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Linear Dimensional Accuracy in Maxillomandibular Records: A Comparative Study of Scannable and Transparent Materials.
IF 3.1 4区 医学 Q1 Medicine Pub Date : 2025-02-22 DOI: 10.12659/MSM.947265
Mohammed E Sayed, Bandar M A Al-Makramani, Praveen Gangadharappa, Mohammed M Al Moaleem, Loay E Najmi, Faisal A A Daghreeri, Rayan A Nahari, Mohammad Alamri, Nisreen Nabiel Hassan, Mai Almarzouki, Saad Saleh AlResayes, Ahid Amer Alshahrani, Saeed M Alqahtani, Khurshid Mattoo

BACKGROUND Maxillomandibular relationship records facilitate patient stomatognathic information transfer to dental laboratories, but new bite registration materials (BRMs) lack scientific evidence on linear dimensional accuracy. This in vitro investigation compared linear dimensional accuracy of 6 commercial scannable and transparent BRMs with a typical BRM at 1 h. MATERIAL AND METHODS Seven American Dental Association (ADA)-approved BRMs were categorized into 1 control and 2 experimental groups: control: Occlufast Rock; scannable group: Occlufast CAD, Virtual CADBite, and Flexitime Bite; and transparent group: Maxill Bite, Charmflex Bite, and Defend ClearBite. The study used modified ADA specification no. 19 to standardize bite registration record samples, which were examined using a stereomicroscope to compare with control group and standard die measurements. Median, interquartile range, and median rank scores were used for statistical interpretation. One-way ANOVA (Kruskal-Wallis rank test) and multiple-comparison Dunn test with Bonferroni correction compared between and within group differences at the probability P value ≤0.05. RESULTS The median linear differences varied in scannable, -0.06 (0.24%) to -0.11mm (0.44%), and transparent, -0.06 (0.24%) to -0.07 (0.28%), BRMs, with transparent BRMs showing more linear accuracy than scannable BRMs. A statistically significant difference from control at 1 h was observed for 3 different commercial brands. All transparent BRMs exhibited markedly reduced linear discrepancies, compared with the standard BRM (P<0.05). CONCLUSIONS All BRMs at 1 h showed a reduced linear dimensions, indicating shrinkage. All investigated BRMs demonstrated clinically acceptable linear discrepancies, with transparent BRMs exhibiting less change than scannable BRMs.

{"title":"Linear Dimensional Accuracy in Maxillomandibular Records: A Comparative Study of Scannable and Transparent Materials.","authors":"Mohammed E Sayed, Bandar M A Al-Makramani, Praveen Gangadharappa, Mohammed M Al Moaleem, Loay E Najmi, Faisal A A Daghreeri, Rayan A Nahari, Mohammad Alamri, Nisreen Nabiel Hassan, Mai Almarzouki, Saad Saleh AlResayes, Ahid Amer Alshahrani, Saeed M Alqahtani, Khurshid Mattoo","doi":"10.12659/MSM.947265","DOIUrl":"https://doi.org/10.12659/MSM.947265","url":null,"abstract":"<p><p>BACKGROUND Maxillomandibular relationship records facilitate patient stomatognathic information transfer to dental laboratories, but new bite registration materials (BRMs) lack scientific evidence on linear dimensional accuracy. This in vitro investigation compared linear dimensional accuracy of 6 commercial scannable and transparent BRMs with a typical BRM at 1 h. MATERIAL AND METHODS Seven American Dental Association (ADA)-approved BRMs were categorized into 1 control and 2 experimental groups: control: Occlufast Rock; scannable group: Occlufast CAD, Virtual CADBite, and Flexitime Bite; and transparent group: Maxill Bite, Charmflex Bite, and Defend ClearBite. The study used modified ADA specification no. 19 to standardize bite registration record samples, which were examined using a stereomicroscope to compare with control group and standard die measurements. Median, interquartile range, and median rank scores were used for statistical interpretation. One-way ANOVA (Kruskal-Wallis rank test) and multiple-comparison Dunn test with Bonferroni correction compared between and within group differences at the probability P value ≤0.05. RESULTS The median linear differences varied in scannable, -0.06 (0.24%) to -0.11mm (0.44%), and transparent, -0.06 (0.24%) to -0.07 (0.28%), BRMs, with transparent BRMs showing more linear accuracy than scannable BRMs. A statistically significant difference from control at 1 h was observed for 3 different commercial brands. All transparent BRMs exhibited markedly reduced linear discrepancies, compared with the standard BRM (P<0.05). CONCLUSIONS All BRMs at 1 h showed a reduced linear dimensions, indicating shrinkage. All investigated BRMs demonstrated clinically acceptable linear discrepancies, with transparent BRMs exhibiting less change than scannable BRMs.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"31 ","pages":"e947265"},"PeriodicalIF":3.1,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Term Outcomes of Implanon in Managing Adenomyosis: A 3-Year Prospective Study.
IF 3.1 4区 医学 Q1 Medicine Pub Date : 2025-02-21 DOI: 10.12659/MSM.945972
Na Jiao, Jie Wang, Hongxin Mu, Qiwei Qi

BACKGROUND Adenomyosis, which involves the presence of endometrial tissue within the uterine muscle, leads to chronic pelvic pain and heavy menstrual bleeding, creating challenges for contraception. The subdermal contraceptive implant Implanon presents a potential solution due to its long-acting properties. This study evaluates the efficacy, safety, and user satisfaction of Implanon in patients with adenomyosis, aiming to enhance understanding of its clinical benefits in this demographic. MATERIAL AND METHODS A prospective study over three years at Qingdao Women and Children's Hospital followed 124 women with and without adenomyosis after they received Implanon implants. Follow-up visits at 10 days, 3 months, 6 months, 1 year, 2 years, and 3 years post-implantation assessed adverse events, implant removals, and patient satisfaction. A survival analysis was conducted to investigate the influence of adenomyosis on the continuation of the implant. RESULTS All 124 patients completed the study with a 100% follow-up and contraception rate. Bleeding disorders, excluding amenorrhea, were the most common adverse events, affecting 52.42% of participants at 3 months and decreasing to 8.43% at 36 months. The incidence was notably lower in those with adenomyosis, with a significant decline seen from 6 to 12 months after implantation. The implant continuation rates at 1 year, 2 years, and 3 years were 75.81%, 66.94% and 54.84%, respectively. Women with adenomyosis had a lower risk of removal (hazard ratio=0.62) and higher satisfaction and were more inclined to opt for reimplantation upon expiration. CONCLUSIONS Implanon is a relatively effective and safe contraceptive, particularly for women with adenomyosis. Counseling on possible bleeding-related side effects is crucial for maintaining satisfaction and optimizing implant use.

{"title":"Long-Term Outcomes of Implanon in Managing Adenomyosis: A 3-Year Prospective Study.","authors":"Na Jiao, Jie Wang, Hongxin Mu, Qiwei Qi","doi":"10.12659/MSM.945972","DOIUrl":"https://doi.org/10.12659/MSM.945972","url":null,"abstract":"<p><p>BACKGROUND Adenomyosis, which involves the presence of endometrial tissue within the uterine muscle, leads to chronic pelvic pain and heavy menstrual bleeding, creating challenges for contraception. The subdermal contraceptive implant Implanon presents a potential solution due to its long-acting properties. This study evaluates the efficacy, safety, and user satisfaction of Implanon in patients with adenomyosis, aiming to enhance understanding of its clinical benefits in this demographic. MATERIAL AND METHODS A prospective study over three years at Qingdao Women and Children's Hospital followed 124 women with and without adenomyosis after they received Implanon implants. Follow-up visits at 10 days, 3 months, 6 months, 1 year, 2 years, and 3 years post-implantation assessed adverse events, implant removals, and patient satisfaction. A survival analysis was conducted to investigate the influence of adenomyosis on the continuation of the implant. RESULTS All 124 patients completed the study with a 100% follow-up and contraception rate. Bleeding disorders, excluding amenorrhea, were the most common adverse events, affecting 52.42% of participants at 3 months and decreasing to 8.43% at 36 months. The incidence was notably lower in those with adenomyosis, with a significant decline seen from 6 to 12 months after implantation. The implant continuation rates at 1 year, 2 years, and 3 years were 75.81%, 66.94% and 54.84%, respectively. Women with adenomyosis had a lower risk of removal (hazard ratio=0.62) and higher satisfaction and were more inclined to opt for reimplantation upon expiration. CONCLUSIONS Implanon is a relatively effective and safe contraceptive, particularly for women with adenomyosis. Counseling on possible bleeding-related side effects is crucial for maintaining satisfaction and optimizing implant use.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"31 ","pages":"e945972"},"PeriodicalIF":3.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predicting Cerebral Small Vessel Disease Burden Based on Thromboelastography in Patients with Acute Ischemic Stroke: A Pilot Study.
IF 3.1 4区 医学 Q1 Medicine Pub Date : 2025-02-20 DOI: 10.12659/MSM.946303
Min Xia, DaiZong Wu, NengWei Yu, GuoXiang Huang

BACKGROUND This study aimed to investigate the relationship between the coagulation function measured by thromboelastography (TEG) in patients with acute ischemic stroke (AIS) and total burden of cerebral small vessel disease (CSVD), to further establish a nomogram tool based on regular clinical risk factors and TEG, to conveniently predict the risk of high-grade white matter hyperintensities (WMH) and CSVD burden in AIS patients. MATERIAL AND METHODS A cross-sectional study included 143 AIS patients who underwent TEG tests and 3.0T head MRI scans after admission. They were grouped according to total burden CSVD score and WMH Fazekas score. Differences in regular clinical data (RCD), TEG, and conventional coagulation tests (CCT) between groups were compared. Three sets of logistic regression models were established: RCD model, and models combining RCD with TEG and CCT respectively, to evaluate their predictive performance for WMH and SVD in patients with AIS. RESULTS Univariate analysis revealed age, hypertension, stroke history, fibrinogen, and TEG indicators maximum amplitude, Angle, K, and coagulation index were risk factors for increased WMH Fazekas score and CSVD burden in patients with AIS (OR>1, P<0.05). Logistic regression model combining RCD and TEG had a higher AUC value in predicting WMH (Fazekas score ≥2) and SVD (SVD burden score ≥3). CONCLUSIONS TEG parameters of patients with AIS are related to CSVD burden and its imaging features. Based on regular clinical risk factors, TEG can provide additional predictive information on the severity of WMHs and the burden of CSVD in patients with AIS.

{"title":"Predicting Cerebral Small Vessel Disease Burden Based on Thromboelastography in Patients with Acute Ischemic Stroke: A Pilot Study.","authors":"Min Xia, DaiZong Wu, NengWei Yu, GuoXiang Huang","doi":"10.12659/MSM.946303","DOIUrl":"https://doi.org/10.12659/MSM.946303","url":null,"abstract":"<p><p>BACKGROUND This study aimed to investigate the relationship between the coagulation function measured by thromboelastography (TEG) in patients with acute ischemic stroke (AIS) and total burden of cerebral small vessel disease (CSVD), to further establish a nomogram tool based on regular clinical risk factors and TEG, to conveniently predict the risk of high-grade white matter hyperintensities (WMH) and CSVD burden in AIS patients. MATERIAL AND METHODS A cross-sectional study included 143 AIS patients who underwent TEG tests and 3.0T head MRI scans after admission. They were grouped according to total burden CSVD score and WMH Fazekas score. Differences in regular clinical data (RCD), TEG, and conventional coagulation tests (CCT) between groups were compared. Three sets of logistic regression models were established: RCD model, and models combining RCD with TEG and CCT respectively, to evaluate their predictive performance for WMH and SVD in patients with AIS. RESULTS Univariate analysis revealed age, hypertension, stroke history, fibrinogen, and TEG indicators maximum amplitude, Angle, K, and coagulation index were risk factors for increased WMH Fazekas score and CSVD burden in patients with AIS (OR>1, P<0.05). Logistic regression model combining RCD and TEG had a higher AUC value in predicting WMH (Fazekas score ≥2) and SVD (SVD burden score ≥3). CONCLUSIONS TEG parameters of patients with AIS are related to CSVD burden and its imaging features. Based on regular clinical risk factors, TEG can provide additional predictive information on the severity of WMHs and the burden of CSVD in patients with AIS.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"31 ","pages":"e946303"},"PeriodicalIF":3.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Procedure Dynamics in Transfemoral vs Transradial Cerebral Angiography: A Retrospective Study.
IF 3.1 4区 医学 Q1 Medicine Pub Date : 2025-02-19 DOI: 10.12659/MSM.947603
Tae-Sung Kim, Jinhoo Seok, Haewon Roh, Wonki Yoon, Taek-Hyun Kwon, Hyunjun Jo

BACKGROUND Cerebral angiography, although invasive, remains the most accurate diagnostic tool for neurovascular diseases. While transfemoral cerebral angiography (TFCA) is the conventional approach, transradial cerebral angiography (TRCA) has gained interest due to potential benefits, such as reduced hematoma risk and shorter recovery times. However, procedure times and influencing factors remain debated. This retrospective study from a single center aimed to compare procedure time in 100 patients undergoing conventional TFCA and 93 undergoing TRCA. MATERIAL AND METHODS This single-center retrospective study included 193 patients who underwent 4-vessel cerebral angiography from January to December 2023. TFCA and TRCA were performed by experienced neurosurgeons. TRCA involved radial artery access with collateral circulation assessment (modified Allen's and Barbeau's tests), and TFCA used femoral artery access with standard techniques. Clinical data, including puncture times and radiation exposure, were collected. Logistic regression identified factors influencing prolonged procedure times (>20 minutes). RESULTS Procedure times for TFCA and TRCA were similar (median: 20.00 minutes vs 24.50 minutes, p=0.139), though TRCA showed longer puncture times (median: 10.00 vs 10.00 minutes, p=0.001). Radiation exposure was comparable (421.00 milliGray (mGy) vs 418.50 mGy, p=0.530). Hypertension (OR: 2.255, p=0.011) and aortic arch tortuosity (OR: 3.881, p=0.002) significantly influenced prolonged procedures. CONCLUSIONS TRCA offers a safe and effective alternative to TFCA for diagnostic cerebral angiography, with comparable procedure times and radiation exposure. While patient-specific factors, such as hypertension and aortic arch tortuosity, influence procedure duration, TRCA provides benefits in patient comfort and recovery. These findings support the broader use of TRCA in diagnostic settings.

{"title":"Procedure Dynamics in Transfemoral vs Transradial Cerebral Angiography: A Retrospective Study.","authors":"Tae-Sung Kim, Jinhoo Seok, Haewon Roh, Wonki Yoon, Taek-Hyun Kwon, Hyunjun Jo","doi":"10.12659/MSM.947603","DOIUrl":"https://doi.org/10.12659/MSM.947603","url":null,"abstract":"<p><p>BACKGROUND Cerebral angiography, although invasive, remains the most accurate diagnostic tool for neurovascular diseases. While transfemoral cerebral angiography (TFCA) is the conventional approach, transradial cerebral angiography (TRCA) has gained interest due to potential benefits, such as reduced hematoma risk and shorter recovery times. However, procedure times and influencing factors remain debated. This retrospective study from a single center aimed to compare procedure time in 100 patients undergoing conventional TFCA and 93 undergoing TRCA. MATERIAL AND METHODS This single-center retrospective study included 193 patients who underwent 4-vessel cerebral angiography from January to December 2023. TFCA and TRCA were performed by experienced neurosurgeons. TRCA involved radial artery access with collateral circulation assessment (modified Allen's and Barbeau's tests), and TFCA used femoral artery access with standard techniques. Clinical data, including puncture times and radiation exposure, were collected. Logistic regression identified factors influencing prolonged procedure times (>20 minutes). RESULTS Procedure times for TFCA and TRCA were similar (median: 20.00 minutes vs 24.50 minutes, p=0.139), though TRCA showed longer puncture times (median: 10.00 vs 10.00 minutes, p=0.001). Radiation exposure was comparable (421.00 milliGray (mGy) vs 418.50 mGy, p=0.530). Hypertension (OR: 2.255, p=0.011) and aortic arch tortuosity (OR: 3.881, p=0.002) significantly influenced prolonged procedures. CONCLUSIONS TRCA offers a safe and effective alternative to TFCA for diagnostic cerebral angiography, with comparable procedure times and radiation exposure. While patient-specific factors, such as hypertension and aortic arch tortuosity, influence procedure duration, TRCA provides benefits in patient comfort and recovery. These findings support the broader use of TRCA in diagnostic settings.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"31 ","pages":"e947603"},"PeriodicalIF":3.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retracted: IC-2 Suppresses Proliferation and Induces Apoptosis of Bladder Cancer Cells via the Wnt/β-Catenin Pathway.
IF 3.1 4区 医学 Q1 Medicine Pub Date : 2025-02-19 DOI: 10.12659/MSM.948581
Lingfeng Wu, Shunliang He, Yi He, Xueping Wang, Linfeng Lu

This publication has been retracted by the Editor due to the identification of non-original figure images and manuscript content that raise concerns regarding the credibility and originality of the study and the manuscript. Reference: Lingfeng Wu, Shunliang He, Yi He, Xueping Wang, Linfeng Lu. IC-2 Suppresses Proliferation and Induces Apoptosis of Bladder Cancer Cells via the Wnt/ß-Catenin Pathway. Med Sci Monit, 2018; 24: 8074-8080. DOI: 10.12659/MSM.910742.

{"title":"Retracted: IC-2 Suppresses Proliferation and Induces Apoptosis of Bladder Cancer Cells via the Wnt/β-Catenin Pathway.","authors":"Lingfeng Wu, Shunliang He, Yi He, Xueping Wang, Linfeng Lu","doi":"10.12659/MSM.948581","DOIUrl":"https://doi.org/10.12659/MSM.948581","url":null,"abstract":"<p><p>This publication has been retracted by the Editor due to the identification of non-original figure images and manuscript content that raise concerns regarding the credibility and originality of the study and the manuscript. Reference: Lingfeng Wu, Shunliang He, Yi He, Xueping Wang, Linfeng Lu. IC-2 Suppresses Proliferation and Induces Apoptosis of Bladder Cancer Cells via the Wnt/ß-Catenin Pathway. Med Sci Monit, 2018; 24: 8074-8080. DOI: 10.12659/MSM.910742.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"31 ","pages":"e948581"},"PeriodicalIF":3.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hydrogels in Oral Disease Management: A Review of Innovations in Drug Delivery and Tissue Regeneration.
IF 3.1 4区 医学 Q1 Medicine Pub Date : 2025-02-18 DOI: 10.12659/MSM.946122
Li Dongwen, Man Dapeng, Yu Jiazhi, Li Xiaoguang

The oral cavity is an open and complicated structure with a variety of factors affecting topical oral medications. The complicated physical and chemical surroundings of the oral cavity can influence the action of free drugs. Thus, the drug delivery system can serve as a support structure or carrier. Hydrogels are prospective tissue engineering biomaterials that demonstrate immense potential for oral tissue regeneration and drug delivery. Hydrogels are crosslinked polymer chains with a 3-dimensional network structure that can take up larger volumes of liquid and have a soft, porous structure that closely resembles living tissue. Hydrogels protect the active drug from systemic and topical elimination, increase the bioavailability and absorption into cells, and release or modify the therapeutic drug release immediately after dosing. In this review, we introduce the classification of hydrogels, introduce the application of hydrogels in oral diseases (periodontal disease, endodontics, oral mucosal disease, alveolar surgery, oral cancer, maxillofacial bone defects, and oral implantation), summarize the synthesis methods and the applications of hydrogels, and discuss the possible directions of the future development of hydrogels, which will provide a new idea for the formulation and production of a more advantageous and efficient topical oral drug delivery system.

{"title":"Hydrogels in Oral Disease Management: A Review of Innovations in Drug Delivery and Tissue Regeneration.","authors":"Li Dongwen, Man Dapeng, Yu Jiazhi, Li Xiaoguang","doi":"10.12659/MSM.946122","DOIUrl":"10.12659/MSM.946122","url":null,"abstract":"<p><p>The oral cavity is an open and complicated structure with a variety of factors affecting topical oral medications. The complicated physical and chemical surroundings of the oral cavity can influence the action of free drugs. Thus, the drug delivery system can serve as a support structure or carrier. Hydrogels are prospective tissue engineering biomaterials that demonstrate immense potential for oral tissue regeneration and drug delivery. Hydrogels are crosslinked polymer chains with a 3-dimensional network structure that can take up larger volumes of liquid and have a soft, porous structure that closely resembles living tissue. Hydrogels protect the active drug from systemic and topical elimination, increase the bioavailability and absorption into cells, and release or modify the therapeutic drug release immediately after dosing. In this review, we introduce the classification of hydrogels, introduce the application of hydrogels in oral diseases (periodontal disease, endodontics, oral mucosal disease, alveolar surgery, oral cancer, maxillofacial bone defects, and oral implantation), summarize the synthesis methods and the applications of hydrogels, and discuss the possible directions of the future development of hydrogels, which will provide a new idea for the formulation and production of a more advantageous and efficient topical oral drug delivery system.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"31 ","pages":"e946122"},"PeriodicalIF":3.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retrospective Study to Compare Injury Patterns and Associations in 170 Patients Following Electric Scooter and Bicycle Accidents in Turkey.
IF 3.1 4区 医学 Q1 Medicine Pub Date : 2025-02-17 DOI: 10.12659/MSM.947155
Ümit Şimşek, Tuğçen Demircan

BACKGROUND Bicycle use has long been encouraged in urban areas in Turkey as a safe and sustainable mode of transport, supported by dedicated bicycle paths and traffic regulations. However, the recent rise in the popularity of electric scooters (e-scooters) has introduced new safety concerns, leading to injuries among riders, pedestrians, and other road users. This retrospective study compared injury patterns and associated factors in 170 patients involved in e-scooter and bicycle accidents in Eskişehir, Turkey. MATERIAL AND METHODS This study included 170 patients (54 e-scooter users and 116 bicycle users) involved in accidents between April 2021 and December 2023. Data were retrospectively obtained from hospital records and forensic reports of patients referred by the prosecutor's office to Eskişehir Osmangazi University. Ethical approval was secured, and all analyses were performed using SPSS version 27. RESULTS E-scooter users were significantly younger than bicycle users (mean age: 21.96 vs 30.03 years, P=0.001) and included a higher proportion of female riders (24.1% vs 12%, P=0.019). Motor vehicle collisions were more common in e-scooter accidents (68.5% vs 48.3%, P<0.001), and alcohol consumption was significantly higher among e-scooter users (18.5% vs 4.3%, P=0.006). While head injuries were more frequent among e-scooter users, fractures and dislocations were predominantly observed in bicycle users (P=0.020). CONCLUSIONS The findings from this study underscore distinct safety concerns between e-scooter and bicycle riders, emphasizing the urgent need for targeted safety interventions to mitigate the rising risk of urban e-scooter accidents.

{"title":"Retrospective Study to Compare Injury Patterns and Associations in 170 Patients Following Electric Scooter and Bicycle Accidents in Turkey.","authors":"Ümit Şimşek, Tuğçen Demircan","doi":"10.12659/MSM.947155","DOIUrl":"10.12659/MSM.947155","url":null,"abstract":"<p><p>BACKGROUND Bicycle use has long been encouraged in urban areas in Turkey as a safe and sustainable mode of transport, supported by dedicated bicycle paths and traffic regulations. However, the recent rise in the popularity of electric scooters (e-scooters) has introduced new safety concerns, leading to injuries among riders, pedestrians, and other road users. This retrospective study compared injury patterns and associated factors in 170 patients involved in e-scooter and bicycle accidents in Eskişehir, Turkey. MATERIAL AND METHODS This study included 170 patients (54 e-scooter users and 116 bicycle users) involved in accidents between April 2021 and December 2023. Data were retrospectively obtained from hospital records and forensic reports of patients referred by the prosecutor's office to Eskişehir Osmangazi University. Ethical approval was secured, and all analyses were performed using SPSS version 27. RESULTS E-scooter users were significantly younger than bicycle users (mean age: 21.96 vs 30.03 years, P=0.001) and included a higher proportion of female riders (24.1% vs 12%, P=0.019). Motor vehicle collisions were more common in e-scooter accidents (68.5% vs 48.3%, P<0.001), and alcohol consumption was significantly higher among e-scooter users (18.5% vs 4.3%, P=0.006). While head injuries were more frequent among e-scooter users, fractures and dislocations were predominantly observed in bicycle users (P=0.020). CONCLUSIONS The findings from this study underscore distinct safety concerns between e-scooter and bicycle riders, emphasizing the urgent need for targeted safety interventions to mitigate the rising risk of urban e-scooter accidents.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"31 ","pages":"e947155"},"PeriodicalIF":3.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical Efficacy in Varicocele Ligation with Ephedrine-Assisted Blood Pressure Control.
IF 3.1 4区 医学 Q1 Medicine Pub Date : 2025-02-16 DOI: 10.12659/MSM.946234
Jingkai Wang, Jian Wang, Hailuo Wang, Bo Chen, Xitao Wang, Peng Xu, Ruoran Zhang, Qing Liang, Kun Pang

BACKGROUND Surgery for varicocele has evolved to include microscopy-guided methods for spermatic vein ligation. This retrospective observational clinical study included 52 patients undergoing microscopic spermatic veins ligation (MSVL) for varicocele to compare outcomes in patients with and without medically induced elevation of blood pressure (EBP) aimed at improving identification of the testicular arteries (TAs). MATERIAL AND METHODS Twenty-five patients underwent MSVL and 27 patients underwent MSVL with ephedrine (6.52±1.28 mg) to briefly increase BP to 140-160 mmHg. The duration of the procedure, the number of TAs preserved, the number of spermatic veins ligated, the incidence of arterial injuries, the incidence of complications, the incidence of recurrence, and the preoperative and 6-month postoperative semen parameters were compared between the 2 groups. RESULTS The operative time in the EBP group (36.48±4.53 min) was significantly shorter than that in the non-elevated blood pressure (NEBP) group (50.40±6.46 min) (P<0.001). The number of preserved TAs in the EBP group (1.33±0.48) was significantly higher than that in the NEBP group (0.96±0.45) (P=0.006). Postoperative semen parameters in both the EBP and NEBP groups were significantly improved compared with the preoperative period (both P<0.001). There was no significant difference between the 2 groups in the number of spermatic veins ligated, incidence of arterial injury, incidence of complications, recurrence rate, or semen parameters at 6 months postoperatively (all P>0.05). CONCLUSIONS During MSVL, the use of ephedrine to increase BP to 140-160 mmHg can assist surgeons in safely and effectively identifying and preserving the TAs, thus improving the efficacy of the procedure.

{"title":"Surgical Efficacy in Varicocele Ligation with Ephedrine-Assisted Blood Pressure Control.","authors":"Jingkai Wang, Jian Wang, Hailuo Wang, Bo Chen, Xitao Wang, Peng Xu, Ruoran Zhang, Qing Liang, Kun Pang","doi":"10.12659/MSM.946234","DOIUrl":"10.12659/MSM.946234","url":null,"abstract":"<p><p>BACKGROUND Surgery for varicocele has evolved to include microscopy-guided methods for spermatic vein ligation. This retrospective observational clinical study included 52 patients undergoing microscopic spermatic veins ligation (MSVL) for varicocele to compare outcomes in patients with and without medically induced elevation of blood pressure (EBP) aimed at improving identification of the testicular arteries (TAs). MATERIAL AND METHODS Twenty-five patients underwent MSVL and 27 patients underwent MSVL with ephedrine (6.52±1.28 mg) to briefly increase BP to 140-160 mmHg. The duration of the procedure, the number of TAs preserved, the number of spermatic veins ligated, the incidence of arterial injuries, the incidence of complications, the incidence of recurrence, and the preoperative and 6-month postoperative semen parameters were compared between the 2 groups. RESULTS The operative time in the EBP group (36.48±4.53 min) was significantly shorter than that in the non-elevated blood pressure (NEBP) group (50.40±6.46 min) (P<0.001). The number of preserved TAs in the EBP group (1.33±0.48) was significantly higher than that in the NEBP group (0.96±0.45) (P=0.006). Postoperative semen parameters in both the EBP and NEBP groups were significantly improved compared with the preoperative period (both P<0.001). There was no significant difference between the 2 groups in the number of spermatic veins ligated, incidence of arterial injury, incidence of complications, recurrence rate, or semen parameters at 6 months postoperatively (all P>0.05). CONCLUSIONS During MSVL, the use of ephedrine to increase BP to 140-160 mmHg can assist surgeons in safely and effectively identifying and preserving the TAs, thus improving the efficacy of the procedure.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"31 ","pages":"e946234"},"PeriodicalIF":3.1,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Impact of Kinesio Taping and Post-Isometric Muscle Relaxation on Pain and Myofascial Mechanics in Chronic Low Back Pain: A Randomized Clinical Trial.
IF 3.1 4区 医学 Q1 Medicine Pub Date : 2025-02-15 DOI: 10.12659/MSM.945376
Tomasz Sipko, Bernadetta Berger-Pasternak, Adam Paluszak

BACKGROUND This study aimed to evaluate and compare the effects of Kinesio taping (KT), with or without tension (Placebo), and post-isometric muscle relaxation (PIR) on pain intensity and the mechanical properties of myofascial tissues in chronic low back pain (LBP) patients. MATERIAL AND METHODS Study participants (n=64; females, n=34; males, n=30; mean age 41.9 years), were randomly assigned to 1 of the 3 intervention groups. The numerical rating scale (NRS) was used to assess pain intensity at rest, the Oswestry Disability Index was used to estimate the level of disability, and the MyotonPRO© device was used to measure tension, stiffness, and relaxation in the erector spinae on both sides of the lumbar spine. The examinations were performed before the intervention, after interventions, and at 7-day follow-up (RCT Id: ACTRN12624000121561). RESULTS Pain and level of disability were reduced for all groups (P<0.01). In addition, post hoc analysis of the KT group showed significant increases in tension and stiffness of the erector spinae and significantly decreased relaxation between the pre-intervention and follow-up measurements, but only on the contralateral side (P<0.01). CONCLUSIONS KT with or without tape tension and PIR had similar effects in decreasing the level of resting pain and disability. Pain reduction was not related to changes in the mechanical properties of the soft tissue. It can be concluded that the KT with or without tape tension or PIR were mainly analgesic effects, and should be used as a combined therapy in LBP patients.

{"title":"Comparative Impact of Kinesio Taping and Post-Isometric Muscle Relaxation on Pain and Myofascial Mechanics in Chronic Low Back Pain: A Randomized Clinical Trial.","authors":"Tomasz Sipko, Bernadetta Berger-Pasternak, Adam Paluszak","doi":"10.12659/MSM.945376","DOIUrl":"10.12659/MSM.945376","url":null,"abstract":"<p><p>BACKGROUND This study aimed to evaluate and compare the effects of Kinesio taping (KT), with or without tension (Placebo), and post-isometric muscle relaxation (PIR) on pain intensity and the mechanical properties of myofascial tissues in chronic low back pain (LBP) patients. MATERIAL AND METHODS Study participants (n=64; females, n=34; males, n=30; mean age 41.9 years), were randomly assigned to 1 of the 3 intervention groups. The numerical rating scale (NRS) was used to assess pain intensity at rest, the Oswestry Disability Index was used to estimate the level of disability, and the MyotonPRO© device was used to measure tension, stiffness, and relaxation in the erector spinae on both sides of the lumbar spine. The examinations were performed before the intervention, after interventions, and at 7-day follow-up (RCT Id: ACTRN12624000121561). RESULTS Pain and level of disability were reduced for all groups (P<0.01). In addition, post hoc analysis of the KT group showed significant increases in tension and stiffness of the erector spinae and significantly decreased relaxation between the pre-intervention and follow-up measurements, but only on the contralateral side (P<0.01). CONCLUSIONS KT with or without tape tension and PIR had similar effects in decreasing the level of resting pain and disability. Pain reduction was not related to changes in the mechanical properties of the soft tissue. It can be concluded that the KT with or without tape tension or PIR were mainly analgesic effects, and should be used as a combined therapy in LBP patients.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"31 ","pages":"e945376"},"PeriodicalIF":3.1,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11837403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pre- and Post-Surgical MRI Analysis of Levator Ani in Pelvic Organ Prolapse Patients: A Single-Center Study.
IF 3.1 4区 医学 Q1 Medicine Pub Date : 2025-02-14 DOI: 10.12659/MSM.945993
Haifeng Wang, Zhen Hua Gao, Heng Zhang, Mei Chen, Yan Li, Jihong Shen

BACKGROUND This single-center study involved 33 women diagnosed with pelvic organ prolapse (POP), aiming to evaluate the levator ani muscle (LAM) using pre- and post-surgery magnetic resonance imaging (MRI). MATERIAL AND METHODS MRI data of 33 women were analyzed before and after POP surgery. Diagnoses used the Pelvic Organ Prolapse Quantification (POP-Q) system, including 10 cases of stage II, 5 of stage III, and 18 of stage IV with pelvic organ prolapse. All participants underwent pelvic floor reconstruction surgery. Morphological parameters, including the levator hiatus's length, width, area, and the distance between the LAMs and the pubic symphysis's inferior point, were assessed before and after surgery. RESULTS Significant pre- and post-surgery differences were observed in the levator hiatus's shape, length, width, and area, and the distance between levator ani and pubic symphysis in both static and Valsalva states. CONCLUSIONS We found structural changes in the LAM morphology in women with POP, as assessed by MRI, suggesting potential improvements in clinical function.

{"title":"Pre- and Post-Surgical MRI Analysis of Levator Ani in Pelvic Organ Prolapse Patients: A Single-Center Study.","authors":"Haifeng Wang, Zhen Hua Gao, Heng Zhang, Mei Chen, Yan Li, Jihong Shen","doi":"10.12659/MSM.945993","DOIUrl":"10.12659/MSM.945993","url":null,"abstract":"<p><p>BACKGROUND This single-center study involved 33 women diagnosed with pelvic organ prolapse (POP), aiming to evaluate the levator ani muscle (LAM) using pre- and post-surgery magnetic resonance imaging (MRI). MATERIAL AND METHODS MRI data of 33 women were analyzed before and after POP surgery. Diagnoses used the Pelvic Organ Prolapse Quantification (POP-Q) system, including 10 cases of stage II, 5 of stage III, and 18 of stage IV with pelvic organ prolapse. All participants underwent pelvic floor reconstruction surgery. Morphological parameters, including the levator hiatus's length, width, area, and the distance between the LAMs and the pubic symphysis's inferior point, were assessed before and after surgery. RESULTS Significant pre- and post-surgery differences were observed in the levator hiatus's shape, length, width, and area, and the distance between levator ani and pubic symphysis in both static and Valsalva states. CONCLUSIONS We found structural changes in the LAM morphology in women with POP, as assessed by MRI, suggesting potential improvements in clinical function.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"31 ","pages":"e945993"},"PeriodicalIF":3.1,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Medical Science Monitor
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