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Hot Topics of Molecular and Cellular Biomechanics in 2022 2022年分子与细胞生物力学热点话题
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-09-29 DOI: 10.32604/mcb.2023.044564
Guixue Wang
The analysis of biomechanical characteristics plays an important role in mastering the technical characteristics of athletes, providing guidance for the formulation and prevention of sports injury training plans and providing theoretical support for research on injury prevention and stability control in the sports field. With the importance of data analysis, the application scope of artificial intelligence methods is more extensive. For example, intelligent training systems can be used for athletes’ personalized and professional training, real-time monitoring and feedback of training data, and further reduce the risk of sports injury. However, deep learning methods process a large number of medical images to identify and predict diseases such as cancer.
生物力学特性的分析对于掌握运动员的技术特性,指导运动损伤训练计划的制定和预防,为运动领域损伤预防和稳定性控制的研究提供理论支持具有重要作用。随着数据分析的重要性,人工智能方法的应用范围更加广泛。例如,智能训练系统可以用于运动员的个性化和专业化训练,实时监控和反馈训练数据,进一步降低运动损伤的风险。然而,深度学习方法需要处理大量的医学图像来识别和预测癌症等疾病。
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引用次数: 0
CFD Study on Hemodynamic Characteristics of Inferior Vena Cava Filter Affected by Blood Vessel Diameter 下腔静脉过滤器血流动力学特性受血管直径影响的CFD研究
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-01-01 DOI: 10.32604/mcb.2023.044445
Shiyue Zhang, Xue Song, Jingying Wang, Wen Huang, Yue Zhou, Mingrui Li
Pulmonary embolism (PE), caused by deep venous thrombosis (DVT), is a disease with high morbidity and mortality. Implantation of inferior vena cava filters is an important method for the clinical prevention of PE. The hemodynamic characteristics of filters implanted in the inferior vena cava (IVC) have a significant impact on their performance. However, IVC diameters vary among patients. This may have a direct impact on the hemodynamic properties of the filter. At present, there is no research on this kind of problem to be investigated. In this paper, the hemodynamic properties of the VenaTech convertible filter were simulated in three different IVC models of 15, 20 and 25 mm diameters, using computational fluid dynamics (CFD) as a control variable (only the IVC diameter is varied). The results showed that the diameter has a significant impact on the hemodynamic characteristics after filter implantation. The IVC diameter has a great influence on the stagnation zone of the blood flow, the maximum wall shear stress (WSS) on the upstream side along the filter wire, and the flow resistance. The case of 15 mm diameter was the most prone to thrombus formation downstream of the filter head in the IVC, but the larger WSS on the upstream along the filter wire may facilitate thrombus lysis. Therefore, the change in vessel diameter should be considered when performing filter implantation for patients.
肺动脉栓塞(PE)是由深静脉血栓形成(DVT)引起的一种高发病率和死亡率的疾病。下腔静脉滤器植入术是临床预防PE的重要方法。植入下腔静脉的滤嘴的血流动力学特性对滤嘴的性能有重要影响。然而,不同患者的下腔静脉直径不同。这可能对过滤器的血流动力学特性有直接影响。目前,还没有关于这类问题的研究。本文采用计算流体动力学(CFD)作为控制变量(仅改变内腔直径),在直径为15、20和25 mm的三种不同的内腔模型中模拟了VenaTech可转换过滤器的血流动力学特性。结果表明,滤嘴直径对滤嘴植入后的血流动力学特性有显著影响。下腔静脉直径对血流停滞区、沿滤丝上游最大壁面剪切应力(WSS)和流动阻力有较大影响。直径为15mm的情况下,下腔静脉滤头下游最容易形成血栓,但沿滤丝上游较大的WSS可能有利于血栓溶解。因此,在对患者进行滤镜植入时,应考虑血管直径的变化。
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引用次数: 0
Reconstruction of the Hindlimb Locomotion of Confuciusornis (Aves) and Its Implication for the Origin of Avian Flight 孔子鸟后肢运动的重建及其对鸟类飞行起源的启示
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-01-01 DOI: 10.32604/mcb.2023.041173
Xinsen Wei, Ying Guo, Yan Zhao
As one of the most basal avian clades, the Confuciusornithids are ideal in revealing the early evolution of avian flight. Birds’ hindlimbs are functionally diverse and contain a wealth of information about their behavior. The hindlimb of Confuciusornis, however, has only been studied in detail in terms of functional morphology, and quantitative studies that directly assess locomotor ability are relatively lacking. This has led to certain controversies on the behavior of Confuciusornis. This paper reviews the debates over the life habits and take-off ability of Confuciusornis, which are closely related to their hindlimb function. Several methodologies adopted engineering techniques, including the geometrical analysis of long bones, physiological reconstruction of muscles, kinematic and kinetic characteristics estimating, and appendage locomotor mechanism analysis, are recommended for estimating the hindlimb functions of Confuciusornis. Considering that the fossil bones are fragile, irregular in shape, and usually deformed, it is appropriate to apply computer numerical simulation techniques to such studies. A sufficient functional quantitative study will help clarify early bird locomotor behavior, which will provide clues and evidence for further exploration of the origin of bird flight and early bird movement.
孔子鸟目是鸟类最基础的分支之一,是揭示鸟类飞行早期进化的理想分支。鸟类的后肢功能多样,包含了大量关于它们行为的信息。然而,目前对孔子鸟后肢的研究仅在功能形态学方面进行了详细的研究,直接评估其运动能力的定量研究相对缺乏。这就导致了对孔子行为的一些争议。本文综述了关于孔子鸟的生活习性和起飞能力的争论,这与孔子鸟的后肢功能密切相关。采用工程技术,包括长骨的几何分析、肌肉的生理重建、运动学和动力学特征的估计以及附肢运动机制的分析,推荐了几种方法来估计孔子鸟的后肢功能。考虑到化石骨骼易碎,形状不规则,通常会变形,因此将计算机数值模拟技术应用于此类研究是合适的。充分的功能定量研究将有助于厘清早期鸟类的运动行为,为进一步探索鸟类飞行和早期鸟类运动的起源提供线索和证据。
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引用次数: 0
Can PAPE-Induced Increases in Jump Height Be Explained by Jumping Kinematics? pape引起的跳高是否可以用跳跃运动学来解释?
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-01-01 DOI: 10.32604/mcb.2023.042910
Xiaojie Jiang, Xin Li, Yining Xu, Dong Sun, Julien S. Baker, Yaodong Gu
The aim of this study was to investigate whether kinematic data during a countermovement jump (CMJ) could explain the post-activation performance enhancement (PAPE) effects following acute resistance exercise. Twenty-four male participants with resistance training and jumping experience were recruited and randomly assigned to either the experimental group (PAPE-stimulus) (n = 12) or the control group (n = 12). In the experimental group, participants performed 5 reps of squats at 80% 1RM to induce PAPE, while the control group received no intervention. Both groups performed three CMJ tests before (PRE) and at immediate (POST0), 4 (POST4), 8 (POST8), and 12 (POST12) min after the intervention, with kinematic data recorded during the CMJ. Kinematic parameters analyzed in this study included jump height, hip-knee-ankle flexion angles at the lowest position of the countermovement, eccentric and concentric time durations, and the temporal changes of hip-knee-ankle flexion angles during the entire jumping phase. The presence of PAPE was determined by the change in jump height. The results showed that in the experimental group, jump height significantly increased at POST4 (p < 0.001) and POST8 (p < 0.001) and significantly decreased at POST0 (p = 0.008), with no significant change at POST12. The control group showed no significant changes at any measured time point. Kinematic parameters showed that there was no significant difference in joint flexion angle of the lower body during the CMJ between pre- and post-intervention, regardless of PAPE or fatigue. However, eccentric time significantly decreased at 4 and 8 min (p = 0.013 and p = 0.001, respectively) after the intervention. These findings suggest that PAPE-induced increases in jump height after acute resistance exercise can be attributed to the decrease in eccentric phase duration, but not joint flexion angle. Additionally, the fatigue-induced decrease in jump height cannot be reflected by jumping kinematics. Based on these findings, coaches may use complex training to utilize the PAPE effects to increase jump height while reducing the eccentric time during vertical jumps. This method can enhance an athlete’s eccentric ability to generate force in a short amount of time which is crucial for performance enhancement.
本研究的目的是探讨反向运动跳跃(CMJ)期间的运动学数据是否可以解释急性阻力运动后的激活后性能增强(PAPE)效应。招募24名具有抗阻训练和跳跃经验的男性参与者,随机分为实验组(n = 12)和对照组(n = 12)。实验组在80% 1RM下做5次深蹲诱导PAPE,对照组不进行干预。两组均在干预前(PRE)和即刻(POST0)、4 (POST4)、8 (POST8)和12 (POST12) min进行三次CMJ测试,并记录CMJ期间的运动学数据。本研究分析的运动学参数包括起跳高度、髋关节-膝关节-踝关节在反动作最低位置的屈曲角度、偏心和同心持续时间以及整个跳跃阶段髋关节-膝关节-踝关节屈曲角度的时间变化。PAPE的存在是由跳跃高度的变化决定的。结果表明,实验组的跳高在POST4 (p < 0.001)和POST8 (p < 0.001)显著升高,在POST0 (p = 0.008)显著降低,在POST12无显著变化。对照组在任何测量时间点均无明显变化。运动学参数显示,无论是否存在PAPE或疲劳,干预前后CMJ期间下体关节屈曲角度均无显著差异。然而,干预后的偏心时间在4和8分钟显著减少(p = 0.013和p = 0.001)。这些结果表明,急性阻力运动后pape诱导的跳跃高度增加可归因于偏心相持续时间的减少,而不是关节屈曲角的减少。此外,疲劳引起的跳跃高度下降不能通过跳跃运动学反映出来。基于这些发现,教练员可以通过复杂的训练来利用PAPE效应来提高起跳高度,同时减少垂直起跳时的偏心时间。这种方法可以提高运动员在短时间内产生力量的古怪能力,这对提高成绩至关重要。
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引用次数: 0
Nuclear Stress-Strain State over Micropillars: A Mechanical In silico Study 微柱上的核应力-应变状态:一个机械的计算机研究
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-01-01 DOI: 10.32604/mcb.2022.018958
R. Allena, D. Aubry
Cells adapt to their environment and stimuli of different origin. During confined migration through sub-cellular and sub-nuclear pores, they can undergo large strains and the nucleus, the most voluminous and the stiffest organelle, plays a critical role. Recently, patterned microfluidic devices have been employed to analyze the cell mechanical behavior and the nucleus self-deformations. In this paper, we present an in silico model to simulate the interactions between the cell and the underneath microstructured substrate under the effect of the sole gravity. The model lays on mechanical features only and it has the potential to assess the contribution of the nuclear mechanics on the cell global behavior. The cell is constituted by the membrane, the cytosol, the lamina, and the nucleoplasm. Each organelle is described through a constitutive law defined by specific mechanical parameters, and it is composed of a fluid and a solid phase leading to a viscoelastic behavior. Our main objective is to evaluate the influence of such mechanical components on the nucleus behavior. We have quantified the stress and strain distributions in the nucleus, which could be responsible of specific phenomena such as the lamina rupture or the expression of stretch-sensitive proteins.
细胞适应不同来源的环境和刺激。在通过亚细胞和亚核孔的受限迁移过程中,它们可以承受较大的应变,而核作为体积最大、最坚硬的细胞器起着至关重要的作用。近年来,图形微流控装置被用于分析细胞的力学行为和细胞核的自变形。在本文中,我们提出了一个硅模型来模拟在鞋底重力作用下细胞与底部微结构衬底之间的相互作用。该模型只考虑力学特征,它有潜力评估核力学对细胞整体行为的贡献。细胞由膜、细胞质、层和核质组成。每个细胞器都通过由特定力学参数定义的本构定律来描述,并且它由流体和固相组成,导致粘弹性行为。我们的主要目的是评估这些机械部件对原子核行为的影响。我们已经量化了核内的应力和应变分布,这可能是导致板断裂或拉伸敏感蛋白表达等特定现象的原因。
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引用次数: 1
Classification of Leukemia and Leukemoid Using VGG-16 Convolutional Neural Network Architecture 基于VGG-16卷积神经网络架构的白血病和类白血病分类
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-01-01 DOI: 10.32604/mcb.2022.016966
G. Sriram, T. R. Ganesh Babu, R. Praveena, J. V. Anand
Leukemoid reaction like leukemia indicates noticeable increased count of WBCs (White Blood Cells) but the cause of it is due to severe inflammation or infections in other body regions. In automatic diagnosis in classifying leukemia and leukemoid reactions, ALL IDB2 (Acute Lymphoblastic Leukemia-Image Data Base) dataset has been used which comprises 110 training images of blast cells and healthy cells. This paper aimed at an automatic process to distinguish leukemia and leukemoid reactions from blood smear images using Machine Learning. Initially, automatic detection and counting of WBC is done to identify leukocytosis and then an automatic detection of WBC blasts is performed to support classification of leukemia and leukemoid reactions. Leukocytosis is commonly observed both in leukemia and leukemoid hence physicians may have chance of wrong diagnosis of malignant leukemia for the patients with leukemoid reactions. BCCD (blood cell count detection) Dataset has been used which has 364 blood smear images of which 349 are of single WBC type. The Image segmentation algorithm of Hue Saturation Value color based on watershed has been applied. VGG16 (Visual Geometric Group) CNN (Convolution Neural Network) architecture based deep learning technique is being incorporated for classification and counting WBC type from segmented images. The VGG16 architecture based CNN used for classification and segmented images obtained from first part were tested to identify WBC blasts.
类白血病反应,如白血病,表明白细胞计数明显增加,但其原因是由于身体其他部位的严重炎症或感染。在白血病和类白血病反应分类的自动诊断中,使用了ALL IDB2 (Acute Lymphoblastic leukemia - image database)数据集,该数据集包含110张原始细胞和健康细胞的训练图像。本文旨在利用机器学习从血液涂片图像中自动区分白血病和白血病样反应。最初,自动检测和计数白细胞是为了确定白细胞增多,然后自动检测白细胞母细胞,以支持白血病和类白血病反应的分类。白细胞增多症在白血病和类白血病中都很常见,因此对于有类白血病反应的患者,医生可能有误诊为恶性白血病的机会。使用BCCD(血细胞计数检测)数据集,该数据集有364张血液涂片图像,其中349张为单一白细胞类型。应用了基于分水岭的色相饱和度值图像分割算法。VGG16 (Visual Geometric Group)基于卷积神经网络(CNN)架构的深度学习技术被用于从分割图像中分类和计数WBC类型。使用基于VGG16架构的CNN进行分类,并对第一部分得到的分割图像进行测试,对WBC爆炸进行识别。
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引用次数: 6
Lung Nodule Detection Based on YOLOv3 Deep Learning with Limited Datasets 基于YOLOv3深度学习的有限数据集肺结节检测
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-01-01 DOI: 10.32604/mcb.2022.018318
Zhaohui Bu, Xuejun Zhang, Jianxiang Lu, Huan Lao, Chan Liang, Xianfu Xu, Yini Wei, Hongjie Zeng
The early symptom of lung tumor is always appeared as nodule on CT scans, among which 30% to 40% are malignant according to statistics studies. Therefore, early detection and classification of lung nodules are crucial to the treatment of lung cancer. With the increasing prevalence of lung cancer, large amount of CT images waiting for diagnosis are huge burdens to doctors who may missed or false detect abnormalities due to fatigue. Methods: In this study, we propose a novel lung nodule detection method based on YOLOv3 deep learning algorithm with only one preprocessing step is needed. In order to overcome the problem of less training data when starting a new study of Computer Aided Diagnosis (CAD), we firstly pick up a small number of diseased regions to simulate a limited datasets training procedure: 5 nodule patterns are selected and deformed into 110 nodules by random geometric transformation before fusing into 10 normal lung CT images using Poisson image editing. According to the experimental results, the Poisson fusion method achieves a detection rate of about 65.24% for testing 100 new images. Secondly, 419 slices from common database RIDER are used to train and test our YOLOv3 network. The time of lung nodule detection by YOLOv3 is shortened by 2–3 times compared with the mainstream algorithm, with the detection accuracy rate of 95.17%. Finally, the configuration of YOLOv3 is optimized by the learning data sets. The results show that YOLOv3 has the advantages of high speed and high accuracy in lung nodule detection, and it can access a large amount of CT image data within a short time to meet the huge demand of clinical practice. In addition, the use of Poisson image editing algorithms to generate data sets can reduce the need for raw training data and improve the training efficiency.
肺肿瘤的早期症状在CT扫描上多表现为结节,据统计,其中30% ~ 40%为恶性。因此,早期发现和分类肺结节对肺癌的治疗至关重要。随着肺癌患病率的增加,大量等待诊断的CT图像给医生带来了巨大的负担,医生可能会因疲劳而漏诊或误检异常。方法:在本研究中,我们提出了一种基于YOLOv3深度学习算法的肺结节检测新方法,只需要一个预处理步骤。为了克服计算机辅助诊断(CAD)新研究开始时训练数据较少的问题,我们首先选取少量病变区域,模拟有限数据集的训练过程:选择5个结节模式,通过随机几何变换变形为110个结节,然后使用泊松图像编辑融合到10个正常肺CT图像中。实验结果表明,泊松融合方法对100幅新图像的检测率约为65.24%。其次,使用来自公共数据库RIDER的419个切片来训练和测试YOLOv3网络。与主流算法相比,YOLOv3对肺结节的检测时间缩短了2-3倍,检测准确率为95.17%。最后,利用学习数据集对YOLOv3的配置进行优化。结果表明,YOLOv3在肺结节检测方面具有速度快、准确率高的优点,可在短时间内获取大量CT图像数据,满足临床实践的巨大需求。此外,使用泊松图像编辑算法生成数据集可以减少对原始训练数据的需求,提高训练效率。
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引用次数: 2
Effect of Resistance Training and Spirulina platensis on Expression of IL-6, Gp130 Cytokines, JAK-STAT Signaling in Male Rats Skeletal Muscle 阻力训练和螺旋藻对雄性大鼠骨骼肌IL-6、Gp130细胞因子及JAK-STAT信号表达的影响
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-01-01 DOI: 10.32604/mcb.2022.018345
A. Zar, F. Ahmadi, F. Karimi, M. Ahmadi, R. Ramsbottom
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引用次数: 0
Comparative Study on Biomechanics of Two Legs in the Action of Single-Leg Landing in Men’s Badminton 男子羽毛球单腿落地动作双腿生物力学比较研究
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-01-01 DOI: 10.32604/mcb.2022.017044
Gang He
This study aims to analyze the biomechanical difference between the two legs of male badminton players when they land on one leg, thereby providing some guidance for preventing sports injury. Ten male badminton players were selected as the subjects. They did the single-leg landing movement successfully three times. The kinematic data were obtained by the Vicon infrared high-speed motion capture system. The kinetic data were obtained by the KISTLER three-dimensional forcing measuring platform. The data were processed and analyzed. The center of gravity of the right leg on the X and Y axes were 0.25 ± 0.05 and 0.21 ± 0.04 m, respectively, which were lower than that of the left leg (p < 0.05). At the moment of landing by a single leg, the hip angle of the left and right legs was 164.78 ± 6.12° and 156.29 ± 6.89°, respectively (p < 0.05), the hip joint speed of the left and right legs was 2.21 ± 0.32 and 1.98 ± 0.31 m/s, respectively (p < 0.05), the knee joint speed of the left and right legs was 2.51 ± 0.21 and 2.21 ± 0.21 m/s, respectively (p < 0.05). Although there was no significant difference in the range of joint motion, the motion range of the right leg was larger than that of the left leg, and the buffering time of the knee joint of the right leg was also significantly less than that of the left leg. The comparison of the kinetic data demonstrated that the ground reaction force (GRF), peak vertical ground reaction force (PVGRF), and lower limb stiffness of the right leg were significantly smaller than those of the left leg, and the time to peak force was greater than that of the left leg (p < 0.05). The injury risk of the left leg is greater than that of the right leg when the athlete land on a single leg. In the process of training, the athlete should strengthen the stability training of two legs, especially the left leg, in order to reduce sports injury.
本研究旨在分析男子羽毛球运动员单腿着地时两腿的生物力学差异,从而为预防运动损伤提供一定的指导。选取10名男子羽毛球运动员作为研究对象。他们成功地做了三次单腿着地动作。运动学数据由Vicon红外高速运动捕捉系统获取。动力学数据由KISTLER三维力测量平台获得。对数据进行了处理和分析。右腿X、Y轴重心分别为0.25±0.05、0.21±0.04 m,均低于左腿(p < 0.05)。单腿着地时,左右腿髋关节角度分别为164.78±6.12°和156.29±6.89°(p < 0.05),左右腿髋关节速度分别为2.21±0.32和1.98±0.31 m/s (p < 0.05),左右腿膝关节速度分别为2.51±0.21和2.21±0.21 m/s (p < 0.05)。虽然在关节活动范围上没有明显差异,但右腿的活动范围大于左腿,右腿膝关节的缓冲时间也明显小于左腿。动力学数据对比发现,右腿的地面反力(GRF)、垂直地面反力峰值(PVGRF)和下肢刚度均显著小于左腿,且力峰值时间大于左腿(p < 0.05)。当运动员单腿着地时,左腿受伤的风险大于右腿。在训练过程中,运动员应加强两条腿尤其是左腿的稳定性训练,以减少运动损伤。
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引用次数: 0
Analysis of the Movement Track of Top Spinning Ball and Biomechanics in the Process of Hitting Tennis Ball 网球击球过程中高旋球运动轨迹及生物力学分析
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-01-01 DOI: 10.32604/mcb.2021.016246
Xia Xie
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引用次数: 0
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Molecular & Cellular Biomechanics
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