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Enrollment in a Behavioral Health Program Positively Impacts 2-Year Cumulative Survival Rates in Osteochondral Allograft Transplant Patients. 参加行为健康项目对骨软骨异体移植患者的 2 年累积存活率有积极影响。
IF 1.6 4区 医学 Q3 ORTHOPEDICS Pub Date : 2025-01-01 Epub Date: 2024-09-05 DOI: 10.1055/s-0044-1790252
Jonathan Williams, Kylee Rucinski, Renee Stucky, James P Stannard, Cory R Crecelius, Aaron M Stoker, Clayton W Nuelle, James L Cook

Emerging evidence suggests that patients' behavioral health may influence outcomes after osteochondral allograft transplantation (OCAT). A comprehensive behavioral health program (BHP) including preoperative screening and education, and postoperative counseling and support, led by a health behavior psychologist was implemented for patients considering OCAT. We hypothesized that patients undergoing knee OCAT and enrolled in the BHP would have a significantly higher 2-year graft survival rate than those not enrolled. Prospectively collected data for patients undergoing knee OCAT enrolled in the lifelong outcomes registry were analyzed. Based on the timing of implementation of a comprehensive BHP to provide preoperative screening and education followed by postoperative counseling and support, BHP and no-BHP cohorts were compared. Treatment failure was defined as the need for either OCAT revision surgery or knee arthroplasty. The Kaplan-Meier method using log-rank tests compared cumulative survival rates. Multivariable Cox regression analysis was used to determine the effects of confounding variables on the influence of BHP enrollment on graft survival. A total of 301 patients were analyzed (no-BHP = 220 and BHP = 81). At 2-year follow-up, a significantly lower cumulative graft survival rate was observed for patients not enrolled in the BHP (68.2 vs. 91.4%; p = 0.00347). Adjusting for sex, age, body mass index, tobacco use, tibiofemoral bipolar OCAT type surgery, and nonadherence, patients not enrolled in the BHP were 2.8 times more likely to experience OCAT treatment failure by 2 years after primary OCAT compared with patients in the BHP (95% confidence interval, 1.02-4.98; p = 0.01). A comprehensive BHP contributes to significant improvements in 2-year graft survival rates following OCAT in the knee. Preoperative mental and behavioral health screening and support for shared decision-making regarding treatment options, in conjunction with patient and caregiver education and assistance through integrated health care team engagement, are beneficial to patients pursuing complex joint preservation surgeries. Level of evidence is 2, prospective cohort study.

新的证据表明,患者的行为健康可能会影响骨软骨异体移植(OCAT)后的疗效。我们为考虑接受 OCAT 的患者实施了一项全面的行为健康计划(BHP),包括术前筛查和教育以及术后咨询和支持,由一名健康行为心理学家负责。我们假设,接受膝关节OCAT手术并加入BHP的患者的2年移植物存活率将明显高于未加入BHP的患者。我们分析了前瞻性收集到的膝关节OCAT患者终身结果登记数据。根据提供术前筛查和教育以及术后咨询和支持的综合必赢国际注册的实施时间,比较了必赢国际注册队列和无必赢国际注册队列。治疗失败的定义是需要进行OCAT翻修手术或膝关节置换术。采用对数秩检验的 Kaplan-Meier 法比较了累积存活率。多变量 Cox 回归分析用于确定混杂变量对 BHP 注册对移植物存活率的影响。共分析了 301 例患者(无 BHP = 220 例,BHP = 81 例)。在 2 年的随访中,未加入 BHP 的患者的累计移植物存活率明显较低(68.2% vs. 91.4%;P = 0.00347)。在对性别、年龄、体重指数、吸烟、胫骨股骨双极OCAT类型手术和不依从性进行调整后,未参加必赢国际注册的患者在初次OCAT治疗后2年内出现OCAT治疗失败的可能性是参加必赢国际注册患者的2.8倍(95%置信区间,1.02-4.98;p = 0.01)。综合必赢国际注册有助于显著提高膝关节 OCAT 术后 2 年的移植物存活率。术前心理和行为健康筛查以及治疗方案共同决策支持,再加上患者和护理人员的教育以及综合医疗团队的协助,对接受复杂关节保留手术的患者大有裨益。证据等级为2级,前瞻性队列研究。
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引用次数: 0
Letter to the Editor on "A Longitudinal Analysis of Weight Changes before and after Total Knee Arthroplasty: Weight Trends, Patterns, and Predictors". 致编辑的信--"全膝关节置换术前后体重变化的纵向分析:体重趋势、模式和预测因素 "的文章。
IF 1.6 4区 医学 Q3 ORTHOPEDICS Pub Date : 2025-01-01 Epub Date: 2024-09-06 DOI: 10.1055/a-2411-0835
Daniel L Riddle
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引用次数: 0
Posterior Cruciate Ligament Preservation versus Posterior Cruciate Ligament Sacrifice: Comparing Patient Outcomes in Medial Congruent Total Knee Arthroplasty. 保留 PCL 与牺牲 PCL:比较内侧同侧全膝关节置换术的患者疗效。
IF 1.6 4区 医学 Q3 ORTHOPEDICS Pub Date : 2025-01-01 Epub Date: 2024-08-05 DOI: 10.1055/a-2379-6488
George N Guild, Mary J McConnell, Farideh Najafi, Brandon H Naylor, Charles A DeCook, Thomas L Bradbury

This study aimed to compare outcomes and complication rates between posterior cruciate ligament (PCL) retention and excision utilizing a medial congruent (MC) polyethylene insert in total knee arthroplasty (TKA) in a specialized ambulatory surgery center (ASC) dedicated to hip and knee arthroplasty. A retrospective review was performed between May 2023 and October 2023 analyzing 398 patients who underwent primary MC TKA by high-volume joint arthroplasty surgeons (n = 9) with either PCL preservation (n = 264) or sacrifice (n = 134) in a single free-standing ASC. Patients were matched chronologically on a 2:1 basis. Demographics, baseline function, 90-day complications, and patient-reported outcomes were recorded for each patient. There were no differences in preoperative baseline function or patient-reported outcome measures, Charlson Comorbidity Index, or American Society of Anesthesiologists class among patient groups. The PCL-preserve and PCL-sacrifice cohorts showed significant variation in 12-week postoperative Knee Injury and Osteoarthritis Outcome, Junior (KOOS, JR.) scores. Specifically, the number of patients who achieved the minimal clinically important difference (MCID) in KOOS, JR. scores was higher in the PCL-sacrifice group (p < 0.05). Yet, no complications within the 90-day period were associated with PCL status and other patient-reported outcomes. This study comparing outcomes between MC TKAs with PCL retention and sacrifice suggests that both techniques are viable options with similar functional outcomes, pain scores, and complication rates, which may have benefits in an ASC setting. The PCL-sacrifice group exhibited a statistically significant increase in patients who achieved the MCID in KOOS, JR. score compared with the PCL-preserving at early follow-up. Future research should employ prospective, randomized designs to further validate these findings and explore long-term implications.

简介:本研究旨在比较一家专门从事髋关节和膝关节置换术的门诊手术中心(ASC)在全膝关节置换术(TKA)中使用内侧同形(MC)聚乙烯插入物保留后交叉韧带(PCL)和切除后交叉韧带(PCL)的结果和并发症发生率:在2023年5月至2023年10月期间进行了一项回顾性研究,分析了398名患者,这些患者在一家独立的ASC接受了初级MC TKA手术,由高产量的关节置换外科医生(人数=9)实施,并保留了PCL(人数=264)或牺牲了PCL(人数=134)。患者按时间顺序2:1配对。记录每位患者的人口统计学特征、基线功能、90天并发症和患者报告结果:结果:各组患者的术前基线功能、患者报告的结果指标(PROMs)、夏尔森综合指数(COI)或美国麻醉医师协会(ASA)等级均无差异。PCL 保留组和 PCL 牺牲组的术后 12 周膝关节损伤和骨关节炎结果(KOOS,JR.具体而言,PCL-舍弃组中达到 KOOS, JR. 评分最小临床意义差异(MCID)的患者人数较多(p结论:PCL-舍弃组中达到 KOOS, JR. 评分最小临床意义差异(MCID)的患者人数较多(p结论):该手稿比较了保留 PCL 和牺牲 PCL 的 MC TKAs 的疗效,结果表明这两种技术都是可行的选择,具有相似的功能疗效、疼痛评分和并发症发生率,在 ASC 环境中可能有好处。在早期随访中,与保留 PCL 组相比,牺牲 PCL 组在 KOOS、JR.未来的研究应采用前瞻性的随机设计来进一步验证这些发现并探索其长期影响。
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引用次数: 0
The Influence of Preimplant Balancing on Manipulation under Anesthesia Rates following Imageless Robotic-Assisted Total Knee Arthroplasty. 无假象机器人辅助全膝关节置换术后植入前平衡对麻醉下操作率的影响
IF 1.6 4区 医学 Q3 ORTHOPEDICS Pub Date : 2025-01-01 Epub Date: 2024-09-05 DOI: 10.1055/a-2410-2668
Justin T Butler, Samuel D Stegelmann, Trent Davis, Amy Singleton, Hunter Ostlie, Richard Miller, Kirk Davis

Acquired idiopathic stiffness (AIS) following total knee arthroplasty (TKA) often requires manipulation under anesthesia (MUA). Robotic-assisted TKA (RA-TKA) systems provide gap balance templates for objective correlation with the rate of AIS. The purpose of this study was to assess intraoperative balancing parameters that were associated with MUA utilizing an "anatomical" implant design.We performed a retrospective chart review of 265 imageless RA-TKA procedures performed by R.M. and K.D. between 2018 and 2020. The primary outcome for AIS or clinically significant "arthrofibrosis" was MUA. Patient intraoperative gap planning data were examined for association.The rate of MUA was 8.7% (23/265), which was performed at a mean follow-up time of 75.9 ± 32.2 days. The lateral to medial gap difference in extension was significantly less in patients requiring MUA (odds ratio [OR] = 0.86, 95% confidence interval [CI], 0.75-0.99) (p = 0.034). Significantly less preoperative varus mechanical axis was associated with knees requiring MUA (1.83° vs. 4.04°, OR = 1.09, 95% CI, 1.00-1.19). Decreased templated mechanical axis correction was associated with MUA (2.09° vs. 4.75°, p < 0.0001).A tighter lateral-to-medial gap in extension, less preoperative varus, and smaller templated mechanical axis corrections were associated with increased rates of MUA.

背景:全膝关节置换术(TKA)后获得性特发性僵硬(AIS)通常需要在麻醉下进行操作(MUA)。机器人辅助 TKA(R-TKA)系统提供间隙平衡模板,可客观反映 AIS 的发生率。本研究旨在利用 "解剖型 "植入物设计评估与 MUA 相关的术中平衡参数:我们对两位资深外科医生在 2018 年至 2020 年期间实施的 265 例无图像 R-TKA 手术进行了回顾性病历审查。AIS或临床显著的 "关节纤维化 "的主要结果是MUA。对患者术中间隙规划数据进行了关联性检查:MUA率为8.7%(23/265),平均随访时间为75.9±32.2天。需要进行 MUA 的患者外侧与内侧的伸展间隙差异明显较小(OR = 0.86,95% CI,0.75 - 0.99)(p = 0.034)。需要进行 MUA 的膝关节的术前屈曲机械轴明显较小(1.83° vs 4.04°,OR 1.09 95% CI 1.00-1.19)。模板化机械轴校正的减少与 MUA 有关(2.09° vs 4.75° p 结论:伸展时外侧与内侧间隙较紧、术前屈曲较小、模板机械轴校正较小与麻醉下操作率增加有关。
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引用次数: 0
Initial Outcomes following Fresh Meniscus Allograft Transplantation in the Knee. 膝关节新鲜半月板同种异体移植后的初步疗效
IF 1.6 4区 医学 Q3 ORTHOPEDICS Pub Date : 2025-01-01 Epub Date: 2024-08-16 DOI: 10.1055/a-2389-9001
James L Cook, James P Stannard, Kylee J Rucinski, Clayton W Nuelle, Cory R Crecelius, Cristi R Cook, Richard Ma

Based on recent evidence-based advances in meniscus allograft transplantation (MAT), fresh (viable) meniscus allografts have potential for mitigating key risk factors associated with MAT failure, and preclinical and clinical data have verified the safety of fresh meniscus allografts as well as possible efficacy advantages compared with fresh-frozen meniscus allografts. The objective of this study was to prospectively assess clinical outcomes for the initial cohort of patients undergoing MAT using fresh meniscus allografts at our center. Patients who were prospectively enrolled in a dedicated registry were included for analyses when they had undergone primary MAT using a fresh meniscus allograft for treatment of medial and/or lateral meniscus deficiency with at least 1-year follow-up data recorded. Forty-five patients with a mean final follow-up of 47.8 months (range = 12-90 months) were analyzed. The mean patient age was 30.7 years (range = 15-60 years), mean body mass index (BMI) was 29.7 kg/m2 (range = 19-48 kg/m2), and 14 patients (31%) were females. In total, 28 medial, 13 lateral, and 4 combined medial and lateral MATs with 23 concurrent ligament reconstructions and 2 concurrent osteotomies were included. No local or systemic adverse events or complications related to MAT were reported for any patient in the study. Treatment success rate for all patients combined was 91.1% with three patients requiring MAT revision and one patient requiring arthroplasty. Treatment failures occurred 8 to 34 months after MAT and all involved the medial meniscus. None of the variables assessed were significantly different between treatment success and treatment failure cohorts. Taken together, the data suggest that the use of fresh (viable) meniscus allografts can be considered a safe and effective option for medial and lateral MAT. When transplanted using double bone plug suspensory fixation with meniscotibial ligament reconstruction, fresh MATs were associated with a 91% success rate, absence of local or systemic adverse events or complications, and statistically significant and clinically meaningful improvements in patient-reported measures of pain and function at a mean of 4 years postoperatively.

根据最近半月板同种异体移植(MAT)的循证进展,新鲜(存活)半月板同种异体移植物有可能减轻与 MAT 失败相关的关键风险因素,临床前和临床数据已验证了新鲜半月板同种异体移植物的安全性,以及与新鲜冷冻半月板同种异体移植物相比可能存在的疗效优势。本研究的目的是前瞻性地评估本中心使用新鲜半月板异体移植物进行 MAT 治疗的首批患者的临床疗效。前瞻性登记在册的患者只要接受过使用新鲜半月板同种异体材料治疗内侧和/或外侧半月板缺损的初次MAT手术,且至少有1年的随访数据记录,就会被纳入分析范围。45名患者的平均最终随访时间为47.8个月(12-90个月)。患者平均年龄为 30.7 岁(范围 = 15-60),平均体重指数为 29.7 kg/m2(范围 = 19-48),14 名患者(31%)为女性。共纳入了 28 例内侧、13 例外侧、4 例内侧和外侧联合 MAT,23 例同时进行了韧带重建,2 例同时进行了截骨术。研究中没有任何患者出现与 MAT 相关的局部或全身不良反应或并发症。所有患者的治疗成功率合计为91.1%,其中3名患者需要进行MAT翻修,1名患者需要进行关节成形术。治疗失败发生在 MAT 术后 8 至 34 个月,所有失败均涉及内侧半月板。治疗成功与治疗失败组别之间的评估变量均无明显差异。综上所述,这些数据表明,使用新鲜(存活的)半月板同种异体移植物进行内侧和外侧半月板同种异体移植物移植是一种安全有效的选择。在使用双骨栓悬吊固定和半月板胫腓韧带重建术进行移植时,新鲜半月板异体移植物的成功率为 91%,无局部或全身不良事件或并发症,术后平均 4 年,患者报告的疼痛和功能指标均有显著的统计学意义和临床意义的改善。
{"title":"Initial Outcomes following Fresh Meniscus Allograft Transplantation in the Knee.","authors":"James L Cook, James P Stannard, Kylee J Rucinski, Clayton W Nuelle, Cory R Crecelius, Cristi R Cook, Richard Ma","doi":"10.1055/a-2389-9001","DOIUrl":"10.1055/a-2389-9001","url":null,"abstract":"<p><p>Based on recent evidence-based advances in meniscus allograft transplantation (MAT), fresh (viable) meniscus allografts have potential for mitigating key risk factors associated with MAT failure, and preclinical and clinical data have verified the safety of fresh meniscus allografts as well as possible efficacy advantages compared with fresh-frozen meniscus allografts. The objective of this study was to prospectively assess clinical outcomes for the initial cohort of patients undergoing MAT using fresh meniscus allografts at our center. Patients who were prospectively enrolled in a dedicated registry were included for analyses when they had undergone primary MAT using a fresh meniscus allograft for treatment of medial and/or lateral meniscus deficiency with at least 1-year follow-up data recorded. Forty-five patients with a mean final follow-up of 47.8 months (range = 12-90 months) were analyzed. The mean patient age was 30.7 years (range = 15-60 years), mean body mass index (BMI) was 29.7 kg/m<sup>2</sup> (range = 19-48 kg/m<sup>2</sup>), and 14 patients (31%) were females. In total, 28 medial, 13 lateral, and 4 combined medial and lateral MATs with 23 concurrent ligament reconstructions and 2 concurrent osteotomies were included. No local or systemic adverse events or complications related to MAT were reported for any patient in the study. Treatment success rate for all patients combined was 91.1% with three patients requiring MAT revision and one patient requiring arthroplasty. Treatment failures occurred 8 to 34 months after MAT and all involved the medial meniscus. None of the variables assessed were significantly different between treatment success and treatment failure cohorts. Taken together, the data suggest that the use of fresh (viable) meniscus allografts can be considered a safe and effective option for medial and lateral MAT. When transplanted using double bone plug suspensory fixation with meniscotibial ligament reconstruction, fresh MATs were associated with a 91% success rate, absence of local or systemic adverse events or complications, and statistically significant and clinically meaningful improvements in patient-reported measures of pain and function at a mean of 4 years postoperatively.</p>","PeriodicalId":48798,"journal":{"name":"Journal of Knee Surgery","volume":" ","pages":"35-42"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of Multiligament Knee Injuries Using Anatomic Autograft Reconstructions: A Case Series. 利用解剖自体移植重建治疗膝关节多韧带损伤:病例系列。
IF 1.6 4区 医学 Q3 ORTHOPEDICS Pub Date : 2025-01-01 Epub Date: 2024-10-11 DOI: 10.1055/s-0044-1791648
Maxime Guerot, Baptiste Boukebous, Lucas Chanteux, Haroun Bouhali, Marc-Antoine Rousseau, Cédric Maillot

While proven effective management of multiligament knee injury (MLKI) using allograft is often reported, it has shown an increased risk for graft failure compared with autograft and raises availability and cost issues. Osseous stock preservation and tunnel convergence avoidance led us to develop a compromise innovative surgical procedure using only ipsilateral autograft for anatomic reconstruction of Schenck III-L or higher MLKI. We report the description and early outcomes of our initial experience. Our strategy consisted of an anatomic single-bundle posterior cruciate ligament reconstruction with quadriceps tendon autograft and a "Versailles" reconstruction for the posterolateral corner, which we modified to reconstruct the anterolateral ligament in case of anteromedial rotatory instability, called "full lateral." A second-stage surgery was planned for anterior cruciate ligament reconstruction using a bone-patellar tendon-bone autograft. Outcomes were Lysholm, Tegner, and International Knee Documentation Committee (IKDC) scores for functional status, Short Form 12 (SF-12) for quality of life, and visual analog scale (VAS) for pain. Complications, full weight-bearing, return to work, and sport were also computed. Between March 2019 and August 2020, 10 patients were included. At follow-up, light pain was found in nine patients with a mean VAS of 1.2 ± 2.16 during the day. The mean Lysholm, Tegner, and subjective IKDC scores were good, with 61.2 ± 20.6, 2.8 ± 2.1, and 52.6 ± 20.4, respectively. However, quality of life was altered with poor SF-12 scores. In our first 10 patients with Schenck III-L or higher MLKI, our procedure using only ipsilateral autograft enabled correct daily knee functional activities while preserving osseous stock.

虽然使用异体移植物有效治疗膝关节多韧带损伤(MLKI)的报道屡见不鲜,但与自体移植物相比,异体移植物会增加移植物失败的风险,并引发可用性和成本问题。骨质保留和避免隧道汇聚促使我们开发出一种折中的创新手术方法,仅使用同侧自体移植物对申克 III-L 或更高的 MLKI 进行解剖重建。我们报告了初步经验的描述和早期结果。我们的策略包括使用股四头肌肌腱自体移植进行解剖单束后交叉韧带重建,并对后外侧角进行 "凡尔赛 "重建,在出现前内侧旋转不稳的情况下,我们将其修改为重建前外侧韧带,称为 "全外侧"。第二阶段手术计划使用骨-髌腱-骨自体移植物重建前十字韧带。研究结果包括莱斯霍尔姆(Lysholm)、泰格纳(Tegner)和国际膝关节文献委员会(IKDC)的功能状态评分、SF-12生活质量短表(SF-12)和疼痛视觉模拟量表(VAS)。此外,还计算了并发症、完全负重、恢复工作和运动的情况。在2019年3月至2020年8月期间,共纳入了10名患者。随访时发现,9 名患者白天有轻微疼痛,VAS 平均值为 1.2 ± 2.16。Lysholm、Tegner和主观IKDC评分均为良好,分别为(61.2 ± 20.6)、(2.8 ± 2.1)和(52.6 ± 20.4)。但是,生活质量有所改变,SF-12 评分较低。在我们的首批 10 例 Schenck III-L 或更高 MLKI 患者中,我们的手术仅使用同侧自体移植物,在保留骨量的同时实现了正确的日常膝关节功能活动。
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引用次数: 0
Comparing the Rate of Dissolution of Two Commercially Available Synthetic Bone Graft Substitutes. 比较两种市售合成骨移植替代物的溶解速度
IF 1.6 4区 医学 Q3 ORTHOPEDICS Pub Date : 2025-01-01 Epub Date: 2024-09-05 DOI: 10.1055/a-2410-2552
Kara McConaghy, Michael Smietana, Ignacio Pasqualini, Pedro J Rullán, Jesse Fleming, Nicolas S Piuzzi

This study characterized the dissolution properties of two commercially available bone substitutes: (1) A calcium sulfate (CaS)/brushite/β-tricalcium phosphate (TCP) graft containing 75% CaS and 25% calcium phosphate; and (2) a CaS/hydroxyapatite (HA) bone graft substitute composed of 60% CaS and 40% HA. Graft material was cast into pellets (4.8 mm outer diameter × 3.2 mm). Each pellet was placed into a fritted thimble and weighed before being placed into 200 mL of deionized water. The pellets were removed from the water on days 1, 2, 3, 4, 6, 8, 14, 18, or until no longer visible. The mass and volume of each pellet were calculated at each timepoint to determine the rate of dissolution. Analysis of variance was performed on all data. Statistical significance was defined as p < 0.05. The CaS/HA pellets were completely dissolved after day 8, while the CaS/brushite/β-TCP pellets remained until day 18. The CaS/brushite/β-TCP pellets had significantly more mass and volume at days 1, 2, 3, 4, 6, and 8 timepoints. The CaS/brushite/β-TCP pellets lost 46% less mass and 53% less volume over the first 4 days as compared to CaS/HA pellets. The CaS/brushite/β-TCP pellets had a rough, porous texture, while the CaS/HA pellets had a smooth outer surface. Overall the CaS/brushite/β-TCP pellets dissolved approximately twice as slowly as the CaS/HA pellets in vitro. As these in vitro findings might have in vivo implications, further clinical data are required to further confirm and establish the optimal synthetic bone substitute strategy or antibiotic delivery carrier.

本研究分析了两种市售骨替代物的溶解特性:1)半水合硫酸钙(CSH)/毛刷石/β-磷酸三钙(TCP)移植材料,含 75% 的硫酸钙(CaS)和 25% 的磷酸钙;以及 2)CaS/羟基磷灰石(HA)骨移植替代物,含 40% 的 HA 和 60% 的 CaS。移植材料被浇铸成颗粒(外径 4.8 毫米 x 3.2 毫米)。将每个颗粒放入一个有折痕的顶针中,称重后再放入 200 毫升去离子水中。在第 1、2、3、4、6、8、14、18 天或直到不再可见时,将颗粒从水中取出。在每个时间点计算每个颗粒的质量和体积,以确定溶解速率。对所有数据进行方差分析(ANOVA)。统计显著性定义为 p < 0.05。CaS/HA 颗粒在第 8 天后完全溶解,而 CSH/brushite/β- TCP 颗粒则保持到第 18 天。在第 1、2、3、4、6 和 8 天的时间点上,CSH/亚刷石/β- TCP 颗粒的质量和体积明显更大。与 CaS/HA 颗粒相比,CSH/亚刷石/β-TCP 颗粒在前 4 天的质量和体积损失分别减少了 46%和 53%。CSH/刷石/β-TCP颗粒的质地粗糙多孔,而CaS/HA颗粒的外表面光滑。总的来说,CSH/毛刷石/β-TCP 颗粒在体外的溶解速度大约是 CaS/HA 颗粒的两倍。由于这些体外研究结果可能会对体内产生影响,因此需要进一步的临床数据来进一步确认和确定最佳的合成骨替代物策略或抗生素输送载体。
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引用次数: 0
The Impact of Anterior Cruciate Ligament Tear on Player Performance and Longevity in La Liga League Soccer Players. 前十字韧带撕裂对西甲联赛球员表现和寿命的影响。
IF 1.6 4区 医学 Q3 ORTHOPEDICS Pub Date : 2025-01-01 Epub Date: 2024-10-29 DOI: 10.1055/s-0044-1791985
Abdullah N Ghali, Philip Ghobrial, David A Momtaz, Hari N Krishnakumar, Rishi K Gonuguntla, Yousef Salem, Amir AlSaidi, Katherine C Bartush, David M Heath

Anterior cruciate ligament (ACL) rupture is among the most studied sports injuries. We investigate the impact of ACL reconstruction (ACLR) on performance and longevity in La Liga to elucidate performance parameters impacted after surgery in professional soccer players and variables impacting return-to-play (RTP).Demographic and performance data for La Liga players with ACLR between 1993 and 2020 were collected three seasons before and after injury and compared with two healthy controls. Analysis was conducted between and within ACLR and control groups. Pearson's correlation coefficients and a multiple linear regression model analyzed relationships between demographic variables and RTP.After exclusion, 23 professional soccer players were identified for the ACLR group. One year after index, ACLR had lower goals, shots on-target, assists, pass percentage, tackles, tackle success percentage, blocks, and clearances compared with control (p < 0.05). Two years after index, ACLR had lower assists, pass percentage, and tackle success percentage than control (p < 0.05). Three years after index, ACLR had fewer matches and blocks versus control (p < 0.05). Pearson's correlation showed a positive correlation between experience and RTP (p = 0.001). Multiple linear regression found RTP to increase 32.66 days for each additional year of experience (p < 0.001).With performance metrics showing significant decreases up to 2 years post-ACLR but largely recovering within 3 years of RTP, results support that soccer players undergoing ACLR eventually recover to preinjury levels of play. Players should be counseled on initial declines in performance metrics the first few years after RTP.

前十字韧带(ACL)断裂是研究最多的运动损伤之一。我们调查了前十字韧带重建(ACLR)对西甲联赛球员表现和寿命的影响,以阐明职业足球运动员手术后影响表现的参数以及影响重返赛场(RTP)的变量。我们收集了 1993 年至 2020 年期间接受前十字韧带重建的西甲球员在受伤前后三个赛季的人口统计学和表现数据,并与两名健康对照组进行了比较。在前交叉韧带损伤组和对照组之间及内部进行了分析。皮尔逊相关系数和多元线性回归模型分析了人口统计学变量和 RTP 之间的关系。与对照组相比,ACLR 组的进球数、射门命中率、助攻数、传球率、拦截率、拦截成功率和解围率均低于对照组(p p p = 0.001)。多元线性回归发现,每增加一年经验,RTP 就会增加 32.66 天(p
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引用次数: 0
Radiographic Assessment of Total Knee Arthroplasty Alignment With and Without Accelerometer-Based Navigation at a Resident Training Institution. 一家住院医师培训机构在使用和未使用加速度计导航的情况下对全膝关节置换术的对位情况进行放射学评估。
IF 1.6 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-12-27 DOI: 10.1055/a-2481-8647
Brett G Brazier, Christian B Allen, Daryl G Hilyard, Darshan S Shah, David E Vizurraga, Donald N Hope

Malalignment and lack of surgeon experience are cited as risk factors for prosthetic failure and the need for subsequent revision surgery in total knee arthroplasty (TKA). Various conventional (CON) and computer-assisted surgical (CAS) methods have been developed to try and prevent malalignment and limit outliers. One of these methods is through an accelerometer-based CAS (aCAS), which intraoperatively helps determine the angulation and amount of resection necessary to restore alignment in TKA. The purpose of this study was to determine the number of TKA alignment outliers in TKAs performed both with CON and aCAS methods at a single training institution in cases that trainees were involved in. In this retrospective single-center study, radiographic analysis of 150 primary TKAs performed at our training institution was performed. The medial distal femoral angle (DFA), medial proximal tibial angle (PTA), and posterior slope angle (PSA) were evaluated on immediate postoperative radiographs of 75 aCAS and 75 CON knees. Outlier measurements were defined as DFA outside of 5 ± 3 degrees valgus, PTA > ± 3 degrees from neutral axis, and PSA outside 0 to 7 degrees for cruciate retaining and 0 to 5 degrees for posterior stabilized implants. Data was analyzed using chi-squared, analysis of variance, and Student's t-tests. There was no significant difference found between these two groups in the total number of outliers (8% aCAS vs. 9.8% CON, p = 0.508). Additionally, there was also no significant difference found for any of the radiographic measurements independently; DFA (8% vs. 8%, p = 1.00), PTA (4% vs. 9%, p = 0.184), and PSA (12% vs. 12%, p = 1.00), when comparing aCAS and CON TKAs. Primary TKAs performed at a single training institution demonstrated no significant difference between aCAS and CON methods in the total number of outliers or in the number of outliers for each postoperative radiographic measurement. This study would suggest that there is no advantage in limiting outliers when utilizing aCAS for TKAs at training institutions in cases that trainees are involved in. LEVEL OF EVIDENCE:  Level III Retrospective Cohort Study.

导言:在全膝关节置换术(TKA)中,错位和外科医生经验不足被认为是导致假体失败和需要进行后续翻修手术的风险因素。目前已开发出各种常规(CON)和计算机辅助手术(CAS)方法,试图防止对位不当和限制异常值。其中一种方法是通过基于加速度计的 CAS(aCAS),在术中帮助确定恢复 TKA 对准所需的角度和切除量。本研究的目的是确定在一个培训机构的受训者参与的病例中,采用CON和aCAS方法进行的TKA对位异常值的数量:在这项回顾性单中心研究中,我们对培训机构实施的 150 例初次 TKA 进行了放射学分析。在 75 个 aCAS 和 75 个 CON 膝关节的术后即刻 X 光片上评估了股骨远端内侧角 (DFA)、胫骨近端内侧角 (PTA) 和后斜角 (PSA)。离群测量的定义是:DFA超出外翻5°±3°;PTA超出中轴±3°;PSA超出0-7°(CR)和0-5°(PS)(Posterior Stabilized)。数据采用卡方检验、方差分析和学生 t 检验进行分析:结果:两组的异常值总数没有明显差异(8% aCAS 对 9.8% CON,P=0.508)。此外,在对 aCAS 和 CON TKA 进行比较时,DFA(8% 对 8%,P=1.00)、PTA(4% 对 9%,P=0.184)和 PSA(12% 对 12%,P=1.00)等放射学测量结果也无明显差异:在一家培训机构进行的初级 TKA 显示,aCAS 和 CON 方法在异常值总数或术后各影像学测量的异常值数量方面没有显著差异。这项研究表明,在培训机构的受训者参与的病例中,使用 aCAS 进行 TKAs 时,限制异常值没有优势。
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引用次数: 0
Size-Up, Size-Down: Accuracy of Component Sizing with Computerized Tomography and Robotic-Assisted Total Knee Arthroplasty. 尺寸增大,尺寸减小:计算机断层扫描和机器人辅助全膝关节置换术的组件尺寸准确性。
IF 1.6 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-12-17 DOI: 10.1055/s-0044-1800976
James P Henry, Brienne Paradis, Aleksandra Qilleri, Nadia Baichoo, Keith R Reinhardt, James D Slover, Jonathan R Danoff, James A Germano

Templating prior to total knee arthroplasty (TKA) can help to improve surgical efficiency and potentially improve alignment and outcomes. The purpose of this article is to evaluate the ability of computed tomography (CT)-based preoperative templating to accurately predict implant sizes. A total of 724 Stryker MAKO robotic-assisted TKA cases were retrospectively evaluated from a prospectively collected database between January 2020 and October 2023. Cases were performed by one of three adult reconstruction fellowship-trained orthopaedic surgeons from a health system that includes an academic level one trauma center, an ambulatory surgery center, and a community hospital. Out of the 724 cases, 391 were preoperatively templated independently by the surgeon and the company representative (MAKO Product Specialist [MPS]). The remaining 333 cases were only templated prior to incision by the MPS. Final implant sizes of the tibial and femoral components were compared to preoperative templates. The MPS was able to preoperatively predict the final tibial and femoral implants within one size in 97.2 and 97.8% of cases, respectively. A surgeon and MPS combined preoperative templating increased accuracy to predict the final tibial and femoral implants within one size in 98.9 and 99.5% of cases, respectively. Height and weight were positively correlated with the final implant size (p < 0.001). Non-surgeons can reliably predict implanted components in CT-based preoperative templating in the majority of cases, which is further enhanced by surgeon review and adjustments. In no cases in our series were the final size components implanted greater than two sizes larger or smaller. Our findings suggest that there is opportunity to avoid waste by processing fewer trial implants and transporting fewer components. This would likely decrease overall case cost and improve efficiency in the operating room. Level of evidence: III (retrospective cohort).

全膝关节置换术(TKA)前的模板可以帮助提高手术效率,潜在地改善对齐和结果。本文的目的是评估基于计算机断层扫描(CT)的术前模板准确预测种植体大小的能力。从前瞻性收集的数据库中回顾性评估2020年1月至2023年10月期间共有724例Stryker MAKO机器人辅助TKA病例。病例由来自卫生系统的三名接受过重建研究金培训的成人骨科医生中的一名进行手术,该卫生系统包括一个学术一级创伤中心、一个流动外科中心和一个社区医院。在724例中,391例术前由外科医生和公司代表(MAKO产品专家[MPS])独立模板。其余333例仅在切口前经MPS模板化。将胫骨和股骨假体的最终植入物大小与术前模板进行比较。在97.2和97.8%的病例中,MPS能够在术前预测最终的胫骨和股骨植入物在一个尺寸内。外科医生和MPS联合术前模板分别在98.9%和99.5%的病例中提高了预测胫骨和股骨植入物最终尺寸的准确性。身高和体重与最终种植体大小呈正相关(p
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引用次数: 0
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Journal of Knee Surgery
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