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Divergent effects of entomopathogenic fungi and medicinal mushroom species on Drosophila melanogaster lifespan 昆虫病原真菌和药用蘑菇物种对黑腹果蝇寿命的不同影响
IF 1.2 4区 综合性期刊 Pub Date : 2024-05-23 DOI: 10.1080/26895293.2024.2356838
Md M. H. Nafis, Amran A. Q. A. Al-Shaarani, Mohammed H. M. Muafa, Yiwen Wang, Chunying Deng, Yusufjon Gafforov, Lorenzo Pecoraro
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引用次数: 0
Recent methods for the diagnosis and differentiation of ameloblastoma: a narrative review 诊断和鉴别釉母细胞瘤的最新方法:综述
IF 1.2 4区 综合性期刊 Pub Date : 2024-05-21 DOI: 10.1080/26895293.2024.2354675
Ke Hu, Xudong Zhang, Ruixue Chen, Xiangjun Li
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引用次数: 0
The AST/ALT (De Ritis) ratio as a significant prognostic factor in myelodysplastic syndrome 作为骨髓增生异常综合征重要预后因素的 AST/ALT(De Ritis)比值
IF 1.2 4区 综合性期刊 Pub Date : 2024-04-23 DOI: 10.1080/26895293.2024.2343710
Ying Chen, Yue Wu, Ting Chen, Duobing Zou, Cong Shi, Ningning Wu, Lixia Sheng, G. Ouyang, Qitian Mu
{"title":"The AST/ALT (De Ritis) ratio as a significant prognostic factor in myelodysplastic syndrome","authors":"Ying Chen, Yue Wu, Ting Chen, Duobing Zou, Cong Shi, Ningning Wu, Lixia Sheng, G. Ouyang, Qitian Mu","doi":"10.1080/26895293.2024.2343710","DOIUrl":"https://doi.org/10.1080/26895293.2024.2343710","url":null,"abstract":"","PeriodicalId":48478,"journal":{"name":"All Life","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140669138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Habitat preference and diversity of bryophyte in the Jiulongshan National Forest Park, Eastern China 九龙山国家森林公园苔藓植物的生境偏好与多样性
4区 综合性期刊 Pub Date : 2023-11-01 DOI: 10.1080/26895293.2023.2271177
Pengcheng Ye, Xiaohui Qian, Jianyong Wu, Xiao Zhao
In densely populated, highly urbanized regions such as Zhejiang Province (eastern China), species are under enormous environmental pressures resulting from human activities, land use changes, and habitat fragmentation, which affect species composition and species diversity. Although eastern China is one of the most concentrated distribution areas of endemic bryophytes in East Asia, these species are also faced with the threats of habitat inadequacy. In order to get more information on bryophyte habitat and diversity, we investigated species composition, habitat preference, as well as species diversity differences of bryophytes under different habitat conditions in Jiulongshan National Forest Park (JNFP). In particular, the results showed that 108 specimens of bryophyte were collected in total, including 46 species in 32 genera of 21 families. Furthermore, we had found 12 species of bryophytes that had never been recorded before in Zhejiang Province. Remarkably, 40.74% of bryophytes were found to grow on natural rocks, followed by understories and roadside habitats. In addition, the Patrick richness index (R) varied most significantly among different habitats (p < 0.001). In a conservation perspective, natural rocks, roadways and understories should be preserved to protect bryophyte diversity.
在人口密集、城市化程度高的地区(如浙江省),由于人类活动、土地利用变化和栖息地破碎化等因素,物种面临着巨大的环境压力,影响着物种组成和多样性。中国东部地区是东亚地区特有苔藓植物分布最集中的地区之一,但也面临着生境不足的威胁。为了进一步了解九龙山国家森林公园苔藓植物的生境和多样性,研究了九龙山国家森林公园不同生境条件下苔藓植物的种类组成、生境偏好以及物种多样性差异。其中,共采集苔藓植物108份,隶属于21科32属46种。此外,我们还发现了12种浙江省从未记录过的苔藓植物。值得注意的是,40.74%的苔藓植物生长在天然岩石上,其次是林下植被和路边生境。Patrick丰富度指数(R)在不同生境间差异最大(p < 0.001)。从保护的角度来看,应保留天然岩石、道路和林下植被,以保护苔藓植物的多样性。
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引用次数: 0
Evaluation of cytotoxic and genotoxic potential of avobenzone and octocrylene on human skin fibroblast cells 阿伏苯宗和奥克烯对人皮肤成纤维细胞的细胞毒性和基因毒性潜力的评价
4区 综合性期刊 Pub Date : 2023-10-30 DOI: 10.1080/26895293.2023.2270171
Özgür Vatan, Duygu Sevinç, Dilek Yılmaz Çelik, A. Carine Aurelie Allounan, Özgün Teksoy, Neylan Oral, Huzeyfe Huriyet, Tolga Çavaş, Nilüfer Çinkılıç
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引用次数: 0
Identification of potential hub genes and therapeutic drugs in ovarian cancer via bioinformatics analysis 通过生物信息学分析鉴定卵巢癌潜在中枢基因和治疗药物
4区 综合性期刊 Pub Date : 2023-10-30 DOI: 10.1080/26895293.2023.2270192
Xinyue Zhou, Zuofei Song, Jia Chen, Dongxue Wang, Jingli Sun
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引用次数: 0
Investigation of the content of anabolic steroids in food supplements used in sports practice 体育运动中膳食补充剂中合成代谢类固醇含量的调查
4区 综合性期刊 Pub Date : 2023-10-26 DOI: 10.1080/26895293.2023.2270722
Elina Petkova-Gueorguieva, Stanislav Gueorguiev, Hristina Lebanova, Anna Mihaylova, Vasil Madzharov
The goal of this study is to establish the presence or absence of anabolic androgenic steroids in food supplements implemented in sports practice, to assess the health risk from intake of food supplements with quality and content discrepancies in conflict with the recommendations. The authors analysed 23 samples of food supplements by using liquid chromatographic methods. The presence/absence of substances with steroid structure was determined by considering the resulting chromatograms and using reference substances. The analysis of the resulting data showed that 11 out of 23 samples of food supplements did not contain anabolic steroid substances, while different amounts of androgenic steroid substances were identified in the other 12 samples. The results from the analyses confirmed the hypothesis formulated by the authors for possible presence of undeclared steroid ingredients in food supplements, and enabled the following conclusion: more than half of the tested food supplements contained undeclared anabolic steroids, all banned by the World Anti-Doping Agency, and their number in one of the samples could be more than one. The authors also revealed that the information on the product label and package concealed the undeclared ingredients of the food supplement and claimed for high efficacy and safety.
本研究的目的是确定在运动中使用的食品补充剂中是否含有合成代谢雄激素类固醇,以评估摄入质量和含量与建议不符的食品补充剂对健康的风险。采用液相色谱法对23份食品添加剂样品进行了分析。通过考虑得到的色谱图和参考物质来确定类固醇结构物质的存在/不存在。对结果数据的分析显示,在23份食品补充剂样品中,有11份不含合成代谢类固醇物质,而在另外12份样品中发现了不同数量的雄激素类固醇物质。分析结果证实了作者提出的假设,即食品补充剂中可能存在未申报的类固醇成分,并得出以下结论:超过一半的测试食品补充剂含有未申报的合成代谢类固醇,这些类固醇都被世界反兴奋剂机构禁止使用,其中一个样本中的类固醇含量可能不止一种。作者还透露,产品标签和包装上的信息掩盖了未申报的食品补充剂成分,并声称其高效安全。
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引用次数: 0
Clinicopathological relevance of BRAF and SMO mutations in Chinese patients with ameloblastoma 中国成釉细胞瘤患者BRAF和SMO突变的临床病理相关性
4区 综合性期刊 Pub Date : 2023-10-24 DOI: 10.1080/26895293.2023.2270170
Chen Ruixue, Li Hexiang, Hou Yali, Li Xiangjun, Sun Xu, Wang Jie, Zhang Xudong
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引用次数: 0
Experimental validation and bioinformatics analysis of hub genes in myocardial infarction 心肌梗死中心基因的实验验证及生物信息学分析
4区 综合性期刊 Pub Date : 2023-09-26 DOI: 10.1080/26895293.2023.2255753
Li-Jun Wang, Bai-Quan Qiu, Hua-Xi Zou, Cheng-Wu Gong, Song-Qing Lai, Jian-Jun Xu, Yong-Bing Wu, Ji-Chun Liu
There is an urgent need to explore and validate novel biomarkers relevant to patients with myocardial infarction (MI), which is the leading cause of death in the world. Dysregulated microRNAs (miRNAs) and messenger RNAs (mRNAs) based on two Gene Expression Omnibus microarrays were analyzed using bioinformatics technology and experiments. KEGG and GO enrichment analyses were performed to explore potential mechanisms of myocardial infarction progression. Immune infiltration analysis was used to assess the relationship between the immune microenvironment and myocardial infarction. The DOX-induced myocardial injury model was used to simulate myocardial infarction. qRT-PCR was performed to validate the expression of hub genes. 5 downregulated miRNAs and 14 upregulated mRNAs were identified in total. Functional analysis revealed that some immune-related pathways were significantly enriched. T cells CD8+ were mainly enriched in the normal tissues compared to the myocardial infarction tissues. Meanwhile, the T cells CD4+ memory resting were highly enriched in the myocardial infarction tissues compared to the normal tissues. Experimental validation of miRNAs and mRNAs contributed to the identification of 4 miRNAs and 12 mRNAs that may play a crucial role in the DOX-induced myocardial infarction cell model. Our study successfully identified several genes that may be related to myocardial infarction progression.
心肌梗死(MI)是世界上主要的死亡原因,迫切需要探索和验证与心肌梗死(MI)患者相关的新型生物标志物。利用生物信息学技术和实验分析了基于两种基因表达综合微阵列的microRNAs (miRNAs)和信使rna (mrna)的失调。进行KEGG和GO富集分析以探索心肌梗死进展的潜在机制。采用免疫浸润分析评价免疫微环境与心肌梗死的关系。采用dox致心肌损伤模型模拟心肌梗死。采用qRT-PCR验证枢纽基因的表达。共鉴定出5个下调的mirna和14个上调的mrna。功能分析显示,一些免疫相关通路显著富集。与心肌梗死组织相比,T细胞CD8+主要富集于正常组织。同时,心肌梗死组织中T细胞CD4+记忆静息较正常组织高度富集。通过对mirna和mrna的实验验证,鉴定出可能在dox诱导的心肌梗死细胞模型中发挥关键作用的4种mirna和12种mrna。我们的研究成功地确定了几个可能与心肌梗死进展相关的基因。
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引用次数: 0
Key genes of inflammation and Crohn’s disease severity identified via bioinformatics and clinical specimen analysis 通过生物信息学和临床标本分析确定炎症和克罗恩病严重程度的关键基因
4区 综合性期刊 Pub Date : 2023-09-14 DOI: 10.1080/26895293.2023.2251705
Min Lu, Zhirui Zeng, Yongjian Ling, Qinsong Zhong, Zhiliang Mai, Hua Mao, Qian Wang
Crohn’s disease (CD) is a nonspecific inflammatory disease of digestive tract with limited known biomarkers. We aimed to identify potential molecules involved in CD severity. Weighted gene co-expression network and differentially expressed gene analyses were used to explore hub genes associated with inflammation and involved in pathological processes of CD in the GSE83448 cohort. The expression and relationship of genes with clinical characteristics in normal and CD intestinal mucosa were validated in GSE208303 and our research cohorts. Five genes related to disease and inflammation were identified in the clinically significant modules that were differentially expressed in healthy controls and CD patients. Among them, solute carrier family 39 member 5 (SLC39A5) expression was reduced in CD tissues compared with that in normal tissues; low SLC39A5 expression was associated with CD-simplifying endoscopic score and stenosis. Furthermore, we broadened the bioinformatic threshold with qRT-PCR verification and western blot, and found that the expressions of cytochrome P450 family 2 subfamily S member 1 (CYP2S1), fatty acid 2-hydroxylase (FA2H), fatty acid binding protein 1 (FABP1), and Rho family GTPase 3 (RND3) were reduced in CD tissues. Therefore, SLC39A5, CYP2S1, FA2H, FABP1, and RND3 may be novel biomarkers for CD and associated with severity.
克罗恩病(CD)是一种已知生物标志物有限的消化道非特异性炎症性疾病。我们的目标是确定与乳糜泻严重程度有关的潜在分子。通过加权基因共表达网络和差异表达基因分析,在GSE83448队列中探索与炎症相关并参与CD病理过程的枢纽基因。在GSE208303和我们的研究队列中验证了正常和CD肠粘膜中基因的表达及其与临床特征的关系。在健康对照组和乳糜泻患者的临床显著模块中发现了5个与疾病和炎症相关的基因的差异表达。其中,溶质载体家族39成员5 (SLC39A5)在CD组织中的表达较正常组织降低;SLC39A5低表达与cd简化内镜评分和狭窄相关。此外,我们通过qRT-PCR验证和western blot拓宽了生物信息学门槛,发现细胞色素P450家族2亚家族S成员1 (CYP2S1)、脂肪酸2-羟基化酶(FA2H)、脂肪酸结合蛋白1 (FABP1)和Rho家族GTPase 3 (RND3)在CD组织中的表达降低。因此,SLC39A5、CYP2S1、FA2H、FABP1和RND3可能是CD的新型生物标志物,并与CD的严重程度相关。
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