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European Annals of Otorhinolaryngology-Head and Neck Diseases最新文献

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Improving the language environment for children with cochlear implants, using the LENA language and environment analysis system – A CONSORT analysis 利用LENA语言与环境分析系统- A CONSORT分析,改善人工耳蜗植入儿童的语言环境。
IF 2.4 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.anorl.2025.04.004
M. Lathuilliere , I. Prang , M.-C. Picot , V. Macioce , M. Mondain , N. Loundon

Objectives

To assess the contribution of family counseling based on Language and Environment Analysis (LENA) recording data to improving the language environment of children with cochlear implants.

Material and methods

Cochlear implanted children with prelingual deafness were included from 2 French cochlear implant centers and randomized between 2 age-matched groups: intervention and control. LENA recording and lexical assessment (PPVT–R or GAEL-P) were performed at T1 and, 5 months later, T2. Between the two, intervention group families received feedback from the LENA recording and parental counseling.

Endpoints

The main endpoint was improvement in language environment after LENA-based family counseling: adult word count (AWC), child vocalizations (CV), conversational turns (CT), and TV/media exposure (TV). Secondary endpoints comprised feasibility of LENA and the impact of the language environment on language reception (PPVT–R and GAEL-P scores).

Results

Eighty-three of the 90 included children were analyzed. Mean age was 39 ± 14.2 months, with 43 boys. Between T1 and T2, CT increased by 15 percentiles in the intervention group, in contrast to a median 0 change in controls (P = 0.03). For the other 3 LENA parameters (CV, AWC, TV), median change was zero, in both groups. Mean implant acceptability rating was 83%. Lexical reception scores correlated positively with CV (r = 0.37, P < 0.01), AWC (r = 0.31, P < 0.01) and CT (r = 0.41, P < 0.01) but not with TV (r = 0.11, P = 0.33).

Conclusion

The LENA system can help parents optimize the child's language environment, and thus oral language development, particularly in young children.
目的:评价基于语言与环境分析(LENA)记录数据的家庭咨询对改善人工耳蜗儿童语言环境的贡献。材料与方法:从2个法国人工耳蜗中心选取植入人工耳蜗的语前耳聋患儿,随机分为干预组和对照组。在T1和5个月后T2分别进行LENA记录和词汇评估(PPVT-R或GAEL-P)。在这两者之间,干预组家庭从LENA记录和家长咨询中获得反馈。终点:主要终点是基于lena的家庭咨询后语言环境的改善:成人字数(AWC),儿童发声(CV),会话次数(CT)和电视/媒体曝光(TV)。次要终点包括LENA的可行性和语言环境对语言接受的影响(PPVT-R和GAEL-P评分)。结果:对90例患儿中的83例进行了分析。平均年龄39±14.2个月,男43例。在T1和T2之间,干预组的CT增加了15个百分位数,而对照组的中位数变化为0 (P=0.03)。对于其他3个LENA参数(CV、AWC、TV),两组的中位数变化均为零。平均种植体可接受率为83%。词汇接受得分与CV呈正相关(r=0.37, p)。结论:LENA系统可以帮助家长优化孩子的语言环境,从而促进口语发展,尤其是幼儿。
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引用次数: 0
Postoperative-alveolar bone graft assessment for cleft palate repair using CT 使用 CT 评估腭裂修复术后牙槽骨移植情况。
IF 2.4 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.anorl.2024.12.001
S. Salma , S.A. Khan , D.T. Ginat
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引用次数: 0
Experimental procedure on a royal skull base 皇家颅底的实验程序。
IF 2.4 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.anorl.2025.09.001
R. Baudouin , F. Simon
In 1403, in the battle of Shrewsbury, young Prince Henry, the future Henry V of England (1387–1422), was seriously wounded by an arrow that struck him under his left eye and reached the base of his skull. That he survived was thanks to John Bradmore (date of birth unknown; died 1412), a surgeon and also a metalworker, who designed an original instrument enabling progressive extraction of the arrowhead. He then applied irrigation with wine, honey dressings and a resinous ointment, which achieved healing in 20 days. This story is an illustration of the creativity and experimental attitude at the heart of medical intervention: faced with a desperate situation, Bradmore proved able to invent and apply an adapted solution. The Prince's recovery had major historic consequences: Henry V went on the lead the victorious battle of Agincourt, impose the treaty of Troyes on France and turn relations between the two countries upside down. Little known in France but renowned in Britain, this achievement stands as a reminder that surgical ingenuity can change the destiny not only of a patient but also of nations.
1403年,在什鲁斯伯里战役中,年轻的亨利王子,即未来的英格兰亨利五世(1387-1422),被一支箭射中左眼下方,伤得很重,射中了头骨底部。他能活下来要感谢约翰·布拉德莫尔(出生日期不详,死于1412年),他是一名外科医生,也是一名金属工人,他设计了一种能够逐步取出箭头的原始仪器。然后他用葡萄酒、蜂蜜敷料和树脂软膏进行冲洗,20天后就愈合了。这个故事是医疗干预核心的创造力和实验态度的一个例证:面对绝望的情况,布拉德莫尔证明了自己能够发明并应用一种适应的解决方案。王子的康复产生了重大的历史影响:亨利五世领导了阿金库尔战役的胜利,将特鲁瓦条约强加于法国,并使两国关系发生了翻天覆地的变化。这一成就在法国鲜为人知,但在英国却享有盛誉,它提醒人们,外科手术的独创性不仅可以改变病人的命运,也可以改变一个国家的命运。
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引用次数: 0
Binaural performance in 155 adults with single-sided or asymmetric profound hearing loss: A STROBE analysis 155例成人单侧或不对称重度听力损失的双耳表现:一项STROBE分析。
IF 2.4 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.anorl.2025.06.004
M. Marx , S. Taoui , I. Mosnier , F. Venail , M. Mondain , A. Uziel , D. Bakhos , E. Lescanne , Y. NGuyen , D. Bernardeschi , O. Sterkers , B. Godey , G. Creff , S. Schmerber , N.-X. Bonne , C. Vincent , B. Fraysse , O. Deguine , B. Lepage

Objectives

To estimate the proportion of subjects with single-sided or asymmetric profound hearing loss who achieve normal binaural performance, and to identify their specific demographic and audiological characteristics.

Material and methods

A French nationwide multicenter cross-sectional study included 155 subjects with single-sided or asymmetric profound hearing loss between 2014 and 2018. Speech-in-noise reception was assessed on the FraMatrix test in diotic, dichotic and reverse dichotic conditions to determine the signal-to-noise ratio allowing 50% correct reception. Sound localization was evaluated using a 180° 7-speaker horizontal array around the subject, to measure the root mean square error. The article was written following STROBE guidelines.

Results

Nineteen of the 155 subjects with single-sided (n = 104) or asymmetric profound hearing loss (n = 51) achieved normal scores for diotic speech reception in noise (i.e., critical signal-to-noise ratio better than −4.8 dB), and 9 subjects (7.1%) had normal sound localization (i.e., < 30° error). In the 44 subjects (28.4%) with normal or near-normal diotic signal-to-noise ratio (better than −3 dB), had significantly better hearing thresholds in the better ear, and notably for high frequencies between 2 and 4 kHz.

Conclusion

In this cross-sectional study, 7.1% to almost 30% of subjects with single-sided or asymmetric profound hearing loss showed normal or near-normal binaural performance. Their main distinguishing audiological feature was better hearing thresholds in the better ear, which suggests compensatory strategies based on monaural spectral cues.
目的:估计单侧或不对称深度听力损失受试者双耳正常表现的比例,并确定其特定的人口统计学和听力学特征。材料和方法:一项法国全国性多中心横断面研究,包括2014年至2018年期间155名单侧或不对称深度听力损失患者。在二分、二分和反向二分条件下,通过FraMatrix测试评估语音在噪声中的接收情况,以确定允许50%正确接收的信噪比。通过在受试者周围放置一个180°的7个扬声器水平阵列来评估声音定位,以测量均方根误差。本文是按照STROBE指南编写的。结果155例单侧或非对称型重度听力损失患者中有19例(n=104)在噪声环境下语音接收得分正常(即临界信噪比优于-4.8dB), 9例(7.1%)声音定位正常(即)。结论:在本横断面研究中,7.1%至近30%的单侧或非对称型重度听力损失患者双耳表现正常或接近正常。他们的主要区别听力学特征是较好的耳朵有较好的听力阈值,这表明了基于单耳频谱线索的补偿策略。
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引用次数: 0
Skull Vibration Induced afternystagmus: A new clinical indicator of superior canal dehiscence 颅骨震动诱发眼球震颤:一种新的上管开裂临床指标。
IF 2.4 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.anorl.2025.06.009
G. Dumas , I.S. Curthoys , A. Baguant , P. Perrin , S. Schmerber
Vibrations applied to the cranium induce, in 55%–92% of patients with CT-verified superior canal dehiscence (SCD), a perstimulatory nystagmus most often ipsilaterally beating when the vertex location is stimulated at 100 Hz. The skull vibration-induced nystagmus (SVIN) test is a bone-conducted (BC) Tullio phenomenon in patients with a 3rd mobile window syndrome (TMWS). Here, we describe the technical cues and procedures to obtain an afternystagmus regularly observed in 55% of a series of 43 patients with SCD chosen as examples and stimulated at 100 Hz and higher frequencies by bone-conducted vibrations (BCV). Only 6% of 32 patients with total unilateral vestibular loss (TUVL) show this afternystagmus with a very small slow phase velocity. The SVIN afternystagmus is characterized by a persistent nystagmus with a slow decay after stimulation withdrawal and is associated with dizziness. This distinctive sign in SCD is usually not observed in TUVL patients but only in some other TMWS. Its production likely relies on a cupula deflection secondary to endolymph flow and stimulation of regular discharging neurons by the BCV in SCD but not TUVL patients. It is a simple, specific, robust sign of SCD and TMWS, and its sensitivity is comparable to air-conducted Tullio phenomenon and other compressional tests.
在55%-92%的ct证实为上椎管开裂(SCD)的患者中,当顶点位置受到100Hz的刺激时,颅脑振动会诱发一种过刺激性眼球震颤,最常见的是同侧跳动。颅骨振动诱发眼球震颤(SVIN)试验是第三移动窗综合征(TMWS)患者的骨传导(BC) Tullio现象。在这里,我们描述了获得眼震后的技术线索和程序,以43例SCD患者中55%的患者为例,在100Hz和更高频率下通过骨传导振动(BCV)进行刺激。32例完全性单侧前庭功能丧失(TUVL)患者中,仅有6%的患者表现为眼球震颤后的慢相速度。眼震后SVIN的特征是持续的眼震,刺激退出后缓慢衰减,并伴有头晕。在TUVL患者中通常未观察到SCD的这种独特体征,而仅在其他一些TMWS患者中观察到。在SCD而不是TUVL患者中,它的产生可能依赖于继发于内淋巴流动的丘偏转和BCV对常规放电神经元的刺激。它是一种简单、特异、可靠的SCD和TMWS信号,其灵敏度可与空气传导Tullio现象和其他压缩试验相媲美。
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引用次数: 0
Predictive factors for postoperative outcome after endolymphatic sac surgery. Part 1: Clinical and prognostic STROBE report 内淋巴囊手术后预后的预测因素。第一部分:临床和预后STROBE报告。
IF 2.4 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.anorl.2025.04.002
A. Derieppe, K. Bourget-Aguilar, P. Bordure, G. Michel

Objective

To evaluate preoperative predictive factors 2 years after endolymphatic sac surgery (ESS) in patients with Ménière's disease (MD).

Materials and methods

A retrospective single-center study included patients who underwent ESS between 2015 and 2022, with unilateral MD according to the criteria of the American Academy of Otolaryngology – Head and Neck Surgery (AAO-HNS) as revised in 2015, and resistant to first-line medical treatment. The main study endpoint was the incidence of postoperative vertigo episodes. Secondary endpoints comprised hearing preservation at 2 years and surgical efficacy.

Results

Thirty-eight patients were included. Significant vertigo control was achieved in 63% (n = 24). No predictive factors were identified for vertigo control or improvement in quality of life. Pure-tone and speech audiometric results were preserved at 2 years. Whether the endolymphatic sac was sectioned or not did not significantly impact surgical outcome.

Conclusion

No predictive factors for successful ESS emerged. ESS is a conservative second-line surgical treatment, with key indications for bilateral MD or MD in patients with preserved hearing.
目的:探讨内淋巴囊手术(ESS)后2年msamimni病(MD)患者的术前预测因素。材料和方法:一项回顾性单中心研究纳入了2015年至2022年间接受ESS的患者,根据2015年修订的美国耳鼻喉-头颈外科学会(AAO-HNS)标准,患有单侧MD,对一线药物治疗有抵抗。主要研究终点是术后眩晕发作的发生率。次要终点包括2年听力保存和手术疗效。结果:纳入38例患者。63% (n=24)的眩晕得到显著控制。没有确定眩晕控制或生活质量改善的预测因素。纯音和语音听力测试结果在2岁时保留。内淋巴囊是否切除对手术结果无显著影响。结论:没有预测ESS成功的因素。ESS是一种保守的二线手术治疗,主要指征是双侧MD或听力保留患者的MD。
{"title":"Predictive factors for postoperative outcome after endolymphatic sac surgery. Part 1: Clinical and prognostic STROBE report","authors":"A. Derieppe,&nbsp;K. Bourget-Aguilar,&nbsp;P. Bordure,&nbsp;G. Michel","doi":"10.1016/j.anorl.2025.04.002","DOIUrl":"10.1016/j.anorl.2025.04.002","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate preoperative predictive factors 2<!--> <!-->years after endolymphatic sac surgery (ESS) in patients with Ménière's disease (MD).</div></div><div><h3>Materials and methods</h3><div>A retrospective single-center study included patients who underwent ESS between 2015 and 2022, with unilateral MD according to the criteria of the American Academy of Otolaryngology – Head and Neck Surgery (AAO-HNS) as revised in 2015, and resistant to first-line medical treatment. The main study endpoint was the incidence of postoperative vertigo episodes. Secondary endpoints comprised hearing preservation at 2<!--> <!-->years and surgical efficacy.</div></div><div><h3>Results</h3><div>Thirty-eight patients were included. Significant vertigo control was achieved in 63% (<em>n</em> <!-->=<!--> <!-->24). No predictive factors were identified for vertigo control or improvement in quality of life. Pure-tone and speech audiometric results were preserved at 2<!--> <!-->years. Whether the endolymphatic sac was sectioned or not did not significantly impact surgical outcome.</div></div><div><h3>Conclusion</h3><div>No predictive factors for successful ESS emerged. ESS is a conservative second-line surgical treatment, with key indications for bilateral MD or MD in patients with preserved hearing.</div></div>","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":"142 6","pages":"Pages 281-284"},"PeriodicalIF":2.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suicide attempts in patients treated by total laryngectomy or total pharyngolaryngectomy in France 在法国,接受全喉切除术或全咽切除术的患者的自杀企图。
IF 2.4 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.anorl.2025.03.006
T. Vermeulin , A. Zago , V. Merle , A. Augustynen
{"title":"Suicide attempts in patients treated by total laryngectomy or total pharyngolaryngectomy in France","authors":"T. Vermeulin ,&nbsp;A. Zago ,&nbsp;V. Merle ,&nbsp;A. Augustynen","doi":"10.1016/j.anorl.2025.03.006","DOIUrl":"10.1016/j.anorl.2025.03.006","url":null,"abstract":"","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":"142 6","pages":"Pages 330-331"},"PeriodicalIF":2.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic anterior sinus atelectasis due to middle meatus retraction 慢性前窦不张引起的中鼻窦缩回。
IF 2.4 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.anorl.2025.06.001
M. Veyrat , M.P. Tuset , A. Tran , M. Callet

Introduction

Chronic sinus atelectasis is a rare but classical etiology in maxillary sinusitis. Advanced forms induce orbital deformities. Here we report a case of chronic maxillary-ethmoidal-frontal sinus atelectasis, and detail treatment.

Case report

A 59 year-old man was referred for recurrent right periorbital pain with 2 years’ progression, resistant to local corticosteroid treatment. Clinically, there was right middle turbinate lateralization and ipsilateral enophthalmos. CT showed filling of the right maxillary, anterior ethmoidal and frontal sinuses, with characteristic anterior chronic sinus atelectasis features: retraction of the thinned sinus walls, and decreased sinus volume, confirmed on 3D MRI. Functional ethmoidectomy resolved the obstruction caused by the atelectasis and relieved the patient's pain.

Discussion

This was an original case of chronic sinus atelectasis implicating the middle meatus, with equal involvement of all three anterior sinuses. It highlights the importance of surgical treatment of all the involved sinuses, to stop progression and prevent recurrence.
慢性鼻窦不张是上颌窦炎中一种罕见但典型的病因。严重的形式会导致眼眶畸形。这里我们报告一例慢性上颌-筛-额窦不张,并详细治疗。病例报告:一名59岁男性因复发性右眶周疼痛,进展2年,对局部皮质类固醇治疗有抵抗。临床表现为右中鼻甲偏侧及同侧眼内陷。CT示右侧上颌窦、筛前窦、额窦充盈,伴慢性前窦不张特征性表现:窦壁收缩变薄,体积减小,3D MRI证实。功能性筛壁切除术解决了肺不张引起的梗阻,减轻了患者的疼痛。讨论:这是一例累及中鼻窦的慢性鼻窦不张,同时累及所有三个前鼻窦。它强调了手术治疗所有受累的鼻窦的重要性,以阻止进展和防止复发。
{"title":"Chronic anterior sinus atelectasis due to middle meatus retraction","authors":"M. Veyrat ,&nbsp;M.P. Tuset ,&nbsp;A. Tran ,&nbsp;M. Callet","doi":"10.1016/j.anorl.2025.06.001","DOIUrl":"10.1016/j.anorl.2025.06.001","url":null,"abstract":"<div><h3>Introduction</h3><div><span>Chronic sinus atelectasis is a rare but classical etiology in </span>maxillary sinusitis. Advanced forms induce orbital deformities. Here we report a case of chronic maxillary-ethmoidal-frontal sinus atelectasis, and detail treatment.</div></div><div><h3>Case report</h3><div><span>A 59 year-old man was referred for recurrent right periorbital pain with 2 years’ progression, resistant to local corticosteroid treatment. Clinically, there was right middle </span>turbinate<span> lateralization and ipsilateral enophthalmos<span>. CT showed filling of the right maxillary, anterior ethmoidal and frontal sinuses, with characteristic anterior chronic sinus atelectasis features: retraction of the thinned sinus walls, and decreased sinus volume, confirmed on 3D MRI. Functional ethmoidectomy resolved the obstruction caused by the atelectasis and relieved the patient's pain.</span></span></div></div><div><h3>Discussion</h3><div>This was an original case of chronic sinus atelectasis implicating the middle meatus, with equal involvement of all three anterior sinuses. It highlights the importance of surgical treatment of all the involved sinuses, to stop progression and prevent recurrence.</div></div>","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":"142 6","pages":"Pages 306-308"},"PeriodicalIF":2.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of residual ethmoidal laminae on dupilumab efficacy following endoscopic sinus surgery in patients with chronic rhinosinusitis: A STROBE analysis 慢性鼻窦炎患者内窥镜鼻窦手术后残留筛层对dupilumab疗效的影响:一项STROBE分析。
IF 2.4 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.anorl.2024.11.011
N. Yanagi , T. Takeda , T. Akutsu, M. Maeda, D. Nakashima, K. Omura, E. Mori, N. Otori

Aim

This study aimed to investigate the impact of residual ethmoidal laminae after endoscopic sinus surgery (ESS) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).

Materials and methods

This retrospective cohort included 66 patients with CRSwNP who received 300 mg of dupilumab every 2 weeks for 16 weeks between August 2020 and March 2022. Patients were categorized into the no-lamina or residual-lamina groups based on postoperative sinus computed tomography scans. Clinical parameters, including the Lund-Mackay score (primary endpoint), nasal polyp score, T&T olfactometer threshold, and SNOT-22 scores (secondary endpoints), were assessed at baseline and 16 weeks posttreatment.

Results

Of 66 patients who received dupilumab, 51 met the inclusion criteria. The no-lamina (n = 23) and residual-lamina (n = 28) groups exhibited similar baseline characteristics. At 16 weeks, the Lund-Mackay Score significant improved in the no-lamina group compared with the residual-lamina group (5 ± 4 vs. 9 ± 4; P = 0.004). Non-significant differences were observed in nasal polyp score (2.6 ± 1.6 vs. 3.3 ± 2.0; P = 0.22), T&T olfactometer threshold test score, (3.2 ± 1.8 vs. 3.3 ± 1.4; P = 0.78) SNOT-22 score, (18 ± 11 vs. 24 ± 13; P = 0.15).

Conclusion

This study suggests an association between the absence of residual ethmoidal laminae and an enhanced dupilumab response in CRSwNP. Residual laminae in the anterior ethmoid affect the effectiveness of dupilumab in targeting inflammatory pathways. Meticulous clearance, particularly in the anterior ethmoidal region, optimizes the efficacy of dupilumab. Understanding the influence of residual ethmoidal laminae on dupilumab outcomes is crucial for refining post-ESS treatment strategies for patients with CRSwNP.
目的:探讨慢性鼻窦炎合并鼻息肉(CRSwNP)患者内镜鼻窦手术(ESS)后残余筛层的影响。材料和方法:该回顾性队列包括66例CRSwNP患者,这些患者在2020年8月至2022年3月期间每2周接受300mg dupilumab治疗,共16周。根据术后鼻窦计算机断层扫描结果,将患者分为无椎板组和剩余椎板组。临床参数,包括lnd - mackay评分(主要终点)、鼻息肉评分、T&T嗅觉仪阈值和SNOT-22评分(次要终点),在基线和治疗后16周进行评估。结果:66例接受dupilumab治疗的患者中,51例符合纳入标准。无椎板组(n=23)和剩余椎板组(n=28)表现出相似的基线特征。16周时,无椎板组的Lund-Mackay评分显著提高(5±4比9±4;P = 0.004)。两组鼻息肉评分差异无统计学意义(2.6±1.6∶3.3±2.0;P=0.22), T&T嗅觉阈值测试得分(3.2±1.8∶3.3±1.4;P=0.78) SNOT-22评分,(18±11∶24±13;P = 0.15)。结论:本研究提示在CRSwNP中筛膜残留缺失与dupilumab应答增强之间存在关联。筛前残留的椎板影响dupilumab靶向炎症通路的有效性。细致的清除,特别是筛前区,优化了dupilumab的疗效。了解残余筛叶对dupilumab结果的影响对于改进CRSwNP患者ess后的治疗策略至关重要。
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引用次数: 0
The price of success in surgery 手术成功的代价。
IF 2.4 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2025-11-01 DOI: 10.1016/j.anorl.2025.09.003
E. Babin , E. Lescanne
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引用次数: 0
期刊
European Annals of Otorhinolaryngology-Head and Neck Diseases
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