Pub Date : 2023-09-12DOI: 10.30591/pjif.v12i3.5759
Wahyuningsih Marda Sari
Acute respiratory infection (ARI) has become a common disease that we often encounter in society, especially in children under five and is still a major health problem in Indonesia. The irrational use of antibiotics causes many problems that arise and is a global threat to public health, especially in bacterial resistance to antibiotics. This study aims to determine the rationality of using antibiotics which includes the right indication, the right drug, the right patient and the right dose based on the Pharmaceutical care guidelines, 2005 and to find out the rationality of using antibiotics using the Gyssens method compared to the PMK guidelines, 2021 and DIH, 2019.The research method used is descriptive method and data collected retrospectively. The population of this study was all outpatient data with a diagnosis of acute respiratory infection at Dr. Moewardi Surakarta in 2022. The sample for this study was all medical record data of ARI patients during January - December 2022 adjusted for inclusion criteria.The results of the rationality of the use of antibiotics obtained the right indication (51%), the right dose (35%), the right drug (51%), and the right patient (100%) and the results of the rationality of using antibiotics using the Gyssens method showed the results for category 0 (32%) , category IIa (4%), category IIb (3%) and category V (61%). Keywords -- Antibiotics, Acute Respiratory Infections, Gyssens Method, Rationality
{"title":"ANALISIS RASIONALITAS PENGGUNAAN ANTIBIOTIK PADA PASIEN INFEKSI SALURAN PERNAPASAN AKUT (ISPA) RAWAT JALAN DI RSUD DR. MOEWARDI SURAKARTA","authors":"Wahyuningsih Marda Sari","doi":"10.30591/pjif.v12i3.5759","DOIUrl":"https://doi.org/10.30591/pjif.v12i3.5759","url":null,"abstract":"Acute respiratory infection (ARI) has become a common disease that we often encounter in society, especially in children under five and is still a major health problem in Indonesia. The irrational use of antibiotics causes many problems that arise and is a global threat to public health, especially in bacterial resistance to antibiotics. This study aims to determine the rationality of using antibiotics which includes the right indication, the right drug, the right patient and the right dose based on the Pharmaceutical care guidelines, 2005 and to find out the rationality of using antibiotics using the Gyssens method compared to the PMK guidelines, 2021 and DIH, 2019.The research method used is descriptive method and data collected retrospectively. The population of this study was all outpatient data with a diagnosis of acute respiratory infection at Dr. Moewardi Surakarta in 2022. The sample for this study was all medical record data of ARI patients during January - December 2022 adjusted for inclusion criteria.The results of the rationality of the use of antibiotics obtained the right indication (51%), the right dose (35%), the right drug (51%), and the right patient (100%) and the results of the rationality of using antibiotics using the Gyssens method showed the results for category 0 (32%) , category IIa (4%), category IIb (3%) and category V (61%). Keywords -- Antibiotics, Acute Respiratory Infections, Gyssens Method, Rationality","PeriodicalId":489418,"journal":{"name":"Parapemikir: Jurnal Ilmiah Farmasi","volume":"117 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135825592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-11DOI: 10.30591/pjif.v12i3.5845
Nanang Ardianto, Fika Maharani, Aldesra Fitri, Hana Fieky Cintikashalma Verlyndika
{"title":"HUBUNGAN TINGKAT PENGETAHUAN TERHADAP KETEPATAN PENGGUNAAN OBAT ANALGESIK PADA SWAMEDIKASI NYERI DI DESA PANDANREJO MALANG","authors":"Nanang Ardianto, Fika Maharani, Aldesra Fitri, Hana Fieky Cintikashalma Verlyndika","doi":"10.30591/pjif.v12i3.5845","DOIUrl":"https://doi.org/10.30591/pjif.v12i3.5845","url":null,"abstract":"","PeriodicalId":489418,"journal":{"name":"Parapemikir: Jurnal Ilmiah Farmasi","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135982504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Masalah kesehatan yang paling umum terjadi pada anak adalah demam. Demam merupakan proses alami tubuh untuk melawan infeksi yang terjadi ketika suhu tubuh melebihi suhu normal (38°C). Meski beberapa kasus demam bisa diobati tanpa intervensi medis, demam tinggi bisa berdampak buruk pada anak. Swamedikasi yaitu usaha yang sering dilakukan masyarakat untuk dalam mengatasi keluhan atau gejala penyakit seperti demam. penelitian ini bersifat kuantitatif non experimental dengan metode korelatif. Pada penelitian menggunakan kuisioner. Pada penelitian ini guna penentuan sampel menggunakan teknik “probability sampling” yaitu proses pengambilan populasi ke dalam sastra. Dari populasi kemudian di bagi kedalam sebuah sampel.Dalam penelitian ini populasi orang tua di SD Gunung rejo 02 Malang sebanyak 229 dari perhitungan di peroleh 80 responden. Berdasarkan hasil penelitian yang dilakukan di SD Gunungrejo 02 Malang, dengan jumlah responden 80. Dengan presentasi 100% semua wanita (ibu). diketahui usia 57.9% banyaknya responden berusua 30-40 tahun. tingkat pendidikan ibu, mayoritas SMA presentase 48,75%. Responden pengetahuan yang baik dengan nilai 68,75%. Penanganan 85% baik. Pada uji hubungan antara dua variable pengetahuan dan penanganan swamedikasi demam pada anak di dapatkan nilai r hitung uji korelasi sebesar 0,701 dengan nilai signifikan (p value) sebesar 0,000 Artinya terdapat hubungan yang signifikan antara hubungan pengetahuan dan penangan swamedikasi demam pada anak.
{"title":"HUBUNGAN PENGETAHUAN ORANG TUA SWAMEDIKASI DAN PENANGANAN DEMAM PADA ANAK DI SDN GUNUNGREJO 02 MALANG","authors":"Wiwin Rohma Maulidah, Nanang Ardianto, Novyananda Salmasfattah, Fika Maharani","doi":"10.30591/pjif.v12i3.5849","DOIUrl":"https://doi.org/10.30591/pjif.v12i3.5849","url":null,"abstract":"Masalah kesehatan yang paling umum terjadi pada anak adalah demam. Demam merupakan proses alami tubuh untuk melawan infeksi yang terjadi ketika suhu tubuh melebihi suhu normal (38°C). Meski beberapa kasus demam bisa diobati tanpa intervensi medis, demam tinggi bisa berdampak buruk pada anak. Swamedikasi yaitu usaha yang sering dilakukan masyarakat untuk dalam mengatasi keluhan atau gejala penyakit seperti demam. penelitian ini bersifat kuantitatif non experimental dengan metode korelatif. Pada penelitian menggunakan kuisioner. Pada penelitian ini guna penentuan sampel menggunakan teknik “probability sampling” yaitu proses pengambilan populasi ke dalam sastra. Dari populasi kemudian di bagi kedalam sebuah sampel.Dalam penelitian ini populasi orang tua di SD Gunung rejo 02 Malang sebanyak 229 dari perhitungan di peroleh 80 responden. Berdasarkan hasil penelitian yang dilakukan di SD Gunungrejo 02 Malang, dengan jumlah responden 80. Dengan presentasi 100% semua wanita (ibu). diketahui usia 57.9% banyaknya responden berusua 30-40 tahun. tingkat pendidikan ibu, mayoritas SMA presentase 48,75%. Responden pengetahuan yang baik dengan nilai 68,75%. Penanganan 85% baik. Pada uji hubungan antara dua variable pengetahuan dan penanganan swamedikasi demam pada anak di dapatkan nilai r hitung uji korelasi sebesar 0,701 dengan nilai signifikan (p value) sebesar 0,000 Artinya terdapat hubungan yang signifikan antara hubungan pengetahuan dan penangan swamedikasi demam pada anak.","PeriodicalId":489418,"journal":{"name":"Parapemikir: Jurnal Ilmiah Farmasi","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135938496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-11DOI: 10.30591/pjif.v12i3.5706
Finda Hamidah, Yustisia Dian Advistasari, Wulan Kartika Sari
{"title":"COST OF ILLNESS PASIEN DIABETES MELLITUS TIPE 2 JKN NON PBI DI INSTALASI RAWAT INAP RUMAH SAKIT ISLAM SULTAN AGUNG SEMARANG PERIODE JANUARI-DESEMBER 2022","authors":"Finda Hamidah, Yustisia Dian Advistasari, Wulan Kartika Sari","doi":"10.30591/pjif.v12i3.5706","DOIUrl":"https://doi.org/10.30591/pjif.v12i3.5706","url":null,"abstract":"","PeriodicalId":489418,"journal":{"name":"Parapemikir: Jurnal Ilmiah Farmasi","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135982549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-09DOI: 10.30591/pjif.v12i3.5163
Luthfi Hidayat Maulana, Rizki Noor Prastyono, Syaiful Prayogi, Erni Murniningsih, M. Zidan Alfarikhi
Reactive Oxygen Species (ROS) is a radical which is a by-product of metabolic processes. An imbalance between the number of free radicals and the amount of endogenous antioxidants can cause oxidative stress and cause problems for body cells that can cause various metabolic diseases or other degenerative diseases. Exogenous antioxidants can be chemical compounds resulting from synthesis or materials derived from nature that can inhibit the oxidation process. Phenol group compounds can be used as antioxidants. Salam plants (Syzygium polyanthum) and ketapang (Terminalia catappa L.) are rich in phenols. In vitro antioxidant testing using other methods such as DPPH (2,2-Diphenyl-1-Pikrylhidrazyl), in silico, molecular docking was carried out by targeting the heme oxygenase-1 (HO-1) protein to test antioxidant activity with analysis showing binding and strengthening evidence of impending chemical interactions. Based on in vitro testing, ketapang leaf extract has better antioxidant activity compared to bay leaf extract, with an IC50 value of 6.631 and the in silico results of the constituent compounds of ketapang leaves have the best docking value, namely compound 14 with a value of -88.18. Both of these test results reinforce each other
{"title":"UJI AKTIVITAS ANTIOKSIDAN Syzygium polyanthum DAN Terminalia catappa L. SECARA IN VITRO DAN IN SILICO","authors":"Luthfi Hidayat Maulana, Rizki Noor Prastyono, Syaiful Prayogi, Erni Murniningsih, M. Zidan Alfarikhi","doi":"10.30591/pjif.v12i3.5163","DOIUrl":"https://doi.org/10.30591/pjif.v12i3.5163","url":null,"abstract":"Reactive Oxygen Species (ROS) is a radical which is a by-product of metabolic processes. An imbalance between the number of free radicals and the amount of endogenous antioxidants can cause oxidative stress and cause problems for body cells that can cause various metabolic diseases or other degenerative diseases. Exogenous antioxidants can be chemical compounds resulting from synthesis or materials derived from nature that can inhibit the oxidation process. Phenol group compounds can be used as antioxidants. Salam plants (Syzygium polyanthum) and ketapang (Terminalia catappa L.) are rich in phenols. In vitro antioxidant testing using other methods such as DPPH (2,2-Diphenyl-1-Pikrylhidrazyl), in silico, molecular docking was carried out by targeting the heme oxygenase-1 (HO-1) protein to test antioxidant activity with analysis showing binding and strengthening evidence of impending chemical interactions. Based on in vitro testing, ketapang leaf extract has better antioxidant activity compared to bay leaf extract, with an IC50 value of 6.631 and the in silico results of the constituent compounds of ketapang leaves have the best docking value, namely compound 14 with a value of -88.18. Both of these test results reinforce each other","PeriodicalId":489418,"journal":{"name":"Parapemikir: Jurnal Ilmiah Farmasi","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136193120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-06DOI: 10.30591/pjif.v12i3.5746
Aulia Nur Rahmawati, Eka Wisnu Kusuma, Dwi Saryanti
{"title":"PENETAPAN KADAR FLAVONOID EKSTRAK AIR BUAH JAMBU BIJI MERAH (Psidium guajava Linn)","authors":"Aulia Nur Rahmawati, Eka Wisnu Kusuma, Dwi Saryanti","doi":"10.30591/pjif.v12i3.5746","DOIUrl":"https://doi.org/10.30591/pjif.v12i3.5746","url":null,"abstract":"","PeriodicalId":489418,"journal":{"name":"Parapemikir: Jurnal Ilmiah Farmasi","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135204991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bunga kenanga memiliki minyak atsiri yang memiliki aktivitas sebagai antibakteri. Untuk meningkatkan kepraktisan dalam penggunaan, minyak atsiri bunga kenanga diformulasikan dalam bentuk sediaan facemist. Penelitian ini bertujuan mengetahui randemen minyak atsiri dari bunga kenanga, mengetahui komponen minyak atsiri yang diidentifikasi dengan GC-MS, mengetahui evaluasi fisik sediaan facemist dan mengetahui aktivitas antibakteri facemist terhadap Staphylococcus aureus ATCC 25923. Bunga kenanga (Cananga odorata) didestilasi menggunakan metode destilasi uap. Minyak atsiri diidentifikasi senyawanya menggunakan alat GC-MS dan diformulasikan kedalam sediaan facemist dan dilakukan uji aktivitas antibakteri terhadap bakteri Staphylococcus aureus ATCC 25923. Hasil dari penelitian didapatkan randemen minyak atsiri bunga kenanga sebesar 0,33%. Hasil dari identifikasi komponen minyak atsiri terdapat 4 senyawa tertinggi β-Caryophyllene, Germacrene-D, Benzyl benzoate dan α-caryophyllene. Hasil uji aktivitas antibakteri sediaan facemist pada formula 1 (10%), formula 2 (15%) dan formula 3 (20%) dengan daya hambat rata-rata sebesar 9,26 mm, 11,16 mm dan 11,83 mm. Hasil evaluasi fisik dari keempat formulasi sediaan facemist menujukkan semua nya memenuhi standar mutu fisik yang baik dan berdasarkan hasil uji iritasi sediaan facemist tidak menunjukkan adanya iritasi pada kulit.
{"title":"FORMULASI SEDIAAN FACEMIST ANTIBAKTERIAL DAN IDENTIFIKASI MINYAK ATSIRI BUNGA KENANGA (Cananga odorata) MENGGUNAKAN GC-MS","authors":"Annisa Nurlaila Sari, Bangkit Riska Permata, Desy Ayu Irma Permatasari","doi":"10.30591/pjif.v12i3.5524","DOIUrl":"https://doi.org/10.30591/pjif.v12i3.5524","url":null,"abstract":"Bunga kenanga memiliki minyak atsiri yang memiliki aktivitas sebagai antibakteri. Untuk meningkatkan kepraktisan dalam penggunaan, minyak atsiri bunga kenanga diformulasikan dalam bentuk sediaan facemist. Penelitian ini bertujuan mengetahui randemen minyak atsiri dari bunga kenanga, mengetahui komponen minyak atsiri yang diidentifikasi dengan GC-MS, mengetahui evaluasi fisik sediaan facemist dan mengetahui aktivitas antibakteri facemist terhadap Staphylococcus aureus ATCC 25923. Bunga kenanga (Cananga odorata) didestilasi menggunakan metode destilasi uap. Minyak atsiri diidentifikasi senyawanya menggunakan alat GC-MS dan diformulasikan kedalam sediaan facemist dan dilakukan uji aktivitas antibakteri terhadap bakteri Staphylococcus aureus ATCC 25923. Hasil dari penelitian didapatkan randemen minyak atsiri bunga kenanga sebesar 0,33%. Hasil dari identifikasi komponen minyak atsiri terdapat 4 senyawa tertinggi β-Caryophyllene, Germacrene-D, Benzyl benzoate dan α-caryophyllene. Hasil uji aktivitas antibakteri sediaan facemist pada formula 1 (10%), formula 2 (15%) dan formula 3 (20%) dengan daya hambat rata-rata sebesar 9,26 mm, 11,16 mm dan 11,83 mm. Hasil evaluasi fisik dari keempat formulasi sediaan facemist menujukkan semua nya memenuhi standar mutu fisik yang baik dan berdasarkan hasil uji iritasi sediaan facemist tidak menunjukkan adanya iritasi pada kulit.","PeriodicalId":489418,"journal":{"name":"Parapemikir: Jurnal Ilmiah Farmasi","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135204463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：