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Paediatric procedural sedation and or analgesia in the emergency unit; A descriptive study of practice at a Ugandan Referral Hospital 儿科急诊科的程序性镇静和/或镇痛;对乌干达一家转诊医院实践的描述性研究
IF 1.2 4区 医学 Q3 EMERGENCY MEDICINE Pub Date : 2025-12-01 DOI: 10.1016/j.afjem.2025.100929
Anna Meridah Kaguna , John Mark Mayanja Kasumba , Mary Ellen Lyon , Jonathan Byasi , Celine Jacobs , Rachael Parke

Background

Paediatric Procedural Sedation and/ or Analgesia (PPSA) is the recommended standard of practice for children undergoing painful and distressing procedures outside the operating room; however, global practice may vary. In Sub-Saharan Africa, data on the practice of PPSA is lacking. This study aimed to determine the current practice and outcomes of PPSA in the Emergency unit of Mulago National Referral Hospital to inform future standardisation of care.

Methods

We conducted a descriptive study from 1st October to 31st December 2023 in the surgical section of the emergency unit of Mulago National Referral Hospital. Data was collected using specifically designed and pretested observational checklists, documenting demographics, pre-procedure assessment and preparation, intra-procedural and post-procedural care, average sedation scores attained, pain control and adverse events observed. Data was coded using EPI-Data and analysed to describe PPSA practice and outcomes.

Results

We recruited 183 children undergoing procedures at the surgical section of the emergency unit. Majority were male, 104(56.8 %), and the median age (IQR) was 8 (4–12)years. Most procedures performed were orthopaedic, 149(81.4 %). Only 15(8.2 %) children got both sedation and analgesia, 4(2.2 %) got sedation only while 164(89.6 %) got analgesia only. Propofol was the most used sedative, while lignocaine with paracetamol was the most used analgesia. Most children, 92(50.3 %), had pain scores ≥8, and adverse events occurred in 6(3.3 %), all of whom belonged to the sedation and analgesia group. Anaesthetic officers were the primary providers in 75 % of the sedation-only cases and 46.7 % of the sedation and analgesia group.

Conclusion

PPSA practice in this Emergency setting deviates from recommended standards with limited monitoring and inadequate pain control. The clustering of adverse events among children receiving both sedation and analgesia underscores safety risks. Safer sedative choices, clear provider roles, local guidelines, and targeted training are needed to improve the safety and quality of PPSA.
背景:儿科手术镇静和/或镇痛(PPSA)是在手术室外接受疼痛和痛苦手术的儿童的推荐实践标准;然而,全球的做法可能有所不同。在撒哈拉以南非洲,缺乏关于PPSA做法的数据。本研究旨在确定目前在穆拉戈国家转诊医院急诊科实施PPSA的做法和结果,为未来的护理标准化提供信息。方法于2023年10月1日至12月31日在穆拉戈国家转诊医院急诊科外科进行描述性研究。使用专门设计和预先测试的观察性检查表收集数据,记录人口统计学、术前评估和准备、术中和术后护理、获得的平均镇静评分、疼痛控制和观察到的不良事件。使用EPI-Data对数据进行编码,并对其进行分析,以描述PPSA的实践和结果。结果我们招募了183名在急诊科外科接受手术的儿童。多数为男性,104例(56.8%),中位年龄(IQR)为8(4-12)岁。大多数手术是矫形手术,149例(81.4%)。同时镇静和镇痛15例(8.2%),单纯镇静4例(2.2%),单纯镇痛164例(89.6%)。异丙酚是最常用的镇静剂,而利多卡因与扑热息痛是最常用的镇痛药。92例(50.3%)患儿疼痛评分≥8分,6例(3.3%)患儿发生不良事件,均属于镇静镇痛组。麻醉人员是75%的单纯镇静组和46.7%的镇静镇痛组的主要提供者。结论急诊ppsa的做法偏离了推荐的标准,监测有限,疼痛控制不足。同时接受镇静和镇痛的儿童不良事件的聚集性强调了安全风险。需要更安全的镇静剂选择、明确的提供者角色、当地指南和有针对性的培训来提高PPSA的安全性和质量。
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引用次数: 0
Assessing junior doctors' knowledge and attitude on advanced life support in Egypt: a cross-sectional study 评估初级医生对埃及晚期生命支持的知识和态度:一项横断面研究
IF 1.2 4区 医学 Q3 EMERGENCY MEDICINE Pub Date : 2025-12-01 DOI: 10.1016/j.afjem.2025.100927
Yasser Ahmed Khalid , Mohamed Bosily Saad , Mohamed Ezzat Nasreddin

Introduction

Cardiovascular diseases are a leading cause of mortality worldwide, with cardiac arrest survival heavily dependent on timely and effective resuscitation efforts. Junior doctors often serve as first responders in hospitals, yet their advanced life support (ALS) knowledge and training adequacy remain underinvestigated in Egypt. This study assessed the knowledge and attitudes of junior doctors in Egypt regarding basic life support (BLS) and ALS, identified knowledge gaps, and suggests improvements in resuscitation training programs.

Methods

A cross-sectional survey was conducted among 184 junior doctors, including house officers, general practitioners, and residents, across multiple healthcare centres in Egypt. Data was collected via an online questionnaire based on European Resuscitation Council guidelines, evaluating demographic factors, BLS/ALS knowledge, and attitudes toward cardiac arrest management. Statistical analysis explored associations between knowledge scores and participant characteristics.

Results

Participants demonstrated inadequate knowledge with mean BLS and ALS scores of 59 % and 61.8 %, respectively. Significant deficiencies were noted in pediatric resuscitation, cardiac arrest diagnosis, IV access, and capnography interpretation. Residents and those attending ALS workshops scored significantly higher (p < 0.05), while prior clinical exposure did not correlate with higher knowledge scores. Most participants (91.3%) expressed a need for further ALS training.

Discussion

Junior doctors in Egypt show deficient ALS knowledge with critical gaps that may impact patient outcomes. Structured ALS training and curriculum reforms are urgently needed to enhance emergency preparedness and improve cardiac arrest survival.
心血管疾病是世界范围内死亡的主要原因,心脏骤停的生存严重依赖于及时有效的复苏努力。初级医生通常是医院的第一响应者,但他们的高级生命支持(ALS)知识和培训充足性在埃及仍未得到充分调查。本研究评估了埃及初级医生关于基本生命支持(BLS)和ALS的知识和态度,确定了知识差距,并提出了复苏培训计划的改进建议。方法对184名初级医生进行横断面调查,包括住院医生、全科医生和住院医生,来自埃及多个医疗保健中心。数据通过基于欧洲复苏委员会指南的在线问卷收集,评估人口统计学因素、BLS/ALS知识和对心脏骤停管理的态度。统计分析探讨了知识得分与参与者特征之间的关系。结果受试者的BLS和ALS平均得分分别为59%和61.8%。在儿科复苏、心脏骤停诊断、静脉注射和血管造影解释方面存在显著缺陷。住院医师和参加ALS研讨会的患者得分显著高于其他患者(p < 0.05),而先前的临床暴露与更高的知识得分无关。大多数参与者(91.3%)表示需要进一步的ALS培训。讨论埃及的初级医生对渐冻症的了解不足,存在可能影响患者预后的严重差距。迫切需要结构化的ALS培训和课程改革,以加强应急准备和提高心脏骤停存活率。
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引用次数: 0
Prehospital care utilization and associated factors among trauma patients during armed conflict: A mixed-methods study in west Amhara, Ethiopia referral hospitals 武装冲突期间创伤患者院前护理的利用及其相关因素:埃塞俄比亚西阿姆哈拉转诊医院的混合方法研究
IF 1.2 4区 医学 Q3 EMERGENCY MEDICINE Pub Date : 2025-12-01 DOI: 10.1016/j.afjem.2025.100931
Temesgen Ayenew , Mengistu Abebe Messelu , Haile Amha , Mamaru Getie Fetene , Fentahun Minwuyelet Yitayew , Anteneh Belayneh , Abere Kassie , Getinet Nibret , Bekele Getenet Tiruneh

Background

Prehospital care is vital for reducing mortality from traumatic injuries, especially in low- and middle-income countries. This study determined prehospital care utilization and associated factors among trauma patients in referral hospitals in West Amhara, Ethiopia.

Methods

A concurrent triangulation mixed-methods design was employed from March–August 2024 in Debre Markos, Tibebe Ghion, and Felege Hiwot hospitals. Quantitative data were collected from 518 trauma patients via questionnaire, with proportional allocation based on patient flow, and analyzed using logistic regression to identify factors associated with prehospital care use. Qualitative data were collected through semi-structured interviews with healthcare professionals and trauma patients, reported in line with the Consolidated criteria for reporting qualitative research (COREQ) checklist. Reflexive thematic analysis guided by the WHO Emergency Care System Framework was used, integrating quantitative and qualitative findings while maintaining reflexivity to understand prehospital care utilization.

Results

The prehospital care utilization rate was 49.8 %. The majority of patients (84.2 %) arrived at hospitals via taxi or on foot, reflecting reliance on non-EMS transport. Rural residence (AOR = 4.80), lower education (AOR = 0.54), violence/quarrel-related injuries (AOR = 2.60), motor vehicle accidents (AOR = 2.00), gunshot injuries (AOR = 8.61), and penetrating injuries (AOR = 0.34) were significantly associated with prehospital care use.

Qualitative findings revealed challenges across four themes

Limited awareness and lack of emergency communication systems during initial contact and dispatch (Scene); scarce ambulances, long response times, and reliance on non-EMS transport in prehospital treatment and transportation (Transport); resource and personnel shortages that indirectly affect prehospital response within facility-based emergency care linkages (Facility); and the need for Advocacy and Public Education.

Conclusion

Prehospital care utilization is sub-optimal, influenced by sociodemographic and injury-related factors. Qualitative insights reveal systemic and community challenges that warrant further investigation through larger, more representative studies.
院前护理对于降低外伤死亡率至关重要,特别是在低收入和中等收入国家。本研究确定了在西阿姆哈拉,埃塞俄比亚转诊医院创伤患者院前护理的利用和相关因素。方法于2024年3 - 8月在Debre Markos、Tibebe gion和freelege Hiwot医院采用并行三角测量混合方法设计。采用问卷调查的方式收集518例创伤患者的定量数据,根据患者流量进行比例分配,并采用logistic回归分析确定院前护理使用的相关因素。通过对医疗保健专业人员和创伤患者的半结构化访谈收集定性数据,并根据定性研究报告综合标准(COREQ)清单进行报告。采用了以世卫组织紧急护理系统框架为指导的反思性专题分析,在保持反思性的同时整合定量和定性研究结果,以了解院前护理的利用情况。结果院前护理使用率为49.8%。大多数患者(84.2%)通过出租车或步行到达医院,反映了对非ems运输的依赖。农村居民(AOR = 4.80)、低学历(AOR = 0.54)、暴力/争吵伤害(AOR = 2.60)、机动车事故(AOR = 2.00)、枪伤(AOR = 8.61)、穿透伤(AOR = 0.34)与院前护理使用显著相关。定性调查结果揭示了四个主题的挑战:在最初接触和调度期间,意识有限,缺乏应急通信系统(现场);救护车稀少,反应时间长,院前治疗和运输依赖非ems运输(transport);资源和人员短缺间接影响到以设施为基础的急救联系中的院前反应(设施);以及宣传和公共教育的必要性。结论院前护理利用不理想,受社会人口学和伤害相关因素的影响。定性的见解揭示了系统性和社区的挑战,需要通过更大、更有代表性的研究进行进一步的调查。
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引用次数: 0
Evaluating the availability, effectiveness, and impact of primary trauma care training in Sub-Saharan Africa: A comprehensive review 评估撒哈拉以南非洲初级创伤护理培训的可得性、有效性和影响:一项全面审查
IF 1.2 4区 医学 Q3 EMERGENCY MEDICINE Pub Date : 2025-12-01 DOI: 10.1016/j.afjem.2025.03.003
Cherinet Osebo , Tarek Razek , Victoria Munthali , Respicious Boniface

Background

Trauma is a leading cause of morbidity and mortality in sub-Saharan Africa (SSA), contributing to over 90 % of global injury-related deaths. Limited healthcare infrastructure, insufficient access to skilled healthcare professionals, and resource constraints exacerbate the trauma burden. While Advanced Trauma Life Support (ATLS) has demonstrated effectiveness in high-income settings, its high cost and limited adaptability make it less feasible in SSA. The Primary Trauma Care (PTC) course offers a cost-effective and context-appropriate alternative to ATLS. However, its implementation and impact in SSA remain underexplored. This review evaluates the availability, effectiveness, impact, and affordability of PTC courses in SSA.

Methods

A comprehensive literature review was conducted across Medline, PubMed, Embase, and African Journals Online to identify studies on PTC training in SSA. Studies examining PTC's impact on injury management, knowledge, skills, patient outcomes, and cost-effectiveness were included. Inclusion criteria focused on studies conducted between 2000 and 2024 in SSA, with a focus on PTC implementation.

Results

Four published PTC training studies were identified in both urban and rural settings across SSA, highlighting significant underutilization due to limited funding, infrastructure challenges, and insufficient institutional support. Among 2758 trainees, the majority were nurses (1625, 58.9 %) and clinical officers (1624, 58.8 %), followed by physicians (979, 35.5 %) and medical students (155, 5.6 %). Three studies demonstrated significant improvements in participants' knowledge, confidence, and skills. One study reported a reduction in trauma-related mortality rates. However, only one study directly assessed patient outcomes, indicating a gap in evaluating long-term impacts.

Conclusion

To the best of our knowledge, this is the first comprehensive review of PTC training in SSA, offering novel insights into its effectiveness and addressing critical gaps in trauma care research for resource-limited settings. The findings demonstrate that PTC significantly enhances trauma care knowledge, confidence, and departmental capacity, making it a cost-effective and scalable training program for resource-constrained settings. However, the limited scope and frequency of PTC courses call for policymakers to prioritize expanding access to these programs and integrating them into national trauma care strategies. Collaborative efforts are needed to secure funding, increase institutional support, and conduct more institution-based studies to evaluate the long-term impact of PTC on patient outcomes, morbidity, and quality of life in SSA.
背景创伤是撒哈拉以南非洲(SSA)发病率和死亡率的主要原因,占全球伤害相关死亡的90%以上。有限的医疗基础设施、缺乏获得熟练医疗保健专业人员的机会以及资源限制加剧了创伤负担。虽然高级创伤生命支持(ATLS)在高收入环境中已证明有效,但其高成本和有限的适应性使其在SSA中不太可行。初级创伤护理(PTC)课程为ATLS提供了一种具有成本效益和适合情境的替代方案。然而,它的实施和对南南合作的影响仍未得到充分探讨。本综述评估了PTC课程在SSA的可用性、有效性、影响和可负担性。方法通过Medline、PubMed、Embase和African Journals Online进行综合文献综述,以确定SSA中PTC培训的研究。研究包括检查PTC对损伤管理、知识、技能、患者预后和成本效益的影响。纳入标准侧重于2000年至2024年间在SSA进行的研究,重点是PTC的实施。结果在SSA的城市和农村环境中确定了四项已发表的PTC培训研究,突出了由于资金有限、基础设施挑战和机构支持不足而导致的严重利用不足。在2758名受训人员中,大多数是护士(1625人,58.9%)和临床医生(1624人,58.8%),其次是医生(979人,35.5%)和医学生(155人,5.6%)。三项研究表明,参与者的知识、信心和技能都有了显著提高。一项研究报告了创伤相关死亡率的降低。然而,只有一项研究直接评估了患者的预后,表明在评估长期影响方面存在差距。据我们所知,这是第一次对SSA中PTC培训的全面回顾,为其有效性提供了新的见解,并解决了资源有限环境下创伤护理研究的关键空白。研究结果表明,PTC显著提高创伤护理知识、信心和部门能力,使其成为资源受限环境下具有成本效益和可扩展的培训计划。然而,PTC课程的范围和频率有限,这要求决策者优先考虑扩大这些课程的使用范围,并将其纳入国家创伤护理战略。需要合作努力来确保资金,增加机构支持,并开展更多基于机构的研究,以评估PTC对SSA患者结局、发病率和生活质量的长期影响。
{"title":"Evaluating the availability, effectiveness, and impact of primary trauma care training in Sub-Saharan Africa: A comprehensive review","authors":"Cherinet Osebo ,&nbsp;Tarek Razek ,&nbsp;Victoria Munthali ,&nbsp;Respicious Boniface","doi":"10.1016/j.afjem.2025.03.003","DOIUrl":"10.1016/j.afjem.2025.03.003","url":null,"abstract":"<div><h3>Background</h3><div>Trauma is a leading cause of morbidity and mortality in sub-Saharan Africa (SSA), contributing to over 90 % of global injury-related deaths. Limited healthcare infrastructure, insufficient access to skilled healthcare professionals, and resource constraints exacerbate the trauma burden. While Advanced Trauma Life Support (ATLS) has demonstrated effectiveness in high-income settings, its high cost and limited adaptability make it less feasible in SSA. The Primary Trauma Care (PTC) course offers a cost-effective and context-appropriate alternative to ATLS. However, its implementation and impact in SSA remain underexplored. This review evaluates the availability, effectiveness, impact, and affordability of PTC courses in SSA.</div></div><div><h3>Methods</h3><div>A comprehensive literature review was conducted across Medline, PubMed, Embase, and African Journals Online to identify studies on PTC training in SSA. Studies examining PTC's impact on injury management, knowledge, skills, patient outcomes, and cost-effectiveness were included. Inclusion criteria focused on studies conducted between 2000 and 2024 in SSA, with a focus on PTC implementation.</div></div><div><h3>Results</h3><div>Four published PTC training studies were identified in both urban and rural settings across SSA, highlighting significant underutilization due to limited funding, infrastructure challenges, and insufficient institutional support. Among 2758 trainees, the majority were nurses (1625, 58.9 %) and clinical officers (1624, 58.8 %), followed by physicians (979, 35.5 %) and medical students (155, 5.6 %). Three studies demonstrated significant improvements in participants' knowledge, confidence, and skills. One study reported a reduction in trauma-related mortality rates. However, only one study directly assessed patient outcomes, indicating a gap in evaluating long-term impacts.</div></div><div><h3>Conclusion</h3><div>To the best of our knowledge, this is the first comprehensive review of PTC training in SSA, offering novel insights into its effectiveness and addressing critical gaps in trauma care research for resource-limited settings. The findings demonstrate that PTC significantly enhances trauma care knowledge, confidence, and departmental capacity, making it a cost-effective and scalable training program for resource-constrained settings. However, the limited scope and frequency of PTC courses call for policymakers to prioritize expanding access to these programs and integrating them into national trauma care strategies. Collaborative efforts are needed to secure funding, increase institutional support, and conduct more institution-based studies to evaluate the long-term impact of PTC on patient outcomes, morbidity, and quality of life in SSA.</div></div>","PeriodicalId":48515,"journal":{"name":"African Journal of Emergency Medicine","volume":"15 4","pages":"Article 100872"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial - AfJEM Dec 2025 社论- AfJEM 2025年12月
IF 1.2 4区 医学 Q3 EMERGENCY MEDICINE Pub Date : 2025-12-01 DOI: 10.1016/j.afjem.2025.100930
{"title":"Editorial - AfJEM Dec 2025","authors":"","doi":"10.1016/j.afjem.2025.100930","DOIUrl":"10.1016/j.afjem.2025.100930","url":null,"abstract":"","PeriodicalId":48515,"journal":{"name":"African Journal of Emergency Medicine","volume":"15 4","pages":"Article 100930"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Service utilisation and outcomes of transfers by a specialised paediatric and neonatal retrieval service in the Western Cape, South Africa 服务利用和转移的结果由专门的儿科和新生儿检索服务在西开普省,南非
IF 1.2 4区 医学 Q3 EMERGENCY MEDICINE Pub Date : 2025-11-21 DOI: 10.1016/j.afjem.2025.100925
Shama Patel , Liezl Smit , Grant Felix , Baljit Cheema , Andrew Redfern

Introduction

Development of emergency care systems and provision of quality pre-hospital care have been identified as a priority to reduce childhood morbidity and mortality in low-resource settings. A dedicated paediatric and neonatal retrieval transfer team (SPRINTT) service was established in the Western Cape, South Africa, in 2016. This study describes the utilisation of Emergency Medical Services (EMS) for children and neonates identified as requiring SPRINTT. Additionally, the indications, clinical profile, and outcomes for a sub-group of children transferred to a tertiary paediatric emergency department (PED) are described.

Methods

This retrospective study reviewed cases requiring SPRINTT from November 2019 to November 2020. Data were obtained from EMS Electronic Patient Care Records (ePCR) and Computer Aided Dispatch (CAD) databases. A sub-group of cases transferred to a tertiary PED were reviewed using hospital records.

Results

A total of 2361 inter-facility transfers logged as SPRINTT incident-types occurred during the study period, with 54% being neonates <29 days. The majority (87%) were from urban facilities. Most cases (82%) were high acuity, being triaged as an emergency or very urgent. Of the sub-group of 203 cases transferred to the PED, acute respiratory illnesses (42%) and gastroenteritis (24%) were the most frequent presenting complaints. Eight children (4%) died, and 16% of children were unstable on arrival. Cardiovascular instability and escalation of respiratory support within 60 min of PED arrival were associated with PICU admission and death (p < 0.001).

Conclusion

This study is the first description of the utilisation of the SPRINTT service that includes a description of patient outcomes. The large number of SPRINT-type transfers reflects the considerable burden of acutely ill paediatric and neonatal cases and highlights the need for specialised pre-hospital care services. For the PED sub-group, 84% were stable on arrival suggesting that the retrieval service performs an important role in pre-hospital care and transfer in this setting.
急诊护理系统的发展和提供高质量的院前护理已被确定为在低资源环境中降低儿童发病率和死亡率的优先事项。2016年,在南非西开普省成立了专门的儿科和新生儿检索转移小组(SPRINTT)服务。本研究描述了紧急医疗服务(EMS)对确定需要SPRINTT的儿童和新生儿的利用情况。此外,对转入三级儿科急诊科(PED)的儿童亚组的适应症、临床概况和结果进行了描述。方法回顾性分析2019年11月至2020年11月期间需要sprint治疗的病例。数据来自EMS电子病人护理记录(ePCR)和计算机辅助调度(CAD)数据库。一个亚组的病例转移到三级PED审查使用医院记录。结果在研究期间共发生2361例SPRINTT事件类型的医院间转移,其中54%为29天的新生儿。大多数(87%)来自城市设施。大多数病例(82%)是高视力,被分类为紧急或非常紧急。在转入PED的203例亚组中,急性呼吸道疾病(42%)和肠胃炎(24%)是最常见的主诉。8名儿童(4%)死亡,16%的儿童在抵达时情况不稳定。PED到达后60分钟内心血管不稳定和呼吸支持升级与PICU入院和死亡相关(p < 0.001)。结论:本研究首次描述了SPRINTT服务的使用情况,其中包括对患者结果的描述。大量的sprint型转诊反映了急性儿科和新生儿病例的巨大负担,并突出了对专门院前护理服务的需要。对于PED亚组,84%的患者在到达时病情稳定,这表明检索服务在这种情况下的院前护理和转院中发挥了重要作用。
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引用次数: 0
Clinical profile and outcome of patients with acute kidney injury in the Emergency Department of a teaching hospital in Ethiopia 埃塞俄比亚一家教学医院急诊科急性肾损伤患者的临床概况和预后
IF 1.2 4区 医学 Q3 EMERGENCY MEDICINE Pub Date : 2025-11-21 DOI: 10.1016/j.afjem.2025.100926
Berihu Assefa Berhe , Benyam Bahta Gebrehiwot , Frehiwot Worku Senbeta , Dirijit Mamo Alemu , Menbeu Sultan Mohammed , Mohammed Kalifa Nuguse , Yemane Gebremedhin Tesfay

Background

Acute Kidney Injury (AKI) affects 13.3 million people annually, with 85% in low resource settings. This study aimed to identify AKI profiles and outcomes in Ethiopia's largest teaching hospital's emergency department, focusing on targeted therapy and preventative measures.

Method and Materials

A cross-sectional study was conducted at an Ethiopian teaching hospital's Emergency Department from June 1, 2021, to June 1, 2022. Descriptive statistics and binary logistic regression were analyzed. A paired samples T-test was used to compare patient findings.

Results

Among the 222 AKI patients included in the study, 110 (49.5 %) were males, and 112 (50.5 %) were females. The mean age of presentation was 48±18 years old. Most patients were from Addis Ababa (41.4 %) and the Oromia region (40.5 %). The most common causes of AKI were infections (26.2 %), acute glomerulonephritis (20.4 %), volume depletion (18.5 %), and obstructive uropathy (16.6 %). Uremic encephalopathy, infection, malignancy, and a low initial Glasgow Coma Scale significantly contributed to unfavorable outcomes. The presence of nephrotoxic antibiotics, infection, and hyponatremia significantly contributed to the admission rate to the wards and intensive care unit.

Conclusion

In conclusion, infection is the dominant cause and mortality predictor of AKI. The majority of patients with infections were sepsis (78.1 %), pyelonephritis (11.4 %), and pneumonia (10.3 %). Early initiation of antibiotics in the Emergency Department contributes to improved outcomes.
背景:急性肾损伤(AKI)每年影响1330万人,其中85%发生在资源匮乏地区。本研究旨在确定埃塞俄比亚最大的教学医院急诊科的AKI概况和结果,重点是靶向治疗和预防措施。方法与材料于2021年6月1日至2022年6月1日在埃塞俄比亚一家教学医院急诊科进行了一项横断面研究。描述性统计和二元逻辑回归分析。配对样本t检验用于比较患者的结果。结果222例AKI患者中,男性110例(49.5%),女性112例(50.5%)。平均发病年龄48±18岁。大多数患者来自亚的斯亚贝巴(41.4%)和奥罗米亚地区(40.5%)。AKI最常见的原因是感染(26.2%),急性肾小球肾炎(20.4%),容量耗竭(18.5%)和梗阻性尿病(16.6%)。尿毒症脑病、感染、恶性肿瘤和较低的初始格拉斯哥昏迷评分显著导致不良结果。肾毒性抗生素、感染和低钠血症的存在显著增加了病房和重症监护病房的入院率。结论感染是AKI的主要病因和死亡预测因子。感染主要为败血症(78.1%)、肾盂肾炎(11.4%)和肺炎(10.3%)。在急诊科早期使用抗生素有助于改善预后。
{"title":"Clinical profile and outcome of patients with acute kidney injury in the Emergency Department of a teaching hospital in Ethiopia","authors":"Berihu Assefa Berhe ,&nbsp;Benyam Bahta Gebrehiwot ,&nbsp;Frehiwot Worku Senbeta ,&nbsp;Dirijit Mamo Alemu ,&nbsp;Menbeu Sultan Mohammed ,&nbsp;Mohammed Kalifa Nuguse ,&nbsp;Yemane Gebremedhin Tesfay","doi":"10.1016/j.afjem.2025.100926","DOIUrl":"10.1016/j.afjem.2025.100926","url":null,"abstract":"<div><h3>Background</h3><div>Acute Kidney Injury (AKI) affects 13.3 million people annually, with 85% in low resource settings. This study aimed to identify AKI profiles and outcomes in Ethiopia's largest teaching hospital's emergency department, focusing on targeted therapy and preventative measures.</div></div><div><h3>Method and Materials</h3><div>A cross-sectional study was conducted at an Ethiopian teaching hospital's Emergency Department from June 1, 2021, to June 1, 2022. Descriptive statistics and binary logistic regression were analyzed. A paired samples T-test was used to compare patient findings.</div></div><div><h3>Results</h3><div>Among the 222 AKI patients included in the study, 110 (49.5 %) were males, and 112 (50.5 %) were females. The mean age of presentation was 48±18 years old. Most patients were from Addis Ababa (41.4 %) and the Oromia region (40.5 %). The most common causes of AKI were infections (26.2 %), acute glomerulonephritis (20.4 %), volume depletion (18.5 %), and obstructive uropathy (16.6 %). Uremic encephalopathy, infection, malignancy, and a low initial Glasgow Coma Scale significantly contributed to unfavorable outcomes. The presence of nephrotoxic antibiotics, infection, and hyponatremia significantly contributed to the admission rate to the wards and intensive care unit.</div></div><div><h3>Conclusion</h3><div>In conclusion, infection is the dominant cause and mortality predictor of AKI. The majority of patients with infections were sepsis (78.1 %), pyelonephritis (11.4 %), and pneumonia (10.3 %). Early initiation of antibiotics in the Emergency Department contributes to improved outcomes.</div></div>","PeriodicalId":48515,"journal":{"name":"African Journal of Emergency Medicine","volume":"15 4","pages":"Article 100926"},"PeriodicalIF":1.2,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145579052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global Health research abstracts: July ‘25 全球健康研究摘要:25年7月
IF 1.2 4区 医学 Q3 EMERGENCY MEDICINE Pub Date : 2025-11-20 DOI: 10.1016/j.afjem.2025.100924
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引用次数: 0
Global Health research abstracts: November ‘25 全球健康研究摘要:25年11月
IF 1.2 4区 医学 Q3 EMERGENCY MEDICINE Pub Date : 2025-11-20 DOI: 10.1016/j.afjem.2025.100921
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引用次数: 0
Global Health research abstracts: September ‘25 全球健康研究摘要:25年9月
IF 1.2 4区 医学 Q3 EMERGENCY MEDICINE Pub Date : 2025-11-20 DOI: 10.1016/j.afjem.2025.100923
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引用次数: 0
期刊
African Journal of Emergency Medicine
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