The Lancet Diabetes & Endocrinology最新文献

{"title":"Continuous ketone monitoring for people with diabetes: international expert recommendations on the application of a new technology","authors":"Ketan Dhatariya, Richard M Bergenstal, Mohammed Al-Sofiani, Anastasia Albanese-O’Neill, Tadej Battelino, Kelly Close, Christophe De Block, Sanjoy Dutta, Rodolfo J Galindo, Amin GhavamiNejad, Ahmad Haidar, Julie Heverly, Davida Kruger, Lori M Laffel, Julianne Lally, David M Maahs, Claudio Maffeis, Chantal Mathieu, Eden Miller, Medha Munshi, Rimei Nishimura, Kirsten Nørgaard, Tal Oron, David N O’Neal, Monica Oxenreiter, Bruce A Perkins, Moshe Phillip, Eric Renard, Jonathan Rosen, Mauro Scharf, Jennifer Sherr, Carol Wysham, Thomas Danne","doi":"10.1016/s2213-8587(25)00331-6","DOIUrl":"https://doi.org/10.1016/s2213-8587(25)00331-6","url":null,"abstract":"The ability to reduce the risk of developing diabetic ketoacidosis (DKA) remains a major care gap for people with diabetes, particularly those on intensive insulin therapy. The anticipated availability of continuous ketone monitoring (CKM) has the potential to reduce the risk of developing DKA, one of the most life-threatening acute complications of type 1 and type 2 diabetes. International clinical guidelines have established ketone thresholds for suspected and confirmed diagnoses of DKA, based on use of point-of-care testing, as part of a triad of markers with allied thresholds for hyperglycaemia and acidosis. The increasing occurrence of euglycemic DKA, with glucose concentrations below established diagnostic thresholds, makes the availability and use of CKM technology an important addition to the diabetes management toolkit. CKM data could alert the user when the risk of acute DKA is high on sick days in addition to signalling that individuals might be predicted to be at greater overall risk of future DKA on the basis of the distribution and degree of ketone measures in daily life. If widespread use of CKM devices is to be safe and effective in reducing the occurrence of DKA, it is important to establish clear ketone thresholds which notify CKM users when action on their part is required. In defining these thresholds and actions, it was important to ensure that the CKM user is not exposed to avoidable anxiety or suffers alarm fatigue, thus adding to the burden of living with diabetes. In the absence of substantial evidence that can identify appropriate ketone thresholds for CKM use, a panel of international experts in the management of DKA was convened with the aim of developing a number of objective, practical recommendations on how this novel diabetes technology could improve outcomes for individuals at risk of DKA, the results of which we report in this Personal View. These recommendations have been endorsed by the International Society for Pediatric and Adolescent Diabetes (ISPAD).","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"15 1","pages":"82-92"},"PeriodicalIF":44.5,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145731078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic risk-targeted islet autoantibody screening for presymptomatic type 1 diabetes in adults","authors":"N J Thomas, A Long, K Gillespie, D P Fraser, A Hill, L Ferrat, C Evans-Molina, T McDonald, R Nice, A Jones, A T Hattersley, W A Hagopian, R A Oram","doi":"10.1016/s2213-8587(25)00318-3","DOIUrl":"https://doi.org/10.1016/s2213-8587(25)00318-3","url":null,"abstract":"","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"66 1","pages":"11-13"},"PeriodicalIF":44.5,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145731074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social learning theories and metabolic health: the centenary of Bandura's birth","authors":"Marta Koch, Daniel McQueen, Lorena Terclavers, Naveed Sattar","doi":"10.1016/s2213-8587(25)00392-4","DOIUrl":"https://doi.org/10.1016/s2213-8587(25)00392-4","url":null,"abstract":"","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"29 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145689536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The urgent need for a diabetes data rights charter.","authors":"Laura Downey, Hanne Ballhausen, Louise Hatherall, Holly Hayes, Shane O'Donnell","doi":"10.1016/S2213-8587(25)00291-8","DOIUrl":"10.1016/S2213-8587(25)00291-8","url":null,"abstract":"","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":" ","pages":"999"},"PeriodicalIF":41.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145369123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in research and care of familial hypercholesterolaemia.","authors":"Raul D Santos, Samuel S Gidding, Mafalda Bourbon, Iulia Iatan, Mariko Harada-Shiba, Frederick J Raal, Antonio J Vallejo-Vaz, Albert Wiegman, Gerald F Watts","doi":"10.1016/S2213-8587(25)00286-4","DOIUrl":"10.1016/S2213-8587(25)00286-4","url":null,"abstract":"<p><p>Heterozygous familial hypercholesterolaemia is a common, autosomal semi-dominant condition characterised by elevation of LDL cholesterol from birth and early onset of atherosclerotic cardiovascular disease. With major advances in knowledge about the disease, familial hypercholesterolaemia has become an exemplar for the practice of precision and personalised medicine. Beyond genetics, developments in clinical risk prediction algorithms and cardiovascular imaging have enabled more accurate risk stratification of patients. Early initiation of cholesterol-lowering therapies can reduce the progression of atherosclerosis and prevent cardiovascular events. Newer treatments offer the possibility of normalising plasma LDL cholesterol concentrations even in homozygous familial hypercholesterolaemia, the most severe form of the condition. Despite these advances, familial hypercholesterolaemia is still inadequately diagnosed and undertreated, with many affected people remaining at high risk of early cardiovascular disease. The application of implementation science to expanding knowledge of familial hypercholesterolaemia has enabled the development and design of potentially more effective models of care. This Review discusses the contemporary knowledge of familial hypercholesterolaemia and its unmet clinical needs.</p>","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":" ","pages":"1054-1071"},"PeriodicalIF":41.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145370462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity legally recognised as a chronic disease in Italy.","authors":"Maurizio Bifulco, Cristina Pagano, Erika Di Zazzo","doi":"10.1016/S2213-8587(25)00326-2","DOIUrl":"10.1016/S2213-8587(25)00326-2","url":null,"abstract":"","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":" ","pages":"1001-1002"},"PeriodicalIF":41.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145370457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to Lancet Diabetes Endocrinol 2025; 13: 909-10.","authors":"","doi":"10.1016/S2213-8587(25)00329-8","DOIUrl":"10.1016/S2213-8587(25)00329-8","url":null,"abstract":"","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":" ","pages":"e15"},"PeriodicalIF":41.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145369134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes and cancer in the age of multimorbidity","authors":"","doi":"10.1016/s2213-8587(25)00365-1","DOIUrl":"https://doi.org/10.1016/s2213-8587(25)00365-1","url":null,"abstract":"No Abstract","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"4 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145609163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycaemic control and pregnancy outcomes with real-time continuous glucose monitoring in gestational diabetes (GRACE): an open-label, multicentre, multinational, randomised controlled trial","authors":"Tina Linder, Iris Dressler-Steinbach, Silke Wegener, Karen Schellong, Saskia Schmidt, Daniel Eppel, Cécile Monod, Florian Heinzl, Katharina Redling, Bettina Winzeler, Beatrice Mosimann, Friederike Weschenfelder, Tanja Groten, Martina Mittlböck, Johan Jendle, Wolfgang Henrich, Micaela Morettini, Latife Bozkurt, Andrea Tura, Christian Göbl, Grammata Kotzaeridi, Ingeborg Brandl, Anja Catic, Ingo Rosicky, Theresa Grill, Veronika Zehetgruber, Daniela Dittrich, Hanka Sahbegovic, Karen Weißhaupt, Luca Pfeiffer, Amelie Berg, Max Hackelöer, Vera Seidel-Eder, Petra Weid, Yvonne Heimann, Victoria Trautmann, Mirka Basten, Christina Granado, Agnese Piersanti, Michael Roden, Markus Vomhof, Gregory Greiner, Andrea Icks, Evelyn Huhn, Irene Hösli, Christian Singer","doi":"10.1016/s2213-8587(25)00288-8","DOIUrl":"https://doi.org/10.1016/s2213-8587(25)00288-8","url":null,"abstract":"","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"114 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145592845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does continuous glucose monitoring deliver in gestational diabetes?","authors":"Lene Ringholm","doi":"10.1016/s2213-8587(25)00297-9","DOIUrl":"https://doi.org/10.1016/s2213-8587(25)00297-9","url":null,"abstract":"","PeriodicalId":48790,"journal":{"name":"The Lancet Diabetes & Endocrinology","volume":"188 1","pages":""},"PeriodicalIF":44.5,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145592846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}