Introduction
Stroke is one of the leading causes of morbidity and mortality globally, with a significant impact on health systems. In South Africa, especially the Eastern Cape, the epidemiology of acute stroke and the barriers to optimal care remain poorly described.
Methods
This retrospective cohort study included adult patients (≥18 years) presenting with acute stroke at a hospital in Gqeberha, Eastern Cape, from 1 July 2019 to 30 June 2020.
Results
A total of 403 patients met the inclusion criteria, with 38 excluded from time-based analysis. The median patient age was 60.4 years (IQR 51.6 – 70.6); 54 % were female. Most patients (56 %) arrived via private transport, and 58 % had radiological evidence of an ischaemic stroke. Common stroke risk factors included hypertension, diabetes, and smoking. The median time from symptom onset to hospital presentation was 06 h and 30 min; with 9 % of patients presenting with a wake-up stroke. The median door-to-doctor time was 52 min with 51.8 % seen within 60 min. The median door-to-CT time was 5 h 7 min. A higher proportion of imaging occurred after hours. 99 patients presented within the 4.5-hour thrombolytic window (hyperacute stroke). Of these, 32 had radiological evidence of an intracranial haemorrhage. In the hyperacute stroke cohort, the median door-to-doctor and door-to-CT times were shorter: 25 min and 2 h 19 min respectively. Of those with ischaemic stroke, 35 % were excluded from thrombolysis due to time related factors, 34 % had contraindications, and 31 % were not offered treatment due to clinical and physician related factors. No patients admitted via the emergency department received thrombolysis. None of the national or international time-based quality metrics for acute stroke care were met.
Conclusion
This study provides valuable insights into the region’s stroke epidemiology and identifies areas for improvement for acute stroke care.
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