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Plasma S100A8 and S100A9 Are Strong Prognostic Factors for Hepatitis B Virus-Related Acute-on-Chronic Liver Failure. 血浆S100A8和S100A9是乙型肝炎病毒相关急慢性肝衰竭的重要预后因素
IF 2.7 4区 医学 Q2 Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/6164611
Yao Zhang, Xueyun Zhang, Jiajia Han, Yifei Guo, Jingjing He, Feifei Yang, Richeng Mao, Yuxian Huang, Jiming Zhang

Objectives: The rapidly evolving organ failure and high short-run mortality of acute-on-chronic liver failure (ACLF) are inseparable from the role of systemic inflammatory response. S100A8 and S100A9 are associated with the excessive cytokine storm and play a decisive part within the process of inflammation. We aimed to clarify the role of them in predicting prognosis of hepatitis B virus-related ACLF (HBV-ACLF).

Methods: S100A8 and S100A9 levels were analyzed in plasma of 187 transplant-free HBV-ACLF patients, 28 healthy controls and 40 chronic hepatitis B (CHB) patients. S100A8 and S100A9 mRNAs were checked in liver samples from 32 HBV-ACLF patients with liver transplantation, 19 patients undergoing surgery for hepatic hemangioma and 10 CHB patients with needle biopsy.

Results: The plasma levels of the S100A8 and S100A9 were higher in HBV-ACLF patients than in CHB patients (S100A8 : P < 0.001 and S100A9 : P < 0.001) and healthy controls (S100A8 : P < 0.001 and S100A9 : P < 0.001), and similar results were obtained for mRNA expression. Moreover, both proteins were related to ACLF grade, different types of organ failure, and infection, and they correlated with other prognostic scoring systems. S100A8 and S100A9 can dependently predict 28/90-day mortality (28-day: S100A8: hazard ratio (HR): 1.027; 95% confidence interval (CI): 1.007-1.048; P=0.026, S100A9 : HR: 1.009; 95% CI: 1.001-1.017; P=0.007, 90-day: S100A8 : HR: 1.023; 95% CI: 1.011-1.035; P=0.004, S100A9 : HR: 1.008; 95% CI: 1.004-1.012; and P < 0.001). Among all of the scoring systems, the combined scoring model (S100A8 and S100A9 jointly with the Chronic Liver Failure-Consortium Organ Failure score (CLIF-C OFs)) displayed the highest area under the receiver operating curve (0.923 (95% CI, 0.887-0.961)) in the prediction of 90-day mortality.

Conclusions: S100A8 and S100A9 are promising biomarkers for the analysis of risk stratification and prognosis in ACLF patients. In addition, combining them with the CLIF-C OFs may better predict the prognosis of ACLF.

目的:急性慢性肝衰竭(ACLF)快速发展的器官衰竭和高短期死亡率与全身炎症反应的作用是分不开的。S100A8和S100A9与过度的细胞因子风暴有关,在炎症过程中起决定性作用。我们的目的是阐明它们在预测乙型肝炎病毒相关ACLF (HBV-ACLF)预后中的作用。方法:对187例无移植HBV-ACLF患者、28例健康对照和40例慢性乙型肝炎(CHB)患者血浆中S100A8和S100A9水平进行分析。我们在32例HBV-ACLF肝移植患者、19例肝血管瘤手术患者和10例CHB穿刺活检患者的肝脏样本中检测了S100A8和S100A9 mrna。结果:HBV-ACLF患者血浆中S100A8和S100A9水平高于CHB患者(S100A8: P < 0.001和S100A9: P < 0.001)和健康对照组(S100A8: P < 0.001和S100A9: P < 0.001), mRNA表达结果相似。此外,这两种蛋白都与ACLF分级、不同类型的器官衰竭和感染有关,并与其他预后评分系统相关。S100A8和S100A9能独立预测28/90天死亡率(28天:S100A8:风险比(HR): 1.027;95%置信区间(CI): 1.007-1.048;P=0.026, s100a9; hr: 1.009;95% ci: 1.001-1.017;P=0.007, 90天:S100A8: HR: 1.023;95% ci: 1.011-1.035;P=0.004, s100a9; hr: 1.008;95% ci: 1.004-1.012;P < 0.001)。在所有评分系统中,联合评分模型(S100A8和S100A9联合慢性肝功能衰竭-联合脏器功能衰竭评分(clifc - OFs))在预测90天死亡率时,受试者工作曲线下面积最大(0.923 (95% CI, 0.887-0.961))。结论:S100A8和S100A9是分析ACLF患者风险分层和预后的有希望的生物标志物。此外,将其与CLIF-C OFs相结合可以更好地预测ACLF的预后。
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引用次数: 0
Relationship of Helicobacter pylori Infection with Nonalcoholic Fatty Liver Disease: A Meta-Analysis. 幽门螺杆菌感染与非酒精性脂肪肝的关系:一项荟萃分析
IF 2.7 4区 医学 Q2 Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/5521239
Guangqin Xu, Shaoze Ma, Liyan Dong, Nahum Mendez-Sanchez, Hongyu Li, Xingshun Qi

Background and aims: Helicobacter pylori (H. pylori) and nonalcoholic fatty liver disease (NAFLD) have become increasingly recognized, both of which affect human health globally. The association of H. pylori infection with NAFLD remains unclear.

Methods: PubMed, EMBASE, and Cochrane Library databases were searched. Only a random-effects model was used. Odds ratios (ORs) and risk ratios (RRs) with 95% confidence intervals (CIs) were calculated for the combined estimates of raw data. Adjusted ORs (aORs) and hazard ratios (aHRs) with 95% CIs were calculated for the combined estimates of data adjusted for confounders.

Results: Thirty-four studies with 218573 participants were included. Based on unadjusted data from 26 cross-sectional studies and 3 case-control studies, H. pylori infection was significantly associated with the presence of NAFLD (OR = 1.26, 95% CI = 1.17-1.36, P < 0.001). Based on adjusted data from 15 cross-sectional studies and 1 case-control study, H. pylori infection was significantly associated with the presence of NAFLD (aOR = 1.25, 95% CI = 1.08-1.44, P < 0.001). Compared with control subjects without NAFLD, patients with moderate (OR = 1.67, 95% CI = 1.17-2.39, P = 0.005) and severe (OR = 1.71, 95% CI = 1.30-2.24, P < 0.001) NAFLD, but not those with mild NAFLD (OR = 1.14, 95% CI = 0.9-1.45, P = 0.286), had significantly higher proportions of H. pylori infection. The association of H. pylori infection with the occurrence of NAFLD was statistically significant based on adjusted data from 3 cohort studies (aHR = 1.18, 95% CI = 1.05-1.34, P = 0.007), but not based on unadjusted data from 3 cohort studies (RR = 1.41, 95% CI = 0.80-2.48, P = 0.237).

Conclusion: H. pylori infection is associated with NAFLD, especially moderate and severe NAFLD. The impact of H. pylori eradication on the prevention of NAFLD should be further explored.

背景和目的:幽门螺杆菌(h.p ylori)和非酒精性脂肪性肝病(NAFLD)越来越受到重视,两者都影响着全球人类健康。幽门螺杆菌感染与NAFLD的关系尚不清楚。方法:检索PubMed、EMBASE和Cochrane图书馆数据库。只使用了随机效应模型。对原始数据的综合估计计算95%置信区间(ci)的优势比(ORs)和风险比(rr)。对经混杂因素调整后的数据进行合并估计,计算95% ci的调整后or (aORs)和风险比(aHRs)。结果:34项研究共纳入218573名受试者。基于来自26个横断面研究和3个病例对照研究的未经调整的数据,幽门螺杆菌感染与NAFLD的存在显著相关(OR = 1.26, 95% CI = 1.17-1.36, P < 0.001)。根据15项横断面研究和1项病例对照研究的校正数据,幽门螺杆菌感染与NAFLD存在显著相关(aOR = 1.25, 95% CI = 1.08-1.44, P < 0.001)。与非NAFLD对照组相比,中度NAFLD患者(OR = 1.67, 95% CI = 1.17-2.39, P = 0.005)和重度NAFLD患者(OR = 1.71, 95% CI = 1.30-2.24, P < 0.001)幽门螺杆菌感染比例显著高于轻度NAFLD患者(OR = 1.14, 95% CI = 0.9% -1.45, P = 0.286)。根据3项队列研究的校正数据,幽门螺杆菌感染与NAFLD发生的相关性有统计学意义(aHR = 1.18, 95% CI = 1.05-1.34, P = 0.007),但根据3项队列研究的未校正数据,幽门螺杆菌感染与NAFLD发生的相关性无统计学意义(RR = 1.41, 95% CI = 0.80-2.48, P = 0.237)。结论:幽门螺杆菌感染与NAFLD相关,尤其是中重度NAFLD。根除幽门螺杆菌对NAFLD预防的影响有待进一步探讨。
{"title":"Relationship of <i>Helicobacter pylori</i> Infection with Nonalcoholic Fatty Liver Disease: A Meta-Analysis.","authors":"Guangqin Xu,&nbsp;Shaoze Ma,&nbsp;Liyan Dong,&nbsp;Nahum Mendez-Sanchez,&nbsp;Hongyu Li,&nbsp;Xingshun Qi","doi":"10.1155/2023/5521239","DOIUrl":"https://doi.org/10.1155/2023/5521239","url":null,"abstract":"<p><strong>Background and aims: </strong><i>Helicobacter pylori</i> (<i>H. pylori</i>) and nonalcoholic fatty liver disease (NAFLD) have become increasingly recognized, both of which affect human health globally. The association of <i>H. pylori</i> infection with NAFLD remains unclear.</p><p><strong>Methods: </strong>PubMed, EMBASE, and Cochrane Library databases were searched. Only a random-effects model was used. Odds ratios (ORs) and risk ratios (RRs) with 95% confidence intervals (CIs) were calculated for the combined estimates of raw data. Adjusted ORs (aORs) and hazard ratios (aHRs) with 95% CIs were calculated for the combined estimates of data adjusted for confounders.</p><p><strong>Results: </strong>Thirty-four studies with 218573 participants were included. Based on unadjusted data from 26 cross-sectional studies and 3 case-control studies, <i>H. pylori</i> infection was significantly associated with the presence of NAFLD (OR = 1.26, 95% CI = 1.17-1.36, <i>P</i> < 0.001). Based on adjusted data from 15 cross-sectional studies and 1 case-control study, <i>H. pylori</i> infection was significantly associated with the presence of NAFLD (aOR = 1.25, 95% CI = 1.08-1.44, <i>P</i> < 0.001). Compared with control subjects without NAFLD, patients with moderate (OR = 1.67, 95% CI = 1.17-2.39, <i>P</i> = 0.005) and severe (OR = 1.71, 95% CI = 1.30-2.24, <i>P</i> < 0.001) NAFLD, but not those with mild NAFLD (OR = 1.14, 95% CI = 0.9-1.45, <i>P</i> = 0.286), had significantly higher proportions of <i>H. pylori</i> infection. The association of <i>H. pylori</i> infection with the occurrence of NAFLD was statistically significant based on adjusted data from 3 cohort studies (aHR = 1.18, 95% CI = 1.05-1.34, <i>P</i> = 0.007), but not based on unadjusted data from 3 cohort studies (RR = 1.41, 95% CI = 0.80-2.48, <i>P</i> = 0.237).</p><p><strong>Conclusion: </strong><i>H. pylori</i> infection is associated with NAFLD, especially moderate and severe NAFLD. The impact of <i>H. pylori</i> eradication on the prevention of NAFLD should be further explored.</p>","PeriodicalId":48755,"journal":{"name":"Canadian Journal of Gastroenterology and Hepatology","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9623390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Gambogic Acid Inhibits Gastric Cancer Cell Proliferation through Necroptosis. 藤黄酸通过坏死坏死抑制胃癌细胞增殖。
IF 2.7 4区 医学 Q2 Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/7532367
Shujun Wang, Yiping Wang, Hui Zhu, Miaohui Chen, Liang Zhang

Gambogic acid (GA) is a natural xanthonoid secreted by Garcinia hanburyi tree. It possesses anti-cancer activity in various types of cancers. In gastric cancer, it inhibits cell proliferation through increasing apoptosis. However, whether necroptosis is involved in the GA-induced proliferation inhibited in gastric cancer is unknown. In the present study, we found that RIPK1 specific inhibitor necrostatin-1 (Nec-1) attenuated GA-induced proliferation inhibition. GA treatment increased the phosphorylation of necroptosis-related proteins, RIPK1, RIPK3, and MLKL, and their interactions to form the necrosome complex. The effector protein Drp-1 was dephosphorylated by GA treatment. Inhibition of necroptosis by different inhibitors and PGAM5 knockdown attenuated GA-induced cell death in gastric cancer cell lines, thereby attenuating GA-caused cell proliferation inhibition. All the data supported the conclusion that GA could inhibit gastric cancer cell proliferation by inducing necroptosis.

藤黄酸(Gambogic acid, GA)是藤黄属植物分泌的一种天然类黄嘌呤。它对各种类型的癌症都具有抗癌活性。在胃癌中,它通过增加细胞凋亡抑制细胞增殖。然而,胃癌中ga诱导的增殖被抑制是否与坏死性上睑下垂有关尚不清楚。在本研究中,我们发现RIPK1特异性抑制剂坏死他汀-1 (nec1)可减弱ga诱导的增殖抑制。GA处理增加了坏死相关蛋白RIPK1、RIPK3和MLKL的磷酸化,以及它们之间形成坏死体复合物的相互作用。效应蛋白Drp-1经GA处理后去磷酸化。不同抑制剂和PGAM5敲低抑制坏死性下垂可减轻ga诱导的胃癌细胞系细胞死亡,从而减轻ga引起的细胞增殖抑制。所有数据均支持GA通过诱导坏死下垂抑制胃癌细胞增殖的结论。
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引用次数: 0
The Impact of Serum Parameters Associated with Kidney Function on the Short-Term Outcomes and Prognosis of Colorectal Cancer Patients Undergoing Radical Surgery. 与肾功能相关的血清参数对大肠癌根治性手术患者短期预后的影响
IF 2.7 4区 医学 Q2 Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/2017171
Bin Zhang, Xu-Rui Liu, Xiao-Yu Liu, Bing Kang, Chao Yuan, Fei Liu, Zi-Wei Li, Zheng-Qiang Wei, Dong Peng

Purpose: The current study was designed to investigate the impact of blood urea nitrogen (BUN), serum uric acid (UA), and cystatin (CysC) on the short-term outcomes and prognosis of colorectal cancer (CRC) patients undergoing radical surgery.

Methods: CRC patients who underwent radical resection were included from Jan 2011 to Jan 2020 in a single clinical centre. The short-term outcomes, overall survival (OS), and disease-free survival (DFS) were compared in different groups. A Cox regression analysis was conducted to identify independent risk factors for OS and DFS.

Results: A total of 2047 CRC patients who underwent radical resection were included in the current study. Patients in the abnormal BUN group had a longer hospital stay (p=0.002) and more overall complications (p=0.001) than that of the normal BUN group. The abnormal CysC group had longer hospital stay (p < 0.01), more overall complications (p=p < 0.01), and more major complications (p=0.001) than the normal CysC group. Abnormal CysC was associated with worse OS and DFS for CRC patients in tumor stage I (p < 0.01). In Cox regression analysis, age (p < 0.01, HR = 1.041, 95% CI = 1.029-1.053), tumor stage (p < 0.01, HR = 2.134, 95% CI = 1.828-2.491), and overall complications (p=0.002, HR = 1.499, 95% CI = 1.166-1.928) were independent risk factors for OS. Similarly, age (p < 0.01, HR = 1.026, 95% CI = 1.016-1.037), tumor stage (p < 0.01, HR = 2.053, 95% CI = 1.788-2.357), and overall complications (p=0.002, HR = 1.440, 95% CI = 1.144-1.814) were independent risk factors for DFS.

Conclusion: In conclusion, abnormal CysC was significantly associated with worse OS and DFS at TNM stage I, and abnormal CysC and BUN were related to more postoperative complications. However, preoperative BUN and UA in the serum might not affect OS and DFS for CRC patients who underwent radical resection.

目的:本研究旨在探讨血尿素氮(BUN)、血清尿酸(UA)和胱抑素(CysC)对大肠癌(CRC)根治性手术患者短期预后和预后的影响。方法:纳入2011年1月至2020年1月在单一临床中心接受根治性切除术的结直肠癌患者。比较不同组的短期预后、总生存期(OS)和无病生存期(DFS)。采用Cox回归分析确定OS和DFS的独立危险因素。结果:本研究共纳入2047例行根治性切除术的结直肠癌患者。与BUN正常组相比,BUN异常组患者住院时间更长(p=0.002),总并发症更多(p=0.001)。CysC异常组比CysC正常组住院时间长(p < 0.01),总并发症多(p=p < 0.01),主要并发症多(p=0.001)。肿瘤I期CRC患者CysC异常与较差的OS和DFS相关(p < 0.01)。Cox回归分析中,年龄(p < 0.01, HR = 1.041, 95% CI = 1.029 ~ 1.053)、肿瘤分期(p < 0.01, HR = 2.134, 95% CI = 1.828 ~ 2.491)、总并发症(p=0.002, HR = 1.499, 95% CI = 1.166 ~ 1.928)是OS的独立危险因素。同样,年龄(p < 0.01, HR = 1.026, 95% CI = 1.016 ~ 1.037)、肿瘤分期(p < 0.01, HR = 2.053, 95% CI = 1.788 ~ 2.357)、总并发症(p=0.002, HR = 1.440, 95% CI = 1.144 ~ 1.814)是DFS的独立危险因素。结论:综上所述,CysC异常与TNM I期OS和DFS恶化有显著相关,CysC和BUN异常与更多的术后并发症相关。然而,术前血清BUN和UA可能不会影响行根治性切除术的结直肠癌患者的OS和DFS。
{"title":"The Impact of Serum Parameters Associated with Kidney Function on the Short-Term Outcomes and Prognosis of Colorectal Cancer Patients Undergoing Radical Surgery.","authors":"Bin Zhang,&nbsp;Xu-Rui Liu,&nbsp;Xiao-Yu Liu,&nbsp;Bing Kang,&nbsp;Chao Yuan,&nbsp;Fei Liu,&nbsp;Zi-Wei Li,&nbsp;Zheng-Qiang Wei,&nbsp;Dong Peng","doi":"10.1155/2023/2017171","DOIUrl":"https://doi.org/10.1155/2023/2017171","url":null,"abstract":"<p><strong>Purpose: </strong>The current study was designed to investigate the impact of blood urea nitrogen (BUN), serum uric acid (UA), and cystatin (CysC) on the short-term outcomes and prognosis of colorectal cancer (CRC) patients undergoing radical surgery.</p><p><strong>Methods: </strong>CRC patients who underwent radical resection were included from Jan 2011 to Jan 2020 in a single clinical centre. The short-term outcomes, overall survival (OS), and disease-free survival (DFS) were compared in different groups. A Cox regression analysis was conducted to identify independent risk factors for OS and DFS.</p><p><strong>Results: </strong>A total of 2047 CRC patients who underwent radical resection were included in the current study. Patients in the abnormal BUN group had a longer hospital stay (<i>p</i>=0.002) and more overall complications (<i>p</i>=0.001) than that of the normal BUN group. The abnormal CysC group had longer hospital stay (<i>p</i> < 0.01), more overall complications (<i>p</i>=<i>p</i> < 0.01), and more major complications (<i>p</i>=0.001) than the normal CysC group. Abnormal CysC was associated with worse OS and DFS for CRC patients in tumor stage I (<i>p</i> < 0.01). In Cox regression analysis, age (<i>p</i> < 0.01, HR = 1.041, 95% CI = 1.029-1.053), tumor stage (<i>p</i> < 0.01, HR = 2.134, 95% CI = 1.828-2.491), and overall complications (<i>p</i>=0.002, HR = 1.499, 95% CI = 1.166-1.928) were independent risk factors for OS. Similarly, age (<i>p</i> < 0.01, HR = 1.026, 95% CI = 1.016-1.037), tumor stage (<i>p</i> < 0.01, HR = 2.053, 95% CI = 1.788-2.357), and overall complications (<i>p</i>=0.002, HR = 1.440, 95% CI = 1.144-1.814) were independent risk factors for DFS.</p><p><strong>Conclusion: </strong>In conclusion, abnormal CysC was significantly associated with worse OS and DFS at TNM stage I, and abnormal CysC and BUN were related to more postoperative complications. However, preoperative BUN and UA in the serum might not affect OS and DFS for CRC patients who underwent radical resection.</p>","PeriodicalId":48755,"journal":{"name":"Canadian Journal of Gastroenterology and Hepatology","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9089965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of Drug-Eluting Bead TACE in the Treatment of Primary or Secondary Liver Cancer. 药物洗脱珠TACE治疗原发性或继发性肝癌的疗效和安全性。
IF 2.7 4区 医学 Q2 Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/5492931
Jiabing Wang, Haoqian Xu, Ying Wang, Long Feng, Fengming Yi

Background: The drug-eluting beads transarterial chemoembolization (DEB-TACE) has already been used in hepatic malignancies. We aim to evaluate the efficacy and safety of DEB-TACE in treating primary or secondary liver cancer.

Methods: We retrospectively evaluated 59 patients with hepatic malignancies, including 41 patients with primary liver cancer and 18 patients with secondary liver cancer, between September 2016 and February 2019. All patients were treated with DEB-TACE. Objective response rate (ORR) and disease control rate (DCR) were evaluated by mRECIST. The pain was assessed using a numerical rating scale (NRS) where 0 represented no pain, and a score of ten was unbearable. Adverse reactions were assessed according to Common Terminology Criteria for Adverse Events 4.0 (CTCAE4.0).

Results: In the subgroup of primary liver cancer, 3 patients (7.32%) got complete response, 13 patients (31.71%) got partial response, 21 patients (51.22%) experienced stable disease, and 4 patients (9.76%) suffered progressive disease; ORR was 39.02% and DCR was 90.24%. In the subgroup of secondary liver cancer, 0 patients (0%) got complete response, 6 patients (33.33%) got partial response, 11 patients (61.11%) experienced stable disease, and 1 patient (5.56%) suffered progressive disease; ORR was 33.33% and DCR was 94.44%. We did not find any difference when comparing the efficacy between primary and secondary liver cancer (P=0.612). The one-year survival rate was 70.73% for primary liver cancer and 61.11% for secondary liver cancer. There was no significant difference between the two groups (P=0.52). For the patients with CR or PR, no factor could predict the efficacy of DEB-TACE. The most common treatment-related adverse reactions were short-term liver function disorders. The symptoms included fever (20.34%), abdomen pain (16.95%), and vomiting (5.08%), all patients with adverse reactions got remission after treatment.

Conclusions: DEB-TACE has a promising effect in the treatment of primary or secondary liver cancer. The treatment-related adverse reactions are tolerable.

背景:药物洗脱珠经动脉化疗栓塞(DEB-TACE)已在肝脏恶性肿瘤中得到应用。我们的目的是评价DEB-TACE治疗原发性或继发性肝癌的疗效和安全性。方法:回顾性评估2016年9月至2019年2月期间59例肝脏恶性肿瘤患者,其中41例为原发性肝癌,18例为继发性肝癌。所有患者均接受DEB-TACE治疗。采用mRECIST评估客观缓解率(ORR)和疾病控制率(DCR)。疼痛采用数值评定量表(NRS)进行评估,0分代表无疼痛,10分代表无法忍受。不良反应按照不良事件通用术语标准4.0 (CTCAE4.0)进行评估。结果:原发性肝癌亚组中完全缓解3例(7.32%),部分缓解13例(31.71%),病情稳定21例(51.22%),病情进展4例(9.76%);ORR为39.02%,DCR为90.24%。在继发性肝癌亚组中,完全缓解0例(0%),部分缓解6例(33.33%),病情稳定11例(61.11%),进展1例(5.56%);ORR为33.33%,DCR为94.44%。原发性肝癌与继发性肝癌的疗效比较无差异(P=0.612)。原发性肝癌1年生存率为70.73%,继发性肝癌1年生存率为61.11%。两组间差异无统计学意义(P=0.52)。对于CR或PR患者,没有任何因素可以预测DEB-TACE的疗效。最常见的治疗相关不良反应是短期肝功能障碍。症状为发热(20.34%)、腹痛(16.95%)、呕吐(5.08%),治疗后不良反应全部缓解。结论:DEB-TACE治疗原发性或继发性肝癌有良好的疗效。治疗相关的不良反应是可以容忍的。
{"title":"Efficacy and Safety of Drug-Eluting Bead TACE in the Treatment of Primary or Secondary Liver Cancer.","authors":"Jiabing Wang,&nbsp;Haoqian Xu,&nbsp;Ying Wang,&nbsp;Long Feng,&nbsp;Fengming Yi","doi":"10.1155/2023/5492931","DOIUrl":"https://doi.org/10.1155/2023/5492931","url":null,"abstract":"<p><strong>Background: </strong>The drug-eluting beads transarterial chemoembolization (DEB-TACE) has already been used in hepatic malignancies. We aim to evaluate the efficacy and safety of DEB-TACE in treating primary or secondary liver cancer.</p><p><strong>Methods: </strong>We retrospectively evaluated 59 patients with hepatic malignancies, including 41 patients with primary liver cancer and 18 patients with secondary liver cancer, between September 2016 and February 2019. All patients were treated with DEB-TACE. Objective response rate (ORR) and disease control rate (DCR) were evaluated by mRECIST. The pain was assessed using a numerical rating scale (NRS) where 0 represented no pain, and a score of ten was unbearable. Adverse reactions were assessed according to Common Terminology Criteria for Adverse Events 4.0 (CTCAE4.0).</p><p><strong>Results: </strong>In the subgroup of primary liver cancer, 3 patients (7.32%) got complete response, 13 patients (31.71%) got partial response, 21 patients (51.22%) experienced stable disease, and 4 patients (9.76%) suffered progressive disease; ORR was 39.02% and DCR was 90.24%. In the subgroup of secondary liver cancer, 0 patients (0%) got complete response, 6 patients (33.33%) got partial response, 11 patients (61.11%) experienced stable disease, and 1 patient (5.56%) suffered progressive disease; ORR was 33.33% and DCR was 94.44%. We did not find any difference when comparing the efficacy between primary and secondary liver cancer (<i>P</i>=0.612). The one-year survival rate was 70.73% for primary liver cancer and 61.11% for secondary liver cancer. There was no significant difference between the two groups (<i>P</i>=0.52). For the patients with CR or PR, no factor could predict the efficacy of DEB-TACE. The most common treatment-related adverse reactions were short-term liver function disorders. The symptoms included fever (20.34%), abdomen pain (16.95%), and vomiting (5.08%), all patients with adverse reactions got remission after treatment.</p><p><strong>Conclusions: </strong>DEB-TACE has a promising effect in the treatment of primary or secondary liver cancer. The treatment-related adverse reactions are tolerable.</p>","PeriodicalId":48755,"journal":{"name":"Canadian Journal of Gastroenterology and Hepatology","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9442397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical Management of Recurrence of Primary Intrahepatic Bile Duct Stones. 原发性肝内胆管结石复发的外科治疗。
IF 2.7 4区 医学 Q2 Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/5158580
HongTian Xia, HangYu Zhang, XianLei Xin, Bin Liang, Tao Yang, Yang Liu, Jing Wang, XiangFei Meng

Background: The surgical treatment of primary intrahepatic bile duct stones is associated with high rates of postoperative complications, stone recurrence, and reoperation. This study aimed to report an 11-year experience in the management of postoperative recurrence of intrahepatic bile duct stones, analyze the causes of the reoperation, and establish appropriate surgical procedures.

Materials and methods: The records of 148 patients with postoperative recurrence of primary intrahepatic bile duct stones treated from January 2005 to December 2015 were retrospectively reviewed. Prior surgical treatment and postoperative data were analyzed to investigate possible causes of recurrence and reoperation.

Results: All patients with a prior cholangiojejunostomy (n = 61) developed biliary stenosis (100%). Of the 86 patients without cholangiojejunostomy, 71 (82.56%) had abnormalities in the structure and function of the lower end of the common bile duct, and 86 had hilar and intrahepatic bile duct stenosis. Of all 148 patients, 136 (91.89%) had positive intraoperative bile cultures. Patients were treated with a modified surgical procedure, and the combined excellent and good rate of long-term outcomes reached 85.48% (106/124). The stone recurrence rate of the 124 patients decreased from 100% (124/124) of the prior operation to 5.65% (7/124) during the reoperation.

Conclusions: The pathogenesis of primary intrahepatic bile duct stones is associated with biliary infection and intrahepatic bile duct cholestasis. According to the etiology and pathogenic mechanism, surgical procedures that improve long-term outcomes and reduce postoperative recurrence include bile duct exploration with stone extraction, partial hepatectomy, hilar ductoplasty, and Roux-en-Y hepaticojejunostomy.

背景:原发性肝内胆管结石的手术治疗与术后并发症、结石复发和再手术的高发率有关。本研究旨在报告11年来处理肝内胆管结石术后复发的经验,分析再次手术的原因,建立合适的手术方法。材料与方法:回顾性分析2005年1月至2015年12月收治的148例原发性肝内胆管结石术后复发患者的资料。分析既往手术治疗及术后资料,探讨复发及再手术的可能原因。结果:所有既往行胆管空肠吻合术的患者(61例)均出现胆道狭窄(100%)。未行胆管空肠吻合术的86例患者中,总胆管下端结构及功能异常71例(82.56%),肝门及肝内胆管狭窄86例。148例患者中,136例(91.89%)术中胆汁培养阳性。采用改良手术方式治疗,远期疗效优良率达85.48%(106/124)。124例患者再次手术时结石复发率由术前100%(124/124)降至5.65%(7/124)。结论:原发性肝内胆管结石的发病机制与胆道感染和肝内胆管胆汁淤积有关。根据病因和发病机制,改善远期疗效和减少术后复发的手术包括胆管探查取石术、肝部分切除术、肝门管成形术和Roux-en-Y肝空肠吻合术。
{"title":"Surgical Management of Recurrence of Primary Intrahepatic Bile Duct Stones.","authors":"HongTian Xia,&nbsp;HangYu Zhang,&nbsp;XianLei Xin,&nbsp;Bin Liang,&nbsp;Tao Yang,&nbsp;Yang Liu,&nbsp;Jing Wang,&nbsp;XiangFei Meng","doi":"10.1155/2023/5158580","DOIUrl":"https://doi.org/10.1155/2023/5158580","url":null,"abstract":"<p><strong>Background: </strong>The surgical treatment of primary intrahepatic bile duct stones is associated with high rates of postoperative complications, stone recurrence, and reoperation. This study aimed to report an 11-year experience in the management of postoperative recurrence of intrahepatic bile duct stones, analyze the causes of the reoperation, and establish appropriate surgical procedures.</p><p><strong>Materials and methods: </strong>The records of 148 patients with postoperative recurrence of primary intrahepatic bile duct stones treated from January 2005 to December 2015 were retrospectively reviewed. Prior surgical treatment and postoperative data were analyzed to investigate possible causes of recurrence and reoperation.</p><p><strong>Results: </strong>All patients with a prior cholangiojejunostomy (<i>n</i> = 61) developed biliary stenosis (100%). Of the 86 patients without cholangiojejunostomy, 71 (82.56%) had abnormalities in the structure and function of the lower end of the common bile duct, and 86 had hilar and intrahepatic bile duct stenosis. Of all 148 patients, 136 (91.89%) had positive intraoperative bile cultures. Patients were treated with a modified surgical procedure, and the combined excellent and good rate of long-term outcomes reached 85.48% (106/124). The stone recurrence rate of the 124 patients decreased from 100% (124/124) of the prior operation to 5.65% (7/124) during the reoperation.</p><p><strong>Conclusions: </strong>The pathogenesis of primary intrahepatic bile duct stones is associated with biliary infection and intrahepatic bile duct cholestasis. According to the etiology and pathogenic mechanism, surgical procedures that improve long-term outcomes and reduce postoperative recurrence include bile duct exploration with stone extraction, partial hepatectomy, hilar ductoplasty, and Roux-en-Y hepaticojejunostomy.</p>","PeriodicalId":48755,"journal":{"name":"Canadian Journal of Gastroenterology and Hepatology","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10636935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disparate Intent-to-Treat Outcomes for Pediatric Liver Transplantation Based on Indication. 基于适应症的儿童肝移植不同意向治疗结果。
IF 2.7 4区 医学 Q2 Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/2859384
Anna Lang, Cameron Goff, Ashley Montgomery, Jake Lynn, Spoorthi Kamepalli, John Goss, Abbas Rana

Background: The impact of indication for pediatric liver transplantation on waitlist and post-transplant mortality outcomes is well known, but the impact on intent-to-treat outcomes has not been investigated. Intent-to-treat survival analysis is important in this study because it is more comprehensive, combining the transplant outcomes of waitlist mortality, post-transplant mortality, and transplant rate into a single metric to elucidate any disparities in outcomes based on indication.

Methods: Cox regression was used to analyze factors impacting survival in 8,002 children listed for liver transplant in the UNOS database between 2006 and 2016. The Kaplan-Meier method and log-rank test were used to assess differences in waitlist, post-transplant, and intent-to-treat mortality among the top 5 indications of biliary atresia, acute hepatic necrosis, metabolic disorders, hepatoblastoma, and autoimmune cirrhosis.

Results: When compared to the reference group of biliary atresia, multivariate analyses showed that every indication was associated with inferior intent-to-treat outcomes except for metabolic disorders. Hepatoblastoma (hazard ratio (HR): 3.73), autoimmune cirrhosis (HR: 1.86), and AHN (HR: 1.77) were associated with significantly increased intent-to-treat mortality. Hepatoblastoma was also associated with increased post-transplant mortality (HR: 3.77) and was the only indication significantly associated with increased waitlist mortality (HR: 6.43).

Conclusion: Significant disparity exists across all indications with respect to an increased intent-to-treat mortality, along with an increased post-transplant and waitlist mortality, when compared to the biliary atresia reference group. If further studies validate these findings, a reexamination of the equitable distribution of allografts for transplant may be warranted as well as a focus on disparities in survival after transplant.

背景:小儿肝移植指征对等待名单和移植后死亡率的影响是众所周知的,但对治疗意向的影响尚未调查。意向治疗生存分析在本研究中很重要,因为它更全面,将等待名单死亡率、移植后死亡率和移植率的移植结果结合为一个单一的指标,以阐明基于适应症的结果的任何差异。方法:采用Cox回归分析2006年至2016年UNOS数据库中8,002例肝移植患儿的影响生存因素。Kaplan-Meier法和log-rank检验用于评估前5种指征胆道闭锁、急性肝坏死、代谢性疾病、肝母细胞瘤和自身免疫性肝硬化的等待名单、移植后和意向治疗死亡率的差异。结果:与胆道闭锁参照组相比,多变量分析显示,除代谢紊乱外,所有适应症均与较差的意向治疗结果相关。肝母细胞瘤(风险比(HR): 3.73)、自身免疫性肝硬化(HR: 1.86)和AHN (HR: 1.77)与意向治疗死亡率显著增加相关。肝母细胞瘤也与移植后死亡率增加相关(HR: 3.77),并且是唯一与等待名单死亡率增加显著相关的适应症(HR: 6.43)。结论:与胆道闭锁参照组相比,在有意治疗死亡率增加、移植后和等待名单死亡率增加方面,所有适应症都存在显著差异。如果进一步的研究证实了这些发现,重新检查同种异体移植物移植的公平分配可能是必要的,并关注移植后生存的差异。
{"title":"Disparate Intent-to-Treat Outcomes for Pediatric Liver Transplantation Based on Indication.","authors":"Anna Lang,&nbsp;Cameron Goff,&nbsp;Ashley Montgomery,&nbsp;Jake Lynn,&nbsp;Spoorthi Kamepalli,&nbsp;John Goss,&nbsp;Abbas Rana","doi":"10.1155/2023/2859384","DOIUrl":"https://doi.org/10.1155/2023/2859384","url":null,"abstract":"<p><strong>Background: </strong>The impact of indication for pediatric liver transplantation on waitlist and post-transplant mortality outcomes is well known, but the impact on intent-to-treat outcomes has not been investigated. Intent-to-treat survival analysis is important in this study because it is more comprehensive, combining the transplant outcomes of waitlist mortality, post-transplant mortality, and transplant rate into a single metric to elucidate any disparities in outcomes based on indication.</p><p><strong>Methods: </strong>Cox regression was used to analyze factors impacting survival in 8,002 children listed for liver transplant in the UNOS database between 2006 and 2016. The Kaplan-Meier method and log-rank test were used to assess differences in waitlist, post-transplant, and intent-to-treat mortality among the top 5 indications of biliary atresia, acute hepatic necrosis, metabolic disorders, hepatoblastoma, and autoimmune cirrhosis.</p><p><strong>Results: </strong>When compared to the reference group of biliary atresia, multivariate analyses showed that every indication was associated with inferior intent-to-treat outcomes except for metabolic disorders. Hepatoblastoma (hazard ratio (HR): 3.73), autoimmune cirrhosis (HR: 1.86), and AHN (HR: 1.77) were associated with significantly increased intent-to-treat mortality. Hepatoblastoma was also associated with increased post-transplant mortality (HR: 3.77) and was the only indication significantly associated with increased waitlist mortality (HR: 6.43).</p><p><strong>Conclusion: </strong>Significant disparity exists across all indications with respect to an increased intent-to-treat mortality, along with an increased post-transplant and waitlist mortality, when compared to the biliary atresia reference group. If further studies validate these findings, a reexamination of the equitable distribution of allografts for transplant may be warranted as well as a focus on disparities in survival after transplant.</p>","PeriodicalId":48755,"journal":{"name":"Canadian Journal of Gastroenterology and Hepatology","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9110471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Population- and Gender-Based Investigation for Prevalence of Helicobacter pylori in Dhamar, Yemen. 也门达马市幽门螺杆菌患病率人口和性别调查。
IF 2.7 4区 医学 Q2 Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/3800810
Dhary A Almashhadany, Sara M Mayas, Hero I Mohammed, Abdulwahed A Hassan, Izhar U H Khan

Among 35 species of genus Helicobacter, H. pylori is the most common causative agent of human gastritis, peptic ulcer, and gastric cancer. The infection can spread through direct human-to-human contact, fecal-oral route, and contaminated water. The study was designed to investigate the rate of prevalence of H. pylori in the population of Dhamar, Yemen. In this one-year study, 460 including 250 male and 210 female stool specimens were collected between January to December 2020 in Dhamar Governorate, Yemen. Of the total 460, 215 rural (male: n = 120 and female: n = 95) and 245 urban (male: n = 130 and female: n = 115) specimens were investigated for identification of H. pylori by serological test using Helicobacter pylori stool antigen (HpSA) test. In addition, for comparing an improved recovery of H. pylori, conventional culture-based isolation was also carried out using three selective media. Modified Campy-blood Agar (MCA), Belo Horizonte Agar (BHA), and Egg yolk Emulsion (EYE) medium supplemented with antimicrobial agents including vancomycin (10 mg/L), cefsulodin (5 mg/L), trimethoprim (5 mg/L), and amphotericin B (5 mg/L) and isolates were phenotypically characterized. The HpSA test results revealed that of the total 460 specimens, 89 (19.3%) were positive for H. pylori with relatively low in male (n = 43; 17.2%) as compared to the female (n = 46; 21.9%) specimens. After 3-10 days of incubation, H. pylori was recovered at a variable rate on each selective (MCA: 16.5%; BHA: 15.0%; EYE: 13.0%) media. However, culture-based assay results showed less recovery (n = 81; 17.6%) with no significant difference among all selective media tested and between genders (male: n = 39; 15.6%; female: n = 42; 20.0%). The infection rate was comparatively higher in rural (n = 45; 20.9%) as compared to urban (n = 36; 14.7%) population. Overall, the study data showed the prevalence of infection in both genders of all age groups. The present study showed a relatively high rate of infection of H. pylori in the Dhamar population. The serological identification and culture-based methods are important for rapid detection, aid in treatment, and developing policies for the control and eradication of H. pylori infection and to prevent the disease in different age groups in Yemen.

幽门螺杆菌属35种中,幽门螺杆菌是人类胃炎、消化性溃疡和胃癌最常见的病原体。感染可通过人与人之间的直接接触、粪口途径和受污染的水传播。该研究旨在调查也门达马尔人口中幽门螺杆菌的患病率。在这项为期一年的研究中,于2020年1月至12月在也门达马尔省收集了460份粪便标本,其中包括250名男性和210名女性。460例中,215例农村(男120例,女95例)和245例城市(男130例,女115例)采用幽门螺杆菌粪便抗原(HpSA)血清学检测进行幽门螺杆菌鉴定。此外,为了比较幽门螺杆菌回收率的提高,还使用三种选择性培养基进行了常规培养分离。在添加万古霉素(10mg /L)、头孢氯丁(5mg /L)、甲氧苄啶(5mg /L)和两性霉素B (5mg /L)等抗菌剂的培养基中,对改良的Campy-blood琼脂(MCA)、Belo Horizonte琼脂(BHA)和蛋黄乳(EYE)培养基进行表型表征。HpSA检测结果显示,460份标本中幽门螺杆菌阳性89份(19.3%),其中男性较少(n = 43;17.2%)与女性相比(n = 46;21.9%)标本。孵育3-10 d后,幽门螺杆菌在各选择性培养基上的回收率不同(MCA: 16.5%;底部钻具组合:15.0%;EYE: 13.0%)介质。然而,基于培养的检测结果显示回收率较低(n = 81;17.6%),在所有测试的选择性介质之间和性别之间无显著差异(男性:n = 39;15.6%;女性:n = 42;20.0%)。农村感染率较高(n = 45;20.9%)与城市(n = 36;人口14.7%)。总体而言,研究数据显示,所有年龄组的男女感染率都很高。目前的研究表明,幽门螺杆菌的感染率相对较高的人口达玛尔。血清学鉴定和基于培养的方法对于快速发现、帮助治疗、制定控制和根除幽门螺杆菌感染的政策以及预防也门不同年龄组的疾病非常重要。
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引用次数: 2
Prediction of Liver Steatosis and Fibrosis Based on Clinical Variables Using a Large National Survey Database. 基于临床变量的肝脂肪变性和肝纤维化预测使用大型国家调查数据库。
IF 2.7 4区 医学 Q2 Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/1791500
Yanal Alnimer, Touleen Alnimer

Background: Vibration-controlled transient elastography (VCTA) and controlled attenuation parameter (CAP) are used more frequently to diagnose liver fibrosis and steatosis among nonalcoholic fatty liver disease patients. However, limited robust data are available on the clinical variables strongly related to these disorders and who needs to be referred for screening.

Methods: We used the National Health and Nutritional Examination Survey 2017-2018 database to identify the clinical predictors strongly related to liver steatosis and advanced fibrosis. Baseline comparisons among these groups were made based on widely accepted cutoffs. Linear and logistic regressions were performed to identify the associations between the clinical variables and liver steatosis and fibrosis. We used adaptive lasso regression, gradient-boosted model, and decision trees to determine clinical variables strongly related to these outcomes. A Naïve Byes classifier and decision trees were used to calculate the predicted probabilities of liver steatosis and fibrosis.

Results: 32% of our population had evidence of liver steatosis using 294 dB/m as a cutoff. An increase in age, serum triglyceride, and body mass index were associated with a statistically significant increase in liver steatosis; in contrast, females had statistically significantly lower values for liver steatosis by 15 points in the multivariable linear regression model. Serum LDL, smoking, and systolic and diastolic blood pressure are poorly associated with liver steatosis in the adaptive lasso regression. On the other hand, sex, tobacco use, metabolic energy expenditure, and serum triglyceride are the least associated with liver fibrosis based on decision tree analysis and a gradient-boosted model. In decision trees, people with a body mass index above 30 and HbA1c above 5.7 have a 72% likelihood of liver steatosis compared to 14% for people with a body mass index below 30. On the other hand, people with a body mass index above 41 have a 38% likelihood of liver fibrosis.

Conclusion: Body mass index, hemoglobin A1c, serum triglyceride level, sex, and age could provide a good prediction for liver steatosis, while body mass index, blood pressure, platelet counts, hemoglobin A1c, serum LDL, or HDL are highly associated with liver fibrosis and should be used as an initial screening tool prior referral for VCTE/CAP.

背景:振动控制瞬态弹性成像(VCTA)和控制衰减参数(CAP)在诊断非酒精性脂肪肝患者的肝纤维化和脂肪变性方面更为常用。然而,关于与这些疾病密切相关的临床变量以及哪些患者需要接受筛查的可靠数据有限。方法:我们使用2017-2018年国家健康与营养检查调查数据库来确定与肝脂肪变性和晚期纤维化密切相关的临床预测因素。这些组之间的基线比较是基于广泛接受的截止值。进行线性和逻辑回归以确定临床变量与肝脂肪变性和纤维化之间的关联。我们使用自适应套索回归、梯度增强模型和决策树来确定与这些结果密切相关的临床变量。使用Naïve Byes分类器和决策树计算肝脂肪变性和纤维化的预测概率。结果:32%的人群有肝脂肪变性的证据,以294 dB/m作为临界值。年龄、血清甘油三酯和体重指数的增加与肝脂肪变性的增加有统计学意义相关;相比之下,在多变量线性回归模型中,女性的肝脏脂肪变性值比男性低15点,具有统计学意义。在适应性套索回归中,血清LDL、吸烟、收缩压和舒张压与肝脏脂肪变性关系不大。另一方面,基于决策树分析和梯度增强模型,性别、烟草使用、代谢能量消耗和血清甘油三酯与肝纤维化的相关性最小。在决策树中,体重指数高于30和HbA1c高于5.7的人有72%的可能性发生肝脂肪变性,而体重指数低于30的人有14%的可能性发生肝脂肪变性。另一方面,体重指数超过41的人患肝纤维化的可能性为38%。结论:体重指数、血红蛋白A1c、血清甘油三酯水平、性别和年龄可以很好地预测肝脂肪变性,而体重指数、血压、血小板计数、血红蛋白A1c、血清LDL或HDL与肝纤维化高度相关,应作为VCTE/CAP转诊前的初步筛查工具。
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引用次数: 0
Effect of COVID-19 Pandemic-Related Delays in Chemoembolization on the Survival of Patients with Hepatocellular Carcinoma. COVID-19大流行相关化疗栓塞延迟对肝癌患者生存的影响
IF 2.7 4区 医学 Q2 Medicine Pub Date : 2023-01-01 DOI: 10.1155/2023/8114732
Kittipitch Bannangkoon, Keerati Hongsakul, Teeravut Tubtawee, Phurich Janjindamai

Background and aims: COVID-19 has led to potential delays in liver cancer treatment, which may have undesirable effects on the prognosis of patients. We aimed to quantify the COVID-19 pandemic impact on the survival of patients with hepatocellular carcinoma (HCC) who underwent transarterial chemoembolization (TACE).

Methods: A retrospective study was conducted in patients with HCC who underwent TACE at a tertiary care center during the prelockdown (March to July 2019) and lockdown (March to July 2020) periods. Demographic data, tumor characteristics, functional status, and vital status were collected from the hospital medical records. The endpoints were TACE interval, treatment response, and survival after TACE. Cox proportional hazards regression determined the significant preoperative factors influencing survival.

Results: Compared to prelockdown, a significant delay occurred during the lockdown in repeated TACE treatments (76.7 vs. 63.5 days, P=0.007). The trend suggested a significant decrease in patients with HCC in the repeated TACE group (-33.3%). After screening, 145 patients were included (prelockdown (n = 87), lockdown (n = 58)). There was no significant difference in the 1-month objective response rate between the prelockdown and lockdown groups (65.5% vs. 64.4%, P=1.00). During follow-up, 56 (64.4%) and 34 (58.6%) deaths occurred in the prelockdown and lockdown groups, respectively (P=0.600). Multivariate analysis revealed no association between the lockdown group and decreased survival (HR 0.88, 95% CI 0.57-1.35, P=0.555).

Conclusions: The impact of the COVID-19 pandemic on liver cancer care resulted in significant decreases and delays in repeated TACE treatments in 2020 compared to 2019. However, treatment delays did not seem to significantly impact survival.

背景与目的:COVID-19可能导致肝癌治疗延误,对患者预后产生不良影响。我们旨在量化COVID-19大流行对接受经动脉化疗栓塞(TACE)的肝细胞癌(HCC)患者生存的影响。方法:对封锁前(2019年3月至7月)和封锁期间(2020年3月至7月)在三级医疗中心接受TACE治疗的HCC患者进行回顾性研究。从医院病历中收集人口统计数据、肿瘤特征、功能状态和生命体征。终点是TACE间期、治疗反应和TACE后的生存期。Cox比例风险回归确定了术前影响生存率的重要因素。结果:与封锁前相比,重复TACE治疗在封锁期间发生了显著延迟(76.7天对63.5天,P=0.007)。这一趋势表明,重复TACE组HCC患者发生率显著下降(-33.3%)。筛选后,纳入145例患者(锁定前(n = 87),锁定前(n = 58))。封锁前组和封锁组的1个月客观有效率无显著差异(65.5%对64.4%,P=1.00)。在随访期间,封锁前组和封锁组分别发生56例(64.4%)和34例(58.6%)死亡(P=0.600)。多因素分析显示,封锁组与生存率降低无关联(HR 0.88, 95% CI 0.57-1.35, P=0.555)。结论:与2019年相比,2019冠状病毒病大流行对肝癌治疗的影响导致2020年肝癌重复TACE治疗显著减少和延迟。然而,治疗延迟似乎并没有显著影响生存。
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引用次数: 0
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Canadian Journal of Gastroenterology and Hepatology
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