Pub Date : 2025-10-07DOI: 10.1016/s2215-0366(25)00298-6
Jennifer Theule, Kylee Clayton
No Abstract
没有抽象的
{"title":"COS-P as an adjunct treatment for perinatal mental health difficulties","authors":"Jennifer Theule, Kylee Clayton","doi":"10.1016/s2215-0366(25)00298-6","DOIUrl":"https://doi.org/10.1016/s2215-0366(25)00298-6","url":null,"abstract":"No Abstract","PeriodicalId":48784,"journal":{"name":"Lancet Psychiatry","volume":"30 1","pages":""},"PeriodicalIF":64.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/s2215-0366(25)00306-2
McPhail L, Smartt C, Musyimi C, et al. Programmes for people who are homeless and have severe mental illness in low-income and middle-income countries: a systematic review. Lancet Psychiatry 2025; published online Sept 16. https://doi.org/10.1016/S2215-0366(25)00206-8—In this systematic review, table 1 has been updated to correct programme information. This correction has been made to the online version as of Oct 1, 2025, and will be made to the printed version.
{"title":"Correction to Lancet Psychiatry 2025; published online Sept 16. https://doi.org/10.1016/S2215-0366(25)00206-8","authors":"","doi":"10.1016/s2215-0366(25)00306-2","DOIUrl":"https://doi.org/10.1016/s2215-0366(25)00306-2","url":null,"abstract":"<em>McPhail L, Smartt C, Musyimi C, et al. Programmes for people who are homeless and have severe mental illness in low-income and middle-income countries: a systematic review.</em> Lancet Psychiatry <em>2025; published online Sept 16. https://doi.org/10.1016/S2215-0366(25)00206-8</em>—In this systematic review, table 1 has been updated to correct programme information. This correction has been made to the online version as of Oct 1, 2025, and will be made to the printed version.","PeriodicalId":48784,"journal":{"name":"Lancet Psychiatry","volume":"9 1","pages":""},"PeriodicalIF":64.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-30DOI: 10.1016/s2215-0366(25)00278-0
Rajesh R Tampi
No Abstract
没有抽象的
{"title":"Antipsychotics for older adults with schizophrenia","authors":"Rajesh R Tampi","doi":"10.1016/s2215-0366(25)00278-0","DOIUrl":"https://doi.org/10.1016/s2215-0366(25)00278-0","url":null,"abstract":"No Abstract","PeriodicalId":48784,"journal":{"name":"Lancet Psychiatry","volume":"31 1","pages":""},"PeriodicalIF":64.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-30DOI: 10.1016/s2215-0366(25)00268-8
Yue Wei, Vincent K C Yan, David J Castle, Caige Huang, Eunice Kehui Deng, Shek-Ming Leung, Hei Hang Edmund Yiu, Kyung Jin Lee, Simon S Y Lui, Vanessa W S Ng, Joseph F Hayes, Francisco T T Lai, Huali Wang, Eric W C Yan, Esther W Chan
Background
Older individuals (aged ≥65 years) with schizophrenia are at increased risk of treatment non-adherence due to cognitive decline and complex polypharmacy. Use of long-acting injectable (LAI) antipsychotics in this population has not been systematically investigated. We aimed to compare risk of disease relapse, all-cause mortality, and adverse events associated with LAI versus oral antipsychotics among older people with schizophrenia.
Methods
In this population-based within-subject analysis, we used territory-wide electronic health records from the Clinical Database Analysis and Reporting System of the Hong Kong Hospital Authority. Individuals diagnosed with schizophrenia (ICD-9-CM code 295) in inpatient, outpatient, or emergency department settings between Jan 1, 1993, and Dec 31, 2023, were identified, and people aged 65 years and older who were prescribed LAI or oral antipsychotics between Jan 1, 2004, and Dec 31, 2023, were considered for inclusion. Individuals with incomplete demographic information were excluded. The primary outcome was disease relapse, defined as hospital admission for schizophrenia. The secondary outcomes comprised all-cause mortality and adverse events, including cardiovascular hospital admission, extrapyramidal symptoms, acute liver injury, and acute kidney injury, which were identified using ICD-9-CM codes or laboratory tests. A self-controlled case series study using Poisson regression was conducted to compare the risk of disease relapse and adverse events between the treatment periods of LAI and oral antipsychotics. An individual-stratified Cox regression was performed for all-cause mortality. Time-varying confounders, including age, season, class of antipsychotics, COVID-19 stringency index, and concomitant treatment with antidepressants, benzodiazepines or Z-drugs, mood stabilisers, and antiparkinsonian drugs, were adjusted for. People with lived experience of schizophrenia were not involved in the design or conduct of the study.
Findings
Of 24 985 older individuals with schizophrenia, 4696 (18·8%) were prescribed LAI or oral antipsychotics. 10 655 (42·6%) of 24 985 individuals were male and 14 330 (57·4%) were female. Data on ethnicity were not available. Compared with oral antipsychotics, LAI antipsychotics were associated with statistically significantly lower risk of hospital admission for schizophrenia (incidence rate ratio [IRR] 0·71 [95% CI 0·64–0·78], p<0·0001) and all-cause mortality (hazard ratio [HR] 0·23 [95% CI 0·12–0·44], p<0·0001). No statistically significant difference was found in cardiovascular hospital admissions, acute liver injury, and acute kidney injury. LAI antipsychotics were associated with increased risk of extrapyramidal symptoms (IRR 2·17 [1·24–3·80], p=0·0068), but only with first-generation (2·86 [1·41–5·84], p=0·0038) not second-generation LAI antipsychotics.
Interpretation
In older individuals with schizophrenia, LAI antipsychotics were a
{"title":"Disease relapse, all-cause mortality, and adverse events associated with long-acting injectable antipsychotics versus oral antipsychotics in older people with schizophrenia in Hong Kong: a population-based within-subject analysis","authors":"Yue Wei, Vincent K C Yan, David J Castle, Caige Huang, Eunice Kehui Deng, Shek-Ming Leung, Hei Hang Edmund Yiu, Kyung Jin Lee, Simon S Y Lui, Vanessa W S Ng, Joseph F Hayes, Francisco T T Lai, Huali Wang, Eric W C Yan, Esther W Chan","doi":"10.1016/s2215-0366(25)00268-8","DOIUrl":"https://doi.org/10.1016/s2215-0366(25)00268-8","url":null,"abstract":"<h3>Background</h3>Older individuals (aged ≥65 years) with schizophrenia are at increased risk of treatment non-adherence due to cognitive decline and complex polypharmacy. Use of long-acting injectable (LAI) antipsychotics in this population has not been systematically investigated. We aimed to compare risk of disease relapse, all-cause mortality, and adverse events associated with LAI versus oral antipsychotics among older people with schizophrenia.<h3>Methods</h3>In this population-based within-subject analysis, we used territory-wide electronic health records from the Clinical Database Analysis and Reporting System of the Hong Kong Hospital Authority. Individuals diagnosed with schizophrenia (ICD-9-CM code 295) in inpatient, outpatient, or emergency department settings between Jan 1, 1993, and Dec 31, 2023, were identified, and people aged 65 years and older who were prescribed LAI or oral antipsychotics between Jan 1, 2004, and Dec 31, 2023, were considered for inclusion. Individuals with incomplete demographic information were excluded. The primary outcome was disease relapse, defined as hospital admission for schizophrenia. The secondary outcomes comprised all-cause mortality and adverse events, including cardiovascular hospital admission, extrapyramidal symptoms, acute liver injury, and acute kidney injury, which were identified using ICD-9-CM codes or laboratory tests. A self-controlled case series study using Poisson regression was conducted to compare the risk of disease relapse and adverse events between the treatment periods of LAI and oral antipsychotics. An individual-stratified Cox regression was performed for all-cause mortality. Time-varying confounders, including age, season, class of antipsychotics, COVID-19 stringency index, and concomitant treatment with antidepressants, benzodiazepines or Z-drugs, mood stabilisers, and antiparkinsonian drugs, were adjusted for. People with lived experience of schizophrenia were not involved in the design or conduct of the study.<h3>Findings</h3>Of 24 985 older individuals with schizophrenia, 4696 (18·8%) were prescribed LAI or oral antipsychotics. 10 655 (42·6%) of 24 985 individuals were male and 14 330 (57·4%) were female. Data on ethnicity were not available. Compared with oral antipsychotics, LAI antipsychotics were associated with statistically significantly lower risk of hospital admission for schizophrenia (incidence rate ratio [IRR] 0·71 [95% CI 0·64–0·78], p<0·0001) and all-cause mortality (hazard ratio [HR] 0·23 [95% CI 0·12–0·44], p<0·0001). No statistically significant difference was found in cardiovascular hospital admissions, acute liver injury, and acute kidney injury. LAI antipsychotics were associated with increased risk of extrapyramidal symptoms (IRR 2·17 [1·24–3·80], p=0·0068), but only with first-generation (2·86 [1·41–5·84], p=0·0038) not second-generation LAI antipsychotics.<h3>Interpretation</h3>In older individuals with schizophrenia, LAI antipsychotics were a","PeriodicalId":48784,"journal":{"name":"Lancet Psychiatry","volume":"99 1","pages":""},"PeriodicalIF":64.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-22DOI: 10.1016/s2215-0366(25)00280-9
Mohsen Rajabi, Candace J Black, Theresa S Betancourt, Rachel Calam, Fatemeh Ashrafi, Sarah L Halligan
No Abstract
没有抽象的
{"title":"Iran's mental health-care capacity and policy reforms in response to a global refugee crisis","authors":"Mohsen Rajabi, Candace J Black, Theresa S Betancourt, Rachel Calam, Fatemeh Ashrafi, Sarah L Halligan","doi":"10.1016/s2215-0366(25)00280-9","DOIUrl":"https://doi.org/10.1016/s2215-0366(25)00280-9","url":null,"abstract":"No Abstract","PeriodicalId":48784,"journal":{"name":"Lancet Psychiatry","volume":"21 1","pages":""},"PeriodicalIF":64.3,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-19DOI: 10.1016/s2215-0366(25)00302-5
Signorini G, Singh SP, Boricevic-Marsanic V, et al. Architecture and functioning of child and adolescent mental health services: a 28-country survey in Europe. Lancet Psychiatry 2017; 4: 715–24—In this Health Policy, the numbers of inpatient beds for psychiatric treatment per 100 000 young people in table 1 and paragraph 5 of page 717 have been corrected. This correction has been made as of Sept 19, 2025.
{"title":"Correction to Lancet Psychiatry 2017; 4: 715–24","authors":"","doi":"10.1016/s2215-0366(25)00302-5","DOIUrl":"https://doi.org/10.1016/s2215-0366(25)00302-5","url":null,"abstract":"<em>Signorini G, Singh SP, Boricevic-Marsanic V, et al. Architecture and functioning of child and adolescent mental health services: a 28-country survey in Europe.</em> Lancet Psychiatry <em>2017; <strong>4:</strong> 715–24</em>—In this Health Policy, the numbers of inpatient beds for psychiatric treatment per 100 000 young people in table 1 and paragraph 5 of page 717 have been corrected. This correction has been made as of Sept 19, 2025.","PeriodicalId":48784,"journal":{"name":"Lancet Psychiatry","volume":"154 1","pages":""},"PeriodicalIF":64.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145089178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-18DOI: 10.1016/s2215-0366(25)00277-9
Gerhard Gründer, Lea J Mertens, Andrea Jungaberle, Henrik Jungaberle, Moritz Spangemacher
No Abstract
没有抽象的
{"title":"Compassionate use of psilocybin for treatment-resistant depression in Germany","authors":"Gerhard Gründer, Lea J Mertens, Andrea Jungaberle, Henrik Jungaberle, Moritz Spangemacher","doi":"10.1016/s2215-0366(25)00277-9","DOIUrl":"https://doi.org/10.1016/s2215-0366(25)00277-9","url":null,"abstract":"No Abstract","PeriodicalId":48784,"journal":{"name":"Lancet Psychiatry","volume":"79 1","pages":""},"PeriodicalIF":64.3,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145083926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-16DOI: 10.1016/s2215-0366(25)00206-8
Lauren McPhail, Caroline Smartt, Christine Musyimi, Joel Agorinya, Sewit Timothewos, Fetuma Feyera, Ruth Tsigebrhan, Tigist Eshetu, Eleni Misganaw, Laura Asher, Ursula Read, Victoria Mutiso, David Ndetei, Charlotte Hanlon
Homelessness and severe mental illness are inter-related issues, the co-occurrence of which leads to poor outcomes for affected individuals. Evidence for effective interventions in high-income countries is accruing, but little is known about how to intervene in the diverse sociocultural contexts of low-income and middle-income countries (LMICs). The aim of this systematic review was to synthesise peer-reviewed and grey literature on programmes for people experiencing homelessness and severe mental illness in LMICs. We synthesised effects, programme components, and implementation strategies. We identified 80 sources describing 45 programmes across ten LMICs. Programme components spanned seven domains: service models, basic needs, health care, outreach, empowerment, community level, and macro level. Most programmes were multicomponent and included diverse delivery agents. Evaluation studies (n=21), although few in number and quality, reported clinical improvements; family reintegration ranged from 6% to 69%. Frequently reported implementation strategies included network weaving, educational meetings, and involvement of patients and family members. We identified programmes that show promise and can serve as starting points for local adaptation. This systematic review identifies common domains of programmatic interventions that are important to include in combination for future programme design, while considering local contexts and population-specific needs. Future research should prioritise rigorous evaluations, with particular emphasis on programme effects and cost benefits.
{"title":"Programmes for people who are homeless and have severe mental illness in low-income and middle-income countries: a systematic review","authors":"Lauren McPhail, Caroline Smartt, Christine Musyimi, Joel Agorinya, Sewit Timothewos, Fetuma Feyera, Ruth Tsigebrhan, Tigist Eshetu, Eleni Misganaw, Laura Asher, Ursula Read, Victoria Mutiso, David Ndetei, Charlotte Hanlon","doi":"10.1016/s2215-0366(25)00206-8","DOIUrl":"https://doi.org/10.1016/s2215-0366(25)00206-8","url":null,"abstract":"Homelessness and severe mental illness are inter-related issues, the co-occurrence of which leads to poor outcomes for affected individuals. Evidence for effective interventions in high-income countries is accruing, but little is known about how to intervene in the diverse sociocultural contexts of low-income and middle-income countries (LMICs). The aim of this systematic review was to synthesise peer-reviewed and grey literature on programmes for people experiencing homelessness and severe mental illness in LMICs. We synthesised effects, programme components, and implementation strategies. We identified 80 sources describing 45 programmes across ten LMICs. Programme components spanned seven domains: service models, basic needs, health care, outreach, empowerment, community level, and macro level. Most programmes were multicomponent and included diverse delivery agents. Evaluation studies (n=21), although few in number and quality, reported clinical improvements; family reintegration ranged from 6% to 69%. Frequently reported implementation strategies included network weaving, educational meetings, and involvement of patients and family members. We identified programmes that show promise and can serve as starting points for local adaptation. This systematic review identifies common domains of programmatic interventions that are important to include in combination for future programme design, while considering local contexts and population-specific needs. Future research should prioritise rigorous evaluations, with particular emphasis on programme effects and cost benefits.","PeriodicalId":48784,"journal":{"name":"Lancet Psychiatry","volume":"35 1","pages":""},"PeriodicalIF":64.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145072284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-16DOI: 10.1016/s2215-0366(25)00212-3
Charlotte L Lee, Min Gao, Margaret C Smith, Xue Dong, Felicity Waite, Paul N Aveyard, Carmen Piernas
<h3>Background</h3>Excess weight is common in people with severe mental illness, including schizophrenia spectrum disorders, bipolar disorder, and other non-organic psychotic disorders. Rapid weight gain often follows use of antipsychotics, but long-term weight trajectories are unclear. We aimed to compare 15-year weight trajectories and assess the incidence of weight management advice and referrals among people with and without severe mental illness.<h3>Methods</h3>In this retrospective, matched cohort study, we used the Clinical Practice Research Datalink Aurum to identify people aged 18–65 years registered at 1454 primary care practices in England (UK) between Jan 1, 1998, and Oct 31, 2020. 12 people with lived experience of severe mental illness informed the research objectives and study design. Registered individuals who had been diagnosed with severe mental illness (ICD-10 F20–39) were eligible. Each person with severe mental illness was frequency-matched with up to four people without severe mental illness on age, sex, practice, and calendar year. The first coprimary outcome was change in weight (kg), as per all recorded weight measures in the electronic health record. The second coprimary outcome was the incidence of advice and referral to weight management services. We estimated weight trajectories using hierarchical mixed-effects linear regression models and the incidence of advice and referrals using zero-inflated Poisson regression models.<h3>Findings</h3>We included 113 904 individuals (mean age 39·17 years [SD 12·38]), of whom 51 062 (44·8%) were male and 62 842 (55·2%) were female; 90 620 (79·6%) self-identified as White, 7430 (6·5%) as Black, 12 288 (10·8%) as Asian, 1983 (1·7%) as mixed, and 1583 (1·4%) as other. 90 879 (79·8%) individuals did not have severe mental illness; 23 025 (20·2%) individuals had received a diagnosis of severe mental illness: 11 039 (47·9%) had a schizophrenia spectrum disorder, 11 942 (51·9%) had bipolar disorder, and 44 (0·2%) had other psychoses. Weight in people with severe mental illness increased by 2·10 kg (95% CI 1·98–2·22; p<0·0001) at year 1 and by 5·55 kg (5·24–5·86; p<0·0001) at year 15, compared with 0·58 kg (0·51–0·65; p<0·0001) at year 1 and 1·62 kg (1·42–1·82; p<0·0001) at year 15 in people without severe mental illness. After adjusting for age, sex, race and ethnicity, socioeconomic status, alcohol consumption status, smoking status, and BMI, people with severe mental illness and a BMI of 25 kg/m<sup>2</sup> or higher were 10% more likely to receive weight advice than people without severe mental illness (incidence rate ratio 1·10 [95% CI 1·07–1·13]; 8·51 × 10<sup>−10</sup>). There were no differences in the rates of referral to weight management programmes between people with and without severe mental illness.<h3>Interpretation</h3>People with severe mental illness are more likely to gain weight rapidly after diagnosis than the general population, with effects lasting up to
背景体重过重在严重精神疾病患者中很常见，包括精神分裂症谱系障碍、双相情感障碍和其他非器质性精神障碍。服用抗精神病药物后，体重通常会迅速增加，但长期的体重轨迹尚不清楚。我们的目的是比较15年的体重轨迹，并评估有和没有严重精神疾病的人的体重管理建议和转诊的发生率。方法在这项回顾性、匹配队列研究中，我们使用临床实践研究数据链Aurum来识别1998年1月1日至2020年10月31日期间在英国1454个初级保健诊所登记的18-65岁人群。12名有严重精神疾病生活经历的人告知了研究目标和研究设计。被诊断患有严重精神疾病（ICD-10 F20-39）的登记个体符合条件。每个患有严重精神疾病的人与多达四名没有严重精神疾病的人在年龄、性别、实践和日历年上进行频繁匹配。第一个主要结局是体重（kg）的变化，根据电子健康记录中记录的所有体重测量值。第二个主要结果是体重管理服务的建议和转诊的发生率。我们使用分层混合效应线性回归模型估计体重轨迹，使用零膨胀泊松回归模型估计建议和转诊的发生率。结果纳入113 904例个体（平均年龄39.17岁[SD 12.38]），其中男性51 062例（44.8%），女性62 842例（55.2%）；90620人（79.6%）自认为是白人，7430人（6.5%）自认为是黑人，12288人（10.8%）自认为是亚洲人，1983年（1.7%）自认为是混血儿，1583人（1.4%）自认为是其他。90879人（79.8%）无严重精神疾病；23 025人（20.2%）被诊断患有严重精神疾病：11 039人（47.9%）患有精神分裂症谱系障碍，11 1942人（51.9%）患有双相情感障碍，44人（0.2%）患有其他精神病。严重精神疾病患者的体重在第1年增加了2.10 kg (95% CI 1.98 - 2.22; p< 0.0001)，在第15年增加了5.55 kg (5.24 - 5.86; p< 0.0001)，而非严重精神疾病患者的体重在第1年增加了0.58 kg （0.51 - 0.65; p< 0.0001）和1.62 kg（1.42 - 1·82;p< 0.0001）。在调整了年龄、性别、种族和民族、社会经济地位、饮酒状况、吸烟状况和BMI等因素后，患有严重精神疾病且BMI为25 kg/m2或更高的人比没有严重精神疾病的人接受体重建议的可能性高10%（发病率比为1.10 [95% CI 1.07 - 1.13]; 8.51 × 10−10）。在有和没有严重精神疾病的人之间，转介到体重管理项目的比率没有差异。与一般人群相比，患有严重精神疾病的人在诊断后更有可能迅速增加体重，其影响可持续长达15年。尽管经常建议减肥，但体重增加与转介到体重管理服务的比率并不匹配。早期干预对于减少超重和相关的心脏代谢风险至关重要。
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