Ramhan ,&nbsp;David Hutagaol ,&nbsp;Konda Kinanti Muroso ,&nbsp;Renaldi Prasetio","doi":"10.1016/j.ijscr.2025.112117","DOIUrl":"10.1016/j.ijscr.2025.112117","url":null,"abstract":"<div><h3>Introduction</h3><div>Metastatic heart tumors are more prevalent than primary cardiac tumors. Renal cell carcinoma (RCC) is one of the tumor that can spread to the Inferior Vena Cava (IVC) to the right heart chamber. We present the Case of RCC with extension into the IVC and Right Atrium with surgical treatment and approach.</div></div><div><h3>Case description</h3><div>40-years old male experienced shortness of breath 3 months prior. PET CT-scan showed Lobulated hypermetabolic mass with malignant aspect measuring ±68.6 × 64.9 mm with necrotic area in the right renal lower pole corresponds to RCC. Tumor thrombus (TT) of the inferior vena cava reaches the right atrium. Transthoracic echocardiography showed multiple lobe thrombus from the IVC entering the RA. Surgical therapy with excision of right kidney tumor and TT into the IVC and RA with cardiopulmonary bypass (CPB).</div></div><div><h3>Clinical decision</h3><div>The thrombus was Mayo grade 4, preoperative imaging and intraoperative findings confirmed a short, mobile, non-adherent thrombus without caval wall invasion. Complete removal was achieved with CPB alone, omitting DHCA. Intraoperative transoesophageal echocardiography guided safe extraction, reducing procedural complexity and avoiding DHCA-related risks.</div></div><div><h3>Conclusion</h3><div>Management of RCC with RA extension requires precise assessment of thrombus level, morphology, and metastatic status. In selected Mayo grade 4 cases without wall adhesion, friable thrombus, or valve involvement, CPB without DHCA is a safe alternative, minimizing perioperative morbidity. DHCA should be prioritized when adhesion, friability, or valve extension is present.</div></div>","PeriodicalId":48113,"journal":{"name":"International Journal of Surgery Case Reports","volume":"137 ","pages":"Article 112117"},"PeriodicalIF":0.7,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145419811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case report: Secondary peristomal cutaneous squamous cell carcinoma following multimodal treatment for rectal cancer 病例报告:直肠癌多模式治疗后继发表皮鳞状细胞癌
IF 0.7 Q4 SURGERY Pub Date : 2025-10-26 DOI: 10.1016/j.ijscr.2025.112112
Elena Knochenhauer , Andre Schreiber , Anne Glitsch , Stephan Kersting

Introduction

This case report describes the rare development of a highly differentiated, keratinising squamous cell carcinoma on the skin of the anus praeter following multimodal therapy for rectal cancer. The case was successfully managed through structured follow-up care and interdisciplinary collaboration.

Case presentation

We report on the complex case of a patient with rectal carcinoma, which was treated with neoadjuvant radiochemotherapy, followed by surgical resection and adjuvant chemotherapy. During treatment, a low anterior resection syndrome developed, resulting in the creation of an end colostomy. Verrucous skin ulcerations developed around the stoma, leading to the development of squamous cell carcinoma of the skin based on this chronic inflammation.

Discussion

Secondary malignancies are a significant late complication of radiotherapy or combined radiochemotherapy. While high doses of radiation cause cell death, malignant transformations can be promoted in the low-dose peripheral areas of the radiation fields. In the present case, however, the chronic inflammatory skin change indicates inflammation-induced carcinogenesis, which is described in the literature as a central pathogenetic mechanism.

Conclusion

This case highlights the importance of close follow-up care and a holistic approach to patient care. It also illustrates the importance of recognising and managing treatment complications. Furthermore, it raises awareness of the development of secondary malignancies and malignant transformations.
本病例报告描述了一种罕见的高度分化,角化鳞状细胞癌的发展在肛门的皮肤后,多模式治疗直肠癌。通过结构化的后续护理和跨学科合作,成功地管理了该病例。我们报告了一例复杂的直肠癌患者,接受了新辅助放化疗,手术切除和辅助化疗。在治疗过程中,低前切除术综合征的发展,导致创建一个末端结肠造口。疣状皮肤溃疡在造口周围发展,导致基于这种慢性炎症的皮肤鳞状细胞癌的发展。继发性恶性肿瘤是放疗或放化疗的重要晚期并发症。虽然高剂量的辐射导致细胞死亡,但在辐射场的低剂量外围区域可促进恶性转化。然而,在本病例中,慢性炎症性皮肤变化表明炎症诱导的癌变,这在文献中被描述为中心发病机制。结论本病例强调了密切随访护理和整体护理的重要性。它还说明了认识和管理治疗并发症的重要性。此外,它提高了对继发性恶性肿瘤和恶性转化发展的认识。
{"title":"Case report: Secondary peristomal cutaneous squamous cell carcinoma following multimodal treatment for rectal cancer","authors":"Elena Knochenhauer ,&nbsp;Andre Schreiber ,&nbsp;Anne Glitsch ,&nbsp;Stephan Kersting","doi":"10.1016/j.ijscr.2025.112112","DOIUrl":"10.1016/j.ijscr.2025.112112","url":null,"abstract":"<div><h3>Introduction</h3><div>This case report describes the rare development of a highly differentiated, keratinising squamous cell carcinoma on the skin of the anus praeter following multimodal therapy for rectal cancer. The case was successfully managed through structured follow-up care and interdisciplinary collaboration.</div></div><div><h3>Case presentation</h3><div>We report on the complex case of a patient with rectal carcinoma, which was treated with neoadjuvant radiochemotherapy, followed by surgical resection and adjuvant chemotherapy. During treatment, a low anterior resection syndrome developed, resulting in the creation of an end colostomy. Verrucous skin ulcerations developed around the stoma, leading to the development of squamous cell carcinoma of the skin based on this chronic inflammation.</div></div><div><h3>Discussion</h3><div>Secondary malignancies are a significant late complication of radiotherapy or combined radiochemotherapy. While high doses of radiation cause cell death, malignant transformations can be promoted in the low-dose peripheral areas of the radiation fields. In the present case, however, the chronic inflammatory skin change indicates inflammation-induced carcinogenesis, which is described in the literature as a central pathogenetic mechanism.</div></div><div><h3>Conclusion</h3><div>This case highlights the importance of close follow-up care and a holistic approach to patient care. It also illustrates the importance of recognising and managing treatment complications. Furthermore, it raises awareness of the development of secondary malignancies and malignant transformations.</div></div>","PeriodicalId":48113,"journal":{"name":"International Journal of Surgery Case Reports","volume":"137 ","pages":"Article 112112"},"PeriodicalIF":0.7,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145419727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical diagnosis and challenges in management of Osteogenesis Imperfecta in a resource-limited setting — A case report and review of literature 在资源有限的情况下,成骨不全症的临床诊断和治疗挑战-一个病例报告和文献回顾
IF 0.7 Q4 SURGERY Pub Date : 2025-10-25 DOI: 10.1016/j.ijscr.2025.112077
Dinesh Kumar Pandit , Samagya Paudel , Hem Shankar Yadav, Kshitiz Shrestha, Roshika Ghatani, Pia Rai

Introduction

Pediatric bone fragility presents a significant diagnostic challenge, often leading to misdiagnosis between conditions like rickets and Osteogenesis Imperfecta (OI). Accurate differentiation is crucial for effective management due to the varying underlying pathophysiologies.

Case presentation

This report details the diagnostic journey of a 10-year-old male who initially presented with recurrent femoral shaft fractures and was misdiagnosed with rickets. Despite conventional treatment, persistent symptoms and the emergence of classic OI features, such as grey sclera and dentinogenesis imperfecta, prompted re-evaluation and ultimately led to a diagnosis of Osteogenesis Imperfecta Type I.

Discussion

This case highlights the complexities of diagnosing rare genetic bone disorders that mimic more common conditions. Challenges include limited access to advanced diagnostics like genetic testing and the need for a high index of suspicion in atypical presentations. The importance of a multidisciplinary approach to OI management and early diagnosis for patient and family support is emphasized. The case also highlights the necessity of thoroughly investigating the underlying causes of pathological fractures.

Conclusion

This case report illustrates the diagnostic pitfalls in pediatric bone fragility and reinforces the need for comprehensive clinical assessment and appropriate investigations to avoid misdiagnosis of conditions like OI. Early and accurate diagnosis is crucial for effective management and improved patient outcomes.
儿童骨脆性是一个重大的诊断挑战,经常导致佝偻病和成骨不全症(OI)之间的误诊。由于不同的潜在病理生理特征,准确的鉴别对于有效的治疗至关重要。本报告详细介绍了一名10岁男性的诊断过程,他最初表现为复发性股骨干骨折,并被误诊为佝偻病。尽管进行了常规治疗,但持续的症状和典型成骨不全特征的出现,如灰色巩膜和牙本质发育不全,促使患者进行重新评估,并最终诊断为成骨不全i型。挑战包括获得基因检测等先进诊断的机会有限,以及需要对非典型症状进行高度怀疑。强调了多学科方法对成骨不全症管理和早期诊断以及患者和家属支持的重要性。该病例也强调了彻底调查病理性骨折的根本原因的必要性。结论本病例报告说明了儿童骨脆性的诊断缺陷,并强调了全面的临床评估和适当的调查的必要性,以避免误诊如成骨不全。早期和准确的诊断对于有效管理和改善患者预后至关重要。
{"title":"Clinical diagnosis and challenges in management of Osteogenesis Imperfecta in a resource-limited setting — A case report and review of literature","authors":"Dinesh Kumar Pandit ,&nbsp;Samagya Paudel ,&nbsp;Hem Shankar Yadav,&nbsp;Kshitiz Shrestha,&nbsp;Roshika Ghatani,&nbsp;Pia Rai","doi":"10.1016/j.ijscr.2025.112077","DOIUrl":"10.1016/j.ijscr.2025.112077","url":null,"abstract":"<div><h3>Introduction</h3><div>Pediatric bone fragility presents a significant diagnostic challenge, often leading to misdiagnosis between conditions like rickets and Osteogenesis Imperfecta (OI). Accurate differentiation is crucial for effective management due to the varying underlying pathophysiologies.</div></div><div><h3>Case presentation</h3><div>This report details the diagnostic journey of a 10-year-old male who initially presented with recurrent femoral shaft fractures and was misdiagnosed with rickets. Despite conventional treatment, persistent symptoms and the emergence of classic OI features, such as grey sclera and dentinogenesis imperfecta, prompted re-evaluation and ultimately led to a diagnosis of Osteogenesis Imperfecta Type I.</div></div><div><h3>Discussion</h3><div>This case highlights the complexities of diagnosing rare genetic bone disorders that mimic more common conditions. Challenges include limited access to advanced diagnostics like genetic testing and the need for a high index of suspicion in atypical presentations. The importance of a multidisciplinary approach to OI management and early diagnosis for patient and family support is emphasized. The case also highlights the necessity of thoroughly investigating the underlying causes of pathological fractures.</div></div><div><h3>Conclusion</h3><div>This case report illustrates the diagnostic pitfalls in pediatric bone fragility and reinforces the need for comprehensive clinical assessment and appropriate investigations to avoid misdiagnosis of conditions like OI. Early and accurate diagnosis is crucial for effective management and improved patient outcomes.</div></div>","PeriodicalId":48113,"journal":{"name":"International Journal of Surgery Case Reports","volume":"137 ","pages":"Article 112077"},"PeriodicalIF":0.7,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145419892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gallbladder ascariasis complicated by chronic eosinophilic cholecystitis in a one-year-old infant: A case report 一岁婴儿胆囊蛔虫病合并慢性嗜酸性胆囊炎1例报告
IF 0.7 Q4 SURGERY Pub Date : 2025-10-25 DOI: 10.1016/j.ijscr.2025.112105
Israa Saad , Ahmed Ayoub , Mohamed Abouheba , Saber Waheeb , Nada Yakout , Mostafa Zain

Introduction & importance

Ascaris lumbricoides is one of the most prevalent soil-transmitted helminths, affecting up to 1.2 billion people worldwide. Although it mainly inhabits the intestine, migration to the biliary system can occur. Gallbladder involvement is exceptionally rare, particularly in children.

Case presentation

We report a one-year-old male with recurrent fever, anorexia, vomiting, and weight loss for three months. Past history included neonatal intensive care for hypoplastic lungs, anemia, and sepsis. Examination revealed mild epigastric and right hypochondrial tenderness. Laboratory results showed eosinophilia, and stool analysis confirmed Ascaris ova. Abdominal ultrasound demonstrated hepatomegaly, gallbladder wall thickening, and a hyperechoic mobile lesion suggestive of Ascaris.

Clinical discussion

Gallbladder ascariasis is extremely uncommon in infants, with only two previously reported cases under one year of age, which were managed conservatively. Clinical features are nonspecific, overlapping with other gastrointestinal disorders. Ultrasound is the diagnostic tool of choice, revealing typical hyperechoic intraluminal structures. In this case, laparoscopic cholecystectomy confirmed a degenerated worm with chronic eosinophilic cholecystitis. While conservative management with anthelmintics is standard, surgery is indicated for complications such as cholecystitis or worm impaction.

Conclusion

Although uncommon, Ascaris lumbricoides may migrate into the gallbladder, resulting in symptomatic cholecystitis. In endemic regions, gallbladder ascariasis should be considered in the differential diagnosis of patients with unexplained gastrointestinal or biliary symptoms. Early recognition through a high index of suspicion and timely ultrasonographic evaluation is essential for accurate diagnosis and optimal management. Peripheral eosinophilia, reflecting the host immune response to parasitic infestation, may provide an additional diagnostic clue.
类蚓蛔虫是最普遍的土壤传播蠕虫之一,影响全世界多达12亿人。虽然它主要居住在肠道,但也可以迁移到胆道系统。胆囊受累极为罕见,尤其是儿童。病例报告:我们报告一一岁男性复发性发热、厌食、呕吐及体重下降三个月。既往病史包括新生儿重症监护肺发育不良、贫血和败血症。检查发现轻度上腹部和右侧下丘脑压痛。实验室结果显示嗜酸性粒细胞增多,粪便分析证实蛔虫卵。腹部超声显示肝肿大,胆囊壁增厚,高回声移动病灶提示蛔虫病。临床讨论:全膀胱蛔虫病在婴儿中极为罕见,以前仅报道过两例一岁以下的病例,均采用保守治疗。临床特征无特异性,与其他胃肠道疾病重叠。超声是诊断工具的选择,显示典型的高回声腔内结构。在这个病例中,腹腔镜胆囊切除术证实了一个退化的蠕虫慢性嗜酸性胆囊炎。虽然使用驱虫药的保守治疗是标准的,但手术是指胆囊炎或蠕虫嵌塞等并发症。结论类蚓蛔虫虽不常见,但可移入胆囊,引起症状性胆囊炎。在流行地区,胆囊蛔虫病应考虑在鉴别诊断患者不明原因的胃肠道或胆道症状。通过高怀疑指数的早期识别和及时的超声检查对准确诊断和优化治疗至关重要。外周嗜酸性粒细胞增多,反映宿主对寄生虫感染的免疫反应,可能提供额外的诊断线索。
{"title":"Gallbladder ascariasis complicated by chronic eosinophilic cholecystitis in a one-year-old infant: A case report","authors":"Israa Saad ,&nbsp;Ahmed Ayoub ,&nbsp;Mohamed Abouheba ,&nbsp;Saber Waheeb ,&nbsp;Nada Yakout ,&nbsp;Mostafa Zain","doi":"10.1016/j.ijscr.2025.112105","DOIUrl":"10.1016/j.ijscr.2025.112105","url":null,"abstract":"<div><h3>Introduction &amp; importance</h3><div>Ascaris lumbricoides is one of the most prevalent soil-transmitted helminths, affecting up to 1.2 billion people worldwide. Although it mainly inhabits the intestine, migration to the biliary system can occur. Gallbladder involvement is exceptionally rare, particularly in children.</div></div><div><h3>Case presentation</h3><div>We report a one-year-old male with recurrent fever, anorexia, vomiting, and weight loss for three months. Past history included neonatal intensive care for hypoplastic lungs, anemia, and sepsis. Examination revealed mild epigastric and right hypochondrial tenderness. Laboratory results showed eosinophilia, and stool analysis confirmed Ascaris ova. Abdominal ultrasound demonstrated hepatomegaly, gallbladder wall thickening, and a hyperechoic mobile lesion suggestive of Ascaris.</div></div><div><h3>Clinical discussion</h3><div>Gallbladder ascariasis is extremely uncommon in infants, with only two previously reported cases under one year of age, which were managed conservatively. Clinical features are nonspecific, overlapping with other gastrointestinal disorders. Ultrasound is the diagnostic tool of choice, revealing typical hyperechoic intraluminal structures. In this case, laparoscopic cholecystectomy confirmed a degenerated worm with chronic eosinophilic cholecystitis. While conservative management with anthelmintics is standard, surgery is indicated for complications such as cholecystitis or worm impaction.</div></div><div><h3>Conclusion</h3><div>Although uncommon, Ascaris lumbricoides may migrate into the gallbladder, resulting in symptomatic cholecystitis. In endemic regions, gallbladder ascariasis should be considered in the differential diagnosis of patients with unexplained gastrointestinal or biliary symptoms. Early recognition through a high index of suspicion and timely ultrasonographic evaluation is essential for accurate diagnosis and optimal management. Peripheral eosinophilia, reflecting the host immune response to parasitic infestation, may provide an additional diagnostic clue.</div></div>","PeriodicalId":48113,"journal":{"name":"International Journal of Surgery Case Reports","volume":"137 ","pages":"Article 112105"},"PeriodicalIF":0.7,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ovarian mesonephric-like adenocarcinoma mimicking serous carcinoma: A case report integrating cytologic, frozen, histological, immunohistochemistry, and molecular analyses 卵巢中肾样腺癌模拟浆液性癌:结合细胞学、冷冻、组织学、免疫组织化学和分子分析的一例报告
IF 0.7 Q4 SURGERY Pub Date : 2025-10-25 DOI: 10.1016/j.ijscr.2025.112106
Wanrun Lin , Suming Huang , Xin Zhou , Lei Qin , Wenxin Zheng , Feng Zhou

Introduction

Mesonephric-like adenocarcinoma (MLA) is a recently recognized, rare subtype of endometrial carcinoma that can also arise in the ovary. Ovarian MLA is uncommon and often misdiagnosed due to its varied growth patterns and overlap with more common ovarian carcinomas.

Presentation of case

We report a case of ovarian MLA that closely mimicked serous carcinoma clinically and histologically. The patient presented with a pelvic mass. Cytological analysis of peritoneal washing fluid initially raised a strong suspicion for serous carcinoma, underscoring the potential for MLA to masquerade on cytology. Intraoperative frozen section proved especially challenging: low-grade cytology and papillary-glandular architecture led to a provisional diagnosis of low-grade serous carcinoma, delaying recognition of MLA until permanent sections and ancillary stains could be performed. Formalin-fixed, paraffin-embedded sections demonstrated complex branching papillae and retiform glandular pattern with low to moderate nuclear atypia and scattered psammoma bodies, a pattern that can mimic both low-grade and high-grade serous carcinoma. Foci of endometriosis were identified in the fallopian tube, indicating the possibility of endometriosis derivation. However, immunohistochemistry showed a mesonephric profile: the tumor was diffusely positive for PAX8, GATA3, and TTF-1, while negative for estrogen receptor (ER) and progesterone receptor (PR), with wild-type p53 expression. Next-generation sequencing revealed a KRAS p.G12V mutation, low tumor mutational burden, and microsatellite stability, confirming the diagnosis of MLA.

Discussion

This case underscores the diagnostic challenges of MLA, particularly its ability to masquerade as low-grade or high-grade serous carcinoma on morphology, including cytology, frozen, and permanent sections.

Conclusion

We compare the cytologic, histologic, immunophenotypic, and molecular features of MLA and serous carcinoma, highlighting the importance of thorough evaluation to avoid the pitfall of morphology-only diagnosis.
中肾样腺癌(MLA)是最近发现的一种罕见的子宫内膜癌亚型,也可发生在卵巢。卵巢MLA并不常见,由于其不同的生长模式和与更常见的卵巢癌重叠,经常被误诊。我们报告一例卵巢MLA在临床和组织学上与浆液性癌非常相似。病人表现为盆腔肿块。腹膜洗涤液的细胞学分析最初强烈怀疑为浆液性癌,强调MLA伪装细胞学的可能性。术中冰冻切片尤其具有挑战性:低级别细胞学和乳头腺结构导致了低级别浆液性癌的临时诊断,延迟了对MLA的识别,直到可以进行永久切片和辅助染色。福尔马林固定,石蜡包埋切片显示复杂的分支乳头状和网状腺状结构,低至中度核异型性和分散的沙粒小体,这种模式可以模拟低级别和高级别浆液性癌。输卵管内发现子宫内膜异位症病灶,提示子宫内膜异位症衍生的可能性。然而,免疫组化显示中肾型:肿瘤弥漫性PAX8、GATA3、TTF-1阳性,雌激素受体(ER)、孕激素受体(PR)阴性,p53表达野生型。新一代测序结果显示KRAS p.G12V突变,肿瘤突变负荷低,微卫星稳定性好,证实了MLA的诊断。本病例强调了MLA的诊断挑战,特别是其在形态学上伪装为低级别或高级别浆液性癌的能力,包括细胞学、冷冻切片和永久切片。结论我们比较了MLA和浆液性癌的细胞学、组织学、免疫表型和分子特征,强调了全面评估的重要性,以避免单纯的形态学诊断。
{"title":"Ovarian mesonephric-like adenocarcinoma mimicking serous carcinoma: A case report integrating cytologic, frozen, histological, immunohistochemistry, and molecular analyses","authors":"Wanrun Lin ,&nbsp;Suming Huang ,&nbsp;Xin Zhou ,&nbsp;Lei Qin ,&nbsp;Wenxin Zheng ,&nbsp;Feng Zhou","doi":"10.1016/j.ijscr.2025.112106","DOIUrl":"10.1016/j.ijscr.2025.112106","url":null,"abstract":"<div><h3>Introduction</h3><div>Mesonephric-like adenocarcinoma (MLA) is a recently recognized, rare subtype of endometrial carcinoma that can also arise in the ovary. Ovarian MLA is uncommon and often misdiagnosed due to its varied growth patterns and overlap with more common ovarian carcinomas.</div></div><div><h3>Presentation of case</h3><div>We report a case of ovarian MLA that closely mimicked serous carcinoma clinically and histologically. The patient presented with a pelvic mass. Cytological analysis of peritoneal washing fluid initially raised a strong suspicion for serous carcinoma, underscoring the potential for MLA to masquerade on cytology. Intraoperative frozen section proved especially challenging: low-grade cytology and papillary-glandular architecture led to a provisional diagnosis of low-grade serous carcinoma, delaying recognition of MLA until permanent sections and ancillary stains could be performed. Formalin-fixed, paraffin-embedded sections demonstrated complex branching papillae and retiform glandular pattern with low to moderate nuclear atypia and scattered psammoma bodies, a pattern that can mimic both low-grade and high-grade serous carcinoma. Foci of endometriosis were identified in the fallopian tube, indicating the possibility of endometriosis derivation. However, immunohistochemistry showed a mesonephric profile: the tumor was diffusely positive for PAX8, GATA3, and TTF-1, while negative for estrogen receptor (ER) and progesterone receptor (PR), with wild-type p53 expression. Next-generation sequencing revealed a KRAS p.G12V mutation, low tumor mutational burden, and microsatellite stability, confirming the diagnosis of MLA.</div></div><div><h3>Discussion</h3><div>This case underscores the diagnostic challenges of MLA, particularly its ability to masquerade as low-grade or high-grade serous carcinoma on morphology, including cytology, frozen, and permanent sections.</div></div><div><h3>Conclusion</h3><div>We compare the cytologic, histologic, immunophenotypic, and molecular features of MLA and serous carcinoma, highlighting the importance of thorough evaluation to avoid the pitfall of morphology-only diagnosis.</div></div>","PeriodicalId":48113,"journal":{"name":"International Journal of Surgery Case Reports","volume":"137 ","pages":"Article 112106"},"PeriodicalIF":0.7,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145419940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SeptAlign™ biosorbable implant for correction of mobile cartilaginous nasal septum deviation: A case report SeptAlign™生物可吸收种植体用于矫正活动性鼻中隔软骨偏曲1例
IF 0.7 Q4 SURGERY Pub Date : 2025-10-25 DOI: 10.1016/j.ijscr.2025.112111
Harry E. Zylicz , Caroline Taylor , William Robertson , Mary Ellis Beach , William Barham , Henry P. Barham

Introduction

The standard of care for symptomatic nasal septal deviation in adults, refractory to medical management, is septoplasty. SeptAlign™ is a minimally-invasive, bioabsorbable implant cleared by the United States Food and Drug Administration for mechanical correction of minor nasal septal deviation and a novel alternative to traditional septoplasty.

Presentation of case

We present a case report of a 42 year old male with a history of symptomatic nasal septal deviation and nasal airway obstruction who strongly wished to avoid open surgical correction.

Discussion

We successfully implanted the SeptAlign device to correct the cartilaginous deviation with severe anterior caudal deflection. We present pre- and post-procedure computed tomography and endoscopy imaging and patient reported outcomes to demonstrate correction of nasal airway obstruction and symptoms.

Conclusion

SeptAlign is a less invasive alternative to traditional septoplasty or septorhinoplasty in patients with cartilaginous nasal septal deviation, with the added benefits of avoiding general anesthesia and the convenience of an in-office procedure.
成人症状性鼻中隔偏曲难以治疗的标准治疗方法是鼻中隔成形术。SeptAlign™是一种微创、生物可吸收的植入物,经美国食品和药物管理局批准,用于轻微鼻中隔偏曲的机械矫正,是传统鼻中隔成形术的一种新选择。我们报告一例42岁男性,有症状性鼻中隔偏曲和鼻气道阻塞病史,强烈希望避免开放手术矫正。我们成功地植入了SeptAlign装置来矫正严重的前尾侧偏软骨。我们报告了手术前后的计算机断层扫描和内窥镜成像以及患者报告的结果,以证明鼻气道阻塞和症状的纠正。结论对于软骨性鼻中隔偏曲患者,septalign是传统鼻中隔成形术或鼻中隔成形术的一种侵入性较小的替代方法,具有避免全身麻醉和在办公室操作方便的优点。
{"title":"SeptAlign™ biosorbable implant for correction of mobile cartilaginous nasal septum deviation: A case report","authors":"Harry E. Zylicz ,&nbsp;Caroline Taylor ,&nbsp;William Robertson ,&nbsp;Mary Ellis Beach ,&nbsp;William Barham ,&nbsp;Henry P. Barham","doi":"10.1016/j.ijscr.2025.112111","DOIUrl":"10.1016/j.ijscr.2025.112111","url":null,"abstract":"<div><h3>Introduction</h3><div>The standard of care for symptomatic nasal septal deviation in adults, refractory to medical management, is septoplasty. SeptAlign™ is a minimally-invasive, bioabsorbable implant cleared by the United States Food and Drug Administration for mechanical correction of minor nasal septal deviation and a novel alternative to traditional septoplasty.</div></div><div><h3>Presentation of case</h3><div>We present a case report of a 42 year old male with a history of symptomatic nasal septal deviation and nasal airway obstruction who strongly wished to avoid open surgical correction.</div></div><div><h3>Discussion</h3><div>We successfully implanted the SeptAlign device to correct the cartilaginous deviation with severe anterior caudal deflection. We present pre- and post-procedure computed tomography and endoscopy imaging and patient reported outcomes to demonstrate correction of nasal airway obstruction and symptoms.</div></div><div><h3>Conclusion</h3><div>SeptAlign is a less invasive alternative to traditional septoplasty or septorhinoplasty in patients with cartilaginous nasal septal deviation, with the added benefits of avoiding general anesthesia and the convenience of an in-office procedure.</div></div>","PeriodicalId":48113,"journal":{"name":"International Journal of Surgery Case Reports","volume":"137 ","pages":"Article 112111"},"PeriodicalIF":0.7,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145419941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
International Journal of Surgery Case Reports
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1