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Cooperative spatial modelling of hospital compliance with minimum caseload requirements. 符合最低病例量要求的医院合作空间模型。
IF 3 2区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-01-27 DOI: 10.1186/s12942-025-00442-6
Limei Ji, Max Geraedts, Werner de Cruppé

Background: Minimum caseload requirements (MCRs) ensure medical treatment quality but may negatively affect spatial accessibility to health care. Previous studies optimised the caseload distribution via spatial models, with a focus on balancing spatial concentration and accessibility with centralised case redistribution models. This study seeks to capture hospitals as active participants in MCR policy decisions by incorporating their intentions and motivations regarding MCRs within their spatial context, considering current caseloads and neighbouring hospital distances.

Methods: The study modelled four MCR procedures separately in an individual model in accordance with the German policy context: complex oesophageal interventions, complex pancreatic interventions, stem cell transplantation, and total knee replacement. The spatial model for Germany involved three steps: (1) delimiting cooperating hospitals, (2) iterative grouping, and (3) categorising hospital groups.

Results: The grouping process described above resulted in 55 (oesophagus), 126 (pancreas), 39 (stem cell), and 672 (knee) groups across Germany. A total of 50.9%, 49.2%, 51.3%, and 81.5% respectively of these groups contained only one hospital (no cooperation needed). 7, 28, 2, and 22 groups require joint MCR compliance, whereas 19, 21, 8, and 8 hospitals are recommended special permission with a reduced caseload threshold to ensure spatial accessibility for certain regions. The results inform regional policy makers based on the hospital decision space.

Conclusions: This study models potential hospital cooperation based on proximity and caseload, introducing joint MCR compliance. The modelling process supports the formation, categorisation, and analysis of hospital groups, with parameter thresholds enabling flexible policy testing. This approach considers hospitals' intentions and motivations regarding MCRs, and reserves their decision space. This spatial model provides a theoretical basis for granting exceptional MCR permissions to improve spatial accessibility.

背景:最低病例负荷要求(mcr)确保医疗质量,但可能对卫生保健的空间可达性产生负面影响。以往的研究通过空间模型来优化病例负荷分布,重点是通过集中的病例再分配模型来平衡空间集中度和可达性。考虑到当前的病例量和邻近医院的距离,本研究试图通过将医院关于MCR的意图和动机纳入其空间背景,将医院作为MCR政策决策的积极参与者。方法:该研究根据德国政策背景,在个体模型中分别模拟了四种MCR过程:复杂的食管干预、复杂的胰腺干预、干细胞移植和全膝关节置换术。德国的空间模型包括三个步骤:(1)划分合作医院,(2)迭代分组,(3)对医院组进行分类。结果:上述分组过程在德国产生了55组(食道),126组(胰腺),39组(干细胞)和672组(膝关节)。分别为50.9%、49.2%、51.3%和81.5%的组仅包含一家医院(不需要合作)。7、28、2和22家医院需要联合遵守MCR,而19、21、8和8家医院建议获得特别许可,降低病例量阈值,以确保某些地区的空间可达性。结果为基于医院决策空间的区域决策者提供了信息。结论:本研究基于邻近度和病例量对潜在的医院合作进行建模,引入联合MCR依从性。建模过程支持医院组的形成、分类和分析,参数阈值支持灵活的政策测试。这种方法考虑了医院对mcr的意图和动机,并保留了他们的决策空间。该空间模型为授予例外MCR权限以提高空间可达性提供了理论基础。
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引用次数: 0
The role of residential urban form and built environment in supporting social interaction, health, and well-being: a focus on forming and maintaining ties. 住宅城市形态和建筑环境在支持社会互动、健康和福祉方面的作用:重点是形成和维持联系。
IF 3 2区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-01-27 DOI: 10.1186/s12942-026-00451-z
Taiyo Ishikawa, Marketta Kyttä, Tiina Rinne

Background: Social interaction is essential for health and well-being, given the growing public health concern of social isolation and loneliness. The role of the built environment in supporting social interaction has been widely studied. However, previous research has often treated social interaction as a single, undifferentiated category, although different types of interaction may serve distinct social functions and be influenced by different environmental factors. Moreover, most studies have focused primarily on residential neighborhood contexts. This study addresses these key gaps by distinguishing between two types of social interaction-tie formation and tie maintenance-and by examining built environment characteristics across broader, individualized multidimensional activity space models.

Method: Using data from a Public Participatory GIS (PPGIS) survey (n = 386) in Turku, Finland, this study analyzed how residential urban form and built environment features relate to tie formation and tie maintenance. Built environment features were assessed using three activity space models: 500-meter home buffer, combined buffer around home and daily destinations, and individualized activity range spanning between home and destinations. Structural Equation Modeling was used to examine how these factors influence each type of social interaction and associated psychosocial outcomes.

Results: Residing in urban areas was significantly associated with tie maintenance but not with tie formation. Walkability around the home supported both types of interaction, whereas parks and green spaces near daily destinations were positively associated with tie formation. A similar pattern was observed within individualized activity ranges, where park ratio predicted tie formation. These two types of social interaction influenced psychosocial outcomes through distinct pathways: tie formation had direct positive effects on health and well-being, while tie maintenance contributed indirectly through increased relationship satisfaction.

Conclusion: The findings emphasize the importance of distinguishing between different types of social interaction and accounting for their unique spatial and functional drivers. Urban planning and public health efforts should consider how different aspects of the built environment foster both the formation and maintenance of social ties. Promoting environments that support diverse forms of social interaction is essential not only for enhancing health and well-being but also for reducing the risk of loneliness.

背景:鉴于社会孤立和孤独对公共卫生的日益关注,社会互动对健康和福祉至关重要。建筑环境在支持社会互动中的作用已被广泛研究。然而,以往的研究往往将社会互动视为单一的、未区分的类别,尽管不同类型的互动可能具有不同的社会功能,并受到不同环境因素的影响。此外,大多数研究主要集中在住宅社区背景。本研究通过区分两种类型的社会互动——关系形成和关系维护——以及通过更广泛、个性化的多维活动空间模型研究建筑环境特征来解决这些关键差距。方法:利用来自芬兰图尔库的公共参与式地理信息系统(PPGIS)调查(n = 386)的数据,本研究分析了住宅城市形态和建筑环境特征与领带形成和维护之间的关系。使用三种活动空间模型对建成环境特征进行了评估:500米的家庭缓冲,家庭和日常目的地周围的联合缓冲,以及家庭和目的地之间的个性化活动范围。结构方程模型用于检验这些因素如何影响每种类型的社会互动和相关的社会心理结果。结果:居住在城市地区与领带维持显著相关,但与领带形成无关。家周围的可步行性支持这两种类型的互动,而每天目的地附近的公园和绿地则与这种互动形成呈正相关。在个人活动范围内观察到类似的模式,其中公园比例预测了领带的形成。这两种类型的社会互动通过不同的途径影响心理社会结果:领带的形成对健康和幸福有直接的积极影响,而领带的维持通过增加关系满意度间接地起作用。结论:研究结果强调了区分不同类型的社会互动以及考虑其独特的空间和功能驱动因素的重要性。城市规划和公共卫生工作应考虑建筑环境的不同方面如何促进社会关系的形成和维持。促进支持多种形式的社会互动的环境不仅对于增进健康和福祉,而且对于减少孤独的风险至关重要。
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引用次数: 0
Spatial downscaling of multivariate disease risk. 多变量疾病风险的空间降尺度。
IF 3 2区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-01-23 DOI: 10.1186/s12942-025-00450-6
David Payares-Garcia, Frank Osei, Jorge Mateu, Alfred Stein

Downscaling areal health data to a finer resolution is important for understanding the intricate spatial patterns of disease. It helps to identify shared risk factors and to develop targeted public health interventions. This paper introduces Area-to-Area (ATA) and Area-to-Point (ATP) Poisson cokriging for downscaling spatial disease risks from aggregated areal data. The methodology addresses key challenges by incorporating correlation between the diseases, adjusting for population heterogeneity, and the varying shapes and sizes of the spatial entities. Simulation studies demonstrate the superior performance of ATA and ATP Poisson cokriging compared to their univariate counterparts. We achieved lower mean squared prediction errors and better preserved small-scale spatial variations. The methods are applied to COVID-19 and asthma occurrences in Bogota, Colombia. They reveal more detailed hotspots and coldspots and refined estimates of COVID-19 risk by leveraging its correlation with asthma. Our methods offer advantages in multivariate disease mapping by enabling more accurate risk assessment, improved small-area estimation, and enhanced understanding of spatial disease patterns. Their ability to downscale risks for multiple diseases simultaneously provides valuable insights for targeted public health interventions and resource allocation.

将区域健康数据缩小到更精细的分辨率对于理解复杂的疾病空间模式非常重要。它有助于确定共同的风险因素,并制定有针对性的公共卫生干预措施。本文介绍了区域到区域(ATA)和区域到点(ATP)泊松共克里格法,用于从汇总的区域数据降尺度空间疾病风险。该方法通过纳入疾病之间的相关性,调整人口异质性以及空间实体的不同形状和大小来解决关键挑战。仿真研究表明,与单变量泊松共克里格相比,ATA和ATP泊松共克里格具有更优越的性能。我们获得了更低的均方预测误差和更好地保存小尺度空间变化。这些方法应用于哥伦比亚波哥大的COVID-19和哮喘病例。他们通过利用COVID-19与哮喘的相关性,揭示了更详细的热点和冷点,并改进了对COVID-19风险的估计。我们的方法通过更准确的风险评估、改进的小区域估计和增强对空间疾病模式的理解,在多变量疾病制图中具有优势。它们同时降低多种疾病风险的能力为有针对性的公共卫生干预和资源分配提供了宝贵的见解。
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引用次数: 0
Merging geographic regions for the analysis of the cardiological rehabilitation care system in Hungary. 合并地理区域对匈牙利心脏病康复护理系统的分析。
IF 3 2区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-01-14 DOI: 10.1186/s12942-025-00444-4
Marcell Erdős, István Vassányi, Attila Nemes, István Kósa

Background: Identifying spatial patterns or anomalies in medical care related administrative data is a valuable asset to plan the care system. However, the applicability of any results depends on the statistical robustness and spatial resolution of the analysis.

Methods: This study proposes a new method for designing the spatial units for a country-wide analysis, based on the iterative merging of the postal code areas. The method aims to find a trade-off between fine spatial resolution and districts with a statistically relevant number of episodes, also considering the homogeneity of the districts. The method is applied for the spatial analysis of the cardiological rehabilitation care system in Hungary over an 8-year-long period, with the cardiological rehabilitation rate (RR) after acute cardiac events as the dependent variable. We consider two cardiological episode types and perform two separate analyses throughout the study. A voting scheme is used to define the de facto service areas of the dominant providers. Homogeneous spatial clusters with high and low RR values are compared to the boundaries of the service areas using spatial correlation.

Results: The proposed merging method can provide a significantly finer resolution than a simple spatial approach, and the border zones become thinner and clearer between contiguous de facto dominant providers. The spatial analysis found strong clustering with a global Moran I index of 0.80 and 0.85, respectively, and very large regional differences, especially in rural areas of the country, which is consistent with inequities in access or referral pathways. The boundaries of rehabilitation rate anomalies generally match with the dominant service areas of the dominant providers, suggesting that the differences are linked with the anomalies in the professional practice of the providers.

Conclusions: The proposed method proved a useful tool for the spatial analysis of the cardiological rehabilitation network. The method is not specific to the local culture, and it is directly applicable in any other healthcare domain with several service providers and for which population-level, geographically referenced data is available. More research using more elaborate data sources would be needed to understand the root causes of the anomalies detected in the study.

Trial registration: Retrospectively registered.

背景:识别医疗保健相关行政数据的空间模式或异常是规划医疗保健系统的宝贵资产。然而,任何结果的适用性取决于分析的统计稳健性和空间分辨率。方法:提出了一种基于邮政编码区域迭代合并的全国分析空间单元设计新方法。该方法的目的是在精细空间分辨率和具有统计相关事件数的地区之间找到一种权衡,同时考虑到地区的同质性。该方法应用于匈牙利心脏康复护理系统的空间分析,为期8年,急性心脏事件后的心脏康复率(RR)为因变量。我们考虑了两种心脏病发作类型,并在整个研究中进行了两种独立的分析。投票方案用于定义占主导地位的提供商的实际服务区域。利用空间相关性对高、低RR值的同质空间集群与服务区边界进行了比较。结果:所提出的合并方法可以提供比简单的空间方法更精细的分辨率,并且相邻的事实上的主导提供者之间的边界区域变得更薄和更清晰。空间分析发现,全球Moran I指数分别为0.80和0.85,具有很强的聚类性,区域差异非常大,特别是在该国的农村地区,这与获取或转诊途径的不平等一致。康复率异常边界与优势提供者的优势服务领域基本吻合,表明差异与服务提供者的专业实践异常有关。结论:该方法为心脏康复网络的空间分析提供了一种有用的工具。该方法并不特定于当地文化,它直接适用于具有多个服务提供商的任何其他医疗保健领域,并且可以获得人口水平的地理参考数据。需要使用更复杂的数据源进行更多的研究,以了解研究中发现的异常的根本原因。试验注册:回顾性注册。
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引用次数: 0
Temporal-spatial distribution characteristics and associated socioeconomic factors of medical expenditures for rural patients with chronic kidney disease in Fujian Province, Southeast China. 福建省农村慢性肾病患者医疗费用时空分布特征及相关社会经济因素分析
IF 3 2区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-01-03 DOI: 10.1186/s12942-025-00449-z
Rong Fu, Na Wang, Zhenhao Yuan, Yongyi Lin, Shuqing He, Qihui Yang, Zhijian Hu

Background: Chronic kidney disease (CKD) had become one of the increasingly serious public health problems in the world. This study aimed to explore the temporal-spatial distribution characteristics and associated socioeconomic factors of medical expenditures for rural patients with CKD in Fujian province from 2007 to 2016.

Methods: The medical expenditures information of patients with CKD was abstracted from the database of New Rural Cooperative Medical Scheme. Geographically and temporally weighted regression model was used to analyze the associations between per capita annual medical expenditures and six socioeconomic factors at the county level.

Results: The number of rural patients with CKD who visited in medical institutions increased from 3,099 in 2007 to 19,803 in 2016. The total and per capita medical expenditures of rural patients with CKD increased to 545.4 million yuan and 27,539.7 yuan in 2016, respectively. The ratio of per capita out-of-pocket expenses to per capita disposable income decreased from 108.5% in 2007 to 63.2% in 2016. The top 10% of patients with the highest total medical expenditures account for 31.2% ~ 52.5% of total medical expenditures from 2007 to 2016. The counties with high per capita annual medical expenditures mainly concentrated in the southern region and Longyan city. In which, the per capita annual medical expenditures were negatively associated with the percentage of female patients and number of health technicians per 10,000 persons, and positively associated with the percentage of patients who aged ≥ 60 years, percentage of patients whose length of stay > 10 days, per capita annual disposable income and number of beds per 10,000 persons.

Conclusions: The out-of-pocket ratio of rural patients with CKD decreased, but suffering from CKD was still catastrophic. The distribution of medical expenditures in rural residents was uneven and there was temporal-spatial heterogeneity in the associations between per capita annual medical expenditures and socioeconomic factors. It is necessary to improve the awareness and health literacy of residents, systematically carry out CKD screening program in high-risk populations, incorporate CKD into the National Basic Public Health Service Program and increase the number of health technicians which could effectively delay the disease progression and reduce medical expenses.

背景:慢性肾脏疾病(CKD)已成为世界上日益严重的公共卫生问题之一。本研究旨在探讨福建省2007 - 2016年农村CKD患者医疗费用的时空分布特征及相关社会经济因素。方法:从新型农村合作医疗数据库中提取慢性肾病患者的医疗费用信息。采用地理和时间加权回归模型分析了县级人均年医疗费用与6个社会经济因素的关系。结果:农村CKD患者到医疗机构就诊的人数从2007年的3099人增加到2016年的19803人。2016年农村慢性肾病患者总医疗费用和人均医疗费用分别增加到5.454亿元和27539.7元。人均自付费用占人均可支配收入的比例从2007年的108.5%下降到2016年的63.2%。2007 - 2016年总医疗费用最高的前10%患者占总医疗费用的31.2% ~ 52.5%。人均年医疗费用高的县主要集中在南部地区和龙岩市。其中,人均年医疗支出与女性患者比例、每万人卫生技术人员数量呈负相关,与年龄≥60岁患者比例、住院天数≥10天患者比例、人均年可支配收入、每万人床位数呈正相关。结论:农村CKD患者自费比例有所下降,但CKD仍是灾难性的。农村居民年人均医疗支出与社会经济因素的关联存在时空异质性,且医疗支出分布不均衡。需要提高居民的健康意识和健康素养,系统开展CKD高危人群筛查项目,将CKD纳入国家基本公共卫生服务计划,增加卫生技术人员,有效延缓疾病进展,降低医疗费用。
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引用次数: 0
Mapping the COVID-19 pandemic in Burkina Faso: spatial patterns, socioeconomic factors, and public health implications. 绘制布基纳法索COVID-19大流行地图:空间格局、社会经济因素和公共卫生影响
IF 3 2区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-01-03 DOI: 10.1186/s12942-025-00447-1
Abdoul Azize Millogo, Aboubacar Karabinta, Emmanuel Kiendrebeogo, Bry Sylla, Abdoulaye Diabate, Lassane Yameogo

The first case of COVID-19 in Burkina Faso was reported in March 2020. As of June 8, 2025, Burkina Faso reported 22,114 confirmed cases and 400 deaths. However, few studies have investigated the spatiotemporal dynamics of pandemics within the national boundaries. This study provides a retrospective spatial analysis of COVID-19 transmission in Burkina Faso and identifies the key geographic drivers. Case statistics from March 2020 to December 2021 were sourced from the Directorate of Health Information Systems of the Ministry of Health. Covariates were identified through a literature review and retrieved from local and online resources. Spatial and temporal patterns were analyzed using ArcGIS Pro® 3.4.3. Hotspots and directional trends were mapped using Getis-Ord Gi* statistics and standard deviation ellipses, and district-level spatial associations were evaluated. Multiscale Geographically Weighted Regression (MGWR) was used to model the relationships between disease incidence and geographic features. Five major transmission phases were observed. Specifically, 20 Health Districts were affected between March and April 2020, 38 in September 2020, 62 in April 2021, and 67 in December 2021. Initially, a single hotspot centered in Ouagadougou was identified. A second hotspot emerged in Bobo Dioulasso in September 2020, considerable heterogeneity in case distribution was noted across the districts. The MGWR results highlight population density, poverty rate, relative wealth index, and distance to testing centers as the main spatial drivers, collectively explaining 70% of the variance in incidence. The findings revealed a fast-evolving outbreak with significant spatial variation, revealed the need for adaptive, geography-informed responses. This multiphase framework can inform real-time risk forecasting and improve epidemic preparednessin in low-resource settings.

布基纳法索于2020年3月报告了第一例COVID-19病例。截至2025年6月8日,布基纳法索报告了22114例确诊病例和400例死亡。然而,很少有研究调查了国界内流行病的时空动态。本研究对COVID-19在布基纳法索的传播进行了回顾性空间分析,并确定了关键的地理驱动因素。2020年3月至2021年12月的病例统计数据来自卫生部卫生信息系统司。通过文献综述确定协变量,并从本地和在线资源中检索。使用ArcGIS Pro®3.4.3分析时空格局。利用Getis-Ord Gi*统计量和标准差椭圆对热点和方向趋势进行了映射,并对区级空间关联进行了评价。采用多尺度地理加权回归(MGWR)对疾病发病率与地理特征之间的关系进行建模。观察到五个主要的传播阶段。具体而言,2020年3月至4月期间有20个卫生区受到影响,2020年9月有38个,2021年4月有62个,2021年12月有67个。最初,确定了以瓦加杜古为中心的单一热点。第二个热点于2020年9月在博博迪乌拉索出现,各地区的病例分布存在相当大的异质性。MGWR结果强调,人口密度、贫困率、相对财富指数和到测试中心的距离是主要的空间驱动因素,共同解释了70%的发病率差异。调查结果显示,疫情发展迅速,具有显著的空间差异,表明需要采取适应性的、了解地理情况的应对措施。这一多阶段框架可以为实时风险预测提供信息,并改善资源匮乏地区的流行病防范工作。
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引用次数: 0
Spatial distribution and the imbalance between supply and demand: an analysis of the geographical characteristics and regional differences of elderly care institutions in China. 空间分布与供需失衡:中国养老机构的地理特征与区域差异分析。
IF 3 2区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-31 DOI: 10.1186/s12942-025-00445-3
Kexin Zhang, Tingzhi Miao, Tiangui Wang, Huiqing Han, Jiaoting Peng, Yan Ji

Against the backdrop of China's continuously intensifying population aging, the spatially balanced distribution of elderly care institutions (ECIs) has emerged as a critical issue for alleviating elderly care pressure and advancing social equity. Utilizing nationally registered ECI data, this study integrates ArcGIS spatial analysis with an Optimal-Parameter Geographical Detector (OPGD) approach to systematically investigate the spatial heterogeneity, supply-demand imbalance patterns, and underlying formation mechanisms of ECIs in China at the provincial level. A key finding is the pronounced spatial and structural imbalance between supply and demand. Kernel density estimation reveals a multi-level clustering structure centered on Shanghai and Chongqing, while the consistency coefficient identifies distinct mismatch patterns: regions such as Xinjiang and Northeast China experience "supply exceeding demand," whereas economically dynamic areas like the Pearl River Delta face "supply falling behind demand." Spatially, ECIs overall follow a "dense southeast-sparse northwest" pattern closely aligned with the "Hu Huanyong Line," with six provinces including Henan and Sichuan accounting for 34.1% of institutions, compared to only 1.6% in four western provinces/regions and Hainan. Furthermore, OPGD analysis identifies the permanent population size and number of hospital beds as the dominant factors influencing the spatial layout of ECIs. Their interaction with public transportation accessibility and fiscal expenditure significantly enhances explanatory power, highlighting the crucial role of medical-care integration and government investment in resource allocation. This study provides a scientific basis for optimizing the spatial allocation of elderly care resources and promoting coordinated regional development in China.

在中国人口老龄化持续加剧的背景下,养老机构的空间均衡分布已成为缓解养老压力、促进社会公平的关键问题。本研究利用全国ECI数据,结合ArcGIS空间分析和最优参数地理探测器(OPGD)方法,系统研究了中国省级ECI的空间异质性、供需失衡格局及其形成机制。一个关键的发现是供需之间明显的空间和结构失衡。核密度估计揭示了以上海和重庆为中心的多层次集群结构,而一致性系数则确定了明显的错配模式:新疆和东北等地区经历了“供过于求”,而珠江三角洲等经济活跃地区则面临“供过于求”。从空间上看,高校高校总体呈现“东南密集-西北稀疏”的格局,与“胡焕永线”密切相关,河南、四川等6省高校高校占比34.1%,而西部4省区和海南高校高校高校占比仅为1.6%。此外,OPGD分析发现常住人口规模和床位数是影响综合医院空间布局的主要因素。它们与公共交通可达性和财政支出的交互作用显著增强了解释力,突出了医疗一体化和政府投资在资源配置中的关键作用。该研究为优化养老资源空间配置,促进中国区域协调发展提供了科学依据。
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引用次数: 0
Understanding socioeconomic inequalities in COVID-19 vaccination: controlling endogenous selection in Cali, Colombia. 了解COVID-19疫苗接种中的社会经济不平等:控制哥伦比亚卡利的内生选择
IF 3 2区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-28 DOI: 10.1186/s12942-025-00448-0
Manuel A Moreno, Francisco J Rodríguez-Cortés, Marc Saez, Maria A Barceló

Background: The COVID-19 pandemic displayed notable disparities in infection and mortality rates across populations, yet socioeconomic factors remain underexplored in many analyses. This study leverages an individual-level dataset from Cali, Colombia, detailing COVID-19 cases, vaccination histories, and mortality outcomes, to examine spatiotemporal vaccination patterns and their effects on mortality.

Methods: Using a Bayesian two-part model with generalized linear mixed models, the analysis accounts for endogenous selection, individual heterogeneity, and spatial-temporal dependencies.

Results: The findings highlight significant socioeconomic inequalities in vaccination coverage: individuals from higher socioeconomic strata were more likely to receive full vaccination regimens and booster doses, while those from lower strata faced reduced vaccination coverage and elevated mortality risks. Employment, socioeconomic status, and ethnicity emerged as key predictors of vaccination propensity and mortality, disproportionately disadvantaging vulnerable groups.

Conclusions: These results stress the need for equitable vaccine distribution and targeted interventions to address disparities and enhance public health outcomes.

背景:2019冠状病毒病大流行在不同人群的感染率和死亡率方面存在显著差异,但许多分析仍未充分探讨社会经济因素。本研究利用来自哥伦比亚卡利的个人层面数据集,详细介绍了COVID-19病例、疫苗接种史和死亡率结果,以研究时空疫苗接种模式及其对死亡率的影响。方法:采用贝叶斯两部分模型和广义线性混合模型,分析了内生选择、个体异质性和时空依赖性。结果:研究结果突出了疫苗接种覆盖率的显著社会经济不平等:来自较高社会经济阶层的个体更有可能接受完整的疫苗接种方案和加强剂量,而来自较低社会经济阶层的个体则面临疫苗接种覆盖率降低和死亡风险升高的问题。就业、社会经济地位和种族成为疫苗接种倾向和死亡率的关键预测因素,使弱势群体处于不成比例的不利地位。结论:这些结果强调需要公平的疫苗分配和有针对性的干预措施,以解决差距和提高公共卫生结果。
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引用次数: 0
Association of socio-economic and clinical factors with influenza vaccination uptake in high-risk individuals: an Italian retrospective cohort study, 2019-2023. 社会经济和临床因素与高危人群流感疫苗接种的关联:2019-2023年意大利回顾性队列研究
IF 3 2区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-27 DOI: 10.1186/s12942-025-00446-2
Francesca Fortunato, Roberto Lillini, Martina Bertoldi, Alessandro Borgini, Georgia Casanova, Angelo Campanozzi, Rosa Prato, Domenico Martinelli

Background: Influenza can cause serious complications in individuals with chronic diseases. Although vaccination is strongly recommended for the high-risk population, uptake remains suboptimal. This retrospective cohort study assessed the relationship between demographic, clinical, and socio-economic (SE) factors and influenza vaccination uptake among high-risk patients in the Apulia region over four influenza seasons (2019-2023).

Methods: Data on comorbidities, vaccination history, and demographics were extracted from the User Fee Exemption Registry, the Immunization Information System, and the Total Population Register, respectively. Each geocoded case was linked to the Italian National Deprivation Index to determine SE status at the census tract level. Descriptive statistics, logistic regression, and multilevel mixed general linear models were used to analyze factors associated with vaccination uptake.

Results: Vaccination coverage among people with longstanding illnesses was 35.5% in 2019-2020, peaked at 44.7% in 2020-2021, and declined thereafter (42.9% in 2021 - 2022; 40.1% in 2022 - 2023). Higher uptake was associated with female sex, older age, and a greater number of comorbidities. SE deprivation was inversely associated with vaccination uptake. Individuals with chronic renal/adrenal insufficiency, cardiovascular, or neoplastic diseases had the highest uptake. The data also suggest a potential link between marital status and the likelihood of vaccination.

Conclusions: Demographic, SE, and clinical factors may play a significant role in influenza vaccination uptake. Public health strategies should consider these determinants to improve coverage and reduce health inequalities.

背景:流感可引起慢性疾病患者的严重并发症。尽管强烈建议高危人群接种疫苗,但接种率仍不理想。本回顾性队列研究评估了Apulia地区四个流感季节(2019-2023)高危患者中人口统计学、临床和社会经济(SE)因素与流感疫苗接种之间的关系。方法:分别从用户免费登记、免疫信息系统和总人口登记中提取合并症、疫苗接种史和人口统计数据。每个地理编码的病例都与意大利国家贫困指数相关联,以确定人口普查区的贫困状况。使用描述性统计、逻辑回归和多水平混合一般线性模型分析与疫苗接种相关的因素。结果:长期疾病人群的疫苗接种率在2019-2020年为35.5%,在2020-2021年达到44.7%的峰值,此后下降(2021 - 2022年为42.9%,2022 - 2023年为40.1%)。较高的摄取与女性、年龄较大和更多的合并症有关。SE剥夺与疫苗接种呈负相关。慢性肾/肾上腺功能不全、心血管疾病或肿瘤疾病患者的摄取最高。数据还表明,婚姻状况与接种疫苗的可能性之间存在潜在联系。结论:人口统计学、SE和临床因素可能在流感疫苗接种中发挥重要作用。公共卫生战略应考虑到这些决定因素,以提高覆盖面并减少卫生不平等现象。
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引用次数: 0
Multiscale geographically weighted modeling of tuberculosis incidence in China: integrating geographic perspectives into epidemiological analysis. 中国结核病发病率的多尺度地理加权模型:将地理视角整合到流行病学分析中。
IF 3 2区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-24 DOI: 10.1186/s12942-025-00435-5
Zihao Wang, Jianchen Zhang

Background: Tuberculosis (TB) is a major global health problem, and the pathogenesis of TB is determined by multiple variables. The complicated relationship between geographic determinants and incidence rates is poorly understood, and multicollinearity and spatial heterogeneity were not considered when exploring this relationship.

Methods: In this study, the factors influencing the incidence of TB in China were investigated, considering spatial heterogeneity, to develop a multidimensional TB indicator system that incorporates geographic factors. A comprehensive linear-nonlinear two-stage feature screening model was developed to identify key factors contributing to TB. The ordinary least squares model was constructed at the national scale using these key indicators to understand the macro-relationships between TB incidence rates and key indicators. A geographically weighted regression (GWR) model was constructed at a provincial scale, and a multiscale geographically weighted regression (MGWR) model was developed to conduct an in-depth comparative analysis of the fitting effects of the GWR and MGWR models on the TB incidence rates. The goal of this study is to investigate the impact of the GWR and MGWR models on TB incidence. The adjustable bandwidth mechanism of the MGWR model was compared with the fixed bandwidth mechanism of the GWR model to determine the best model for geographical analysis of TB incidence.

Results: The MGWR model had the best fit (R2 = 0.942; AICc = 57.060) for TB incidence and provided unique bandwidths for important variables to improve model geographic analysis. The analysis of geographic components using the MGWR model revealed that the fitting coefficients of mean height, topographic relief, and average annual precipitation were spatially heterogeneous.

Conclusion: These results provide the theoretical foundation for developing TB prevention and control measures.

背景:结核病(TB)是全球主要的健康问题,其发病机制由多种因素决定。地理决定因素与发病率之间的复杂关系尚不清楚,在探索这种关系时未考虑多重共线性和空间异质性。方法:在考虑空间异质性的基础上,对中国结核病发病率的影响因素进行研究,构建包含地理因素的多维结核病指标体系。建立了一个综合的线性-非线性两阶段特征筛选模型,以确定导致结核病的关键因素。利用这些关键指标在全国范围内构建普通最小二乘模型,了解结核病发病率与关键指标之间的宏观关系。在省级尺度上构建地理加权回归(GWR)模型,建立多尺度地理加权回归(MGWR)模型,深入对比分析GWR和MGWR模型对结核病发病率的拟合效果。本研究的目的是探讨GWR和MGWR模型对结核病发病率的影响。将MGWR模型的可调带宽机制与GWR模型的固定带宽机制进行比较,确定结核发病率地理分析的最佳模型。结果:MGWR模型对结核病发病率具有最佳拟合(R2 = 0.942; AICc = 57.060),并为重要变量提供了独特的带宽,提高了模型的地理分析水平。基于MGWR模型的地理成分分析表明,平均高度、地形起伏度和年平均降水量的拟合系数具有空间异质性。结论:研究结果为制定结核病防治措施提供了理论依据。
{"title":"Multiscale geographically weighted modeling of tuberculosis incidence in China: integrating geographic perspectives into epidemiological analysis.","authors":"Zihao Wang, Jianchen Zhang","doi":"10.1186/s12942-025-00435-5","DOIUrl":"10.1186/s12942-025-00435-5","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis (TB) is a major global health problem, and the pathogenesis of TB is determined by multiple variables. The complicated relationship between geographic determinants and incidence rates is poorly understood, and multicollinearity and spatial heterogeneity were not considered when exploring this relationship.</p><p><strong>Methods: </strong>In this study, the factors influencing the incidence of TB in China were investigated, considering spatial heterogeneity, to develop a multidimensional TB indicator system that incorporates geographic factors. A comprehensive linear-nonlinear two-stage feature screening model was developed to identify key factors contributing to TB. The ordinary least squares model was constructed at the national scale using these key indicators to understand the macro-relationships between TB incidence rates and key indicators. A geographically weighted regression (GWR) model was constructed at a provincial scale, and a multiscale geographically weighted regression (MGWR) model was developed to conduct an in-depth comparative analysis of the fitting effects of the GWR and MGWR models on the TB incidence rates. The goal of this study is to investigate the impact of the GWR and MGWR models on TB incidence. The adjustable bandwidth mechanism of the MGWR model was compared with the fixed bandwidth mechanism of the GWR model to determine the best model for geographical analysis of TB incidence.</p><p><strong>Results: </strong>The MGWR model had the best fit (R<sup>2</sup> = 0.942; AICc = 57.060) for TB incidence and provided unique bandwidths for important variables to improve model geographic analysis. The analysis of geographic components using the MGWR model revealed that the fitting coefficients of mean height, topographic relief, and average annual precipitation were spatially heterogeneous.</p><p><strong>Conclusion: </strong>These results provide the theoretical foundation for developing TB prevention and control measures.</p>","PeriodicalId":48739,"journal":{"name":"International Journal of Health Geographics","volume":"24 1","pages":"46"},"PeriodicalIF":3.0,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12729106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145829062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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International Journal of Health Geographics
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