Complementary Therapies in Clinical Practice最新文献

{"title":"Auriculotherapy for people with sleep disorders: A systematic review","authors":"Gilmara Holanda da Cunha ,&nbsp;Ane Kelly Lima Ramalho ,&nbsp;Maiara Bezerra Dantas ,&nbsp;Maria Elisa Curado Gomes ,&nbsp;Vanessa Sousa dos Santos ,&nbsp;Ivana Cristina Vieira de Lima Maia ,&nbsp;Carolina Maria de Lima Carvalho ,&nbsp;Wilson Correia de Abreu","doi":"10.1016/j.ctcp.2025.101976","DOIUrl":"10.1016/j.ctcp.2025.101976","url":null,"abstract":"<div><h3>Background</h3><div><em>and purpose</em>: Considering the importance of analyzing the evidence of complementary and alternative medicine practices, this study aimed to evaluate clinical trials on auriculotherapy in people with sleep disorders.</div></div><div><h3>Methods</h3><div>Systematic review carried out in eight databases: Scopus, MEDLINE, LILACS, IBECS, EMBASE, The Cochrane Library, PsycINFO and Web of Science. The recommendations of the Cochrane Handbook for Systematic Reviews of Interventions and of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement were followed. Bias analysis of the studies was carried with the Risk-of-Bias Tool For Randomized Trials (RoB2). The quality of the systematic review was assessed by using AMSTAR 2 (A MeaSurement Tool to Assess Systematic Reviews). The inclusion criteria were randomized clinical trial, without restrictions on language or publication date, using auriculotherapy in people with sleep disorders.</div></div><div><h3>Results</h3><div>A total of 464 articles were identified, and 14 were included in the study. The studies evaluated the efficacy of auriculotherapy in improving sleep quality in older people, perimenopausal and postmenopausal women, breast cancer survivors, college students, people with dependence on heroin and other substances, and veteran soldiers with posttraumatic stress disorder, and in the treatment of insomnia, anxiety and depression in adults. The 14 studies had some risk of bias. The rating of the methodological quality of the review by AMSTAR 2 was considered high.</div></div><div><h3>Conclusion</h3><div>Auriculotherapy had positive effects individually and when combined with conventional treatments for insomnia.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"59 ","pages":"Article 101976"},"PeriodicalIF":2.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trigona honey effect on wound pH and healing in diabetes-related foot ulcers: A case series","authors":"Sukarni Sukarni ,&nbsp;Muhammad Aminuddin ,&nbsp;Mao Kunimitsu ,&nbsp;Kanae Mukai ,&nbsp;Mayumi Okuwa ,&nbsp;Haryanto Haryanto ,&nbsp;Suriadi Jais ,&nbsp;Makoto Oe","doi":"10.1016/j.ctcp.2025.101975","DOIUrl":"10.1016/j.ctcp.2025.101975","url":null,"abstract":"<div><h3>Background</h3><div>Diabetes-related foot ulcers (DFUs) often become chronic due to prolonged inflammation and alkaline wound pH. Trigona honey is a potential therapy due to its low pH and antimicrobial properties. This case series explores pH dynamics and the effect of Trigona honey therapy on healing of DFUs and offers insights into optimizing treatment strategies to improve healing outcomes.</div></div><div><h3>Patient presentation</h3><div>Four patients with DFUs were treated with Trigona honey and followed until healing or 8 weeks. Wound bed pH was measured and wound characteristics were assessed with the DMIST tool at each follow-up visit. In two patients who healed, the inflammatory phase lasted 11 and 6 days, and the wound bed was acidic during most of the proliferative phase. In two patients who did not heal within 8 weeks, the inflammatory phase lasted 27 and 25 days, and the wound bed was alkaline for most of the proliferative phase.</div></div><div><h3>Conclusion</h3><div>Ulcers that did not heal had a longer inflammatory phase and wound bed pH was more alkaline than in ulcers that healed. Although Trigona honey might not directly affect the pH of the wound bed, treatment should be modified if alkaline granulation tissue is observed.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"59 ","pages":"Article 101975"},"PeriodicalIF":2.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Movement behaviours and eating habits in children: a cross-sectional study","authors":"Wurigenmuren ,&nbsp;Shaoying Liu","doi":"10.1016/j.ctcp.2025.101974","DOIUrl":"10.1016/j.ctcp.2025.101974","url":null,"abstract":"<div><h3>Objective</h3><div>It is well-established that adherence to 24-h movement guidelines affects various health outcomes. However, few studies have explored its impacts on eating habits in children comprehensively, with most focusing on small or non-representative samples, and neglecting the combined effects of movement behaviours. Therefore, this study aims to investigate the relationship between adherence to 24-h movement guidelines and eating habits in Chinese children.</div></div><div><h3>Methods</h3><div>School-aged students were included for analysis. Physical activity and screen time were assessed using items from the Health Behaviour in School-aged Children questionnaire (the Chinese version). Sleep duration was assessed using the items from the Pittsburgh Sleep Quality Index (PSQI). Multivariable ordinal logistic regression models were used to explore the relationship between adherence to 24-h movement guidelines and eating habits.</div></div><div><h3>Results</h3><div>Overall, only 1.4 % of children adhered to 24-h movement guidelines. Regression analysis showed that children adhering to one (OR = 1.35, CI: 1.05–1.73) or two recommendations (OR = 1.52, CI = 1.17–1.97) were more inclined to consume fruits compared to those who did not adhere to any recommendations. Those who adhered to two recommendations exhibited reduced likelihoods of consuming soft drinks (OR = 0.62, CI: 0.46–0.81) and junk food (OR = 0.48, CI: 0.35–0.66), whereas adherence to one recommendation displayed a diminished likelihood of consuming junk food.</div></div><div><h3>Conclusion</h3><div>Although no significant association between adherence to all 24-hour movement guidelines and better eating habits was discerned, it was worth noting that adherence to both the recommendations for moderate-to-vigorous physical activity and screen time may have positive effects of improving eating habits.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"60 ","pages":"Article 101974"},"PeriodicalIF":2.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the impact of lavender aromatherapy and music therapy on reducing stress, anxiety, and depression in female nurses during the COVID-19 pandemic","authors":"Hao-Jan Yang ,&nbsp;Miao Wen Li ,&nbsp;Tzu-Chun Chen","doi":"10.1016/j.ctcp.2025.101973","DOIUrl":"10.1016/j.ctcp.2025.101973","url":null,"abstract":"<div><h3>Purpose</h3><div>Nurses often experience high levels of physical and psychological stress due to frequent exposure to emergency and critical situations, which can adversely affect their professional performance. This study aimed to evaluate and compare the short- and long-term impacts of combining aromatherapy with music therapy versus using aromatherapy alone on the physical and psychological well-being of nurses during the COVID-19 pandemic.</div></div><div><h3>Method</h3><div>This study employed a quasi-experimental design without non-intervention control group and recruited 60 nurses from a regional teaching hospital in central Taiwan between February and November 2023. Participants were randomly assigned to two groups: one group received aromatherapy, and the other group received a combination of aromatherapy and music therapy. The aromatherapy intervention involved inhaling gas infused with lavender essential oil. The intervention was conducted once a week during the lunch break for 20 min over a six-week period. Physiological and psychological indicators were compared before and after the intervention. Physiological indicators included systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse rate (PR). Psychological indicators included scores on the Nursing Stress Scale (NSS), Beck Anxiety Inventory (BAI), and Beck Depression Inventory (BDI), which measured stress, anxiety, and depression, respectively.</div></div><div><h3>Results</h3><div>Overall, after each aromatherapy intervention, the physiological and psychological measures of the nurses in both groups showed significant reductions (p &lt; 0.05) based on paired t-tests. After six measurements, a one-way repeated measures ANOVA was conducted, revealing that most physiological and psychological measures of the nurses in the aromatherapy-only group were significantly reduced (p &lt; 0.05), although no significant differences were found for diastolic blood pressure and pulse rate. In the group receiving aromatherapy combined with music therapy, all physiological and psychological measures showed significant reductions in repeated measures tests (p &lt; 0.05). These results suggest that aromatherapy combined with music therapy not only improved physical and psychological symptoms immediately but also had lasting effects for at least six weeks.</div></div><div><h3>Conclusions</h3><div>This study found that aromatherapy effectively reduced the physical and psychological stress of nurses, with even greater benefits when combined with music therapy. This approach not only provided immediate effects but also were associated with lasting benefits for an extended duration.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"59 ","pages":"Article 101973"},"PeriodicalIF":2.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can mat Pilates improve quality of life components in breast cancer survivors receiving hormone therapy? A randomized controlled trial","authors":"Josefina Bertoli ,&nbsp;Antonio Cleilson Nobre Bandeira ,&nbsp;Cíntia de la Rocha Freitas ,&nbsp;Ismael Forte Freitas Júnior","doi":"10.1016/j.ctcp.2025.101972","DOIUrl":"10.1016/j.ctcp.2025.101972","url":null,"abstract":"<div><h3>Background</h3><div>Short and long-term breast cancer treatment side-effects allied with the increase of sedentary behavior, affect quality of life (QoL). Nonetheless, regular physical exercise appears to ameliorate breast cancer survivor (BCS) QoL components.</div></div><div><h3>Purpose</h3><div>to analyze the effect of 24 weeks of mat Pilates (3 times/week, 60 min session) in BCS receiving hormone therapy on QoL components.</div></div><div><h3>Materials and methods</h3><div>43 participants were randomized according to hormone therapy (Tamoxifen (TMX) or Aromatase Inhibitors (AIs)) in the Pilates group (PG) and control group (CG). The QoL data was collected through SF-36, EORT-30, and 23 questionnaires. The evaluations occurred at baseline (T1), at week 12 (T2), and week 24 (T3) of the intervention. The generalized estimating equations model was used with the Bonferroni post hoc test (p &lt; 0.05).</div></div><div><h3>Results</h3><div>The SF-36 showed that CG improved physical limitations at T2 compared to T1 (p = 0.032). The Pilates group enhanced emotional aspects compared to CG at T3 (0.009), social aspects at T3 compared to its baseline (p = 0.023), and mental health at T3 compared to CG (p = 0.026). The specific breast cancer questionnaires (EORT-30 and 23) did not show differences throughout the intervention.</div></div><div><h3>Conclusions</h3><div>Only the SF-36 showed enhancement for PG QoL components. The EORT-30 and 23 domains are directly related to the side effect treatments, which could influence the outcomes.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"59 ","pages":"Article 101972"},"PeriodicalIF":2.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in the prescription of benzodiazepines and related drugs at month 12 after E2R hypnotherapy in previously treated patients: A descriptive study","authors":"B. Bastian ,&nbsp;F. Martineau ,&nbsp;M. Esvan ,&nbsp;S.L. Mamoune ,&nbsp;E. Mener","doi":"10.1016/j.ctcp.2025.101971","DOIUrl":"10.1016/j.ctcp.2025.101971","url":null,"abstract":"<div><h3>Background and purpose</h3><div>In France, benzodiazepines are widely prescribed and consumed for anxiety and sleep disorders. E2R (Emotion, Regression, Repair) hypnotherapy could be an alternative non-pharmacological method to reduce their long-term use. The aim of this study was to estimate indirectly the effect of E2R hypnosis on the withdrawal rate at month 12 post-hypnotherapy in patients on long-term treatment (&gt;3 months) with benzodiazepines or related drugs.</div></div><div><h3>Materials and methods</h3><div>Retrospective observational study using data on 73 patients treated with E2R hypnotherapy for anxiety, depression or sleep disorders extracted from the patient databases of some French general practitioners trained in E2R hypnosis. Prescription of benzodiazepines or related drugs was analyzed at inclusion and at month 12 after E2R hypnotherapy.</div></div><div><h3>Results</h3><div>At month 12, 79.5 % had reduced or stopped their consumption (mean reduction of 55 %): 57.5 % of patients had completely stopped taking benzodiazepines or related drugs (95 % CI: 45.4 %–69.0 %) and 21.9 % were using them occasionally, based on the general practitioners' prescriptions. The percentage of patients with antidepressant prescriptions also decreased from 49.3 % to 31.5 % and 44.4 % of initial users stopped taking antidepressants. No factor associated with drug withdrawal was identified.</div></div><div><h3>Conclusion</h3><div>This observational study suggests that E2R hypnotherapy might be a promising and rapid approach for reducing or discontinuing benzodiazepines or related drugs, with results similar to those obtained with other non-pharmacological interventions. Controlled trials are needed to confirm its efficacy.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"59 ","pages":"Article 101971"},"PeriodicalIF":2.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilot of an animal-assisted activity program to support intergenerational and intercultural community connections to reduce loneliness and social isolation","authors":"Em Bould ,&nbsp;Natasha K. Brusco ,&nbsp;Libby Callaway","doi":"10.1016/j.ctcp.2025.101970","DOIUrl":"10.1016/j.ctcp.2025.101970","url":null,"abstract":"<div><h3>Background and purpose</h3><div>The COVID-19 pandemic challenged social support systems leading to loneliness and social isolation, particularly for older adults and international university students. This study explored the potential of using a shared interest in pets to support intergenerational and intercultural social connections, with a hypothesis that such interactions could enhance health-related quality of life and wellbeing and reduce feelings of loneliness.</div></div><div><h3>Methods</h3><div>The study adopted an action research approach to co-design and pilot an Animal-Assisted Activity (AAA) group intervention (called the ‘Pets and People program’) across two aged care facilities in Melbourne, Australia. The 18-week program was designed to facilitate social connections through the presence of live or robotic pets, and/or animal-assisted activities. The program was evaluated using mixed methods.</div></div><div><h3>Results</h3><div>Thirty older adults and 11 international students participated in the program. Six older adults, 10 international university students and three senior management staff participated in the evaluation. Both the older adult and student groups experienced a significant decrease in feelings of loneliness and a significant and clinically meaningful increase in the EQ-5D-5L utility index after program completion. The cost of implementation was $237 per person who participated in 10 weeks or more of the 18-week program. The explorative cost-utility analysis indicated a cost of $4,017 per quality adjusted life year gained, which is well below the threshold for the Australian Government's health related expenditure.</div></div><div><h3>Conclusions</h3><div>The Pets and People program holds potential to be replicated and scaled in aged care settings both in Australia and internationally.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"59 ","pages":"Article 101970"},"PeriodicalIF":2.2,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical manipulation accelerates recovery and further correction of cervical alignment in mechanical neck pain (MNP) patients with neck exercise: A randomized controlled trial","authors":"Ke Wu ,&nbsp;Rongrong Deng ,&nbsp;Xu Zhao ,&nbsp;Zihan Wang ,&nbsp;Qingyuan Ru ,&nbsp;Xin Chen ,&nbsp;Botao Zhang ,&nbsp;Liping Chen ,&nbsp;Ran Kang","doi":"10.1016/j.ctcp.2025.101969","DOIUrl":"10.1016/j.ctcp.2025.101969","url":null,"abstract":"<div><h3>Background</h3><div>Mechanical neck pain (MNP) is often associated with changes in cervical sagittal alignment, causing pain and functional limitations.</div></div><div><h3>Objective</h3><div>This study evaluated the additional effects of cervical manipulation in patients with MNP undergoing neck retraction exercise.</div></div><div><h3>Methods</h3><div>Patients with MNP were randomly assigned to either the cervical manipulation plus neck retraction exercise group (CM + NRE) or the neck retraction exercise group (NRE). Both groups completed their respective regimens over an 8-week period. Primary outcomes include visual analogue scale (VAS) and cervical range of motion (CROM). Secondary outcomes include neck disability index (NDI), neck muscle strength, and cervical sagittal alignment (relative rotation angles [RRA]; absolute rotation angles [C_2-7ARA]; cervical sagittal vertical axis [c_2-7SVA]). The statistical analysis applied intention-to-treat (ITT) and per-protocol (PP) analyses.</div></div><div><h3>Results</h3><div>In the ITT analysis, the CM + NRE group demonstrated more pronounced changes in VAS and CROM after the first treatment (VAS: d = 1.83, P = 0.001; CROM: d = 1.92, P = 0.001), at 4 weeks (VAS: d = 0.98, P = 0.001; CROM: d = 1.05, P = 0.001), 8 weeks (VAS: d = 1.05, P = 0.001; CROM: d = 0.93, P = 0.001), and at a 4-week follow-up (VAS: d = 1.16, P = 0.001; CROM: d = 0.91, P = 0.001). In the assessments of NDI, RRA, and C_2-7ARA, the CM + NRE group showed significantly greater changes compared to the NRE group (p &lt; 0.05). These results were consistent with the PP analysis.</div></div><div><h3>Conclusion</h3><div>Cervical manipulation enhances the effectiveness of neck retraction exercise, which promotes rapid recovery from neck pain and stiffness and further facilitates the correction of cervical sagittal alignment in patients with MNP.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"59 ","pages":"Article 101969"},"PeriodicalIF":2.2,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the impact of various exercise modalities on old adults with Alzheimer's disease: A Bayesian network meta-analysis","authors":"Fengting Hu ,&nbsp;Jin Peng ,&nbsp;Weiran Wang ,&nbsp;Lin Shen ,&nbsp;Mingyuan Jia","doi":"10.1016/j.ctcp.2025.101968","DOIUrl":"10.1016/j.ctcp.2025.101968","url":null,"abstract":"<div><h3>Background and purpose</h3><div>The global prevalence of Alzheimer's disease (AD) in the elderly is rising, and exercise is increasingly used as a non-pharmacological intervention. However, the most effective exercise modality for improving quality of life, alleviating depression, and reducing neuropsychiatric symptoms in AD patients remains unclear. This study aims to identify the optimal exercise modality for addressing these symptoms through a network meta-analysis.</div></div><div><h3>Methods</h3><div>As of November 2024, we conducted a comprehensive search across six databases: PubMed, Embase, Web of Science, the Cochrane Central Register of Controlled Trials, CINAHL, and PsycINFO. This study included only randomized controlled trials (RCTs), with study durations ranging from 2 to 24 weeks, primarily set in clinical or community environments. Following the PRISMA-NMA guidelines, we conducted statistical analysis using the \"gemtc\" package in R and assessed evidence quality via the CINeMA online platform.</div></div><div><h3>Results</h3><div>A network meta-analysis of 29 RCTs with 1507 participants showed that for global cognition, Aerobic exercise (AE) [MD = 2.83, 95 % CI (0.66, 4.85)] ranked first with 79.5 % probability; for quality of daily life, Resistance Training (RT) [SMD = 0.96, 95 % CI (−0.14, 2.07)] ranked first with 83.7 %; for depression, Physical Activity Program (PAP) [SMD = −3.76, 95 % CI (−7.06, −0.47)] ranked first with 96.0 %; and for neuropsychiatric inventory outcomes, AE [SMD = −2.35, 95 % CI (−5.95, 1.06)] ranked first with 71.1 %.</div></div><div><h3>Conclusions</h3><div>Based on the findings from retrospective studies, aerobic exercise may be an effective intervention for improving overall cognition and quality of life in individuals aged 60 and above with Alzheimer's disease.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"59 ","pages":"Article 101968"},"PeriodicalIF":2.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Zataria multiflora mouthwash and chlorhexidine compared to chlorhexidine alone on the incidence of ventilator-associated pneumonia in patients admitted to intensive care units","authors":"Seyed Afshin Shorofi ,&nbsp;Samira Golchin-Mehr ,&nbsp;Seyed Nouraddin Mousavinasab ,&nbsp;Paul Arbon ,&nbsp;Majid Saeedi ,&nbsp;Mohammad Ali Ebrahimzadeh","doi":"10.1016/j.ctcp.2025.101966","DOIUrl":"10.1016/j.ctcp.2025.101966","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Ventilator-associated pneumonia (VAP) is the most prevalent nosocomial infection in intensive care units (ICUs). To prevent VAP, several strategies are employed, including oral care with mouthwashes. This study sought to compare the effects of <em>Zataria multiflora</em> essential oil mouthwash combined with chlorhexidine (ZM + CHG) against chlorhexidine (CHG) alone in reducing the incidence of VAP among ICU patients.</div></div><div><h3>Materials and methods</h3><div>This study is a single-blind clinical trial involving 120 mechanically ventilated ICU patients. They were randomly assigned into two groups. One group received <em>Zataria multiflora</em> 0.2 % mouthwash and chlorhexidine gluconate 0.2 % mouthwash (ZM + CHG group), while the control group received chlorhexidine gluconate 0.2 % mouthwash (CHG group), both administered twice daily for five days. Clinical pulmonary infection, oral health, and oral mucosal-plaque condition were assessed using the clinical pulmonary infection score (CPIS), Beck oral assessment scale (BOAS), and mucosal-plaque score (MPS), respectively.</div></div><div><h3>Results</h3><div>Both ZM + CHG and CHG were effective in reducing the incidence of VAP, with ZM + CHG demonstrating superior effectiveness (p &lt; 0.05). Moreover, ZM + CHG led to a significant improvement in oral and dental health scores and oral mucosal plaque condition compared to CHG (p &lt; 0.05). This study found no significant complications from using either mouthwash, although the follow-up period was relatively short.</div></div><div><h3>Conclusion</h3><div>ZM + CHG reduced the incidence of VAP in ICU patients more effectively than CHG. It also improved oral health and mucosal-plaque condition in mechanically ventilated patients. Thus, ZM + CHG could serve as an alternative to CHG in ICU patients under mechanical ventilation. However, additional studies are needed to confirm its impact on VAP incidence.</div></div>","PeriodicalId":48752,"journal":{"name":"Complementary Therapies in Clinical Practice","volume":"60 ","pages":"Article 101966"},"PeriodicalIF":2.2,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}