Pub Date : 2023-01-23DOI: 10.1080/26895293.2022.2164359
L. Fan, Jing-ling Shi, Xiaobo Yang
{"title":"Prunetin alleviates dextran sulfate sodium-induced colitis via the regulation of inflammatory response based on network pharmacology and experimental evidence","authors":"L. Fan, Jing-ling Shi, Xiaobo Yang","doi":"10.1080/26895293.2022.2164359","DOIUrl":"https://doi.org/10.1080/26895293.2022.2164359","url":null,"abstract":"","PeriodicalId":48478,"journal":{"name":"All Life","volume":"22 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84136715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Promoters play a key role in influencing transcriptional regulation for fine-tuning the expression of genes. Heterologous promoter engineering has been a widely used concept to control the level of transcription in all model organisms. The strength of a promoter is mainly determined by its nucleotide composition. Many promoter libraries have been curated, but few have attempted to develop theoretical methods to predict the strength of promoters from their nucleotide sequence. Such theoretical methods are not only valuable in the design of promoters with specified strength but are also meaningful in understanding the mechanistic role of promoters in transcriptional regulation. In this study, we present a theoretical model to describe the relationship between promoter strength and nucleotide sequence in Saccharomyces cerevisiae. We infer from our analysis that the −49–10 sequence with respect to the Transcription Start Site represents the minimal region that can be used to predict promoter strength. https://qpromoters.com/ and a standalone tool https://github.com/DevangLiya/QPromoters to quickly quantify the strength of Saccharomyces cerevisiae promoters.
{"title":"QPromoters: sequence based prediction of promoter strength in <i>Saccharomyces cerevisiae</i>","authors":"Devang Haresh Liya, Mirudula Elanchezhian, Mukulika Pahari, Nithishwer Mouroug Anand, Shivani Suresh, Nivedha Balaji, Ashwin Kumar Jainarayanan","doi":"10.1080/26895293.2023.2168304","DOIUrl":"https://doi.org/10.1080/26895293.2023.2168304","url":null,"abstract":"Promoters play a key role in influencing transcriptional regulation for fine-tuning the expression of genes. Heterologous promoter engineering has been a widely used concept to control the level of transcription in all model organisms. The strength of a promoter is mainly determined by its nucleotide composition. Many promoter libraries have been curated, but few have attempted to develop theoretical methods to predict the strength of promoters from their nucleotide sequence. Such theoretical methods are not only valuable in the design of promoters with specified strength but are also meaningful in understanding the mechanistic role of promoters in transcriptional regulation. In this study, we present a theoretical model to describe the relationship between promoter strength and nucleotide sequence in Saccharomyces cerevisiae. We infer from our analysis that the −49–10 sequence with respect to the Transcription Start Site represents the minimal region that can be used to predict promoter strength. https://qpromoters.com/ and a standalone tool https://github.com/DevangLiya/QPromoters to quickly quantify the strength of Saccharomyces cerevisiae promoters.","PeriodicalId":48478,"journal":{"name":"All Life","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134969138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-19DOI: 10.1080/26895293.2023.2167866
M. A. Nanda, K. Seminar, A. Maddu, D. Nandika
{"title":"Acoustic and temperature signals generated by subterranean termite infestation: its characteristics and implementations","authors":"M. A. Nanda, K. Seminar, A. Maddu, D. Nandika","doi":"10.1080/26895293.2023.2167866","DOIUrl":"https://doi.org/10.1080/26895293.2023.2167866","url":null,"abstract":"","PeriodicalId":48478,"journal":{"name":"All Life","volume":"7 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72908843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-19DOI: 10.1080/26895293.2023.2167872
R. Mesnage, C. Benbrook
{"title":"Use of the concept ‘environmentally relevant level’ in linking the results of pesticide toxicity studies to public health outcomes","authors":"R. Mesnage, C. Benbrook","doi":"10.1080/26895293.2023.2167872","DOIUrl":"https://doi.org/10.1080/26895293.2023.2167872","url":null,"abstract":"","PeriodicalId":48478,"journal":{"name":"All Life","volume":"23 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85608455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-19DOI: 10.1080/26895293.2023.2167867
yanshou zhang, Zhifen Yang, Chunyang Wang, Lijia Du, Yingru Liu
{"title":"Pregnancy-associated breast cancer (PABC) in young women: a matched case-control study","authors":"yanshou zhang, Zhifen Yang, Chunyang Wang, Lijia Du, Yingru Liu","doi":"10.1080/26895293.2023.2167867","DOIUrl":"https://doi.org/10.1080/26895293.2023.2167867","url":null,"abstract":"","PeriodicalId":48478,"journal":{"name":"All Life","volume":"64 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83515469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-17DOI: 10.1080/26895293.2022.2163306
Chengyang Chen, Xia Jiang, Zengren Zhao
{"title":"Inhibition or promotion, the potential role of arginine metabolism in immunotherapy for colorectal cancer","authors":"Chengyang Chen, Xia Jiang, Zengren Zhao","doi":"10.1080/26895293.2022.2163306","DOIUrl":"https://doi.org/10.1080/26895293.2022.2163306","url":null,"abstract":"","PeriodicalId":48478,"journal":{"name":"All Life","volume":"54 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91065387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-17DOI: 10.1080/26895293.2022.2163303
Berhanu Hiruy, E. Getu
{"title":"Evaluation of Calpurnia aurea leaf extracts as natural insect repellents for stored product insect pests in Ethiopia","authors":"Berhanu Hiruy, E. Getu","doi":"10.1080/26895293.2022.2163303","DOIUrl":"https://doi.org/10.1080/26895293.2022.2163303","url":null,"abstract":"","PeriodicalId":48478,"journal":{"name":"All Life","volume":"35 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81982852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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