Pub Date : 2023-03-28DOI: 10.1007/s42242-022-00227-x
F. Rahimi, Nima Ahmadkhani, Aida Goodarzi, F. Noori, Sajad Hassanzadeh, S. Saghati, M. Khanmohammadi, A. Goodarzi
{"title":"Gelatin-based hydrogel functionalized with taurine moieties for in vivo skin tissue regeneration","authors":"F. Rahimi, Nima Ahmadkhani, Aida Goodarzi, F. Noori, Sajad Hassanzadeh, S. Saghati, M. Khanmohammadi, A. Goodarzi","doi":"10.1007/s42242-022-00227-x","DOIUrl":"https://doi.org/10.1007/s42242-022-00227-x","url":null,"abstract":"","PeriodicalId":48627,"journal":{"name":"Bio-Design and Manufacturing","volume":"64 1","pages":"284-297"},"PeriodicalIF":7.9,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53338464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-24DOI: 10.1007/s42242-023-00231-9
Haowei Xu, Yang Liao, M. Svetlana, Deguang Yang, Huaibin Wan, Zonghuai Liu
{"title":"Enhancement of intranasal mucosal immunization of mucosal vaccines by ultrasonic treatment","authors":"Haowei Xu, Yang Liao, M. Svetlana, Deguang Yang, Huaibin Wan, Zonghuai Liu","doi":"10.1007/s42242-023-00231-9","DOIUrl":"https://doi.org/10.1007/s42242-023-00231-9","url":null,"abstract":"","PeriodicalId":48627,"journal":{"name":"Bio-Design and Manufacturing","volume":"6 1","pages":"405 - 422"},"PeriodicalIF":7.9,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43945699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-22DOI: 10.1007/s42242-022-00229-9
Qiong-Ming Liu, L. S. Mille, Cesar Villalobos, Ingrid Anaya, Matthias Vostatek, Sili Yi, Wanlu Li, Junlong Liao, Huanghui Wu, Yongteng Song, Lize Xiong, Y. S. Zhang
{"title":"3D-bioprinted cholangiocarcinoma-on-a-chip model for evaluating drug responses","authors":"Qiong-Ming Liu, L. S. Mille, Cesar Villalobos, Ingrid Anaya, Matthias Vostatek, Sili Yi, Wanlu Li, Junlong Liao, Huanghui Wu, Yongteng Song, Lize Xiong, Y. S. Zhang","doi":"10.1007/s42242-022-00229-9","DOIUrl":"https://doi.org/10.1007/s42242-022-00229-9","url":null,"abstract":"","PeriodicalId":48627,"journal":{"name":"Bio-Design and Manufacturing","volume":"6 1","pages":"373 - 389"},"PeriodicalIF":7.9,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44014907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.1007/s42242-023-00239-1
Xiaodan Huo, Bin Zhang, Qianglong Han, Yong Huang, Jun Yin
{"title":"Numerical simulation and printability analysis of fused deposition modeling with dual-temperature control","authors":"Xiaodan Huo, Bin Zhang, Qianglong Han, Yong Huang, Jun Yin","doi":"10.1007/s42242-023-00239-1","DOIUrl":"https://doi.org/10.1007/s42242-023-00239-1","url":null,"abstract":"","PeriodicalId":48627,"journal":{"name":"Bio-Design and Manufacturing","volume":"6 1","pages":"174-188"},"PeriodicalIF":7.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43797181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.1007/s42242-023-00233-7
Liang Ma, Huayong Yang
{"title":"Bio-manufacturing innovation lights up the future","authors":"Liang Ma, Huayong Yang","doi":"10.1007/s42242-023-00233-7","DOIUrl":"https://doi.org/10.1007/s42242-023-00233-7","url":null,"abstract":"","PeriodicalId":48627,"journal":{"name":"Bio-Design and Manufacturing","volume":"6 1","pages":"204-215"},"PeriodicalIF":7.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45085558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-28DOI: 10.1007/s42242-023-00234-6
Jun Yin, J. Qian, Yong Huang
{"title":"Physics problems in bio or bioinspired additive manufacturing","authors":"Jun Yin, J. Qian, Yong Huang","doi":"10.1007/s42242-023-00234-6","DOIUrl":"https://doi.org/10.1007/s42242-023-00234-6","url":null,"abstract":"","PeriodicalId":48627,"journal":{"name":"Bio-Design and Manufacturing","volume":"6 1","pages":"99 - 102"},"PeriodicalIF":7.9,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43352669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-05DOI: 10.1007/s42242-022-00218-y
A. E. Pazarçeviren, Z. Evis, Tayfun Dikmen, K. Altunbaş, M. Yaprakçi, D. Keskin, A. Tezcaner
{"title":"Alginate/gelatin/boron-doped hydroxyapatite-coated Ti implants: in vitro and in vivo evaluation of osseointegration","authors":"A. E. Pazarçeviren, Z. Evis, Tayfun Dikmen, K. Altunbaş, M. Yaprakçi, D. Keskin, A. Tezcaner","doi":"10.1007/s42242-022-00218-y","DOIUrl":"https://doi.org/10.1007/s42242-022-00218-y","url":null,"abstract":"","PeriodicalId":48627,"journal":{"name":"Bio-Design and Manufacturing","volume":"1 1","pages":"1-26"},"PeriodicalIF":7.9,"publicationDate":"2023-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42611012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1007/s42242-022-00205-3
Saeed Fathi, Iek Man Lei, Yang Cao, Yan Yan Shery Huang
Extrusion-based cell deposition has become a prominent technique for expanding bioprinting applications. However, the associated print resolution in the order of nanolitre or above has been a limiting factor. The demand for improving print resolution towards the scale of a single cell has driven the development of precision nozzle extrusion, although the benefits gained remain ambiguous. Here, aided by in situ imaging, we investigated the dynamics of cell organisation through an extrusion-based microcapillary tip with picolitre precision through in-air or immersion deposition. The microcapillary extrusion setup, termed 'Picodis', was demonstrated by generating droplets of colouring inks immersed in an immiscible medium. Next, using 3T3 fibroblast cells as an experimental model, we demonstrated the deposition of cell suspension, and pre-aggregated cell pellets. Then, the dynamic organisation of cells within the microcapillary tip was described, along with cell ejection and deposition upon exiting the tip opening. The vision-assisted approach revealed that when dispersed in a culture medium, the movements of cells were distinctive based on the flow profiles and were purely driven by laminar fluid flow within a narrow tip. The primary process limitations were cell sedimentation, aggregation and compaction, along with trapped air bubbles. The use of picolitre-level resolution microcapillary extrusion, although it provides some level of control for a small number of cells, does not necessarily offer a reliable method when a specified number of cells are required. Our study provides insights into the process limitations of high-resolution cell ink extrusion, which may be useful for optimising biofabrication processes of cell-laden constructs for biomedical research.
Supplementary information: The online version contains supplementary material available at 10.1007/s42242-022-00205-3.
{"title":"Microcapillary cell extrusion deposition with picolitre dispensing resolution.","authors":"Saeed Fathi, Iek Man Lei, Yang Cao, Yan Yan Shery Huang","doi":"10.1007/s42242-022-00205-3","DOIUrl":"https://doi.org/10.1007/s42242-022-00205-3","url":null,"abstract":"<p><p>Extrusion-based cell deposition has become a prominent technique for expanding bioprinting applications. However, the associated print resolution in the order of nanolitre or above has been a limiting factor. The demand for improving print resolution towards the scale of a single cell has driven the development of precision nozzle extrusion, although the benefits gained remain ambiguous. Here, aided by in situ imaging, we investigated the dynamics of cell organisation through an extrusion-based microcapillary tip with picolitre precision through in-air or immersion deposition. The microcapillary extrusion setup, termed 'Picodis', was demonstrated by generating droplets of colouring inks immersed in an immiscible medium. Next, using 3T3 fibroblast cells as an experimental model, we demonstrated the deposition of cell suspension, and pre-aggregated cell pellets. Then, the dynamic organisation of cells within the microcapillary tip was described, along with cell ejection and deposition upon exiting the tip opening. The vision-assisted approach revealed that when dispersed in a culture medium, the movements of cells were distinctive based on the flow profiles and were purely driven by laminar fluid flow within a narrow tip. The primary process limitations were cell sedimentation, aggregation and compaction, along with trapped air bubbles. The use of picolitre-level resolution microcapillary extrusion, although it provides some level of control for a small number of cells, does not necessarily offer a reliable method when a specified number of cells are required. Our study provides insights into the process limitations of high-resolution cell ink extrusion, which may be useful for optimising biofabrication processes of cell-laden constructs for biomedical research.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s42242-022-00205-3.</p>","PeriodicalId":48627,"journal":{"name":"Bio-Design and Manufacturing","volume":"6 1","pages":"1-11"},"PeriodicalIF":7.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9085603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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