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A personalized online intervention to enhance back pain-related self-efficacy: A two-arm randomized controlled trial (IDRIS) 个性化在线干预提高背痛相关自我效能感:一项两组随机对照试验(IDRIS)
IF 4.1 2区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-12-01 DOI: 10.1016/j.invent.2025.100892
Paul Hüsing , Mareike Busmann , Bernd Löwe , Petra Engelmann

Objective

Low back pain (LBP) affects daily functioning and strains healthcare systems. Cognitive, behavioral, and emotional factors contribute to its persistence, yet these factors are often neglected in standard care. Personalized digital interventions containing psychoeducational information on relevant biopsychosocial aspects may thus improve outcomes when applied to patients in an early stage. This trial examined whether a brief, personalized animated psychoeducational video—tailored to individual risk profiles based on patient-reported outcome measures (PROMs) and covering biopsychosocial contributors to LBP (depression, catastrophizing, health anxiety, fear of movement, pain endurance behavior, expectations, trauma, emotion regulation)—improves pain-related self-efficacy in adults with acute and subacute low back pain (0–12 weeks).

Methods

In this two-arm randomized controlled trial, participants with back pain (duration <12 weeks) and resulting impairment were randomized to receive either a personalized animated video (intervention) or care as usual (control). Videos comprised modules (≈2–3.5 min per module) selected from eight possible topics based on baseline PROM cut-offs. Outcomes were assessed at baseline, 4 weeks and 12 weeks. Primary analysis used mixed ANOVA to examine changes in pain-related self-efficacy (FESS) over time and between groups; secondary outcomes on biopsychosocial factors were tested with repeated measures ANOVAs and group-adjusted ANCOVAs.

Results

75 participants were included in the analysis. Pain-related self-efficacy improved significantly over time, F(2, 148) = 6.435, p = .002, but without significant group differences, F(2, 148) = 2.146, p = .121. Most secondary outcomes also improved (all p < .001), except pain avoidance-endurance behavior, but analyses did not yield significant differences between intervention and control group (all p > .05. Participants rated the intervention as credible (M = 8.36), with moderate ratings for personal fit and symptom benefit. No adverse events were reported.

Conclusion

Although brief exposure may have limited the impact, the intervention was well-received. Future research should explore integrating personalized psychoeducation into multimodal treatments, emphasizing the importance of individualized approaches for this diverse patient population.

Summary

A brief personalized online intervention improved back-pain self-efficacy, without being superior to an untreated control group. High acceptance seems promising for future multimodal use.
目的腰痛(LBP)影响日常功能并使医疗系统紧张。认知、行为和情感因素导致其持续存在,但这些因素在标准治疗中往往被忽视。个性化的数字干预措施包含相关生物心理社会方面的心理教育信息,因此,在早期阶段应用于患者时,可能会改善结果。该试验研究了一个简短的、个性化的心理教育动画视频,该视频根据患者报告的结果测量(PROMs)为个体风险特征量身定制,涵盖了LBP的生物心理社会因素(抑郁、灾难化、健康焦虑、运动恐惧、疼痛耐受行为、期望、创伤、情绪调节),是否能改善急性和亚急性腰痛(0-12周)成人疼痛相关的自我效能。方法在这项双组随机对照试验中,患有背部疼痛(持续时间为12周)并导致损伤的参与者被随机分为两组,一组接受个性化的动画视频(干预),另一组接受常规护理(对照组)。视频由模块组成(每个模块≈2-3.5分钟),从基于基线PROM截止的八个可能主题中选择。在基线、4周和12周时评估结果。初步分析采用混合方差分析来检验疼痛相关自我效能感(FESS)随时间和组间的变化;采用重复测量方差分析和组校正ancova对生物心理社会因素的次要结局进行检验。结果共纳入75名受试者。疼痛相关自我效能感随时间显著改善,F(2,148) = 6.435, p = 0.002,组间差异无统计学意义,F(2,148) = 2.146, p = 0.121。除了疼痛回避-耐力行为外,大多数次要结局也得到改善(p < 0.001),但分析显示干预组与对照组之间没有显著差异(p < 0.05)。参与者对干预的评价为可信(M = 8.36),对个人健康和症状改善的评价为中等。无不良事件报告。结论虽然短暂接触可能影响有限,但干预效果良好。未来的研究应探索将个性化心理教育整合到多模式治疗中,强调个性化方法对不同患者群体的重要性。简短的个性化在线干预改善了背痛自我效能感,但并不优于未经治疗的对照组。高接受度似乎对未来的多模式使用很有希望。
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引用次数: 0
Adaptive actions as a mechanism of change in transdiagnostic internet-delivered cognitive behavioral therapy: Comparison with homework engagement 自适应行为作为跨诊断网络认知行为治疗的一种改变机制:与作业投入的比较
IF 4.1 2区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-12-01 DOI: 10.1016/j.invent.2025.100894
Heather D. Hadjistavropoulos , Blake F. Dear , Nickolai Titov , Ram P. Sapkota
Adaptive actions have been identified as potential mechanisms of change in transdiagnostic internet-delivered cognitive behavioral therapy (ICBT), but their role relative to homework engagement remains unclear. This study examined whether changes in adaptive actions are maintained at follow-up, their relationship with homework engagement, their individual and joint prediction of diverse treatment outcomes, and their role as mediators and in reciprocal relationships with outcomes. Adults (N = 625) received a transdiagnostic ICBT program in routine care. Outcomes included depression, generalized anxiety, posttraumatic stress, panic, social anxiety, insomnia, functional impairment, and wellbeing. Adaptive actions were assessed with the Things You Do Questionnaire–15 Item (TYDQ–15) and homework engagement with the Homework Reflection Questionnaire (HWRQ). TYDQ–15 scores improved from pre- to post-treatment and were maintained at follow-up. Although correlated, mid-treatment TYDQ–15 scores more consistently predicted outcomes than homework engagement and partially mediated changes across all assessed outcomes. Reciprocal analyses revealed bidirectional relationships between adaptive actions and anxiety and wellbeing, and partially bidirectional associations with depression. Overall, mid-treatment adaptive actions emerged as a stronger and more consistent mechanism of change than homework engagement across diverse outcomes. Findings underscore the importance of research on the benefits of encouraging adaptive actions early in treatment.
适应性行为已被确定为跨诊断互联网认知行为疗法(ICBT)的潜在改变机制,但它们在家庭作业投入中的作用尚不清楚。本研究考察了适应性行为的变化是否在随访中保持,它们与家庭作业参与度的关系,它们对不同治疗结果的个体和联合预测,以及它们作为中介的作用和与结果的相互关系。成人(N = 625)在常规护理中接受了转诊断ICBT程序。结果包括抑郁、广泛性焦虑、创伤后应激、恐慌、社交焦虑、失眠、功能障碍和幸福感。采用“你做的事情”问卷- 15项(TYDQ-15)和“家庭作业反思问卷”(HWRQ)对适应性行为进行评估。TYDQ-15评分从治疗前到治疗后有所改善,并在随访中保持不变。虽然相关,但治疗中期的TYDQ-15分数比家庭作业投入更一致地预测结果,并部分介导所有评估结果的变化。互惠分析揭示了适应性行为与焦虑和幸福感之间的双向关系,以及与抑郁之间的部分双向关联。总体而言,在不同的结果中,治疗中期适应性行动比家庭作业参与表现出更强、更一致的改变机制。研究结果强调了在治疗早期鼓励适应性行动的益处研究的重要性。
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引用次数: 0
Internet-delivered cognitive behavioral therapy versus standard information brochures in advanced cancer caregivers: randomized controlled trial 互联网提供的认知行为疗法与标准信息手册在晚期癌症护理人员:随机对照试验
IF 4.1 2区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-12-01 DOI: 10.1016/j.invent.2025.100891
Yamin Guo

Background

Cancer caregiving is associated with elevated psychological burden, yet scalable interventions remain limited. This randomized controlled trial evaluated a therapist-guided, internet-delivered cognitive behavioral therapy program versus standardized information brochures in informal caregivers of patients with advanced cancer, with caregiver burden specified as the primary outcome and anxiety, depression, and caregiver self-efficacy as secondary outcomes.

Methods

A parallel two-arm randomized controlled trial was conducted among 200 informal caregivers, randomized to either the cognitive-behavioral therapy intervention (n = 100) or the control (n = 100). The intervention comprised an 8-week online cognitive behavioral therapy program supervised by licensed therapists. Primary (caregiver burden) and secondary (anxiety, depression, and caregiver self-efficacy) outcomes were measured using the Zarit Burden Interview–22 caregiver burden scale, the Generalized Anxiety Disorder–7 anxiety scale, the Patient Health Questionnaire–9 depression scale, and the Caregiver Self-Efficacy Scale, administered at baseline, week 4, and week 8. Analyses used linear mixed-effects models with intention-to-treat and sensitivity analyses.

Results

At week 8, caregiver burden decreased by −11.6 ± 6.2 in the internet-delivered cognitive behavioral therapy group versus −2.1 ± 5.9 in the control group (p = 0.027; Cohen's d = 1.35); anxiety decreased by −5.2 versus −0.8 (p = 0.009; d = 1.40); depression decreased by −6.4 versus −1.2 (p = 0.008; d = 1.42); and caregiver self-efficacy increased by +21.9 versus +2.9 (p = 0.021; d = 1.44). A clinical reduction in caregiver burden occurred in 67.0 % of participants in the internet-delivered cognitive-behavioral therapy group, compared with 19.0 % in the control group (odds ratio 8.60; p = 0.005).

Conclusion

In this randomized trial, internet-delivered CBT produced greater improvements than information brochures in caregiver burden (primary outcome) and in anxiety, depression, and self-efficacy over 8 weeks.
癌症护理与心理负担增加有关,但可扩展的干预措施仍然有限。方法对200名非正式照护者进行平行双臂随机对照试验,随机分为认知行为治疗干预组(n = 100)和对照组(n = 100)。干预包括一个为期8周的在线认知行为治疗项目,由有执照的治疗师监督。主要(照顾者负担)和次要(焦虑、抑郁和照顾者自我效能)结果采用Zarit burden访谈- 22照顾者负担量表、广泛性焦虑障碍- 7焦虑量表、患者健康问卷- 9抑郁量表和照顾者自我效能量表进行测量,分别在基线、第4周和第8周进行。分析使用线性混合效应模型和意向治疗和敏感性分析。结果第8周,网络传递认知行为治疗组照顾者负担下降了- 11.6±6.2,对照组为- 2.1±5.9 (p = 0.027; Cohen’s d = 1.35);焦虑降低- 5.2比- 0.8 (p = 0.009; d = 1.40);抑郁症患者为- 6.4 vs - 1.2 (p = 0.008; d = 1.42);照顾者自我效能感提高+21.9比+2.9 (p = 0.021; d = 1.44)。在网络认知行为治疗组中,67.0%的参与者在临床中减轻了照顾者的负担,而在对照组中,这一比例为19.0%(优势比8.60;p = 0.005)。结论:在这项随机试验中,在8周的时间里,互联网提供的CBT在照顾者负担(主要结局)、焦虑、抑郁和自我效能方面比信息手册有更大的改善。
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引用次数: 0
Five years of app evaluation: Insights from a framework in practice – a systematic review on the m-health index and navigation database 五年的应用程序评估:从实践框架的见解——对移动医疗索引和导航数据库的系统回顾
IF 4.1 2区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-11-15 DOI: 10.1016/j.invent.2025.100888
Julian Herpertz , Bridget Dwyer , Ellen Wagner , Jane Mikkelson , Nils Opel , John Torous

Introduction

As the number of health apps continues to rise, concerns about their quality, privacy standards, and adherence to evidence-based healthcare remain. While multiple frameworks exist to assess app quality, a standardized, cross-domain approach is lacking. The M-Health Index and Navigation Database (MIND) comprises a structured framework for app evaluation and a publicly accessible database that applies this framework to rate individual apps. This allows for longitudinal tracking of quality metrics and comparisons across different health app categories.

Methods

We conducted a systematic review to identify studies that utilized either the MIND database or its framework to evaluate health apps. Studies were included if they used MIND in their methodology to evaluate health apps. Data were synthesized descriptively, and two-proportion z-tests were applied for comparisons.

Results

We identified 22 studies, including 16 evaluating commercially available health apps. The most frequently assessed metrics were privacy policies, operating system compatibility, cost, and evidence backing. Only 15 % of mental health apps were supported by feasibility or efficacy studies, nearly one-fourth lacked a privacy policy, and 44 % explicitly disclosed sharing personal health information with third parties. Similar deficiencies were found across non-mental health domains, indicating that concerns regarding app quality and data privacy may not be unique to mental health.

Discussion

Our findings suggest that evidence and privacy concerns are prevalent across almost all health app categories, highlighting the need for stronger regulatory oversight and improved validation standards. MIND serves as a valuable tool for evaluating digital health apps, supporting both app selection and cross-domain quality comparisons.
随着健康应用程序的数量不断增加,人们对它们的质量、隐私标准和对循证医疗保健的依从性的担忧仍然存在。虽然存在多种评估应用质量的框架,但缺乏标准化的跨领域方法。移动健康索引和导航数据库(MIND)包括一个用于应用程序评估的结构化框架和一个可公开访问的数据库,该数据库应用该框架对单个应用程序进行评级。这允许纵向跟踪质量指标,并在不同的健康应用类别之间进行比较。方法我们进行了一项系统综述,以确定利用MIND数据库或其框架评估健康应用程序的研究。如果他们在评估健康应用程序的方法中使用MIND,研究就会被纳入其中。对数据进行描述性综合,采用双比例z检验进行比较。我们确定了22项研究,其中16项评估了市售健康应用程序。最常评估的指标是隐私策略、操作系统兼容性、成本和证据支持。只有15%的心理健康应用程序得到了可行性或有效性研究的支持,近四分之一的应用程序缺乏隐私政策,44%的应用程序明确披露与第三方共享个人健康信息。在非心理健康领域也发现了类似的缺陷,这表明对应用程序质量和数据隐私的担忧可能并非心理健康所独有。我们的研究结果表明,证据和隐私问题在几乎所有健康应用类别中都很普遍,这突出了加强监管和改进验证标准的必要性。MIND是评估数字健康应用程序的宝贵工具,支持应用程序选择和跨域质量比较。
{"title":"Five years of app evaluation: Insights from a framework in practice – a systematic review on the m-health index and navigation database","authors":"Julian Herpertz ,&nbsp;Bridget Dwyer ,&nbsp;Ellen Wagner ,&nbsp;Jane Mikkelson ,&nbsp;Nils Opel ,&nbsp;John Torous","doi":"10.1016/j.invent.2025.100888","DOIUrl":"10.1016/j.invent.2025.100888","url":null,"abstract":"<div><h3>Introduction</h3><div>As the number of health apps continues to rise, concerns about their quality, privacy standards, and adherence to evidence-based healthcare remain. While multiple frameworks exist to assess app quality, a standardized, cross-domain approach is lacking. The M-Health Index and Navigation Database (MIND) comprises a structured framework for app evaluation and a publicly accessible database that applies this framework to rate individual apps. This allows for longitudinal tracking of quality metrics and comparisons across different health app categories.</div></div><div><h3>Methods</h3><div>We conducted a systematic review to identify studies that utilized either the MIND database or its framework to evaluate health apps. Studies were included if they used MIND in their methodology to evaluate health apps. Data were synthesized descriptively, and two-proportion z-tests were applied for comparisons.</div></div><div><h3>Results</h3><div>We identified 22 studies, including 16 evaluating commercially available health apps. The most frequently assessed metrics were privacy policies, operating system compatibility, cost, and evidence backing. Only 15 % of mental health apps were supported by feasibility or efficacy studies, nearly one-fourth lacked a privacy policy, and 44 % explicitly disclosed sharing personal health information with third parties. Similar deficiencies were found across non-mental health domains, indicating that concerns regarding app quality and data privacy may not be unique to mental health.</div></div><div><h3>Discussion</h3><div>Our findings suggest that evidence and privacy concerns are prevalent across almost all health app categories, highlighting the need for stronger regulatory oversight and improved validation standards. MIND serves as a valuable tool for evaluating digital health apps, supporting both app selection and cross-domain quality comparisons.</div></div>","PeriodicalId":48615,"journal":{"name":"Internet Interventions-The Application of Information Technology in Mental and Behavioural Health","volume":"42 ","pages":"Article 100888"},"PeriodicalIF":4.1,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145579060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perspectives of patients, caregivers, and healthcare providers on how the Heart@Home mobile application improves self-management in heart failure care: A qualitative study 患者、护理人员和医疗保健提供者对Heart@Home移动应用程序如何改善心力衰竭护理的自我管理的看法:一项定性研究
IF 4.1 2区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-11-15 DOI: 10.1016/j.invent.2025.100890
Alicha Chumintrachark , Kanokporn Pinyopornpanish , Chanchanok Aramrat , Chutamas Pairoj , Nida Buawangpong , Suphawita Pliannuom , Sarapee Seesopon , Mesaya Khangtanyakit , Nopakoon Nantsupawat , Wichuda Jiraporncharoen , Chaisiri Angkurawaranon , Arintaya Phrommintikul

Objectives

This study aims to investigate the perspectives of patients, caregivers, and healthcare providers on how the Heart@Home application improves self-management following a two-week period of usage and how to improve the application for further utilization.

Methods

This qualitative study used a case study approach. We conducted semi-structured in-depth interviews with patients, caregivers, and healthcare providers and evaluated patients' quality of life before and after using the application. Purposeful sampling was employed, and thematic analysis was performed for qualitative data analysis.

Result

Nine patients, seven caregivers, and two healthcare providers were included in the analysis. The potential benefits for health behavior modification were noted through several mechanisms, including increasing self-awareness of patient's current health status, guide for managing symptoms related to health status changes, and providing emotional assessment, reassurance and a sense of being cared for. In addition, more function in application is needed to increase engagement with application usage. Although the pre-post pilot analysis shows no statistically significant changes in participants' quality of life, as measured by the EQ-5D questionnaire, promising trends were observed in the domains of self-management and daily activity.

Conclusion

The Heart@Home mobile application shows promise in promoting self-management and behavior modification among heart failure patients. Future development should focus on improving technical stability, incorporating personalized feedback, and enabling direct messaging with healthcare providers to enhance the application's effectiveness in managing heart failure.
目的本研究旨在探讨病患、照护者和医疗保健提供者在使用Heart@Home应用程式两周后,如何改善自我管理,以及如何改进应用程式以供进一步使用。方法本定性研究采用个案研究法。我们对患者、护理人员和医疗保健提供者进行了半结构化的深度访谈,并在使用该应用程序前后评估了患者的生活质量。采用有目的的抽样,并进行专题分析进行定性数据分析。结果9名患者、7名护理人员和2名医护人员被纳入分析。健康行为改变的潜在好处是通过几种机制指出的,包括提高患者当前健康状况的自我意识,指导管理与健康状况变化有关的症状,以及提供情绪评估、安慰和被照顾的感觉。此外,应用程序中需要更多的功能来提高应用程序使用的参与度。通过EQ-5D问卷测量,虽然试验前后的分析显示参与者的生活质量没有统计学上的显著变化,但在自我管理和日常活动领域观察到有希望的趋势。结论Heart@Home移动应用程序在促进心力衰竭患者自我管理和行为改变方面具有良好的应用前景。未来的发展应侧重于提高技术稳定性,纳入个性化反馈,并支持与医疗保健提供者的直接消息传递,以提高应用程序在管理心力衰竭方面的有效性。
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引用次数: 0
Rapid relief online: A randomized trial of a single-session simple-swift reconstruction approach group during the COVID-19 surge 在线快速救援:在COVID-19激增期间,单次快速重建方法组的随机试验
IF 4.1 2区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-11-14 DOI: 10.1016/j.invent.2025.100889
Junkai Yang , Yao Chen , Yin Fan , Yunge Bai , Zhang Lin , Huajian Li , Shuangge Sui

Background

Large-scale crises require brief, scalable, on-line mental-health interventions. We examined the effectiveness of a single 90–120 min videoconference group based on the Simple-Swift Reconstruction Approach (SSRA).

Methods

In a parallel-group randomized trial, 277 Chinese adults were assigned to SSRA (n = 143) or a waiting-list control (n = 134). Baseline and 2-week outcomes were the Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and General Self-Efficacy Scale (GSES). The SSRA group also completed Subjective Units of Disturbance (SUD) ratings immediately before and after the session. Complete-case analyses used paired and independent t-tests with Cohen's d (two-tailed α = 0.05).

Results

One hundred twenty-one SSRA participants (19 % male; M = 34.9 years, SD = 11.3) attended the SSRA session and showed a large within-session SUD reduction (baseline M = 5.81, SD = 1.62; post M = 3.20, SD = 1.57; t(120) = 19.26, p < .001, d = 1.75). Two-week follow-up data were available for 71 SSRA and 19 control participants (retention = 32.5 %). Within the SSRA group, depressive symptoms (Δ = −2.14, d = 0.63), anxiety (Δ = −1.89, d = 0.66), and self-efficacy (Δ = +2.28, d = 0.41) improved descriptively. However, only the between-group difference for depression (PHQ-9) reached significance (t(24.7) = −2.60, p = .015, d = 0.76); between-group GAD-7 and GSES were nonsignificant. Age and sex did not moderate outcomes.

Conclusions

A one-off, on-line SSRA group produced a large within-session reduction in subjective distress and a significant between-group improvement in depressive symptoms over two weeks, supporting SSRA as a rapid, low-intensity option during public-health emergencies. Replication with larger samples and longer follow-up is recommended.
大规模危机需要简短、可扩展的在线心理健康干预。我们检查了基于简单-快速重建方法(SSRA)的单次90-120分钟视频会议组的有效性。方法在一项平行组随机试验中,277名中国成年人被分配到SSRA组(n = 143)或等待名单对照组(n = 134)。基线和2周的结果是患者健康问卷-9 (PHQ-9)、广泛性焦虑障碍-7 (GAD-7)和一般自我效能量表(GSES)。SSRA组还在治疗前后立即完成了主观障碍单元(SUD)评分。全病例分析采用Cohen’s d的配对和独立t检验(双尾α = 0.05)。结果121名SSRA参与者(19%为男性,M = 34.9岁,SD = 11.3)参加了SSRA会议,会议期间SUD大幅减少(基线M = 5.81, SD = 1.62;后M = 3.20, SD = 1.57; t(120) = 19.26, p < 0.001, d = 1.75)。71名SSRA参与者和19名对照参与者可获得两周随访数据(保留率为32.5%)。在SSRA组中,抑郁症状(Δ = - 2.14, d = 0.63)、焦虑(Δ = - 1.89, d = 0.66)和自我效能感(Δ = +2.28, d = 0.41)均有显著改善。但只有抑郁(PHQ-9)组间差异有显著性意义(t(24.7) =−2.60,p = 0.015, d = 0.76);GAD-7和GSES组间差异无统计学意义。年龄和性别对结果没有影响。结论:一次性在线SSRA组在两周内显著减少了主观痛苦,并在组间显著改善了抑郁症状,支持SSRA作为突发公共卫生事件中快速、低强度的选择。建议使用更大的样本和更长的随访时间进行复制。
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引用次数: 0
Cost-effectiveness and cost-utility of a therapist-guided online intervention provided soon after trauma: Results from a randomized controlled trial 创伤后不久治疗师指导的在线干预的成本效益和成本效用:来自一项随机对照试验的结果
IF 4.1 2区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-11-06 DOI: 10.1016/j.invent.2025.100886
Maria Bragesjö , Filip K. Arnberg , Erik Andersson
This study evaluated the cost-effectiveness and cost-utility of a therapist-guided, internet-delivered early intervention for trauma. Exposure to traumatic events is common and can lead to substantial psychological distress, functional impairment, and societal costs. Early psychological interventions have the potential to mitigate these effects. We developed Condensed Internet-delivered Prolonged Exposure (CIPE), a digital intervention delivered within two months of trauma exposure. In a randomized controlled trial (N = 102), CIPE was more effective than a waiting-list control in reducing post-traumatic stress symptoms at post-intervention (3 weeks) and at a prespecified 7-week follow-up while the waiting-list control remained intact (prior to crossover). In this study, we evaluated CIPE from a societal cost perspective, aggregating direct medical costs (healthcare contacts, medication) and indirect costs (sick leave, reduced productivity, domestic loss) with equal weight in total cost calculations using a self-report questionnaire. Cost-effectiveness was assessed using responder status (≥10-point symptom reduction) and subthreshold symptom status on the PTSD Checklist for DSM-5. Cost-utility was assessed using quality-adjusted life years (QALYs) from the EQ-5D. Incremental cost-effectiveness ratios (ICERs) were estimated using bootstrapped regression analyses and visualized in cost-effectiveness planes and acceptability curves. CIPE showed a 95 % probability of being cost-effective at a willingness-to-pay threshold of €939–1181 per additional responder or subthreshold case. The corresponding cost per QALY gained was €2929–3636. Effects were sustained at 12-month follow-up. These findings suggest that therapist-guided digital exposure therapy delivered soon after trauma can reduce symptoms at a relatively low cost to society. Future research should examine CIPE's long-term economic impact and potential for broader implementation.
本研究评估了一种治疗师指导的、互联网提供的创伤早期干预的成本效益和成本效用。暴露于创伤性事件是常见的,可导致严重的心理困扰、功能损害和社会成本。早期的心理干预有可能减轻这些影响。我们开发了浓缩互联网传递的延长暴露(CIPE),这是一种在两个月内提供创伤暴露的数字干预。在一项随机对照试验(N = 102)中,在干预后(3周)和预先指定的7周随访中,CIPE在减少创伤后应激症状方面比等候名单对照组更有效,而等候名单对照组保持完整(交叉之前)。在本研究中,我们从社会成本的角度对CIPE进行了评估,汇总了直接医疗成本(医疗联系、药物)和间接成本(病假、生产力下降、家庭损失),在总成本计算中占同等权重。使用DSM-5 PTSD检查表中的应答者状态(症状减轻≥10点)和阈下症状状态评估成本-效果。使用EQ-5D的质量调整寿命年(QALYs)评估成本效用。增量成本-效果比(ICERs)使用自适应回归分析估计,并在成本-效果平面和可接受度曲线中可视化。CIPE显示,在愿意支付阈值为939-1181欧元的情况下,每个额外的应答者或低于阈值的病例具有成本效益的可能性为95%。每个获得的QALY相应成本为2929-3636欧元。在12个月的随访中,效果持续。这些发现表明,创伤后不久由治疗师指导的数字暴露疗法可以以相对较低的社会成本减轻症状。未来的研究应该检查CIPE的长期经济影响和更广泛实施的潜力。
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引用次数: 0
Examining an entirely self-guided transdiagnostic internet-delivered intervention ‘in the wild’: A randomised controlled trial for anxiety and depression with minimal inclusion criteria 检查完全自我引导的互联网传递的跨诊断干预“在野外”:一个最小纳入标准的焦虑和抑郁的随机对照试验
IF 4.1 2区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-11-02 DOI: 10.1016/j.invent.2025.100887
Blake F. Dear , Alana Fisher , Madelyne Bisby , Amelia Scott , Nickolai Titov
Entirely self-guided transdiagnostic internet-delivered psychological interventions have considerable potential for increasing access to care for adults with anxiety and depression. The current study sought to examine such an intervention under real-world conditions using minimal inclusion and exclusion criteria. Three-hundred and ninety participants were randomised to either an immediate treatment group or a waitlist control group. The intervention consisted of 5 core modules delivered over 8 weeks, according to a structured timetable and with automated emails. Fifty-three percent of participants completed ≥4 of the core modules, and 75 % reported being satisfied with the intervention. At post-treatment, significant improvements were observed in the treatment group compared with control in both anxiety (treatment = 19 % [95 % CI: 12, 26]; control = 8 % [95 % CI: 2, 15]) and depression (treatment = 21 % [95 % CI: 13, 28]; control = 5 % [95 % CI: −1, 12]). These improvements were reflected in significantly greater proportions of participants meeting criteria for clinically meaningful change (≥50 % reduction) in the treatment group for both anxiety (treatment = 25 % [95 % CI: 19, 31]; control = 9 % [95 % CI: 5, 16]) and depression (treatment = 27 % [95 % CI: 20, 36]; control = 8 % [95 % CI: 5, 14]), with numbers needed to treat (NNTs) of 6.6 and 5.3, respectively. The findings of the current study support the potential of entirely self-guided transdiagnostic internet-delivered interventions, particularly for people for whom speaking with a clinician represents a barrier to care, or contexts where the resources for clinician-guided intervention are not available.
完全自我引导的跨诊断互联网心理干预在增加焦虑和抑郁成年人获得护理方面具有相当大的潜力。目前的研究试图在现实世界条件下使用最小的纳入和排除标准来检验这种干预。390名参与者被随机分为立即治疗组和候补对照组。干预包括5个核心模块,在8周内完成,根据结构化的时间表和自动电子邮件。53%的参与者完成了≥4个核心模块,75%的参与者报告对干预措施感到满意。治疗后,治疗组在焦虑(治疗= 19% [95% CI: 12, 26];对照组= 8% [95% CI: 2, 15])和抑郁(治疗= 21% [95% CI: 13, 28];对照组= 5% [95% CI: - 1, 12])方面均较对照组有显著改善。这些改善反映在治疗组达到临床意义改变(≥50%减少)标准的参与者比例上,治疗组治疗焦虑症(治疗= 25% [95% CI: 19, 31];对照组= 9% [95% CI: 5, 16])和抑郁症(治疗= 27% [95% CI: 20, 36];对照组= 8% [95% CI: 5, 14]),需要治疗的人数(NNTs)分别为6.6和5.3。目前的研究结果支持了完全自我引导的互联网跨诊断干预的潜力,特别是对于那些与临床医生交谈代表着护理障碍的人,或者在没有临床医生指导的干预资源的情况下。
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引用次数: 0
Unfinished business in virtual reality: Development and preliminary evaluation of an empty chair intervention grounded in emotion-focused therapy 虚拟现实中未完成的事业:以情感为中心的治疗为基础的空椅子干预的发展和初步评估
IF 4.1 2区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-10-22 DOI: 10.1016/j.invent.2025.100885
Júlia Halamová , Lenka Ottingerová , Zuzana Berger Haladova , Leslie S. Greenberg
The immersive capabilities of virtual reality (VR) make it a promising medium for psychotherapeutic interventions. This randomized controlled trial aimed to develop and evaluate a VR-based adaptation of Emotion-Focused Therapy for Unfinished Business (EFT-UFB). Specifically, we examined its effects on unresolved emotional experiences, self-compassion, self-protection, self-criticism, and perceived stress. Participants (N = 52) were randomly assigned to either the intervention group (n = 26) or a waitlist control group (n = 26), with assessments conducted at pre-test, post-test, and follow-up. The primary between-group analyses revealed no statistically significant differences between the intervention and control groups at post-test (unfinished business: t(50) = −2.00, p = .051, Cohen's d = −0.38, 95 % CI [−0.77, 0.01]) or at follow-up (t(50) = 0.60, p = .551, d = 0.08, 95 % CI [−0.31, 0.47]). Within the intervention group, unfinished business demonstrated a large pre–post reduction that was sustained at follow-up, whereas other effects were small or transient. Effect size estimates suggested small advantages for the intervention arm across several outcomes, including unfinished business (d = −1.01 vs. 0.44 in controls), self-criticism (Inadequate Self d = −0.47), and perceived stress (helplessness d = −0.33; self-efficacy d = 0.37). Other domains, including self-compassion and self-protection, showed negligible or inconsistent differences. While the VR-based EFT-UFB did not outperform the waitlist condition, these pilot findings provide preliminary evidence of feasibility and potential benefits for unfinished business. Importantly, the intervention was effectively delivered by a non-psychotherapist (a trained psychologist), underscoring its potential scalability within digital mental health applications.
虚拟现实(VR)的沉浸式能力使其成为心理治疗干预的有前途的媒介。这项随机对照试验旨在开发和评估一种基于vr的未完成事业情绪聚焦疗法(EFT-UFB)。具体来说,我们研究了它对未解决的情绪体验、自我同情、自我保护、自我批评和感知压力的影响。参与者(N = 52)被随机分配到干预组(N = 26)或候补对照组(N = 26),并在测试前、测试后和随访中进行评估。初步组间分析显示,干预组与对照组在测试后(未完成的事情:t(50) = - 2.00, p = 0.051, Cohen’s d = - 0.38, 95% CI[- 0.77, 0.01])或随访时(t(50) = 0.60, p = .551, d = 0.08, 95% CI[- 0.31, 0.47])无统计学差异。在干预组中,未完成的事情显示出在随访中持续的大量前后减少,而其他影响很小或短暂。效应量估计表明,干预组在几个结果上有较小的优势,包括未完成的事业(d = - 1.01,对照组为0.44)、自我批评(d = - 0.47)和感知压力(无助d = - 0.33;自我效能d = 0.37)。其他领域,包括自我同情和自我保护,表现出微不足道或不一致的差异。虽然基于vr的EFT-UFB并没有超过等待名单条件,但这些试点结果为未完成的业务提供了可行性和潜在效益的初步证据。重要的是,干预是由非心理治疗师(训练有素的心理学家)有效地提供的,强调了其在数字心理健康应用中的潜在可扩展性。
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引用次数: 0
Adolescents' and youths' perceived barriers and facilitators to engaging with digital mental health interventions for depression and anxiety: A scoping review 青少年和青年参与抑郁症和焦虑症数字心理健康干预的感知障碍和促进因素:范围审查
IF 4.1 2区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-10-21 DOI: 10.1016/j.invent.2025.100884
Vajisha Udayangi Wanniarachchi , Chris Greenhalgh , Jim Warren
Digital mental health interventions (DMHIs) can be effective for adolescents and young people experiencing depression and anxiety. However, maintaining engagement remains a persistent challenge. While internal factors such as interface design, interactivity and personalisation have been widely examined, less is known about how young people themselves perceive barriers and facilitators to engaging with these tools. This scoping review explores adolescents' and young people's perceived experiences of engagement with DMHIs. A systematic search in PubMed, Scopus and PsycInfo identified 37 studies that met the inclusion criteria. Analysis revealed a broad range of perceived facilitators, including accessibility, perceived usefulness, opportunities for social connection and supportive human involvement. Commonly reported barriers included stigma, privacy concerns, low motivation, lack of personalisation, technical difficulties and limited trust in the interventions. Notably, most studies reported these perceptions qualitatively, with limited systematic assessment of their impact on engagement. This highlights a gap in the evidence base and underscores the need for future research to quantify how perceived barriers and facilitators shape engagement and adherence. Addressing barriers while building on facilitators may enhance sustained engagement and improve the real-world effectiveness of DMHIs for adolescent mental health.
数字心理健康干预措施(DMHIs)对经历抑郁和焦虑的青少年和年轻人可能有效。然而,保持用户粘性仍然是一个持续的挑战。虽然界面设计、交互性和个性化等内部因素已经得到了广泛的研究,但对于年轻人自己如何看待使用这些工具的障碍和促进因素,人们知之甚少。本综述探讨了青少年和年轻人参与DMHIs的感知体验。在PubMed、Scopus和PsycInfo中进行了系统搜索,确定了37项符合纳入标准的研究。分析揭示了广泛的感知促进因素,包括可及性、感知有用性、社会联系机会和支持性的人类参与。通常报告的障碍包括耻辱、隐私问题、动机低、缺乏个性化、技术困难和对干预措施的信任有限。值得注意的是,大多数研究定性地报告了这些看法,对其对敬业度的影响进行了有限的系统评估。这突出了证据基础上的差距,并强调了未来研究的必要性,以量化感知到的障碍和促进因素如何影响参与和坚持。在建立促进者的基础上解决障碍,可以加强持续参与,提高DMHIs在青少年心理健康方面的实际有效性。
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引用次数: 0
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Internet Interventions-The Application of Information Technology in Mental and Behavioural Health
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