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Insomnia in pregnancy: Possible associations with birth spacing, family functioning, and spousal age difference in a Nigerian population. 妊娠期失眠:尼日利亚人口中与生育间隔、家庭功能和配偶年龄差异的可能关联
IF 3.4 2区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2026-02-01 Epub Date: 2025-11-20 DOI: 10.1016/j.sleh.2025.10.006
Michael B Fawale, Isiaka A Ismaila, Abubakar A Kulima, Adekunle Mustapha

Objectives: This study aimed to characterize insomnia and determine its associations in a sub-Saharan African population of pregnant women.

Methods: Insomnia was assessed using the Women's Health Initiative Insomnia Scale in an antenatal clinic sample of 310 pregnant women. They were screened for anxiety and depressive symptoms using the 4-item Patient Health Questionnaire and health-related quality of life was evaluated using SF-12. The participant's perception of family functioning was assessed using the Family APGAR scale. Sociodemographic, obstetric, and clinical data were collected along with blood and urine samples for hematocrit and urinary protein, respectively. Ethical clearance was obtained from the Yobe State Health Research Ethical Committee. Data analysis was performed with the SPSS software (SPSS, version 16.0), with a p value of <.05 considered statistically significant.

Results: The Women's Health Initiative Insomnia Scale identified 42.9% of our sample of pregnant women experienced insomnia. The prevalence of insomnia increased significantly from 33.7% in the second trimester to 47.1% in the third trimester. Factors independently associated with higher odds of insomnia in pregnancy were advancing gestation, poorer family functioning, having a child under 2 years, and smaller spousal age differences.

Conclusions: This study found that insomnia in pregnancy is common and is linked to advancing gestational age, short child spacing, family dysfunction, and smaller spousal age difference. The findings highlight the importance of promoting adequate child spacing and addressing family dynamics to support better sleep health in pregnant women.

目的:本研究旨在描述撒哈拉以南非洲孕妇的失眠特征并确定其相关性。方法:采用妇女健康倡议失眠量表对310名产前门诊孕妇进行失眠症评估。使用4项患者健康问卷筛查他们的焦虑和抑郁症状,并使用SF-12评估与健康相关的生活质量。使用家庭APGAR量表评估参与者对家庭功能的感知。收集社会人口学、产科和临床资料,以及血液和尿液样本,分别检测红细胞压积和尿蛋白。已获得约贝州卫生研究伦理委员会的伦理许可。使用SPSS软件(SPSS, version 16.0)进行数据分析,p值为结果:妇女健康倡议失眠量表确定42.9%的孕妇有失眠经历。失眠的患病率从妊娠中期的33.7%上升到妊娠晚期的47.1%。与妊娠期失眠几率较高相关的独立因素有妊娠期提前、家庭功能较差、孩子不满两岁以及配偶年龄差异较小。结论:本研究发现孕期失眠很常见,与胎龄提前、生育间隔短、家庭功能障碍和配偶年龄差距小有关。研究结果强调了促进适当的生育间隔和处理家庭动态以支持孕妇更好的睡眠健康的重要性。
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引用次数: 0
Monitoring sleep duration, timing, and continuity among US youth and adults in NHANES using actigraphy. 使用活动记录仪监测NHANES中美国青少年和成人的睡眠持续时间、时间和连续性。
IF 3.4 2区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2026-02-01 Epub Date: 2025-11-20 DOI: 10.1016/j.sleh.2025.10.008
Joshua R Freeman, Jennifer Zink, Marissa M Shams-White, Dana L Wolff-Hughes, Wayne R Lawrence, Samuel R LaMunion, Daniel E Russ, Jonas S Almeida, Hyokyoung G Hong, Hayden A Hayes, Pedro F Saint-Maurice, Charles E Matthews

Objectives: Sleep health differs across the life course and by sex, poverty-income ratio (PIR), and race and ethnicity. Monitoring sleep is important for informing interventions to improve sleep heath. Our objective was to explore and describe sleep characteristics among a nationally-representative US sample by age, sex, PIR, and race and ethnicity.

Methods: Data came from n=13,656 US residents aged 3-80 years in the National Health and Nutrition Examination Survey (2011-2014). Participants wore an ActiGraph GT3X+ on their wrist for ≤7 days to assess sleep. We used GGIR (v. 3.0.0) to derive sleep duration, sleep onset, sleep midpoint, waketime, wake after sleep onset (WASO), and social jetlag. Participant characteristics were self-reported. Statistical analyses were performed using SAS v. 9.4 (SAS Institute Inc., Cary, NC) and accounted for complex sampling designs. We used Time-Varying Effect Models to model sleep by age.

Results: Sleep duration was shorter with greater age. Sleep onset, midpoint, and waketime were latest among those aged 10-30 years. Social jetlag followed a similar distribution. WASO was highest among children and was lower with greater age. Females generally slept more than males. Adults with low PIR tended to have worse sleep compared with adults with higher PIR. Compared with Non-Hispanic White adults, Hispanic, Non-Hispanic Asian, and Non-Hispanic Black adults had shorter sleep duration and higher WASO. Non-Hispanic Black adults had the highest social jetlag.

Conclusions: We described sleep health in the US, including relevant population subgroups. These findings may help prioritize public health interventions to improve sleep health.

目的:睡眠健康在整个生命过程中以及在性别、贫困收入比(PIR)、种族和民族方面存在差异。监测睡眠对于告知干预措施以改善睡眠健康非常重要。我们的目的是根据年龄、性别、PIR、种族和民族来探索和描述具有全国代表性的美国样本的睡眠特征。方法:数据来自2011-2014年全国健康与营养检查调查中n=13,656名3-80岁的美国居民。参与者在手腕上佩戴ActiGraph GT3X+不超过7天来评估睡眠。我们使用GGIR (v. 3.0.0)得出睡眠持续时间、睡眠开始、睡眠中点、醒来时间、睡眠开始后醒来(WASO)和社交时差。参与者的特征是自我报告的。采用SAS v. 9.4 (SAS Institute Inc., Cary, NC)进行统计分析,并考虑到复杂的抽样设计。我们使用时变效应模型来模拟年龄的睡眠。结果:年龄越大,睡眠时间越短。10-30岁人群的睡眠开始时间、中点时间和醒时时间最晚。社交时差也有类似的分布。WASO在儿童中最高,随着年龄的增长而降低。雌性通常比雄性睡得多。与高PIR的成年人相比,低PIR的成年人往往睡眠更差。与非西班牙裔白人成年人相比,西班牙裔、非西班牙裔亚裔和非西班牙裔黑人成年人的睡眠时间较短,WASO较高。非西班牙裔黑人成年人的社交时差最高。结论:我们描述了美国的睡眠健康状况,包括相关的人群亚组。这些发现可能有助于优先考虑公共卫生干预措施,以改善睡眠健康。
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引用次数: 0
Circadian rest-activity rhythms and physical function in community-dwelling older men: The MrOS sleep study. 居住在社区的老年男性的昼夜休息-活动节律和身体功能:磁共振睡眠研究。
IF 3.4 2区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2026-02-01 Epub Date: 2025-11-11 DOI: 10.1016/j.sleh.2025.10.005
Yujia Susanna Qiao, Terri Blackwell, Dorothy M Chen, Jamie M Zeitzer, Sonia Ancoli-Israel, Alexander B Posner, Susan Redline, Gregory J Tranah, Kristine Yaffe, Katie L Stone

Objectives: Circadian rest-activity rhythms (RARs) reflect ones' physical activity and sleep patterns over the 24-hour day, correlating with cardiometabolic risk, fall risk, and cognitive decline. Physical function also declines with advancing age, leading to disability and increased risk of mortality. Thus, we examined the associations between rest-activity rhythms and physical function in older men.

Methods: In the Osteoporotic Fractures in Men (MrOS) study, 2924 men (age = 76.3±5.5 years old, 90% white) completed the sleep ancillary study (baseline) with valid wrist-worn accelerometry data and physical function measures. Physical function measures included the following: 6-meter gait speed, chair stand speed, and grip strength, assessed at baseline and up to 4 follow-up visits over 6.4±3.9 years. Using 3 approaches to quantify rest-activity rhythms (functional principal components analysis, parametric, and non-parametric approaches), we evaluated cross-sectional and longitudinal associations between baseline rest-activity rhythm patterns and decline in physical function using mixed-effects models, adjusting for demographic, lifestyle, and medical covariates.

Results: Less strength of rest-activity rhythm (ie, principal component 1, amplitude, and relative amplitude) and lower regularity (pseudo-F statistic) were both cross-sectionally and longitudinally associated with poorer physical function, particularly with gait speed and chair stand speed. Yet, significant associations between timing-related rest-activity rhythm exposures and chair stand speed were only observed cross-sectionally. Overall, the magnitude of associations differed slightly across rest-activity rhythm estimation approaches and more substantially by physical function measures.

Conclusions: Rest-activity rhythms might be a potential risk modifiable factor to target for intervention in future studies if aiming to maintain better physical function, particularly lower extremity function.

目的:昼夜休息-活动节律(RARs)反映了一个人在24小时内的身体活动和睡眠模式,与心脏代谢风险、跌倒风险和认知能力下降相关。身体机能也会随着年龄的增长而下降,从而导致残疾和死亡风险的增加。因此,我们研究了老年男性休息-活动节律与身体功能之间的关系。方法:在男性骨质疏松性骨折(MrOS)研究中,2924名男性(年龄= 76.3±5.5岁,90%为白人)通过有效的腕带加速度计数据和身体功能测量完成了睡眠辅助研究(基线)。身体功能测量包括:6米步态速度、椅子站立速度和握力,在基线和4次随访(6.4±3.9年)时进行评估。使用3种方法来量化休息-活动节律(功能主成分分析、参数和非参数方法),我们使用混合效应模型评估了基线休息-活动节律模式与身体功能下降之间的横断面和纵向关联,调整了人口统计学、生活方式和医学协变量。结果:静息-活动节律强度(即主成分1、振幅和相对振幅)和规律性(伪f统计量)较低在横断面和纵向上都与较差的身体功能相关,尤其是与步态速度和站立速度相关。然而,时间相关的休息-活动节奏暴露与椅子站立速度之间的显著关联仅在横断面上观察到。总的来说,休息-活动节律估计方法之间的关联程度略有不同,而身体功能测量方法之间的关联程度更大。结论:静息-活动节律可能是未来研究中干预的潜在危险因素,如果目标是保持更好的身体功能,特别是下肢功能。
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引用次数: 0
Multidimensional sleep patterns and microvascular complications in type 2 diabetes: Methodological perspective. 多维睡眠模式与2型糖尿病微血管并发症:方法学视角
IF 3.4 2区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2026-02-01 Epub Date: 2025-11-01 DOI: 10.1016/j.sleh.2025.10.002
Jiayi Xu, Hanning Song, Lingtian Weng, Xuhong Jiang
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引用次数: 0
Associations between community violence and pediatric sleep health: A systematic review. 社区暴力与儿童睡眠健康之间的关系:一项系统综述。
IF 3.4 2区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2026-02-01 Epub Date: 2025-11-25 DOI: 10.1016/j.sleh.2025.10.009
Hannah R Scheibner, Eileen M Condon, Kelley A LaFleur, Nancy S Redeker

Inadequate sleep during childhood can have a lasting negative impact on lifelong health. Children living in disadvantaged neighborhoods are more likely to be exposed to community violence, which may disrupt sleep health. The purpose of this systematic review was to examine the associations between community violence and pediatric sleep health. We searched 4 electronic databases (CINAHL, Scopus, PubMed, and Embase) to identify articles that examined the associations between community violence and pediatric sleep health. We screened 2271 articles and included 29 eligible studies. Studies focused on sleep quality (n = 4), daytime sleepiness (n = 8), sleep timing (n = 4), sleep efficiency (n = 7), duration (n = 13), and sleep disturbance (n = 19). Most studies included adolescents (n = 18); others included infants (n = 1), those in early childhood (n = 2), and a wide range of ages (n = 7). Six studies were of fair quality, while 5 were of poor quality, often due to the use of measures that were not psychometrically sound and incomplete sample descriptions. Community violence exposure was consistently negatively associated with pediatric sleep health. Consistent definitions and measures of sleep and community violence are needed to promote rigor and comparisons across studies. Future studies should include infants and children under the age of 6 years and address potential risk and protective factors for sleep health. Research is needed to inform policy changes and multilevel community-based interventions to help buffer the harmful effects of community violence and promote pediatric sleep health.

儿童时期睡眠不足会对一生的健康产生持久的负面影响。生活在弱势社区的儿童更有可能遭受社区暴力,这可能会破坏睡眠健康。本系统综述的目的是研究社区暴力与儿童睡眠健康之间的关系。我们检索了4个电子数据库(CINAHL、Scopus、PubMed和Embase),以确定研究社区暴力与儿童睡眠健康之间关系的文章。我们筛选了2271篇文章,包括29项符合条件的研究。研究重点是睡眠质量(n = 4)、白天嗜睡(n = 8)、睡眠时间(n = 4)、睡眠效率(n = 7)、持续时间(n = 13)和睡眠障碍(n = 19)。大多数研究包括青少年(n = 18);其他包括婴儿(n = 1),儿童早期(n = 2)和广泛的年龄范围(n = 7)。6项研究质量尚可,而5项质量较差,通常是由于使用的测量方法在心理测量学上不合理和样本描述不完整。社区暴力暴露始终与儿童睡眠健康呈负相关。需要对睡眠和社区暴力进行一致的定义和衡量,以促进研究的严谨性和比较。未来的研究应包括婴儿和6岁以下的儿童,并解决睡眠健康的潜在风险和保护因素。需要进行研究,为政策变化和多层次社区干预提供信息,以帮助缓冲社区暴力的有害影响,促进儿童睡眠健康。
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引用次数: 0
Drowsy driving prevention: A National Sleep Foundation position statement and call to action. 预防疲劳驾驶:国家睡眠基金会的立场声明和行动呼吁。
IF 3.4 2区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2026-02-01 Epub Date: 2025-11-12 DOI: 10.1016/j.sleh.2025.10.007
Joseph M Dzierzewski, Spencer A Nielson, J Todd Arnedt, Kyla Hagan-Haynes, Steven E Lerman, John Lopos, Mark R Rosekind, Brian Tefft, Imelda Wong

Drowsy driving is a prevalent form of impaired driving at the intersection of sleep health and public safety. While drowsiness has been implicated in up to 21% of motor vehicle crash fatalities, drowsy driving is largely preventable, primarily by allowing for adequate sleep opportunity and obtaining sufficient healthy sleep. National Sleep Foundation calls for targeted actions from a broad range of community members to improve public sleep health and road safety. Combating drowsy driving requires a comprehensive and coordinated approach across drivers, educators, government policy makers, healthcare professionals, industry, labor representatives, employers, and law enforcement. Actions that can prevent drowsy driving will improve the health and safety of the nation.

在睡眠健康和公共安全的交叉点上,疲劳驾驶是一种普遍的驾驶障碍形式。虽然多达21%的机动车事故死亡与嗜睡有关,但嗜睡驾驶在很大程度上是可以预防的,主要是通过允许充足的睡眠机会和获得充足的健康睡眠。国家睡眠基金会呼吁广大社区成员采取有针对性的行动,改善公众睡眠健康和道路安全。打击疲劳驾驶需要司机、教育工作者、政府决策者、医疗保健专业人员、行业、劳工代表、雇主和执法部门采取综合和协调的方法。防止疲劳驾驶的行动将改善国家的健康和安全。
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引用次数: 0
Skin color stratification and sleep duration: Evidence from a nationally representative sample. 肤色分层和睡眠时间:来自全国代表性样本的证据。
IF 3.4 2区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2026-02-01 Epub Date: 2025-12-11 DOI: 10.1016/j.sleh.2025.11.004
Hana Brown, Patricia Louie, Connor Sheehan

Objectives: Sleep shapes population health. While substantial research has illustrated that sleep duration is stratified by racial/ethnic identification in the United States, less is known regarding how these population patterns may also vary by skin color. This is an oversight given that a burgeoning body of research has documented the association between skin color and health. The current study aims to document skin color-based disparities in sleep duration at the population level.

Methods: We analyzed the National Longitudinal Study of Adolescent to Adult Health (Add Health, n = 9114) using multinomial regression to predict differences among adults residing in the US in 2016-2018 in self-reported sleep duration between short sleep (≤6 hours per 24-hour period) and long sleep (≥9 hours per 24-hour period) relative to normal sleep (7-8 hours per 24-hour period) among a nationally representative sample of individuals from the US.

Results: Individuals with dark and to a lesser extent medium skin are at higher odds of short sleep than those with light skin. Individuals with medium and also dark skin are also at higher odds of long sleep than those with light skin. However, evidential support for racial/ethnic moderation of skin tone effects was weak. These results were generally consistent when extensive covariates were included.

Conclusions: This work stresses the importance of race/ethnicity and skin color in shaping population-level sleep patterns.

目的:睡眠影响人口健康。虽然大量研究表明,在美国,睡眠时间是根据种族/民族身份而分层的,但关于这些人口模式如何因肤色而异,我们所知甚少。这是一个疏忽,因为越来越多的研究证明了肤色和健康之间的联系。目前的研究旨在记录人群中基于肤色的睡眠时间差异。方法:我们分析了国家青少年到成人健康纵向研究(Add Health, n = 9114),使用多项回归预测2016-2018年居住在美国的成年人在自我报告的睡眠时间方面的差异,相对于正常睡眠(每24小时7-8小时),短睡眠(每24小时≤6小时)和长睡眠(每24小时≥9小时)。结果:深色皮肤和中度皮肤的人比浅色皮肤的人睡眠不足的几率更高。与浅色皮肤的人相比,中等肤色和深色皮肤的人睡眠时间较长的几率更高。然而,种族/民族调节肤色影响的证据支持很弱。当包括广泛的协变量时,这些结果通常是一致的。结论:这项工作强调了种族/民族和肤色在塑造人口水平睡眠模式中的重要性。
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引用次数: 0
The lexicon of sleep health: A natural language processing bibliometric analysis of the DEI-related terms. 睡眠健康词汇:dei相关术语的自然语言处理文献计量学分析。
IF 3.4 2区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2026-02-01 Epub Date: 2025-11-24 DOI: 10.1016/j.sleh.2025.10.014
Vincent P Martin, Karën Fort, Julien Coelho, François Alla, Jean-Arthur Micoulaud-Franchi

Objective: We assessed the representations of Diversity, Equity and Inclusion-related terms in the sleep health literature as an indicator of the importance of Diversity, Equity and Inclusion-related terms for sleep health research and policies.

Method: We performed a bibliometric analysis and a lexical network of these Diversity, Equity and Inclusion-related terms in previously published literature.

Results: Based on 4047 abstracts, we found 105 out of 163 DEI-related terms (63.5%). A total of 2822 (69.7%) articles had at least one Diversity, Equity and Inclusion-related term. These articles had an average of 4.7 terms per article (sd: 5.7). Interestingly, the ratio of articles containing at least one DEI-related term has risen from 61.1% in 2014 to 73.9% in 2024. On the contrary, the number of Diversity, Equity and Inclusion-related terms in each abstract remains constant over time.

Conclusion: This bibliometric and lexical network study illustrates the difficulty of making research and promoting sleep health policies without Diversity, Equity and Inclusion-related terms.

目的:我们评估了睡眠健康文献中多样性、公平性和包容性相关术语的代表性,作为多样性、公平性和包容性相关术语对睡眠健康研究和政策重要性的指标。方法:我们对先前发表的文献中与多样性、公平性和包容性相关的术语进行了文献计量分析和词汇网络。结果:在4047篇摘要中,我们发现了163个dei相关术语中的105个(63.5%)。总共有2822篇(69.7%)文章至少有一个与多样性、公平和包容性相关的术语。这些文章平均每篇有4.7个术语(sd: 5.7)。有趣的是,包含至少一个dei相关术语的文章比例从2014年的61.1%上升到2024年的73.9%。相反,随着时间的推移,每份摘要中与多样性、公平和包容性相关的术语数量保持不变。结论:这项文献计量学和词汇网络研究表明,在没有多样性、公平和包容性相关术语的情况下,研究和促进睡眠健康政策是困难的。
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引用次数: 0
Positive childhood experiences and insufficient sleep among children and adolescents in the United States: A nationally representative study. 美国儿童和青少年的积极童年经历和睡眠不足:一项全国代表性研究。
IF 3.4 2区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2026-02-01 Epub Date: 2025-10-30 DOI: 10.1016/j.sleh.2025.09.009
Rebecca L Flack, Sophia L Kreider, Cornelius B Groenewald

Objectives: Positive childhood experiences (PCEs), defined as positive social experiences and environments which foster healthy child development, are associated with better mental and physical health outcomes and moderate the negative effects of Adverse Childhood Experiences (ACEs). However, knowledge of the associations between PCEs and childhood sleep deficiency is limited. We conducted cross-sectional analyses of the 2022-2023 National Survey of Children's Health (NSCH) to evaluate associations between PCEs and insufficient sleep (defined as sleeping the recommended number of hours for age each weeknight).

Methods: Parents of children ages 6-17 years old (n = 56,540) reported on their child's exposure to 7 PCEs, including having a resilient and connected family, having an adult mentor, participating in after school activities or volunteering in the community, and living in a supportive and safe neighborhood. Associations between PCEs and insufficient sleep were evaluated using weighted, multivariate logistic regression analyses adjusted for sociodemographic factors.

Results: We found that PCEs had dose-dependent associations with insufficient sleep; children and adolescents exposed to higher numbers of PCEs (5-7 PCEs) had the lowest reported rate of insufficient sleep (29.5%), while those exposed to 2 or fewer PCEs had the highest rate of insufficient sleep (48.0%). Adjusted analysis confirmed that youth experiencing 5-7 PCEs had significantly lower odds of insufficient sleep relative to youth experiencing only 0-2 PCEs (adjusted odds ratio (aOR): 0.57, 95% confidence interval (CI): 0.50-0.68, p<.0001). PCEs moderated associations between ACEs and insufficient sleep.

Conclusions: In conclusion, youth with greater PCEs exposure had lower prevalence rates of insufficient sleep. Furthermore, PCEs were associated with reduced prevalence of insufficient sleep among youth exposed to ACEs.

目标:积极的童年经历(pce)被定义为促进儿童健康发展的积极的社会经历和环境,与更好的心理和身体健康结果有关,并缓和不良童年经历(ace)的负面影响。然而,关于pce与儿童睡眠不足之间关系的知识是有限的。我们对2022-2023年全国儿童健康调查(NSCH)进行了横断面分析,以评估pce与睡眠不足(定义为每个工作日晚上睡眠时间低于推荐的年龄)之间的关系。方法:6-17岁儿童的父母(n = 56540)报告了他们的孩子接触7种pce的情况,包括有一个有弹性和联系的家庭,有一个成年导师,参加课后活动或在社区做志愿者,生活在一个支持性和安全的社区。pce与睡眠不足之间的关系采用加权、多变量逻辑回归分析进行评估,并对社会人口因素进行调整。结果:我们发现pce与睡眠不足存在剂量依赖关系;暴露于较多pce (5-7 pce)的儿童和青少年报告的睡眠不足率最低(29.5%),而暴露于2或更少pce的儿童和青少年睡眠不足率最高(48.0%)。调整后的分析证实,经历5-7次pce的青少年与经历0-2次pce的青少年相比,睡眠不足的几率显著降低(调整后的优势比(aOR): 0.57, 95%可信区间(CI): 0.50-0.68)。结论:总之,pce暴露较多的青少年睡眠不足的患病率较低。此外,pce与暴露于ace的青少年睡眠不足患病率降低有关。
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引用次数: 0
Associations between reservoir bedroom dust allergen levels and sleep symptoms in school-age children. 学龄儿童储层卧室粉尘过敏原水平与睡眠症状之间的关系
IF 3.4 2区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2026-02-01 Epub Date: 2025-11-04 DOI: 10.1016/j.sleh.2025.09.007
Seyni Gueye-Ndiaye, Youmeng Wang, Jing Wang, Cecilia Castro-Diehl, Xinting Yu, Michael Rueschman, Tamar Sofer, Peggy Lai, Judith Owens, Diane R Gold, Gary Adamkiewicz, Nervana Metwali, Peter S Thorne, Wanda Phipatanakul, Susan Redline

Objectives: Exposure to allergens may trigger inflammatory pathways contributing to poor sleep. We investigated the associations between indoor allergen concentrations with multiple sleep dimensions in children.

Methods: Bedroom dust aeroallergens were collected in participants' homes. The outcomes were caregiver-reported sleep-related daytime impairment and sleep disturbance (pediatric PROMIS instruments), sleep-disordered breathing (SDB; apnea-hypopnea index or oxygen desaturation index >5), and actigraphy-based short sleep (<8 hours) duration and poor sleep continuity (sleep fragmentation index > 75th percentile). Logistic regression was used to examine associations between aeroallergens (>50% detectable levels) and sleep outcomes, adjusting for potential confounders (i.e., sociodemographic, environmental, and health-related).

Results: The sample included an urban cohort of 256 children (41% Hispanic, 29% Black; 43% female) aged 6-12 years. Mouse (Mus m 1), cat (Fel d 1), and dog (Can f 1) allergens were detected in 81%, 72%, and 53% of households, respectively. Elevated mouse allergen exposure (>0.55 μg/g-75th percentile) was associated with a 2.6-fold (95% CI: 1.34, 5.03) increased odds for sleep-related daytime impairment (PROMIS T-score > 55) after adjusting for demographic factors. This association persisted after further adjusting for inflammatory-related health factors (asthma, allergic rhinitis, obesity, and environmental tobacco smoke), neighborhood disadvantage, and SDB. There was attenuation of this association with poor sleep consolidation. Associations were not observed for other allergens or other sleep outcomes.

Conclusions: Exposure to elevated mouse dust was associated with increased sleep-related daytime impairment symptoms. The role of household pest exposure as a potentially modifiable target for improving sleep health should be further studied.

目的:暴露于过敏原可能引发炎症通路,导致睡眠质量差。我们调查了儿童室内过敏原浓度与多个睡眠维度之间的关系。方法:在参与者家中收集卧室粉尘空气过敏原。结果是护理人员报告的与睡眠相关的日间损害和睡眠障碍(儿科PROMIS仪器),睡眠呼吸障碍(SDB;呼吸暂停低通气指数或氧去饱和指数bbb5),以及基于活动记录仪的短睡眠(75百分位数)。使用逻辑回归来检查空气过敏原(bbb50 %可检测水平)与睡眠结果之间的关系,并对潜在的混杂因素(即社会人口、环境和健康相关因素)进行调整。结果:样本包括256名6-12岁的城市儿童(41%西班牙裔,29%黑人,43%女性)。小鼠(Mus m1)、猫(Fel d1)和狗(Can f1)过敏原分别在81%、72%和53%的家庭中检出。在调整人口统计学因素后,升高的小鼠过敏原暴露(>0.55 μg/g-75百分位)与2.6倍(95% CI: 1.34, 5.03)增加的与睡眠相关的日间损害(PROMIS t评分> 55)的几率相关。在进一步调整炎症相关健康因素(哮喘、变应性鼻炎、肥胖和环境烟草烟雾)、邻里不利条件和SDB后,这种关联仍然存在。这种与睡眠巩固不良的联系减弱了。没有观察到其他过敏原或其他睡眠结果的关联。结论:暴露于小鼠粉尘升高与睡眠相关的日间损害症状增加有关。应进一步研究家庭有害生物暴露作为改善睡眠健康的潜在可改变目标的作用。
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Sleep Health
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