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Enrollment in a Behavioral Health Program Positively Impacts 2-Year Cumulative Survival Rates in Osteochondral Allograft Transplant Patients. 参加行为健康项目对骨软骨异体移植患者的 2 年累积存活率有积极影响。
IF 1.6 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-09-05 DOI: 10.1055/s-0044-1790252
Jonathan Williams, Kylee Rucinski, Renee Stucky, James P Stannard, Cory R Crecelius, Aaron M Stoker, Clayton W Nuelle, James L Cook

Emerging evidence suggests that patients' behavioral health may influence outcomes after osteochondral allograft transplantation (OCAT). A comprehensive behavioral health program (BHP) including preoperative screening and education, and postoperative counseling and support, led by a health behavior psychologist was implemented for patients considering OCAT. We hypothesized that patients undergoing knee OCAT and enrolled in the BHP would have a significantly higher 2-year graft survival rate than those not enrolled. Prospectively collected data for patients undergoing knee OCAT enrolled in the lifelong outcomes registry were analyzed. Based on the timing of implementation of a comprehensive BHP to provide preoperative screening and education followed by postoperative counseling and support, BHP and no-BHP cohorts were compared. Treatment failure was defined as the need for either OCAT revision surgery or knee arthroplasty. The Kaplan-Meier method using log-rank tests compared cumulative survival rates. Multivariable Cox regression analysis was used to determine the effects of confounding variables on the influence of BHP enrollment on graft survival. A total of 301 patients were analyzed (no-BHP = 220 and BHP = 81). At 2-year follow-up, a significantly lower cumulative graft survival rate was observed for patients not enrolled in the BHP (68.2 vs. 91.4%; p = 0.00347). Adjusting for sex, age, body mass index, tobacco use, tibiofemoral bipolar OCAT type surgery, and nonadherence, patients not enrolled in the BHP were 2.8 times more likely to experience OCAT treatment failure by 2 years after primary OCAT compared with patients in the BHP (95% confidence interval, 1.02-4.98; p = 0.01). A comprehensive BHP contributes to significant improvements in 2-year graft survival rates following OCAT in the knee. Preoperative mental and behavioral health screening and support for shared decision-making regarding treatment options, in conjunction with patient and caregiver education and assistance through integrated health care team engagement, are beneficial to patients pursuing complex joint preservation surgeries. Level of evidence is 2, prospective cohort study.

新的证据表明,患者的行为健康可能会影响骨软骨异体移植(OCAT)后的疗效。我们为考虑接受 OCAT 的患者实施了一项全面的行为健康计划(BHP),包括术前筛查和教育以及术后咨询和支持,由一名健康行为心理学家负责。我们假设,接受膝关节OCAT手术并加入BHP的患者的2年移植物存活率将明显高于未加入BHP的患者。我们分析了前瞻性收集到的膝关节OCAT患者终身结果登记数据。根据提供术前筛查和教育以及术后咨询和支持的综合必赢国际注册的实施时间,比较了必赢国际注册队列和无必赢国际注册队列。治疗失败的定义是需要进行OCAT翻修手术或膝关节置换术。采用对数秩检验的 Kaplan-Meier 法比较了累积存活率。多变量 Cox 回归分析用于确定混杂变量对 BHP 注册对移植物存活率的影响。共分析了 301 例患者(无 BHP = 220 例,BHP = 81 例)。在 2 年的随访中,未加入 BHP 的患者的累计移植物存活率明显较低(68.2% vs. 91.4%;P = 0.00347)。在对性别、年龄、体重指数、吸烟、胫骨股骨双极OCAT类型手术和不依从性进行调整后,未参加必赢国际注册的患者在初次OCAT治疗后2年内出现OCAT治疗失败的可能性是参加必赢国际注册患者的2.8倍(95%置信区间,1.02-4.98;p = 0.01)。综合必赢国际注册有助于显著提高膝关节 OCAT 术后 2 年的移植物存活率。术前心理和行为健康筛查以及治疗方案共同决策支持,再加上患者和护理人员的教育以及综合医疗团队的协助,对接受复杂关节保留手术的患者大有裨益。证据等级为2级,前瞻性队列研究。
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引用次数: 0
Computer Patient-Specific 3D Modeling and Custom-Made Guides for Revision ACL Surgery. 用于前交叉韧带翻修手术的特定患者计算机三维建模和定制指南。
IF 1.6 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-09-01 Epub Date: 2024-04-27 DOI: 10.1055/a-2315-7873
Armando Del Prete, Piero Franco, Matteo Innocenti, Fabrizio Matassi, Filippo Leggieri, Rosario Jr Sagliocco, Roberto Civinini

Revision anterior cruciate ligament reconstruction (ACLR) is a challenging surgery occurring in 3 to 24% of primary reconstructions. A meticulous planning to study the precise size and location of both femoral and tibial bone tunnels is mandatory. The aim of the study was to evaluate the intra- and interoperator differences in the decision-making process between experienced surgeons after they were asked to make preoperative planning for ACL revision reconstruction with the use of both the computed tomography (CT) scan and a three-dimensional (3D)-printed model of the knee. Data collected from 23 consecutive patients undergoing revision of ACLR for graft failure at a single institute between September 2018 and February 2020 were prospectively reviewed. The double-blinded collected data were presented to three board-certificate attending surgeons. Surgeons were asked to decide whether to perform one-stage or two-stage revision ACLR based on the evaluation of the CT scan images and the 3D-printed custom-made models at two different rounds, T0 and T1, respectively, 7 days apart one from the other. Interoperator consensus following technical mistake was 52% at T0 and 56% at T1 using the CT scans, meanwhile concordance was 95% at T0 and 94% at T1 using the 3D models. Concordance between surgeons following new knee injury was 66% at T0 and 70% at T1 using CT scans, while concordance was 96% both at T0 and T1 using 3D models. Intraoperative variability using 3D models was extremely low: concordance at T0 and T1 was 98%. McNemar test showed a statistical significance in the use of 3D model for preoperative planning (p < 0.005). 3D-printed model reliability resulted to be higher compared with CT as intraoperator surgery technique selection was not modified throughout time from T0 to T1 (p < 0.005). The use of 3D-printed models had the most impact when evaluating femoral and tibial tunnels, resulting to be a useful instrument during preoperative planning of revision ACLR between attending surgeons with medium-high workflow.

简介:前交叉韧带重建(ACLR)翻修手术是一项具有挑战性的手术,占初次重建手术的 3-24%。必须对股骨和胫骨隧道的精确尺寸和位置进行细致的规划研究。该研究旨在评估经验丰富的外科医生在利用 CT 扫描和膝关节 3D 打印模型进行前交叉韧带翻修重建的术前规划后,其决策过程中的术内和术者间差异:前瞻性回顾了2018年9月至2020年2月期间在一家研究所因移植物失败而接受前交叉韧带翻修重建术的23名连续患者的数据。收集到的双盲数据提交给了三位获得委员会认证的主治外科医生。外科医生被要求根据 CT 扫描图像和 3D 打印定制模型的评估结果,分别在 T0 和 T1 两轮不同的时间段(相隔七天)决定进行一期或二期前交叉韧带翻修手术:结果:使用 CT 扫描时,技术失误后医生间的一致性在 T0 和 T1 分别为 52% 和 56%;而使用 3D 模型时,一致性在 T0 和 T1 分别为 95% 和 94%。外科医生在膝关节新伤后使用 CT 扫描时,T0 和 T1 的一致性分别为 66% 和 70%,而使用三维模型时,T0 和 T1 的一致性均为 96%。使用三维模型的术中变异性极低:T0 和 T1 的一致性为 98%。McNamar 检验显示,使用三维模型进行术前规划具有统计学意义(P < 0.005)。与 CT 相比,3D 打印模型的可靠性更高,因为从 T0 到 T1 的整个时间段内,术者的手术技术选择都没有改变(p < 0.005):结论:在评估股骨和胫骨隧道时,3D 打印模型的使用影响最大,因此是工作流程中等偏上的主治医生在翻修 ACLR 术前规划中的有用工具。
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引用次数: 0
Isolated, Proximal Tibiofibular Injuries in Athletic Patients: A Critical Analysis Review. 运动员胫腓骨近端孤立性损伤:批判性分析综述。
IF 1.6 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-09-01 Epub Date: 2024-04-27 DOI: 10.1055/a-2315-7691
Derrick M Knapik, Varun Gopinatth, Garrett R Jackson, Robert F LaPrade, Jorge Chahla, Robert H Brophy, Matthew J Matava, Matthew V Smith

While infrequently reported, isolated injuries to the proximal tibiofibular (TF) joint primarily occur in young, athletic patients participating in sporting activities requiring explosive, high-impact movements, increasing the risk for potential twisting injuries, especially across a hyperflexed knee. The proximal TF joint is stabilized by bony, muscular and ligamentous structures, including both the anterior and posterior proximal TF complexes, with the anterior complex providing more robust stability. Proximal TF injuries frequently involve anterior and lateral displacement of the proximal fibula relative to its native articulation with the tibia. Proper diagnosis is dependent on careful and meticulous history and physical examination, as missed injuries are common, leading to the potential for continued pain, weakness and disability, especially in athletic patients. While spontaneous joint reduction has been reported, injuries may require formal closed reduction, with irreducible and chronic injuries requiring open reduction and stabilization, with recent investigations reporting satisfactory outcomes following anatomic reconstruction of the proximal TF ligament.

胫腓骨近端(TF)关节的孤立损伤虽然鲜有报道,但主要发生在参与需要爆发力、高冲击力运动的体育活动的年轻运动员身上,这增加了潜在扭转损伤的风险,尤其是在膝关节过度屈曲的情况下。胫腓骨近端关节由骨、肌肉和韧带结构稳定,包括胫腓骨近端前复合体和后复合体,其中前复合体提供更强的稳定性。胫腓骨近端损伤经常涉及腓骨近端相对于其与胫骨的原生关节的前侧和外侧移位。正确的诊断有赖于认真细致的病史和体格检查,因为漏诊很常见,可能导致持续疼痛、虚弱和残疾,尤其是在运动员患者中。虽然有自发关节复位的报道,但损伤可能需要正式的闭合复位,不可复位的慢性损伤需要开放复位和稳定,最近的研究报告显示,近端 TF 韧带解剖重建后的疗效令人满意。
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引用次数: 0
Short-term Comparison of Survivorship and Functional Outcomes for Metaphyseal Cones with Short and Long Stems in Revision Total Knee Arthroplasty. 在翻修全膝关节置换术中使用带短柄和长柄的骺锥体的存活率和功能效果的短期比较。
IF 1.6 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-09-01 Epub Date: 2024-04-27 DOI: 10.1055/a-2315-7778
Nicolas S Piuzzi, Emily L Hampp, Sarah Shi, Manoshi Bhowmik-Stoker, Nickelas Huffman, Kevin M Denehy, David C Markel, Daniel D Li, Michael A Mont

Printed porous titanium metaphyseal cones have become a mainstay for managing bone loss in revision total knee arthroplasty (rTKA). A short or long stem is routinely used when implanting a cone to augment fixation and offload stresses. This retrospective analysis compared the short-term survivorships and functional outcomes for use of a short or long stem with a metaphyseal cone.A total of 179 cases using metaphyseal cones and stems with median follow-up of 1.95 years (interquartile range, 1.00-2.14) were compared based on stem type. There were 55 cases with long stem(s) and 124 cases with short stem(s). Cases with both long and short stems were excluded. Demographics, Kaplan-Meier survivorships, and preoperative and 1-year postoperative patient-reported outcome measures (PROMs; 2011 Knee Society Score [KSS] objective knee score, function, and satisfaction scores; EuroQol five-dimension scale; and Short Form Survey Physical Component Summary and Mental Component Summary scores) were compared using t-tests with a significance level of α = 0.05. There were no significant differences in body mass index (mean ± standard deviation) or sex (men [%]) between the short and long stem cohorts (32.3 ± 5.3, 36.3% and 31.5 ± 5.5, 38.2%, respectively; p > 0.05). Patients who had short stems were younger (65.9 ± 8.8 vs. 69.0 ± 9.4, p = 0.0323).Revision-free survivorship for the femoral or tibial component was 100% for long stems and 98.2% for short stems at 1 and 2 years, respectively (log-rank p = 0.6330). The two revisions in the short group were for infection, thus the survivorship for aseptic loosening was 100% at 2 years for both cohorts. There were no significant differences in preoperative or postoperative PROMs.This study demonstrated that highly porous printed metaphyseal cones provided rTKA with excellent early survivorship and similar PROMs whether a short or long stem was used. Additional studies will be needed to discern longer term differences.

简介:印刷多孔钛骺锥体已成为翻修全膝关节置换术(rTKA)中控制骨质流失的主要方法。在植入锥体时,通常会使用长短柄来增强固定和卸载应力。这项回顾性分析比较了使用骺锥体的短骨柄或长骨柄的短期存活率和功能结果:根据骨干类型比较了179个使用骺锥和骨干的病例,中位随访时间为1.95年(四分位间范围为1.00至2.14年)。其中 55 例使用长柄,124 例使用短柄。同时具有长茎和短茎的病例被排除在外。采用t检验比较了人口统计学、Kaplan-Meier存活率、术前和术后一年的患者报告结果指标(PROMs)[2011年膝关节协会评分(KSS)客观膝关节评分、功能和满意度评分;EuroQol五维量表(EQ5D);以及简表调查(SF12)身体成分汇总(PCS)和精神成分汇总(MCS)评分],显著性水平为α=0.05。在体重指数(BMI)(平均值±标度)或性别[男性(%)]方面,短茎组和长茎组之间没有明显差异(分别为32.3±5.3,36.3%和31.5±5.5,38.2%;P>0.05)。使用短茎的患者更年轻(65.9 ± 8.8 vs. 69.0 ± 9.4,P=0.0323):结果:一年和两年后,股骨或胫骨组件的无翻修存活率长柄组为100%,短柄组为98.2%(log-Rank P=0.6330)。短柄组的两次翻修都是因为感染,因此两组患者两年后的无菌性松动存活率均为100%。术前和术后PROMs无明显差异:这项研究表明,无论使用长茎还是短茎,高多孔印刷骺锥体都能为rTKA提供良好的早期存活率和相似的PROM。还需要进行更多研究,以确定长期差异。
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引用次数: 0
Patient Demographic Factors Impact KOOS JR Response Rates for Total Knee Arthroplasty Patients. 患者人口统计学因素对全膝关节置换术患者 KOOS JR 响应率的影响
IF 1.6 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-09-01 Epub Date: 2024-05-22 DOI: 10.1055/s-0044-1787055
Yixuan Tong, Vinaya Rajahraman, Rajan Gupta, Ran Schwarzkopf, Joshua C Rozell

The Knee injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS JR) is a validated patient-reported measure for assessing pain and function following total knee arthroplasty (TKA). This study investigates how patient demographic factors (i.e., age, sex, and race) correlate with KOOS JR response rates. This was a retrospective cohort study of adult, English-speaking patients who underwent primary TKA between 2017 and 2023 at an academic institution. KOOS JR completion status-complete or incomplete-was recorded within 90 days postoperatively. Standard statistical analyses were performed to assess KOOS JR completion against demographic factors. Among 2,883 total patients, 70.2% had complete and 29.8% had incomplete KOOS JR questionnaires. Complete status (all p < 0.01) was associated with patients aged 60 to 79 (71.8%), white race (77.6%), Medicare (81.7%), marriage (76.8%), and the highest income quartile (75.7%). Incomplete status (all p < 0.001) was associated with patients aged 18 to 59 (64.4%), Medicaid (82.4%), and lower income quartiles (41.6% first quartile, 36.8% third quartile). Multiple patient demographic factors may affect KOOS JR completion rates; patients who are older, white, and of higher socioeconomic status are more likely to participate. Addressing underrepresented groups is important to improve the utility and generalizability of the KOOS JR.

膝关节损伤和骨关节炎关节置换术结果评分(KOOS JR)是一项经过验证的患者报告测量方法,用于评估全膝关节置换术(TKA)后的疼痛和功能。本研究调查了患者人口统计学因素(即年龄、性别和种族)与 KOOS JR 响应率的相关性。这是一项回顾性队列研究,研究对象是 2017 年至 2023 年期间在一家学术机构接受初级 TKA 手术的讲英语的成年患者。术后 90 天内记录了 KOOS JR 的完成状态--完成或未完成。对KOOS JR完成情况与人口统计学因素进行了标准统计分析。在2883名患者中,70.2%的患者填写了完整的KOOS JR问卷,29.8%的患者填写了不完整的KOOS JR问卷。完成情况(所有 p
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引用次数: 0
Specific Preoperative Factors Increase Manipulations under Anesthesia Following Primary TKA. 特定的术前因素会增加初级 TKA 术后麻醉下的操作。
IF 1.6 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-09-01 Epub Date: 2024-04-27 DOI: 10.1055/a-2315-7955
Anson G Bautista, Nicholas L Kolodychuk, Jeremy S Frederick, Michael B Held, H John Cooper, Roshan P Shah, Jeffrey A Geller

Arthrofibrosis following primary total knee arthroplasty (TKA) can result in pain and limit postoperative range of motion (ROM), jeopardizing clinical outcomes and patient satisfaction. This study aims to identify preoperative risk factors associated with necessitating a manipulation under anesthesia (MUA) following primary TKA.We retrospectively reviewed 950 cases of consecutive primary TKAs performed at one institution by three arthroplasty surgeons between May 2017 and May 2019. Recorded preoperative variables included smoking status, race, preoperative ROM, presence of effusion or positive anterior drawer, and medical comorbidities. Demographic characteristics were compared with Student's t-tests or chi-square tests as appropriate. For each preoperative factor, we obtained an odds ratio (OR) for MUA risk using multivariate logistic regression.Twenty (2.3%) patients underwent MUA following their index primary TKA surgery. History of ipsilateral knee surgery (OR: 2.727, p = 0.047) and diagnosed hypertension (OR: 4.764, p = 0.016) were identified as risk factors associated with significantly increased risk of MUA. The greater the preoperative ROM, the higher likelihood needed of MUA (OR: 1.031, p = 0.034).Patients who had diagnosed hypertension or a history of prior ipsilateral knee surgery were associated with increased risk of necessitating an MUA following primary TKA. Additionally, a greater total arc of motion preoperatively increased the odds of needing MUA.Level III of evidence was present.

背景 原发性全膝关节置换术(TKA)后关节纤维化会导致疼痛并限制术后活动范围(ROM),从而影响临床效果和患者满意度。本研究旨在确定初级 TKA 术后需要麻醉下操作 (MUA) 的相关术前风险因素。方法 我们回顾性地审查了 2017 年 5 月至 2019 年 5 月期间由三位关节成形术外科医生在一家机构进行的 950 例连续原发性 TKA 病例。记录的术前变量包括吸烟状况、种族、术前 ROM、有无渗液或前抽屉阳性以及合并症。人口统计学特征酌情采用学生 t 检验或卡方检验进行比较。针对每个术前因素,我们使用多元逻辑回归法得出了MUA风险的几率比率。结果 20 名(2.3%)患者在接受了指数初级 TKA 手术后接受了 MUA。同侧膝关节手术史(几率比 [OR]:2.727,P=0.047)和确诊高血压(OR:4.764,P=0.016)被确定为与 MUA 风险显著增加相关的风险因素。术前活动范围越大,发生 MUA 的可能性越高(OR:1.031,P=0.034)。结论 诊断出患有高血压或之前有过同侧膝关节手术史的患者在初次 TKA 术后需要进行 MUA 的风险较高。此外,术前总运动弧度越大,需要 MUA 的几率越高。
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引用次数: 0
Relationship between Kinesiophobia and Dynamic Postural Stability after Anterior Cruciate Ligament Reconstruction: A Prospective Cohort Study. 前十字韧带重建术后运动恐惧与动态姿势稳定性之间的关系:一项前瞻性队列研究。
IF 1.6 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-09-01 Epub Date: 2024-04-27 DOI: 10.1055/a-2315-8034
Derrick M Knapik, Aguri Kamitani, Matthew V Smith, John Motley, Amanda K Haas, Matthew J Matava, Rick W Wright, Robert H Brophy

Anterior cruciate ligament (ACL) injuries in young, active patients generally require ACL reconstruction (ACLR) to restore mechanical and postural stability. The fear of movement or reinjury (kinesiophobia) has become increasingly recognized in the post-ACLR population; however, the association between restoration of postural stability and kinesiophobia remains largely unknown. The purpose of this study was to investigate changes in mean Tampa Scale of Kinesiophobia-11 (TSK-11), dynamic motion analysis (DMA) scores, and time on the testing platform, as well as any correlation between TSK-11 and mean overall and individual translational and rotational DMA scores during the first 12 months following ACLR. Cohort study. Patients undergoing ACLR were prospectively enrolled and dynamic postural stability and kinesiophobia based on the TSK-11 were collected within 2 days prior to surgery and at 6 and 12 months following ACLR. Dynamic postural stability was quantified by calculating a DMA score, with score calculated in three translational (anterior/posterior [AP], up/down [UD], medial/lateral [ML]) and three rotational (left/right [LR], flexion/extension, and internal/external rotation) independent planes of motions. Correlations between DMA and TSK-11 scores at each time point were analyzed. A total of 25 patients meeting inclusion criteria were analyzed. Mean overall DMA and TSK-11 scores increased with each successive testing interval. At 6-month follow-up, a weakly positive association between TSK-11 and DMA scores was appreciated based on overall DMA, AP, UD, ML, and LR. At 12 months, a moderately positive correlation was appreciated between TSK-11 and the translational, but not rotational, planes of motion. Following ACLR, lower level of kinesiophobia were found to be moderately associated with improved dynamic stability, especially in the translation planes of motion.

导言:年轻好动的前十字韧带(ACL)损伤患者通常需要进行前十字韧带重建(ACLR),以恢复机械和姿势的稳定性。在 ACLR 术后人群中,对运动或再损伤的恐惧(运动恐惧症)已被越来越多的人所认识,但姿势稳定性的恢复与运动恐惧症之间的关系在很大程度上仍不为人所知。本研究的目的是调查前交叉韧带置换术后 12 个月内 TSK-11 平均值、DMA 评分和在测试平台上的时间的变化,以及 TSK-11 与整体和单个平移和旋转 DMA 平均值之间的相关性:队列研究 方法:前交叉韧带置换术患者均接受了前瞻性研究,并在术前 2 天内以及术后 6 个月和 12 个月收集了动态姿势稳定性和基于坦帕运动恐惧量表-11(TSK-11)的运动恐惧。动态姿势稳定性是通过计算动态运动分析(DMA)得分来量化的,在三个平移平面(前/后[AP]、上/下[UD]、内/外侧[ML])和三个旋转平面(左/右[LR]、屈/伸[FE]和内/外旋[Rot])计算得分。对每个时间点的 DMA 和 TSK-11 评分之间的相关性进行了分析:结果:共对 25 名符合纳入标准的患者进行了分析。DMA和TSK-11的平均总分随着每次测试间隔的延长而增加。在 6 个月的随访中,根据总体 DMA、AP、UD、ML 和 LR,TSK-11 和 DMA 分数之间呈弱正相关。在 12 个月的随访中,TSK-11 与平移运动平面(而非旋转运动平面)呈中度正相关:结论:前交叉韧带置换术后,较低程度的运动恐惧与动态稳定性的改善有一定关系,尤其是在平移运动平面上。
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引用次数: 0
Cell-Mediated Immune Responses May Play Roles in Osteochondral Allograft Transplantation Osteointegration Failures. 细胞介导的免疫反应可能在骨软骨异体移植骨整合失败中发挥作用
IF 1.6 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-09-01 Epub Date: 2024-05-16 DOI: 10.1055/s-0044-1787058
Josephine Luk, Chantelle C Bozynski, Jonathan Williams, Aaron M Stoker, James P Stannard, Emma Teixeiro, James L Cook

Prolonged and incomplete osteochondral allograft (OCA) osteointegration is consistently cited as a major mechanism for OCA treatment failure. Subrejection immune responses may play roles in this mode of failure. Preimplantation OCA preparation techniques, including subchondral bone drilling, thorough irrigation, and autogenous bone marrow aspirate concentrate saturation, may dampen immune responses and improve OCA osteointegration. This study sought to further characterize potential immune system contributions to OCA transplantation treatment failures by analyzing donor-recipient ABO and Rh-factor mismatches and histological and immunohistochemical assessments of transplanted OCA tissues recovered from revision surgeries. Using a dedicated registry, OCA transplant recipients with documented treatment failures who met inclusion criteria (n = 33) as well as age-, body mass index-, and joint-matched patients with successful outcomes (n = 70) were analyzed to compare matched cohorts of patients with successful versus failed OCA transplantation outcomes. Tissues recovered from 18 failed OCA transplants and portions of 7 nonimplanted OCA controls were further analyzed to provide contributing evidence for potential immune response mechanisms. For patients analyzed, no statistically significant differences in proportions for treatment success versus failure based on mismatches for ABO type, Rh factor, or both were noted. Further, no statistically significant differences in proportions for histological immune response presence or absence based on mismatches for ABO type, Rh factor, or both were noted. Twelve (67%) of the failed OCA tissues contained lymphocyte aggregations in the subchondral bone, which were comprised of combinations of CD3 + , CD4 + , CD8 + , and CD20+ lymphocytes. The mechanisms of failure for these 12 OCA transplants involved insufficient OCA osteointegration. Results of this study suggest that T- and B-cell-mediated subrejection immune responses may play roles in OCA transplant treatment failures independent of donor-recipient blood type mismatch effects.

骨软骨异体移植物(OCA)骨结合时间延长和不完全一直被认为是 OCA 治疗失败的主要原因。排斥反应下的免疫反应可能是导致治疗失败的原因之一。OCA植入前的准备技术,包括软骨下骨钻孔、彻底冲洗和自体骨髓抽吸浓缩物饱和,可抑制免疫反应并改善OCA的骨结合。本研究试图通过分析供体与受体的ABO和Rh因子不匹配情况,以及从翻修手术中回收的移植OCA组织的组织学和免疫组化评估,进一步确定免疫系统对OCA移植治疗失败的潜在影响。通过一个专门的登记处,分析了符合纳入标准且有治疗失败记录的OCA移植受者(n = 33)以及年龄、体重指数和关节匹配的成功患者(n = 70),以比较OCA移植成功与失败患者的匹配队列。此外,还进一步分析了从 18 例移植失败的 OCA 患者和 7 例未移植 OCA 的对照组患者身上提取的组织,为潜在的免疫反应机制提供证据。在分析的患者中,根据 ABO 血型、Rh 因子或两者的不匹配情况,治疗成功与失败的比例没有明显的统计学差异。此外,根据ABO血型、Rh因子或两者的不匹配情况,组织学免疫反应存在与否的比例差异也无统计学意义。12 例(67%)失败的 OCA 组织软骨下骨中含有淋巴细胞聚集,由 CD3 +、CD4 +、CD8 + 和 CD20 + 淋巴细胞组合而成。这12例OCA移植失败的机制与OCA骨整合不足有关。这项研究的结果表明,T 细胞和 B 细胞介导的排斥反应可能在 OCA 移植治疗失败中发挥作用,而与供体-受体血型错配效应无关。
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引用次数: 0
Patella Fractures after Total Knee Arthroplasty. 全膝关节置换术后髌骨骨折。
IF 1.6 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-08-30 DOI: 10.1055/a-2376-6721
Gabrielle Swartz, Mohamed Albana, Jeremy A Dubin, Daniel Hameed, Sandeep S Bains, Michael A Mont, Ronald E Delanois, Giles R Scuderi

Periprosthetic patella fractures are a rare complication that can lead to severe disability following total knee arthroplasty (TKA). There are several factors that increase the risk of this injury, including patient comorbidities, anatomic considerations, and surgical technique. With these factors limiting healing ability in the area, periprosthetic patellar fractures can pose a major challenge to treat, with potentially lasting morbidity for affected patients. These fractures can occur at any time following TKA and are classified based on their associated implant stability and disruption of the extensor mechanism using the Ortiguera and Berry classification system. Each of the three types of fractures can be managed in their own unique way; however, outcomes remain poor, and the complication rates remain high regardless of fracture type. This article provides an overview of the current literature and the recommended management of periprosthetic patella fractures.

假体周围髌骨骨折是一种罕见的并发症,可导致全膝关节置换术(TKA)后严重残疾。有多种因素会增加这种损伤的风险,包括患者的并发症、解剖学考虑因素和手术技术。由于这些因素限制了该区域的愈合能力,假体周围髌骨骨折会给治疗带来巨大挑战,并可能给患者带来长期的发病率。这些骨折可发生在 TKA 术后的任何时间,根据相关植入物的稳定性和外展机制的破坏情况,采用 Ortiguera 和 Berry 分类系统进行分类。这三种类型的骨折都有各自独特的处理方法,但无论哪种骨折类型,治疗效果都不理想,并发症发生率也居高不下。本文概述了目前的文献以及髌骨周围骨折的推荐处理方法。
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引用次数: 0
What Is the Correlation between Coronal Plane Alignment Measured on Pre- and Postoperative Weight-bearing Radiographs and Intraoperative Navigation When Stress Is Applied to the Knee? 当膝关节受到压力时,术前和术后负重 X 光片上测量的冠状面对齐情况与术中导航之间的相关性如何?
IF 1.6 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-08-01 Epub Date: 2024-02-09 DOI: 10.1055/a-2265-9896
Anthony O'Neill, Michael McAuliffe, Tristan Pillay, Gautam Garg, Sarah Whitehouse, Ross Crawford

This study examines the correlation between the weight-bearing (WB) long leg radiograph (LLR)-derived hip-knee-ankle angle (HKAA) and intraoperative supine computer-assisted surgery (CAS)-derived HKAA measurements at the beginning and end of total knee arthroplasty (TKA). The primary aim of the study was to determine if WB alignment could be mimicked or inferred based on intraoperative alignment findings. We conducted a prospective analysis from a cohort of 129 TKAs undergoing a CAS TKA at a single center by a single surgeon. The HKAA was recorded using the CAS navigation system immediately postregistration of navigation data and after implantation of the prosthesis. The intraoperative HKAA was recorded in both the supine "resting" position of the knee and also while the knee was manipulated in an effort to replicate the patient's WB alignment. These measurements were compared with the HKAA recorded on pre- and postoperative WB LLRs. There was a strong correlation between the preoperative WB LLR HKAA and the intraoperative preimplant CAS-derived stressed HKAA (R = 0.946). However, there was no correlation between the postoperative WB LLR HKAA and the postimplant insertion HKAA as measured intraoperatively via CAS for either a "resting" or "stressed" position of the operated knee (R = 0.165 and R = 0.041, respectively). Thus, the interpretation of intraoperative alignment data is potentially problematic. Despite technological advances in the development and utilization of computer navigation and robotics in arthroplasty to help obtain the optimal alignment, it would seem apparent from our study that this alignment does not correlate to upright stance postoperatively. Surgeons should apply caution to the strength of assumptions they place on intraoperative coronal plane alignment findings.

本研究探讨了在全膝关节置换术(TKA)开始和结束时,负重(WB)长腿X光片(LLR)得出的髋膝踝角度(HKAA)与术中仰卧位计算机辅助手术(CAS)得出的 HKAA 测量值之间的相关性。该研究的主要目的是确定能否根据术中对位结果模仿或推断负重对位。我们对一个中心由一名外科医生进行的 129 例 TKA 进行了前瞻性分析。在导航数据注册后和假体植入后,立即使用 CAS 导航系统记录 HKAA。术中HKAA在膝关节仰卧 "静止 "位和膝关节摆动时均有记录,目的是复制患者的负重排列。这些测量结果与术前、术后 WB LLRs 记录的 HKAA 进行了比较。术前 WB LLR HKAA 与术中植入前 CAS 得出的应力 HKAA 之间存在很强的相关性(R= 0.946)。但是,对于手术膝关节的 "静息 "或 "受力 "位置,术后 WB LLR HKAA 与术中通过 CAS 测量的植入后 HKAA 之间没有相关性(R = 0.165 和 R = 0.041)。因此,术中对位数据的解释可能存在问题。尽管在关节置换术中开发和利用计算机导航和机器人技术以帮助获得最佳对位方面取得了技术进步,但从我们的研究中可以明显看出,这种对位与术后直立站姿并不相关。外科医生应谨慎对待术中冠状面对位结果的假设强度。
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引用次数: 0
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Journal of Knee Surgery
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