Pub Date : 2021-06-01DOI: 10.23736/S0392-0488.19.06376-4
V. Panasiti, M. Barone, R. Coppola, V. Devirgiliis, V. Roberti, P. Persichetti, S. Carotti, S. Morini
BACKGROUND Estrogens play a key role in the skin: they are associated with an increased production of melanin, proliferation of melanocytes, increased skin thickness and increased cutaneous vascularization. Spitz and Reed nevi are acquired melanocytic lesions that generally develop during childhood or adolescence, a period of changes in sex hormones background. Our study project aimed at investigating, through immunohistochemical analysis, the expression levels of ERß receptors and their expression patterns (cytoplasmic or nuclear) in Spitz and Reed nevi. METHODS In our study we collected a total of 86 melanocytic lesions of patients: of these, 16 were common nevi, 23 were Spitz nevi, 18 were Reed nevi and 29 were melanomas. Expression curves for estrogen receptors were constructed using the Kaplan-Meier method and compared using a log-rank test.Statistical analysis was performed using MedCalc®. Immunohistochemical analysis on all histological sections of nevi and melanomas was performed to evaluate the expression levels of of ERß and their expression patterns (cytoplasmic or nuclear). The agreement between the operators was calculated using Fleiss κ values. RESULTS Correlation between immunoreactivity for the β-estrogen receptor and the sex of patients with Spitz and Reed nevi: immunoreactivity was higher in male patients. Correlation between β-estrogen receptor immunoreactivity and patient age for Spitz and Reed nevi: No statistically significant correlation was observed. Correlation between immunoreactivity for the β-estrogen receptor and histotype: Spitz and Reed nevi showed a high intensity, while in common nevi and in melanomas the immunoreactive was low. Correlation between receptor immunoreactivity for β estrogens and Breslow thickness in melanomas: Breslow thickness of non-immunoreactive melanomas for ERβ was much higher than those showing high immunoreactivity for this reeptor. CONCLUSIONS Spitz and Reed nevi express a higher immunoreactivity for estrogens than common nevi and melanomas, especially those with a high Breslow thickness; and immunoreactivity is higher in younger age groups.
{"title":"Expression of estrogen receptors in spitz and reed nevi.","authors":"V. Panasiti, M. Barone, R. Coppola, V. Devirgiliis, V. Roberti, P. Persichetti, S. Carotti, S. Morini","doi":"10.23736/S0392-0488.19.06376-4","DOIUrl":"https://doi.org/10.23736/S0392-0488.19.06376-4","url":null,"abstract":"BACKGROUND\u0000Estrogens play a key role in the skin: they are associated with an increased production of melanin, proliferation of melanocytes, increased skin thickness and increased cutaneous vascularization. Spitz and Reed nevi are acquired melanocytic lesions that generally develop during childhood or adolescence, a period of changes in sex hormones background. Our study project aimed at investigating, through immunohistochemical analysis, the expression levels of ERß receptors and their expression patterns (cytoplasmic or nuclear) in Spitz and Reed nevi.\u0000\u0000\u0000METHODS\u0000In our study we collected a total of 86 melanocytic lesions of patients: of these, 16 were common nevi, 23 were Spitz nevi, 18 were Reed nevi and 29 were melanomas. Expression curves for estrogen receptors were constructed using the Kaplan-Meier method and compared using a log-rank test.Statistical analysis was performed using MedCalc®. Immunohistochemical analysis on all histological sections of nevi and melanomas was performed to evaluate the expression levels of of ERß and their expression patterns (cytoplasmic or nuclear). The agreement between the operators was calculated using Fleiss κ values.\u0000\u0000\u0000RESULTS\u0000Correlation between immunoreactivity for the β-estrogen receptor and the sex of patients with Spitz and Reed nevi: immunoreactivity was higher in male patients. Correlation between β-estrogen receptor immunoreactivity and patient age for Spitz and Reed nevi: No statistically significant correlation was observed. Correlation between immunoreactivity for the β-estrogen receptor and histotype: Spitz and Reed nevi showed a high intensity, while in common nevi and in melanomas the immunoreactive was low. Correlation between receptor immunoreactivity for β estrogens and Breslow thickness in melanomas: Breslow thickness of non-immunoreactive melanomas for ERβ was much higher than those showing high immunoreactivity for this reeptor.\u0000\u0000\u0000CONCLUSIONS\u0000Spitz and Reed nevi express a higher immunoreactivity for estrogens than common nevi and melanomas, especially those with a high Breslow thickness; and immunoreactivity is higher in younger age groups.","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74819645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-01DOI: 10.23736/S0392-0488.19.06444-7
Jing Yu, Lian Zhang, Shuang Zhang, Guangyan Xian, Yuping Zhao, X. Bu
{"title":"MiR-29b inhibits hypertrophic scar tissue inflammation after burn through regulating TGF-β1/smad signaling pathway.","authors":"Jing Yu, Lian Zhang, Shuang Zhang, Guangyan Xian, Yuping Zhao, X. Bu","doi":"10.23736/S0392-0488.19.06444-7","DOIUrl":"https://doi.org/10.23736/S0392-0488.19.06444-7","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87176046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-01DOI: 10.23736/S0392-0488.18.06196-5
G. Nazzaro, E. Passoni, S. Muratori, C. Moltrasio, E. Guanziroli, M. Barbareschi, S. Veraldi, A. Marzano
BACKGROUND Hidradenitis suppurativa (HS) is a chronic, inflammatory disease that presents with nodules, abscesses and fistulae affecting the apocrine gland-bearing skin. Since few years, ultrasonography is used to better characterize HS skin lesions but comparison between clinical and sonographic scores has been made only in small series of patients. The aim is to assess concordance between clinical and sonographic scores in a larger cohort of HS patients. METHODS We conducted a retrospective observational study on 140 HS patients comparing two clinical score systems, Hurley and HS-Physical Global Assessment (PGA), with two ultrasonographic scores, SOnographic Score of Hidradenitis Suppurativa (SOS-HS) and ultrasonographic HS-PGA, a novel ultrasound scoring system set up by our group. We used the weighted Cohen's Kappa statistic (k) to evaluate the agreement. RESULTS Agreement between Hurley staging and SOS-HS was found in 61.4% of patients (weighted kappa 0.477), while agreement between clinical and ultrasonography HS-PGA scores was found in 35% of patients (weighted kappa 0.278), both findings suggesting a substantial disagreement. CONCLUSIONS Our study demonstrated a relevant disagreement between clinical and ultrasonography scores. Ultrasonography discovered non-clinically evident HS lesions, notably fistulae. Taken together, the above findings may support the view, previously suggested in expert panel reports, on the higher sensitivity of ultrasonography compared to clinics in HS.
化脓性湿疣炎(HS)是一种慢性炎症性疾病，表现为影响大汗腺皮肤的结节、脓肿和瘘管。近年来，超声检查被用于更好地表征HS皮肤病变，但仅在少数患者中进行了临床和超声评分的比较。目的是评估临床和超声评分之间的一致性在一个更大的队列HS患者。方法对140例HS患者进行回顾性观察研究，比较两种临床评分系统Hurley和HS- physical Global Assessment (PGA)，以及两种超声评分系统化脓性湿疣超声评分(SOS-HS)和超声评分系统HS-PGA。我们使用加权科恩Kappa统计量(k)来评估一致性。结果61.4%的患者Hurley分期与SOS-HS评分一致(加权kappa为0.477)，35%的患者临床与超声HS-PGA评分一致(加权kappa为0.278)，两者结果均提示存在实质性差异。结论本研究显示临床评分与超声评分存在相关差异。超声检查发现非临床明显的HS病变，尤其是瘘管。综上所述，上述发现可能支持先前专家小组报告中提出的观点，即超声检查与HS临床相比具有更高的灵敏度。
{"title":"Comparison of clinical and sonographic scores in hidradenitis suppurativa and proposal of a novel ultrasound scoring system.","authors":"G. Nazzaro, E. Passoni, S. Muratori, C. Moltrasio, E. Guanziroli, M. Barbareschi, S. Veraldi, A. Marzano","doi":"10.23736/S0392-0488.18.06196-5","DOIUrl":"https://doi.org/10.23736/S0392-0488.18.06196-5","url":null,"abstract":"BACKGROUND\u0000Hidradenitis suppurativa (HS) is a chronic, inflammatory disease that presents with nodules, abscesses and fistulae affecting the apocrine gland-bearing skin. Since few years, ultrasonography is used to better characterize HS skin lesions but comparison between clinical and sonographic scores has been made only in small series of patients. The aim is to assess concordance between clinical and sonographic scores in a larger cohort of HS patients.\u0000\u0000\u0000METHODS\u0000We conducted a retrospective observational study on 140 HS patients comparing two clinical score systems, Hurley and HS-Physical Global Assessment (PGA), with two ultrasonographic scores, SOnographic Score of Hidradenitis Suppurativa (SOS-HS) and ultrasonographic HS-PGA, a novel ultrasound scoring system set up by our group. We used the weighted Cohen's Kappa statistic (k) to evaluate the agreement.\u0000\u0000\u0000RESULTS\u0000Agreement between Hurley staging and SOS-HS was found in 61.4% of patients (weighted kappa 0.477), while agreement between clinical and ultrasonography HS-PGA scores was found in 35% of patients (weighted kappa 0.278), both findings suggesting a substantial disagreement.\u0000\u0000\u0000CONCLUSIONS\u0000Our study demonstrated a relevant disagreement between clinical and ultrasonography scores. Ultrasonography discovered non-clinically evident HS lesions, notably fistulae. Taken together, the above findings may support the view, previously suggested in expert panel reports, on the higher sensitivity of ultrasonography compared to clinics in HS.","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89126707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-01DOI: 10.23736/S0392-0488.18.06175-8
A. Raimondo, S. Lembo, G. Caiazzo, R. Di Caprio, A. Balato
BACKGROUND Psoriasis is a chronic, immune-mediated, inflammatory skin disease where interleukin-17 plays an important role in the underlying pathogenesis. IL-17A is a key driver of pro- osteoclastogenic process, that is abnormal in psoriatic patients. Aim of this study was to investigate in vivo the capability of secukinumab to influence the osteoclastogenesis in psoriatic patients reporting also our experience regarding the effectiveness and safety profile of this biological treatment. METHODS Efficacy and tolerability of secukinumab were evaluated after the induction period and 12 weeks. Moreover, to investigate how the cutaneous clinical improvement impacted also on the osteoclastogenic profile of psoriatic patients, the osteoclastogenic assay was performed in 5 secukinumab-treated psoriatic patients, not including psoriatic arthritis, before and after 5 weeks of therapy. RESULTS In line with clinical trials, our results confirmed the efficacy, speed of achievement and safety of secukinumab for the treatment of psoriatic patients. CONCLUSIONS Moreover, in our experiments, secukinumab has demonstrated speed of action also on osteoclastogenic process, reducing the number and activity of osteoclasts only after five weeks of treatment.
{"title":"Anti IL-17 therapy rapidly decreases osteoclast activity in psoriatic patients: a novel quality in addition to its efficacy and safety.","authors":"A. Raimondo, S. Lembo, G. Caiazzo, R. Di Caprio, A. Balato","doi":"10.23736/S0392-0488.18.06175-8","DOIUrl":"https://doi.org/10.23736/S0392-0488.18.06175-8","url":null,"abstract":"BACKGROUND\u0000Psoriasis is a chronic, immune-mediated, inflammatory skin disease where interleukin-17 plays an important role in the underlying pathogenesis. IL-17A is a key driver of pro- osteoclastogenic process, that is abnormal in psoriatic patients. Aim of this study was to investigate in vivo the capability of secukinumab to influence the osteoclastogenesis in psoriatic patients reporting also our experience regarding the effectiveness and safety profile of this biological treatment.\u0000\u0000\u0000METHODS\u0000Efficacy and tolerability of secukinumab were evaluated after the induction period and 12 weeks. Moreover, to investigate how the cutaneous clinical improvement impacted also on the osteoclastogenic profile of psoriatic patients, the osteoclastogenic assay was performed in 5 secukinumab-treated psoriatic patients, not including psoriatic arthritis, before and after 5 weeks of therapy.\u0000\u0000\u0000RESULTS\u0000In line with clinical trials, our results confirmed the efficacy, speed of achievement and safety of secukinumab for the treatment of psoriatic patients.\u0000\u0000\u0000CONCLUSIONS\u0000Moreover, in our experiments, secukinumab has demonstrated speed of action also on osteoclastogenic process, reducing the number and activity of osteoclasts only after five weeks of treatment.","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90649550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01DOI: 10.23736/S0392-0488.18.06133-3
M. Bergallo, V. Daprá, R. Ponti, P. Quaglino, M. Novelli, P. Fava, P. Montanari, Cristina Calvi, I. Galliano, M. Fierro
BACKGROUND Psoriasis is a common inflammatory skin disease characterized by uncontrolled proliferation of keratinocytes and recruitment of T lymphocytes into the skin. Possible triggers for psoriasis have been attributed to drugs or pathogens such as bacteria and possibly virus. Human endogenous retroviruses (HERVs) might play a role in triggering these anti-viral immune responses, since the role of HERVs in the pathogenesis of autoimmune diseases has generated considerable interest. Some studies have also reported an association of HERV-E and psoriasis. None of them investigate the HERV-E expression in peripheral blood of psoriasis. All these considerations have prompted us to perform a survey for HERV-E expression in PBMC from psoriatic patients. METHODS Peripheral blood mononuclear cells from 69 psoriatic patients were analyzed. Total RNA was extracted and amplified with reverse transcription polymerase chain reaction. Results were compared with those obtained in a cohort of 20 healthy donors. RESULTS HERV E was expressed in all samples analyzed but the level of expression was much lower in the psoriasis that in HC p<0.0001. CONCLUSIONS The reasons for the unexpected, low levels of HERV expression in psoriatic patients are unclear and might be in part a consequence of anti-viral defense mechanisms.
{"title":"HERV-E expression in peripheral mononuclear cells of patient with Psoriasis.","authors":"M. Bergallo, V. Daprá, R. Ponti, P. Quaglino, M. Novelli, P. Fava, P. Montanari, Cristina Calvi, I. Galliano, M. Fierro","doi":"10.23736/S0392-0488.18.06133-3","DOIUrl":"https://doi.org/10.23736/S0392-0488.18.06133-3","url":null,"abstract":"BACKGROUND\u0000Psoriasis is a common inflammatory skin disease characterized by uncontrolled proliferation of keratinocytes and recruitment of T lymphocytes into the skin. Possible triggers for psoriasis have been attributed to drugs or pathogens such as bacteria and possibly virus. Human endogenous retroviruses (HERVs) might play a role in triggering these anti-viral immune responses, since the role of HERVs in the pathogenesis of autoimmune diseases has generated considerable interest. Some studies have also reported an association of HERV-E and psoriasis. None of them investigate the HERV-E expression in peripheral blood of psoriasis. All these considerations have prompted us to perform a survey for HERV-E expression in PBMC from psoriatic patients.\u0000\u0000\u0000METHODS\u0000Peripheral blood mononuclear cells from 69 psoriatic patients were analyzed. Total RNA was extracted and amplified with reverse transcription polymerase chain reaction. Results were compared with those obtained in a cohort of 20 healthy donors.\u0000\u0000\u0000RESULTS\u0000HERV E was expressed in all samples analyzed but the level of expression was much lower in the psoriasis that in HC p<0.0001.\u0000\u0000\u0000CONCLUSIONS\u0000The reasons for the unexpected, low levels of HERV expression in psoriatic patients are unclear and might be in part a consequence of anti-viral defense mechanisms.","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76481284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01DOI: 10.23736/S0392-0488.18.06155-2
F. Pappalardo, E. Cozzani, A. Gallino, C. Mainetti
{"title":"Chronic refractory leg ulcers in mosaic Klinefelter's syndrome: the importance of a prompt diagnosis and appropriate treatment.","authors":"F. Pappalardo, E. Cozzani, A. Gallino, C. Mainetti","doi":"10.23736/S0392-0488.18.06155-2","DOIUrl":"https://doi.org/10.23736/S0392-0488.18.06155-2","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73787024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01DOI: 10.23736/S0392-0488.18.06191-6
N. Brandi, A. Alessandrini, M. Starace, B. Piraccini
{"title":"Keep your eyes wide open: how lifting the eyebrows can help exclude diagnosis of frontal fibrosing alopecia.","authors":"N. Brandi, A. Alessandrini, M. Starace, B. Piraccini","doi":"10.23736/S0392-0488.18.06191-6","DOIUrl":"https://doi.org/10.23736/S0392-0488.18.06191-6","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77021579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01DOI: 10.23736/S0392-0488.19.06163-7
C. Sung, Franchesca Choi, Spencer H. Wang, N. Jacobs, Gerald Maguire
{"title":"Non-antipsychotic therapies for delusions of parasitosis.","authors":"C. Sung, Franchesca Choi, Spencer H. Wang, N. Jacobs, Gerald Maguire","doi":"10.23736/S0392-0488.19.06163-7","DOIUrl":"https://doi.org/10.23736/S0392-0488.19.06163-7","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85014504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01DOI: 10.23736/S0392-0488.18.06205-3
I. Neri, A. Barisani, C. Baraldi, P. Fanti, A. Patrizi
{"title":"Lipedematous alopecia of the scalp in a Caucasian man: an atypical presentation.","authors":"I. Neri, A. Barisani, C. Baraldi, P. Fanti, A. Patrizi","doi":"10.23736/S0392-0488.18.06205-3","DOIUrl":"https://doi.org/10.23736/S0392-0488.18.06205-3","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85593585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01DOI: 10.23736/S0392-0488.18.06169-2
G. Tonini, Laura Casini, E. Cinotti, P. Rubegni
{"title":"Dermoscopic findings in Ashy dermatosis.","authors":"G. Tonini, Laura Casini, E. Cinotti, P. Rubegni","doi":"10.23736/S0392-0488.18.06169-2","DOIUrl":"https://doi.org/10.23736/S0392-0488.18.06169-2","url":null,"abstract":"","PeriodicalId":49071,"journal":{"name":"Giornale Italiano Di Dermatologia E Venereologia","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88949597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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