首页 > 最新文献

Primary Health Care Research and Development最新文献

英文 中文
Interventions to support early childhood development in times of COVID-19: A Systematic Review 2019冠状病毒病期间支持儿童早期发展的干预措施:系统回顾
IF 1.6 4区 医学 Q2 Nursing Pub Date : 2021-01-01 DOI: 10.15761/hpc.1000214
K. Rahim, S. Bhamani, Z. Lassi
Background: COVID-19 which has come as an emerging disease was declared a pandemic by the World Health Organization in March 2020. In an attempt to limit the spread of this virus, strict measures were taken amongst which closure of schools and child care facilities were also implemented. This impacted the holistic well-being of the children. Objective: This systematic review aimed at identifying early childhood development (ECD) interventions targeted to children 0-8 years of age conducted and reported during the COVID-19 pandemic in low and middle-income countries, and also to identify the barriers and facilitators to taking up ECD activities during the COVID-19 pandemic. Methodology: This systematic review considered all published and pre-print studies published between 31 Dec 2019 and 31 Dec 2020 and followed PRISMA guidelines for the conduct of the systematic review. Databases such as MEDLINE, Embase, ERIC, CINAHL, the Cochrane Central Register of Controlled Trials (CENTRAL), Google Scholar, and the WHO COVID-19 database were searched. Result: Zero studies were included at the end of the full-text screening. Few papers were fitting well with the scope of the paper; however, those papers were not fitting the study design. The majority of those papers were position papers and opinion papers. Conclusion: This empty review highlighted a major research gap in the literature. There were no studies conducted to address the interventions taken place in the pandemic to support ECD. There is a dire need to address the issue by conducting more quantitative and qualitative studies. *Correspondence to: Zohra S Lassi, Robinson Research Institute, the University of Adelaide, Australia, E-mail: Zohra.lassi@adelaide.edu.au
背景:2019冠状病毒病是一种新兴疾病,于2020年3月被世界卫生组织宣布为大流行。为了限制这种病毒的传播,采取了严格的措施,其中包括关闭学校和儿童保育设施。这影响了孩子们的整体健康。目的:本系统综述旨在确定低收入和中等收入国家在2019冠状病毒病大流行期间实施和报告的针对0-8岁儿童的幼儿发展(ECD)干预措施,并确定在2019冠状病毒病大流行期间开展幼儿发展活动的障碍和促进因素。方法:本系统评价考虑了2019年12月31日至2020年12月31日期间发表的所有已发表和预印本研究,并遵循PRISMA指南进行系统评价。检索了MEDLINE、Embase、ERIC、CINAHL、Cochrane中央对照试验注册库(Central)、谷歌Scholar和WHO COVID-19数据库等数据库。结果:在全文筛选结束时,零项研究被纳入。很少有论文与论文的范围很吻合;然而,这些论文并不符合研究设计。这些文件大多数是立场文件和意见文件。结论:这篇空白综述突出了文献中一个主要的研究空白。没有进行任何研究,讨论在大流行病期间为支持幼儿发展而采取的干预措施。迫切需要通过进行更多的定量和定性研究来解决这一问题。*通讯:Zohra S Lassi,澳大利亚阿德莱德大学罗宾逊研究所,E-mail: Zohra.lassi@adelaide.edu.au
{"title":"Interventions to support early childhood development in times of COVID-19: A Systematic Review","authors":"K. Rahim, S. Bhamani, Z. Lassi","doi":"10.15761/hpc.1000214","DOIUrl":"https://doi.org/10.15761/hpc.1000214","url":null,"abstract":"Background: COVID-19 which has come as an emerging disease was declared a pandemic by the World Health Organization in March 2020. In an attempt to limit the spread of this virus, strict measures were taken amongst which closure of schools and child care facilities were also implemented. This impacted the holistic well-being of the children. Objective: This systematic review aimed at identifying early childhood development (ECD) interventions targeted to children 0-8 years of age conducted and reported during the COVID-19 pandemic in low and middle-income countries, and also to identify the barriers and facilitators to taking up ECD activities during the COVID-19 pandemic. Methodology: This systematic review considered all published and pre-print studies published between 31 Dec 2019 and 31 Dec 2020 and followed PRISMA guidelines for the conduct of the systematic review. Databases such as MEDLINE, Embase, ERIC, CINAHL, the Cochrane Central Register of Controlled Trials (CENTRAL), Google Scholar, and the WHO COVID-19 database were searched. Result: Zero studies were included at the end of the full-text screening. Few papers were fitting well with the scope of the paper; however, those papers were not fitting the study design. The majority of those papers were position papers and opinion papers. Conclusion: This empty review highlighted a major research gap in the literature. There were no studies conducted to address the interventions taken place in the pandemic to support ECD. There is a dire need to address the issue by conducting more quantitative and qualitative studies. *Correspondence to: Zohra S Lassi, Robinson Research Institute, the University of Adelaide, Australia, E-mail: Zohra.lassi@adelaide.edu.au","PeriodicalId":48703,"journal":{"name":"Primary Health Care Research and Development","volume":"14 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74743752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathology Study for Human Suicide 人类自杀的病理学研究
IF 1.6 4区 医学 Q2 Nursing Pub Date : 2021-01-01 DOI: 10.15761/hpc.1000209
D. Lu, Hong-ying Wu, Bin Xu
Wide spectra of risk factors can generate human suicide episodes and victim. To achieve an ultimate goal of suicide management, pathological origin and progress of human suicide should be unveiled. Current different suicide origin and pathological progress between susceptible population, mental disordered patients and normal people should be understood. Therapeutic knowledge may be built by translating different types of pathology knowledge into clinically technical modernization (diagnostics and instruments).
广泛的危险因素可以产生人类自杀事件和受害者。为了达到自杀管理的最终目的,必须揭示人类自杀的病理起源和发展过程。目前应了解易感人群、精神障碍患者和正常人自杀原因及病理进展的不同。通过将不同类型的病理知识转化为临床技术现代化(诊断和仪器),可以建立治疗知识。
{"title":"Pathology Study for Human Suicide","authors":"D. Lu, Hong-ying Wu, Bin Xu","doi":"10.15761/hpc.1000209","DOIUrl":"https://doi.org/10.15761/hpc.1000209","url":null,"abstract":"Wide spectra of risk factors can generate human suicide episodes and victim. To achieve an ultimate goal of suicide management, pathological origin and progress of human suicide should be unveiled. Current different suicide origin and pathological progress between susceptible population, mental disordered patients and normal people should be understood. Therapeutic knowledge may be built by translating different types of pathology knowledge into clinically technical modernization (diagnostics and instruments).","PeriodicalId":48703,"journal":{"name":"Primary Health Care Research and Development","volume":"56 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77454040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaccination and Risk identification & Risk management: a true controversy? 疫苗接种与风险识别和风险管理:真正的争议?
IF 1.6 4区 医学 Q2 Nursing Pub Date : 2021-01-01 DOI: 10.15761/HPC.1000207
J. Noordhuizen
In this short paper two aspects of veterinary preventive medicine are addressed: applying vaccines and implementing risk identification and risk management plans. Both should go hand-in-hand on animal production farms because they are mutually beneficial. Moreover, the potential risk of economic losses is drastically lowered. In this short paper both domains are briefly highlighted. A dairy farm is used for illustration purposes. *Correspondence to: Jos Noordhuizen, DVM, PhD, Former Diplomate at EC BHM and VPM, School of Agriculture and Veterinary Science, Charles Sturt University, Boorooma Street, North Wagga, NSW, Australia, E-mail: josnoord@ gmail.com Received: January 06, 2021; Accepted: January 22, 2021; Published: January 25, 202
在这篇短文中,讨论了兽医预防医学的两个方面:应用疫苗和实施风险识别和风险管理计划。在动物生产农场,两者应该携手并进,因为它们是互利的。此外,潜在的经济损失风险也大大降低。在这篇短文中,简要地强调了这两个领域。这里用一个奶牛场来说明。*通讯对象:Jos Noordhuizen, DVM, PhD, EC BHM和VPM前外交人员,Charles Sturt大学农业与兽医科学学院,Boorooma Street, North Wagga, NSW, Australia, E-mail: josnoord@gmail.com录用日期:2021年1月22日;出版日期:2002年1月25日
{"title":"Vaccination and Risk identification & Risk management: a true controversy?","authors":"J. Noordhuizen","doi":"10.15761/HPC.1000207","DOIUrl":"https://doi.org/10.15761/HPC.1000207","url":null,"abstract":"In this short paper two aspects of veterinary preventive medicine are addressed: applying vaccines and implementing risk identification and risk management plans. Both should go hand-in-hand on animal production farms because they are mutually beneficial. Moreover, the potential risk of economic losses is drastically lowered. In this short paper both domains are briefly highlighted. A dairy farm is used for illustration purposes. *Correspondence to: Jos Noordhuizen, DVM, PhD, Former Diplomate at EC BHM and VPM, School of Agriculture and Veterinary Science, Charles Sturt University, Boorooma Street, North Wagga, NSW, Australia, E-mail: josnoord@ gmail.com Received: January 06, 2021; Accepted: January 22, 2021; Published: January 25, 202","PeriodicalId":48703,"journal":{"name":"Primary Health Care Research and Development","volume":"2012 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82629063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autologous Arteriovenous Fistula Creation for Haemodialysis in Small Children 儿童血液透析自体动静脉造瘘术
IF 1.6 4区 医学 Q2 Nursing Pub Date : 2021-01-01 DOI: 10.15761/HPC.1000203
Dragan Piljic, N. Sehic, Dilista Piljić, Fahrudin Sabanovic, M. Petricevic, G. Samoukovic
A 11-years old female with growth problem and chronic renal failure was admitted for arteriovenous fistula (AVF) formation for long-term haemodialysis in the pediatric ward. During her hospital stay, continue to have a cuffed central venous catheter (CVC) as the first choice for vascular access. AVF the cubital artery vena cephalica was performed with a standard end-to-side anastomosis with a continuous running 8-0 prolene monofilament suture. The patient was discharged on the second post operative day, subsequent to a normal AVF primary patency. We recommend that vascular and pediatric Hemodialysis centers establish a strategy supporting AVF creation in small children when peritoneal dialysis is contraindicated and pre-emptive kidney transplantation is not feasible. *Correspondence to: Dragan Piljic, M.D., Ph.D., Department of Cardiovascular Surgery, University Clinical Center Tuzla, Bosnia & Herzegovina, Tel: +38735303202; E-mail: dragan.piljic@dr.com
一名11岁女性因生长问题和慢性肾衰竭在儿科病房长期血液透析时因动静脉瘘(AVF)形成而入院。在她住院期间,继续使用套管式中心静脉导管(CVC)作为血管通路的首选。肘动脉头静脉AVF采用标准端侧吻合,连续运行8-0 prolene单丝缝合。术后第二天患者出院,AVF基本通畅。我们建议血管和儿童血液透析中心建立一个策略,支持腹膜透析禁忌和不能进行先发制人肾移植的儿童的AVF生成。*通讯:Dragan Piljic, M.D, Ph.D.,波黑图兹拉大学临床中心心血管外科,电话:+38735303202;电子邮件:dragan.piljic@dr.com
{"title":"Autologous Arteriovenous Fistula Creation for Haemodialysis in Small Children","authors":"Dragan Piljic, N. Sehic, Dilista Piljić, Fahrudin Sabanovic, M. Petricevic, G. Samoukovic","doi":"10.15761/HPC.1000203","DOIUrl":"https://doi.org/10.15761/HPC.1000203","url":null,"abstract":"A 11-years old female with growth problem and chronic renal failure was admitted for arteriovenous fistula (AVF) formation for long-term haemodialysis in the pediatric ward. During her hospital stay, continue to have a cuffed central venous catheter (CVC) as the first choice for vascular access. AVF the cubital artery vena cephalica was performed with a standard end-to-side anastomosis with a continuous running 8-0 prolene monofilament suture. The patient was discharged on the second post operative day, subsequent to a normal AVF primary patency. We recommend that vascular and pediatric Hemodialysis centers establish a strategy supporting AVF creation in small children when peritoneal dialysis is contraindicated and pre-emptive kidney transplantation is not feasible. *Correspondence to: Dragan Piljic, M.D., Ph.D., Department of Cardiovascular Surgery, University Clinical Center Tuzla, Bosnia & Herzegovina, Tel: +38735303202; E-mail: dragan.piljic@dr.com","PeriodicalId":48703,"journal":{"name":"Primary Health Care Research and Development","volume":"21 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82434443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Minimizing Collateral Damage from COVD-19 Distancing Strategies: Protecting Patients who have Multi-Morbidity 尽量减少covid -19隔离策略的附带损害:保护多重发病患者
IF 1.6 4区 医学 Q2 Nursing Pub Date : 2020-01-01 DOI: 10.15761/HPC.1000200
E. Shadmi, C. Boult, R. Balicer
Most epidemiologic models project that only a small fraction of the world’s billion people who have “multi-morbidity” (i.e., three or more chronic health conditions) [1] will succumb to COVID-19-induced mortality. Many more multi-morbid people, most of whom are older, are vulnerable to incurring “collateral damage,” i.e., deterioration and death as a result of “social-distancing” and other pandemic control strategies that are likely to continue until a vaccine becomes widely available (in mid-2021 at the earliest) [2].
大多数流行病学模型预测,在世界上10亿患有“多重疾病”(即三种或三种以上慢性健康状况)[1]的人中,只有一小部分人会死于covid -19引起的死亡。更多的多重疾病患者(其中大多数是老年人)很容易遭受“附带损害”,即由于“社交距离”和其他大流行控制策略而导致病情恶化和死亡,这些策略可能会持续到疫苗广泛获得(最早在2021年中期)[2]。
{"title":"Minimizing Collateral Damage from COVD-19 Distancing Strategies: Protecting Patients who have Multi-Morbidity","authors":"E. Shadmi, C. Boult, R. Balicer","doi":"10.15761/HPC.1000200","DOIUrl":"https://doi.org/10.15761/HPC.1000200","url":null,"abstract":"Most epidemiologic models project that only a small fraction of the world’s billion people who have “multi-morbidity” (i.e., three or more chronic health conditions) [1] will succumb to COVID-19-induced mortality. Many more multi-morbid people, most of whom are older, are vulnerable to incurring “collateral damage,” i.e., deterioration and death as a result of “social-distancing” and other pandemic control strategies that are likely to continue until a vaccine becomes widely available (in mid-2021 at the earliest) [2].","PeriodicalId":48703,"journal":{"name":"Primary Health Care Research and Development","volume":"40 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89606723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inter-Individuality and plant hormones 个体间与植物激素
IF 1.6 4区 医学 Q2 Nursing Pub Date : 2020-01-01 DOI: 10.15761/HPC.1000193
T. Trewavas
Plant hormones are organic chemicals that are synthesised either in response to environmental challenges or at discrete stages of the continuous process of plant development. They work at concentrations of 10-7 M or lower. They help coordinate growth and cell development either within a tissue or between separate tissues. These hormones, about 10 in number (cf 50 in mammals) exert distinct transcriptional and translational leverage via characterised receptors. Growing plants are very sensitive to many characteristics of their environment; changes commonly initiate cytoplasmic Ca2+ transients similar in speed and length to those in mammals. Usually these transients precede subsequent hormoneinitiated processes [1,2]. Additional control is implemented by intercellular and inter-organ movement of some proteins, mRNA’s, sRNAs, peptides probably secreted in exosomal vesicles [3-5]. Some important minerals such as nitrate and phosphate have their availability assessed through characterised receptors and alter growth and development accordingly [6,7].
植物激素是一种有机化学物质,是在应对环境挑战或在植物发育的连续过程的离散阶段合成的。它们在10-7微米或更低的浓度下工作。它们有助于协调组织内或独立组织之间的生长和细胞发育。这些激素大约有10种(哺乳动物有50种),它们通过特定的受体发挥不同的转录和翻译作用。生长中的植物对环境的许多特征非常敏感;变化通常会引发细胞质Ca2+瞬变,其速度和长度与哺乳动物相似。通常,这些短暂现象先于随后的激素启动过程[1,2]。外泌体囊泡中可能分泌的一些蛋白质、mRNA、sRNAs和肽在细胞间和器官间的运动也起到了额外的控制作用[3-5]。一些重要的矿物质,如硝酸盐和磷酸盐,其可用性通过特征受体评估,并相应地改变生长和发育[6,7]。
{"title":"Inter-Individuality and plant hormones","authors":"T. Trewavas","doi":"10.15761/HPC.1000193","DOIUrl":"https://doi.org/10.15761/HPC.1000193","url":null,"abstract":"Plant hormones are organic chemicals that are synthesised either in response to environmental challenges or at discrete stages of the continuous process of plant development. They work at concentrations of 10-7 M or lower. They help coordinate growth and cell development either within a tissue or between separate tissues. These hormones, about 10 in number (cf 50 in mammals) exert distinct transcriptional and translational leverage via characterised receptors. Growing plants are very sensitive to many characteristics of their environment; changes commonly initiate cytoplasmic Ca2+ transients similar in speed and length to those in mammals. Usually these transients precede subsequent hormoneinitiated processes [1,2]. Additional control is implemented by intercellular and inter-organ movement of some proteins, mRNA’s, sRNAs, peptides probably secreted in exosomal vesicles [3-5]. Some important minerals such as nitrate and phosphate have their availability assessed through characterised receptors and alter growth and development accordingly [6,7].","PeriodicalId":48703,"journal":{"name":"Primary Health Care Research and Development","volume":"141 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82892279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe cutaneous adverse drug reaction as a consequence of Allopurinol: The importance of HLA B58:01 testing 别嘌呤醇引起的严重皮肤药物不良反应:HLA B58:01检测的重要性
IF 1.6 4区 医学 Q2 Nursing Pub Date : 2020-01-01 DOI: 10.15761/hpc.1000180
Keshav Poddar, L. Cler
A 61-year-old Han Chinese male presented with 4-5 weeks of failure to thrive, hiccups, malaise, and fevers up to 101.5 at home. The patient had been admitted one week prior due to similar symptoms. His primary care physician recently (within 3 months) started gabapentin and chlorpromazine for hiccups, and allopurinol for gout. Drug fever was suspected, and the patient was asked to discontinue gabapentin, allopurinol and chlorpromazine. A short infectious workup for eosinophilia was negative for Herpes Simplex, Strongyloides, and Mycoplasma Pneumoniae, and he was discharged. On repeat admission he admitted to occasional use of allopurinol since his discharge home. Blood pressure was 90/50, temperature was 100.5 Degrees Fahrenheit, and heart rate was 100. Physical exam showed facial plethora, dry mucus membranes, and a diffuse morbiliform rash covering 70 percent of his body. Labs were notable for white blood cell count of 20,000 per microliter, with 6,200 eosinophils per microliter, and 31% eosinophils. Peripheral blood smear confirmed eosinophilia. A skin biopsy showed combined spongiotic and perivascular dermatitis, with eosinophils and neutrophils, all of which was consistent with Severe Cutaneous Adverse Reaction (SCAR). His symptoms quickly improved with oral prednisone. HLA B58:01 allele was positive, which is associated with allopurinol hypersensitivity. The patient was warned to avoid use of allopurinol in the future. HLA B58:01 allele testing in the Han Chinese population is routine in East Asian countries prior to treatment with allopurinol. Despite recommendations by the College of Rheumatology, testing is often overlooked.
一名61岁汉族男性在家中出现4-5周发育不良、打嗝、不适和高达101.5℃的发烧。患者因类似症状于一周前入院。他的初级保健医生最近(3个月内)开始用加巴喷丁和氯丙嗪治疗打嗝,用别嘌呤醇治疗痛风。怀疑有药热,要求停用加巴喷丁、别嘌呤醇和氯丙嗪。短暂的嗜酸性粒细胞感染检查结果为单纯疱疹、类圆形杆菌和肺炎支原体阴性,患者出院。在复诊中,他承认出院后偶尔使用别嘌呤醇。血压90/50,体温100.5华氏度,心率100。体格检查显示面部过多,粘膜干燥,弥漫性病态皮疹覆盖全身70%。实验室的白细胞计数为每微升2万个,嗜酸性粒细胞为每微升6200个,嗜酸性粒细胞为31%。外周血涂片证实嗜酸性粒细胞增多。皮肤活检显示海绵状和血管周围皮炎合并,伴有嗜酸性粒细胞和中性粒细胞,所有这些都符合严重皮肤不良反应(SCAR)。口服强的松后症状迅速好转。HLA B58:01等位基因阳性,与别嘌呤醇超敏反应相关。病人被警告以后不要再使用别嘌呤醇。在东亚国家,汉族人群在接受别嘌呤醇治疗前进行HLA B58:01等位基因检测是常规的。尽管风湿病学会(College of Rheumatology)提出了建议,但检测常常被忽视。
{"title":"Severe cutaneous adverse drug reaction as a consequence of Allopurinol: The importance of HLA B58:01 testing","authors":"Keshav Poddar, L. Cler","doi":"10.15761/hpc.1000180","DOIUrl":"https://doi.org/10.15761/hpc.1000180","url":null,"abstract":"A 61-year-old Han Chinese male presented with 4-5 weeks of failure to thrive, hiccups, malaise, and fevers up to 101.5 at home. The patient had been admitted one week prior due to similar symptoms. His primary care physician recently (within 3 months) started gabapentin and chlorpromazine for hiccups, and allopurinol for gout. Drug fever was suspected, and the patient was asked to discontinue gabapentin, allopurinol and chlorpromazine. A short infectious workup for eosinophilia was negative for Herpes Simplex, Strongyloides, and Mycoplasma Pneumoniae, and he was discharged. On repeat admission he admitted to occasional use of allopurinol since his discharge home. Blood pressure was 90/50, temperature was 100.5 Degrees Fahrenheit, and heart rate was 100. Physical exam showed facial plethora, dry mucus membranes, and a diffuse morbiliform rash covering 70 percent of his body. Labs were notable for white blood cell count of 20,000 per microliter, with 6,200 eosinophils per microliter, and 31% eosinophils. Peripheral blood smear confirmed eosinophilia. A skin biopsy showed combined spongiotic and perivascular dermatitis, with eosinophils and neutrophils, all of which was consistent with Severe Cutaneous Adverse Reaction (SCAR). His symptoms quickly improved with oral prednisone. HLA B58:01 allele was positive, which is associated with allopurinol hypersensitivity. The patient was warned to avoid use of allopurinol in the future. HLA B58:01 allele testing in the Han Chinese population is routine in East Asian countries prior to treatment with allopurinol. Despite recommendations by the College of Rheumatology, testing is often overlooked.","PeriodicalId":48703,"journal":{"name":"Primary Health Care Research and Development","volume":"42 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90761414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Melamine detection using a paper microfluidic device 三聚氰胺检测用纸微流体装置
IF 1.6 4区 医学 Q2 Nursing Pub Date : 2020-01-01 DOI: 10.15761/HPC.1000199
Wu Rg, Zhong Zw, Ankit, Chee Jy, C. Wang, Funk Kf
A study of the paper-based microfluidic devices was carried out for melamine detection. Paper-based microfluidic detection was chosen for the experiments, as it could be the most cost effective, compared to other detection techniques, which would require expensive instruments. Experimental results revealed a very good depletion of bovine serum albumin from the target analyte (melamine). UV-vis absorbance value curves of the mixture solution and extraction solution showed the extraction of the small molecule (melamine) by the developed paper microfluidic device. It is concluded that the H-filter can be used for determination of adulterated melamine in dairy products.
对纸基微流控装置进行了三聚氰胺检测研究。实验选择基于纸张的微流体检测,因为与需要昂贵仪器的其他检测技术相比,它可能是最具成本效益的。实验结果显示牛血清白蛋白从目标分析物(三聚氰胺)中损耗非常好。混合液和萃取液的紫外可见吸光度曲线显示了所研制的纸微流控装置对小分子(三聚氰胺)的提取效果。结果表明,h型过滤器可用于乳制品中掺假三聚氰胺的检测。
{"title":"Melamine detection using a paper microfluidic device","authors":"Wu Rg, Zhong Zw, Ankit, Chee Jy, C. Wang, Funk Kf","doi":"10.15761/HPC.1000199","DOIUrl":"https://doi.org/10.15761/HPC.1000199","url":null,"abstract":"A study of the paper-based microfluidic devices was carried out for melamine detection. Paper-based microfluidic detection was chosen for the experiments, as it could be the most cost effective, compared to other detection techniques, which would require expensive instruments. Experimental results revealed a very good depletion of bovine serum albumin from the target analyte (melamine). UV-vis absorbance value curves of the mixture solution and extraction solution showed the extraction of the small molecule (melamine) by the developed paper microfluidic device. It is concluded that the H-filter can be used for determination of adulterated melamine in dairy products.","PeriodicalId":48703,"journal":{"name":"Primary Health Care Research and Development","volume":"58 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85269253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Avoidable hospitalization of children from ambulatory care sensitive conditions in Barbados: a measure of the access and uptake of primary health care 在巴巴多斯,可避免的因流动护理条件敏感而住院的儿童:获得和接受初级保健的一项措施
IF 1.6 4区 医学 Q2 Nursing Pub Date : 2020-01-01 DOI: 10.15761/HPC.1000197
Alok Kumar, G. Benskin, Richa Sharma
Background and Objective : Hospitalization from avoidable causes refers to hospitalizations for an Ambulatory Care Sensitive (ACS) condition and is considered to be a measure of access to appropriate primary health care. While not all admissions for these conditions are avoidable, timely ambulatory care could temper the disease course and thus prevent progression to where hospitalization is medically indicated. A disproportionately high rate of ACS conditions may reflect problems in access to timely primary care. In this study we determine the proportion of all medical admissions in children that were from ACS Conditions (ASSC's) and therefore avoidable. We also study the trend in the proportion of avoidable hospitalizations. Method: This study is a population based prospective clinical audit of children (Age <16 years) admitted to the Queen Elizabeth Hospital (QEH). The study period extends from the year 2013 through 2017. The pediatric-specific ACS conditions employed in this analysis were based on prior studies. All the children between the ages of 3 month and 15 years where one of the discharge diagnosis was an ACS condition were included in this study. Result: During the five years study period there were a total of 19349 children (<16 years) hospitalized for medical conditions to the QEH. Over the same period, there were a total of 4235 hospitalizations from ACSC’s which accounted for 21.89% of all medical hospitalizations in children. Among the ACSC’s as the cause of hospitalization, acute asthma (6.88%) and acute asthma complicated by respiratory tract infections (2.24%) was the commonest cause for avoidable hospitalizations in children. This was followed by admissions from acute gastroenteritis and dehydration (2.89%). Children less than 4 years in age accounted for 51% of all avoidable medical hospitalizations in children. Conclusion : Over a fifth of all the medical hospitalizations in children are from the ACSC’s and are therefore avoidable.
背景和目的:可避免原因住院是指因门诊护理敏感(ACS)疾病住院,被认为是获得适当初级卫生保健的一种措施。虽然并非所有这些情况的入院都是可以避免的,但及时的门诊治疗可以缓和病程,从而防止病情发展到医学上需要住院治疗的地步。不成比例的高ACS发病率可能反映了及时获得初级保健的问题。在这项研究中,我们确定了来自ACS条件(ASSC's)的所有住院儿童的比例,因此可以避免。我们还研究了可避免住院比例的趋势。方法:本研究是对伊丽莎白女王医院(QEH)入院的儿童(年龄<16岁)进行基于人群的前瞻性临床审核。研究时间从2013年到2017年。本分析中采用的儿科特异性ACS条件是基于先前的研究。所有年龄在3个月至15岁之间且其中一项出院诊断为ACS的儿童均被纳入本研究。结果:在5年的研究期间,共有19349名儿童(<16岁)因健康状况住院。在同一时期,ACSC共有4235人住院,占所有儿童医疗住院的21.89%。在可避免的住院原因中,急性哮喘(6.88%)和急性哮喘合并呼吸道感染(2.24%)是儿童最常见的住院原因。其次是急性肠胃炎和脱水(2.89%)。在所有可避免的儿童医疗住院中,4岁以下儿童占51%。结论:在所有住院儿童中,有五分之一以上是来自ACSC,因此是可以避免的。
{"title":"Avoidable hospitalization of children from ambulatory care sensitive conditions in Barbados: a measure of the access and uptake of primary health care","authors":"Alok Kumar, G. Benskin, Richa Sharma","doi":"10.15761/HPC.1000197","DOIUrl":"https://doi.org/10.15761/HPC.1000197","url":null,"abstract":"Background and Objective : Hospitalization from avoidable causes refers to hospitalizations for an Ambulatory Care Sensitive (ACS) condition and is considered to be a measure of access to appropriate primary health care. While not all admissions for these conditions are avoidable, timely ambulatory care could temper the disease course and thus prevent progression to where hospitalization is medically indicated. A disproportionately high rate of ACS conditions may reflect problems in access to timely primary care. In this study we determine the proportion of all medical admissions in children that were from ACS Conditions (ASSC's) and therefore avoidable. We also study the trend in the proportion of avoidable hospitalizations. Method: This study is a population based prospective clinical audit of children (Age <16 years) admitted to the Queen Elizabeth Hospital (QEH). The study period extends from the year 2013 through 2017. The pediatric-specific ACS conditions employed in this analysis were based on prior studies. All the children between the ages of 3 month and 15 years where one of the discharge diagnosis was an ACS condition were included in this study. Result: During the five years study period there were a total of 19349 children (<16 years) hospitalized for medical conditions to the QEH. Over the same period, there were a total of 4235 hospitalizations from ACSC’s which accounted for 21.89% of all medical hospitalizations in children. Among the ACSC’s as the cause of hospitalization, acute asthma (6.88%) and acute asthma complicated by respiratory tract infections (2.24%) was the commonest cause for avoidable hospitalizations in children. This was followed by admissions from acute gastroenteritis and dehydration (2.89%). Children less than 4 years in age accounted for 51% of all avoidable medical hospitalizations in children. Conclusion : Over a fifth of all the medical hospitalizations in children are from the ACSC’s and are therefore avoidable.","PeriodicalId":48703,"journal":{"name":"Primary Health Care Research and Development","volume":"69 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89208430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Talking about prejudice. A project for the nursing courses 说到偏见。一个护理课程的项目
IF 1.6 4区 医学 Q2 Nursing Pub Date : 2020-01-01 DOI: 10.15761/HPC.1000196
Gradellini Cinzia
- The literature suggests nursing courses in to adopt curricula to support the specific competences requested to care migrants. - One of the recommended topic is the consciousness’ promotion of the prejudice, because it becomes the key component of several problems: coexistence, acceptance, communication, and discrimination. - The described teaching module “Talking About Prejudice”, planned for the nursing courses, has the objective to develop the consciousness of the tendency to generalize people, to, finally, arrive at the prejudice management.
-文献建议护理课程应采用课程来支持护理移民所需的具体能力。-其中一个推荐的主题是偏见的意识提升,因为它成为几个问题的关键组成部分:共存,接受,沟通和歧视。-所描述的“谈论偏见”教学模块是为护理课程设计的,其目的是培养人们对泛化倾向的意识,最终达到偏见管理。
{"title":"Talking about prejudice. A project for the nursing courses","authors":"Gradellini Cinzia","doi":"10.15761/HPC.1000196","DOIUrl":"https://doi.org/10.15761/HPC.1000196","url":null,"abstract":"- The literature suggests nursing courses in to adopt curricula to support the specific competences requested to care migrants. - One of the recommended topic is the consciousness’ promotion of the prejudice, because it becomes the key component of several problems: coexistence, acceptance, communication, and discrimination. - The described teaching module “Talking About Prejudice”, planned for the nursing courses, has the objective to develop the consciousness of the tendency to generalize people, to, finally, arrive at the prejudice management.","PeriodicalId":48703,"journal":{"name":"Primary Health Care Research and Development","volume":"53 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73576140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
Primary Health Care Research and Development
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1