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Psychometric properties of the revised Eating Disorder Core Beliefs Questionnaire (ED-CBQ-R) in an eating disorder treatment-seeking sample. 修订进食障碍核心信念问卷(ED-CBQ-R)在进食障碍寻求治疗样本中的心理测量特性
IF 3.5 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-11-20 DOI: 10.1080/10640266.2025.2591167
Amaani H Hatoum, Deborah Mitchison, Maree J Abbott, Mandy Goldstein, Christopher Basten, Gabriella Heruc, Christopher Thornton, Marion Roberts, Megan Bray, Amy L Burton

The present study aimed to comprehensively evaluate the psychometric properties and clinical utility of the revised Eating Disorder Core Beliefs Questionnaire (ED-CBQ-R) in a clinical sample of individuals seeking treatment for an eating disorder (ED), as well as to examine potential differences in ED core beliefs across distinct diagnostic groups. Treatment-seeking adults (N =150) were recruited from specialist ED private practices throughout Australia and New Zealand, as a part of the Clinical Quality Registry for Eating Disorder Treatment (the "TrEAT Registry", Australian Register of Clinical Registries: #ACSQHC-ARCR-279). Further, undergraduate data (N = 294) was collected at T1 and T2 (after a four-week interval) to examine test-retest reliability of the ED-CBQ-R. In the treatment-seeking sample, the total ED-CBQ-R, Self-loathing, Unassertive, Demanding and Abandoned subscales displayed good internal consistency, discriminative ability, and the four-factor structure showed acceptable to good fit. Treatment-seeking participants displayed significantly higher scores on all ED-CBQ-R subscales than those in the undergraduate sample. There were no significant differences on the ED-CBQ-R between diagnostic groups, except for the AN-R group displaying higher self-loathing than those with BED. Finally, the ED-CBQ-R demonstrated good test-retest reliability in the undergraduate sample. The outcomes of the present study support the validity, reliability, and clinical utility of the ED-CBQ-R in those seeking treatment for an ED and supports researchers and clinicians in utilising the ED-CBQ-R to identify and monitor critical cognitive targets for treatment and guide clinical decision making.

本研究旨在全面评估修订后的饮食失调核心信念问卷(ED- cbq - r)在寻求饮食失调(ED)治疗的个体临床样本中的心理测量特性和临床应用,并检查不同诊断组之间ED核心信念的潜在差异。从澳大利亚和新西兰的专科ED私人诊所招募寻求治疗的成年人(N =150),作为饮食失调治疗临床质量登记处的一部分(“治疗登记处”,澳大利亚临床登记处:#ACSQHC-ARCR-279)。此外,在T1和T2(间隔四周后)收集本科生数据(N = 294),以检验ED-CBQ-R的重测信度。在寻求治疗样本中,ED-CBQ-R总量表、自我厌恶量表、不自信量表、苛求量表和遗弃量表具有良好的内部一致性和判别能力,四因子结构呈可接受到良好的拟合。寻求治疗的参与者在所有ED-CBQ-R分量表上的得分明显高于本科生样本。ED-CBQ-R在诊断组之间没有显著差异,除了AN-R组比BED组表现出更高的自我厌恶。最后,ED-CBQ-R在大学生样本中表现出良好的重测信度。本研究的结果支持ED- cbq - r在寻求ED治疗的患者中的有效性、可靠性和临床实用性,并支持研究人员和临床医生利用ED- cbq - r识别和监测治疗的关键认知目标并指导临床决策。
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引用次数: 0
Acceptability and feasibility of utilizing telehealth to deliver evidence-based treatments for eating disorders in children and adolescents. 利用远程保健为儿童和青少年饮食失调提供循证治疗的可接受性和可行性。
IF 3.5 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-11-03 DOI: 10.1080/10640266.2025.2580717
Sam Leder, James D Lock, Brittany E Matheson

This acceptability and feasibility study utilized a mixed methods approach to examine patient and clinician perspectives on telehealth across multiple eating disorder presentations and evidence-based treatment modalities. Youth ages 6-19 received psychotherapy for eating disorders in an outpatient specialty clinic. The Telehealth Expectations Questionnaire (TEQ) assessed baseline expectations of telehealth. Satisfaction with telehealth was assessed monthly through the Telehealth Satisfaction Questionnaire (TSQ). Experiences with telehealth were measured at end of treatment through the Telehealth Usability Questionnaire (TUQ) and Implementation of Telehealth Treatment Questionnaire. The Eating Disorder Examination Questionnaire (EDE-Q) measured clinical improvement. Use of telehealth services was associated with clinically significant reductions in eating disorder symptoms. Qualitatively, patients and families reported advantages of telehealth, specifically saving time and ease of use, and identified disadvantages, including technological difficulties and feeling disconnected from therapists. Clinicians reported benefits of telehealth, such as insight into the home environment, and challenges, such as managing distractions and reading body language. Clinicians identified specific adaptations for telehealth when conducting one-on-one time with patients and taking weights. The perspectives of youth, families, and clinicians highlight important clinical considerations in the utilization of telehealth to promote accessible and effective care for eating disorders.

这项可接受性和可行性研究采用混合方法方法,检查患者和临床医生对多种饮食失调表现和循证治疗方式的远程医疗的看法。6-19岁的青少年在门诊专科诊所接受饮食失调的心理治疗。远程医疗期望问卷(TEQ)评估了远程医疗的基线期望。通过远程医疗满意度问卷(TSQ)每月评估远程医疗满意度。在治疗结束时,通过远程医疗可用性问卷(TUQ)和远程医疗治疗问卷的实施来测量远程医疗的体验。饮食失调检查问卷(ed - q)测量临床改善情况。使用远程保健服务与饮食失调症状的临床显著减少有关。从质量上讲,患者和家属报告了远程保健的优点,特别是节省时间和易于使用,并指出了缺点,包括技术困难和感觉与治疗师脱节。临床医生报告了远程医疗的好处,例如对家庭环境的洞察,以及挑战,例如管理分心和阅读肢体语言。临床医生在与患者进行一对一的时间和称重时确定了远程医疗的具体适应性。青年、家庭和临床医生的观点强调了利用远程医疗促进对饮食失调的可及性和有效护理的重要临床考虑。
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引用次数: 0
Examining the roles of reward sensitivity and difficulties in emotion regulation in relation to low-restraint binge eating. 研究奖赏敏感性和情绪调节困难对低节制暴食的影响。
IF 3.5 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-11-01 Epub Date: 2024-10-20 DOI: 10.1080/10640266.2024.2411476
Laura Lapadat, Angela Gao, Ege Bicaker, Sarah E Racine

Leading treatments for binge eating target dietary restraint, but up to 35% of the people with binge eating report low restraint. This study examined the roles of reward sensitivity and emotion dysregulation in relation to low-restraint binge eating. Women with binge eating (low-restraint: n = 22; high-restraint: n = 69) and controls (n = 49) completed self-report measures of generalized reward sensitivity and emotion dysregulation and a picture-viewing task assessing craving and pleasure for high-calorie food. As expected, food-related craving and emotion dysregulation were greater in the clinical than in the control group, but no differences emerged between high- and low-restraint binge eating groups. However, correlational analyses found that, within the clinical group, the number of restraint days related to greater anticipatory sensitivity for generalized rewards and lower pleasure ratings of food. Results suggest that emotion dysregulation characterizes both high- and low-restraint binge eating. As self-reported food liking was linked with lower restraint, greater enjoyment of palatable foods may uniquely contribute to low-restraint binge eating. Increasing emphasis on emotion regulation and food-related reward sensitivity may enhance treatment outcomes for individuals with low-restraint binge eating.

针对暴饮暴食的主要治疗方法以饮食节制为目标,但多达 35% 的暴饮暴食患者表示节制程度很低。本研究探讨了奖赏敏感性和情绪失调在低克制暴食中的作用。患有暴食症的妇女(低克制:22 人;高克制:69 人)和对照组妇女(49 人)完成了关于奖赏敏感性和情绪失调的自我报告测量,以及一项评估对高热量食物的渴望和快感的图片浏览任务。不出所料,临床组对食物的渴望和情绪失调程度高于对照组,但高克制暴食组和低克制暴食组之间没有差异。然而,相关分析发现,在临床组中,克制天数与对一般奖励的预期敏感度和对食物的愉悦度较低有关。结果表明,情绪失调是高克制暴食和低克制暴食的特征。由于自我报告的食物喜好与较低的克制度有关,因此更喜欢美味食物可能是导致低克制度暴食的独特原因。加强对情绪调节和食物相关奖赏敏感性的重视可能会提高低克制暴食患者的治疗效果。
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引用次数: 0
Online dialectical behavior therapy for binge eating disorder: an open trial. 针对暴饮暴食症的在线辩证行为疗法:一项公开试验。
IF 3.5 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-11-01 Epub Date: 2024-10-28 DOI: 10.1080/10640266.2024.2421047
Maria Karapatsia, Chara Tzavara, Ioannis Michopoulos, Fragiskos Gonidakis

The purpose of the present study was to examine the efficacy of online Dialectical Behavior Therapy for Binge Eating Disorder (DBT-BED) in reducing eating psychopathology and investigate the factors that influence the severity and frequency of binge eating. Seventy-three individuals seeking treatment for BED participated in 20 two-hour group sessions. Participants completed the Emotional Eating Scale (EES), Binge Eating Scale (BES), and Eating Disorder Examination Questionnaire (EDE-Q) before and after the treatment and at three- and six-month follow-ups. Results from 58 participants were analyzed. The study results indicated a significant decrease in objective binge eating (OBE) days, as well as in all EES, BES, and EDE-Q subscales (except the Restraint subscale), and global EDE-Q score at the end of treatment and follow-ups. Moreover, the Body Mass Index (BMI) reduced at the end of treatment and during the follow-up period. Except for the Restraint subscale, more OBE days were linked with higher EES, BES, and EDE-Q scores. Overall, the study suggests that online DBT-BED is an effective approach to treating Binge Eating Disorder (BED) for individuals who cannot receive in-person therapy. Further research is necessary to compare the efficacy of online DBT-BED with other interventions.

本研究旨在考察在线暴食症辩证行为疗法(DBT-BED)在减少饮食心理病理学方面的疗效,并调查影响暴食严重程度和频率的因素。73 名寻求暴食症治疗的患者参加了 20 节两小时的小组课程。参与者在治疗前后以及三个月和六个月的随访中填写了情绪化进食量表(EES)、暴食量表(BES)和进食障碍检查问卷(EDE-Q)。对 58 名参与者的结果进行了分析。研究结果表明,在治疗结束和随访时,客观暴食(OBE)天数、所有EES、BES和EDE-Q分量表(克制分量表除外)以及EDE-Q总分均有明显下降。此外,身体质量指数(BMI)在治疗结束时和随访期间都有所下降。除约束分量表外,更多的 OBE 天数与更高的 EES、BES 和 EDE-Q 分数相关。总的来说,这项研究表明,对于无法接受现场治疗的人来说,在线 DBT-BED 是治疗暴食症(BED)的有效方法。有必要开展进一步研究,以比较在线 DBT-BED 与其他干预措施的疗效。
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引用次数: 0
Building the representation of male mental health professionals in eating disorder treatment. 建立男性心理健康专业人员在饮食失调治疗中的代表性。
IF 3.5 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-11-01 Epub Date: 2024-09-19 DOI: 10.1080/10640266.2024.2405291
Kyle T Ganson, Douglas W Bunnell

Male mental health professionals (e.g. social workers, psychologists) are a minority of providers in eating disorder treatment spaces, and there is a drastic need to increase their representation in this clinical area. This Last Word outlines the barriers that impede male mental health professionals from specializing in eating disorder treatment, such as masculine gender norms, and provides four specific recommendations to enhance training, hiring, retention, and the development of male mental health professionals in the treatment of people with eating disorders. These recommendations include, developing gender awareness, specialized training, talking about gender, and gender and relationships. Building the representation of male mental health professionals in eating disorder treatment may reduce stigma and myths about these disorders and have positive impacts on clients across genders.

男性心理健康专业人士(如社会工作者、心理学家)在饮食失调治疗领域的提供者中占少数,因此急需增加他们在这一临床领域的代表性。这篇 "最后的话 "概述了阻碍男性心理健康专业人员专门从事饮食失调治疗的障碍,如男性的性别规范,并提出了四项具体建议,以加强男性心理健康专业人员在饮食失调患者治疗方面的培训、聘用、留用和发展。这些建议包括:培养性别意识、专业培训、谈论性别以及性别与人际关系。培养男性心理健康专业人员在饮食失调症治疗中的代表性,可以减少对这些疾病的偏见和误解,并对不同性别的患者产生积极影响。
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引用次数: 0
The relationship between emotion regulation difficulties and eating disorder outcomes: a longitudinal examination in a residential eating disorder treatment facility. 情绪调节困难与进食障碍结果之间的关系:在进食障碍住院治疗机构进行的纵向研究。
IF 3.5 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-11-01 Epub Date: 2024-10-16 DOI: 10.1080/10640266.2024.2416331
Hannah B Sawyer, Olivia M Clancy, Marielle M Gomez, Ian Cero, April R Smith, Tiffany A Brown, Tracy K Witte

Eating disorders (EDs) are associated with numerous comorbidities and deleterious outcomes (e.g. medical complications, high rates of death by suicide). The complexities of EDs are further compounded by treatment dropout, poor treatment outcomes, and relapse. One way to better understand these complexities is to investigate broad, transdiagnostic risk factors that contribute to the etiology and maintenance of EDs, such as emotion regulation (ER) difficulties. We longitudinally tested the relationship between ER difficulties and ED outcomes in a sample of 101 female ED patients in a southeastern U.S. residential ED treatment facility. Consistent with hypothesis, there were significant improvements in both ER difficulties and eating pathology from admission to discharge. Further, improvement in ER difficulties was associated with improvements in eating pathology. These findings further substantiate the role of ER difficulties in eating disorders and provide further evidence for the relationship between ER difficulties and eating pathology among residential eating disorder patients.

饮食失调症(ED)与多种并发症和有害结果(如医疗并发症、高自杀死亡率)相关。辍治、治疗效果不佳和复发进一步加剧了饮食失调症的复杂性。要想更好地理解这些复杂性,一种方法是调查导致 ED 病因和维持的广泛、跨诊断风险因素,如情绪调节(ER)困难。我们对美国东南部一家ED住院治疗机构的101名女性ED患者样本进行了纵向测试,以了解情绪调节障碍与ED结果之间的关系。与假设相符的是,从入院到出院,情绪障碍和饮食病理学均有显著改善。此外,急诊室困难的改善与饮食病理学的改善相关。这些发现进一步证实了急诊室困难在进食障碍中的作用,并进一步证明了住院进食障碍患者的急诊室困难与进食病理之间的关系。
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引用次数: 0
Psychotropic medication prescribed for children and young people with eating disorders in mental health in-patient services: a quality improvement programme. 在精神健康住院服务中为患有饮食紊乱症的儿童和青少年开具的精神药物:一项质量改进计划。
IF 3.5 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-11-01 Epub Date: 2024-10-27 DOI: 10.1080/10640266.2024.2418157
David Branford, Anne Webster, Teresa Randon, David Gill, Kirsten Peebles

The aims of this quality improvement programme were to enable providers of mental health in-patient services for children and young people in England to review their prescribing practice alongside the views and experiences of children, young people and their parent carers. Three online tools were developed. First was a medication census tool to be completed by provider clinicians to capture prescribing practices around psychotropic medication. The two other online tools were questionnaires that provided an opportunity for inpatient children and young people and their parent carers to express their views of the medication. 193 children and young people had a primary diagnosis of eating disorders. Antidepressants were the most widely prescribed (56%), followed by antipsychotics (41%), benzodiazepines, and antihistamines as sedatives (18%) and hypnotics (11%). Of those receiving regular psychotropic medications, 67% were prescribed two or more. Both the children and young people and their parent carers expressed concerns about the high level of psychotropic medication, the number of prn administrations, the number of psychotropic medications prescribed and the extent of side effects. Psychotropic medications are widely prescribed both on a regular and on a prn basis for children and young people with eating disorders in mental health in-patient services.

这项质量改进计划的目的是让英格兰儿童和青少年精神健康住院服务的提供者能够根据儿童、青少年及其家长照护者的意见和经验来审查他们的处方做法。开发了三种在线工具。第一种是药物普查工具,由提供服务的临床医生填写,以了解精神药物的处方实践。另外两个在线工具是调查问卷,为住院儿童和青少年及其家长照护者提供了一个表达他们对药物治疗看法的机会。有 193 名儿童和青少年被初步诊断为进食障碍。抗抑郁药是最常用的处方药(56%),其次是抗精神病药(41%)、苯二氮卓类药物、作为镇静剂的抗组胺药(18%)和催眠药(11%)。在接受常规精神药物治疗的患者中,67%的人被处方两种或两种以上的药物。儿童和青少年及其家长照护者都对精神药物的高用量、长期用药次数、处方精神药物的数量以及副作用的程度表示担忧。在精神健康住院服务中,有饮食失调症的儿童和青少年被广泛开具精神药物处方,既有常规处方,也有长期处方。
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引用次数: 0
Peer mentors' experiences of delivering peer support for individuals with eating disorders: giving back and supporting processes of change. 同伴导师为饮食失调患者提供同伴支持的经验:回馈和支持改变的过程。
IF 3.5 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-11-01 Epub Date: 2024-11-19 DOI: 10.1080/10640266.2024.2420419
Andrea LaMarre, Lori Wozney, Nicole Obeid, Sonia Kumar, Shaleen Jones, Gina Dimitropoulos, Jennifer Couturier

Peer support is a promising approach to increasing hope, engagement, and connection for those with eating disorders (EDs). Emerging literature explores peer mentors' experiences of providing support, suggesting that mentors often benefit from providing peer support, particularly when well trained and supervised. We conducted semi-structured interviews or focus groups with 15 individuals providing peer support (one-on-one, group, or chat) to individuals with EDs. We identified 3 themes using reflexive thematic analysis (RTA) through a critical realist lens. Participants emphasized the importance of ongoing training and support to help them deliver high-quality peer support. They highlighted the importance of value-alignment in this work in terms of organizational valuing of lived experience and alignment with social justice. Participants reflected on how doing this work contributed to a sense of "giving back" and providing the kind of support they wished they had experienced. Providing peer support was described as emotion work; a challenging and rewarding experience for peer mentors. Findings carry implications for integrating peer support into the continuum of care for EDs, providing insight into approaches that can support peer support delivery in a way that promotes safety for those providing and receiving it.

对于饮食失调(ED)患者来说,同伴支持是增加希望、参与和联系的一种很有前途的方法。新出现的文献探讨了同伴指导者提供支持的经验,表明指导者通常能从提供同伴支持中获益,尤其是在经过良好培训和监督的情况下。我们对 15 名为进食障碍患者提供同伴支持(一对一、小组或聊天)的人员进行了半结构化访谈或焦点小组讨论。我们通过批判现实主义视角,采用反思性主题分析(RTA)确定了 3 个主题。参与者强调了持续培训和支持对帮助他们提供高质量同伴支持的重要性。他们强调,在这项工作中,组织对生活经验的重视以及与社会正义的一致非常重要。参与者反思了从事这项工作如何有助于产生一种 "回馈 "感,以及如何提供他们希望自己经历过的那种支持。提供同伴支持被描述为一种情感工作;对同伴指导者来说,这是一种富有挑战性和回报性的经历。研究结果对将同伴支持纳入急诊室的持续护理具有重要意义,为支持同伴支持的提供方法提供了启示,从而促进提供者和接受者的安全。
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引用次数: 0
Measuring eating disorders in Autistic people: a proposal for future research. 测量自闭症患者的饮食失调:未来研究建议。
IF 3.5 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-11-01 Epub Date: 2024-10-16 DOI: 10.1080/10640266.2024.2416340
Phaedra Longhurst, Emy Nimbley, Elizabeth H Evans, Keren MacLennan, Karri Gillespie-Smith, Fiona Duffy

While diagnostic pathways for identifying Autism in eating disorder (ED) populations have been developed, the field continues to lack validated psychometric tools to measure EDs for use in the Autistic population. Many commonly used measures for EDs potentially lack validity and reliability in the Autistic population limiting theoretical and practical advancements in the field. This paper outlines current conflicts in autism and ED research and how these can be addressed through psychometric methodology. We discuss: (1) the lack of differentiation between ED pathology and Autistic eating behaviours, as well as the limited inclusion of autism-specific mechanisms in existing tools; (2) the subsequent theoretical and practical implications for researchers, clinicians, and Autistic people; and (3) future directions for psychometric research. Scholars are encouraged to employ participatory designs with autistic people before carefully considering which analytical strategies are used in the Autistic population.

虽然饮食失调症(ED)人群中自闭症的诊断途径已经开发出来,但该领域仍然缺乏有效的心理测量工具来测量自闭症人群中的饮食失调症。许多常用的 ED 测量方法在自闭症人群中可能缺乏有效性和可靠性,这限制了该领域的理论和实践进步。本文概述了当前自闭症和教育问题研究中的冲突,以及如何通过心理测量方法解决这些问题。我们将讨论(1) ED 病理和自闭症饮食行为之间缺乏区分,以及现有工具中对自闭症特定机制的包含有限;(2) 随后对研究人员、临床医生和自闭症患者的理论和实践影响;以及 (3) 心理测量学研究的未来方向。我们鼓励学者们在仔细考虑自闭症人群使用何种分析策略之前,先与自闭症患者一起采用参与式设计。
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引用次数: 0
Absolute and relative outcomes of cognitive behavior therapy for eating disorders in adults: a meta-analysis. 成人饮食失调认知行为疗法的绝对和相对疗效:一项荟萃分析。
IF 3.5 3区 医学 Q2 PSYCHIATRY Pub Date : 2025-11-01 Epub Date: 2024-11-08 DOI: 10.1080/10640266.2024.2421057
Pim Cuijpers, Mathias Harrer, Clara Miguel, Aaron Keshen, Eirini Karyotaki, Jake Linardon

Cognitive-behavioral therapy (CBT) is the best examined treatment for eating disorders. However, previous meta-analyses of cognitive-behavioral therapy have not examined absolute outcomes, which are important from a clinical perspective. We updated a meta-analysis and conducted new searches in PubMed, Embase, PsycINFO and CINAHL. We included randomized trials comparing CBT with control conditions in adults with a diagnosed eating disorder. We used random effects models in all analyses. We included 36 trials with 44 comparisons between CBT and controls (2,809 participants), 22 trials on binge eating disorder (BED), 11 on bulimia nervosa (BN), and three on anorexia nervosa and mixed disorders. The overall effect of CBT compared to controls was g = 0.88 (95% CI: 0.71; 1.04), with high heterogeneity (I2 = 74; 95% CI: 65; 81; PI: -0.06; 1.81) and no significant difference between BED and BN. Effects were smaller studies with low risk of bias. The absolute abstinence rate was 0.36 (95% CI: 0.31; 0.43) for CBT and 0.10 (95% CI: 0.08; 0.12) in controls. CBT is probably effective in the treatment of bulimia nervosa and binge-eating disorder, but there is also a large group of patients who do not respond sufficiently.

认知行为疗法(CBT)是治疗饮食失调症的最佳疗法。然而,以往对认知行为疗法进行的荟萃分析并未对绝对疗效进行研究,而从临床角度来看,绝对疗效是非常重要的。我们更新了一项荟萃分析,并在 PubMed、Embase、PsycINFO 和 CINAHL 中进行了新的检索。我们纳入了对已确诊患有饮食失调症的成人进行 CBT 与对照条件比较的随机试验。我们在所有分析中都使用了随机效应模型。我们纳入了 36 项试验,其中有 44 项是对 CBT 和对照组(2809 名参与者)进行比较,22 项试验涉及暴饮暴食症(BED),11 项涉及神经性贪食症(BN),3 项涉及神经性厌食症和混合性障碍。与对照组相比,CBT 的总体效果为 g = 0.88 (95% CI: 0.71; 1.04),异质性较高 (I2 = 74; 95% CI: 65; 81; PI: -0.06; 1.81),BED 和 BN 之间无显著差异。影响较小的研究偏倚风险较低。CBT 的绝对戒断率为 0.36 (95% CI: 0.31; 0.43),对照组为 0.10 (95% CI: 0.08; 0.12)。 CBT 在治疗神经性贪食症和暴饮暴食症方面效果显著,但也有很大一部分患者反应不佳。
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引用次数: 0
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